Product References
Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice.
Nature communications
Cheong LY,Wang B,Wang Q,Jin L,Kwok KHM,Wu X,Shu L,Lin H,Chung SK,Cheng KKY,Hoo RLC,Xu A
45-0451-82 was used in Flow cytometry/Cell sorting to identify fibroblastic reticular cells (FRCs) in inguinal LNs (iLNs) as a major source of IL-33 in mediating cold-induced beiging and thermogenesis of subcutaneous WAT (scWAT).
Fri Mar 03 00:00:00 EST 2023
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
British journal of pharmacology
Liu LW,Xie Y,Li GQ,Zhang T,Sui YH,Zhao ZJ,Zhang YY,Yang WB,Geng XL,Xue DB,Chen H,Wang YW,Lu TQ,Shang LR,Li ZB,Li L,Sun B
45-0451-82 was used in Flow cytometry/Cell sorting to investigate the effect of gut microbiota and microbiota-derived metabolites on AP and further clarify the mechanisms associated with pancreatic damage and inflammation.
Wed Mar 01 00:00:00 EST 2023
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
Nature communications
Onyishi CU,Desanti GE,Wilkinson AL,Lara-Reyna S,Frickel EM,Fejer G,Christophe OD,Bryant CE,Mukhopadhyay S,Gordon S,May RC
45-0451-82 was used in Flow cytometry/Cell sorting to indicate a hitherto unidentified role for TLR4/MSR1 crosstalk in the non-opsonic phagocytosis of C. neoformans.
Mon Aug 14 00:00:00 EDT 2023
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model.
Frontiers in cellular neuroscience
MacPherson KP,Eidson LN,Houser MC,Weiss BE,Gollihue JL,Herrick MK,de Sousa Rodrigues ME,Sniffen L,Weekman EM,Hamilton AM,Kelly SD,Oliver DL,Yang Y,Chang J,Sampson TR,Norris CM,Tansey MG
45-0451-82 was used in Flow cytometry/Cell sorting to show that selective inhibition of soluble tumor necrosis factor signaling via the biologic XPro1595 modulates the effects of an high in fat and sugar (HFHS) diet in 5xFAD mice on peripheral and central immune profiles including CNS-associated CD8+ T cells, the composition of gut microbiota, and long-term potentiation deficits.
Sun May 12 00:00:00 EDT 2024
Vector Aided Microenvironment programming (VAMP): reprogramming the TME with MVA virus expressing IL-12 for effective antitumor activity.
Journal for immunotherapy of cancer
Seclì L,Infante L,Nocchi L,De Lucia M,Cotugno G,Leoni G,Micarelli E,Garzia I,Avalle L,Sdruscia G,Troise F,Allocca S,Romano G,Scarselli E,D'Alise AM
45-0451-82 was used in Flow cytometry/Cell sorting to show that TME switch from immunosuppressive into immunostimulatory environment allowed for CD8 T cells priming and expansion leading to tumor attack.
Sat Apr 01 00:00:00 EDT 2023
Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity.
Cell research
Zhou C,Ma L,Xu H,Huo Y,Luo J
45-0451-82 was used in Flow Cytometry to suggest an essential role of the MLV-CLN network in RT-triggered anti-tumor immunity, and highlight the potential of VEGF-C mRNA for brain tumor therapy.
Wed Jun 01 00:00:00 EDT 2022
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
45-0451-82 was used in Flow Cytometry to establish a tumor-suppressive function of WHSC1 that relays IFN-γ signaling to promote antigen presentation in CRC cells, and provide a rationale for boosting WHSC1 activity in immunotherapy.
Fri Apr 15 00:00:00 EDT 2022
PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer.
Nature communications
Kim DK,Jeong J,Lee DS,Hyeon DY,Park GW,Jeon S,Lee KB,Jang JY,Hwang D,Kim HM,Jung K
45-0451-82 was used in Flow cytometry/Cell sorting to study the mechanism underlying chemotherapy-induced fibrosis in PDAC.
Sat Oct 22 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
45-0451-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
45-0451-82 was used in Flow Cytometry to show that sub-chronic stress increased sphingosine-1-phosphate (S1P) in the mouse colon, possibly due to a decrease in its degradation enzymes and sphingosine kinase 2 (Sphk2).
Tue Mar 08 00:00:00 EST 2022
Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.
Scientific reports
Beiter RM,Rivet-Noor C,Merchak AR,Bai R,Johanson DM,Slogar E,Sol-Church K,Overall CC,Gaultier A
45-0451-82 was used in Flow cytometry/Cell sorting to investigate the exact mechanisms through which Oligodendrocyte progenitor cells might influence brain function.
Thu Jul 28 00:00:00 EDT 2022
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Cell stem cell
Zhang D,Gao X,Li H,Borger DK,Wei Q,Yang E,Xu C,Pinho S,Frenette PS
45-0451-82 was used in Flow cytometry/Cell sorting to reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
Thu Feb 03 00:00:00 EST 2022
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.
