Proteintech

ARL13B Polyclonal Antibody

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Antibody Testing Data (20)

ARL13B Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 20

ARL13B Antibody (17711-1-AP) in ICC/IF

Immunofluorescent images of MDCK cells stained with ARL13B rabbit pAb (17711-1-AP) and acetylated tubulin mouse mAb (66200-1-Ig) at dilution of 1:50, further stained with Alexa Fluor 488-conjugated AffiniPure-Goat anti-Rabbit IgG (H+L) for 17711-1-AP, and Alexa Fluor 594-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) for 66200-1-Ig.

ARL13B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ARL13B Antibody in Immunohistochemistry (IHC)

ARL13B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17711-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 71 publications 71 publications

Immunohistochemistry (IHC)

View 33 publications 33 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:200

View 567 publications 567 publications

Flow Cytometry (Flow)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 12 publications 12 publications

Not applicable (N/A)

View 18 publications 18 publications

Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Chicken, Dog, Human, Mouse, Pig, Rat, Sheep, Xenopus, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARL13B Fusion Protein Ag12015 (1-321 aa encoded by BC094725)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody detects two specific bands at 60 kDa and 48 kDa. Arl13b is predicted to be a 48 kDa protein, and the 60 kDa band is likely to represent a modified form of Arl13b. ARL13B can be used to mark the cilia.

Immunogen sequence: MFSLMASCC GWFKRWREPV RLANKQDKEG ALGEADVIEC LSLEKLVNEH KCLCQIEPCS AISGYGKKID KSIKKGLYWL LHVIARDFDA LNERIQKETT EQRALEEQEK QERAERVRKL REERKQNEQE QAELDGTSGL AELDPEPTNP FQPIASVIIE NEGKLEREKK NQKMEKDSDG CHLKHKMEHE QIETQGQVNH NGQKNNEFGL VENYKEALTQ QLKNEDETDR PSLESANGKK KTKKLRMKRN HRVEPLNIDD CAPESPTPPP PPPPVGWGTP KVTRLPKLEP LGETHHNDFY RKPLPPLAVP QRPNSDAHDV IS (1-321 aa encoded by BC094725)

Target Information

This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt.

Cells

Sénicourt B,Cloutier G,Basora N,Fallah S,Laniel A,Lavoie C,Beaulieu JF

Fri Mar 31 00:00:00 EDT 2023

The developmental basis of fingerprint pattern formation and variation.

Cell

Glover JD,Sudderick ZR,Shih BB,Batho-Samblas C,Charlton L,Krause AL,Anderson C,Riddell J,Balic A,Li J,Klika V,Woolley TE,Gaffney EA,Corsinotti A,Anderson RA,Johnston LJ,Brown SJ,Wang S,Chen Y,Crichton ML,Headon DJ

Thu Mar 02 00:00:00 EST 2023

Impairment of Connexin 43 may initiate cilia decline in syringomyelia.

Experimental neurology

Wang X,Jiang C,Lu C,Ma L,Feng Y,Cui S,Li Q,Li K,Wang X,Jian F

Sat Jul 01 00:00:00 EDT 2023

PDGF-AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia.

Journal of cellular biochemistry

Tsai YC,Kuo TN,Chao YY,Lee PR,Lin RC,Xiao XY,Huang BM,Wang CY

Sun Jan 01 00:00:00 EST 2023

Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence.

The Journal of biological chemistry

Mahajan D,Madugula V,Lu L

Mon May 01 00:00:00 EDT 2023

Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif containing ciliary targeting sequence.

The Journal of biological chemistry

Mahajan D,Madugula V,Lu L

Mon May 01 00:00:00 EDT 2023

Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective intraflagellar transport.

Journal of cell science

Hiyamizu S,Qiu H,Vuolo L,Stevenson NL,Shak C,Heesom KJ,Hamada Y,Tsurumi Y,Chiba S,Katoh Y,Stephens DJ,Nakayama K

Wed Mar 01 00:00:00 EST 2023

Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition.

Communications biology

Portal C,Lin Y,Rastogi V,Peterson C,Yiu SC,Foster JW,Wilkerson A,Butovich IA,Iomini C

Fri Mar 17 00:00:00 EDT 2023

MRCKα/β positively regulates Gli protein activity.

Cellular signalling

Baran B,Kosieradzka K,Skarzynska W,Niewiadomski P

Sat Jul 01 00:00:00 EDT 2023

Human LUHMES and NES cells as models for studying primary cilia in neurons.

Methods in cell biology

Coschiera A,Watts ME,Kere J,Tammimies K,Swoboda P

Fri May 12 00:00:00 EDT 2023

Kif6 regulates cilia motility and polarity in brain ependymal cells.

bioRxiv : the preprint server for biology

Takagishi M,Yue Y,Gray RS,Verhey KJ,Wallingford JB

Thu Feb 16 00:00:00 EST 2023

CEP164-GLI2 association ensures the hedgehog signaling in pancreatic cancer cells.

Biochemical and biophysical research communications

Fushimi T,Kobayashi T,Itoh H

Sun Jul 23 00:00:00 EDT 2023

Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation.

Development (Cambridge, England)

Elliott KH,Balchand SK,Bonatto Paese CL,Chang CF,Yang Y,Brown KM,Rasicci DT,He H,Thorner K,Chaturvedi P,Murray SA,Chen J,Porollo A,Peterson KA,Brugmann SA

Sat Apr 15 00:00:00 EDT 2023

A stress-induced cilium-to-PML-NB route drives senescence initiation.

Nature communications

Ma X,Zhang Y,Zhang Y,Zhang X,Huang Y,He K,Chen C,Hao J,Zhao D,LeBrasseur NK,Kirkland JL,Chini EN,Wei Q,Ling K,Hu J

Mon Apr 03 00:00:00 EDT 2023

A stress-induced cilium-to-PML-NB route drives senescence initiation.

Nature communications

Ma X,Zhang Y,Zhang Y,Zhang X,Huang Y,He K,Chen C,Hao J,Zhao D,LeBrasseur NK,Kirkland JL,Chini EN,Wei Q,Ling K,Hu J

Mon Apr 03 00:00:00 EDT 2023

LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.

Cell and tissue research

Bunatyan L,Margineanu A,Boutin C,Montcouquiol M,Bachmann S,Ilsø Christensen E,Willnow TE,Christ A

Mon May 01 00:00:00 EDT 2023

Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts.

Tissue & cell

Lin T,Sun Y

Thu Jun 01 00:00:00 EDT 2023

Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts.

Tissue & cell

Lin T,Sun Y

Thu Jun 01 00:00:00 EDT 2023

Scanning electron microscopy of human islet cilia.

bioRxiv : the preprint server for biology

Polino AJ,Sviben S,Melena I,Piston DW,Hughes J

Wed Feb 15 00:00:00 EST 2023

Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling.

Developmental cell

Feng X,Wang AH,Juan AH,Ko KD,Jiang K,Riparini G,Ciuffoli V,Kaba A,Lopez C,Naz F,Jarnik M,Aliberti E,Hu S,Segalés J,Khateb M,Acevedo-Luna N,Randazzo D,Cheung TH,Muñoz-Cánoves P,Dell'Orso S,Sartorelli V

Mon Jun 19 00:00:00 EDT 2023

Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse.

Developmental biology

Van Sciver RE,Long AB,Katz HG,Gigante ED,Caspary T

Tue Aug 01 00:00:00 EDT 2023

Atp7b-dependent choroid plexus dysfunction causes transient copper deficit and metabolic changes in the developing mouse brain.

PLoS genetics

Washington-Hughes CL,Roy S,Seneviratne HK,Karuppagounder SS,Morel Y,Jones JW,Zak A,Xiao T,Boronina TN,Cole RN,Bumpus NN,Chang CJ,Dawson TM,Lutsenko S

Sun Jan 01 00:00:00 EST 2023

Evaluation of Epithelial-Mesenchymal Transition Markers in Autoimmune Thyroid Diseases.

International journal of molecular sciences

Sacristán-Gómez P,Serrano-Somavilla A,Castro-Espadas L,Sánchez de la Blanca Carrero N,Sampedro-Núñez M,Muñoz-De-Nova JL,Molina-Jiménez F,Rosell A,Marazuela M,Martínez-Hernández R

Wed Feb 08 00:00:00 EST 2023

Evaluation of Epithelial-Mesenchymal Transition Markers in Autoimmune Thyroid Diseases.

International journal of molecular sciences

Sacristán-Gómez P,Serrano-Somavilla A,Castro-Espadas L,Sánchez de la Blanca Carrero N,Sampedro-Núñez M,Muñoz-De-Nova JL,Molina-Jiménez F,Rosell A,Marazuela M,Martínez-Hernández R

Wed Feb 08 00:00:00 EST 2023

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.

Neuron

Van Heurck R,Bonnefont J,Wojno M,Suzuki IK,Velez-Bravo FD,Erkol E,Nguyen DT,Herpoel A,Bilheu A,Beckers S,Ledent C,Vanderhaeghen P

Wed Jan 04 00:00:00 EST 2023

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.

The Journal of clinical investigation

Lee D,Gimple RC,Wu X,Prager BC,Qiu Z,Wu Q,Daggubati V,Mariappan A,Gopalakrishnan J,Sarkisian MR,Raleigh DR,Rich JN

Tue Jan 17 00:00:00 EST 2023

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.

The Journal of clinical investigation

Lee D,Gimple RC,Wu X,Prager BC,Qiu Z,Wu Q,Daggubati V,Mariappan A,Gopalakrishnan J,Sarkisian MR,Raleigh DR,Rich JN

Tue Jan 17 00:00:00 EST 2023

A SEC61A1 variant is associated with autosomal dominant polycystic liver disease.

Liver international : official journal of the International Association for the Study of the Liver

Schlevogt B,Schlieper V,Krader J,Schröter R,Wagner T,Weiand M,Zibert A,Schmidt HH,Bergmann C,Nedvetsky PI,Krahn MP

Wed Feb 01 00:00:00 EST 2023

An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.

Nature communications

Cao M,Zou X,Li C,Lin Z,Wang N,Zou Z,Ye Y,Seemann J,Levine B,Tang Z,Zhong Q

Mon Mar 27 00:00:00 EDT 2023

Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse.

bioRxiv : the preprint server for biology

Van Sciver RE,Long AB,Katz HG,Gigante ED,Caspary T

Mon May 15 00:00:00 EDT 2023

Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages.

bioRxiv : the preprint server for biology

Kanie T,Ng R,Abbott KL,Pongs O,Jackson PK

Tue Jan 10 00:00:00 EST 2023

TTBK2 mutations associated with spinocerebellar ataxia type 11 disrupt peroxisome dynamics and ciliary localization of SHH signaling proteins.

bioRxiv : the preprint server for biology

Muñoz-Estrada J,Nguyen AV,Goetz SC

Wed Feb 01 00:00:00 EST 2023

Increase in primary cilia number and length upon VDAC1 depletion contributes to attenuated proliferation of cancer cells.

Experimental cell research

Dutta A,Halder P,Gayen A,Mukherjee A,Mukherjee C,Majumder S

Tue Aug 15 00:00:00 EDT 2023

Ubiquitylation of BBSome is required for ciliary assembly and signaling.

EMBO reports

Chiuso F,Delle Donne R,Giamundo G,Rinaldi L,Borzacchiello D,Moraca F,Intartaglia D,Iannucci R,Senatore E,Lignitto L,Garbi C,Conflitti P,Catalanotti B,Conte I,Feliciello A

Wed Apr 05 00:00:00 EDT 2023

Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia.

Nature protocols

Gabriel E,Albanna W,Pasquini G,Ramani A,Josipovic N,Mariappan A,Riparbelli MG,Callaini G,Karch CM,Goureau O,Papantonis A,Busskamp V,Schneider T,Gopalakrishnan J

Thu Jun 01 00:00:00 EDT 2023

Primary cilia sense glutamine availability and respond via asparagine synthetase.

Nature metabolism

Steidl ME,Nigro EA,Nielsen AK,Pagliarini R,Cassina L,Lampis M,Podrini C,Chiaravalli M,Mannella V,Distefano G,Yang M,Aslanyan M,Musco G,Roepman R,Frezza C,Boletta A

Wed Mar 01 00:00:00 EST 2023

Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.

Life science alliance

Gregorczyk M,Pastore G,Muñoz I,Carroll T,Streubel J,Munro M,Lis P,Lange S,Lamoliatte F,Macartney T,Toth R,Brown F,Hastie J,Pereira G,Durocher D,Rouse J

Sat Jul 01 00:00:00 EDT 2023

Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse.

eLife

Li Y,Xu W,Makova S,Brueckner M,Sun Z

Wed Mar 15 00:00:00 EDT 2023

TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins.

Molecular biology of the cell

Nguyen A,Goetz SC

Sun Jan 01 00:00:00 EST 2023

Enhanced primary ciliogenesis via mitochondrial oxidative stress activates AKT to prevent neurotoxicity in HSPA9/mortalin-depleted SH-SY5Y cells.

Molecular brain

Bae JE,Jang S,Kim JB,Hyung H,Park NY,Kim YH,Kim SH,Kim SH,Ha JM,Oh GS,Park K,Jeong K,Jang JS,Jo DS,Kim P,Lee HS,Ryoo ZY,Cho DH

Thu May 11 00:00:00 EDT 2023

Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids.

Stem cells international

Ning K,Luo Z,Kowal TJ,Tran M,Majumder R,Jarin TM,Wu AY,Goldberg JL,Sun Y

Wed Feb 22 00:00:00 EST 2023

A targeted multi-proteomics approach generates a blueprint of the ciliary ubiquitinome.

Frontiers in cell and developmental biology

Aslanyan MG,Doornbos C,Diwan GD,Anvarian Z,Beyer T,Junger K,van Beersum SEC,Russell RB,Ueffing M,Ludwig A,Boldt K,Pedersen LB,Roepman R

Tue Feb 14 00:00:00 EST 2023

XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice.

Journal of the American Society of Nephrology : JASN

Krappitz M,Bhardwaj R,Dong K,Staudner T,Yilmaz DE,Pioppini C,Westergerling P,Ruemmele D,Hollmann T,Nguyen TA,Cai Y,Gallagher AR,Somlo S,Fedeles S

Sun Jan 01 00:00:00 EST 2023

A hierarchical pathway for assembly of the distal appendages that organize primary cilia.

bioRxiv : the preprint server for biology

Kanie T,Love JF,Fisher SD,Gustavsson AK,Jackson PK

Tue Jan 10 00:00:00 EST 2023

Investigations on Primary Cilia of Nthy-ori 3-1 Cells upon Cysteine Cathepsin Inhibition or Thyrotropin Stimulation.

International journal of molecular sciences

Doğru AG,Rehders M,Brix K

Fri May 26 00:00:00 EDT 2023

Eupatilin improves cilia defects in human CEP290 ciliopathy models.

bioRxiv : the preprint server for biology

Corral-Serrano JC,Sladen PE,Ottaviani D,Rezek FO,Jovanovic K,Athanasiou D,van der Spuy J,Mansfield BC,Cheetham ME

Wed Apr 12 00:00:00 EDT 2023

WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium.

Life science alliance

Cevik S,Peng X,Beyer T,Pir MS,Yenisert F,Woerz F,Hoffmann F,Altunkaynak B,Pir B,Boldt K,Karaman A,Cakiroglu M,Oner SS,Cao Y,Ueffing M,Kaplan OI

Tue Aug 01 00:00:00 EDT 2023

IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.

Science signaling

Li B,Yan YP,He YY,Liang C,Li MY,Wang Y,Yang ZM

Tue Feb 28 00:00:00 EST 2023

IHH, SHH, and primary cilia mediate epithelial-stromal cross-talk during decidualization in mice.

Science signaling

Li B,Yan YP,He YY,Liang C,Li MY,Wang Y,Yang ZM

Tue Feb 28 00:00:00 EST 2023

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

eLife

Hall EA,Kumar D,Prosser SL,Yeyati PL,Herranz-Pérez V,García-Verdugo JM,Rose L,McKie L,Dodd DO,Tennant PA,Megaw R,Murphy LC,Ferreira MF,Grimes G,Williams L,Quidwai T,Pelletier L,Reiter JF,Mill P

Wed Feb 15 00:00:00 EST 2023

DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression.

EMBO reports

Appiah B,Fullio CL,Ossola C,Bertani I,Restelli E,Cheffer A,Polenghi M,Haffner C,Garcia-Miralles M,Zeis P,Treppner M,Bovio P,Schlichtholz L,Mas-Sanchez A,Zografidou L,Winter J,Binder H,Grün D,Kalebic N,Taverna E,Vogel T

Thu Aug 03 00:00:00 EDT 2023

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis.

Developmental cell

Zhang K,Da Silva F,Seidl C,Wilsch-Bräuninger M,Herbst J,Huttner WB,Niehrs C

Mon Jan 23 00:00:00 EST 2023

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis.

Developmental cell

Zhang K,Da Silva F,Seidl C,Wilsch-Bräuninger M,Herbst J,Huttner WB,Niehrs C

Mon Jan 23 00:00:00 EST 2023

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis.

Developmental cell

Zhang K,Da Silva F,Seidl C,Wilsch-Bräuninger M,Herbst J,Huttner WB,Niehrs C

Mon Jan 23 00:00:00 EST 2023

Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis.

Developmental cell

Zhang K,Da Silva F,Seidl C,Wilsch-Bräuninger M,Herbst J,Huttner WB,Niehrs C

Mon Jan 23 00:00:00 EST 2023

Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia.

Molecular biology of the cell

Palicharla VR,Hwang SH,Somatilaka BN,Legué E,Shimada IS,Familiari NE,Tran VM,Woodruff JB,Liem KF,Mukhopadhyay S

Wed Mar 01 00:00:00 EST 2023

Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain.

Molecular therapy : the journal of the American Society of Gene Therapy

Ma R,Kutchy NA,Wang Z,Hu G

Wed May 03 00:00:00 EDT 2023

Scanning electron microscopy of human islet cilia.

Proceedings of the National Academy of Sciences of the United States of America

Polino AJ,Sviben S,Melena I,Piston DW,Hughes JW

Tue May 30 00:00:00 EDT 2023

Deficiency of the minor spliceosome component U4atac snRNA secondarily results in ciliary defects in human and zebrafish.

Proceedings of the National Academy of Sciences of the United States of America

Khatri D,Putoux A,Cologne A,Kaltenbach S,Besson A,Bertiaux E,Guguin J,Fendler A,Dupont MA,Benoit-Pilven C,Qebibo L,Ahmed-Elie S,Audebert-Bellanger S,Blanc P,Rambaud T,Castelle M,Cornen G,Grotto S,Guët A,Guibaud L,Michot C,Odent S,Ruaud L,Sacaze E,Hamel V,Bordonné R,Leutenegger AL,Edery P,Burglen L,Attié-Bitach T,Mazoyer S,Delous M

Tue Feb 28 00:00:00 EST 2023

CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.

BMC biology

Wang Y,Zhang Y,Guo X,Zheng Y,Zhang X,Feng S,Wu HY

Wed May 24 00:00:00 EDT 2023

PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation.

Cell death and differentiation

Zhang J,Yang Y,Li X,Li G,Mizukami T,Liu Y,Wang Y,Xu G,Roder H,Zhang L,Yang ZJ

Mon May 01 00:00:00 EDT 2023

PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation.

Cell death and differentiation

Zhang J,Yang Y,Li X,Li G,Mizukami T,Liu Y,Wang Y,Xu G,Roder H,Zhang L,Yang ZJ

Mon May 01 00:00:00 EDT 2023

Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus).

Frontiers in cell and developmental biology

Shylo NA,Smith SE,Price AJ,Guo F,McClain M,Trainor PA

Sun Apr 30 00:00:00 EDT 2023

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development.

Communications biology

Freitag K,Eede P,Ivanov A,Sterczyk N,Schneeberger S,Borodina T,Sauer S,Beule D,Heppner FL

Fri Jan 13 00:00:00 EST 2023

The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling.

The Journal of biological chemistry

Iwano T,Sobajima T,Takeda S,Harada A,Yoshimura SI

Wed Mar 01 00:00:00 EST 2023

The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling.

The Journal of biological chemistry

Iwano T,Sobajima T,Takeda S,Harada A,Yoshimura SI

Wed Mar 01 00:00:00 EST 2023

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

Journal of cell science

Shak C,Vuolo L,Uddin B,Katoh Y,Brown T,Mukhopadhyay AG,Heesom K,Roberts AJ,Stevenson N,Nakayama K,Stephens DJ

Wed Mar 01 00:00:00 EST 2023

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

Journal of cell science

Shak C,Vuolo L,Uddin B,Katoh Y,Brown T,Mukhopadhyay AG,Heesom K,Roberts AJ,Stevenson N,Nakayama K,Stephens DJ

Wed Mar 01 00:00:00 EST 2023

Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects.

eLife

Chen HY,Swaroop M,Papal S,Mondal AK,Song HB,Campello L,Tawa GJ,Regent F,Shimada H,Nagashima K,de Val N,Jacobson SG,Zheng W,Swaroop A

Tue Mar 28 00:00:00 EDT 2023

Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis.

