Invitrogen

CD8a Monoclonal Antibody (53-6.7), FITC, eBioscience™

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CD8a Antibody (11-0081-82) in Flow

Staining of C57BL/6 splenocytes with 0.25 µg of Rat IgG2a kappa Isotype Control FITC (Product # 11-4321-42) (open histogram) or 0.25 µg of Anti-Mouse CD8a FITC (filled histogram). Total viable cells were used for analysis.

CD8a Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

CD8a Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

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Product Details

11-0081-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 14 publications 14 publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Flow Cytometry (Flow)

0.5 µg/test

View 300 publications 300 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Functional Assay (Functional)

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fruit fly, Hamster, Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

53-6.7

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_464915

Product Specific Information

Description: The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.

Applications Reported: The 53-6.7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The 53-6.7 antibody has been tested by flow cytometric analysis of mouse thymocyte or splenocyte suspensions. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis.

STAR protocols

Wang R,Wang M,Pei S,Zhang Y,Guo S,Guo W,Wu Z,Wang H,Li Y,Zhu Y,Meng LH,Lang J,Jin G,Xiao Y,Hu L,Kong X

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Dec 15 00:00:00 EST 2023

ZDHHC9 promotes colon tumor growth by inhibiting effector T cells.

Oncology letters

Chong X,Zhu L,Yu D,Chen S,Wang G,Yu Q,Ma X,Xu J,Chen H,An H

11-0081-82 was used in flow cytometry to show that ZDHHC9 promotes colon cancer growth by upregulating the expression of PD-L1 and inhibiting the function of CD8+ T cells.

Sun Jan 01 00:00:00 EST 2023

Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells.

Nature communications

Iwanami N,Richter AS,Sikora K,Boehm T

11-0081-82 was used in Flow cytometry/Cell sorting to identify a role for Tnpo3 in regulating the splicing of the pre-mRNA encoding the cognate TCRα chain of iNKT cells.

Tue Jun 20 00:00:00 EDT 2023

Dendritic cell Piezo1 directs the differentiation of T_H1 and T_reg cells in cancer.

eLife

Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G

11-0081-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.

Mon Aug 22 00:00:00 EDT 2022

Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.

Nature cancer

Shen M,Smith HA,Wei Y,Jiang YZ,Zhao S,Wang N,Rowicki M,Tang Y,Hang X,Wu S,Wan L,Shao ZM,Kang Y

11-0081-82 was used in Flow Cytometry to reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer.

Sat Jan 01 00:00:00 EST 2022

Therapeutic potential of highly functional codon-optimized microutrophin for muscle-specific expression.

Scientific reports

Starikova AV,Skopenkova VV,Polikarpova AV,Reshetov DA,Vassilieva SG,Velyaev OA,Shmidt AA,Savchenko IM,Soldatov VO,Egorova TV,Bardina MV

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunohistochemistry

Mon Jan 17 00:00:00 EST 2022

Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis.

Cell reports. Medicine

Uceda-Castro R,Margarido AS,Cornet L,Vegna S,Hahn K,Song JY,Putavet DA,van Geldorp M,Çitirikkaya CH,de Keizer PLJ,Ter Beek LC,Borst GR,Akkari L,van Tellingen O,Broekman MLD,Vennin C,van Rheenen J

11-0081-82 was used in Immunohistochemistry (PFA fixed) to introduce immune-based treatments in this lethal disease.

Tue Nov 15 00:00:00 EST 2022

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.

The Journal of experimental medicine

Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment.

Current protocols

Taranto D,Ramirez CFA,Vegna S,de Groot MHP,de Wit N,Van Baalen M,Klarenbeek S,Akkari L

11-0081-82 was used in Flow cytometry/Cell sorting to describe several optimized protocols to generate, collect, and experimentally utilize various samples obtained from HCC somatic mouse models generated by HDTVi.

Tue Jun 01 00:00:00 EDT 2021

A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.

Frontiers in immunology

Di Giorgio E,Wang L,Xiong Y,Christensen LM,Akimova T,Han R,Samanta A,Trevisanut M,Brancolini C,Beier UH,Hancock WW

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Encapsulation of murine hematopoietic stem and progenitor cells in a thiol-crosslinked maleimide-functionalized gelatin hydrogel.

Acta biomaterialia

Gilchrist AE,Serrano JF,Ngo MT,Hrnjak Z,Kim S,Harley BAC

11-0081-82 was used in flow cytometry to report inclusion of a peptide crosslinker that can be cleaved via the proteolytic action of Sortase A and show that Sortase A exposure does not degrade sensitive surface marker expression patterns.

Wed Sep 01 00:00:00 EDT 2021

E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.

Nature communications

Gao P,Ma X,Yuan M,Yi Y,Liu G,Wen M,Jiang W,Ji R,Zhu L,Tang Z,Yu Q,Xu J,Yang R,Xia S,Yang M,Pan J,Yuan H,An H

11-0081 was used in Flow cytometry/Cell sorting to show that E3 ligase Nedd4l positively regulates antiviral immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.

Fri Feb 19 00:00:00 EST 2021

Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.

Vaccines

Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon May 10 00:00:00 EDT 2021

PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.

Frontiers in immunology

Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L

11-0081-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.

Mon Feb 28 00:00:00 EST 2022

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction.

eLife

Ramos MIP,Tian L,de Ruiter EJ,Song C,Paucarmayta A,Singh A,Elshof E,Vijver SV,Shaik J,Bosiacki J,Cusumano Z,Jensen C,Willumsen N,Karsdal MA,Liu L,Langermann S,Willems S,Flies D,Meyaard L

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Jun 14 00:00:00 EDT 2021

Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior.

Advanced functional materials

Ngo MT,Barnhouse VR,Gilchrist AE,Mahadik BP,Hunter CJ,Hensold JN,Petrikas N,Harley BAC

11-0081-82 was used in Flow cytometry/Cell sorting to report the successful development of a microfluidic device to generate hydrogels containing lateral gradients in vascular density as a means to identify angiocrine signals underlying hematopoietic stem cell culture ex vivo.

Thu Dec 16 00:00:00 EST 2021

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

11-0081-82 was used in Flow cytometry/Cell sorting to demonstrated that CD8+ T-lymphocytes play a key role in supporting the survival of reparative MoMFs during liver healing trough ICOS/ICOSL-mediated signaling.

Mon Feb 14 00:00:00 EST 2022

Myocardial infarction accelerates breast cancer via innate immune reprogramming.

Nature medicine

Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,Jones LW,Moore KJ

11-0081 was used in Flow cytometry/Cell sorting to show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. I.

Tue Sep 01 00:00:00 EDT 2020

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics.

Immunity

Zenke S,Palm MM,Braun J,Gavrilov A,Meiser P,Böttcher JP,Beyersdorf N,Ehl S,Gerard A,Lämmermann T,Schumacher TN,Beltman JB,Rohr JC

11-0081 was used in Flow cytometry/Cell sorting to conclude that CD8+ T cell-population-intrinsic mechanisms regulate cellular behavior, thereby promoting robustness of population dynamics.

Tue Feb 18 00:00:00 EST 2020

Respiratory syncytial virus infection exacerbates pneumococcal pneumonia via Gas6/Axl-mediated macrophage polarization.

The Journal of clinical investigation

Shibata T,Makino A,Ogata R,Nakamura S,Ito T,Nagata K,Terauchi Y,Oishi T,Fujieda M,Takahashi Y,Ato M

11-0081 was used in Flow cytometry/Cell sorting to identify potentially novel cellular and molecular cascades triggered by RSV infection to exacerbate secondary pneumococcal pneumonia.

Mon Jun 01 00:00:00 EDT 2020

Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells.

Brain, behavior, and immunity

Piras G,Rattazzi L,Paschalidis N,Oggero S,Berti G,Ono M,Bellia F,D'Addario C,Dell'Osso B,Pariante CM,Perretti M,D'Acquisto F

11-0081-82 was used in Flow Cytometry to identify a novel factor, a small protein of approximately 21 kDa encoded by the gene 2610019F03Rik, thus named Immuno-moodulin, associated with overexpressing Annexin-A1 exclusively in T cells, as a novel peripheral determinant that modulates anxiety behavior.

Wed Jul 01 00:00:00 EDT 2020

Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies.

ACS nano

Ou YC,Wen X,Johnson CA,Shae D,Ayala OD,Webb JA,Lin EC,DeLapp RC,Boyd KL,Richmond A,Mahadevan-Jansen A,Rafat M,Wilson JT,Balko JM,Tantawy MN,Vilgelm AE,Bardhan R

11-0081 was used in Flow cytometry/Cell sorting to show a multifunctional nanoscale probe with capabilities that cannot be achieved with either modality alone, allowing multiplexed immunologic tumor profiling critical for predicting early response to immunotherapies.

Tue Jan 28 00:00:00 EST 2020

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.

The Journal of experimental medicine

Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.

EMBO molecular medicine

Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Oct 07 00:00:00 EDT 2020

Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.

EMBO molecular medicine

Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L

11-0081 was used in Flow cytometry/Cell sorting to determine steps within PD-1 signalling pathway that can be targeted in anticancer drugs.

Mon Jun 08 00:00:00 EDT 2020

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.

PLoS biology

Kobia FM,Preusse K,Dai Q,Weaver N,Hass MR,Chaturvedi P,Stein SJ,Pear WS,Yuan Z,Kovall RA,Kuang Y,Eafergen N,Sprinzak D,Gebelein B,Brunskill EW,Kopan R

11-0081 was used in Flow cytometry/Cell sorting to highlight the role of the environment in malignancy and colitis and is consistent with Notch-dependent anti-parasite immune responses being compromised in Notch dimer-deficient animals.

Thu Oct 01 00:00:00 EDT 2020

The membrane protein Raw regulates dendrite pruning via the secretory pathway.

Development (Cambridge, England)

Rui M,Bu S,Chew LY,Wang Q,Yu F

11-0081-82 was used in Immunohistochemistry to reveal a JNK-independent role of Raw in regulating the secretory pathway and thereby promoting dendrite pruning.

