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AIM2 Monoclonal Antibody (3E12A8)

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Antibody Testing Data (1)

FIGURE: 1 / 1

AIM2 Antibody (66902-1-IG) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 66902-1-Ig (AIM2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Product Details

66902-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rabbit, Rat

Published species

Not Applicable

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3E12A8

Immunogen

AIM2 Fusion Protein Ag14607

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.

The EMBO journal

Liu H,Fan H,He P,Zhuang H,Liu X,Chen M,Zhong W,Zhang Y,Zhen C,Li Y,Jiang H,Meng T,Xu Y,Zhao G,Feng D

Thu Dec 15 00:00:00 EST 2022

Prohibitin 1 regulates mtDNA release and downstream inflammatory responses.

The EMBO journal

Liu H,Fan H,He P,Zhuang H,Liu X,Chen M,Zhong W,Zhang Y,Zhen C,Li Y,Jiang H,Meng T,Xu Y,Zhao G,Feng D

Thu Dec 15 00:00:00 EST 2022

STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis.

Gut

Dawson RE,Deswaerte V,West AC,Tang K,West AJ,Balic JJ,Gearing LJ,Saad MI,Yu L,Wu Y,Bhathal PS,Kumar B,Chakrabarti JT,Zavros Y,Oshima H,Klinman DM,Oshima M,Tan P,Jenkins BJ

Mon Aug 01 00:00:00 EDT 2022

Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway.

The Science of the total environment

Zhou J,Zeng L,Zhang Y,Wang M,Li Y,Jia Y,Wu L,Su P

Tue Nov 15 00:00:00 EST 2022

PKIB involved in the metastasis and survival of osteosarcoma.

Frontiers in oncology

Wan R,Yang G,Liu Q,Fu X,Liu Z,Miao H,Liu H,Huang W

Sat Sep 10 00:00:00 EDT 2022

Increased susceptibility of irradiated mice to Aspergillus fumigatus infection via NLRP3/GSDMD pathway in pulmonary bronchial epithelia.

Cell communication and signaling : CCS

Wu DM,He M,Zhao YY,Deng SH,Liu T,Zhang T,Zhang F,Wang YY,Xu Y

Mon Jun 27 00:00:00 EDT 2022

Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy.

Theranostics

Liang Q,Wu J,Zhao X,Shen S,Zhu C,Liu T,Cui X,Chen L,Wei C,Cheng P,Cheng W,Wu A

Mon Feb 07 00:00:00 EST 2022

Bioinformatics

Protein Aliases: Absent in melanoma 2; Ifi-210; Interferon-inducible protein 210; Interferon-inducible protein AIM2; Interferon-inducible protein p210; RP11-520H16.3

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Gene Aliases: AIM2; Gm1313; Ifi210; PYHIN4

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UniProt ID: (Human) O14862, (Mouse) Q91VJ1

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Entrez Gene ID: (Human) 9447, (Rat) 304987, (Mouse) 383619

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Function(s)

double-stranded DNA binding protein binding identical protein binding molecular_function DNA binding DNA-binding transcription factor

Process(es)

activation of innate immune response positive regulation of defense response to virus by host apoptotic process inflammatory response immune response negative regulation of NF-kappaB transcription factor activity positive regulation of protein oligomerization positive regulation of interleukin-1 beta production tumor necrosis factor-mediated signaling pathway cellular response to interferon-beta cellular response to drug innate immune response interleukin-1 beta secretion positive regulation of interleukin-1 beta secretion positive regulation of NF-kappaB transcription factor activity pyroptosis positive regulation of cysteine-type endopeptidase activity biological_process immune system process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AIM2 Monoclonal Antibody (3E12A8)

AIM2 Antibody (66902-1-IG) in WB

Product Details

66902-1-IG

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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