Development (Cambridge, England)

Janečková E,Feng J,Guo T,Han X,Ghobadi A,Araujo-Villalba A,Rahman MS,Ziaei H,Ho TV,Pareek S,Alvarez J,Chai Y

Wed Mar 01 00:00:00 EST 2023

Agonists of prostaglandin E₂ receptors as potential first in class treatment for nephronophthisis and related ciliopathies.

Proceedings of the National Academy of Sciences of the United States of America

Garcia H,Serafin AS,Silbermann F,Porée E,Viau A,Mahaut C,Billot K,Birgy É,Garfa-Traore M,Roy S,Ceccarelli S,Mehraz M,Rodriguez PC,Deleglise B,Furio L,Jabot-Hanin F,Cagnard N,Del Nery E,Fila M,Sin-Monnot S,Antignac C,Lyonnet S,Krug P,Salomon R,Annereau JP,Benmerah A,Delous M,Briseño-Roa L,Saunier S

Tue May 03 00:00:00 EDT 2022

Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.

Structure (London, England : 1993)

Rosa E Silva I,Binó L,Johnson CM,Rutherford TJ,Neuhaus D,Andreeva A,Čajánek L,van Breugel M

Thu Jan 06 00:00:00 EST 2022

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease.

Nature communications

Schmidt S,Luecken MD,Trümbach D,Hembach S,Niedermeier KM,Wenck N,Pflügler K,Stautner C,Böttcher A,Lickert H,Ramirez-Suastegui C,Ahmad R,Ziller MJ,Fitzgerald JC,Ruf V,van de Berg WDJ,Jonker AJ,Gasser T,Winner B,Winkler J,Vogt Weisenhorn DM,Giesert F,Theis FJ,Wurst W

Tue Aug 16 00:00:00 EDT 2022

Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Reilly ML,Ain NU,Muurinen M,Tata A,Huber C,Simon M,Ishaq T,Shaw N,Rusanen S,Pekkinen M,Högler W,Knapen MFCM,van den Born M,Saunier S,Naz S,Cormier-Daire V,Benmerah A,Makitie O

Thu Sep 01 00:00:00 EDT 2022

Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein.

Frontiers in cell and developmental biology

An HL,Kuo HC,Tang TK

Tue Mar 22 00:00:00 EDT 2022

Precise control of microtubule disassembly in living cells.

The EMBO journal

Liu GY,Chen SC,Lee GH,Shaiv K,Chen PY,Cheng H,Hong SR,Yang WT,Huang SH,Chang YC,Wang HC,Kao CL,Sun PC,Chao MH,Lee YY,Tang MJ,Lin YC

Mon Aug 01 00:00:00 EDT 2022

ATM- and ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma.

Journal of cellular physiology

Chao YY,Huang BM,Peng IC,Lee PR,Lai YS,Chiu WT,Lin YS,Lin SC,Chang JH,Chen PS,Tsai SJ,Wang CY

Thu Dec 01 00:00:00 EST 2022

Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology.

Cancers

Barbarino M,Bottaro M,Spagnoletti L,de Santi MM,Guazzo R,Defraia C,Custoza C,Serio G,Iannelli F,Pesetti M,Aiello R,Rosati D,Zanfrini E,Luzzi L,Bellan C,Giordano A

Tue Oct 25 00:00:00 EDT 2022

Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology.

Cancers

Barbarino M,Bottaro M,Spagnoletti L,de Santi MM,Guazzo R,Defraia C,Custoza C,Serio G,Iannelli F,Pesetti M,Aiello R,Rosati D,Zanfrini E,Luzzi L,Bellan C,Giordano A

Tue Oct 25 00:00:00 EDT 2022

GLI transcriptional repression is inert prior to Hedgehog pathway activation.

Nature communications

Lex RK,Zhou W,Ji Z,Falkenstein KN,Schuler KE,Windsor KE,Kim JD,Ji H,Vokes SA

Thu Feb 10 00:00:00 EST 2022

Biallelic variants in CENPF causing a phenotype distinct from Strømme syndrome.

American journal of medical genetics. Part C, Seminars in medical genetics

Cappuccio G,Brillante S,Tammaro R,Pinelli M,De Bernardi ML,Gensini MG,Bijlsma EK,Koopmann TT,Hoffer MJV,McDonald K,Hendon LG,Douzgou S,Deshpande C,D'Arrigo S,Torella A,Nigro V,Franco B,Brunetti-Pierri N

Tue Mar 01 00:00:00 EST 2022

A protocol for generation and live-cell imaging analysis of primary cilia reporter cell lines.

STAR protocols

Binó L,Mikulenková E,Štepánek L,Bernatík O,Vysloužil D,Pejšková P,Gorilák P,Huranová M,Varga V,Čajánek L

Fri Mar 18 00:00:00 EDT 2022

Renal primary cilia lengthen in the progression of diabetic kidney disease.

Frontiers in endocrinology

Bai Y,Li P,Liu J,Zhang L,Cui S,Wei C,Fu B,Sun X,Cai G,Hong Q,Chen X

Tue Dec 06 00:00:00 EST 2022

Evolutionarily conserved genetic interactions between nphp-4 and bbs-5 mutations exacerbate ciliopathy phenotypes.

Genetics

Bentley-Ford MR,LaBonty M,Thomas HR,Haycraft CJ,Scott M,LaFayette C,Croyle MJ,Andersen RS,Parant JM,Yoder BK

Tue Jan 04 00:00:00 EST 2022

A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution.

Scientific reports

Ijaz F,Nakazato R,Setou M,Ikegami K

Fri Jul 08 00:00:00 EDT 2022

Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells.

Biomedical and environmental sciences : BES

Wei L,Ma W,Cai H,Peng SP,Tian HB,Wang JF,Gao L,He JP

Fri May 20 00:00:00 EDT 2022

Islet primary cilia motility controls insulin secretion.

Science advances

Cho JH,Li ZA,Zhu L,Muegge BD,Roseman HF,Lee EY,Utterback T,Woodhams LG,Bayly PV,Hughes JW

Fri Sep 23 00:00:00 EDT 2022

Nuclear factor (erythroid-derived 2)-like 2 counter-regulates thymosin beta-4 expression and primary cilium formation for HeLa cervical cancer cell survival.

Scientific reports

Lee JW,Thuy PX,Koo JH,Moon EY

Wed Nov 23 00:00:00 EST 2022

TTC30A and TTC30B Redundancy Protects IFT Complex B Integrity and Its Pivotal Role in Ciliogenesis.

Genes

Hoffmann F,Bolz S,Junger K,Klose F,Schubert T,Woerz F,Boldt K,Ueffing M,Beyer T

Fri Jul 01 00:00:00 EDT 2022

FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation.

Scientific reports

Czerny CC,Borschel A,Cai M,Otto M,Hoyer-Fender S

Mon Dec 12 00:00:00 EST 2022

IFT-A structure reveals carriages for membrane protein transport into cilia.

Cell

Hesketh SJ,Mukhopadhyay AG,Nakamura D,Toropova K,Roberts AJ

Thu Dec 22 00:00:00 EST 2022

The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila.

Experimental cell research

Guleria VS,Parit R,Quadri N,Das R,Upadhyai P

Thu Sep 15 00:00:00 EDT 2022

The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity.

Journal of cell science

Smit MJ,Martini TEI,Armandari I,Bočkaj I,Zomerman WW,de Camargo Magalhães ES,Siragna Z,Meeuwsen TGJ,Scherpen FJG,Schoots MH,Ritsema M,den Dunnen WFA,Hoving EW,Paridaen JTML,de Haan G,Guryev V,Bruggeman SWM

Wed Jun 01 00:00:00 EDT 2022

KIAA0319 influences cilia length, cell migration and mechanical cell-substrate interaction.

Scientific reports

Diaz R,Kronenberg NM,Martinelli A,Liehm P,Riches AC,Gather MC,Paracchini S

Fri Jan 14 00:00:00 EST 2022

Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.

Molecular biology of the cell

Dewees SI,Vargová R,Hardin KR,Turn RE,Devi S,Linnert J,Wolfrum U,Caspary T,Eliáš M,Kahn RA

Fri Apr 01 00:00:00 EDT 2022

Non-cell-autonomous activation of hedgehog signaling contributes to disease progression in a mouse model of renal cystic ciliopathy.

Human molecular genetics

Hsieh CL,Jerman SJ,Sun Z

Fri Dec 16 00:00:00 EST 2022

Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Coveney CR,Samvelyan HJ,Miotla-Zarebska J,Carnegie J,Chang E,Corrin CJ,Coveney T,Stott B,Parisi I,Duarte C,Vincent TL,Staines KA,Wann AK

Wed Jun 01 00:00:00 EDT 2022

Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Coveney CR,Samvelyan HJ,Miotla-Zarebska J,Carnegie J,Chang E,Corrin CJ,Coveney T,Stott B,Parisi I,Duarte C,Vincent TL,Staines KA,Wann AK

Wed Jun 01 00:00:00 EDT 2022

HeLa Cervical Cancer Cells Are Maintained by Nephronophthisis 3-Associated Primary Cilium Formation via ROS-Induced ERK and HIF-1α Activation under Serum-Deprived Normoxic Condition.

International journal of molecular sciences

Lee JW,Cho JY,Thuy PX,Moon EY

Tue Nov 22 00:00:00 EST 2022

A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.

Nature structural & molecular biology

Happ JT,Arveseth CD,Bruystens J,Bertinetti D,Nelson IB,Olivieri C,Zhang J,Hedeen DS,Zhu JF,Capener JL,Bröckel JW,Vu L,King CC,Ruiz-Perez VL,Ge X,Veglia G,Herberg FW,Taylor SS,Myers BR

Sat Oct 01 00:00:00 EDT 2022

A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma.

Cell reports methods

Dittrich T,Köhrer S,Schorb M,Haberbosch I,Börmel M,Goldschmidt H,Pajor G,Müller-Tidow C,Raab MS,Hegenbart U,Schönland SO,Schwab Y,Krämer A

Mon Nov 21 00:00:00 EST 2022

Pyrogallol-Phloroglucinol-6, 6-Bieckol Restored Primary Cilia Length, Which Was Decreased by High-Fat Diet in Visceral Adipose Tissue, and Decreased Adipogenesis.

International journal of endocrinology

Oh S,Son M,Jang JT,Park CH,Son KH,Byun K

Sat Jul 16 00:00:00 EDT 2022

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.

eLife

Jang DG,Kwon KY,Kweon YC,Kim BG,Myung K,Lee HS,Young Park C,Kwon T,Park TJ

Thu Aug 25 00:00:00 EDT 2022

Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines.

PloS one

Gómez AE,Christman AK,Van De Weghe JC,Finn M,Doherty D

Mon Jan 02 00:00:00 EST 2023

The carboxyl-terminal region of SDCCAG8 comprises a functional module essential for cilia formation as well as organ development and homeostasis.

The Journal of biological chemistry

Tsutsumi R,Chaya T,Tsujii T,Furukawa T

Tue Mar 01 00:00:00 EST 2022

Identification of a novel variant of the ciliopathic gene FUZZY associated with craniosynostosis.

European journal of human genetics : EJHG

Barrell WB,Adel Al-Lami H,Goos JAC,Swagemakers SMA,van Dooren M,Torban E,van der Spek PJ,Mathijssen IMJ,Liu KJ

Tue Mar 01 00:00:00 EST 2022

KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency-Related Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN

Rah G,Cha H,Kim J,Song J,Kim H,Oh YK,Ahn C,Kang M,Kim J,Yoo KH,Kim MJ,Ko HW,Ko JY,Park JH

Thu Sep 01 00:00:00 EDT 2022

Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.

Molecular biology of the cell

Yue Y,Engelke MF,Blasius TL,Verhey KJ

Sat Jan 01 00:00:00 EST 2022

Preliminary results on a proposed histopathological assessment of predictive factors for basal cell carcinoma recurrence after primary free margin excision.

Skin health and disease

Jacquet A,Dormoy V,Lorenzato M,Durlach A

Wed Jun 01 00:00:00 EDT 2022

TMED2 binding restricts SMO to the ER and Golgi compartments.

PLoS biology

Di Minin G,Holzner M,Grison A,Dumeau CE,Chan W,Monfort A,Jerome-Majewska LA,Roelink H,Wutz A

Tue Mar 01 00:00:00 EST 2022

Cilia proteins are biomarkers of altered flow in the vasculature.

JCI insight

Gupta A,Thirugnanam K,Thamilarasan M,Mohieldin AM,Zedan HT,Prabhudesai S,Griffin MR,Spearman AD,Pan A,Palecek SP,Yalcin HC,Nauli SM,Rarick KR,Zennadi R,Ramchandran R

Tue Mar 22 00:00:00 EDT 2022

Cilia proteins are biomarkers of altered flow in the vasculature.

JCI insight

Gupta A,Thirugnanam K,Thamilarasan M,Mohieldin AM,Zedan HT,Prabhudesai S,Griffin MR,Spearman AD,Pan A,Palecek SP,Yalcin HC,Nauli SM,Rarick KR,Zennadi R,Ramchandran R

Tue Mar 22 00:00:00 EDT 2022

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.

Cell death & disease

Ávalos Y,Hernández-Cáceres MP,Lagos P,Pinto-Nuñez D,Rivera P,Burgos P,Díaz-Castro F,Joy-Immediato M,Venegas-Zamora L,Lopez-Gallardo E,Kretschmar C,Batista-Gonzalez A,Cifuentes-Araneda F,Toledo-Valenzuela L,Rodriguez-Peña M,Espinoza-Caicedo J,Perez-Leighton C,Bertocchi C,Cerda M,Troncoso R,Parra V,Budini M,Burgos PV,Criollo A,Morselli E

Thu Jul 28 00:00:00 EDT 2022

Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism.

Cell death & disease

Thu Jul 28 00:00:00 EDT 2022

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.

Biology open

Lara Ordóñez AJ,Fasiczka R,Fernández B,Naaldijk Y,Fdez E,Blanca Ramírez M,Phan S,Boassa D,Hilfiker S

Mon Aug 15 00:00:00 EDT 2022

Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.

Cell research

Wang L,Paudyal SC,Kang Y,Owa M,Liang FX,Spektor A,Knaut H,Sánchez I,Dynlacht BD

Tue Feb 01 00:00:00 EST 2022

Physical Exercise-Induced Astrocytic Neuroprotection and Cognitive Improvement Through Primary Cilia and Mitogen-Activated Protein Kinases Pathway in Rats With Chronic Cerebral Hypoperfusion.

Frontiers in aging neuroscience

Cao W,Lin J,Xiang W,Liu J,Wang B,Liao W,Jiang T

Sat Jul 16 00:00:00 EDT 2022

Heterogeneity of the NIH3T3 Fibroblast Cell Line.

Cells

Rahimi AM,Cai M,Hoyer-Fender S

Sun Aug 28 00:00:00 EDT 2022

Monoallelic pathogenic ALG5 variants cause atypical polycystic kidney disease and interstitial fibrosis.

American journal of human genetics

Lemoine H,Raud L,Foulquier F,Sayer JA,Lambert B,Olinger E,Lefèvre S,Knebelmann B,Harris PC,Trouvé P,Desprès A,Duneau G,Matignon M,Poyet A,Jourde-Chiche N,Guerrot D,Lemoine S,Seret G,Barroso-Gil M,Bingham C,Gilbert R,Le Meur Y,Audrézet MP,Cornec-Le Gall E

Thu Aug 04 00:00:00 EDT 2022

Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells.

Cells

Chu Z,Gruss OJ

Fri Apr 01 00:00:00 EDT 2022

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus.

Frontiers in cellular and infection microbiology

Ekanger CT,Zhou F,Bohan D,Lotsberg ML,Ramnefjell M,Hoareau L,Røsland GV,Lu N,Aanerud M,Gärtner F,Salminen PR,Bentsen M,Halvorsen T,Ræder H,Akslen LA,Langeland N,Cox R,Maury W,Stuhr LEB,Lorens JB,Engelsen AST

Tue Apr 05 00:00:00 EDT 2022

Evolutionary conservation of centriole rotational asymmetry in the human centrosome.

eLife

Gaudin N,Martin Gil P,Boumendjel M,Ershov D,Pioche-Durieu C,Bouix M,Delobelle Q,Maniscalco L,Phan TBN,Heyer V,Reina-San-Martin B,Azimzadeh J

Wed Mar 23 00:00:00 EDT 2022

Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.

Traffic (Copenhagen, Denmark)

Jones T,Naslavsky N,Caplan S

Fri Jul 01 00:00:00 EDT 2022

Porcine choroid plexus-Riems cell line demonstrates altered polarization of transport proteins compared with the native epithelium.

American journal of physiology. Cell physiology

Hochstetler A,Hulme L,Delpire E,Schwerk C,Schroten H,Preston D,Simpson S,Blazer-Yost BL

Fri Jul 01 00:00:00 EDT 2022

Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia.

Nature biomedical engineering

Cruz NM,Reddy R,McFaline-Figueroa JL,Tran C,Fu H,Freedman BS

Fri Apr 01 00:00:00 EDT 2022

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations.

Frontiers in genetics

Nazlamova L,Villa Vasquez SS,Lord J,Karthik V,Cheung MK,Lakowski J,Wheway G

Sat Oct 01 00:00:00 EDT 2022

Plexins promote Hedgehog signaling through their cytoplasmic GAP activity.

eLife

Pinskey JM,Hoard TM,Zhao XF,Franks NE,Frank ZC,McMellen AN,Giger RJ,Allen BL

Wed Sep 28 00:00:00 EDT 2022

Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia.

Bone research

Martin L,Kaci N,Benoist-Lasselin C,Mondoloni M,Decaudaveine S,Estibals V,Cornille M,Loisay L,Flipo J,Demuynck B,de la Luz Cádiz-Gurrea M,Barbault F,Fernández-Arroyo S,Schibler L,Segura-Carretero A,Dambroise E,Legeai-Mallet L

Tue Jan 25 00:00:00 EST 2022

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling.

Cell reports

Schembs L,Willems A,Hasenpusch-Theil K,Cooper JD,Whiting K,Burr K,Bøstrand SMK,Selvaraj BT,Chandran S,Theil T

Tue May 17 00:00:00 EDT 2022

Primary Cilia Restrain PI3K-AKT Signaling to Orchestrate Human Decidualization.

International journal of molecular sciences

Li B,Yan YP,Liang C,He YY,Wang Y,Li MY,Chen ST,Li Y,Liu AX,Yan GJ,Yang ZM

Thu Dec 08 00:00:00 EST 2022

Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.

Cell stem cell

Ungricht R,Guibbal L,Lasbennes MC,Orsini V,Beibel M,Waldt A,Cuttat R,Carbone W,Basler A,Roma G,Nigsch F,Tchorz JS,Hoepfner D,Hoppe PS

Thu Jan 06 00:00:00 EST 2022

Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling.

JCI insight

Shi H,Wang H,Zhang C,Lu Y,Yao J,Chen Z,Xing G,Wei Q,Cao X

Tue Feb 22 00:00:00 EST 2022

Cytoskeletal Protein 4.1G Is Essential for the Primary Ciliogenesis and Osteoblast Differentiation in Bone Formation.

International journal of molecular sciences

Saito M,Hirano M,Izumi T,Mori Y,Ito K,Saitoh Y,Terada N,Sato T,Sukegawa J

Mon Feb 14 00:00:00 EST 2022

AMBRA1 p.Gln30Arg Mutation, Identified in a Cowden Syndrome Family, Exhibits Hyperproliferative Potential in hTERT-RPE1 Cells.

International journal of molecular sciences

Revathidevi S,Hosomichi K,Natsume T,Nakaoka H,Fujito NT,Akatsuka H,Sato T,Munirajan AK,Inoue I

Thu Sep 22 00:00:00 EDT 2022

Chondrocyte-specific response to stiffness-mediated primary cilia formation and centriole positioning.

American journal of physiology. Cell physiology

Williantarra I,Leung S,Choi YS,Chhana A,McGlashan SR

Fri Jul 01 00:00:00 EDT 2022

3D-Structured Illumination Microscopy of Centrosomes in Human Cell Lines.

Bio-protocol

Frikstad KM,Schink KO,Gilani S,Pedersen LB,Patzke S

Sun Mar 20 00:00:00 EDT 2022

Soft, Dynamic Hydrogel Confinement Improves Kidney Organoid Lumen Morphology and Reduces Epithelial-Mesenchymal Transition in Culture.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Ruiter FAA,Morgan FLC,Roumans N,Schumacher A,Slaats GG,Moroni L,LaPointe VLS,Baker MB

Fri Jul 01 00:00:00 EDT 2022

Characterization of TRPV4-mediated signaling pathways in an optimized human choroid plexus epithelial cell line.

American journal of physiology. Cell physiology

Hulme L,Hochstetler A,Schwerk C,Schroten H,Ishikawa H,Tung CY,Perrin B,Blazer-Yost B

Thu Dec 01 00:00:00 EST 2022

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate.

Cell research

Hu A,Zhang JZ,Wang J,Li CC,Yuan M,Deng G,Lin ZC,Qiu ZP,Liu HY,Wang XW,Wei PC,He X,Zhao X,Qiu WW,Song BL

Tue Mar 01 00:00:00 EST 2022

Deletion of CEP164 in mouse photoreceptors post-ciliogenesis interrupts ciliary intraflagellar transport (IFT).