Fri Oct 09 00:00:00 EDT 2020

Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus.

Journal of cell science

Salz A,Gurniak C,Jönsson F,Witke W

11-0081 was used in Flow cytometry/Cell sorting to describe a novel role of cofilin1 in the physiological context of migration-dependent cell differentiation.

Fri Mar 06 00:00:00 EST 2020

Mice carrying an analogous heterozygous dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy.

Human molecular genetics

Pereira JA,Gerber J,Ghidinelli M,Gerber D,Tortola L,Ommer A,Bachofner S,Santarella F,Tinelli E,Lin S,Rüegg MA,Kopf M,Toyka KV,Suter U

11-0081 was used in Flow cytometry/Cell sorting to describe the analysis of mice carrying the DNM2 K562E mutation which has been associated with dominant-intermediate CMT type B.

Thu May 28 00:00:00 EDT 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.

Molecular and cellular endocrinology

Porsche CE,Delproposto JB,Patrick E,Zamarron BF,Lumeng CN

11-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of dendritic cells to adipose tissue derived chronic inflammation as professional antigen presenting cells in adipose issue.

Sun Apr 05 00:00:00 EDT 2020

Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.

Integrative biology : quantitative biosciences from nano to macro

Gilchrist AE,Harley BAC

11-0081-82 was used in Flow Cytometry to investigate the mechanism of how marrow-derived mesenchymal stromal and progenitor cells impacts hematopoietic stem cells fate decisions.

Fri Jul 10 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.

Frontiers in immunology

Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Mar 26 00:00:00 EDT 2021

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Loss of testosterone impairs anti-tumor neutrophil function.

Nature communications

Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Mar 31 00:00:00 EDT 2020

TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis.

Cancers

Chan YL,Lai WC,Chen JS,Tseng JT,Chuang PC,Jou J,Lee CT,Sun HS

11-0081 was used in Flow cytometry/Cell sorting to suggest that TIAM2S provokes a pro-inflammatory immune microenvironment permissive to colorectal tumorigenesis through the serotonin-induced immunomodulatory effects.

Wed Jul 08 00:00:00 EDT 2020

TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis.

Cancers

Chan YL,Lai WC,Chen JS,Tseng JT,Chuang PC,Jou J,Lee CT,Sun HS

Wed Jul 08 00:00:00 EDT 2020

Mesenchymal stem cells protect against malaria pathogenesis by reprogramming erythropoiesis in the bone marrow.

Cell death discovery

Thakur RS,Awasthi V,Sanyal A,Chatterjee S,Rani S,Chauhan R,Kalkal M,Tiwari M,Pande V,Das J

11-0081 was used in Flow cytometry/Cell sorting to suggest that MSCs play a critical role in host protection against malaria infection by modulating erythropoiesis and lymphopoiesis.

Sun Nov 15 00:00:00 EST 2020

Control of Viral Infection by Natural Killer Cell Inhibitory Receptors.

Cell reports

Parikh BA,Bern MD,Piersma SJ,Yang L,Beckman DL,Poursine-Laurent J,Plougastel-Douglas B,Yokoyama WM

11-0081 was used in Flow cytometry/Cell sorting to show MHC-I-restricted control of murine cytomegalovirus (MCMV) infection in vivo that is NK cell dependent.

Tue Jul 28 00:00:00 EDT 2020

Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.

Journal for immunotherapy of cancer

Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.

Journal for immunotherapy of cancer

Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer.

Journal for immunotherapy of cancer

Bai F,Zhang P,Fu Y,Chen H,Zhang M,Huang Q,Li D,Li B,Wu K

11-0081-82 was used in Flow Cytometry to show that ANXA1 expression is associated with lower survival and a higher risk of breast malignancy.

Wed Apr 01 00:00:00 EDT 2020

Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.

Science advances

Ma C,Yang D,Wang B,Wu C,Wu Y,Li S,Liu X,Lassen K,Dai L,Yang S

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.

Cell reports

Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ

11-0081 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.

Tue Jan 07 00:00:00 EST 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

11-0081 was used in Flow cytometry/Cell sorting to study can serve as a foundation for trials testing immunotherapeutic approaches in patients with ovarian GCT.

Thu Aug 20 00:00:00 EDT 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

A Cu₉S₅ nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy.

Communications biology

Zhou L,Chen L,Hu X,Lu Y,Liu W,Sun Y,Yao T,Dong C,Shi S

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunohistochemistry

Fri Jul 03 00:00:00 EDT 2020

Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts.

Frontiers in immunology

Govender L,Mikulic J,Wyss JC,Gaide O,Thome M,Golshayan D

11-0081-82 was used in Flow Cytometry to compare targeting Malt1 versus using calcineurin inhibitors as immunosuppression in a stringent experimental transplantation model.

Fri Jun 18 00:00:00 EDT 2021

Specific targeting of IL-1β activity to CD8⁺ T cells allows for safe use as a vaccine adjuvant.

NPJ vaccines

Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Sep 19 00:00:00 EDT 2023

CD8⁺ T cells induce cachexia during chronic viral infection.

Nature immunology

Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A

11-0081-82 was used in Flow Cytometry to identify the role for CD8+ T cells in infection-associated cachexia.

Sat Jun 01 00:00:00 EDT 2019

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

11-0081 was used in Flow cytometry/Cell sorting to study the mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology.

Fri Mar 01 00:00:00 EST 2019

cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.

The Journal of clinical investigation

Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X

11-0081 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.

Tue Aug 13 00:00:00 EDT 2019

miR-146a Controls Immune Response in the Melanoma Microenvironment.

Cancer research

Mastroianni J,Stickel N,Andrlova H,Hanke K,Melchinger W,Duquesne S,Schmidt D,Falk M,Andrieux G,Pfeifer D,Dierbach H,Schmitt-Graeff A,Meiss F,Boerries M,Zeiser R

11-0081-82 was used in Flow Cytometry to identify miR-146a as a negative regulator of immune activation, comparable to immune-checkpoint molecules.

Tue Jan 01 00:00:00 EST 2019

Memory CD4⁺ T cells enhance B-cell responses to drifting influenza immunization.

European journal of immunology

Gage E,Van Hoeven N,Dubois Cauwelaert N,Larsen SE,Erasmus J,Orr MT,Coler RN

11-0081-82 was used in Flow Cytometry to show that MHC Class II haplotype and T-cell reactivity influences subsequent hemagglutination inhibitory antibody responses.

Fri Feb 01 00:00:00 EST 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

11-0081-82 was used in Flow Cytometry to performed immunophenotypic analysis of bone marrow cells and splenocytes from both genders of three commonly used murine strains (C57BL/6NCr, 129/SvHsd, and BALB/cAnNCr).

Tue Jan 01 00:00:00 EST 2019

Antiallodynic Effects of Cannabinoid Receptor 2 (CB₂R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.

Pain research & management

Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Dec 16 00:00:00 EST 2019

Hemozoin produced by mammals confers heme tolerance.

eLife

Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Western Blot

Tue Oct 01 00:00:00 EDT 2019

Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.

International journal of medical sciences

Kim HR,Rahman FU,Kim KS,Kim EK,Cho SM,Lee K,Moon OS,Seo YW,Yoon WK,Won YS,Kang H,Kim HC,Nam KH

11-0081-82 was used in Flow Cytometry to suggest that E2F3 has a pivotal role in muscle and bone development, and affect normal mouse growth.

Thu Apr 30 00:00:00 EDT 2020

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

11-0081-82 was used in Flow cytometry/Cell sorting to suggest that the ZIKV NS4B-C100S mutant may serve as a candidate ZIKV LAV due to its attenuated phenotype and high immunogenicity.

Thu Oct 01 00:00:00 EDT 2020

Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-β1 and PILR-α.

eLife

Li YT,Goswami D,Follmer M,Artz A,Pacheco-Blanco M,Vestweber D

11-0081-82 was used in Flow Cytometry to show that PILR-b1 on neutrophils and CD99 on endothelium represent a new pair of important players in the multistep cascade of leukocyte extravasation, which are needed to support the combined function of selectins, chemokines and integrins.

Tue Aug 06 00:00:00 EDT 2019

The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.

Frontiers in pharmacology

Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK

11-0081 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.

Wed Sep 30 00:00:00 EDT 2020

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.

Immunity

Wang M,Zhang S,Zheng G,Huang J,Songyang Z,Zhao X,Lin X

11-0081 was used in Flow cytometry/Cell sorting to show CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis.

Tue Jul 17 00:00:00 EDT 2018

CD150^high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.

Cell stem cell

Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J

11-0081-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.

Thu Mar 01 00:00:00 EST 2018

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.

The Journal of experimental medicine

Zhang W,Li Q,Li D,Li J,Aki D,Liu YC

11-0081 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.

Mon Dec 03 00:00:00 EST 2018

Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.

Frontiers in immunology

Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K

11-0081 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.

Tue Jun 25 00:00:00 EDT 2019

NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis.

Frontiers in immunology

Nico D,Martins Almeida F,Maria Motta J,Soares Dos Santos Cardoso F,Freire-de-Lima CG,Freire-de-Lima L,de Luca PM,Maria Blanco Martinez A,Morrot A,Palatnik-de-Sousa CB

11-0081 was used in Flow cytometry/Cell sorting to assess whether NH36 or the F3 peptide are capable of preventing the migrating effect of dendritic cells by restoring the expression of CCR7 receptors.

Thu Jul 11 00:00:00 EDT 2019

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.

Frontiers in immunology

Baur J,Otto C,Steger U,Klein-Hessling S,Muhammad K,Pusch T,Murti K,Wismer R,Germer CT,Klein I,Müller N,Serfling E,Avots A

Wed Nov 20 00:00:00 EST 2019

Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.

Frontiers in immunology

Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ

11-0081 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.

Sun Jan 03 00:00:00 EST 2021

Varying Immunizations With Plasmodium Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8⁺ T Cell Dynamics.