Molecular therapy oncolytics
Kim TW,Kim Y,Keum H,Jung W,Kang M,Jon S
45-0451-82 was used in Flow cytometry/Cell sorting to investigate the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.
Thu Sep 15 00:00:00 EDT 2022
Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.
Nature cancer
Shen M,Smith HA,Wei Y,Jiang YZ,Zhao S,Wang N,Rowicki M,Tang Y,Hang X,Wu S,Wan L,Shao ZM,Kang Y
45-0451-82 was used in Flow Cytometry to reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer.
Sat Jan 01 00:00:00 EST 2022
Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
Frontiers in endocrinology
Yang Y,Liu H,Zhao Y,Geng C,Chao L,Hao A
45-0451-82 was used in Flow cytometry/Cell sorting to reveal that Grim-19 deficiency influences macrophage function, characterized by enhanced proinflammatory cytokines and phagocytic activity, and this might be regulated by autophagy.
Tue Nov 22 00:00:00 EST 2022
STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao Y,Ma C,Chen C,Li S,Wang Y,Yang T,Stetler RA,Bennett MVL,Dixon CE,Chen J,Shi Y
45-0451-82 was used in Flow cytometry/Cell sorting to show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain injury using a mouse model, presenting STAT1 as a promising therapeutic target for TBI.
Wed Sep 28 00:00:00 EDT 2022
Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function.
Haematologica
Gomes AL,Gribben J,Siow B,Passaro D,Bonnet D
45-0451-82 was used in Flow Cytometry to show that dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) can quantify the impact of human acute myeloid leukemia (AML) on bone marrow (BM) vasculature by optimizing an in vivo DCE-MRI method and assessing the method’s diagnostic and prognostic potential.
Sun Aug 01 00:00:00 EDT 2021
Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury.
Nature communications
Honda M,Kadohisa M,Yoshii D,Komohara Y,Hibi T
45-0451-82 was used in flow cytometry experiments to show, using spinning-disk confocal microscopy, that large F4/80hiGATA6+ peritoneal cavity macrophages promptly accumulate at damaged intestinal sites upon intestinal thermal injury and upon dextran sodium sulfate induced colitis in mice via a direct route from the peritoneal cavity.
Wed Dec 15 00:00:00 EST 2021
Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity.
eLife
Shani O,Raz Y,Monteran L,Scharff Y,Levi-Galibov O,Megides O,Shacham H,Cohen N,Silverbush D,Avivi C,Sharan R,Madi A,Scherz-Shouval R,Barshack I,Tsarfaty I,Erez N
45-0451-82 was used in Flow Cytometry to identify Myc as a central regulator of fibroblast rewiring and found that stromal upregulation of Myc transcriptional networks is associated with disease progression in human breast cancer.
Fri Jun 25 00:00:00 EDT 2021
Potential role of senescent macrophages in radiation-induced pulmonary fibrosis.
Cell death & disease
Su L,Dong Y,Wang Y,Wang Y,Guan B,Lu Y,Wu J,Wang X,Li D,Meng A,Fan F
45-0451-82 was used in Flow Cytometry to provide important evidence that senescent macrophages might be the target for prevention and treatment of RIPF.
Sat May 22 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
45-0451-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
Ly6chi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice.
Kidney360
Aloria EJG,Song CJ,Li Z,Croyle MJ,Mrug M,Zimmerman KA,Yoder BK
45-0451-82 was used in Flow Cytometry to study how Ccr2-dependent, Ly6chi infiltrating macrophages promote cyst progression in the injury-accelerated, adult-induced, conditional Ift88 model of cystic disease.
Thu Jun 24 00:00:00 EDT 2021
Hypoxia depletes contaminating CD45+ hematopoietic cells from murine bone marrow stromal cell (BMSC) cultures: Methods for BMSC culture purification.
Stem cell research
Guo W,Spiller KV,Tang J,Karner CM,Hilton MJ,Wu C
45-0451-82 was used in Flow cytometry/Cell sorting to demonstrate a simple and reliable method exploiting the divergent biological response of hematopoietic and stromal cells to hypoxia to significantly increase the PDGFR α+ stromal cell population in murine BMSC cultures.
Sat May 01 00:00:00 EDT 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
45-0451-82 was used in Flow cytometry/Cell sorting to assess the sphingosine-1-phosphate receptor modulator fingolimod as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical recommendations.
Tue Jun 01 00:00:00 EDT 2021
Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.
PloS one
Ozen M,Zhao H,Kalish F,Yang Y,Jantzie LL,Wong RJ,Stevenson DK
45-0451-82 was used in Flow Cytometry to investigate the effects of an exposure to systemic inflammation late in gestation on wild-type and heme oxygenase-1 heterozygous mouse mothers, foetuses and offspring.
Wed Nov 17 00:00:00 EST 2021
Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice.
Cell research
Cai Y,Zhou H,Zhu Y,Sun Q,Ji Y,Xue A,Wang Y,Chen W,Yu X,Wang L,Chen H,Li C,Luo T,Deng H
45-0451 was used in Flow cytometry/Cell sorting to investigate if lysosomal β-gal can be effectively leveraged to selectively eliminate senescent cells, thus providing a novel strategy to develop anti-aging interventions.