PLoS genetics

Reed M,Takemaru KI,Ying G,Frederick JM,Baehr W

Thu Sep 01 00:00:00 EDT 2022

Concurrent Germline and Somatic Mutations in FLCN and Preliminary Exploration of Its Function: A Case Report.

Frontiers in oncology

Wang T,Yang Y,Feng H,Cui B,Lv Z,Zhao W,Zhang X,Ma X

Sun Nov 05 00:00:00 EDT 2023

ALKBH3-dependent m¹A demethylation of Aurora A mRNA inhibits ciliogenesis.

Cell discovery

Kuang W,Jin H,Yang F,Chen X,Liu J,Li T,Chang Y,Liu M,Xu Z,Huo C,Yan X,Yang Y,Liu W,Shu Q,Xie S,Zhou T

Fri Mar 11 00:00:00 EST 2022

LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.

The Journal of cell biology

Shen XL,Yuan JF,Qin XH,Song GP,Hu HB,Tu HQ,Song ZQ,Li PY,Xu YL,Li S,Jian XX,Li JN,He CY,Yu XP,Liang LY,Wu M,Han QY,Wang K,Li AL,Zhou T,Zhang YC,Wang N,Li HY

Mon Jan 03 00:00:00 EST 2022

Ciliary Proteins Repurposed by the Synaptic Ribbon: Trafficking Myristoylated Proteins at Rod Photoreceptor Synapses.

International journal of molecular sciences

Suiwal S,Dembla M,Schwarz K,Katiyar R,Jung M,Carius Y,Maxeiner S,Lauterbach MA,Lancaster CRD,Schmitz F

Mon Jun 27 00:00:00 EDT 2022

Hedgehog signaling is controlled by Rac1 activity.

Theranostics

Tang C,Wu X,Ren Q,Yao M,Xu S,Yan Z

Thu Apr 21 00:00:00 EDT 2022

ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the lamprey central canal.

eLife

Jalalvand E,Alvelid J,Coceano G,Edwards S,Robertson B,Grillner S,Testa I

Tue Feb 01 00:00:00 EST 2022

CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia.

EMBO molecular medicine

He L,Arnold C,Thoma J,Rohde C,Kholmatov M,Garg S,Hsiao CC,Viol L,Zhang K,Sun R,Schmidt C,Janssen M,MacRae T,Huber K,Thiede C,Hébert J,Sauvageau G,Spratte J,Fluhr H,Aust G,Müller-Tidow C,Niehrs C,Pereira G,Hamann J,Tanaka M,Zaugg JB,Pabst C

Thu Apr 07 00:00:00 EDT 2022

Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yang D,Wu X,Wang W,Zhou Y,Wang Z

Sat Jan 01 00:00:00 EST 2022

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling.

Cell reports

Sivakumar S,Qi S,Cheng N,Sathe AA,Kanchwala M,Kumar A,Evers BM,Xing C,Yu H

Tue Feb 15 00:00:00 EST 2022

C2cd6-encoded CatSperτ targets sperm calcium channel to Ca²⁺ signaling domains in the flagellar membrane.

Cell reports

Hwang JY,Wang H,Lu Y,Ikawa M,Chung JJ

Tue Jan 18 00:00:00 EST 2022

LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport.

Journal of cell science

Hanafusa H,Kedashiro S,Gotoh M,Saitoh KH,Inaba H,Nishioka T,Kaibuchi K,Inagaki M,Hisamoto N,Matsumoto K

Tue Nov 01 00:00:00 EDT 2022

Mutations in SCNM1 cause orofaciodigital syndrome due to minor intron splicing defects affecting primary cilia.

American journal of human genetics

Iturrate A,Rivera-Barahona A,Flores CL,Otaify GA,Elhossini R,Perez-Sanz ML,Nevado J,Tenorio-Castano J,Triviño JC,Garcia-Gonzalo FR,Piceci-Sparascio F,De Luca A,Martínez L,Kalaycı T,Lapunzina P,Altunoglu U,Aglan M,Abdalla E,Ruiz-Perez VL

Thu Oct 06 00:00:00 EDT 2022

Primary Cilium by Polyinosinic:Polycytidylic Acid Regulates the Regenerative Migration of Beas-2B Bronchial Epithelial Cells.

Biomolecules & therapeutics

Gweon B,Jang TK,Thuy PX,Moon EY

Tue Mar 01 00:00:00 EST 2022

Modulation of Primary Cilia by Alvocidib Inhibition of CILK1.

International journal of molecular sciences

Wang EX,Turner JS,Brautigan DL,Fu Z

Sat Jul 23 00:00:00 EDT 2022

Primary cilia suppress Ripk3-mediated necroptosis.

Cell death discovery

Kieckhöfer E,Slaats GG,Ebert LK,Albert MC,Dafinger C,Kashkar H,Benzing T,Schermer B

Fri Dec 02 00:00:00 EST 2022

Subtype-Selective Positive Modulation of K_Ca2.3 Channels Increases Cilia Length.

ACS chemical biology

Nam YW,Pala R,El-Sayed NS,Larin-Henriquez D,Amirrad F,Yang G,Rahman MA,Orfali R,Downey M,Parang K,Nauli SM,Zhang M

Fri Aug 19 00:00:00 EDT 2022

Metabolomic fingerprinting of renal disease progression in Bardet-Biedl syndrome reveals mitochondrial dysfunction in kidney tubular cells.

iScience

Marchese E,Caterino M,Viggiano D,Cevenini A,Tolone S,Docimo L,Di Iorio V,Del Vecchio Blanco F,Fedele R,Simonelli F,Perna A,Nigro V,Capasso G,Ruoppolo M,Zacchia M

Fri Nov 18 00:00:00 EST 2022

Midbody plays an active role in fibroblast-myofibroblast transition by mediating TGF-β signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jung SW,Kim SM,Kim A,Park SH,Moon JY,Lee SH

Sun May 01 00:00:00 EDT 2022

Midbody plays an active role in fibroblast-myofibroblast transition by mediating TGF-β signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jung SW,Kim SM,Kim A,Park SH,Moon JY,Lee SH

Sun May 01 00:00:00 EDT 2022

Midbody plays an active role in fibroblast-myofibroblast transition by mediating TGF-β signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jung SW,Kim SM,Kim A,Park SH,Moon JY,Lee SH

Sun May 01 00:00:00 EDT 2022

Midbody plays an active role in fibroblast-myofibroblast transition by mediating TGF-β signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jung SW,Kim SM,Kim A,Park SH,Moon JY,Lee SH

Sun May 01 00:00:00 EDT 2022

Endothelial β-arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia.

Pulmonary circulation

Park S,Ma Z,Zarkada G,Papangeli I,Paluri S,Nazo N,Rivera-Molina F,Toomre D,Rajagopal S,Chun HJ

Sat Oct 01 00:00:00 EDT 2022

Carnitine Protects against MPP⁺-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells.

Cells

Bae JE,Kim JB,Jo DS,Park NY,Kim YH,Lee HJ,Kim SH,Kim SH,Son M,Kim P,Ryu HY,Lee WH,Ryoo ZY,Lee HS,Jung YK,Cho DH

Thu Sep 01 00:00:00 EDT 2022

KIF24 depletion induces clustering of supernumerary centrosomes in PDAC cells.

Life science alliance

Mashima Y,Nohira H,Sugihara H,Dynlacht BD,Kobayashi T,Itoh H

Tue Nov 01 00:00:00 EDT 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

The N-terminal Leu-Pro-Gln sequence of Rab34 is required for ciliogenesis in hTERT-RPE1 cells.

Small GTPases

Oguchi ME,Homma Y,Fukuda M

Sat Jan 01 00:00:00 EST 2022

The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.

Molecular biology of the cell

Turn RE,Hu Y,Dewees SI,Devi N,East MP,Hardin KR,Khatib T,Linnert J,Wolfrum U,Lim MJ,Casanova JE,Caspary T,Kahn RA

Tue Feb 01 00:00:00 EST 2022

The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients.

Cells

Saber Cherif L,Diabasana Z,Perotin JM,Ancel J,Petit LMG,Devilliers MA,Bonnomet A,Lalun N,Delepine G,Maskos U,Gosset P,Polette M,Muggeo A,Guillard T,Deslée G,Dormoy V

Tue Sep 20 00:00:00 EDT 2022

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.

iScience

Fdez E,Madero-Pérez J,Lara Ordóñez AJ,Naaldijk Y,Fasiczka R,Aiastui A,Ruiz-Martínez J,López de Munain A,Cowley SA,Wade-Martins R,Hilfiker S

Fri Jun 17 00:00:00 EDT 2022

Biallelic loss-of-function variants in EXOC6B are associated with impaired primary ciliogenesis and cause spondylo-epi-metaphyseal dysplasia with joint laxity type 3.

Human mutation

Simsek-Kiper PO,Jacob P,Upadhyai P,Taşkıran ZE,Guleria VS,Karaosmanoglu B,Imren G,Gocmen R,Bhavani GS,Kausthubham N,Shah H,Utine GE,Boduroglu K,Girisha KM

Thu Dec 01 00:00:00 EST 2022

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.

EMBO reports

Hansen JN,Kaiser F,Leyendecker P,Stüven B,Krause JH,Derakhshandeh F,Irfan J,Sroka TJ,Preval KM,Desai PB,Kraut M,Theis H,Drews AD,De-Domenico E,Händler K,Pazour GJ,Henderson DJP,Mick DU,Wachten D

Wed Aug 03 00:00:00 EDT 2022

Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling.

Journal of cell science

Morthorst SK,Nielsen C,Farinelli P,Anvarian Z,Rasmussen CBR,Serra-Marques A,Grigoriev I,Altelaar M,Fürstenberg N,Ludwig A,Akhmanova A,Christensen ST,Pedersen LB

Wed Jun 15 00:00:00 EDT 2022

Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.

Cell death and differentiation

Li Q,Han Z,Singh N,Terré B,Fame RM,Arif U,Page TD,Zahran T,Abdeltawab A,Huang Y,Cao P,Wang J,Lu H,Lidov HGW,Surendran K,Wu L,Virga JQ,Zhao YT,Schüller U,Wechsler-Reya RJ,Lehtinen MK,Roy S,Liu Z,Stracker TH,Zhao H

Mon Aug 01 00:00:00 EDT 2022

Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.

Biochemical pharmacology

Thirugnanam K,Prabhudesai S,Van Why E,Pan A,Gupta A,Foreman K,Zennadi R,Rarick KR,Nauli SM,Palecek SP,Ramchandran R

Mon Aug 01 00:00:00 EDT 2022

Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.

Biochemical pharmacology

Thirugnanam K,Prabhudesai S,Van Why E,Pan A,Gupta A,Foreman K,Zennadi R,Rarick KR,Nauli SM,Palecek SP,Ramchandran R

Mon Aug 01 00:00:00 EDT 2022

Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.

Biochemical pharmacology

Thirugnanam K,Prabhudesai S,Van Why E,Pan A,Gupta A,Foreman K,Zennadi R,Rarick KR,Nauli SM,Palecek SP,Ramchandran R

Mon Aug 01 00:00:00 EDT 2022

Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability.

Biochemical pharmacology

Thirugnanam K,Prabhudesai S,Van Why E,Pan A,Gupta A,Foreman K,Zennadi R,Rarick KR,Nauli SM,Palecek SP,Ramchandran R

Mon Aug 01 00:00:00 EDT 2022

Fluorescence imaging of beta cell primary cilia.

Frontiers in endocrinology

Li ZA,Cho JH,Woodhams LG,Hughes JW

Tue Oct 11 00:00:00 EDT 2022

A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy.

International journal of molecular sciences

Fan J,Zhao Z,Liu R,Li H,He W,Wu J,Wang Y,Chen W

Tue Nov 22 00:00:00 EST 2022

Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yamakawa D,Tsuboi J,Kasahara K,Matsuda C,Nishimura Y,Kodama T,Katayama N,Watanabe M,Inagaki M

Mon Nov 14 00:00:00 EST 2022

Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling.

Genetics in medicine : official journal of the American College of Medical Genetics

Holtz AM,VanCoillie R,Vansickle EA,Carere DA,Withrow K,Torti E,Juusola J,Millan F,Person R,Guillen Sacoto MJ,Si Y,Wentzensen IM,Pugh J,Vasileiou G,Rieger M,Reis A,Argilli E,Sherr EH,Aldinger KA,Dobyns WB,Brunet T,Hoefele J,Wagner M,Haber B,Kotzaeridou U,Keren B,Heron D,Mignot C,Heide S,Courtin T,Buratti J,Murugasen S,Donald KA,O'Heir E,Moody S,Kim KH,Burton BK,Yoon G,Campo MD,Masser-Frye D,Kozenko M,Parkinson C,Sell SL,Gordon PL,Prokop JW,Karaa A,Bupp C,Raby BA

Sat Oct 01 00:00:00 EDT 2022

Control of meiotic chromosomal bouquet and germ cell morphogenesis by the zygotene cilium.

Science (New York, N.Y.)

Mytlis A,Kumar V,Qiu T,Deis R,Hart N,Levy K,Masek M,Shawahny A,Ahmad A,Eitan H,Nather F,Adar-Levor S,Birnbaum RY,Elia N,Bachmann-Gagescu R,Roy S,Elkouby YM

Fri Jun 17 00:00:00 EDT 2022

Distribution of prototypical primary cilia markers in subtypes of retinal ganglion cells.

The Journal of comparative neurology

Kowal TJ,Dhande OS,Wang B,Wang Q,Ning K,Liu W,Berbari NF,Hu Y,Sun Y

Mon Aug 01 00:00:00 EDT 2022

The Primary Ciliary Deficits in Cerebellar Bergmann Glia of the Mouse Model of Fragile X Syndrome.

Cerebellum (London, England)

Lee B,Beuhler L,Lee HY

Sat Oct 01 00:00:00 EDT 2022

TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human.

Frontiers in molecular neuroscience

Delalande JM,Nagy N,McCann CJ,Natarajan D,Cooper JE,Carreno G,Dora D,Campbell A,Laurent N,Kemos P,Thomas S,Alby C,Attié-Bitach T,Lyonnet S,Logan MP,Goldstein AM,Davey MG,Hofstra RMW,Thapar N,Burns AJ

Sat Jul 16 00:00:00 EDT 2022

Loss of Ciliary Gene Bbs8 Results in Physiological Defects in the Retinal Pigment Epithelium.

Frontiers in cell and developmental biology

Schneider S,De Cegli R,Nagarajan J,Kretschmer V,Matthiessen PA,Intartaglia D,Hotaling N,Ueffing M,Boldt K,Conte I,May-Simera HL

Wed Mar 10 00:00:00 EST 2021

A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities.

Human molecular genetics

Bentley-Ford MR,Engle SE,Clearman KR,Haycraft CJ,Andersen RS,Croyle MJ,Rains AB,Berbari NF,Yoder BK

Mon Apr 26 00:00:00 EDT 2021

Roles for ELMOD2 and Rootletin in ciliogenesis.

Molecular biology of the cell

Turn RE,Linnert J,Gigante ED,Wolfrum U,Caspary T,Kahn RA

Thu Apr 15 00:00:00 EDT 2021

Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.

Developmental dynamics : an official publication of the American Association of Anatomists

Gailey CD,Wang EJ,Jin L,Ahmadi S,Brautigan DL,Li X,Xu W,Scott MM,Fu Z

Mon Feb 01 00:00:00 EST 2021

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

Molecular cell

Piette BL,Alerasool N,Lin ZY,Lacoste J,Lam MHY,Qian WW,Tran S,Larsen B,Campos E,Peng J,Gingras AC,Taipale M

Thu Jun 17 00:00:00 EDT 2021

CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images.

The European physical journal. E, Soft matter

Hansen JN,Rassmann S,Stüven B,Jurisch-Yaksi N,Wachten D

Mon Mar 08 00:00:00 EST 2021

Time-resolved proteomics profiling of the ciliary Hedgehog response.

The Journal of cell biology

May EA,Kalocsay M,D'Auriac IG,Schuster PS,Gygi SP,Nachury MV,Mick DU

Mon May 03 00:00:00 EDT 2021

Time-resolved proteomics profiling of the ciliary Hedgehog response.

The Journal of cell biology

May EA,Kalocsay M,D'Auriac IG,Schuster PS,Gygi SP,Nachury MV,Mick DU

Mon May 03 00:00:00 EDT 2021

Modeling retinitis pigmentosa through patient-derived retinal organoids.

STAR protocols

Li YP,Deng WL,Jin ZB

Fri Jun 18 00:00:00 EDT 2021

Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.

Molecules and cells

Hong JJ,Kim KE,Park SY,Bok J,Seo JT,Moon SJ

Tue Aug 31 00:00:00 EDT 2021

Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles.

Nature communications

Volz AK,Frei A,Kretschmer V,de Jesus Domingues AM,Ketting RF,Ueffing M,Boldt K,Krämer-Albers EM,May-Simera HL

Mon Sep 27 00:00:00 EDT 2021

Primary Cilia Mediate TSH-Regulated Thyroglobulin Endocytic Pathways.

Frontiers in endocrinology

Lee J,Sul HJ,Kim KH,Chang JY,Shong M

Fri Feb 11 00:00:00 EST 2022

Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.

Cell reports

Yamakawa D,Katoh D,Kasahara K,Shiromizu T,Matsuyama M,Matsuda C,Maeno Y,Watanabe M,Nishimura Y,Inagaki M

Tue Mar 09 00:00:00 EST 2021

Gene replacement therapy restores RCBTB1 expression and cilium length in patient-derived retinal pigment epithelium.

Journal of cellular and molecular medicine

Huang Z,Zhang D,Chen SC,Jennings L,Carvalho LS,Fletcher S,Chen FK,McLenachan S

Mon Nov 01 00:00:00 EDT 2021

TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.

The Journal of cell biology

Meitinger F,Kong D,Ohta M,Desai A,Oegema K,Loncarek J

Mon Jul 05 00:00:00 EDT 2021

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PloS one

Datta P,Cribbs JT,Seo S

Wed Oct 06 00:00:00 EDT 2021

Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PloS one

Datta P,Cribbs JT,Seo S

Wed Oct 06 00:00:00 EDT 2021

Induction of inverted morphology in brain organoids by vertical-mixing bioreactors.

Communications biology

Suong DNA,Imamura K,Inoue I,Kabai R,Sakamoto S,Okumura T,Kato Y,Kondo T,Yada Y,Klein WL,Watanabe A,Inoue H

Fri Oct 22 00:00:00 EDT 2021

The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.

Neurogastroenterology and motility

Zhou K,Zhou Y,Yang D,Chen T,Liu X,Li S,Wang Z

Wed Sep 01 00:00:00 EDT 2021

Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.

Current biology : CB

Ganga AK,Kennedy MC,Oguchi ME,Gray S,Oliver KE,Knight TA,De La Cruz EM,Homma Y,Fukuda M,Breslow DK

Mon Jul 12 00:00:00 EDT 2021

The 3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase EBP inhibits cholesterylation of Smoothened.

Biochimica et biophysica acta. Molecular and cell biology of lipids

Qiu ZP,Hu A,Song BL

Wed Dec 01 00:00:00 EST 2021

Nonredundant roles of DIAPHs in primary ciliogenesis.

The Journal of biological chemistry

Palander O,Lam A,Collins RF,Moraes TJ,Trimble WS

Fri Aug 20 00:00:00 EDT 2021

Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.

Journal of cell science

Partscht P,Uddin B,Schiebel E

Wed Jan 27 00:00:00 EST 2021

2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells.

Molecules (Basel, Switzerland)

Choi JY,Bae JE,Kim JB,Jo DS,Park NY,Kim YH,Lee HJ,Kim SH,Kim SH,Jeon HB,Na HW,Choi H,Ryu HY,Ryoo ZY,Lee HS,Cho DH

Mon Sep 06 00:00:00 EDT 2021

Biallelic deep intronic variant c.5457+81T>A in TRIP11 causes loss of function and results in achondrogenesis 1A.

Human mutation

Upadhyai P,Radhakrishnan P,Guleria VS,Kausthubham N,Nayak SS,Superti-Furga A,Girisha KM

Sun Aug 01 00:00:00 EDT 2021

Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle.

Scientific reports

Waisman A,Norris AM,Elías Costa M,Kopinke D

Thu Jun 03 00:00:00 EDT 2021

Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hor CHH,Lo JCW,Cham ALS,Leong WY,Goh ELK

Wed Aug 11 00:00:00 EDT 2021

Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Hor CHH,Lo JCW,Cham ALS,Leong WY,Goh ELK

Wed Aug 11 00:00:00 EDT 2021

Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity.

Developmental cell

Xie C,Abrams SR,Herranz-Pérez V,García-Verdugo JM,Reiter JF

Mon Dec 20 00:00:00 EST 2021

Expression of α-Tubulin Acetyltransferase 1 and Tubulin Acetylation as Selective Forces in Cell Competition.

