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Invitrogen
AIM2 Monoclonal Antibody (10M2B3)
Advanced Verification
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 6
AIM2 Antibody (MA5-16259) in WB
Western Blot was performed using Anti-AIM2 Monoclonal Antibody (10M2B3) (Product # MA5-16259) and a 40 kDa band corresponding to Interferon-inducible protein AIM2 was observed across tested samples. Whole cell extracts (40 µg lysate) of Daudi (Lane 1), Raji (Lane 2), HCT 116 (Lane 3), SH-SY5Y (Lane 4) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # LC2001) by iBlot® 2 Dry Blotting System (Product # IB21001). The Blot was p... View More
Product Details
MA5-16259
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
10M2B3
Immunogen
Recombinant AIM2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2537776
Target Information
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Absent in melanoma 2; Interferon-inducible protein AIM2; RP11-520H16.3
Gene Aliases: AIM2; PYHIN4
UniProt ID: (Human) O14862
Entrez Gene ID: (Human) 9447
activation of innate immune response
positive regulation of defense response to virus by host
apoptotic process
inflammatory response
immune response
negative regulation of NF-kappaB transcription factor activity
positive regulation of protein oligomerization
positive regulation of interleukin-1 beta production
tumor necrosis factor-mediated signaling pathway
cellular response to interferon-beta
cellular response to drug
innate immune response
interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
positive regulation of NF-kappaB transcription factor activity
pyroptosis
positive regulation of cysteine-type endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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