Wed Jul 01 00:00:00 EDT 2020
Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.
Gastroenterology
Perusina Lanfranca M,Zhang Y,Girgis A,Kasselman S,Lazarus J,Kryczek I,Delrosario L,Rhim A,Koneva L,Sartor M,Sun L,Halbrook C,Nathan H,Shi J,Crawford HC,Pasca di Magliano M,Zou W,Frankel TL
45-0451-82 was used in Flow Cytometry to perform immunohistochemical analyses of 26 pancreatic ductal adenocarcinoma and 5 nonneoplastic pancreas specimens.
Wed Apr 01 00:00:00 EDT 2020
IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.
Arteriosclerosis, thrombosis, and vascular biology
Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that IgE deficiency reduced atherosclerosis lesion burden, lesion lipid deposition, smooth muscle cell and endothelial cell contents, chemokine MCP (monocyte chemoattractant protein)-1 expression and macrophage accumulation.
Sun Mar 01 00:00:00 EST 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
45-0451 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Jiang L,Mu H,Xu F,Xie D,Su W,Xu J,Sun Z,Liu S,Luo J,Shi Y,Leak RK,Wechsler LR,Chen J,Hu X
45-0451-82 was used in Flow Cytometry to provide a new resource to understand the mechanisms underlying microglial alterations in the aged brain milieu and sheds light on new strategies to improve microglial functions in aged stroke victims.
Tue Dec 01 00:00:00 EST 2020
Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Deng Z,Zhang X,Liu F,Yang C,Shi GP
45-0451 was used in Flow cytometry/Cell sorting to support a direct role of IgE in abdominal aortic aneurysm by promoting lesion chemokine expression, inflammatory cell accumulation, MAPK signalling and cytokine expression in mice.
Sat Feb 01 00:00:00 EST 2020
Recombinant programmed cell death 1 inhibits psoriatic inflammation in imiquimod‑treated mice.
International journal of molecular medicine
Peng S,Cao M,Sun X,Zhou Y,Chen CY,Ma T,Li H,Li B,Zhu B,Li X
45-0451-82 was used in Flow Cytometry to demonstrate that inhibition of PD‚1 function with antibodies promoted psoriasis development.
Sat Aug 01 00:00:00 EDT 2020
Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury.
eLife
Niethamer TK,Stabler CT,Leach JP,Zepp JA,Morley MP,Babu A,Zhou S,Morrisey EE
45-0451 was used in Flow cytometry/Cell sorting to identify that different subtypes of endothelial cells exist in capillaries, and that some may be able to perform slightly different jobs during lung recovery.
Mon Feb 24 00:00:00 EST 2020
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.
Nature communications
Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity.
Mon Jun 22 00:00:00 EDT 2020
The micropeptide LEMP plays an evolutionarily conserved role in myogenesis.
Cell death & disease
Wang L,Fan J,Han L,Qi H,Wang Y,Wang H,Chen S,Du L,Li S,Zhang Y,Tang W,Ge G,Pan W,Hu P,Cheng H
45-0451 was used in Flow cytometry/Cell sorting to uncover a micropeptide that plays an evolutionarily conserved role in skeletal muscle differentiation, pinpointing the functional importance of this growing family of small peptides.
Mon May 11 00:00:00 EDT 2020
Evaluating the efficacy of enzalutamide and the development of resistance in a preclinical mouse model of type-I endometrial carcinoma.
Neoplasia (New York, N.Y.)
Koivisto CS,Parrish M,Bonala SB,Ngoi S,Torres A,Gallagher J,Sanchez-Hodge R,Zeinner V,Nahhas GJ,Liu B,Cohn DE,Backes FJ,Goodfellow PJ,Chamberlin HM,Leone G
45-0451 was used in Flow cytometry/Cell sorting to show that enzalutamide induces apoptosis in EMC but has limited efficacy overall as a single agent.
Thu Oct 01 00:00:00 EDT 2020
Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.
Cell
Ponzetta A,Carriero R,Carnevale S,Barbagallo M,Molgora M,Perucchini C,Magrini E,Gianni F,Kunderfranco P,Polentarutti N,Pasqualini F,Di Marco S,Supino D,Peano C,Cananzi F,Colombo P,Pilotti S,Alomar SY,Bonavita E,Galdiero MR,Garlanda C,Mantovani A,Jaillon S
45-0451-82 was used in Flow Cytometry to conclude that neutrophils driving UTCαβ polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.
Thu Jul 11 00:00:00 EDT 2019
Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells.
Nature cell biology
Nakahara F,Borger DK,Wei Q,Pinho S,Maryanovich M,Zahalka AH,Suzuki M,Cruz CD,Wang Z,Xu C,Boulais PE,Ma'ayan A,Greally JM,Frenette PS
45-0451-82 was used in Flow Cytometry to provide insight into the transcriptional regulation of the niche with implications for stem cell-based therapies.
Wed May 01 00:00:00 EDT 2019
Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion.