Frontiers in immunology

Frank R,Gabel M,Heiss K,Mueller AK,Graw F

Tue Jul 30 00:00:00 EDT 2019

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.

Frontiers in immunology

Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L

11-0081-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.

Wed Apr 10 00:00:00 EDT 2019

STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.

Molecular oncology

Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity.

International journal of oncology

Yoshida M,Taguchi A,Kawana K,Ogishima J,Adachi K,Kawata A,Nakamura H,Sato M,Fujimoto A,Inoue T,Tomio K,Mori M,Nagamatsu T,Arimoto T,Koga K,Hiraike OW,Oda K,Kiyono T,Osuga Y,Fujii T

Mon Oct 01 00:00:00 EDT 2018

Betaine Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Dendritic Cell-Derived IL-6 Production and Th17 Differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Yang C,Lai W,Zhou J,Zheng X,Cai Y,Yang W,Xie S,Gao Y,Du C

11-0081 was used in Flow cytometry/Cell sorting to demonstrate the pivotal roles of betaine in modulating MS pathogenesis and suggested that it may serve as a potential novel drug candidate for the treatment of MS.

Thu Feb 15 00:00:00 EST 2018

Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.

Oncology reports

Lei H,Wang G,Zhang J,Han Q

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Anti-CD200 attenuates concanavalin A induced hepatitis via modulating the imbalance of CD4⁺ T lymphocyte differentiation in mice.

American journal of translational research

Zhao X,Ding S,Geng C,Man Z,Pan M,Sun L,Hu B,Wang H

11-0081 was used in Flow cytometry/Cell sorting to research the effect of CD200 on the differentiation of CD4+ T lymphocyte.

Wed Sep 30 00:00:00 EDT 2020

Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.

Infection and immunity

Denham ST,Verma S,Reynolds RC,Worne CL,Daugherty JM,Lane TE,Brown JCS

11-0081-82 was used in Flow cytometry/Cell sorting to show that exo-glucuronoxylomannan (exo-GXM) performs a different role from capsule GXM during infection, altering cell size and suppressing inflammation.

Thu Mar 01 00:00:00 EST 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.

eLife

Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Sep 06 00:00:00 EDT 2018

A protocol for generating induced T cells by reprogramming B cells in vivo.

Cell regeneration (London, England)

Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.

Cell reports

Ravussin A,Youm YH,Sander J,Ryu S,Nguyen K,Varela L,Shulman GI,Sidorov S,Horvath TL,Schultze JL,Dixit VD

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Jul 31 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

11-0081 was used in Flow cytometry/Cell sorting to assess the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase 1 axis as a druggable mitochondrial target for promoting immunometabolic and organ homeostasis during sepsis.

Thu Aug 09 00:00:00 EDT 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Wed Mar 28 00:00:00 EDT 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Wed Mar 28 00:00:00 EDT 2018

Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.

Scientific reports

Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunohistochemistry

Tue Feb 13 00:00:00 EST 2018

Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.

Scientific reports

Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunohistochemistry

Tue Feb 13 00:00:00 EST 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

11-0081 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.

Wed Apr 18 00:00:00 EDT 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

11-0081 was used in Flow cytometry/Cell sorting to study the role of microglia in preventing immune infiltration and promoting an anti-inflammatory environment in the brain.

Fri Sep 21 00:00:00 EDT 2018

Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.

Cell death & disease

Lai D,Tang J,Chen L,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Fang X,Shu Q,Fan J

Tue Mar 06 00:00:00 EST 2018

In utero nanoparticle delivery for site-specific genome editing.

Nature communications

Ricciardi AS,Bahal R,Farrelly JS,Quijano E,Bianchi AH,Luks VL,Putman R,López-Giráldez F,Coşkun S,Song E,Liu Y,Hsieh WC,Ly DH,Stitelman DH,Glazer PM,Saltzman WM

11-0081 was used in Flow cytometry/Cell sorting to demonstrate the safe intravenous and intra-amniotic administration of polymeric nanoparticles to foetal mouse tissues at selected gestational ages with no effect on survival or postnatal growth.

Tue Jun 26 00:00:00 EDT 2018

Limited Foxp3⁺ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8⁺ T Cell Immunity.

Frontiers in immunology

Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV

11-0081 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.

Thu Sep 26 00:00:00 EDT 2019

Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.

Cell

Isoda T,Moore AJ,He Z,Chandra V,Aida M,Denholtz M,Piet van Hamburg J,Fisch KM,Chang AN,Fahl SP,Wiest DL,Murre C

11-0081 was used in Flow cytometry/Cell sorting to study the repositioning of the Bcl11b enhancer to dictate the fate of developing T cells.

Thu Sep 21 00:00:00 EDT 2017

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Immunity

Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM

11-0081 was used in Flow cytometry to demonstrate that glucokinase-dependent glycolysis regulates regulatory T cell migration.

Tue Nov 21 00:00:00 EST 2017

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

11-0081 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.

Mon Dec 11 00:00:00 EST 2017

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

The Journal of clinical investigation

Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.

Science translational medicine

Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

The Journal of experimental medicine

Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG

11-0081 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.

Mon Apr 03 00:00:00 EDT 2017

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.

Developmental cell

Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH

Mon Aug 07 00:00:00 EDT 2017

Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.

Cancer research

Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B

11-0081-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.

Wed Nov 01 00:00:00 EDT 2017

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b⁺Ly6G⁺ intratumor myeloid cells through the TICAM-1 signaling pathway.

Cell death and differentiation

Shime H,Matsumoto M,Seya T

11-0081 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.

Wed Mar 01 00:00:00 EST 2017

A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2⁺ T Cells.

Frontiers in immunology

Yu Q,Wang X,Fan X

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8⁺ T Cells.

Frontiers in immunology

Wang W,Shahzad KA,Li M,Zhang A,Zhang L,Xu T,Wan X,Shen C

Wed Nov 20 00:00:00 EST 2019

Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.

Mucosal immunology

Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL

11-0081 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.

Mon May 01 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.

Journal of virology

Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK

11-0081 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.

Mon May 15 00:00:00 EDT 2017

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8⁺ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.

Chinese medical journal

Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sat May 20 00:00:00 EDT 2017

Immunological phenotype of the murine Lrba knockout.

Immunology and cell biology

Gámez-Díaz L,Neumann J,Jäger F,Proietti M,Felber F,Soulas-Sprauel P,Perruzza L,Grassi F,Kögl T,Aichele P,Kilimann M,Grimbacher B,Jung S

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

11-0081 was used in Flow cytometry/Cell sorting to suggest that newly created lymphatic vessels in the cornea driven by HSV-1 infection are critical in the delivery of soluble viral antigen to the draining lymph node.

Sun Jan 01 00:00:00 EST 2017

The inflammatory phase of fracture healing is influenced by oestrogen status in mice.

European journal of medical research

Haffner-Luntzer M,Fischer V,Prystaz K,Liedert A,Ignatius A

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Thu Jul 06 00:00:00 EDT 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.

Frontiers in neurology

Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J

11-0081 was used in Flow cytometry/Cell sorting to suggest that IL-2C treatment can alleviate inflammation and maintain blood vessel stability after traumatic brain injury.

Thu Oct 01 00:00:00 EDT 2020

Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice.

Molecular medicine reports

Tang A,Li C,Chen Z,Li T

11-0081 was used in Flow cytometry/Cell sorting to suggest that anti-CD20 and IL-10 treatment in NOD mice can modulate the immune functions by up-regulating GATA-3 and IL-4 expression as well as down-regulating T-bet and IFN-γ expression.

Sun Oct 01 00:00:00 EDT 2017

Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.

Experimental and therapeutic medicine

Wang J,Gao ZP,Qin S,Liu CB,Zou LL

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Transient Treg depletion enhances therapeutic anti-cancer vaccination.

Immunity, inflammation and disease

Fisher SA,Aston WJ,Chee J,Khong A,Cleaver AL,Solin JN,Ma S,Lesterhuis WJ,Dick I,Holt RA,Creaney J,Boon L,Robinson B,Lake RA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.

Nature communications

Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon May 15 00:00:00 EDT 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Jan 06 00:00:00 EST 2017

Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.

Oncoimmunology

Schröder M,Loos S,Naumann SK,Bachran C,Krötschel M,Umansky V,Helming L,Swee LK

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

IL-12 Influence mTOR to Modulate CD8⁺ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.

International journal of medical sciences

Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon May 21 00:00:00 EDT 2018

Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.

Nature communications

Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2017

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Nov 16 00:00:00 EST 2017

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

Nature communications

Rossey I,Gilman MS,Kabeche SC,Sedeyn K,Wrapp D,Kanekiyo M,Chen M,Mas V,Spitaels J,Melero JA,Graham BS,Schepens B,McLellan JS,Saelens X

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Hepatic stroma-educated regulatory DCs suppress CD8⁺ T cell proliferation in mice.

Oncotarget

Wang Q,He H,Chen D,Wang C,Xu Y,Song W

11-0081 was used in Flow cytometry/Cell sorting to assess whether and how liver dendritic cells suppress CD8+ T cells.

Tue Nov 07 00:00:00 EST 2017

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.

Nature communications

Ratsimandresy RA,Chu LH,Khare S,de Almeida L,Gangopadhyay A,Indramohan M,Misharin AV,Greaves DR,Perlman H,Dorfleutner A,Stehlik C

11-0081 was used in Flow cytometry/Cell sorting to investigate the complex interactions governing inflammasome assembly and function.

Mon Jun 05 00:00:00 EDT 2017

LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4⁺ T cells.

Oncoimmunology

Liu H,Zhang Y,Liu Z,Wang P,Mo X,Fu W,Liu W,Cheng Y,Han W

11-0081 was used in Flow cytometry/Cell sorting to reveal a tumor-inhibiting role for LYG1 through promoting the activation, proliferation, and function of CD4+T cells in antitumor immune responses, offering implications for novel tumor immunotherapy.

Tue Jan 12 00:00:00 EST 2021

Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.

Oncotarget

Peer S,Baier G,Gruber T

11-0081 was used in Flow cytometry/Cell sorting to show that Cblb-/- T cells are less susceptible to PD-L1-mediated suppression of T cell proliferation and IFNγ secretion.