Cells

Rahimi AM,Cai M,Kılı¿ I,Kazerouni ZB,Tapia Contreras C,Hoyer-Fender S

Sun Feb 14 00:00:00 EST 2021

Quantitative Determination of Primary Cilia Protein Distribution Using Immunofluorescence Staining and MATLAB Analysis.

Bio-protocol

Jenks AD,Fivaz M,Tanos BE

Sun Dec 05 00:00:00 EST 2021

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.

Life science alliance

Dhekne HS,Yanatori I,Vides EG,Sobu Y,Diez F,Tonelli F,Pfeffer SR

Sat May 01 00:00:00 EDT 2021

CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.

eLife

Gonçalves AB,Hasselbalch SK,Joensen BB,Patzke S,Martens P,Ohlsen SK,Quinodoz M,Nikopoulos K,Suleiman R,Damsø Jeppesen MP,Weiss C,Christensen ST,Rivolta C,Andersen JS,Farinelli P,Pedersen LB

Wed Jul 14 00:00:00 EDT 2021

Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.

Journal of medicinal chemistry

Zhao F,Wu Y,Zhou F,Xue D,Zhao S,Lu W,Liu X,Hu T,Qiu Y,Li R,Gu T,Xu Y,Xu F,Zhong G,Jiang Z,Zhao S,Tao H

Thu Sep 23 00:00:00 EDT 2021

A ZFYVE19 gene mutation associated with neonatal cholestasis and cilia dysfunction: case report with a novel pathogenic variant.

Orphanet journal of rare diseases

Mandato C,Siano MA,Nazzaro L,Gelzo M,Francalanci P,Rizzo F,D'Agostino Y,Morleo M,Brillante S,Weisz A,Franco B,Vajro P

Wed Apr 14 00:00:00 EDT 2021

iScience

Speight P,Rozycki M,Venugopal S,Szászi K,Kofler M,Kapus A

Fri Jul 23 00:00:00 EDT 2021

iScience

Speight P,Rozycki M,Venugopal S,Szászi K,Kofler M,Kapus A

Fri Jul 23 00:00:00 EDT 2021

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.

PLoS genetics

Rashidieh B,Shohayeb B,Bain AL,Fortuna PRJ,Sinha D,Burgess A,Mills R,Adams RC,Lopez JA,Blumbergs P,Finnie J,Kalimutho M,Piper M,Hudson JE,Ng DCH,Khanna KK

Fri Oct 01 00:00:00 EDT 2021

Cilium induction triggers differentiation of glioma stem cells.

Cell reports

Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J

Tue Sep 07 00:00:00 EDT 2021

Cilium induction triggers differentiation of glioma stem cells.

Cell reports

Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J

Tue Sep 07 00:00:00 EDT 2021

Human brain organoids assemble functionally integrated bilateral optic vesicles.

Cell stem cell

Gabriel E,Albanna W,Pasquini G,Ramani A,Josipovic N,Mariappan A,Schinzel F,Karch CM,Bao G,Gottardo M,Suren AA,Hescheler J,Nagel-Wolfrum K,Persico V,Rizzoli SO,Altmüller J,Riparbelli MG,Callaini G,Goureau O,Papantonis A,Busskamp V,Schneider T,Gopalakrishnan J

Thu Oct 07 00:00:00 EDT 2021

Identification of Cilia in Different Mouse Tissues.

Cells

Li X,Yang S,Deepak V,Chinipardaz Z,Yang S

Tue Jun 29 00:00:00 EDT 2021

Investigating Primary Cilia during Peripheral Nervous System Formation.

International journal of molecular sciences

Yusifov E,Dumoulin A,Stoeckli ET

Sat Mar 20 00:00:00 EDT 2021

Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.

Nature

Willnow D,Benary U,Margineanu A,Vignola ML,Konrath F,Pongrac IM,Karimaddini Z,Vigilante A,Wolf J,Spagnoli FM

Wed Sep 01 00:00:00 EDT 2021

Exocyst complex mediates recycling of internal cilia.

Current biology : CB

Rivera-Molina FE,Xi Z,Reales E,Wang B,Toomre D

Mon Dec 20 00:00:00 EST 2021

Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.

Experimental dermatology

Rizaldy D,Toriyama M,Kato H,Fukui R,Fujita F,Nakamura M,Okada F,Morita A,Ishii KJ

Tue Jun 01 00:00:00 EDT 2021

Disrupted intraflagellar transport due to IFT74 variants causes Joubert syndrome.

Genetics in medicine : official journal of the American College of Medical Genetics

Luo M,Lin Z,Zhu T,Jin M,Meng D,He R,Cao Z,Shen Y,Lu C,Cai R,Zhao Y,Wang X,Li H,Wu S,Zou X,Luo G,Cao L,Huang M,Jiao H,Gao H,Sui R,Zhao C,Ma X,Cao M

Tue Jun 01 00:00:00 EDT 2021

Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.

Frontiers in cell and developmental biology

Bernatik O,Paclikova P,Kotrbova A,Bryja V,Cajanek L

Tue Mar 16 00:00:00 EDT 2021

MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis.

Cancers

Pietrobono S,Franci L,Imperatore F,Zanini C,Stecca B,Chiariello M

Wed Sep 29 00:00:00 EDT 2021

Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.

Molecular biology of the cell

Kobayashi T,Ishida Y,Hirano T,Katoh Y,Nakayama K

Fri Jan 01 00:00:00 EST 2021

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.

Cell death and differentiation

Chen TY,Huang BM,Tang TK,Chao YY,Xiao XY,Lee PR,Yang LY,Wang CY

Tue Jun 01 00:00:00 EDT 2021

Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.

Journal of cell science

Blasius TL,Yue Y,Prasad R,Liu X,Gennerich A,Verhey KJ

Thu Jul 01 00:00:00 EDT 2021

Ciliary Hedgehog signaling regulates cell survival to build the facial midline.

eLife

Abrams SR,Reiter JF

Thu Oct 21 00:00:00 EDT 2021

DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.

Developmental dynamics : an official publication of the American Association of Anatomists

Guo L,Beck T,Fulmer D,Ramos-Ortiz S,Glover J,Wang C,Moore K,Gensemer C,Morningstar J,Moore R,Schott JJ,Le Tourneau T,Koren N,Norris RA

Fri Oct 01 00:00:00 EDT 2021

Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model.

International journal of molecular sciences

Bae JE,Min D,Choi JY,Choi H,Kim JB,Park NY,Jo DS,Kim YH,Na HW,Kim YJ,Kim ES,Kim HJ,Cho DH

Sun Oct 10 00:00:00 EDT 2021

A CRISPR and high-content imaging assay compliant with ACMG/AMP guidelines for clinical variant interpretation in ciliopathies.

Human genetics

Nazlamova L,Thomas NS,Cheung MK,Legebeke J,Lord J,Pengelly RJ,Tapper WJ,Wheway G

Thu Apr 01 00:00:00 EDT 2021

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD.

Diagnostics (Basel, Switzerland)

Ancel J,Belgacemi R,Diabasana Z,Perotin JM,Bonnomet A,Dewolf M,Launois C,Mulette P,Deslée G,Polette M,Dormoy V

Tue Aug 31 00:00:00 EDT 2021

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia.

eLife

Quidwai T,Wang J,Hall EA,Petriman NA,Leng W,Kiesel P,Wells JN,Murphy LC,Keighren MA,Marsh JA,Lorentzen E,Pigino G,Mill P

Thu Nov 04 00:00:00 EDT 2021

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.

eLife

Gopalan J,Omar MH,Roy A,Cruz NM,Falcone J,Jones KN,Forbush KA,Himmelfarb J,Freedman BS,Scott JD

Mon Jul 12 00:00:00 EDT 2021

Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.

Journal of the American Heart Association

Morningstar JE,Gensemer C,Moore R,Fulmer D,Beck TC,Wang C,Moore K,Guo L,Sieg F,Nagata Y,Bertrand P,Spampinato RA,Glover J,Poelzing S,Gourdie RG,Watts K,Richardson WJ,Levine RA,Borger MA,Norris RA

Tue Dec 21 00:00:00 EST 2021

Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.

Journal of the American Heart Association

Morningstar JE,Gensemer C,Moore R,Fulmer D,Beck TC,Wang C,Moore K,Guo L,Sieg F,Nagata Y,Bertrand P,Spampinato RA,Glover J,Poelzing S,Gourdie RG,Watts K,Richardson WJ,Levine RA,Borger MA,Norris RA

Tue Dec 21 00:00:00 EST 2021

Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.

Journal of the American Heart Association

Morningstar JE,Gensemer C,Moore R,Fulmer D,Beck TC,Wang C,Moore K,Guo L,Sieg F,Nagata Y,Bertrand P,Spampinato RA,Glover J,Poelzing S,Gourdie RG,Watts K,Richardson WJ,Levine RA,Borger MA,Norris RA

Tue Dec 21 00:00:00 EST 2021

Mitral Valve Prolapse Induces Regionalized Myocardial Fibrosis.

Journal of the American Heart Association

Morningstar JE,Gensemer C,Moore R,Fulmer D,Beck TC,Wang C,Moore K,Guo L,Sieg F,Nagata Y,Bertrand P,Spampinato RA,Glover J,Poelzing S,Gourdie RG,Watts K,Richardson WJ,Levine RA,Borger MA,Norris RA

Tue Dec 21 00:00:00 EST 2021

Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.

Scientific reports

Cyge B,Voronina V,Hoque M,Kim EN,Hall J,Bailey-Lundberg JM,Pazour GJ,Crawford HC,Moon RT,Li FQ,Takemaru KI

Thu Aug 26 00:00:00 EDT 2021

A ciliopathy complex builds distal appendages to initiate ciliogenesis.

The Journal of cell biology

Kumar D,Rains A,Herranz-Pérez V,Lu Q,Shi X,Swaney DL,Stevenson E,Krogan NJ,Huang B,Westlake C,Garcia-Verdugo JM,Yoder BK,Reiter JF

Mon Sep 06 00:00:00 EDT 2021

Functional inhibition of fatty acid binding protein 4 ameliorates impaired ciliogenesis in GCs.

Biochemical and biophysical research communications

Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

Fri Feb 05 00:00:00 EST 2021

Sub-toxic levels of cobalt ions impair chondrocyte mechanostranduction via HDAC6-dependent primary cilia shortening.

Biochemical and biophysical research communications

Wu H,Wang Z,Liu S,Meng H,Liu S,Fu S

Fri Mar 12 00:00:00 EST 2021

WDR35 is involved in subcellular localization of acetylated tubulin in 293T cells.

Biochemical and biophysical research communications

Sekiguchi T,Ishii T,Kobayashi H,Furuno N

Fri Apr 02 00:00:00 EDT 2021

YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development.

Developmental biology

Lavado A,Gangwar R,Paré J,Wan S,Fan Y,Cao X

Wed Dec 01 00:00:00 EST 2021

Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.

Science advances

Chen C,Xu Q,Zhang Y,Davies BA,Huang Y,Katzmann DJ,Harris PC,Hu J,Ling K

Tue Jun 01 00:00:00 EDT 2021

Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons.

Experimental neurobiology

Kim H,Sim H,Lee JE,Seo MK,Lim J,Bang Y,Nam D,Lee SY,Chung SK,Choi HJ,Park SW,Son I,Kim J,Seol W

Wed Jun 30 00:00:00 EDT 2021

Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress.

Antioxidants (Basel, Switzerland)

Mustafa R,Rawas C,Mannal N,Kreiner G,Spittau B,Kamińska K,Yilmaz R,Pötschke C,Kirsch J,Liss B,Tucker KL,Parlato R

Fri Aug 13 00:00:00 EDT 2021

LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.

Nature communications

Hu HB,Song ZQ,Song GP,Li S,Tu HQ,Wu M,Zhang YC,Yuan JF,Li TT,Li PY,Xu YL,Shen XL,Han QY,Li AL,Zhou T,Chun J,Zhang XM,Li HY

Thu Jan 28 00:00:00 EST 2021

Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity.

Nature communications

Kyrousi C,O'Neill AC,Brazovskaja A,He Z,Kielkowski P,Coquand L,Di Giaimo R,D' Andrea P,Belka A,Forero Echeverry A,Mei D,Lenge M,Cruceanu C,Buchsbaum IY,Khattak S,Fabien G,Binder E,Elmslie F,Guerrini R,Baffet AD,Sieber SA,Treutlein B,Robertson SP,Cappello S

Tue Nov 02 00:00:00 EDT 2021

Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia.

The American journal of pathology

Okamoto H,Muraki I,Okada H,Tomita H,Suzuki K,Takada C,Wakayama Y,Kuroda A,Fukuda H,Kawasaki Y,Nishio A,Matsuo M,Tamaoki Y,Inagawa R,Takashima S,Taniguchi T,Suzuki A,Suzuki K,Miyazaki N,Kakino Y,Yasuda R,Fukuta T,Kitagawa Y,Miyake T,Doi T,Yoshida T,Yoshida S,Ogura S

Wed Sep 01 00:00:00 EDT 2021

BBS Proteins Affect Ciliogenesis and Are Essential for Hedgehog Signaling, but Not for Formation of iPSC-Derived RPE-65 Expressing RPE-Like Cells.

International journal of molecular sciences

Hey CAB,Larsen LJ,Tümer Z,Brøndum-Nielsen K,Grønskov K,Hjortshøj TD,Møller LB

Fri Jan 29 00:00:00 EST 2021

Centriolar Protein C2cd3 Is Required for Craniofacial Development.

Frontiers in cell and developmental biology

Chang CF,Brown KM,Yang Y,Brugmann SA

Sat Jul 16 00:00:00 EDT 2022

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.

Brain : a journal of neurology

Shireman JM,Atashi F,Lee G,Ali ES,Saathoff MR,Park CH,Savchuk S,Baisiwala S,Miska J,Lesniak MS,James CD,Stupp R,Kumthekar P,Horbinski CM,Ben-Sahra I,Ahmed AU

Fri May 07 00:00:00 EDT 2021

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.

Brain : a journal of neurology

Shireman JM,Atashi F,Lee G,Ali ES,Saathoff MR,Park CH,Savchuk S,Baisiwala S,Miska J,Lesniak MS,James CD,Stupp R,Kumthekar P,Horbinski CM,Ben-Sahra I,Ahmed AU

Fri May 07 00:00:00 EDT 2021

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.

Brain : a journal of neurology

Shireman JM,Atashi F,Lee G,Ali ES,Saathoff MR,Park CH,Savchuk S,Baisiwala S,Miska J,Lesniak MS,James CD,Stupp R,Kumthekar P,Horbinski CM,Ben-Sahra I,Ahmed AU

Fri May 07 00:00:00 EDT 2021

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.

Journal of cell science

Grosch M,Brunner K,Ilyaskin AV,Schober M,Staudner T,Schmied D,Stumpp T,Schmidt KN,Madej MG,Pessoa TD,Othmen H,Kubitza M,Osten L,de Vries U,Mair MM,Somlo S,Moser M,Kunzelmann K,Ziegler C,Haerteis S,Korbmacher C,Witzgall R

Sun Aug 15 00:00:00 EDT 2021

Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.

The Journal of pathology

Shinmura K,Kusafuka K,Kawasaki H,Kato H,Hariyama T,Tsuchiya K,Kawanishi Y,Funai K,Misawa K,Mineta H,Sugimura H

Sun Aug 01 00:00:00 EDT 2021

Exovesicular-Shh confers Imatinib resistance by upregulating Bcl2 expression in chronic myeloid leukemia with variant chromosomes.

Cell death & disease

Dalal H,Subramanian S,V P S,Gowda DA,H K,Damodar S,Vyas N

Thu Mar 11 00:00:00 EST 2021

Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.

The EMBO journal

Duan S,Li H,Zhang Y,Yang S,Chen Y,Qiu B,Huang C,Wang J,Li J,Zhu X,Yan X

Fri Jan 15 00:00:00 EST 2021

Rabl2 GTP hydrolysis licenses BBSome-mediated export to fine-tune ciliary signaling.

The EMBO journal

Duan S,Li H,Zhang Y,Yang S,Chen Y,Qiu B,Huang C,Wang J,Li J,Zhu X,Yan X

Fri Jan 15 00:00:00 EST 2021

Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis.

Nature communications

Kwon OS,Mishra R,Safieddine A,Coleno E,Alasseur Q,Faucourt M,Barbosa I,Bertrand E,Spassky N,Le Hir H

Mon Mar 01 00:00:00 EST 2021

Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis.

Journal of lipid research

Tripathi P,Zhu Z,Qin H,Elsherbini A,Crivelli SM,Roush E,Wang G,Spassieva SD,Bieberich E

Thu Mar 10 00:00:00 EST 2022

Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia.

Scientific reports

Kim J,Choi H,Choi DH,Park K,Kim HJ,Park M

Tue Jan 26 00:00:00 EST 2021

Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.

Biology open

Qiu H,Fujisawa S,Nozaki S,Katoh Y,Nakayama K

Mon Jan 25 00:00:00 EST 2021

Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells.

Cells

Qatato M,Venugopalan V,Al-Hashimi A,Rehders M,Valentine AD,Hein Z,Dallto U,Springer S,Brix K

Wed Jun 16 00:00:00 EDT 2021

TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection.

Thorax

Pearson H,Todd EJAA,Ahrends M,Hover SE,Whitehouse A,Stacey M,Lippiat JD,Wilkens L,Fieguth HG,Danov O,Hesse C,Barr JN,Mankouri J

Fri Jan 01 00:00:00 EST 2021

Rab34 is necessary for early stages of intracellular ciliogenesis.

Current biology : CB

Stuck MW,Chong WM,Liao JC,Pazour GJ

Mon Jul 12 00:00:00 EDT 2021

DAB2IP modulates primary cilia formation associated with renal tumorigenesis.

Neoplasia (New York, N.Y.)

Lin CJ,Dang A,Hernandez E,Hsieh JT

Fri Jan 01 00:00:00 EST 2021

Deletion of Sox9 in the liver leads to hepatic cystogenesis in mice by transcriptionally downregulating Sec63.

The Journal of pathology

Xu WP,Cui YL,Chen LL,Ding K,Ding CH,Chen F,Zhang X,Xie WF

Sat May 01 00:00:00 EDT 2021

Identification of disease-relevant modulators of the SHH pathway in the developing brain.

Development (Cambridge, England)

Mecklenburg N,Kowalczyk I,Witte F,Görne J,Laier A,Mamo TM,Gonschior H,Lehmann M,Richter M,Sporbert A,Purfürst B,Hübner N,Hammes A

Wed Sep 01 00:00:00 EDT 2021

Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion.

Redox biology

Han YK,Kim JS,Lee GB,Lim JH,Park KM

Fri Oct 01 00:00:00 EDT 2021

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.

The EMBO journal

Senatore E,Chiuso F,Rinaldi L,Intartaglia D,Delle Donne R,Pedone E,Catalanotti B,Pirone L,Fiorillo B,Moraca F,Giamundo G,Scala G,Raffeiner A,Torres-Quesada O,Stefan E,Kwiatkowski M,van Pijkeren A,Morleo M,Franco B,Garbi C,Conte I,Feliciello A

Mon May 17 00:00:00 EDT 2021

EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.

Journal of cell science

Partisani M,Baron CL,Ghossoub R,Fayad R,Pagnotta S,Abélanet S,Macia E,Brau F,Lacas-Gervais S,Benmerah A,Luton F,Franco M

Fri Jan 22 00:00:00 EST 2021

EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.

Journal of cell science

Partisani M,Baron CL,Ghossoub R,Fayad R,Pagnotta S,Abélanet S,Macia E,Brau F,Lacas-Gervais S,Benmerah A,Luton F,Franco M

Fri Jan 22 00:00:00 EST 2021

Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function.

Glia

Cullen CL,O'Rourke M,Beasley SJ,Auderset L,Zhen Y,Pepper RE,Gasperini R,Young KM

Sat May 01 00:00:00 EDT 2021

Δ9-Tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development.

Development (Cambridge, England)

Lo HF,Hong M,Szutorisz H,Hurd YL,Krauss RS

Fri Oct 01 00:00:00 EDT 2021

Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone.

Molecular biology of the cell

Wiegering A,Dildrop R,Vesque C,Khanna H,Schneider-Maunoury S,Gerhardt C

Thu Apr 15 00:00:00 EDT 2021

Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.

Cellular signalling

Markiewicz Ł,Uśpieński T,Baran B,Niedziółka SM,Niewiadomski P

Thu Apr 01 00:00:00 EDT 2021

Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.

Scientific reports

Lee J,Park KC,Sul HJ,Hong HJ,Kim KH,Kero J,Shong M

Thu Feb 18 00:00:00 EST 2021

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.

Cancers

Shi P,Hoang-Minh LB,Tian J,Cheng A,Basrai R,Kalaria N,Lebowitz JJ,Khoshbouei H,Deleyrolle LP,Sarkisian MR

Thu Apr 01 00:00:00 EDT 2021

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.

Cancers

Shi P,Hoang-Minh LB,Tian J,Cheng A,Basrai R,Kalaria N,Lebowitz JJ,Khoshbouei H,Deleyrolle LP,Sarkisian MR

Thu Apr 01 00:00:00 EDT 2021

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.

