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AIFM2 Polyclonal Antibody

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Antibody Testing Data (6)

AIFM2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

AIFM2 Antibody (20886-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver tissue slide using (Product # 20886-1-AP) (AIFM2/ FSP1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

AIFM2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20886-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,500

View 48 publications 48 publications

Immunohistochemistry (IHC)

View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AIFM2 Fusion Protein Ag13412 (1-373 aa encoded by BC023601)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGSQVSVES GALHVVIVGG GFGGIAAASQ LQALNVPFML VDMKDSFHHN VAALRASVET GFAKKTFISY SVTFKDNFRQ GLVVGIDLKN QMVLLQGGEA LPFSHLILAT GSTGPFPGKF NEVSSQQAAI QAYEDMVRQV QRSRFIVVVG GGSAGVEMAA EIKTEYPEKE VTLIHSQVAL ADKELLPSVR QEVKEILLRK GVQLLLSERV SNLEELPLNE YREYIKVQTD KGTEVATNLV ILCTGIKINS SAYRKAFESR LASSGALRVN EHLQVEGHSN VYAIGDCADV RTPKMAYLAG LHANIAVANI VNSVKQRPLQ AYKPGALTFL LSMGRNDGVG QISGFYVGRL MVRLTKSRDL FVSTSWKTMR QSPP (1-373 aa encoded by BC023601)

Target Information

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Xie L,Zhou C,Wu Y,Fu X,Zhang G,Han X,Xie S,Chen G,Xu H,Deng B,Liu B,Zhou Y,Li A

Thu Jun 01 00:00:00 EDT 2023

LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.

Laboratory investigation; a journal of technical methods and pathology

Yu R,Wu Y,He P,Bai Y,Zhang Y,Bian X,Sun G,Zhang B

Wed Feb 01 00:00:00 EST 2023

Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer.

Cellular and molecular gastroenterology and hepatology

Cheu JW,Lee D,Li Q,Goh CC,Bao MH,Yuen VW,Zhang MS,Yang C,Chan CY,Tse AP,Sit GF,Liu CX,Ng IO,Wong CM,Wong CC

Tue Jun 20 00:00:00 EDT 2023

Thorium(IV) triggers ferroptosis through disrupting iron homeostasis and heme metabolism in the liver following oral ingestion.

Journal of hazardous materials

Ma M,Wang R,Xu M

Thu Jun 15 00:00:00 EDT 2023

Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression.

Cell research

Qiu S,Zhong X,Meng X,Li S,Qian X,Lu H,Cai J,Zhang Y,Wang M,Ye Z,Zhang H,Gao P

Sat Apr 01 00:00:00 EDT 2023

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis.

Life science alliance

Wang TX,Duan KL,Huang ZX,Xue ZA,Liang JY,Dang Y,Zhang A,Xiong Y,Ding C,Guan KL,Yuan HX

Sun Jan 01 00:00:00 EST 2023

Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Journal of ethnopharmacology

Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL

Sat Oct 28 00:00:00 EDT 2023

Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Journal of ethnopharmacology

Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL

Sat Oct 28 00:00:00 EDT 2023

Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Journal of ethnopharmacology

Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL

Sat Oct 28 00:00:00 EDT 2023

Bone Marrow-Derived Mesenchymal Stem Cells Transplantation Attenuates Renal Fibrosis Following Acute Kidney Injury in Rats by Diminishing Pericyte-Myofibroblast Transition and Extracellular Matrix Augment.

Transplantation proceedings

Wang H,Li M,Fei L,Xie C,Ding L,Zhu C,Zeng F,Liu N

Fri Feb 24 00:00:00 EST 2023

Loss of Lactate/Proton Monocarboxylate Transporter 4 Induces Ferroptosis via the AMPK/ACC Pathway and Inhibition of Autophagy on Human Bladder Cancer 5637 Cell Line.

Journal of oncology

Dong S,Zheng L,Jiang T

Thu Feb 02 00:00:00 EST 2023

Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Bu C,Hu S,Yu J,Li N,Gu J,Sheng Z,Yan Z,Bu X

Mon May 01 00:00:00 EDT 2023

Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Bu C,Hu S,Yu J,Li N,Gu J,Sheng Z,Yan Z,Bu X

Mon May 01 00:00:00 EDT 2023

Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.