Tue Jun 27 00:00:00 EDT 2017

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Scientific reports

Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Mon Jan 09 00:00:00 EST 2017

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

11-0081 was used in Flow cytometry/Cell sorting to investigate the regulatory effects of rottlerin on normal human epidermal keratinocytes and imiquimod-induced psoriasiform lesions.

Tue Jan 16 00:00:00 EST 2018

NFATc1 controls the cytotoxicity of CD8⁺ T cells.

Nature communications

Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E

11-0081 was used in Flow cytometry/Cell sorting to indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.

Mon Sep 11 00:00:00 EDT 2017

Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas.

Medical science monitor : international medical journal of experimental and clinical research

Li J,Liu X,Duan Y,Liu Y,Wang H,Lian S,Zhuang G,Fan Y

11-0081 was used in Flow cytometry/Cell sorting to indicate that combined blockade of T cell immunoglobulin and mucin domain 3 and carcinoembryonic antigen-related cell adhesion molecule 1 generates robust therapeutic efficacy in mice with intracranial tumours.

Mon Jul 24 00:00:00 EDT 2017

Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter.

Respiratory research

Jaligama S,Saravia J,You D,Yadav N,Lee GI,Shrestha B,Cormier SA

11-0081 was used in Flow cytometry/Cell sorting to show that murine neonate exposure to environmentally persistent free radicals induces regulatory T Cells and IL10 resulting in suppressed adaptive T cell responses and increased severity of influenza.

Fri Jan 13 00:00:00 EST 2017

A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease.

Immunology and cell biology

Shibata T,Ato M

11-0081-82 was used in Flow cytometry/Cell sorting to indicate that RSV-G protein-induced Gas6/Axl signaling causes allergic airway responses during FI-RSV VED.

Wed Nov 01 00:00:00 EDT 2017

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.

Nature

Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Apr 21 00:00:00 EDT 2016

Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.

Nature

Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Apr 21 00:00:00 EDT 2016

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Cell

Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Aug 25 00:00:00 EDT 2016

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.

Immunity

Tian Y,Kuo CF,Akbari O,Ou JH

Tue May 17 00:00:00 EDT 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.

Nature cell biology

Welte T,Kim IS,Tian L,Gao X,Wang H,Li J,Holdman XB,Herschkowitz JI,Pond A,Xie G,Kurley S,Nguyen T,Liao L,Dobrolecki LE,Pang L,Mo Q,Edwards DP,Huang S,Xin L,Xu J,Li Y,Lewis MT,Wang T,Westbrook TF,Rosen JM,Zhang XH

11008182 was used in flow cytometry to describe the role of mTOR signalling in recruiting pro-tumorigenic myeloid-derived suppressor cells.

Wed Jun 01 00:00:00 EDT 2016

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.

The Journal of experimental medicine

Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.

Mon Nov 14 00:00:00 EST 2016

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.

Cancer research

Tavaré R,Escuin-Ordinas H,Mok S,McCracken MN,Zettlitz KA,Salazar FB,Witte ON,Ribas A,Wu AM

11-0081 was used in Flow cytometry/Cell sorting to investigate anti-CD8 immuno-PET as a sensitive tool for tracking systemic and tumour-infiltrating CD8+ T cell expression in tumour immunotherapy models.

Fri Jan 01 00:00:00 EST 2016

Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.

Frontiers in immunology

Akk A,Springer LE,Pham CT

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.

Frontiers in immunology

Schmitt ME,Sitte S,Voehringer D

11-0081 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.

Wed Nov 20 00:00:00 EST 2019

The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses.

Frontiers in immunology

Akhmatova NK,Kurbatova EA,Akhmatov EA,Egorova NB,Logunov DY,Gening ML,Sukhova EV,Yashunsky DV,Tsvetkov YE,Nifantiev NE

11-0081 was used in Flow cytometry/Cell sorting to evaluate the effects of immunisation with a synthetic hexasaccharide conjugate, with and without an adjuvant, on TLR activation, dendritic cell maturation, and cytokine production in mice.

Fri Jul 22 00:00:00 EDT 2016

Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Stem cells translational medicine

Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

11-0081 was used in Flow cytometry/Cell sorting to suggest persistent viral lytic gene expression during latency causes chronic inflammatory response inducing exhaustion of resident T cells in the ependyma.

Mon Aug 15 00:00:00 EDT 2016

Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Hilpert C,Sitte S,Matthies A,Voehringer D

11-0081 was used in Flow cytometry/Cell sorting to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.

Sat Oct 01 00:00:00 EDT 2016

Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo.

Oncology reports

Gabrysiak M,Wachowska M,Barankiewicz J,Pilch Z,Ratajska A,Skrzypek E,Winiarska M,Domagala A,Rygiel TP,Jozkowicz A,Boon L,Golab J,Firczuk M

11-0081 was used in Flow cytometry/Cell sorting to identify factors allowing for the most immunogenic response to photodynamic therapy.

Wed Jun 01 00:00:00 EDT 2016

Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation.

Molecular medicine reports

Ren J,Meng S,Yan B,Yu J,Liu J

11-0081 was used in Flow cytometry/Cell sorting to show that protectin D1 reduces concanavalin A-induced liver injury..

Fri Apr 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.

Scientific reports

Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Sep 13 00:00:00 EDT 2016

Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.

Scientific reports

Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Sep 13 00:00:00 EDT 2016

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Scientific reports

Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Jul 11 00:00:00 EDT 2016

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.

Nature communications

Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Oct 21 00:00:00 EDT 2016

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.

Nature communications

Du C,Duan Y,Wei W,Cai Y,Chai H,Lv J,Du X,Zhu J,Xie X

11-0081 was used in Flow cytometry/Cell sorting to show that kappa opioid receptor activation alleviates autoimmune encephalomyelitis and promotes remyelination..

Mon Apr 04 00:00:00 EDT 2016

A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo.

Oncotarget

Wang W,Fang K,Li MC,Chang D,Shahzad KA,Xu T,Zhang L,Gu N,Shen CL

11-0081 was used in Flow cytometry/Cell sorting to investigate whether poly(lactic-co-glycolic acid) polyesters can covalently load antigen and mAb to generate killer microparticles able to deplete antigen-specific T cells.

Tue Mar 15 00:00:00 EDT 2016

Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus.

Frontiers in cellular neuroscience

Klein B,Mrowetz H,Thalhamer J,Scheiblhofer S,Weiss R,Aigner L

11-0081 was used in Flow cytometry/Cell sorting to investigate the effects of allergic lung inflammation on the hippocampus in mice clinically sensitised with a grass pollen allergen.

Fri Jul 22 00:00:00 EDT 2016

p21^Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα.

Scientific reports

Lopez-Guadamillas E,Fernandez-Marcos PJ,Pantoja C,Muñoz-Martin M,Martínez D,Gómez-López G,Campos-Olivas R,Valverde AM,Serrano M

11-0081 was used in Flow cytometry/Cell sorting to examine the expression of several tumour suppressors upon fasting in mice.

Mon Oct 10 00:00:00 EDT 2016

Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation.

Scientific reports

Hu HT,Umemori H,Hsueh YP

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunoprecipitation

Thu Sep 15 00:00:00 EDT 2016

Enhanced Immune Response in Immunodeficient Mice Improves Peripheral Nerve Regeneration Following Axotomy.

Frontiers in cellular neuroscience

Bombeiro AL,Santini JC,Thomé R,Ferreira ER,Nunes SL,Moreira BM,Bonet IJ,Sartori CR,Verinaud L,Oliveira AL

11-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of lymphocytes during peripheral nerve regeneration in immunocompetent versus immunodeficient mice.

Wed Jul 06 00:00:00 EDT 2016

MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.

eLife

Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S

11-0081 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.

Tue Jan 26 00:00:00 EST 2016

Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.

PloS one

Jonas BA,Johnson C,Gratzinger D,Majeti R

11-0081 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.

Wed Jul 26 00:00:00 EDT 2017

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

11008182 was used in flow cytometry to assess whether flagellin is useful as an adjuvant for a topical therapeutic vaccine for female genital cancer

Mon Feb 01 00:00:00 EST 2016

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

11-0081 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.

PloS one

Qualai J,Li LX,Cantero J,Tarrats A,Fernández MA,Sumoy L,Rodolosse A,McSorley SJ,Genescà M

11-0081 was used in Flow cytometry/Cell sorting to find markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T cells.

Thu Mar 16 00:00:00 EDT 2017

MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury.

PloS one

Bombeiro AL,Thomé R,Oliveira Nunes SL,Monteiro Moreira B,Verinaud L,Oliveira AL

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Wed Jul 26 00:00:00 EDT 2017

MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury.

PloS one

Bombeiro AL,Thomé R,Oliveira Nunes SL,Monteiro Moreira B,Verinaud L,Oliveira AL

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Wed Jul 26 00:00:00 EDT 2017

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.

The Journal of clinical investigation

Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2015

An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.

The Journal of experimental medicine

Hao B,Naik AK,Watanabe A,Tanaka H,Chen L,Richards HW,Kondo M,Taniuchi I,Kohwi Y,Kohwi-Shigematsu T,Krangel MS

11-0081 was used in Flow cytometry/Cell sorting to provide a novel framework for understanding ASE function for gene expression in double-positive thymocytes.

Mon May 04 00:00:00 EDT 2015

Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.

The Journal of experimental medicine

Vijay R,Hua X,Meyerholz DK,Miki Y,Yamamoto K,Gelb M,Murakami M,Perlman S

11-0081 was used in Flow cytometry/Cell sorting to investigate the enhanced expression of proresolving/antiinflammatory factors in ageing, showing a critical role of phospholipase A2 group IID.

Mon Oct 19 00:00:00 EDT 2015

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science advances

Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH

11-0081 was used in Flow cytometry/Cell sorting to illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions.

Tue Sep 01 00:00:00 EDT 2015

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Cardiovascular research

Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2015

CD31 signals confer immune privilege to the vascular endothelium.