Cancers

Shi P,Hoang-Minh LB,Tian J,Cheng A,Basrai R,Kalaria N,Lebowitz JJ,Khoshbouei H,Deleyrolle LP,Sarkisian MR

Thu Apr 01 00:00:00 EDT 2021

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.

Cancers

Shi P,Hoang-Minh LB,Tian J,Cheng A,Basrai R,Kalaria N,Lebowitz JJ,Khoshbouei H,Deleyrolle LP,Sarkisian MR

Thu Apr 01 00:00:00 EDT 2021

ATXN10 Is Required for Embryonic Heart Development and Maintenance of Epithelial Cell Phenotypes in the Adult Kidney and Pancreas.

Frontiers in cell and developmental biology

Bentley-Ford MR,Andersen RS,Croyle MJ,Haycraft CJ,Clearman KR,Foote JB,Reiter JF,Yoder BK

Fri Oct 20 00:00:00 EDT 2023

Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Han SJ,Kim JI,Lipschutz JH,Park KM

Mon Nov 01 00:00:00 EDT 2021

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

The Journal of cell biology

Zhang YC,Bai YF,Yuan JF,Shen XL,Xu YL,Jian XX,Li S,Song ZQ,Hu HB,Li PY,Tu HQ,Han QY,Wang N,Li AL,Zhang XM,Wu M,Zhou T,Li HY

Mon Feb 01 00:00:00 EST 2021

CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.

The Journal of cell biology

Zhang YC,Bai YF,Yuan JF,Shen XL,Xu YL,Jian XX,Li S,Song ZQ,Hu HB,Li PY,Tu HQ,Han QY,Wang N,Li AL,Zhang XM,Wu M,Zhou T,Li HY

Mon Feb 01 00:00:00 EST 2021

Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress.

Free radical biology & medicine

Han YK,Kim JS,Jang G,Park KM

Wed Dec 01 00:00:00 EST 2021

Identification of a potent antagonist of smoothened in hedgehog signaling.

Cell & bioscience

Fan J,Li H,Kuang L,Zhao Z,He W,Liu C,Wang Y,Cheng SY,Chen W

Tue Mar 02 00:00:00 EST 2021

Loss of Planar Cell Polarity Effector Fuzzy Causes Renal Hypoplasia by Disrupting Several Signaling Pathways.

Journal of developmental biology

Wang IY,Chung CF,Babayeva S,Sogomonian T,Torban E

Thu Dec 23 00:00:00 EST 2021

Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation.

Stem cells international

Fu S,Zhang C,Yan X,Li D,Wang Y,Dong C,Cao Z,Ning Y,Shao C,Yang T

Sat Feb 13 00:00:00 EST 2021

FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.

Cell reports

Zhang Y,Hao J,Tarrago MG,Warner GM,Giorgadze N,Wei Q,Huang Y,He K,Chen C,Peclat TR,White TA,Ling K,Tchkonia T,Kirkland JL,Chini EN,Hu J

Tue Aug 03 00:00:00 EDT 2021

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.

Cell

Cowan CS,Renner M,De Gennaro M,Gross-Scherf B,Goldblum D,Hou Y,Munz M,Rodrigues TM,Krol J,Szikra T,Cuttat R,Waldt A,Papasaikas P,Diggelmann R,Patino-Alvarez CP,Galliker P,Spirig SE,Pavlinic D,Gerber-Hollbach N,Schuierer S,Srdanovic A,Balogh M,Panero R,Kusnyerik A,Szabo A,Stadler MB,Orgül S,Picelli S,Hasler PW,Hierlemann A,Scholl HPN,Roma G,Nigsch F,Roska B

Thu Sep 17 00:00:00 EDT 2020

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.

EMBO molecular medicine

Bosakova M,Abraham SP,Nita A,Hruba E,Buchtova M,Taylor SP,Duran I,Martin J,Svozilova K,Barta T,Varecha M,Balek L,Kohoutek J,Radaszkiewicz T,Pusapati GV,Bryja V,Rush ET,Thiffault I,Nickerson DA,Bamshad MJ,Rohatgi R,Cohn DH,Krakow D,Krejci P

Fri Nov 06 00:00:00 EST 2020

ECE2 regulates neurogenesis and neuronal migration during human cortical development.

EMBO reports

Buchsbaum IY,Kielkowski P,Giorgio G,O'Neill AC,Di Giaimo R,Kyrousi C,Khattak S,Sieber SA,Robertson SP,Cappello S

Wed May 06 00:00:00 EDT 2020

Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa.

Frontiers in cell and developmental biology

Gao ML,Lei XL,Han F,He KW,Jin SQ,Zhang YY,Jin ZB

Mon Sep 28 00:00:00 EDT 2020

Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1.

Frontiers in cell and developmental biology

Zhang C,Li C,Siu GKY,Luo X,Yu S

Mon Sep 28 00:00:00 EDT 2020

CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.

Structure (London, England : 1993)

Ochi T,Quarantotti V,Lin H,Jullien J,Rosa E Silva I,Boselli F,Barnabas DD,Johnson CM,McLaughlin SH,Freund SMV,Blackford AN,Kimata Y,Goldstein RE,Jackson SP,Blundell TL,Dutcher SK,Gergely F,van Breugel M

Tue Jun 02 00:00:00 EDT 2020

DIAPH1 regulates ciliogenesis and trafficking in primary cilia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Palander O,Trimble WS

Tue Dec 01 00:00:00 EST 2020

Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.

Journal of cell science

Mc Fie M,Koneva L,Collins I,Coveney CR,Clube AM,Chanalaris A,Vincent TL,Bezbradica JS,Sansom SN,Wann AKT

Wed Jul 08 00:00:00 EDT 2020

Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.

Human molecular genetics

Gilet JG,Ivanova EL,Trofimova D,Rudolf G,Meziane H,Broix L,Drouot N,Courraud J,Skory V,Voulleminot P,Osipenko M,Bahi-Buisson N,Yalcin B,Birling MC,Hinckelmann MV,Kwok BH,Allingham JS,Chelly J

Fri Mar 27 00:00:00 EDT 2020

The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.

Human molecular genetics

Shohayeb B,Ho U,Yeap YY,Parton RG,Millard SS,Xu Z,Piper M,Ng DCH

Wed Jan 15 00:00:00 EST 2020

An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.

Molecular biology of the cell

Su S,Begum S,Ezratty EJ

Sat Aug 01 00:00:00 EDT 2020

Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.

Neuron

Xing L,Kalebic N,Namba T,Vaid S,Wimberger P,Huttner WB

Wed Dec 23 00:00:00 EST 2020

Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control.

Current biology : CB

Ho EK,Tsai AE,Stearns T

Mon Jul 20 00:00:00 EDT 2020

Primary cilia mediate parathyroid hormone receptor type 1 osteogenic actions in osteocytes and osteoblasts via Gli activation.

Journal of cellular physiology

Martín-Guerrero E,Tirado-Cabrera I,Buendía I,Alonso V,Gortázar AR,Ardura JA

Thu Oct 01 00:00:00 EDT 2020

Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes.

Journal of neuroscience research

La Sala G,Di Pietro C,Matteoni R,Bolasco G,Marazziti D,Tocchini-Valentini GP

Thu Dec 17 00:00:00 EST 2020

MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.

JCI insight

Pottorf TS,Fagan MP,Burkey BF,Cho DJ,Vath JE,Tran PV

Thu Jan 30 00:00:00 EST 2020

Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress.

Biomicrofluidics

Chikamori M,Kimura H,Inagi R,Zhou J,Nangaku M,Fujii T

Wed Jul 01 00:00:00 EDT 2020

Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.

Protein & cell

Li X,Lu Q,Peng Y,Geng F,Shao X,Zhou H,Cao Y,Zhang R

Mon Jun 01 00:00:00 EDT 2020

Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.

The EMBO journal

Miyamoto T,Hosoba K,Itabashi T,Iwane AH,Akutsu SN,Ochiai H,Saito Y,Yamamoto T,Matsuura S

Wed Jun 17 00:00:00 EDT 2020

Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Verschuren EHJ,Rigalli JP,Castenmiller C,Rohrbach MU,Bindels RJM,Peters DJM,Arjona FJ,Hoenderop JGJ

Fri May 01 00:00:00 EDT 2020

mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.

Nature communications

Bonucci M,Kuperwasser N,Barbe S,Koka V,de Villeneuve D,Zhang C,Srivastava N,Jia X,Stokes MP,Bienaimé F,Verkarre V,Lopez JB,Jaulin F,Pontoglio M,Terzi F,Delaval B,Piel M,Pende M

Wed Jun 24 00:00:00 EDT 2020

Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.

Nature communications

Lee CH,Song DK,Park CB,Choi J,Kang GM,Shin SH,Kwon I,Park S,Kim S,Kim JY,Dugu H,Park JW,Choi JH,Min SH,Sohn JW,Kim MS

Fri Nov 13 00:00:00 EST 2020

Characterization of primary cilia features reveal cell-type specific variability in in vitro models of osteogenic and chondrogenic differentiation.

PeerJ

Upadhyai P,Guleria VS,Udupa P

Mon Sep 28 00:00:00 EDT 2020

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wang W,Allard BA,Pottorf TS,Wang HH,Vivian JL,Tran PV

Fri May 01 00:00:00 EDT 2020

The HOPS complex subunit VPS39 controls ciliogenesis through autophagy.

Human molecular genetics

Iaconis D,Crina C,Brillante S,Indrieri A,Morleo M,Franco B

Wed Apr 15 00:00:00 EDT 2020

A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.

Disease models & mechanisms

Abdelhamed Z,Lukacs M,Cindric S,Ali S,Omran H,Stottmann RW

Fri Oct 30 00:00:00 EDT 2020

Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.

Developmental biology

Fulmer D,Toomer KA,Glover J,Guo L,Moore K,Moore R,Stairley R,Gensemer C,Abrol S,Rumph MK,Emetu F,Lipschutz JH,McDowell C,Bian J,Wang C,Beck T,Wessels A,Renault MA,Norris RA

Wed Jul 01 00:00:00 EDT 2020

Loss of Cilia Does Not Slow Liver Disease Progression in Mouse Models of Autosomal Recessive Polycystic Kidney Disease.

Kidney360

Gallagher AR,Somlo S

Thu Sep 24 00:00:00 EDT 2020

Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells.

Frontiers in cell and developmental biology

Townshend RF,Shao Y,Wang S,Cortez CL,Esfahani SN,Spence JR,O'Shea KS,Fu J,Gumucio DL,Taniguchi K

Sat Nov 14 00:00:00 EST 2020

An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.

Scientific reports

Zalenski AA,Majumder S,De K,Venere M

Tue Aug 18 00:00:00 EDT 2020

Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development.

Developmental biology

Terry TT,Cheng T,Mahjoub M,Zong H

Tue Sep 15 00:00:00 EDT 2020

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.

eLife

Bowie E,Goetz SC

Tue Jan 14 00:00:00 EST 2020

Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2.

eLife

Tona Y,Wu DK

Wed Sep 23 00:00:00 EDT 2020

CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation.

EMBO reports

Ki SM,Kim JH,Won SY,Oh SJ,Lee IY,Bae YK,Chung KW,Choi BO,Park B,Choi EJ,Lee JE

Wed Feb 05 00:00:00 EST 2020

The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis.

Bioscience reports

Li ZZ,Zhao WL,Wang GS,Gu NH,Sun F

Fri Jan 31 00:00:00 EST 2020

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.

PLoS biology

Liu P,Dodson M,Fang D,Chapman E,Zhang DD

Sat Feb 01 00:00:00 EST 2020

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.

PLoS biology

Liu P,Dodson M,Fang D,Chapman E,Zhang DD

Sat Feb 01 00:00:00 EST 2020

Sonic hedgehog signalling as a potential endobronchial biomarker in COPD.

Respiratory research

Ancel J,Belgacemi R,Perotin JM,Diabasana Z,Dury S,Dewolf M,Bonnomet A,Lalun N,Birembaut P,Polette M,Deslée G,Dormoy V

Fri Aug 07 00:00:00 EDT 2020

CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.

Frontiers in cell and developmental biology

Kobayashi T,Tanaka K,Mashima Y,Shoda A,Tokuda M,Itoh H

Tue Dec 01 00:00:00 EST 2020

Differentiation of ciliated human midbrain-derived LUHMES neurons.

Journal of cell science

Lauter G,Coschiera A,Yoshihara M,Sugiaman-Trapman D,Ezer S,Sethurathinam S,Katayama S,Kere J,Swoboda P

Mon Nov 09 00:00:00 EST 2020

hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning.

Biology of the cell

Pizon V,Gaudin N,Poteau M,Cifuentes-Diaz C,Demdou R,Heyer V,Reina San Martin B,Azimzadeh J

Wed Jan 01 00:00:00 EST 2020

Nubp2 is required for cranial neural crest survival in the mouse.

Developmental biology

DiStasio A,Paulding D,Chaturvedi P,Stottmann RW

Sat Feb 15 00:00:00 EST 2020

Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.

Human molecular genetics

Flynn M,Whitton L,Donohoe G,Morrison CG,Morris DW

Sat Feb 01 00:00:00 EST 2020

A reduction of primary cilia but not hedgehog signaling disrupts morphogenesis in testicular organoids.

Cell and tissue research

Goldsmith TM,Sakib S,Webster D,Carlson DF,Van der Hoorn F,Dobrinski I

Wed Apr 01 00:00:00 EDT 2020

Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling.

JCI insight

Streets AJ,Prosseda PP,Ong AC

Thu Aug 20 00:00:00 EDT 2020

ARL13B regulates Sonic hedgehog signaling from outside primary cilia.

eLife

Gigante ED,Taylor MR,Ivanova AA,Kahn RA,Caspary T

Wed Mar 04 00:00:00 EST 2020

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.

eLife

Yoshida S,Aoki K,Fujiwara K,Nakakura T,Kawamura A,Yamada K,Ono M,Yogosawa S,Yoshida K

Thu Aug 06 00:00:00 EDT 2020

The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.

eLife

Yoshida S,Aoki K,Fujiwara K,Nakakura T,Kawamura A,Yamada K,Ono M,Yogosawa S,Yoshida K

Thu Aug 06 00:00:00 EDT 2020

Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.

The Journal of biological chemistry

Yamazoe T,Nagai T,Umeda S,Sugaya Y,Mizuno K

Fri Oct 23 00:00:00 EDT 2020

Robust classification of cell cycle phase and biological feature extraction by image-based deep learning.

Molecular biology of the cell

Nagao Y,Sakamoto M,Chinen T,Okada Y,Takao D

Mon Jun 15 00:00:00 EDT 2020

Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome.

Stem cell reports

Lee B,Panda S,Lee HY

Tue Aug 11 00:00:00 EDT 2020

Analysis of Caveolin in Primary Cilia.

Methods in molecular biology (Clifton, N.J.)

Morthorst SK,Mogensen JB,Christensen ST,Pedersen LB

Wed Mar 31 00:00:00 EDT 2021

The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts.

BMC molecular and cell biology

Venugopal N,Ghosh A,Gala H,Aloysius A,Vyas N,Dhawan J

Wed Apr 15 00:00:00 EDT 2020

Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis.

The Journal of cell biology

Viol L,Hata S,Pastor-Peidro A,Neuner A,Murke F,Wuchter P,Ho AD,Giebel B,Pereira G

Mon Mar 02 00:00:00 EST 2020

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.

Acta neuropathologica communications

Findakly S,Choudhury A,Daggubati V,Pekmezci M,Lang UE,Raleigh DR

Mon Jul 20 00:00:00 EDT 2020

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.

Nature communications

Kim Y,Lee J,Seppala M,Cobourne MT,Kim SH

Fri Apr 24 00:00:00 EDT 2020

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.

eLife

Hansen JN,Kaiser F,Klausen C,Stüven B,Chong R,Bönigk W,Mick DU,Möglich A,Jurisch-Yaksi N,Schmidt FI,Wachten D

Wed Jun 24 00:00:00 EDT 2020

Centrosome and ciliary abnormalities in fetal akinesia deformation sequence human fibroblasts.

Scientific reports

Jühlen R,Martinelli V,Vinci C,Breckpot J,Fahrenkrog B

Mon Nov 09 00:00:00 EST 2020

Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.

Journal of cell science

Yu T,Matsuda M

Sun Jun 28 00:00:00 EDT 2020

Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly.

Journal of cell science

Lin YN,Lee YS,Li SK,Tang TK

Wed Jun 24 00:00:00 EDT 2020

Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.

Developmental biology

Archambault D,Cheong A,Iverson E,Tremblay KD,Mager J

Tue Sep 01 00:00:00 EDT 2020

Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.

Science advances

Toro-Tapia G,Das RM

Fri May 01 00:00:00 EDT 2020

PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.

Nature communications

Boukhalfa A,Nascimbeni AC,Ramel D,Dupont N,Hirsch E,Gayral S,Laffargue M,Codogno P,Morel E

Wed Jan 15 00:00:00 EST 2020

Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.

Life science alliance

Gerakopoulos V,Ngo P,Tsiokas L

Tue Sep 01 00:00:00 EDT 2020

Mutations in the exocyst component EXOC2 cause severe defects in human brain development.

The Journal of experimental medicine

Van Bergen NJ,Ahmed SM,Collins F,Cowley M,Vetro A,Dale RC,Hock DH,de Caestecker C,Menezes M,Massey S,Ho G,Pisano T,Glover S,Gusman J,Stroud DA,Dinger M,Guerrini R,Macara IG,Christodoulou J

Mon Oct 05 00:00:00 EDT 2020

CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated α-Tubulin.

The Journal of investigative dermatology

Chiticariu E,Regamey A,Huber M,Hohl D

Wed Jan 01 00:00:00 EST 2020

FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.

Frontiers in cell and developmental biology

Jiang H,Liu S,Cheung MH,Amin A,Liang C

Sat Dec 12 00:00:00 EST 2020

A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells.

Science advances

Dias JM,Alekseenko Z,Jeggari A,Boareto M,Vollmer J,Kozhevnikova M,Wang H,Matise MP,Alexeyenko A,Iber D,Ericson J

Tue Sep 01 00:00:00 EDT 2020

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.

The Journal of biological chemistry

Jászai J,Thamm K,Karbanová J,Janich P,Fargeas CA,Huttner WB,Corbeil D

Fri May 01 00:00:00 EDT 2020

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.

The Journal of biological chemistry

Jászai J,Thamm K,Karbanová J,Janich P,Fargeas CA,Huttner WB,Corbeil D

Fri May 01 00:00:00 EDT 2020

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.

The Journal of biological chemistry

Jászai J,Thamm K,Karbanová J,Janich P,Fargeas CA,Huttner WB,Corbeil D

Fri May 01 00:00:00 EDT 2020

Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.

The Journal of biological chemistry

Jászai J,Thamm K,Karbanová J,Janich P,Fargeas CA,Huttner WB,Corbeil D

Fri May 01 00:00:00 EDT 2020

Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.

Developmental cell

Nguyen QPH,Liu Z,Albulescu A,Ouyang H,Zlock L,Coyaud E,Laurent E,Finkbeiner W,Moraes TJ,Raught B,Mennella V

Mon Oct 26 00:00:00 EDT 2020

TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.

Nature communications

Yan H,Chen C,Chen H,Hong H,Huang Y,Ling K,Hu J,Wei Q

Mon May 04 00:00:00 EDT 2020

A novel CDK-independent function of p27^Kip1 in preciliary vesicle trafficking during ciliogenesis.

Biochemical and biophysical research communications

Yukimoto H,Miyamoto T,Kiyono T,Wang S,Matsuura S,Mizoguchi A,Katayama N,Inagaki M,Kasahara K

Tue Jun 30 00:00:00 EDT 2020

Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles.

BMC nephrology

Molinari E,Srivastava S,Dewhurst RM,Sayer JA

Thu Oct 15 00:00:00 EDT 2020

Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.

EBioMedicine

Belgacemi R,Luczka E,Ancel J,Diabasana Z,Perotin JM,Germain A,Lalun N,Birembaut P,Dubernard X,Mérol JC,Delepine G,Polette M,Deslée G,Dormoy V

Wed Jan 01 00:00:00 EST 2020

Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy.

Cells

Wang EJ,Gailey CD,Brautigan DL,Fu Z

Thu Mar 12 00:00:00 EDT 2020

Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.

The Journal of cell biology

Desai PB,Stuck MW,Lv B,Pazour GJ

Mon Jul 06 00:00:00 EDT 2020

Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.

Disease models & mechanisms

Bangs FK,Miller P,O'Neill E

Thu Jul 30 00:00:00 EDT 2020

LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.

Human molecular genetics

Christ A,Marczenke M,Willnow TE

Wed Nov 25 00:00:00 EST 2020

Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development.

Cerebral cortex (New York, N.Y. : 1991)

Kullmann JA,Meyer S,Pipicelli F,Kyrousi C,Schneider F,Bartels N,Cappello S,Rust MB

Mon May 18 00:00:00 EDT 2020

Intraflagellar-transport A dysfunction causes hyperphagia-induced systemic insulin resistance in a pre-obese state.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jacobs DT,Allard BA,Pottorf TS,Silva LM,Wang W,Al-Naamani A,Agborbesong E,Wang T,Carr DA,Tran PV

Wed Jan 01 00:00:00 EST 2020

ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jung E,Choi TI,Lee JE,Kim CH,Kim J

Wed Jan 01 00:00:00 EST 2020

Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.

