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ALDH2 Polyclonal Antibody

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Antibody Testing Data (18)

ALDH2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 18

ALDH2 Antibody (15310-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed A549 cells using 15310-1-AP (ALDH2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ALDH2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ALDH2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15310-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 38 publications 38 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH2 Fusion Protein Ag7452 (165-517 aa encoded by BC002967)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GDFFSYTRH EPVGVCGQII PWNFPLLMQA WKLGPALATG NVVVMKVAEQ TPLTALYVAN LIKEAGFPPG VVNIVPGFGP TAGAAIASHE DVDKVAFTGS TEIGRVIQVA AGSSNLKRVT LELGGKSPNI IMSDADMDWA VEQAHFALFF NQGQCCCAGS RTFVQEDIYD EFVERSVARA KSRVVGNPFD SKTEQGPQVD ETQFKKILGY INTGKQEGAK LLCGGGIAAD RGYFIQPTVF GDVQDGMTIA KEEIFGPVMQ ILKFKTIEEV VGRANNSTYG LAAAVFTKDL DKANYLSQAL QAGTVWVNCY DVFGAQSPFG GYKMSGSGRE LGEYGLQAYT EVKTVTVKVP QKNS (165-517 aa encoded by B C002967)

Target Information

ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Gastroenterology report

Zhou H,Wan S,Luo Y,Liu H,Jiang J,Guo Y,Xiao J,Wu B

Tue Mar 07 00:00:00 EST 2023

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Gastroenterology report

Zhou H,Wan S,Luo Y,Liu H,Jiang J,Guo Y,Xiao J,Wu B

Tue Mar 07 00:00:00 EST 2023

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Gastroenterology report

Zhou H,Wan S,Luo Y,Liu H,Jiang J,Guo Y,Xiao J,Wu B

Tue Mar 07 00:00:00 EST 2023

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Gastroenterology report

Zhou H,Wan S,Luo Y,Liu H,Jiang J,Guo Y,Xiao J,Wu B

Tue Mar 07 00:00:00 EST 2023

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

The EMBO journal

Yao P,Zhang Z,Liu H,Jiang P,Li W,Du W

Mon Apr 17 00:00:00 EDT 2023

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

The EMBO journal

Yao P,Zhang Z,Liu H,Jiang P,Li W,Du W

Mon Apr 17 00:00:00 EDT 2023

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

The EMBO journal

Yao P,Zhang Z,Liu H,Jiang P,Li W,Du W

Mon Apr 17 00:00:00 EDT 2023

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

The EMBO journal

Yao P,Zhang Z,Liu H,Jiang P,Li W,Du W

Mon Apr 17 00:00:00 EDT 2023

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

The EMBO journal

Yao P,Zhang Z,Liu H,Jiang P,Li W,Du W

Mon Apr 17 00:00:00 EDT 2023

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

The EMBO journal

Yao P,Zhang Z,Liu H,Jiang P,Li W,Du W

Mon Apr 17 00:00:00 EDT 2023

Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.

Neurochemical research

Diao M,Xu J,Wang J,Zhang M,Wu C,Hu X,Zhu Y,Zhang M,Hu W

Fri Apr 01 00:00:00 EDT 2022

Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice.

Alcoholism, clinical and experimental research

Hu Q,Chen H,Shen C,Zhang B,Weng X,Sun X,Liu J,Dong Z,Hu K,Ge J,Sun A

Sun May 01 00:00:00 EDT 2022

Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.

Antioxidants (Basel, Switzerland)

Li DM,Wu YX,Hu ZQ,Wang TC,Zhang LL,Zhou Y,Tong X,Xu JY,Qin LQ

Sun Jul 31 00:00:00 EDT 2022

Effect of different types of muscle activity on the gene and protein expression of ALDH family members in C57BL/6J mouse skeletal muscle.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Jee E,Tamura Y,Kouzaki K,Kotani T,Nakazato K

Fri Jul 01 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

JCI insight

Li L,Zhong S,Li R,Liang N,Zhang L,Xia S,Xu X,Chen X,Chen S,Tao Y,Yin H

Fri Apr 08 00:00:00 EDT 2022

Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL.

Archives of biochemistry and biophysics

Li P,Chen Y,Ke X,Zhang R,Zuo L,Wang M,Chen Z,Luo X,Wang J

Wed Jun 15 00:00:00 EDT 2022

Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.

American journal of physiology. Regulatory, integrative and comparative physiology

Kasai A,Jee E,Tamura Y,Kouzaki K,Kotani T,Nakazato K

Wed Jun 01 00:00:00 EDT 2022

The Effects of Alda-1 Treatment on Renal and Intestinal Injuries After Cardiopulmonary Resuscitation in Pigs.

Frontiers in medicine

Yu Q,Gao J,Shao X,Lu W,Chen L,Jin L

Sat Jul 16 00:00:00 EDT 2022

SIRT3 inhibitor 3-TYP exacerbates thioacetamide-induced hepatic injury in mice.

Frontiers in physiology

Shi C,Jiao F,Wang Y,Chen Q,Wang L,Gong Z

Fri Aug 05 00:00:00 EDT 2022

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells.

Development (Cambridge, England)

Brunsdon H,Brombin A,Peterson S,Postlethwait JH,Patton EE

Sun May 15 00:00:00 EDT 2022

The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models.

Molecules (Basel, Switzerland)

Wu J,Miyasaka K,Yamada W,Takeda S,Shimizu N,Shimoda H

Tue Jan 18 00:00:00 EST 2022

Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols.