Cancer research
Li F,Kitajima S,Kohno S,Yoshida A,Tange S,Sasaki S,Okada N,Nishimoto Y,Muranaka H,Nagatani N,Suzuki M,Masuda S,Thai TC,Nishiuchi T,Tanaka T,Barbie DA,Mukaida N,Takahashi C
45-0451 was used in Flow cytometry/Cell sorting to show that inactivation of the tumour suppressor retinoblastoma leads to a protumoral microenvironment via an increase in the secretion of the chemoattractant CCL2.
Thu Aug 01 00:00:00 EDT 2019
Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell-Mediated Tumor Regression in the MB49 Bladder Cancer Model.
Cancer immunology research
Domingos-Pereira S,Sathiyanadan K,La Rosa S,Polák L,Chevalier MF,Martel P,Hojeij R,Derré L,Haefliger JA,Jichlinski P,Nardelli-Haefliger D
45-0451 was used in Flow cytometry/Cell sorting to demonstrate mechanisms behind intravesical Ty21a therapy and suggest its potential as a safe and effective treatment for NMIBC patients.
Mon Apr 01 00:00:00 EDT 2019
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
PLoS pathogens
Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA
45-0451 was used in Flow cytometry/Cell sorting to show ROP16III in type III strain Toxoplasma gondii can influence the subacute CNS immune response and mediate parasitic survival and persistence.
Tue Oct 01 00:00:00 EDT 2019
Macrophages reprogram after ischemic stroke and promote efferocytosis and inflammation resolution in the mouse brain.
CNS neuroscience & therapeutics
Zhang W,Zhao J,Wang R,Jiang M,Ye Q,Smith AD,Chen J,Shi Y
45-0451-82 was used in Flow Cytometry to examine the transcriptomic changes in monocytes/macrophages after ischemic stroke and the functional implications of these changes, particularly with regards to the contribution of these cells to the phagocytic clearance of dead/dying cells (efferocytosis) in the poststroke brain.
Sun Dec 01 00:00:00 EST 2019
Spinal Motor Circuit Synaptic Plasticity after Peripheral Nerve Injury Depends on Microglia Activation and a CCR2 Mechanism.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rotterman TM,Akhter ET,Lane AR,MacPherson KP,García VV,Tansey MG,Alvarez FJ
45-0451 was used in Flow cytometry/Cell sorting to show that both activation of ventral microglia and a CCR2-dependent mechanism are necessary for removal of VGLUT1 synapses and alterations in Ia-circuit function following nerve injuries.
Wed May 01 00:00:00 EDT 2019
Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.
Journal of cellular and molecular medicine
Gu AQ,Li DD,Wei DP,Liu YQ,Ji WH,Yang Y,Lin HY,Peng JP
45-0451 was used in Flow cytometry/Cell sorting to study the relationship between cytochrome P450 26A1 and immune cells during the peri-implantation period in mice.
Thu Aug 01 00:00:00 EDT 2019
Atherogenesis in the Carotid Artery with and without Interrupted Blood Flow of Two Hyperlipidemic Mouse Strains.
Journal of vascular research
Zhao J,Huangfu C,Chang Z,Grainger AT,Liu Z,Shi W
45-0451 was used in Flow cytometry/Cell sorting to examine artherogenesis in the left carotid artery with and without interrupted blood flow using mouse models.
Mon Jan 27 00:00:00 EST 2020
Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.
Cell reports
Tuit S,Salvagno C,Kapellos TS,Hau CS,Seep L,Oestreich M,Klee K,de Visser KE,Ulas T,Schultze JL
45-0451 was used in Flow cytometry/Cell sorting to show that a transgenic mouse tumor model can yield a TAM signature relevant for human breast cancer outcome prognosis and provide a generalizable strategy for determining and applying immune cell signatures provided the murine model reflects the human disease.
Tue Oct 29 00:00:00 EDT 2019
The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression.
Nature communications
Huang J,Zhao L,Fan Y,Liao L,Ma PX,Xiao G,Chen D
45-0451-82 was used in Flow Cytometry to report that two homologous microRNAs, miR-204 and miR-211, maintain joint homeostasis to suppress OA pathogenesis.
Fri Jun 28 00:00:00 EDT 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
45-0451 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.
Molecular medicine reports
Zhang Z,Pu A,Yu M,Xiao W,Sun L,Cai Y,Yang H
45-0451-82 was used in Flow cytometry/Cell sorting to suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.
Fri Mar 01 00:00:00 EST 2019
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
45-0451 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer.
The Journal of experimental medicine
Raz Y,Cohen N,Shani O,Bell RE,Novitskiy SV,Abramovitz L,Levy C,Milyavsky M,Leider-Trejo L,Moses HL,Grisaru D,Erez N
45-0451-82 was used in Flow cytometry/Cell sorting to conclude that PDGFRα expression distinguishes two functionally unique CAF populations in breast tumors and metastases and may have important implications for patient stratification and precision therapeutics.
Mon Dec 03 00:00:00 EST 2018
Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development.