Proceedings of the National Academy of Sciences of the United States of America

Cheung K,Ma L,Wang G,Coe D,Ferro R,Falasca M,Buckley CD,Mauro C,Marelli-Berg FM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2015

CD31 signals confer immune privilege to the vascular endothelium.

Proceedings of the National Academy of Sciences of the United States of America

Cheung K,Ma L,Wang G,Coe D,Ferro R,Falasca M,Buckley CD,Mauro C,Marelli-Berg FM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

11-0081 was used in Flow cytometry/Cell sorting to investigate role of the ubiquitously expressed Ant2 gene in animal development.

Tue Sep 01 00:00:00 EDT 2015

Imaging Tolerance Induction in the Classic Medawar Neonatal Mouse Model: Active Roles of Multiple F1-Donor Cell Types.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Bascom RA,Tao KS,Tollenaar SL,West LJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunocytochemistry

Tue Sep 01 00:00:00 EDT 2015

Imaging Tolerance Induction in the Classic Medawar Neonatal Mouse Model: Active Roles of Multiple F1-Donor Cell Types.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Bascom RA,Tao KS,Tollenaar SL,West LJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunocytochemistry

Tue Sep 01 00:00:00 EDT 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

11-0081 was used in Flow cytometry/Cell sorting to exhibit a novel vaccine platform for inducing robust T cell responses capable of protecting against heterologous influenza A challenges.

Fri Jul 10 00:00:00 EDT 2015

IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.

PLoS pathogens

Liu G,Xu J,Wu H,Sun D,Zhang X,Zhu X,Magez S,Shi M

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of IL-27 in African trypanosomes infection, showing that IL-27 signalling is crucial by preventing lethal effects of CD4+ T cells and IFN-γ.

Wed Jul 01 00:00:00 EDT 2015

T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue.

Journal of immunology (Baltimore, Md. : 1950)

Lebrun A,Portocarrero C,Kean RB,Barkhouse DA,Faber M,Hooper DC

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Sun Nov 01 00:00:00 EDT 2015

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.

Journal of immunology (Baltimore, Md. : 1950)

Bardina SV,Michlmayr D,Hoffman KW,Obara CJ,Sum J,Charo IF,Lu W,Pletnev AG,Lim JK

11-0081 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of inflammatory monocyte migration in West Nile Virus encephalitis, showing differential roles of CCL2 and CCL7 in monocytosis and leukocyte migration.

Sun Nov 01 00:00:00 EDT 2015

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.

Human vaccines & immunotherapeutics

Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Mar 11 00:00:00 EST 2016

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.

PloS one

Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Apr 28 00:00:00 EDT 2016

MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.

Stem cell reports

Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Nov 10 00:00:00 EST 2015

MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.

Stem cell reports

Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Nov 10 00:00:00 EST 2015

Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.

eLife

He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Dec 08 00:00:00 EST 2015

Development of an in vitro assay and demonstration of Plasmodium berghei liver-stage inhibition by TRAP-specific CD8+ T cells.

PloS one

Longley RJ,Bauza K,Ewer KJ,Hill AV,Spencer AJ

11-0081 was used in Immunocytochemistry to develop an in vitro T cell killing assay using a mouse hepatoma cell line, Hepa1-6, and Plasmodium berghei GFP expressing sporozoites.

Fri Apr 22 00:00:00 EDT 2016

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

11-0081-82 was used in Flow cytometry/Cell sorting to suggest that physiological differences between fibroblast-like cell populations might lie at the basis of variations in histopathological and/or clinical outcome following cell grafting in mouse brain.

Mon Nov 16 00:00:00 EST 2015

Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries.

Oncotarget

Huang HN,Chan YL,Hui CF,Wu JL,Wu CJ,Chen JY

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunohistochemistry

Sat May 30 00:00:00 EDT 2015

DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.

International journal of clinical and experimental medicine

Wang Q,Cao W,Yang ZG,Zhao GF

11-0081 was used in Flow cytometry/Cell sorting to show that DNA vaccine which targeting of dendritic cells in situ by the means of antibody-antigen conjugates may be a novel way to induce long-lasting antitumor immunity.

Fri Jan 15 00:00:00 EST 2016

The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.

Nature immunology

Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD

11-0081 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.

Wed Jan 01 00:00:00 EST 2014

Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.

Stem cells (Dayton, Ohio)

Povinelli BJ,Nemeth MJ

11-0081 was used in Flow Cytometry to study whether Ryk protein regulates the response of haematopoietic stem cells to Wnt5a.

Wed Jan 01 00:00:00 EST 2014

Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.

Laboratory investigation; a journal of technical methods and pathology

Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X

11-0081 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..

Sat Feb 01 00:00:00 EST 2014

An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G

11-0081 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.

Sat Mar 15 00:00:00 EDT 2014

Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M

11-0081 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.

Mon Sep 01 00:00:00 EDT 2014

Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

Journal of immunology (Baltimore, Md. : 1950)

Bökers S,Urbat A,Daniel C,Amann K,Smith KG,Espéli M,Nitschke L

11-0081 was used in Flow cytometry/Cell sorting to study how loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis.

Tue Apr 01 00:00:00 EDT 2014

Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.

Journal of immunology (Baltimore, Md. : 1950)

Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

11-0081 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.

Fri Aug 01 00:00:00 EDT 2014

Salidroside attenuates concanavalin A-induced hepatitis via modulating cytokines secretion and lymphocyte migration in mice.

Mediators of inflammation

Hu B,Zou Y,Liu S,Wang J,Zhu J,Li J,Bo L,Deng X

11-0081 was used in Flow cytometry/Cell sorting to study the modulation of cytokine secretion and lymphocyte migration in mice by the attenuation of concanavalin A-induced hepatitis by Salidroside.

Thu Dec 18 00:00:00 EST 2014

Immune selection of tumor cells in TCR β-chain transgenic mice.

Journal of immunotoxicology

Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB

11-0081 was used in Flow cytometry/Cell sorting to compare the ability of WT and transgenic, immune-compromised mice to reject EL4 thymoma cells.

Wed Oct 01 00:00:00 EDT 2014

Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection.

Particle and fibre toxicology

Lee GI,Saravia J,You D,Shrestha B,Jaligama S,Hebert VY,Dugas TR,Cormier SA

11-0081 was used in Flow cytometry/Cell sorting to study how EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.

Thu Oct 30 00:00:00 EDT 2014

Autophagy is a critical regulator of memory CD8(+) T cell formation.

eLife

Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK

11-0081 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.

Tue Nov 11 00:00:00 EST 2014

A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome.

Acta neuropathologica communications

Yang M,Rainone A,Shi XQ,Fournier S,Zhang J

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Jan 08 00:00:00 EST 2014

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.

Nature communications

Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM

11-0081 was used in Flow cytometry/Cell sorting to explain the mechanisms underlying the powerful migratory capacity of Treg cells and their ability to maintain optimal T cell ratios.

Fri Mar 14 00:00:00 EDT 2014

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.

BMC biology

Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R

11-0081 was used in Flow cytometry/Cell sorting to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.

Fri May 09 00:00:00 EDT 2014

Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.

PloS one

Funda DP,Fundova P,Hansen AK,Buschard K

11-0081 was used in Flow cytometry/Cell sorting to investigate whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process, showing that i.n. administration of gliadin prevents type 1 diabetes in NOD mice.

Tue Jan 13 00:00:00 EST 2015

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.

PloS one

Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

11-0081 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.

Mon Jul 06 00:00:00 EDT 2015

Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.

PloS one

Ikeda T,Hirata S,Takamatsu K,Haruta M,Tsukamoto H,Ito T,Uchino M,Ando Y,Nagafuchi S,Nishimura Y,Senju S

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of embryonic stem cell-derived dendritic cells on autoimmunity, showing that suppression of Th1-mediated autoimmunity occurs in NOD and EAE mice.

Thu Dec 17 00:00:00 EST 2015

Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis.

The Journal of biological chemistry

Bhattacharya A,Parillon X,Zeng S,Han S,Eissa NT

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Sep 19 00:00:00 EDT 2014

Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.

The Journal of biological chemistry

Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G

11-0081 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.

Fri Oct 31 00:00:00 EDT 2014

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.

Nature immunology

Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.

Nature immunology

Ji Q,Castelli L,Goverman JM

11-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the role of CD8(+) T cells in the pathogenesis of multiple sclerosis.

Fri Mar 01 00:00:00 EST 2013

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.

The Journal of experimental medicine

Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

11-0081 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.

Mon Apr 08 00:00:00 EDT 2013

Dose-dense chemotherapy improves mechanisms of antitumor immune response.

Cancer research

Chang CL,Hsu YT,Wu CC,Lai YZ,Wang C,Yang YC,Wu TC,Hung CF

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.

PLoS pathogens

Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P

11-0081 was used in Flow cytometry/Cell sorting to show that inactivation of Irf8 confers protection against the development of cerebral malaria.

Tue Feb 18 00:00:00 EST 2014

Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.

PLoS pathogens

Caignard G,Leiva-Torres GA,Leney-Greene M,Charbonneau B,Dumaine A,Fodil-Cornu N,Pyzik M,Cingolani P,Schwartzentruber J,Dupaul-Chicoine J,Guo H,Saleh M,Veillette A,Lathrop M,Blanchette M,Majewski J,Pearson A,Vidal SM

11-0081 was used in Flow cytometry/Cell sorting to identify host factors involved in HSV-1 and herpes simplex encephalitis susceptibility in an in vivo HSV-1 infectious model.

Sun Sep 01 00:00:00 EDT 2013

Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.

European journal of immunology

Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE

11-0081 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.

Fri Mar 01 00:00:00 EST 2013

Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice.

Journal of virology

Shen FH,Wang SW,Yeh TM,Tung YY,Hsu SM,Chen SH

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of the chemokine CXCL10 in the development of herpetic stromal keratitis.

Thu Aug 01 00:00:00 EDT 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin.