Toxicology and applied pharmacology

Zhu C,Gu H,Jin Y,Wurm D,Freidhof B,Lu Y,Chen QM

Sun May 01 00:00:00 EDT 2022

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.

Frontiers in pharmacology

Ji W,Wan T,Zhang F,Zhu X,Guo S,Mei X

Wed May 26 00:00:00 EDT 2021

ALDH2 is a prognostic biomarker and related with immune infiltrates in HCC.

American journal of cancer research

Yao S,Yin X,Chen T,Chen W,Zuo H,Bi Z,Zhang X,Jing Y,Pang L,Cheng H

Wed Dec 08 00:00:00 EST 2021

Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.

Blood

Mu A,Hira A,Niwa A,Osawa M,Yoshida K,Mori M,Okamoto Y,Inoue K,Kondo K,Kanemaki MT,Matsuda T,Ito E,Kojima S,Nakahata T,Ogawa S,Tanaka K,Matsuo K,Saito MK,Takata M

Thu Apr 15 00:00:00 EDT 2021

Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.

Molecular nutrition & food research

Li D,He Q,Yang H,Du Y,Yu K,Yang J,Tong X,Guo Y,Xu J,Qin L

Wed Sep 01 00:00:00 EDT 2021

Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.

Alcoholism, clinical and experimental research

Chao X,Wang S,Yang L,Ni HM,Ding WX

Fri Oct 01 00:00:00 EDT 2021

Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition.

Cancers

Foucault A,Ravalet N,Besombes J,Picou F,Gallay N,Babin L,Bourgeais J,Hamard S,Domenech J,Loyer P,Vallet N,Lejeune J,Gyan E,Béné MC,Vallette F,Olivier C,Hérault O

Sun Nov 14 00:00:00 EST 2021

Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang H,Xia Y,Wang F,Luo M,Yang K,Liang S,An S,Wu S,Yang C,Chen D,Xu M,Cai M,To KKW,Fu L

Sat May 01 00:00:00 EDT 2021

Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.

Cancer discovery

Yang Z,Wu XS,Wei Y,Polyanskaya SA,Iyer SV,Jung M,Lach FP,Adelman ER,Klingbeil O,Milazzo JP,Kramer M,Demerdash OE,Chang K,Goodwin S,Hodges E,McCombie WR,Figueroa ME,Smogorzewska A,Vakoc CR

Wed Sep 01 00:00:00 EDT 2021

Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.

Redox biology

Zhong S,Li L,Liang N,Zhang L,Xu X,Chen S,Yin H

Sat May 01 00:00:00 EDT 2021

Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.

Redox biology

Zhong S,Li L,Liang N,Zhang L,Xu X,Chen S,Yin H

Sat May 01 00:00:00 EDT 2021

Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.

Biochemical pharmacology

Liu YC,Wang HL,Huang YZ,Weng YH,Chen RS,Tsai WC,Yeh TH,Lu CS,Chen YL,Lin YW,Chen YJ,Hsu CC,Chiu CH,Chiu CC

Fri May 01 00:00:00 EDT 2020

Aldehyde dehydrogenase 2 protects against sympathetic excitation-induced cardiac fibrosis.

Biochemical and biophysical research communications

Yuan Q,Yang F,Dai S,Wang Z,Xu Y,Xu BC,Sun Y,Zheng B,Zhao Y,Wang W,Liu B,Wang J,Cui S,Cao S,Zhang R,Xue L,Wei S,Xue M,Xu T,Xu F,Chen Y

Thu Dec 17 00:00:00 EST 2020

Combination of podophyllotoxin and rutin modulate radiation-induced alterations of jejunal proteome in mice.

International journal of radiation biology

Bajaj S,Alam SI,Ahmad B,Farooqi H,Gupta ML

Wed Jul 01 00:00:00 EDT 2020

Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.

Molecular medicine reports

Liu Z,Ye S,Zhong X,Wang W,Lai CH,Yang W,Yue P,Luo J,Huang X,Zhong Z,Xiong Y,Fan X,Li L,Wang Y,Ye Q

Tue Sep 01 00:00:00 EDT 2020

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.

American journal of physiology. Regulatory, integrative and comparative physiology

Wakabayashi Y,Tamura Y,Kouzaki K,Kikuchi N,Hiranuma K,Menuki K,Tajima T,Yamanaka Y,Sakai A,Nakayama KI,Kawamoto T,Kitagawa K,Nakazato K

Wed Apr 01 00:00:00 EDT 2020

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Molecular cell

Dingler FA,Wang M,Mu A,Millington CL,Oberbeck N,Watcham S,Pontel LB,Kamimae-Lanning AN,Langevin F,Nadler C,Cordell RL,Monks PS,Yu R,Wilson NK,Hira A,Yoshida K,Mori M,Okamoto Y,Okuno Y,Muramatsu H,Shiraishi Y,Kobayashi M,Moriguchi T,Osumi T,Kato M,Miyano S,Ito E,Kojima S,Yabe H,Yabe M,Matsuo K,Ogawa S,Göttgens B,Hodskinson MRG,Takata M,Patel KJ

Thu Dec 17 00:00:00 EST 2020

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Molecular cell

Thu Dec 17 00:00:00 EST 2020

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Molecular cell

Thu Dec 17 00:00:00 EST 2020

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Molecular cell

Thu Dec 17 00:00:00 EST 2020

Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.

The Journal of clinical investigation