Frontiers in immunology
Pinto AI,Smith J,Kissack MR,Hogg KG,Green EA
45-0451 was used in Flow cytometry/Cell sorting to suggest that the thymus may be a principal autoimmune target in T1D and contributes to disease progression.
Tue Aug 20 00:00:00 EDT 2019
Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice.
PloS one
Xu SX,Leontyev D,Kaul R,Gray-Owen SD
45-0451 was used in Flow cytometry/Cell sorting to study HIV shedding during gonococcal co-infection and demonstrate that CD34+ stem cell-transplanted NSG mice represent an experimentally tractable animal model in which to do so.
Mon Feb 26 00:00:00 EST 2018
Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice.
PloS one
Arai S,Iwabuchi N,Takahashi S,Xiao JZ,Abe F,Hachimura S
45-0451 was used in Flow cytometry/Cell sorting to investigate the effects of orally administered heat-killed MCC1849 on IgA production in the intestine and on Tfh cell induction in vivo.
Wed Jan 02 00:00:00 EST 2019
Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions.
Communications biology
Rowley TF,Peters SJ,Aylott M,Griffin R,Davies NL,Healy LJ,Cutler RM,Eddleston A,Pither TL,Sopp JM,Zaccheo O,Fossati G,Cain K,Ventom AM,Hailu H,Ward EJ,Sherington J,Brennan FR,Fallah-Arani F,Humphreys DP
45-0451 was used in Flow cytometry/Cell sorting to engineer human Fc hexamers and explore their therapeutic and safety profiles.
Sat Jan 11 00:00:00 EST 2020
CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload.
JACC. Basic to translational science
Patel B,Bansal SS,Ismahil MA,Hamid T,Rokosh G,Mack M,Prabhu SD
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that monocyte-derived C-C chemokine receptor 2 macrophages infiltrate the heart early during pressure overload in mice and blocking this response alleviates cardiac fibrosis..
Sun Apr 01 00:00:00 EDT 2018
CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages.
Cell discovery
Li D,Hu M,Liu Y,Ye P,Du P,Li CS,Cheng L,Liu P,Jiang J,Su L,Wang S,Zheng P,Liu Y
45-0451-82 was used in Flow cytometry/Cell sorting to show that targeted mutation of Cd24 dramatically increased HCC burden while reducing intrahepatic macrophages and DEN-induced hepatocyte apoptosis.
Thu Oct 01 00:00:00 EDT 2020
Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.
Frontiers in immunology
Gubernatorova EO,Gorshkova EA,Namakanova OA,Zvartsev RV,Hidalgo J,Drutskaya MS,Tumanov AV,Nedospasov SA
45-0451 was used in Flow cytometry/Cell sorting to indicate that IL-6 plays a pathogenic role in the HDM-induced asthma model and that lung macrophages and dendritic cells are the predominant sources of pathogenic IL-6 but contribute differently to the disease.
Wed Oct 02 00:00:00 EDT 2019
Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages.
Immunity
Goudot C,Coillard A,Villani AC,Gueguen P,Cros A,Sarkizova S,Tang-Huau TL,Bohec M,Baulande S,Hacohen N,Amigorena S,Segura E
45-0451 was used in Flow cytometry/Cell sorting to elucidate the role of the aryl hydrocarbon receptor as a molecular switch for monocyte fate specification in response to micro-environmental factors.
Tue Sep 19 00:00:00 EDT 2017
Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Vijay R,Fehr AR,Janowski AM,Athmer J,Wheeler DL,Grunewald M,Sompallae R,Kurup SP,Meyerholz DK,Sutterwala FS,Narumiya S,Perlman S
45-0451 was used in Flow cytometry/Cell sorting to study the role of Prostaglandin D2 signalling in optimal microglia/macrophage activation and interferon expression after infection with a neurotropic coronavirus.
Mon Jul 03 00:00:00 EDT 2017
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
45-0451 was used in Flow cytometry/Cell sorting to assess the translational potential of soluble TNF inhibitors to modulate brain immune cell infiltration, dampen neuroinflammation and prevent or delay neuronal dysfunction in Alzheimer's disease.
Thu Jun 01 00:00:00 EDT 2017
Herpes Simplex Virus Glycoprotein D Targets a Specific Dendritic Cell Subset and Improves the Performance of Vaccines to Human Papillomavirus-Associated Tumors.
Molecular cancer therapeutics
Porchia BFMM,Moreno ACR,Ramos RN,Diniz MO,de Andrade LHTM,Rosa DS,Barbuto JAM,Boscardin SB,Ferreira LCS
45-0451 was used in Flow cytometry/Cell sorting to characterise a therapeutic antitumour vaccine based on the genetic fusion of the Herpes simplex virus-1 glycoprotein D with the E7 oncoprotein from human papillomavirus-16.
Fri Sep 01 00:00:00 EDT 2017
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.
The American journal of pathology
McClendon J,Jansing NL,Redente EF,Gandjeva A,Ito Y,Colgan SP,Ahmad A,Riches DWH,Chapman HA,Mason RJ,Tuder RM,Zemans RL
45-0451 was used in Flow cytometry/Cell sorting to study whether hypoxia-inducible factor 1α promotes proliferation and spreading of alveolar type II cells during repair after lung injury.