Archives of biochemistry and biophysics

Du Q,Wu X,Ma K,Liu W,Liu P,Hayashi T,Mizuno K,Hattori S,Fujisaki H,Ikejima T

Sat Jul 15 00:00:00 EDT 2023

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.

Cell death & disease

Cheng L,He Q,Liu B,Chen L,Lv F,Li X,Li Y,Liu C,Song Y,Xing Y

Tue Jan 31 00:00:00 EST 2023

SIRT6 drives sensitivity to ferroptosis in anaplastic thyroid cancer through NCOA4-dependent autophagy.

American journal of cancer research

Yang Z,Huang R,Wang Y,Guan Q,Li D,Wu Y,Liao T,Wang Y,Xiang J

Sat Mar 11 00:00:00 EST 2023

Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.

Toxicology and applied pharmacology

He X,Liang SM,Wang HQ,Tao L,Sun FF,Wang Y,Zhang C,Huang YC,Xu DX,Chen X

Sat Apr 15 00:00:00 EDT 2023

Tryptophan Metabolism Acts as a New Anti-Ferroptotic Pathway to Mediate Tumor Growth.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu D,Liang CH,Huang B,Zhuang X,Cui W,Yang L,Yang Y,Zhang Y,Fu X,Zhang X,Du L,Gu W,Wang X,Yin C,Chai R,Chu B

Wed Feb 01 00:00:00 EST 2023

Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells.

iScience

He J,Abikoye AM,McLaughlin BP,Middleton RS,Sheldon R,Jones RG,Schafer ZT

Fri Jun 16 00:00:00 EDT 2023

Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.

Cell chemical biology

Armenta DA,Laqtom NN,Alchemy G,Dong W,Morrow D,Poltorack CD,Nathanson DA,Abu-Remalieh M,Dixon SJ

Thu Nov 17 00:00:00 EST 2022

Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhou M,Dong J,Huang J,Ye W,Zheng Z,Huang K,Pan Y,Cen J,Liang Y,Shu G,Ye S,Lu X,Zhang J

Mon Aug 01 00:00:00 EDT 2022

Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.

Antioxidants (Basel, Switzerland)

Wang S,Zheng Y,Jin S,Fu Y,Liu Y

Sun Dec 11 00:00:00 EST 2022

Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.

Antioxidants (Basel, Switzerland)

Wang S,Zheng Y,Jin S,Fu Y,Liu Y

Sun Dec 11 00:00:00 EST 2022

Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.

Antioxidants (Basel, Switzerland)

Wang S,Zheng Y,Jin S,Fu Y,Liu Y

Sun Dec 11 00:00:00 EST 2022

Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.

Antioxidants (Basel, Switzerland)

Wang S,Zheng Y,Jin S,Fu Y,Liu Y

Sun Dec 11 00:00:00 EST 2022

Kv7.4 channel is a key regulator of vascular inflammation and remodeling in neointimal hyperplasia and abdominal aortic aneurysms.

Free radical biology & medicine

Fan XZ,Wang YY,Cui ZY,Cheng ZH,Zhang HL,Gamper N,Zhang F,Han M

Sat Jan 01 00:00:00 EST 2022

LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway.

Molecular medicine reports

Hu JX,Zheng ZQ,Kang T,Qian W,Huang SH,Li BG

Fri Jul 01 00:00:00 EDT 2022

RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m⁶A-dependent manner.

Cell death & disease

Sun S,Gao T,Pang B,Su X,Guo C,Zhang R,Pang Q

Fri Jan 21 00:00:00 EST 2022

Tongxinluo prevents chronic obstructive pulmonary disease complicated with atherosclerosis by inhibiting ferroptosis and protecting against pulmonary microvascular barrier dysfunction.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Wang Y,Kuang X,Yin Y,Han N,Chang L,Wang H,Hou Y,Li H,Li Z,Liu Y,Hao Y,Wei Y,Wang X,Jia Z

Sat Jan 01 00:00:00 EST 2022

HOIP modulates the stability of GPx4 by linear ubiquitination.

Proceedings of the National Academy of Sciences of the United States of America

Dong K,Wei R,Jin T,Zhang M,Shen J,Xiang H,Shan B,Yuan J,Li Y

Tue Nov 01 00:00:00 EDT 2022

Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.