Journal of immunology (Baltimore, Md. : 1950)

Nayak JL,Alam S,Sant AJ

11-0081 was used in Flow cytometry/Cell sorting to evaluate the effect of competition between memory and naive lymphocytes on CD4 T cell and B cell response specificity using a murine model of sequential influenza infection.

Thu Aug 01 00:00:00 EDT 2013

Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.

Journal of immunology (Baltimore, Md. : 1950)

Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER

11-0081 was used in Flow cytometry/Cell sorting to demonstrate how CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.

Tue Jan 15 00:00:00 EST 2013

Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice.

American journal of physiology. Gastrointestinal and liver physiology

Takigawa T,Miyazaki H,Kinoshita M,Kawarabayashi N,Nishiyama K,Hatsuse K,Ono S,Saitoh D,Seki S,Yamamoto J

11-0081 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory effect of ursodeoxycholic acid on experimental hepatitis, endotoxin shock, and bacterial infection in mice.

Sun Sep 15 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3.

BMC infectious diseases

Zhang NZ,Huang SY,Zhou DH,Chen J,Xu Y,Tian WP,Lu J,Zhu XQ

11-0081 was used in Flow cytometry/Cell sorting to investigate the potentiality of protective immunity from DNA immunization, using the gene encoding calcium-dependent protein kinase 3.

Thu Oct 31 00:00:00 EDT 2013

Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells.

PloS one

Imai T,Koyanagi N,Ogawa R,Shindo K,Suenaga T,Sato A,Arii J,Kato A,Kiyono H,Arase H,Kawaguchi Y

11-0081 was used in Flow cytometry/Cell sorting to reveal that Us3 kinase activity is required for influencing cell surface expression for evasion of HSV-1-specific CD8(+) T cells.

Tue Apr 15 00:00:00 EDT 2014

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

PLoS genetics

Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Jun 13 00:00:00 EDT 2013

DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice.

BMC immunology

Cao J,Jin Y,Li W,Zhang B,He Y,Liu H,Xia N,Wei H,Yan J

11-0081 was used in Flow cytometry/Cell sorting to investigate anti-tumoural efficacy and underlying mechanisms of DC-targeting DNA vaccines in mouse breast cancer models, showing that it induces potent anti-tumour immunity in mice.

Wed Aug 14 00:00:00 EDT 2013

Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.

PloS one

Jupelli M,Shimada K,Chiba N,Slepenkin A,Alsabeh R,Jones HD,Peterson E,Chen S,Arditi M,Crother TR

11-0081 was used in Flow cytometry/Cell sorting to investigate how chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis..

Sat Aug 02 00:00:00 EDT 2014

Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice.

Oncoimmunology

Bandini S,Curcio C,Macagno M,Quaglino E,Arigoni M,Lanzardo S,Hysi A,Barutello G,Consolino L,Longo DL,Musiani P,Forni G,Iezzi M,Cavallo F

11-0081 was used in Flow cytometry/Cell sorting to assess the role of the complement system in the progression of carcinomas.

Sun Sep 01 00:00:00 EDT 2013

In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.

PloS one

Cabrera M,Pewe LL,Harty JT,Frevert U

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Tue Mar 18 00:00:00 EDT 2014

In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.

PloS one

Cabrera M,Pewe LL,Harty JT,Frevert U

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Immunofluorescence

Tue Mar 18 00:00:00 EDT 2014

A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.

PloS one

Schuster C,Brosi H,Stifter K,Boehm BO,Schirmbeck R

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Apr 08 00:00:00 EDT 2014

A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.

PloS one

Schuster C,Brosi H,Stifter K,Boehm BO,Schirmbeck R

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Apr 08 00:00:00 EDT 2014

Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.

Clinical & developmental immunology

Maes W,Verschuere T,Van Hoylandt A,Boon L,Van Gool S

11-0081 was used in Flow cytometry/Cell sorting to evaluate the local elimination of Tregs as a tool for augmentation of the antitumoural response.

Tue Dec 10 00:00:00 EST 2013

Transcription factor RORα is critical for nuocyte development.

Nature immunology

Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN

11-0081 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.

Sun Jan 22 00:00:00 EST 2012

Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.

Blood

Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L

11-0081-82 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.

Thu May 10 00:00:00 EDT 2012

Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.

Cellular & molecular immunology

Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.

Sun Jan 01 00:00:00 EST 2012

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

11-0081 was used in Flow cytometry/Cell sorting to identify a novel mutation in a GATA2 cis-element which causes deficits in haematopoietic stem/progenitor activity.

Mon Oct 01 00:00:00 EDT 2012

Regulatory T cells protect from autoimmune arthritis during pregnancy.

Journal of autoimmunity

Munoz-Suano A,Kallikourdis M,Sarris M,Betz AG

11-0081 was used in Flow cytometry/Cell sorting to study how regulatory T cells are responsible for the pregnancy-induced amelioration of arthritis.

Tue May 01 00:00:00 EDT 2012

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Oncogene

Darlington Y,Nguyen TA,Moon SH,Herron A,Rao P,Zhu C,Lu X,Donehower LA

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

The ubiquitin-like protein, ISG15, is a novel tumor-associated antigen for cancer immunotherapy.

Cancer immunology, immunotherapy : CII

Wood LM,Pan ZK,Seavey MM,Muthukumaran G,Paterson Y

11-0081 was used in Flow cytometry/Cell sorting to investigate ISG15, a novel tumor-associated antigen for cancer immunotherapy.

Tue May 01 00:00:00 EDT 2012

Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice.

Journal of immunology (Baltimore, Md. : 1950)

Iwata Y,Boström EA,Menke J,Rabacal WA,Morel L,Wada T,Kelley VR

11-0081 was used in Immunohistochemistry to elucidate the macrophage-associated effects of CSF-1 expression by tubular epithelial cells during kidney inflammation.

Tue May 01 00:00:00 EDT 2012

A critical role for Rictor in T lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P

11-0081 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.

Wed Aug 15 00:00:00 EDT 2012

Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.

International immunology

Iseki M,Omori-Miyake M,Xu W,Sun X,Takaki S,Rawlings DJ,Ziegler SF

11-0081 was used in Flow cytometry/Cell sorting to demonstrate that thymic stromal lymphopoietin levels are an important factor in B-cell homeostasis and humoral autoimmunity.

Thu Mar 01 00:00:00 EST 2012

The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells.

Molecular immunology

Aragon IV,Barrington RA,Jackowski S,Mori K,Brewer JW

11-0081 was used in Flow cytometry/Cell sorting to demonstrate that a specialised B cell UPR relies exclusively on the IRE1-XBP1 pathway to remodel the ER and expand secretory capacity.

Sun Jul 01 00:00:00 EDT 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2.

Journal of radiation research

Sonn CH,Choi JR,Kim TJ,Yu YB,Kim K,Shin SC,Park GH,Shirakawa T,Kim HS,Lee KM

11-0081 was used in Magnetic cell separation to demonstrate how exposure to LDR can lead to subtle immune-enhancing effects on NK cells.

Thu Nov 01 00:00:00 EDT 2012

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.

Genesis (New York, N.Y. : 2000)

Berquam-Vrieze KE,Swing DA,Tessarollo L,Dupuy AJ

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2012

The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells.

Viral immunology

Chentoufi AA,Dervillez X,Dasgupta G,Nguyen C,Kabbara KW,Jiang X,Nesburn AB,Wechsler SL,Benmohamed L

11-0081 was used in Flow cytometry/Cell sorting to study a novel immune-evasion mechanism whereby the HSV-1 LAT increases the number of HSV-1 Ag-positive DCs in latently-infected TG, and interferes with DC phenotypic and functional maturation.

Fri Jun 01 00:00:00 EDT 2012

Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging.

PloS one

Guo J,Feng Y,Barnes P,Huang FF,Idell S,Su DM,Shams H

11-0081 was used in Flow cytometry/Cell sorting to study reduction of peripheral T cell responses to infection and mimicry of changes of aging after deletion of FoxN1 in the thymic medullary epithelium.

Thu Aug 30 00:00:00 EDT 2012

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.

The Journal of biological chemistry

Badeaux AI,Yang Y,Cardenas K,Vemulapalli V,Chen K,Kusewitt D,Richie E,Li W,Bedford MT

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Mon Jan 02 00:00:00 EST 2012

RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.

Immunity

Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F

11-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.

Fri Mar 25 00:00:00 EDT 2011

Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.

The Journal of experimental medicine

Pyzik M,Charbonneau B,Gendron-Pontbriand EM,Babić M,Krmpotić A,Jonjić S,Vidal SM

11-0081 was used in Flow cytometry/Cell sorting to study how multiple activating Ly49 receptors may participate in H-2-dependent recognition of MCMV infection, providing a common mechanism of NK cell-mediated resistance against viral infection.

Mon May 09 00:00:00 EDT 2011

Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.

EMBO molecular medicine

Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Sat Jan 01 00:00:00 EST 2011

Development of a liver-specific Tet-on inducible system for AAV vectors and its application in the treatment of liver cancer.

Molecular therapy : the journal of the American Society of Gene Therapy

Vanrell L,Di Scala M,Blanco L,Otano I,Gil-Farina I,Baldim V,Paneda A,Berraondo P,Beattie SG,Chtarto A,Tenenbaum L,Prieto J,Gonzalez-Aseguinolaza G

11-0081 was used in Flow cytometry/Cell sorting to characterise an inducible hepatospecific system in comparison with an inducible ubiquitous expression system.

Fri Jul 01 00:00:00 EDT 2011

The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism.

Journal of virology

Chentoufi AA,Kritzer E,Tran MV,Dasgupta G,Lim CH,Yu DC,Afifi RE,Jiang X,Carpenter D,Osorio N,Hsiang C,Nesburn AB,Wechsler SL,BenMohamed L

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of ocular infection of HSV-1 strain 17syn+- on CD8 T cell exhaustion.

Thu Sep 01 00:00:00 EDT 2011

Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.

Cancer gene therapy

Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.

Wed Jun 01 00:00:00 EDT 2011

Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.