Tue Aug 01 00:00:00 EDT 2017
AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality.
Journal of immunology (Baltimore, Md. : 1950)
Zhang H,Luo J,Alcorn JF,Chen K,Fan S,Pilewski J,Liu A,Chen W,Kolls JK,Wang J
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that influenza infection activates the AIM2 inflammasome, which plays a critical role in IAV-induced lung injury and mortality.
Thu Jun 01 00:00:00 EDT 2017
Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition.
Genes & nutrition
Roselli M,Devirgiliis C,Zinno P,Guantario B,Finamore A,Rami R,Perozzi G
45-0451 was used in Flow cytometry/Cell sorting to study, using a mouse model, the effects of supplementary dietary microbes on obesity-associated inflammation and gut microbiota composition.
Thu Oct 01 00:00:00 EDT 2020
Notch4 signaling pathway in a Kawasaki disease mouse model induced by Lactobacillus casei cell wall extract.
Experimental and therapeutic medicine
Gao L,Fu S,Wang W,Xie C,Zhang Y,Gong F
45-0451 was used in Flow cytometry/Cell sorting to show the Notch4 signalling pathway participates in coronary artery lesions in Kawasaki disease animal models induced by Lactobacillus casei cell wall extract.
Thu Jun 01 00:00:00 EDT 2017
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages.
Oncoimmunology
Kersten K,Coffelt SB,Hoogstraat M,Verstegen NJM,Vrijland K,Ciampricotti M,Doornebal CW,Hau CS,Wellenstein MD,Salvagno C,Doshi P,Lips EH,Wessels LFA,de Visser KE
45-0451 was used in Flow cytometry/Cell sorting to demonstrate mammary tumor-derived CCL2 can facilitate the breast cancer-induced pro-metastatic systemic inflammatory gamma delta T cell-IL17–neutrophil axis.
Sat Jan 29 00:00:00 EST 2022
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Oncoimmunology
Ehx G,Fransolet G,de Leval L,D'Hondt S,Lucas S,Hannon M,Delens L,Dubois S,Drion P,Beguin Y,Humblet-Baron S,Baron F
45-0451 was used in Flow cytometry/Cell sorting to investigate the impact of 5-azacytidine on xenogeneic graft-vs.-host disease and graft-vs.-leukaemia effects in a humanised murine model of transplantation.
Tue Jan 12 00:00:00 EST 2021
Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.
Nature communications
Liang H,Deng L,Hou Y,Meng X,Huang X,Rao E,Zheng W,Mauceri H,Mack M,Xu M,Fu YX,Weichselbaum RR
45-0451 was used in Flow cytometry/Cell sorting to demonstrate how extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING.
Thu Nov 23 00:00:00 EST 2017
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.
PloS one
Patel B,Ismahil MA,Hamid T,Bansal SS,Prabhu SD
45-0451 was used in Flow cytometry/Cell sorting to assess for alterations in MPs.
Thu Aug 10 00:00:00 EDT 2017
Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice.
Oncotarget
Kantari-Mimoun C,Krzywinska E,Castells M,Milien C,Klose R,Meinecke AK,Lemberger U,Mathivet T,Gojkovic M,Schrödter K,Österreicher C,Fandrey J,Rundqvist H,Stockmann C
45-0451 was used in Flow cytometry/Cell sorting to show that the resolution of fibrosis can be accelerated by deleting VHL, a negative regulator of HIFs and VEGF, specifically in myeloid cells in mice.
Tue Feb 28 00:00:00 EST 2017
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
45-0451 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which loss of HIF1α in natural killer cells inhibits tumour growth.
Fri Nov 17 00:00:00 EST 2017
Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.
Journal of hepatology
Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ
45-0451 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.
Fri Jan 01 00:00:00 EST 2016
IL-17C is required for lethal inflammation during systemic fungal infection.
Cellular & molecular immunology
Huang J,Meng S,Hong S,Lin X,Jin W,Dong C
45-0451 was used in Flow cytometry/Cell sorting to elucidate the function of the IL-17 family members in anti-fungal immunity.
Fri Jul 01 00:00:00 EDT 2016
Early life stress perturbs the maturation of microglia in the developing hippocampus.
Brain, behavior, and immunity
Delpech JC,Wei L,Hao J,Yu X,Madore C,Butovsky O,Kaffman A
45-0451 was used in Flow cytometry/Cell sorting to study the effect of early life stress on the maturation of microgila in the developing hippocampus, and to identify the key regulatory transcription factors involved in maturation.
Sat Oct 01 00:00:00 EDT 2016
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology
Srikakulapu P,Hu D,Yin C,Mohanta SK,Bontha SV,Peng L,Beer M,Weber C,McNamara CA,Grassia G,Maffia P,Manz RA,Habenicht AJ
45-0451 was used in Flow cytometry/Cell sorting to study how artery tertiary lymphoid organs can orchestrate B-cell responses in the diseased aorta.