The EMBO journal

Singer D,Thamm K,Zhuang H,Karbanová J,Gao Y,Walker JV,Jin H,Wu X,Coveney CR,Marangoni P,Lu D,Grayson PRC,Gulsen T,Liu KJ,Ardu S,Wann AK,Luo S,Zambon AC,Jetten AM,Tredwin C,Klein OD,Attanasio M,Carmeliet P,Huttner WB,Corbeil D,Hu B

Tue Jan 15 00:00:00 EST 2019

Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs.

Clinical cancer research : an official journal of the American Association for Cancer Research

Kiseleva AA,Korobeynikov VA,Nikonova AS,Zhang P,Makhov P,Deneka AY,Einarson MB,Serebriiskii IG,Liu H,Peterson JR,Golemis EA

Mon Jul 01 00:00:00 EDT 2019

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.

Proceedings of the National Academy of Sciences of the United States of America

Kunova Bosakova M,Nita A,Gregor T,Varecha M,Gudernova I,Fafilek B,Barta T,Basheer N,Abraham SP,Balek L,Tomanova M,Fialova Kucerova J,Bosak J,Potesil D,Zieba J,Song J,Konik P,Park S,Duran I,Zdrahal Z,Smajs D,Jansen G,Fu Z,Ko HW,Hampl A,Trantirek L,Krakow D,Krejci P

Tue Mar 05 00:00:00 EST 2019

Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.

Cellular and molecular life sciences : CMLS

Patnaik SR,Kretschmer V,Brücker L,Schneider S,Volz AK,Oancea-Castillo LDR,May-Simera HL

Fri Feb 01 00:00:00 EST 2019

Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.

Cellular and molecular life sciences : CMLS

Patnaik SR,Kretschmer V,Brücker L,Schneider S,Volz AK,Oancea-Castillo LDR,May-Simera HL

Fri Feb 01 00:00:00 EST 2019

Indian Hedgehog links obesity to development of hepatocellular carcinoma.

Oncogene

Chong YC,Lim TE,Fu Y,Shin EM,Tergaonkar V,Han W

Fri Mar 01 00:00:00 EST 2019

Indian Hedgehog links obesity to development of hepatocellular carcinoma.

Oncogene

Chong YC,Lim TE,Fu Y,Shin EM,Tergaonkar V,Han W

Fri Mar 01 00:00:00 EST 2019

Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants.

Genes & diseases

Kane MS,Diamonstein CJ,Hauser N,Deeken JF,Niederhuber JE,Vilboux T

Fri Mar 01 00:00:00 EST 2019

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines.

Development (Cambridge, England)

Capowski EE,Samimi K,Mayerl SJ,Phillips MJ,Pinilla I,Howden SE,Saha J,Jansen AD,Edwards KL,Jager LD,Barlow K,Valiauga R,Erlichman Z,Hagstrom A,Sinha D,Sluch VM,Chamling X,Zack DJ,Skala MC,Gamm DM

Wed Jan 09 00:00:00 EST 2019

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines.

Development (Cambridge, England)

Capowski EE,Samimi K,Mayerl SJ,Phillips MJ,Pinilla I,Howden SE,Saha J,Jansen AD,Edwards KL,Jager LD,Barlow K,Valiauga R,Erlichman Z,Hagstrom A,Sinha D,Sluch VM,Chamling X,Zack DJ,Skala MC,Gamm DM

Wed Jan 09 00:00:00 EST 2019

Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150^glued.

Journal of cellular physiology

Chen TY,Lien WC,Cheng HL,Kuan TS,Sheu SY,Wang CY

Mon Jul 01 00:00:00 EDT 2019

Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150^glued.

Journal of cellular physiology

Chen TY,Lien WC,Cheng HL,Kuan TS,Sheu SY,Wang CY

Mon Jul 01 00:00:00 EDT 2019

Tubular flow activates magnesium transport in the distal convoluted tubule.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Verschuren EHJ,Hoenderop JGJ,Peters DJM,Arjona FJ,Bindels RJM

Mon Apr 01 00:00:00 EDT 2019

The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling.

Human molecular genetics

Massa F,Tammaro R,Prado MA,Cesana M,Lee BH,Finley D,Franco B,Morleo M

Fri Mar 01 00:00:00 EST 2019

The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling.

Human molecular genetics

Massa F,Tammaro R,Prado MA,Cesana M,Lee BH,Finley D,Franco B,Morleo M

Fri Mar 01 00:00:00 EST 2019

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.

Human molecular genetics

Lara Ordónez AJ,Fernández B,Fdez E,Romo-Lozano M,Madero-Pérez J,Lobbestael E,Baekelandt V,Aiastui A,López de Munaín A,Melrose HL,Civiero L,Hilfiker S

Fri Nov 01 00:00:00 EDT 2019

Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.

Human molecular genetics

Dupont MA,Humbert C,Huber C,Siour Q,Guerrera IC,Jung V,Christensen A,Pouliet A,Garfa-Traoré M,Nitschké P,Injeyan M,Millar K,Chitayat D,Shannon P,Girisha KM,Shukla A,Mechler C,Lorentzen E,Benmerah A,Cormier-Daire V,Jeanpierre C,Saunier S,Delous M

Thu Aug 15 00:00:00 EDT 2019

Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl^-]_i in mouse airway cilia.

Pflugers Archiv : European journal of physiology

Ikeuchi Y,Kogiso H,Hosogi S,Tanaka S,Shimamoto C,Matsumura H,Inui T,Marunaka Y,Nakahari T

Fri Feb 01 00:00:00 EST 2019

Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl^-]_i in mouse airway cilia.

Pflugers Archiv : European journal of physiology

Ikeuchi Y,Kogiso H,Hosogi S,Tanaka S,Shimamoto C,Matsumura H,Inui T,Marunaka Y,Nakahari T

Fri Feb 01 00:00:00 EST 2019

HDAC3 and HDAC8 are required for cilia assembly and elongation.

Biology open

Park SA,Yoo H,Seol JH,Rhee K

Fri Aug 09 00:00:00 EDT 2019

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity.

Respiratory research

Wang G,Lou HH,Salit J,Leopold PL,Driscoll S,Schymeinsky J,Quast K,Visvanathan S,Fine JS,Thomas MJ,Crystal RG

Fri Aug 23 00:00:00 EDT 2019

Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.

eLife

Portal C,Rompolas P,Lwigale P,Iomini C

Tue Dec 17 00:00:00 EST 2019

Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation.

Scientific reports

Shim JW,Territo PR,Simpson S,Watson JC,Jiang L,Riley AA,McCarthy B,Persohn S,Fulkerson D,Blazer-Yost BL

Thu Jan 31 00:00:00 EST 2019

Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression.

Cancer letters

Lim JP,Nair S,Shyamasundar S,Chua PJ,Muniasamy U,Matsumoto K,Gunaratne J,Bay BH

Fri Jun 28 00:00:00 EDT 2019

Ocular Ciliopathies: Genetic and Mechanistic Insights into Developing Therapies.

Current medicinal chemistry

Shivanna M,Anand M,Chakrabarti S,Khanna H

Wed Oct 23 00:00:00 EDT 2019

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.

Oncogenesis

Spiombi E,Angrisani A,Fonte S,De Feudis G,Fabretti F,Cucchi D,Izzo M,Infante P,Miele E,Po A,Di Magno L,Magliozzi R,Guardavaccaro D,Maroder M,Canettieri G,Giannini G,Ferretti E,Gulino A,Di Marcotullio L,Moretti M,De Smaele E

Mon Nov 04 00:00:00 EST 2019

Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury.

Biochimica et biophysica acta. Molecular basis of disease

Cassidy H,Slyne J,Higgins M,Radford R,Conlon PJ,Watson AJ,Ryan MP,McMorrow T,Slattery C

Sun Dec 01 00:00:00 EST 2019

HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.

Neuron

Tang T,Zhang Y,Wang Y,Cai Z,Lu Z,Li L,Huang R,Hagelkruys A,Matthias P,Zhang H,Seiser C,Xie Y

Wed Mar 20 00:00:00 EDT 2019

Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region.

Scientific reports

Izumi H,Li Y,Shibaki M,Mori D,Yasunami M,Sato S,Matsunaga H,Mae T,Kodama K,Kamijo T,Kaneko Y,Nakagawara A

Tue Feb 19 00:00:00 EST 2019

Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.

Scientific reports

Molinari E,Ramsbottom SA,Srivastava S,Booth P,Alkanderi S,McLafferty SM,Devlin LA,White K,Gunay-Aygun M,Miles CG,Sayer JA

Thu Jul 25 00:00:00 EDT 2019

Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.

Scientific reports

Molinari E,Ramsbottom SA,Srivastava S,Booth P,Alkanderi S,McLafferty SM,Devlin LA,White K,Gunay-Aygun M,Miles CG,Sayer JA

Thu Jul 25 00:00:00 EDT 2019

Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.

Osteoarthritis and cartilage

Fu S,Thompson CL,Ali A,Wang W,Chapple JP,Mitchison HM,Beales PL,Wann AKT,Knight MM

Mon Jul 01 00:00:00 EDT 2019

Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.

Frontiers in cell and developmental biology

Pruski M,Hu L,Yang C,Wang Y,Zhang JB,Zhang L,Huang Y,Rajnicek AM,St Clair D,McCaig CD,Lang B,Ding YQ

Thu Oct 01 00:00:00 EDT 2020

Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells.

Scientific reports

Bodle J,Hamouda MS,Cai S,Williams RB,Bernacki SH,Loboa EG

Wed May 29 00:00:00 EDT 2019

Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia.

The Journal of physiology

Wang CY,Tsai PY,Chen TY,Tsai HL,Kuo PL,Su MT

Sat Jun 01 00:00:00 EDT 2019

The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.

Journal of the American Society of Nephrology : JASN

Ignarski M,Rill C,Kaiser RWJ,Kaldirim M,Neuhaus R,Esmaillie R,Li X,Klein C,Bohl K,Petersen M,Frese CK,Höhne M,Atanassov I,Rinschen MM,Höpker K,Schermer B,Benzing T,Dieterich C,Fabretti F,Müller RU

Mon Apr 01 00:00:00 EDT 2019

661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.

Frontiers in genetics

Wheway G,Nazlamova L,Turner D,Cross S

Thu Oct 01 00:00:00 EDT 2020

Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.

Cell death & disease

Bae JE,Kang GM,Min SH,Jo DS,Jung YK,Kim K,Kim MS,Cho DH

Mon Dec 16 00:00:00 EST 2019

Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.

Scientific reports

King CR,A A Quadros AR,Chazeau A,Saarloos I,van der Graaf AJ,Verhage M,Toonen RF

Mon Jun 03 00:00:00 EDT 2019

Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.

Journal of cell science

Khouj EM,Prosser SL,Tada H,Chong WM,Liao JC,Sugasawa K,Morrison CG

Thu Oct 03 00:00:00 EDT 2019

Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs.

Frontiers in molecular neuroscience

Barrell WB,Griffin JN,Harvey JL,Danovi D,Beales P,Grigoriadis AE,Liu KJ

Thu Oct 12 00:00:00 EDT 2023

Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.

Stem cell research & therapy

Ritter A,Kreis NN,Roth S,Friemel A,Jennewein L,Eichbaum C,Solbach C,Louwen F,Yuan J

Wed Aug 14 00:00:00 EDT 2019

Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish.

Communications biology

Maerz LD,Burkhalter MD,Schilpp C,Wittekindt OH,Frick M,Philipp M

Thu Apr 02 00:00:00 EDT 2020

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.

Cell reports

Frikstad KM,Molinari E,Thoresen M,Ramsbottom SA,Hughes F,Letteboer SJF,Gilani S,Schink KO,Stokke T,Geimer S,Pedersen LB,Giles RH,Akhmanova A,Roepman R,Sayer JA,Patzke S

Tue Aug 13 00:00:00 EDT 2019

Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation.

Protoplasma

Fokin Artem I,Zhapparova Olga N,Burakov Anton V,Nadezhdina Elena S

Sun Sep 01 00:00:00 EDT 2019

CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease.

Journal of human genetics

Li P,He Y,Cai G,Xiao F,Yang J,Li Q,Chen X

Tue Jan 01 00:00:00 EST 2019

Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons.

Neurochemical research

Miki D,Kobayashi Y,Okada T,Miyamoto T,Takei N,Sekino Y,Koganezawa N,Shirao T,Saito Y

Mon Jul 01 00:00:00 EDT 2019

microRNAs Regulating Human and Mouse Naïve Pluripotency.

International journal of molecular sciences

Wang Y,Hussein AM,Somasundaram L,Sankar R,Detraux D,Mathieu J,Ruohola-Baker H

Fri Nov 22 00:00:00 EST 2019

Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.

PLoS biology

Mirvis M,Siemers KA,Nelson WJ,Stearns TP

Mon Jul 01 00:00:00 EDT 2019

A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.

Human molecular genetics

Cheong A,Degani R,Tremblay KD,Mager J

Thu Aug 15 00:00:00 EDT 2019

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.

Redox biology

Kong MJ,Bak SH,Han KH,Kim JI,Park JW,Park KM

Tue Jan 01 00:00:00 EST 2019

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.

Redox biology

Kong MJ,Bak SH,Han KH,Kim JI,Park JW,Park KM

Tue Jan 01 00:00:00 EST 2019

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.

Redox biology

Kong MJ,Bak SH,Han KH,Kim JI,Park JW,Park KM

Tue Jan 01 00:00:00 EST 2019

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.

Redox biology

Kong MJ,Bak SH,Han KH,Kim JI,Park JW,Park KM

Tue Jan 01 00:00:00 EST 2019

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.

eLife

Lodge EJ,Santambrogio A,Russell JP,Xekouki P,Jacques TS,Johnson RL,Thavaraj S,Bornstein SR,Andoniadou CL

Tue Mar 26 00:00:00 EDT 2019

Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis.

Annals of neurology

Hong H,Joo K,Park SM,Seo J,Kim MH,Shin E,Cheong HI,Lee JH,Kim J

Mon Jul 01 00:00:00 EDT 2019

Rab7 regulates primary cilia disassembly through cilia excision.

The Journal of cell biology

Wang G,Hu HB,Chang Y,Huang Y,Song ZQ,Zhou SB,Chen L,Zhang YC,Wu M,Tu HQ,Yuan JF,Wang N,Pan X,Li AL,Zhou T,Zhang XM,He K,Li HY

Mon Dec 02 00:00:00 EST 2019

Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes.

Scientific reports

Bae JE,Choi H,Shin DW,Na HW,Park NY,Kim JB,Jo DS,Cho MJ,Lyu JH,Chang JH,Lee EH,Lee TR,Kim HJ,Cho DH

Fri Mar 08 00:00:00 EST 2019

Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.

Cell

Hilgendorf KI,Johnson CT,Mezger A,Rice SL,Norris AM,Demeter J,Greenleaf WJ,Reiter JF,Kopinke D,Jackson PK

Wed Nov 27 00:00:00 EST 2019

Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice.

PLoS genetics

Moye AR,Bedoni N,Cunningham JG,Sanzhaeva U,Tucker ES,Mathers P,Peter VG,Quinodoz M,Paris LP,Coutinho-Santos L,Camacho P,Purcell MG,Winkelmann AC,Foster JA,Pugacheva EN,Rivolta C,Ramamurthy V

Thu Aug 01 00:00:00 EDT 2019

A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.

Cancers

White CL,Jayasekara WSN,Picard D,Chen J,Watkins DN,Cain JE,Remke M,Gough DJ

Fri Nov 01 00:00:00 EDT 2019

CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.

Scientific reports

Tsai JJ,Hsu WB,Liu JH,Chang CW,Tang TK

Mon Apr 15 00:00:00 EDT 2019

Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.

Cells

Oh YS,Wang EJ,Gailey CD,Brautigan DL,Allen BL,Fu Z

Thu Jul 04 00:00:00 EDT 2019

Acute Inhibition of Heterotrimeric Kinesin-2 Function Reveals Mechanisms of Intraflagellar Transport in Mammalian Cilia.

Current biology : CB

Engelke MF,Waas B,Kearns SE,Suber A,Boss A,Allen BL,Verhey KJ

Mon Apr 01 00:00:00 EDT 2019

Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases.

EBioMedicine

Martínez-Hernández R,Serrano-Somavilla A,Ramos-Leví A,Sampedro-Nuñez M,Lens-Pardo A,Muñoz De Nova JL,Triviño JC,González MU,Torné L,Casares-Arias J,Martín-Cófreces NB,Sánchez-Madrid F,Marazuela M

Sun Dec 01 00:00:00 EST 2019

AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31^+/- iPSC-Derived RPE Cells.

Molecular therapy. Methods & clinical development

Brydon EM,Bronstein R,Buskin A,Lako M,Pierce EA,Fernandez-Godino R

Fri Dec 13 00:00:00 EST 2019

The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.

Development (Cambridge, England)

Bhattarai SR,Begum S,Popow R,Ezratty EJ

Fri May 10 00:00:00 EDT 2019

Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland.

Molecules and cells

Lee J,Yi S,Chang JY,Kim JT,Sul HJ,Park KC,Zhu X,Cheng SY,Kero J,Kim J,Shong M

Thu Feb 28 00:00:00 EST 2019

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.

Cell reports

Kluth O,Stadion M,Gottmann P,Aga H,Jähnert M,Scherneck S,Vogel H,Krus U,Seelig A,Ling C,Gerdes J,Schürmann A

Tue Mar 12 00:00:00 EDT 2019

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.

Nature communications

Kim M,Mun H,Sung CO,Cho EJ,Jeon HJ,Chun SM,Jung DJ,Shin TH,Jeong GS,Kim DK,Choi EK,Jeong SY,Taylor AM,Jain S,Meyerson M,Jang SJ

Thu Sep 05 00:00:00 EDT 2019

Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells.

Neuroscience

Jeong B,Kim TH,Kim DS,Shin WH,Lee JR,Kim NS,Lee DY

Mon Jul 15 00:00:00 EDT 2019

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.

Current biology : CB

Gerondopoulos A,Strutt H,Stevenson NL,Sobajima T,Levine TP,Stephens DJ,Strutt D,Barr FA

Mon Oct 07 00:00:00 EDT 2019

Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.

Cell reports

Uzquiano A,Cifuentes-Diaz C,Jabali A,Romero DM,Houllier A,Dingli F,Maillard C,Boland A,Deleuze JF,Loew D,Mancini GMS,Bahi-Buisson N,Ladewig J,Francis F

Tue Aug 06 00:00:00 EDT 2019

Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hu R,Huang W,Liu J,Jin M,Wu Y,Li J,Wang J,Yu Z,Wang H,Cao Y

Mon Apr 01 00:00:00 EDT 2019

Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.

Scientific reports

Conkar D,Bayraktar H,Firat-Karalar EN

Thu Oct 03 00:00:00 EDT 2019

Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.

Scientific reports

Conkar D,Bayraktar H,Firat-Karalar EN

Thu Oct 03 00:00:00 EDT 2019

NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.

Scientific reports

Martin-Hurtado A,Martin-Morales R,Robledinos-Antón N,Blanco R,Palacios-Blanco I,Lastres-Becker I,Cuadrado A,Garcia-Gonzalo FR

Wed Sep 25 00:00:00 EDT 2019

Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.

Protein & cell

Mao H,Tang Z,Li H,Sun B,Tan M,Fan S,Zhu Y,Sun Y

Tue Oct 01 00:00:00 EDT 2019

Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.

Journal of cell science

Muñoz-Estrada J,Ferland RJ

Wed Sep 04 00:00:00 EDT 2019

Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.

Journal of cell science

Muñoz-Estrada J,Ferland RJ

Wed Sep 04 00:00:00 EDT 2019

Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.

Biology open

Nozaki S,Castro Araya RF,Katoh Y,Nakayama K

Tue Sep 17 00:00:00 EDT 2019

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.

Nature

Johnson MB,Sun X,Kodani A,Borges-Monroy R,Girskis KM,Ryu SC,Wang PP,Patel K,Gonzalez DM,Woo YM,Yan Z,Liang B,Smith RS,Chatterjee M,Coman D,Papademetris X,Staib LH,Hyder F,Mandeville JB,Grant PE,Im K,Kwak H,Engelhardt JF,Walsh CA,Bae BI

Sun Apr 01 00:00:00 EDT 2018

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.

Nature

Sun Apr 01 00:00:00 EDT 2018

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy.

Nature

Sánchez-Danés A,Larsimont JC,Liagre M,Muñoz-Couselo E,Lapouge G,Brisebarre A,Dubois C,Suppa M,Sukumaran V,Del Marmol V,Tabernero J,Blanpain C

Mon Oct 01 00:00:00 EDT 2018

A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy.