Nature communications

Hu Y,Wang Q,Yu J,Zhou Q,Deng Y,Liu J,Zhang L,Xu Y,Xiong W,Wang Y

Mon Jan 10 00:00:00 EST 2022

Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.

Nature communications

Hu Y,Wang Q,Yu J,Zhou Q,Deng Y,Liu J,Zhang L,Xu Y,Xiong W,Wang Y

Mon Jan 10 00:00:00 EST 2022

Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.

Frontiers in oncology

Sun C,Liu P,Pei L,Zhao M,Huang Y

Fri Apr 15 00:00:00 EDT 2022

Propofol Inhibits Proliferation and Augments the Anti-Tumor Effect of Doxorubicin and Paclitaxel Partly Through Promoting Ferroptosis in Triple-Negative Breast Cancer Cells.

Frontiers in oncology

Sun C,Liu P,Pei L,Zhao M,Huang Y

Fri Apr 15 00:00:00 EDT 2022

LncRNA HEPFAL accelerates ferroptosis in hepatocellular carcinoma by regulating SLC7A11 ubiquitination.

Cell death & disease

Zhang B,Bao W,Zhang S,Chen B,Zhou X,Zhao J,Shi Z,Zhang T,Chen Z,Wang L,Zheng X,Chen G,Wang Y

Thu Aug 25 00:00:00 EDT 2022

Abrogation of ARF6 in promoting erastin-induced ferroptosis and mitigating capecitabine resistance in gastric cancer cells.

Journal of gastrointestinal oncology

Geng D,Wu H

Wed Jun 01 00:00:00 EDT 2022

Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Huang S,Wang Y,Xie S,Lai Y,Mo C,Zeng T,Kuang S,Zhou C,Zeng Z,Chen Y,Huang S,Gao L,Lv Z

Fri Jul 01 00:00:00 EDT 2022

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

Nature communications

Koppula P,Lei G,Zhang Y,Yan Y,Mao C,Kondiparthi L,Shi J,Liu X,Horbath A,Das M,Li W,Poyurovsky MV,Olszewski K,Gan B

Fri Apr 22 00:00:00 EDT 2022

Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage.

Oxidative medicine and cellular longevity

Wang B,Zhang X,Zhong J,Wang S,Zhang C,Li M,Hu Q,Wang S,Chen L,Chen W,Ge H,Feng H

Tue Aug 16 00:00:00 EDT 2022

Dexpramipexole Attenuates White Matter Injury to Facilitate Locomotion and Motor Coordination Recovery via Reducing Ferroptosis after Intracerebral Hemorrhage.

Oxidative medicine and cellular longevity

Wang B,Zhang X,Zhong J,Wang S,Zhang C,Li M,Hu Q,Wang S,Chen L,Chen W,Ge H,Feng H

Tue Aug 16 00:00:00 EDT 2022

The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.

Oncogene

Zhang Y,Xu Z,Wen W,Liu Z,Zhang C,Li M,Hu F,Wei S,Bae S,Zhou J,Liu R,Wang L

Wed Jun 01 00:00:00 EDT 2022

The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progression.

Oncogene

Zhang Y,Xu Z,Wen W,Liu Z,Zhang C,Li M,Hu F,Wei S,Bae S,Zhou J,Liu R,Wang L

Wed Jun 01 00:00:00 EDT 2022

Farrerol alleviates collagenase-induced tendinopathy by inhibiting ferroptosis in rats.

Journal of cellular and molecular medicine

Wu Y,Qian J,Li K,Li W,Yin W,Jiang H

Wed Jun 01 00:00:00 EDT 2022

Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage.

Oxidative medicine and cellular longevity

Yuan B,Zhao XD,Shen JD,Chen SJ,Huang HY,Zhou XM,Han YL,Zhou LJ,Lu XJ,Wu Q

Thu Jul 21 00:00:00 EDT 2022

NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.

Biochimica et biophysica acta. Molecular basis of disease

Feng Z,Qin Y,Huo F,Jian Z,Li X,Geng J,Li Y,Wu J

Sat Jan 01 00:00:00 EST 2022

Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents.

European journal of medicinal chemistry

Fang Y,Tan Q,Zhou H,Gu Q,Xu J

Sat Mar 05 00:00:00 EST 2022

CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis.