Wed Jun 01 00:00:00 EDT 2016
Bone marrow contribution to synovial hyperplasia following joint surface injury.
Arthritis research & therapy
Sergijenko A,Roelofs AJ,Riemen AH,De Bari C
45-0451 was used in Flow cytometry/Cell sorting to determine the respective involvement of resident slow-cycling cells and infiltrating bone marrow-derived cells during joint surface injury-induced synovial hyperplasia.
Wed Jul 13 00:00:00 EDT 2016
Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures.
Journal of immunology (Baltimore, Md. : 1950)
Nayar S,Campos J,Chung MM,Navarro-Núñez L,Chachlani M,Steinthal N,Gardner DH,Rankin P,Cloake T,Caamaño JH,McGettrick HM,Watson SP,Luther S,Buckley CD,Barone F
45-0451 was used in Flow cytometry/Cell sorting to study the kinetics and dynamic changes occurring to the lymphatic vascular network during tertiary lymphoid structure (TLS) development, showing that expansion of the lymphatic vascular network is tightly regulated by the sequential expression of IL-7 and Lymphotoxin α1β2.
Thu Sep 01 00:00:00 EDT 2016
Macrophages form functional vascular mimicry channels in vivo.
Scientific reports
Barnett FH,Rosenfeld M,Wood M,Kiosses WB,Usui Y,Marchetti V,Aguilar E,Friedlander M
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that macrophages are capable of forming primitive, non-endothelial vessels in models of tumours and angiogenesis.
Fri Nov 11 00:00:00 EST 2016
Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury.
Nature communications
Saha S,Aranda E,Hayakawa Y,Bhanja P,Atay S,Brodin NP,Li J,Asfaha S,Liu L,Tailor Y,Zhang J,Godwin AK,Tome WA,Wang TC,Guha C,Pollard JW
45045182 was used in flow cytometry to report that macrophage-derived extra vesicle-packaged WNTs are essential for intestinal regenerative response after radiation
Thu Oct 13 00:00:00 EDT 2016
A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.
JCI insight
Srivastava N,Iyer S,Sudan R,Youngs C,Engelman RW,Howard KT,Russo CM,Chisholm JD,Kerr WG
45-0451 was used in Flow cytometry/Cell sorting to investigate how SHIPi represents an approach that permits control of obesity and diet-induced metabolic syndrome without apparent toxicity.
Thu Jul 21 00:00:00 EDT 2016
Streptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model.
Scientific reports
Bazett M,Bergeron ME,Haston CK
45-0451 was used in Flow cytometry/Cell sorting to reveal a potential intestinal microbiome influence on lung response in BALB/c Cftr(tm1UNC) mice.
Tue Jan 12 00:00:00 EST 2016
Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.
Scientific reports
Song ZH,Li ZY,Li DD,Fang WN,Liu HY,Yang DD,Meng CY,Yang Y,Peng JP
45-0451 was used in Flow cytometry/Cell sorting to identify a new mechanism by which seminal plasma could influence inflammation in the uterus through the γδ T/IL-17 pathway.
Mon Apr 25 00:00:00 EDT 2016
Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.
Nature medicine
Chimen M,McGettrick HM,Apta B,Kuravi SJ,Yates CM,Kennedy A,Odedra A,Alassiri M,Harrison M,Martin A,Barone F,Nayar S,Hitchcock JR,Cunningham AF,Raza K,Filer A,Copland DA,Dick AD,Robinson J,Kalia N,Walker LSK,Buckley CD,Nash GB,Narendran P,Rainger GE
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that exogenous PEPITEM reduces T cell recruitment into inflamed tissues in multiple animal models of autoimmune, inflammatory diseases.
Fri May 01 00:00:00 EDT 2015
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Nature genetics
Hobbs RP,DePianto DJ,Jacob JT,Han MC,Chung BM,Batazzi AS,Poll BG,Guo Y,Han J,Ong S,Zheng W,Taube JM,Čiháková D,Wan F,Coulombe PA
45-0451 was used in Flow cytometry/Cell sorting to provide new insight into keratin intermediate filament and Aire function, as well as a molecular basis for the K17-dependent amplification of inflammatory and immune responses in diseased epithelia.
Sat Aug 01 00:00:00 EDT 2015
Nonvenous origin of dermal lymphatic vasculature.
Circulation research
Martinez-Corral I,Ulvmar MH,Stanczuk L,Tatin F,Kizhatil K,John SW,Alitalo K,Ortega S,Makinen T
45-0451 was used in Flow cytometry/Cell sorting to investigate the origin of murine lymphatic vasculature, showing a significant contribution from nonvenous cells.
Fri May 08 00:00:00 EDT 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
45-0451 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa.
American journal of physiology. Lung cellular and molecular physiology
Patankar YR,Mabaera R,Berwin B
45-0451 was used in Flow cytometry/Cell sorting to demonstrate the physiological contribution of neutrophils as a source of IL-1β in response to P. aeruginosa infection.