Cancer gene therapy

Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.

Wed Jun 01 00:00:00 EDT 2011

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD8a monoclonal antibody (Product # 11-0081-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.

Journal of immunology (Baltimore, Md. : 1950)

Schmidt NW,Harty JT

11-0081 was used in Flow cytometry/Cell sorting to investigate whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells, showing that attrition of Plasmodium-specific cells is rescued by booster immunisation.

Fri Apr 01 00:00:00 EDT 2011

Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunity.

Journal of immunology (Baltimore, Md. : 1950)

Schmidt NW,Butler NS,Harty JT

11-0081 was used in Flow cytometry/Cell sorting to investigate how the threshold of memory CD8 T cells required for protective immunity is influenced by Plasmodium-host interactions.

Sun May 15 00:00:00 EDT 2011

CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.

Journal of immunology (Baltimore, Md. : 1950)

Endharti AT,Okuno Y,Shi Z,Misawa N,Toyokuni S,Ito M,Isobe K,Suzuki H

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of CD8(+)CD122(+) regulatory T cells (Tregs) in maintenance of immune homeostasis, showing that CD8(+)CD122(+) Tregs and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.

Sat Jan 01 00:00:00 EST 2011

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Wang L,Du C,Lv J,Wei W,Cui Y,Xie X

11-0081 was used in Flow cytometry/Cell sorting to investigate how anti-asthmatic drugs targeting the cysteinyl leukotrine receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.

Thu Sep 01 00:00:00 EDT 2011

Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice.

Transplantation

Ji H,Shen XD,Gao F,Busuttil RW,Zhai Y,Kupiec-Weglinski JW

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of B cell deficiency in primed/memory CD8+ T cell responses and the mechanism of cardiac allograft rejection in sensitised mouse recipients.

Fri May 27 00:00:00 EDT 2011

A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice.

Toxicology

Mustafa A,Holladay SD,Witonsky S,Sponenberg DP,Karpuzoglu E,Gogal RM

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of prenatal TCDD on the postnatal autoimmune status of C57BL/6 mice.

Sun Dec 18 00:00:00 EST 2011

Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.

Infection and immunity

Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.

Tue Mar 01 00:00:00 EST 2011

Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice.

PloS one

Ohsugi T,Kumasaka T

11-0081 was used in Flow cytometry/Cell sorting to identify the primary T-cell subsets involved in the development of arthropathy in Tax transgenic mice.

Fri Apr 01 00:00:00 EDT 2011

T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.

Immunity

Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S

11-0081 was used in Flow cytometry/Cell sorting to explore the regulatory processes maintaining a tolerogenic attitude towards enteric commensal bacteria.

Wed Nov 24 00:00:00 EST 2010

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.

Proceedings of the National Academy of Sciences of the United States of America

Ma L,Mauro C,Cornish GH,Chai JG,Coe D,Fu H,Patton D,Okkenhaug K,Franzoso G,Dyson J,Nourshargh S,Marelli-Berg FM

11-0081 was used in Magnetic cell separation to investigate the contribution of CD31 to T-cell responses, showing that it plays a nonredundant role in the regulation of T-cell immunity and tolerance.

Tue Nov 09 00:00:00 EST 2010

T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America

Rodriguez-Manzanet R,Sanjuan MA,Wu HY,Quintana FJ,Xiao S,Anderson AC,Weiner HL,Green DR,Kuchroo VK

11-0081 was used in Flow cytometry/Cell sorting to investigate the significance of interactions between TIM-4 and phophatidylserine, showing that TIM-4 deficiency leads to T and B cell hyperactivity and autoimmunity.

Tue May 11 00:00:00 EDT 2010

Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses.

The Journal of infectious diseases

Singh R,Rothman AL,Potts J,Guirakhoo F,Ennis FA,Green S

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of immunisation with chimeric flaviviruses.

Thu Jul 15 00:00:00 EDT 2010

Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.

Cancer gene therapy

Whelan MC,Casey G,MacConmara M,Lederer JA,Soden D,Collins JK,Tangney M,O'Sullivan GC

11-0081 was used in Flow cytometry/Cell sorting to study the use of a combined immunogene therapy and regulatory T-cell inactivation against weakly immunogenic solid tumours.

Thu Jul 01 00:00:00 EDT 2010

Fine-scale staging of T cell lineage commitment in adult mouse thymus.

Journal of immunology (Baltimore, Md. : 1950)

Yui MA,Feng N,Rothenberg EV

11-0081 was used in Flow cytometry/Cell sorting to determine the gene regulatory changes that accompany commitment in adult wild-type double-negative adult thymocytes.

Thu Jul 01 00:00:00 EDT 2010

IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms.

Journal of immunology (Baltimore, Md. : 1950)

Sorensen EW,Gerber SA,Frelinger JG,Lord EM

11-0081 was used in Flow cytometry/Cell sorting to determine how IL-12 exerts an antiangiogenic effect on tumour blood vessels.

Mon Feb 15 00:00:00 EST 2010

Direct presentation regulates the magnitude of the CD8+ T cell response to cell-associated antigen through prolonged T cell proliferation.

Journal of immunology (Baltimore, Md. : 1950)

Tatum AM,Watson AM,Schell TD

11-0081 was used in Flow cytometry/Cell sorting to reveal that direct presentation by nonprofessional APCs can dramatically enhance accumulation of CD8(+) T cells during primary response.

Wed Sep 01 00:00:00 EDT 2010

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B

11-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.

Mon Feb 15 00:00:00 EST 2010

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.

International immunology

Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN

11-0081 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.

Thu Apr 01 00:00:00 EDT 2010

Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.

Mediators of inflammation

Gomez CR,Karavitis J,Palmer JL,Faunce DE,Ramirez L,Nomellini V,Kovacs EJ

11-0081 was used in Flow cytometry/Cell sorting to demonstrate in vitro that Interleukin-6 regulates age-related defects in splenic macrophages through alteration of proinflammatory cytokines.

Thu Nov 04 00:00:00 EDT 2010

Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins.

Viral immunology

Nayak JL,Richards KA,Chaves FA,Sant AJ

11-0081 was used in Flow cytometry/Cell sorting to investigate how the distribution of CD4 T-cell specificities for different influenza proteins varied significantly depending on the single class II molecule expressed in vivo.

Thu Apr 01 00:00:00 EDT 2010

Thymic alterations in GM2 gangliosidoses model mice.

PloS one

Kanzaki S,Yamaguchi A,Yamaguchi K,Kojima Y,Suzuki K,Koumitsu N,Nagashima Y,Nagahama K,Ehara M,Hirayasu Y,Ryo A,Aoki I,Yamanaka S

11-0081 was used in Flow cytometry/Cell sorting to study the Hexb(-/-) mouse model of Sandhoff disease, showing alterations to the thymus, potentially due to FcRγ.

Tue Aug 10 00:00:00 EDT 2010

Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection.

Brain, behavior, and immunity

Steelman AJ,Dean DD,Young CR,Smith R,Prentice TW,Meagher MW,Welsh CJ

11-0081 was used in Flow cytometry/Cell sorting to examine how stress during acute TMEV infection alters virus-specific cell mediated responses, showing that stress-induced immunosuppression enhances viral persistence.

Sat Aug 01 00:00:00 EDT 2009

In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

The Journal of experimental medicine

Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J

11-0081 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.

Mon Apr 13 00:00:00 EDT 2009

Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.

Diabetes

Parker MJ,Xue S,Alexander JJ,Wasserfall CH,Campbell-Thompson ML,Battaglia M,Gregori S,Mathews CE,Song S,Troutt M,Eisenbeis S,Williams J,Schatz DA,Haller MJ,Atkinson MA

11-0081 was used in Flow cytometry/Cell sorting to investigate the use of ATG and GCSF in therapies to reverse overt hyperglycaemia in a diabetic mouse model.

Thu Oct 01 00:00:00 EDT 2009

Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.

European journal of immunology

Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H

11-0081-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.

Sat Aug 01 00:00:00 EDT 2009

Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.

Journal of leukocyte biology

Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D

11-0081 was used in Flow cytometry/Cell sorting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..

Tue Sep 01 00:00:00 EDT 2009

Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma.

Arthritis research & therapy

Kelchtermans H,Schurgers E,Geboes L,Mitera T,Van Damme J,Van Snick J,Uyttenhove C,Matthys P

11-0081 was used in Flow cytometry/Cell sorting to analyse the mechanisms of action of IL-17 in arthritis and the effect of IFN-gamma on those mechanisms.

Wed Dec 16 00:00:00 EST 2009

c-Myb is required for pro-B cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Fahl SP,Crittenden RB,Allman D,Bender TP

11-0081 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.

Sun Nov 01 00:00:00 EDT 2009

The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.

Journal of immunology (Baltimore, Md. : 1950)

Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL

11-0081 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.

Sun Feb 01 00:00:00 EST 2009

Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.

Journal of immunology (Baltimore, Md. : 1950)

Farrand KJ,Dickgreber N,Stoitzner P,Ronchese F,Petersen TR,Hermans IF

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of langerin(+)CD8alpha(+) dendritic cells in priming T cells, showing that they are critical for cross-priming and IL-12 production in response to systemic antigens.

Tue Dec 15 00:00:00 EST 2009

Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy.

Journal of immunology (Baltimore, Md. : 1950)

Broomfield SA,van der Most RG,Prosser AC,Mahendran S,Tovey MG,Smyth MJ,Robinson BW,Currie AJ

11-0081 was used in Flow cytometry/Cell sorting to show that locally delivered TLR7 agonist imiquimod in conjuction with systemic anti-CD40 immunotherapy significantly enhances the local antitumor response and retards growth of distal tumors.

Fri May 01 00:00:00 EDT 2009

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

Journal of immunology (Baltimore, Md. : 1950)

Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.

Wed Jul 15 00:00:00 EDT 2009

Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.

Journal of immunology (Baltimore, Md. : 1950)

Maroof A,Beattie L,Kirby A,Coles M,Kaye PM

11-0081 was used in Flow cytometry/Cell sorting to study how inflammation-matured DCs can induce Ag-independent T cell proliferation.