Signal transduction and targeted therapy

Wu J,Chen L,Qin C,Huo F,Liang X,Yang X,Zhang K,Lin P,Liu J,Feng Z,Zhou J,Pei Z,Wang Y,Sun XX,Wang K,Geng J,Zheng Z,Fu X,Liu M,Wang Q,Zhang Z,Bian H,Zhu P,Chen ZN

Fri Nov 25 00:00:00 EST 2022

Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro.

Frontiers in pharmacology

Zhao MY,Liu P,Sun C,Pei LJ,Huang YG

Sat Jul 16 00:00:00 EDT 2022

Propofol Augments Paclitaxel-Induced Cervical Cancer Cell Ferroptosis In Vitro.

Frontiers in pharmacology

Zhao MY,Liu P,Sun C,Pei LJ,Huang YG

Sat Jul 16 00:00:00 EDT 2022

SHARPIN promotes cell proliferation of cholangiocarcinoma and inhibits ferroptosis via p53/SLC7A11/GPX4 signaling.

Cancer science

Zeng C,Lin J,Zhang K,Ou H,Shen K,Liu Q,Wei Z,Dong X,Zeng X,Zeng L,Wang W,Yao J

Tue Nov 01 00:00:00 EDT 2022

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.

Cellular and molecular gastroenterology and hepatology

Huang S,Wang Y,Xie S,Lai Y,Mo C,Zeng T,Kuang S,Deng G,Zhou C,Chen Y,Huang S,Gao L,Lv Z

Thu May 19 00:00:00 EDT 2022

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.

Nature cancer

Zhang T,Sun L,Hao Y,Suo C,Shen S,Wei H,Ma W,Zhang P,Wang T,Gu X,Li ST,Chen Z,Yan R,Zhang Y,Cai Y,Zhou R,Jia W,Huang F,Gao P,Zhang H

Sat Jan 01 00:00:00 EST 2022

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.

Cell death & disease

Jo A,Bae JH,Yoon YJ,Chung TH,Lee EW,Kim YH,Joh HM,Chung JW

Mon Mar 07 00:00:00 EST 2022

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.

Cell death & disease

Jo A,Bae JH,Yoon YJ,Chung TH,Lee EW,Kim YH,Joh HM,Chung JW

Mon Mar 07 00:00:00 EST 2022

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.

Cell death & disease

Jo A,Bae JH,Yoon YJ,Chung TH,Lee EW,Kim YH,Joh HM,Chung JW

Mon Mar 07 00:00:00 EST 2022

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells.

Cell death & disease

Jo A,Bae JH,Yoon YJ,Chung TH,Lee EW,Kim YH,Joh HM,Chung JW

Mon Mar 07 00:00:00 EST 2022

Cadmium attenuates testosterone synthesis by promoting ferroptosis and blocking autophagosome-lysosome fusion.

Free radical biology & medicine

Zeng L,Zhou J,Wang X,Zhang Y,Wang M,Su P

Sat Nov 20 00:00:00 EST 2021

Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.

Biochimica et biophysica acta. Molecular basis of disease

Cheng H,Feng D,Li X,Gao L,Tang S,Liu W,Wu X,Yue S,Li C,Luo Z

Wed Dec 01 00:00:00 EST 2021

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.

Oxidative medicine and cellular longevity

Shao Y,Jia H,Li S,Huang L,Aikemu B,Yang G,Zhang S,Sun J,Zheng M

Thu Feb 17 00:00:00 EST 2022

Comprehensive Analysis of Ferroptosis-Related Markers for the Clinical and Biological Value in Gastric Cancer.

Oxidative medicine and cellular longevity

Shao Y,Jia H,Li S,Huang L,Aikemu B,Yang G,Zhang S,Sun J,Zheng M

Thu Feb 17 00:00:00 EST 2022

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects.

Cell metabolism

Dierge E,Debock E,Guilbaud C,Corbet C,Mignolet E,Mignard L,Bastien E,Dessy C,Larondelle Y,Feron O

Tue Aug 03 00:00:00 EDT 2021

A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis.