Nature

Sánchez-Danés A,Larsimont JC,Liagre M,Muñoz-Couselo E,Lapouge G,Brisebarre A,Dubois C,Suppa M,Sukumaran V,Del Marmol V,Tabernero J,Blanpain C

Mon Oct 01 00:00:00 EDT 2018

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Cancer cell

Zingg D,Debbache J,Peña-Hernández R,Antunes AT,Schaefer SM,Cheng PF,Zimmerli D,Haeusel J,Calçada RR,Tuncer E,Zhang Y,Bossart R,Wong KK,Basler K,Dummer R,Santoro R,Levesque MP,Sommer L

Mon Jul 09 00:00:00 EDT 2018

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Cancer cell

Zingg D,Debbache J,Peña-Hernández R,Antunes AT,Schaefer SM,Cheng PF,Zimmerli D,Haeusel J,Calçada RR,Tuncer E,Zhang Y,Bossart R,Wong KK,Basler K,Dummer R,Santoro R,Levesque MP,Sommer L

Mon Jul 09 00:00:00 EDT 2018

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Cancer cell

Zingg D,Debbache J,Peña-Hernández R,Antunes AT,Schaefer SM,Cheng PF,Zimmerli D,Haeusel J,Calçada RR,Tuncer E,Zhang Y,Bossart R,Wong KK,Basler K,Dummer R,Santoro R,Levesque MP,Sommer L

Mon Jul 09 00:00:00 EDT 2018

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.

Kidney international

Wang Q,Cobo-Stark P,Patel V,Somlo S,Han PL,Igarashi P

Thu Feb 01 00:00:00 EST 2018

Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.

Kidney international

Wang Q,Cobo-Stark P,Patel V,Somlo S,Han PL,Igarashi P

Thu Feb 01 00:00:00 EST 2018

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.

Neuron

Tavano S,Taverna E,Kalebic N,Haffner C,Namba T,Dahl A,Wilsch-Bräuninger M,Paridaen JTML,Huttner WB

Wed Mar 21 00:00:00 EDT 2018

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.

Neuron

Tavano S,Taverna E,Kalebic N,Haffner C,Namba T,Dahl A,Wilsch-Bräuninger M,Paridaen JTML,Huttner WB

Wed Mar 21 00:00:00 EDT 2018

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.

Neuron

Park SM,Lim JS,Ramakrishina S,Kim SH,Kim WK,Lee J,Kang HC,Reiter JF,Kim DS,Kim HH,Lee JH

Wed Jul 11 00:00:00 EDT 2018

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.

Neuron

Park SM,Lim JS,Ramakrishina S,Kim SH,Kim WK,Lee J,Kang HC,Reiter JF,Kim DS,Kim HH,Lee JH

Wed Jul 11 00:00:00 EDT 2018

Cell type-specific regulation of ciliary transition zone assembly in vertebrates.

The EMBO journal

Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C

Tue May 15 00:00:00 EDT 2018

Cell type-specific regulation of ciliary transition zone assembly in vertebrates.

The EMBO journal

Wiegering A,Dildrop R,Kalfhues L,Spychala A,Kuschel S,Lier JM,Zobel T,Dahmen S,Leu T,Struchtrup A,Legendre F,Vesque C,Schneider-Maunoury S,Saunier S,Rüther U,Gerhardt C

Tue May 15 00:00:00 EDT 2018

A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

Developmental cell

Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

Mon Nov 19 00:00:00 EST 2018

A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

Developmental cell

Ford MJ,Yeyati PL,Mali GR,Keighren MA,Waddell SH,Mjoseng HK,Douglas AT,Hall EA,Sakaue-Sawano A,Miyawaki A,Meehan RR,Boulter L,Jackson IJ,Mill P,Mort RL

Mon Nov 19 00:00:00 EST 2018

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.

Developmental cell

Stephen LA,ElMaghloob Y,McIlwraith MJ,Yelland T,Castro Sanchez P,Roda-Navarro P,Ismail S

Mon Oct 08 00:00:00 EDT 2018

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.

Developmental cell

Stephen LA,ElMaghloob Y,McIlwraith MJ,Yelland T,Castro Sanchez P,Roda-Navarro P,Ismail S

Mon Oct 08 00:00:00 EDT 2018

Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.

Autophagy

Liu ZQ,Lee JN,Son M,Lim JY,Dutta RK,Maharjan Y,Kwak S,Oh GT,Byun K,Choe SK,Park R

Wed Oct 02 00:00:00 EDT 2019

Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.

Autophagy

Liu ZQ,Lee JN,Son M,Lim JY,Dutta RK,Maharjan Y,Kwak S,Oh GT,Byun K,Choe SK,Park R

Wed Oct 02 00:00:00 EDT 2019

Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.

Proceedings of the National Academy of Sciences of the United States of America

Ramsbottom SA,Molinari E,Srivastava S,Silberman F,Henry C,Alkanderi S,Devlin LA,White K,Steel DH,Saunier S,Miles CG,Sayer JA

Tue Dec 04 00:00:00 EST 2018

Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.

Proceedings of the National Academy of Sciences of the United States of America

Ramsbottom SA,Molinari E,Srivastava S,Silberman F,Henry C,Alkanderi S,Devlin LA,White K,Steel DH,Saunier S,Miles CG,Sayer JA

Tue Dec 04 00:00:00 EST 2018

Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.

Proceedings of the National Academy of Sciences of the United States of America

Ramsbottom SA,Molinari E,Srivastava S,Silberman F,Henry C,Alkanderi S,Devlin LA,White K,Steel DH,Saunier S,Miles CG,Sayer JA

Tue Dec 04 00:00:00 EST 2018

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

Experimental & molecular medicine

Dafinger C,Rinschen MM,Borgal L,Ehrenberg C,Basten SG,Franke M,Höhne M,Rauh M,Göbel H,Bloch W,Wunderlich FT,Peters DJM,Tasche D,Mishra T,Habbig S,Dötsch J,Müller RU,Brüning JC,Persigehl T,Giles RH,Benzing T,Schermer B,Liebau MC

Thu Jun 28 00:00:00 EDT 2018

Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.

Experimental & molecular medicine

Thu Jun 28 00:00:00 EDT 2018

Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.

American journal of human genetics

Bozal-Basterra L,Martín-Ruíz I,Pirone L,Liang Y,Sigurðsson JO,Gonzalez-Santamarta M,Giordano I,Gabicagogeascoa E,de Luca A,Rodríguez JA,Wilkie AOM,Kohlhase J,Eastwood D,Yale C,Olsen JV,Rauchman M,Anderson KV,Sutherland JD,Barrio R

Thu Feb 01 00:00:00 EST 2018

Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.

American journal of human genetics

Thu Feb 01 00:00:00 EST 2018

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

American journal of human genetics

Alkanderi S,Molinari E,Shaheen R,Elmaghloob Y,Stephen LA,Sammut V,Ramsbottom SA,Srivastava S,Cairns G,Edwards N,Rice SJ,Ewida N,Alhashem A,White K,Miles CG,Steel DH,Alkuraya FS,Ismail S,Sayer JA

Thu Oct 04 00:00:00 EDT 2018

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.

American journal of human genetics

Alkanderi S,Molinari E,Shaheen R,Elmaghloob Y,Stephen LA,Sammut V,Ramsbottom SA,Srivastava S,Cairns G,Edwards N,Rice SJ,Ewida N,Alhashem A,White K,Miles CG,Steel DH,Alkuraya FS,Ismail S,Sayer JA

Thu Oct 04 00:00:00 EDT 2018

Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.

EMBO reports

Jeong AL,Ka HI,Han S,Lee S,Lee EW,Soh SJ,Joo HJ,Sumiyasuren B,Park JY,Lim JS,Park JH,Lee MS,Yang Y

Tue May 01 00:00:00 EDT 2018

Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.

EMBO reports

Jeong AL,Ka HI,Han S,Lee S,Lee EW,Soh SJ,Joo HJ,Sumiyasuren B,Park JY,Lim JS,Park JH,Lee MS,Yang Y

Tue May 01 00:00:00 EDT 2018

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.

EMBO reports

Kim YJ,Osborn DP,Lee JY,Araki M,Araki K,Mohun T,Känsäkoski J,Brandstack N,Kim HT,Miralles F,Kim CH,Brown NA,Kim HG,Martinez-Barbera JP,Ataliotis P,Raivio T,Layman LC,Kim SH

Thu Feb 01 00:00:00 EST 2018

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.

EMBO reports

Kim YJ,Osborn DP,Lee JY,Araki M,Araki K,Mohun T,Känsäkoski J,Brandstack N,Kim HT,Miralles F,Kim CH,Brown NA,Kim HG,Martinez-Barbera JP,Ataliotis P,Raivio T,Layman LC,Kim SH

Thu Feb 01 00:00:00 EST 2018

Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.

Oncogene

Lee J,Yi S,Won M,Song YS,Yi HS,Park YJ,Park KC,Kim JT,Chang JY,Lee MJ,Sul HJ,Choi JE,Kim KS,Kero J,Kim J,Shong M

Wed Aug 01 00:00:00 EDT 2018

Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.

Oncogene

Lee J,Yi S,Won M,Song YS,Yi HS,Park YJ,Park KC,Kim JT,Chang JY,Lee MJ,Sul HJ,Choi JE,Kim KS,Kero J,Kim J,Shong M

Wed Aug 01 00:00:00 EDT 2018

Centrobin controls primary ciliogenesis in vertebrates.

The Journal of cell biology

Ogungbenro YA,Tena TC,Gaboriau D,Lalor P,Dockery P,Philipp M,Morrison CG

Mon Apr 02 00:00:00 EDT 2018

Centrobin controls primary ciliogenesis in vertebrates.

The Journal of cell biology

Ogungbenro YA,Tena TC,Gaboriau D,Lalor P,Dockery P,Philipp M,Morrison CG

Mon Apr 02 00:00:00 EDT 2018

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.

The Journal of cell biology

Vion AC,Alt S,Klaus-Bergmann A,Szymborska A,Zheng T,Perovic T,Hammoutene A,Oliveira MB,Bartels-Klein E,Hollfinger I,Rautou PE,Bernabeu MO,Gerhardt H

Mon May 07 00:00:00 EDT 2018

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.

The Journal of cell biology

Vion AC,Alt S,Klaus-Bergmann A,Szymborska A,Zheng T,Perovic T,Hammoutene A,Oliveira MB,Bartels-Klein E,Hollfinger I,Rautou PE,Bernabeu MO,Gerhardt H

Mon May 07 00:00:00 EDT 2018

The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.

The Journal of cell biology

Fernández-Barrera J,Bernabé-Rubio M,Casares-Arias J,Rangel L,Fernández-Martín L,Correas I,Alonso MA

Mon Mar 05 00:00:00 EST 2018

Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa.

Journal of medical genetics

de Bruijn SE,Verbakel SK,de Vrieze E,Kremer H,Cremers FPM,Hoyng CB,van den Born LI,Roosing S

Mon Oct 01 00:00:00 EDT 2018

Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa.

Journal of medical genetics

de Bruijn SE,Verbakel SK,de Vrieze E,Kremer H,Cremers FPM,Hoyng CB,van den Born LI,Roosing S

Mon Oct 01 00:00:00 EDT 2018

Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Coveney CR,Collins I,Mc Fie M,Chanalaris A,Yamamoto K,Wann AKT

Tue Jun 19 00:00:00 EDT 2018

Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Coveney CR,Collins I,Mc Fie M,Chanalaris A,Yamamoto K,Wann AKT

Tue Jun 19 00:00:00 EDT 2018

Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lee SH,Joo K,Jung EJ,Hong H,Seo J,Kim J

Thu Feb 01 00:00:00 EST 2018

Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lee SH,Joo K,Jung EJ,Hong H,Seo J,Kim J

Thu Feb 01 00:00:00 EST 2018

Primary cilia-regulated transcriptome in the renal collecting duct.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mohammed SG,Arjona FJ,Verschuren EHJ,Bakey Z,Alkema W,van Hijum S,Schmidts M,Bindels RJM,Hoenderop JGJ

Sun Jul 01 00:00:00 EDT 2018

Primary cilia-regulated transcriptome in the renal collecting duct.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mohammed SG,Arjona FJ,Verschuren EHJ,Bakey Z,Alkema W,van Hijum S,Schmidts M,Bindels RJM,Hoenderop JGJ

Sun Jul 01 00:00:00 EDT 2018

Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

The American journal of pathology

Shannon ML,Fame RM,Chau KF,Dani N,Calicchio ML,Géléoc GS,Lidov HGW,Alexandrescu S,Lehtinen MK

Fri Jun 01 00:00:00 EDT 2018

Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

The American journal of pathology

Shannon ML,Fame RM,Chau KF,Dani N,Calicchio ML,Géléoc GS,Lidov HGW,Alexandrescu S,Lehtinen MK

Fri Jun 01 00:00:00 EDT 2018

Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.

The American journal of pathology

Shannon ML,Fame RM,Chau KF,Dani N,Calicchio ML,Géléoc GS,Lidov HGW,Alexandrescu S,Lehtinen MK

Fri Jun 01 00:00:00 EDT 2018

Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.

Journal of cell science

Stevenson NL,Bergen DJM,Xu A,Wyatt E,Henry F,McCaughey J,Vuolo L,Hammond CL,Stephens DJ

Fri May 04 00:00:00 EDT 2018

Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.

Journal of cell science

Stevenson NL,Bergen DJM,Xu A,Wyatt E,Henry F,McCaughey J,Vuolo L,Hammond CL,Stephens DJ

Fri May 04 00:00:00 EDT 2018

The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.

Journal of cell science

Revenkova E,Liu Q,Gusella GL,Iomini C

Fri May 04 00:00:00 EDT 2018

The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.

Journal of cell science

Revenkova E,Liu Q,Gusella GL,Iomini C

Fri May 04 00:00:00 EDT 2018

Glucose deprivation induces primary cilium formation through mTORC1 inactivation.

Journal of cell science

Takahashi K,Nagai T,Chiba S,Nakayama K,Mizuno K

Mon Jan 08 00:00:00 EST 2018

Glucose deprivation induces primary cilium formation through mTORC1 inactivation.

Journal of cell science

Takahashi K,Nagai T,Chiba S,Nakayama K,Mizuno K

Mon Jan 08 00:00:00 EST 2018

Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.

Journal of cell science

Nagai T,Mukoyama S,Kagiwada H,Goshima N,Mizuno K

Wed Dec 12 00:00:00 EST 2018

Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.

Journal of cell science

Nagai T,Mukoyama S,Kagiwada H,Goshima N,Mizuno K

Wed Dec 12 00:00:00 EST 2018

LRRC45 contributes to early steps of axoneme extension.

Journal of cell science

Kurtulmus B,Yuan C,Schuy J,Neuner A,Hata S,Kalamakis G,Martin-Villalba A,Pereira G

Thu Sep 20 00:00:00 EDT 2018

LRRC45 contributes to early steps of axoneme extension.

Journal of cell science

Kurtulmus B,Yuan C,Schuy J,Neuner A,Hata S,Kalamakis G,Martin-Villalba A,Pereira G

Thu Sep 20 00:00:00 EDT 2018

LRRC45 contributes to early steps of axoneme extension.

Journal of cell science

Kurtulmus B,Yuan C,Schuy J,Neuner A,Hata S,Kalamakis G,Martin-Villalba A,Pereira G

Thu Sep 20 00:00:00 EDT 2018

Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.

Human molecular genetics

Martin L,Kaci N,Estibals V,Goudin N,Garfa-Traore M,Benoist-Lasselin C,Dambroise E,Legeai-Mallet L

Mon Jan 01 00:00:00 EST 2018

Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.

Human molecular genetics

Martin L,Kaci N,Estibals V,Goudin N,Garfa-Traore M,Benoist-Lasselin C,Dambroise E,Legeai-Mallet L

Mon Jan 01 00:00:00 EST 2018

Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.

Human molecular genetics

Martin L,Kaci N,Estibals V,Goudin N,Garfa-Traore M,Benoist-Lasselin C,Dambroise E,Legeai-Mallet L

Mon Jan 01 00:00:00 EST 2018

Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.

Human molecular genetics

Ryan R,Failler M,Reilly ML,Garfa-Traore M,Delous M,Filhol E,Reboul T,Bole-Feysot C,Nitschké P,Baudouin V,Amselem S,Escudier E,Legendre M,Benmerah A,Saunier S

Mon Jan 15 00:00:00 EST 2018

Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.

Human molecular genetics

Ryan R,Failler M,Reilly ML,Garfa-Traore M,Delous M,Filhol E,Reboul T,Bole-Feysot C,Nitschké P,Baudouin V,Amselem S,Escudier E,Legendre M,Benmerah A,Saunier S

Mon Jan 15 00:00:00 EST 2018

DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.

Human molecular genetics

Hartill VL,van de Hoek G,Patel MP,Little R,Watson CM,Berry IR,Shoemark A,Abdelmottaleb D,Parkes E,Bacchelli C,Szymanska K,Knoers NV,Scambler PJ,Ueffing M,Boldt K,Yates R,Winyard PJ,Adler B,Moya E,Hattingh L,Shenoy A,Hogg C,Sheridan E,Roepman R,Norris D,Mitchison HM,Giles RH,Johnson CA

Thu Feb 01 00:00:00 EST 2018

DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.

Human molecular genetics

Thu Feb 01 00:00:00 EST 2018

Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.

Human molecular genetics

Barny I,Perrault I,Michel C,Soussan M,Goudin N,Rio M,Thomas S,Attié-Bitach T,Hamel C,Dollfus H,Kaplan J,Rozet JM,Gerard X

Wed Aug 01 00:00:00 EDT 2018

Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.

Human molecular genetics

Barny I,Perrault I,Michel C,Soussan M,Goudin N,Rio M,Thomas S,Attié-Bitach T,Hamel C,Dollfus H,Kaplan J,Rozet JM,Gerard X

Wed Aug 01 00:00:00 EDT 2018

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.

Human molecular genetics

Kunova Bosakova M,Varecha M,Hampl M,Duran I,Nita A,Buchtova M,Dosedelova H,Machat R,Xie Y,Ni Z,Martin JH,Chen L,Jansen G,Krakow D,Krejci P

Thu Mar 15 00:00:00 EDT 2018

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.

Human molecular genetics

Kunova Bosakova M,Varecha M,Hampl M,Duran I,Nita A,Buchtova M,Dosedelova H,Machat R,Xie Y,Ni Z,Martin JH,Chen L,Jansen G,Krakow D,Krejci P

Thu Mar 15 00:00:00 EDT 2018

Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.

Human molecular genetics

Broix L,Asselin L,Silva CG,Ivanova EL,Tilly P,Gilet JG,Lebrun N,Jagline H,Muraca G,Saillour Y,Drouot N,Reilly ML,Francis F,Benmerah A,Bahi-Buisson N,Belvindrah R,Nguyen L,Godin JD,Chelly J,Hinckelmann MV

Mon Jan 15 00:00:00 EST 2018

Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.

Human molecular genetics

Mon Jan 15 00:00:00 EST 2018

Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Abdelhamed ZA,Ryan TA,Fuller M,Coulson-Gilmer C,Abdelmottaleb DI,Wang TL,Kaun JC,Wang P,Hutson R,Wilkinson N,Bell SM,Johnson CA

Mon Oct 01 00:00:00 EDT 2018

Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Abdelhamed ZA,Ryan TA,Fuller M,Coulson-Gilmer C,Abdelmottaleb DI,Wang TL,Kaun JC,Wang P,Hutson R,Wilkinson N,Bell SM,Johnson CA

Mon Oct 01 00:00:00 EDT 2018

Autophagy alteration prevents primary cilium disassembly in RPE1 cells.

Biochemical and biophysical research communications

Maharjan Y,Lee JN,Kwak S,Lim H,Dutta RK,Liu ZQ,So HS,Park R

Sat Jun 02 00:00:00 EDT 2018

Autophagy alteration prevents primary cilium disassembly in RPE1 cells.

Biochemical and biophysical research communications

Maharjan Y,Lee JN,Kwak S,Lim H,Dutta RK,Liu ZQ,So HS,Park R

Sat Jun 02 00:00:00 EDT 2018

Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition.

Biochemical and biophysical research communications

Han SJ,Jung JK,Im SS,Lee SR,Jang BC,Park KM,Kim JI

Mon Feb 05 00:00:00 EST 2018

Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition.

Biochemical and biophysical research communications

Han SJ,Jung JK,Im SS,Lee SR,Jang BC,Park KM,Kim JI

Mon Feb 05 00:00:00 EST 2018

Dorsoventral differences in cAMP levels and correlated changes in the subcellular distribution of the PKA catalytic domain, provide further evidence that PKA signaling coordinates dorsoventral patterning of the otocyst.

Development, growth & differentiation

Ohta S,Schoenwolf GC

Sat Sep 01 00:00:00 EDT 2018

Development, growth & differentiation

Ohta S,Schoenwolf GC

Sat Sep 01 00:00:00 EDT 2018

Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain.

Journal of molecular neuroscience : MN

Sipos É,Komoly S,Ács P

Thu Mar 01 00:00:00 EST 2018

Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain.

Journal of molecular neuroscience : MN

Sipos É,Komoly S,Ács P

Thu Mar 01 00:00:00 EST 2018

Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.

Biology open

Takei R,Katoh Y,Nakayama K

Mon Apr 30 00:00:00 EDT 2018

Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.

Biology open

Takei R,Katoh Y,Nakayama K

Mon Apr 30 00:00:00 EDT 2018

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.

Nature communications

Tu HQ,Qin XH,Liu ZB,Song ZQ,Hu HB,Zhang YC,Chang Y,Wu M,Huang Y,Bai YF,Wang G,Han QY,Li AL,Zhou T,Liu F,Zhang XM,Li HY

Tue Dec 11 00:00:00 EST 2018

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.