Thu Oct 15 00:00:00 EDT 2015
Generation of embryonic stem cells from mouse adipose-tissue derived cells via somatic cell nuclear transfer.
Cell cycle (Georgetown, Tex.)
Qin Y,Qin J,Zhou C,Li J,Gao WQ
45-0451 was used in Flow cytometry/Cell sorting to demonstrates that ESCs can be generated from the adipose tissue by somatic cell nuclear transfer (SCNT) and suggests that ADCs can be a new donor-cell type for potential therapeutic cloning.
Tue Jan 26 00:00:00 EST 2016
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.
The Journal of biological chemistry
Chen R,Zhang K,Chen H,Zhao X,Wang J,Li L,Cong Y,Ju Z,Xu D,Williams BR,Jia J,Liu JP
45-0451 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which TERC and TERT participate in lung diseases.
Fri Dec 25 00:00:00 EST 2015
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.
Nature immunology
Lee M,Kiefel H,LaJevic MD,Macauley MS,Kawashima H,O'Hara E,Pan J,Paulson JC,Butcher EC
45-0451 was used in Flow cytometry/Cell sorting to investigate the molecular signatures that distinguish HEVs from capillary endothelium, revealing control mechanisms for lymphocyte homing.
Wed Oct 01 00:00:00 EDT 2014
CLEC-2 is required for development and maintenance of lymph nodes.
Blood
Bénézech C,Nayar S,Finney BA,Withers DR,Lowe K,Desanti GE,Marriott CL,Watson SP,Caamaño JH,Buckley CD,Barone F
45-0451 was used in Flow cytometry/Cell sorting to investigate the role that CLEC-2 plays in the development and maintenance of lymph nodes.
Thu May 15 00:00:00 EDT 2014
Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis.
Development (Cambridge, England)
Reeh KA,Cardenas KT,Bain VE,Liu Z,Laurent M,Manley NR,Richie ER
45-0451 was used in Flow cytometry/Cell sorting to test the hypothesis that Tbx1 negatively regulates thymic epithelial cell growth and differentiation.
Fri Aug 01 00:00:00 EDT 2014
The use of anchored agonists of phagocytic receptors for cancer immunotherapy: B16-F10 murine melanoma model.
PloS one
Janotová T,Jalovecká M,Auerová M,Švecová I,Bruzlová P,Maierová V,Kumžáková Z,Cunátová Š,Vlčková Z,Caisová V,Rozsypalová P,Lukáčová K,Vácová N,Wachtlová M,Salát J,Lieskovská J,Kopecký J,Ženka J
45-0451 was used in Flow cytometry/Cell sorting to assess the anti-tumour potential of fusing phagocytic receptor agonists to cancer cells.
Thu Sep 18 00:00:00 EDT 2014
Uterine natural killer cells severely decrease in number at gestation day 6 in mice.
Biology of reproduction
Takashima A,Ishikawa F,Kuwabara T,Tanaka Y,Kinoshita T,Ito M,Kakiuchi T
45-0451 was used in Flow cytometry/Cell sorting to study how uterine NK cells or their precursors migrate into the uterus, mature, and produce interferon-gamma to support pregnancy in mice.
Tue Oct 01 00:00:00 EDT 2013
Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.
Clinical & developmental immunology
Maes W,Verschuere T,Van Hoylandt A,Boon L,Van Gool S
45-0451 was used in Flow cytometry/Cell sorting to evaluate the local elimination of Tregs as a tool for augmentation of the antitumoural response.
Tue Dec 10 00:00:00 EST 2013
PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis.
Journal of the American Society of Nephrology : JASN
Ito H,Yan X,Nagata N,Aritake K,Katsumata Y,Matsuhashi T,Nakamura M,Hirai H,Urade Y,Asano K,Kubo M,Utsunomiya Y,Hosoya T,Fukuda K,Sano M
45-0451 was used in Flow cytometry/Cell sorting to explore the contribution of L-PGDS to the development of chronic kidney disease.
Thu Nov 01 00:00:00 EDT 2012
Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.
The Journal of biological chemistry
Badeaux AI,Yang Y,Cardenas K,Vemulapalli V,Chen K,Kusewitt D,Richie E,Li W,Bedford MT
45-0451 was used in Flow cytometry/Cell sorting to study how PHF20 is not required for maintaining the global H4K16 acetylation levels or locus specific histone acetylation but instead works downstream in transcriptional regulation of MOF target genes.
Mon Jan 02 00:00:00 EST 2012
IL-33 exacerbates acute kidney injury.
Journal of the American Society of Nephrology : JASN
Akcay A,Nguyen Q,He Z,Turkmen K,Won Lee D,Hernando AA,Altmann C,Toker A,Pacic A,Ljubanovic DG,Jani A,Faubel S,Edelstein CL
45-0451 was used in Flow cytometry/Cell sorting to demonstrate that IL-33 promotes acute kidney injury through CD4 T cell-mediated production of CXCL1.
Tue Nov 01 00:00:00 EDT 2011
Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.
Infection and immunity
Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T
45-0451 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.
Tue Mar 01 00:00:00 EST 2011