Tue Dec 01 00:00:00 EST 2009

NKG2A inhibits invariant NKT cell activation in hepatic injury.

Journal of immunology (Baltimore, Md. : 1950)

Kawamura T,Takeda K,Kaneda H,Matsumoto H,Hayakawa Y,Raulet DH,Ikarashi Y,Kronenberg M,Yagita H,Kinoshita K,Abo T,Okumura K,Smyth MJ

11-0081 was used in Flow cytometry/Cell sorting to investigate the role of NK cell receptors in iNKT cell activation, showing that NKG2A-mediated signalling negatively regulated iNKT activation and hepatic injury.

Thu Jan 01 00:00:00 EST 2009

Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection.

Infection and immunity

Bou Ghanem EN,McElroy DS,D'Orazio SE

11-0081 was used in Flow cytometry/Cell sorting to demonstrate the numerous pathways leading to the secretion of IFN-gamma by CD8+ T cells during infection.

Wed Apr 01 00:00:00 EDT 2009

CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.

Journal of the American Society of Nephrology : JASN

Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR

11-0081 was used in Flow cytometry/Cell sorting to identify additional therapeutic chemokine targets for immune-mediated nephritis.

Sun Jun 01 00:00:00 EDT 2008

Containment of tumor-colonizing bacteria by host neutrophils.

Cancer research

Westphal K,Leschner S,Jablonska J,Loessner H,Weiss S

11-0081 was used in Flow cytometry/Cell sorting to study the ability of host neutrophils to contain tumour-colonising bacteria, and how bacteria-mediated tumour therapy may be amplified by depletion of host neutrophils.

Tue Apr 15 00:00:00 EDT 2008

Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia.

Microbes and infection

Wang SH,Zhang C,Lasbury ME,Liao CP,Durant PJ,Tschang D,Lee CH

11-0081 was used in Flow cytometry/Cell sorting to show that TLR2-mediated inflammatory responses contribute to the clearance of Pneumocystis.

Tue Apr 01 00:00:00 EDT 2008

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.

European journal of immunology

White AJ,Withers DR,Parnell SM,Scott HS,Finke D,Lane PJ,Jenkinson EJ,Anderson G

11-0081 was used in Flow cytometry/Cell sorting to analyse the cellular and molecular requirements for the initial appearance of Aire+ medullary thymic epithelial cells in the embryonic thymus, in addition to their persistence in the adult thymus.

Tue Apr 01 00:00:00 EDT 2008

Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.

Journal of virology

Sridhar S,Reyes-Sandoval A,Draper SJ,Moore AC,Gilbert SC,Gao GP,Wilson JM,Hill AV

11-0081 was used in Flow cytometry/Cell sorting to compare efficacy of AdH5 and AdC6 vector vaccines expressing antigen under HCMV promotion.

Tue Apr 01 00:00:00 EDT 2008

Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.

Journal of immunology (Baltimore, Md. : 1950)

Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A

11-0081 was used in Flow cytometry/Cell sorting to determine that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression.

Sat Nov 01 00:00:00 EDT 2008

Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.

Journal of immunology (Baltimore, Md. : 1950)

Lukens JR,Cruise MW,Lassen MG,Hahn YS

11-0081 was used in Flow cytometry/Cell sorting to determine the mechanism of the hepatitis C virus core in suppressing Ag-specific CD8(+) T cell responses.

Tue Apr 01 00:00:00 EDT 2008

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection.

International journal for parasitology

Wanasen N,Xin L,Soong L

11-0081 was used in Flow cytometry/Cell sorting to suggest that B cell activity enhances L. amazonensis infection by promoting T cell priming and cellular migration to the infection site.

Sat Mar 01 00:00:00 EST 2008

Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection.

International journal for parasitology

Wanasen N,Xin L,Soong L

11-0081 was used in Flow cytometry/Cell sorting to suggest that B cell activity enhances L. amazonensis infection by promoting T cell priming and cellular migration to the infection site.

Sat Mar 01 00:00:00 EST 2008

Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response.

Infection and immunity

Guerrero A,Fries BC

11-0081 was used in Flow cytometry/Cell sorting to compare survival rates and characterise the host responses of C. neoformans-resistant mice.

Mon Sep 01 00:00:00 EDT 2008

Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.

Journal of medical microbiology

Chaitra MG,Shaila MS,Nayak R

11-0081 was used in Flow cytometry/Cell sorting to demonstrate the immunogenicity of two PE/PPE proteins in BALB/c mice.

Mon Sep 01 00:00:00 EDT 2008

Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein.

Clinical and vaccine immunology : CVI

Liao JB,Publicover J,Rose JK,DiMaio D

11-0081 was used in Flow cytometry/Cell sorting to demonstrate the antitumor responses to HPV16 E7, suggesting that recombinant-VSV-based vaccination could be explored as a therapeutic strategy for HPV-associated cancers.

Thu May 01 00:00:00 EDT 2008

PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches.

Blood

Jenkinson WE,Rossi SW,Parnell SM,Jenkinson EJ,Anderson G

11-0081 was used in Flow cytometry/Cell sorting to study the regulation of thymus growth and the availability of intrathymic niches by pdgfralpha-expressing mesenchyme.

Thu Feb 01 00:00:00 EST 2007

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.

Blood

White A,Carragher D,Parnell S,Msaki A,Perkins N,Lane P,Jenkinson E,Anderson G,Caamaño JH

11-0081 was used in Flow cytometry/Cell sorting to further investigate the mechanisms that regulate the development of stromal organiser cells.

Sat Sep 15 00:00:00 EDT 2007

Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues.

Molecular and cellular biology

Meuter S,Schaerli P,Roos RS,Brandau O,Bösl MR,von Andrian UH,Moser B

11-0081 was used in Flow cytometry/Cell sorting to investigate the process of dendritic cell recruitment to peripheral tissues, showing that murine CXCL14 is dispensable for dendritic cell function and localisation.

Thu Feb 01 00:00:00 EST 2007

Evaluation of T-cell responses to peptides with MHC class I-binding motifs derived from PE_PGRS 33 protein of Mycobacterium tuberculosis.

Journal of medical microbiology

Chaitra MG,Shaila MS,Nayak R

11-0081 was used in Flow cytometry/Cell sorting to study how PE_PGRS 33 has access to the MHC class I processing pathway, and how short peptide fragments of this protein can be presented to CD8+ T cells.

Sun Apr 01 00:00:00 EDT 2007

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.

International immunology

Tellier J,van Meerwijk JP,Romagnoli P

11-0081 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.

Wed Nov 01 00:00:00 EST 2006

An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.

International immunology

Tellier J,van Meerwijk JP,Romagnoli P

11-0081 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.

Wed Nov 01 00:00:00 EST 2006

Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.

The Journal of experimental medicine

Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF

11-0081 was used in Flow cytometry/Cell sorting to demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin of transgenic mice.

Mon Aug 15 00:00:00 EDT 2005

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

Genes & development

Taghon TN,David ES,Zúñiga-Pflücker JC,Rothenberg EV

11-0081 was used in Flow cytometry/Cell sorting to study how Notch/Delta signaling is not sufficient for T-lineage specification and commitment, but can be permissive for the maintenance and proliferation of uncommitted progenitors.

Fri Apr 15 00:00:00 EDT 2005

TOX provides a link between calcineurin activation and CD8 lineage commitment.

The Journal of experimental medicine

Aliahmad P,O'Flaherty E,Han P,Goularte OD,Wilkinson B,Satake M,Molkentin JD,Kaye J

11-0081 was used in Flow cytometry/Cell sorting to demonstrate that up-regulation of TOX in double positive thymocytes is calcineurin dependent, linking the signalling pathway to nuclear changes that occur during positive thymocyte selection..

Mon Apr 19 00:00:00 EDT 2004

Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis.

The Journal of experimental medicine

Rifa'i M,Kawamoto Y,Nakashima I,Suzuki H

11-0081 was used in Flow cytometry/Cell sorting to investigate the effect of transfer of CD8+CD122+ cells into CD122-deficient neonates, showing that CD8+CD122+ regulatory T cells are essential for T cell homeostasis.

Mon Nov 01 00:00:00 EST 2004

Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.

The American journal of pathology

Kawai H,Sato W,Yuzawa Y,Kosugi T,Matsuo S,Takei Y,Kadomatsu K,Muramatsu T

11-0081 was used in Immunohistochemistry on frozen tissues to investigate the significance of the secondary effects of cisplatin on proximal tubule survival.

Mon Nov 01 00:00:00 EST 2004

Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development.

Blood

Hsu SC,Wu CC,Han J,Lai MZ

11-0081 was used in Western Blotting to demonstrate that, in addition to early thymocyte development, p38 is involved in positive selection.

Sat Feb 01 00:00:00 EST 2003

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

11-0081 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

11-0081 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

11-0081 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Bioinformatics

Protein Aliases: CD8a; CD8alpha; CD8b; CD8beta; fCD8; Leu-2; leu-2a; Lymphocyte antigen 3; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3

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Gene Aliases: BB154331; Cd8a; Cd8b; Cd8b1; Ly-2; Ly-3; Ly-35; Ly-B; Ly-C; Lyt-2; Lyt-3; Lyt2; Lyt3

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UniProt ID: (Mouse) P01731, (Mouse) P10300

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Entrez Gene ID: (Mouse) 12525, (Mouse) 12526

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Function(s)

protein binding protein kinase binding protein homodimerization activity defense/immunity protein immunoglobulin receptor superfamily

Process(es)

immune system process T cell mediated immunity cell surface receptor signaling pathway T cell activation cytotoxic T cell differentiation positive regulation of calcium-mediated signaling defense response to virus

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CD8a Monoclonal Antibody (53-6.7), FITC, eBioscience™

CD8a Antibody (11-0081-82) in Flow

Product Details

11-0081-82

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Functional Assay (Functional)

Miscellaneous PubMed (Misc)

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