Nature communications

Yao F,Deng Y,Zhao Y,Mei Y,Zhang Y,Liu X,Martinez C,Su X,Rosato RR,Teng H,Hang Q,Yap S,Chen D,Wang Y,Chen MM,Zhang M,Liang H,Xie D,Chen X,Zhu H,Chang JC,You MJ,Sun Y,Gan B,Ma L

Fri Dec 17 00:00:00 EST 2021

DHA exhibits synergistic therapeutic efficacy with cisplatin to induce ferroptosis in pancreatic ductal adenocarcinoma via modulation of iron metabolism.

Cell death & disease

Du J,Wang X,Li Y,Ren X,Zhou Y,Hu W,Zhou C,Jing Q,Yang C,Wang L,Li H,Fang L,Zhou Y,Tong X,Wang Y

Thu Jul 15 00:00:00 EDT 2021

A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.

Bioorganic chemistry

Tan Q,Fang Y,Peng X,Zhou H,Xu J,Gu Q

Fri Oct 01 00:00:00 EDT 2021

Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.

Frontiers in cell and developmental biology

Huang S,Shao T,Liu H,Li T,Gui X,Zhao Q

Sat Feb 19 00:00:00 EST 2022

Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.

British journal of pharmacology

Li D,Liu B,Fan Y,Liu M,Han B,Meng Y,Xu X,Song Z,Liu X,Hao Q,Duan X,Nakai A,Chang Y,Cao P,Tan K

Mon Mar 01 00:00:00 EST 2021

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.

Cell reports

Zhao Y,Li M,Yao X,Fei Y,Lin Z,Li Z,Cai K,Zhao Y,Luo Z

Tue Dec 08 00:00:00 EST 2020

Impact of Wortmannilactone F and G31P on Clonorchis Sinensis-infected mice.

International immunopharmacology

Qin Y,Zhang Z,Zheng L,Wu H,Dai X,Dong Y,Cui Y,Ren Y

Sat Aug 01 00:00:00 EDT 2020

Abrogation of ARF6 promotes RSL3-induced ferroptosis and mitigates gemcitabine resistance in pancreatic cancer cells.

American journal of cancer research

Ye Z,Hu Q,Zhuo Q,Zhu Y,Fan G,Liu M,Sun Q,Zhang Z,Liu W,Xu W,Ji S,Yu X,Xu X,Qin Y

Mon Nov 13 00:00:00 EST 2023

Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.

International journal of oral science

Xie M,Tang Q,Yu S,Sun J,Mei F,Zhao J,Chen L

Wed Sep 30 00:00:00 EDT 2020

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

Nature

Bersuker K,Hendricks JM,Li Z,Magtanong L,Ford B,Tang PH,Roberts MA,Tong B,Maimone TJ,Zoncu R,Bassik MC,Nomura DK,Dixon SJ,Olzmann JA

Fri Nov 01 00:00:00 EDT 2019

miR-200b-containing microvesicles attenuate experimental colitis associated intestinal fibrosis by inhibiting epithelial-mesenchymal transition.

Journal of gastroenterology and hepatology

Yang J,Zhou CZ,Zhu R,Fan H,Liu XX,Duan XY,Tang Q,Shou ZX,Zuo DM

Fri Dec 01 00:00:00 EST 2017

Bioinformatics

Protein Aliases: AMID; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated, 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; Ferroptosis suppressor protein 1; FSP1; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; RP11-367H5.2

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Gene Aliases: 5430437E11Rik; AIFM2; AMID; D730001I10Rik; PRG3

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UniProt ID: (Human) Q9BRQ8, (Mouse) Q8BUE4

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Entrez Gene ID: (Human) 84883, (Mouse) 71361

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Function(s)

DNA binding electron-transferring-flavoprotein dehydrogenase activity flavin adenine dinucleotide binding NADH dehydrogenase (ubiquinone) activity N-ethylmaleimide reductase activity oxidoreductase activity reduced coenzyme F420 dehydrogenase activity sulfur oxygenase reductase activity malolactic enzyme activity NADPH:sulfur oxidoreductase activity epoxyqueuosine reductase activity oxidoreductase metabolite interconversion enzyme

Process(es)

apoptotic mitochondrial changes regulation of apoptotic process positive regulation of apoptotic process oxidation-reduction process

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AIFM2 Polyclonal Antibody

AIFM2 Antibody (20886-1-AP) in IHC (P)

Product Details

20886-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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