Nature communications

Tu HQ,Qin XH,Liu ZB,Song ZQ,Hu HB,Zhang YC,Chang Y,Wu M,Huang Y,Bai YF,Wang G,Han QY,Li AL,Zhou T,Liu F,Zhang XM,Li HY

Tue Dec 11 00:00:00 EST 2018

Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.

Cell reports

Jenks AD,Vyse S,Wong JP,Kostaras E,Keller D,Burgoyne T,Shoemark A,Tsalikis A,de la Roche M,Michaelis M,Cinatl J,Huang PH,Tanos BE

Tue Jun 05 00:00:00 EDT 2018

Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.

Cell reports

Jenks AD,Vyse S,Wong JP,Kostaras E,Keller D,Burgoyne T,Shoemark A,Tsalikis A,de la Roche M,Michaelis M,Cinatl J,Huang PH,Tanos BE

Tue Jun 05 00:00:00 EDT 2018

Mutation of FOP/FGFR1OP in mice recapitulates human short rib-polydactyly ciliopathy.

Human molecular genetics

Cabaud O,Roubin R,Comte A,Bascunana V,Sergé A,Sedjaï F,Birnbaum D,Rosnet O,Acquaviva C

Mon Oct 01 00:00:00 EDT 2018

Reconstructing the Human Renal Vascular-Tubular Unit In Vitro.

Advanced healthcare materials

Rayner SG,Phong KT,Xue J,Lih D,Shankland SJ,Kelly EJ,Himmelfarb J,Zheng Y

Sat Dec 01 00:00:00 EST 2018

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Nature communications

Buskin A,Zhu L,Chichagova V,Basu B,Mozaffari-Jovin S,Dolan D,Droop A,Collin J,Bronstein R,Mehrotra S,Farkas M,Hilgen G,White K,Pan KT,Treumann A,Hallam D,Bialas K,Chung G,Mellough C,Ding Y,Krasnogor N,Przyborski S,Zwolinski S,Al-Aama J,Alharthi S,Xu Y,Wheway G,Szymanska K,McKibbin M,Inglehearn CF,Elliott DJ,Lindsay S,Ali RR,Steel DH,Armstrong L,Sernagor E,Urlaub H,Pierce E,Lührmann R,Grellscheid SN,Johnson CA,Lako M

Fri Oct 12 00:00:00 EDT 2018

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Nature communications

Fri Oct 12 00:00:00 EDT 2018

CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.

Molecular & cellular proteomics : MCP

Beyer T,Bolz S,Junger K,Horn N,Moniruzzaman M,Wissinger Y,Ueffing M,Boldt K

Sun Jul 01 00:00:00 EDT 2018

CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.

Molecular & cellular proteomics : MCP

Beyer T,Bolz S,Junger K,Horn N,Moniruzzaman M,Wissinger Y,Ueffing M,Boldt K

Sun Jul 01 00:00:00 EDT 2018

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.

Cell reports

May-Simera HL,Wan Q,Jha BS,Hartford J,Khristov V,Dejene R,Chang J,Patnaik S,Lu Q,Banerjee P,Silver J,Insinna-Kettenhofen C,Patel D,Lotfi M,Malicdan M,Hotaling N,Maminishkis A,Sridharan R,Brooks B,Miyagishima K,Gunay-Aygun M,Pal R,Westlake C,Miller S,Sharma R,Bharti K

Tue Jan 02 00:00:00 EST 2018

Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.

Cell reports

Tue Jan 02 00:00:00 EST 2018

Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.

Nature communications

Vuong LT,Iomini C,Balmer S,Esposito D,Aaronson SA,Mlodzik M

Thu Dec 13 00:00:00 EST 2018

Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.

Nature communications

Vuong LT,Iomini C,Balmer S,Esposito D,Aaronson SA,Mlodzik M

Thu Dec 13 00:00:00 EST 2018

M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.

Nature communications

Huang N,Zhang D,Li F,Chai P,Wang S,Teng J,Chen J

Tue Oct 30 00:00:00 EDT 2018

Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice.

Cell death & disease

Wang B,Zhang Y,Dong H,Gong S,Wei B,Luo M,Wang H,Wu X,Liu W,Xu X,Zheng Y,Sun M

Tue May 01 00:00:00 EDT 2018

Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice.

Cell death & disease

Wang B,Zhang Y,Dong H,Gong S,Wei B,Luo M,Wang H,Wu X,Liu W,Xu X,Zheng Y,Sun M

Tue May 01 00:00:00 EDT 2018

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.

eLife

Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ

Tue Oct 16 00:00:00 EDT 2018

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.

eLife

Vuolo L,Stevenson NL,Heesom KJ,Stephens DJ

Tue Oct 16 00:00:00 EDT 2018

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.

Brain structure & function

Ehrlich AT,Semache M,Bailly J,Wojcik S,Arefin TM,Colley C,Le Gouill C,Gross F,Lukasheva V,Hogue M,Darcq E,Harsan LA,Bouvier M,Kieffer BL

Sun Apr 01 00:00:00 EDT 2018

A distal centriolar protein network controls organelle maturation and asymmetry.

Nature communications

Wang L,Failler M,Fu W,Dynlacht BD

Wed Sep 26 00:00:00 EDT 2018

A distal centriolar protein network controls organelle maturation and asymmetry.

Nature communications

Wang L,Failler M,Fu W,Dynlacht BD

Wed Sep 26 00:00:00 EDT 2018

A distal centriolar protein network controls organelle maturation and asymmetry.

Nature communications

Wang L,Failler M,Fu W,Dynlacht BD

Wed Sep 26 00:00:00 EDT 2018

A distal centriolar protein network controls organelle maturation and asymmetry.

Nature communications

Wang L,Failler M,Fu W,Dynlacht BD

Wed Sep 26 00:00:00 EDT 2018

Adenylyl cyclases and TRPV4 mediate Ca²⁺/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes.

Journal of molecular biochemistry

Moore ER,Ryu HS,Zhu YX,Jacobs CR

Thu Oct 01 00:00:00 EDT 2020

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.

Nature communications

He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J

Fri Aug 17 00:00:00 EDT 2018

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.

Nature communications

He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J

Fri Aug 17 00:00:00 EDT 2018

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.

Nature communications

He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J

Fri Aug 17 00:00:00 EDT 2018

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.

Nature communications

He K,Ma X,Xu T,Li Y,Hodge A,Zhang Q,Torline J,Huang Y,Zhao J,Ling K,Hu J

Fri Aug 17 00:00:00 EDT 2018

Membrane association and remodeling by intraflagellar transport protein IFT172.

Nature communications

Wang Q,Taschner M,Ganzinger KA,Kelley C,Villasenor A,Heymann M,Schwille P,Lorentzen E,Mizuno N

Thu Nov 08 00:00:00 EST 2018

Membrane association and remodeling by intraflagellar transport protein IFT172.

Nature communications

Wang Q,Taschner M,Ganzinger KA,Kelley C,Villasenor A,Heymann M,Schwille P,Lorentzen E,Mizuno N

Thu Nov 08 00:00:00 EST 2018

Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.

Cilia

Hoang-Minh LB,Dutra-Clarke M,Breunig JJ,Sarkisian MR

Fri Apr 08 00:00:00 EDT 2022

Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.

Cilia

Hoang-Minh LB,Dutra-Clarke M,Breunig JJ,Sarkisian MR

Fri Apr 08 00:00:00 EDT 2022

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.

Cell reports

Canning P,Park K,Gonçalves J,Li C,Howard CJ,Sharpe TD,Holt LJ,Pelletier L,Bullock AN,Leroux MR

Tue Jan 23 00:00:00 EST 2018

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.

Cell reports

Canning P,Park K,Gonçalves J,Li C,Howard CJ,Sharpe TD,Holt LJ,Pelletier L,Bullock AN,Leroux MR

Tue Jan 23 00:00:00 EST 2018

Guided self-organization and cortical plate formation in human brain organoids.

Nature biotechnology

Lancaster MA,Corsini NS,Wolfinger S,Gustafson EH,Phillips AW,Burkard TR,Otani T,Livesey FJ,Knoblich JA

Sat Jul 01 00:00:00 EDT 2017

Guided self-organization and cortical plate formation in human brain organoids.

Nature biotechnology

Lancaster MA,Corsini NS,Wolfinger S,Gustafson EH,Phillips AW,Burkard TR,Otani T,Livesey FJ,Knoblich JA

Sat Jul 01 00:00:00 EDT 2017

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Cell

Phua SC,Chiba S,Suzuki M,Su E,Roberson EC,Pusapati GV,Schurmans S,Setou M,Rohatgi R,Reiter JF,Ikegami K,Inoue T

Thu Jan 12 00:00:00 EST 2017

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Cell

Phua SC,Chiba S,Suzuki M,Su E,Roberson EC,Pusapati GV,Schurmans S,Setou M,Rohatgi R,Reiter JF,Ikegami K,Inoue T

Thu Jan 12 00:00:00 EST 2017

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Cell

Phua SC,Chiba S,Suzuki M,Su E,Roberson EC,Pusapati GV,Schurmans S,Setou M,Rohatgi R,Reiter JF,Ikegami K,Inoue T

Thu Jan 12 00:00:00 EST 2017

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.

Cell

Phua SC,Chiba S,Suzuki M,Su E,Roberson EC,Pusapati GV,Schurmans S,Setou M,Rohatgi R,Reiter JF,Ikegami K,Inoue T

Thu Jan 12 00:00:00 EST 2017

Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis.

Cell

Kopinke D,Roberson EC,Reiter JF

Thu Jul 13 00:00:00 EDT 2017

Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis.

Cell

Kopinke D,Roberson EC,Reiter JF

Thu Jul 13 00:00:00 EDT 2017

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Nature genetics

Lu H,Galeano MCR,Ott E,Kaeslin G,Kausalya PJ,Kramer C,Ortiz-Brüchle N,Hilger N,Metzis V,Hiersche M,Tay SY,Tunningley R,Vij S,Courtney AD,Whittle B,Wühl E,Vester U,Hartleben B,Neuber S,Frank V,Little MH,Epting D,Papathanasiou P,Perkins AC,Wright GD,Hunziker W,Gee HY,Otto EA,Zerres K,Hildebrandt F,Roy S,Wicking C,Bergmann C

Sat Jul 01 00:00:00 EDT 2017

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Nature genetics

Sat Jul 01 00:00:00 EDT 2017

The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.

Developmental cell

Kanie T,Abbott KL,Mooney NA,Plowey ED,Demeter J,Jackson PK

Mon Jul 10 00:00:00 EDT 2017

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.

Developmental cell

Sigg MA,Menchen T,Lee C,Johnson J,Jungnickel MK,Choksi SP,Garcia G,Busengdal H,Dougherty GW,Pennekamp P,Werner C,Rentzsch F,Florman HM,Krogan N,Wallingford JB,Omran H,Reiter JF

Mon Dec 18 00:00:00 EST 2017

Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.

Developmental cell

Sigg MA,Menchen T,Lee C,Johnson J,Jungnickel MK,Choksi SP,Garcia G,Busengdal H,Dougherty GW,Pennekamp P,Werner C,Rentzsch F,Florman HM,Krogan N,Wallingford JB,Omran H,Reiter JF

Mon Dec 18 00:00:00 EST 2017

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.

American journal of human genetics

Windpassinger C,Piard J,Bonnard C,Alfadhel M,Lim S,Bisteau X,Blouin S,Ali NB,Ng AYJ,Lu H,Tohari S,Talib SZA,van Hul N,Caldez MJ,Van Maldergem L,Yigit G,Kayserili H,Youssef SA,Coppola V,de Bruin A,Tessarollo L,Choi H,Rupp V,Roetzer K,Roschger P,Klaushofer K,Altmüller J,Roy S,Venkatesh B,Ganger R,Grill F,Ben Chehida F,Wollnik B,Altunoglu U,Al Kaissi A,Reversade B,Kaldis P

Thu Sep 07 00:00:00 EDT 2017

CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.

American journal of human genetics

Thu Sep 07 00:00:00 EDT 2017

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

EMBO reports

Kohli P,Höhne M,Jüngst C,Bertsch S,Ebert LK,Schauss AC,Benzing T,Rinschen MM,Schermer B

Fri Sep 01 00:00:00 EDT 2017

The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.

EMBO reports

Kohli P,Höhne M,Jüngst C,Bertsch S,Ebert LK,Schauss AC,Benzing T,Rinschen MM,Schermer B

Fri Sep 01 00:00:00 EDT 2017

HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.

EMBO reports

Kobayashi T,Nakazono K,Tokuda M,Mashima Y,Dynlacht BD,Itoh H

Wed Feb 01 00:00:00 EST 2017

HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.

EMBO reports

Kobayashi T,Nakazono K,Tokuda M,Mashima Y,Dynlacht BD,Itoh H

Wed Feb 01 00:00:00 EST 2017

An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.

The Journal of cell biology

Taniguchi K,Shao Y,Townshend RF,Cortez CL,Harris CE,Meshinchi S,Kalantry S,Fu J,O'Shea KS,Gumucio DL

Mon Dec 04 00:00:00 EST 2017

An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.

The Journal of cell biology

Taniguchi K,Shao Y,Townshend RF,Cortez CL,Harris CE,Meshinchi S,Kalantry S,Fu J,O'Shea KS,Gumucio DL

Mon Dec 04 00:00:00 EST 2017

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.

The Journal of cell biology

Yeyati PL,Schiller R,Mali G,Kasioulis I,Kawamura A,Adams IR,Playfoot C,Gilbert N,van Heyningen V,Wills J,von Kriegsheim A,Finch A,Sakai J,Schofield CJ,Jackson IJ,Mill P

Mon Apr 03 00:00:00 EDT 2017

KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.

The Journal of cell biology

Yeyati PL,Schiller R,Mali G,Kasioulis I,Kawamura A,Adams IR,Playfoot C,Gilbert N,van Heyningen V,Wills J,von Kriegsheim A,Finch A,Sakai J,Schofield CJ,Jackson IJ,Mill P

Mon Apr 03 00:00:00 EDT 2017

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.

Neurobiology of disease

Giddens MM,Wong JC,Schroeder JP,Farrow EG,Smith BM,Owino S,Soden SE,Meyer RC,Saunders C,LePichon JB,Weinshenker D,Escayg A,Hall RA

Sun Oct 01 00:00:00 EDT 2017

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.

Neurobiology of disease

Giddens MM,Wong JC,Schroeder JP,Farrow EG,Smith BM,Owino S,Soden SE,Meyer RC,Saunders C,LePichon JB,Weinshenker D,Escayg A,Hall RA

Sun Oct 01 00:00:00 EDT 2017

Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.

Journal of cellular physiology

Wang CY,Tsai HL,Syu JS,Chen TY,Su MT

Thu Jun 01 00:00:00 EDT 2017

Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.

Journal of cellular physiology

Wang CY,Tsai HL,Syu JS,Chen TY,Su MT

Thu Jun 01 00:00:00 EDT 2017

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.

Journal of cellular physiology

Thorpe SD,Gambassi S,Thompson CL,Chandrakumar C,Santucci A,Knight MM

Fri Sep 01 00:00:00 EDT 2017

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.

Journal of cellular physiology

Thorpe SD,Gambassi S,Thompson CL,Chandrakumar C,Santucci A,Knight MM

Fri Sep 01 00:00:00 EDT 2017

A novel role for primary cilia in airway remodeling.

American journal of physiology. Lung cellular and molecular physiology

Trempus CS,Song W,Lazrak A,Yu Z,Creighton JR,Young BM,Heise RL,Yu YR,Ingram JL,Tighe RM,Matalon S,Garantziotis S

Tue Aug 01 00:00:00 EDT 2017

A novel role for primary cilia in airway remodeling.

American journal of physiology. Lung cellular and molecular physiology

Trempus CS,Song W,Lazrak A,Yu Z,Creighton JR,Young BM,Heise RL,Yu YR,Ingram JL,Tighe RM,Matalon S,Garantziotis S

Tue Aug 01 00:00:00 EDT 2017

Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.

Journal of medical genetics

Nguyen TT,Hull S,Roepman R,van den Born LI,Oud MM,de Vrieze E,Hetterschijt L,Letteboer SJF,van Beersum SEC,Blokland EA,Yntema HG,Cremers FPM,van der Zwaag PA,Arno G,van Wijk E,Webster AR,Haer-Wigman L

Fri Sep 01 00:00:00 EDT 2017

Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.

Journal of medical genetics

Fri Sep 01 00:00:00 EDT 2017

Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency.

Human genetics

Stephen J,Vilboux T,Mian L,Kuptanon C,Sinclair CM,Yildirimli D,Maynard DM,Bryant J,Fischer R,Vemulapalli M,Mullikin JC,Huizing M,Gahl WA,Malicdan MCV,Gunay-Aygun M

Sat Apr 01 00:00:00 EDT 2017

Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency.

Human genetics

Stephen J,Vilboux T,Mian L,Kuptanon C,Sinclair CM,Yildirimli D,Maynard DM,Bryant J,Fischer R,Vemulapalli M,Mullikin JC,Huizing M,Gahl WA,Malicdan MCV,Gunay-Aygun M

Sat Apr 01 00:00:00 EDT 2017

Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Toriyama M,Toriyama M,Wallingford JB,Finnell RH

Tue Aug 01 00:00:00 EDT 2017

Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Toriyama M,Toriyama M,Wallingford JB,Finnell RH

Tue Aug 01 00:00:00 EDT 2017

Estrogen receptor α is required for oviductal transport of embryos.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li S,O'Neill SR,Zhang Y,Holtzman MJ,Takemaru KI,Korach KS,Winuthayanon W

Sat Apr 01 00:00:00 EDT 2017

Estrogen receptor α is required for oviductal transport of embryos.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li S,O'Neill SR,Zhang Y,Holtzman MJ,Takemaru KI,Korach KS,Winuthayanon W

Sat Apr 01 00:00:00 EDT 2017

A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.

European journal of human genetics : EJHG

Rafiullah R,Long AB,Ivanova AA,Ali H,Berkel S,Mustafa G,Paramasivam N,Schlesner M,Wiemann S,Wade RC,Bolthauser E,Blum M,Kahn RA,Caspary T,Rappold GA

Fri Dec 01 00:00:00 EST 2017

A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.

European journal of human genetics : EJHG

Rafiullah R,Long AB,Ivanova AA,Ali H,Berkel S,Mustafa G,Paramasivam N,Schlesner M,Wiemann S,Wade RC,Bolthauser E,Blum M,Kahn RA,Caspary T,Rappold GA

Fri Dec 01 00:00:00 EST 2017

Loss of OCRL increases ciliary PI(4,5)P₂ in Lowe oculocerebrorenal syndrome.

Journal of cell science

Prosseda PP,Luo N,Wang B,Alvarado JA,Hu Y,Sun Y

Sun Oct 15 00:00:00 EDT 2017

Loss of OCRL increases ciliary PI(4,5)P₂ in Lowe oculocerebrorenal syndrome.

Journal of cell science

Prosseda PP,Luo N,Wang B,Alvarado JA,Hu Y,Sun Y

Sun Oct 15 00:00:00 EDT 2017

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

Journal of cell science

Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K

Wed Feb 01 00:00:00 EST 2017

Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

Journal of cell science

Nozaki S,Katoh Y,Terada M,Michisaka S,Funabashi T,Takahashi S,Kontani K,Nakayama K

Wed Feb 01 00:00:00 EST 2017

A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.

Human molecular genetics

Srivastava S,Ramsbottom SA,Molinari E,Alkanderi S,Filby A,White K,Henry C,Saunier S,Miles CG,Sayer JA

Fri Dec 01 00:00:00 EST 2017

A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.

Human molecular genetics

Srivastava S,Ramsbottom SA,Molinari E,Alkanderi S,Filby A,White K,Henry C,Saunier S,Miles CG,Sayer JA

Fri Dec 01 00:00:00 EST 2017

Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.

Genetics

Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

Fri Dec 01 00:00:00 EST 2017

Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.

Genetics

Kazatskaya A,Kuhns S,Lambacher NJ,Kennedy JE,Brear AG,McManus GJ,Sengupta P,Blacque OE

Fri Dec 01 00:00:00 EST 2017

Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.

Stem cells and development

Vestergaard ML,Grubb S,Koefoed K,Anderson-Jenkins Z,Grunnet-Lauridsen K,Calloe K,Clausen C,Christensen ST,Møllgård K,Andersen CY

Wed Nov 01 00:00:00 EDT 2017

Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.

Stem cells and development

Vestergaard ML,Grubb S,Koefoed K,Anderson-Jenkins Z,Grunnet-Lauridsen K,Calloe K,Clausen C,Christensen ST,Møllgård K,Andersen CY

Wed Nov 01 00:00:00 EDT 2017

Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.

Stem cells and development

Vestergaard ML,Grubb S,Koefoed K,Anderson-Jenkins Z,Grunnet-Lauridsen K,Calloe K,Clausen C,Christensen ST,Møllgård K,Andersen CY

Wed Nov 01 00:00:00 EDT 2017

Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.

Cellular and molecular neurobiology

Di Pietro C,Marazziti D,La Sala G,Abbaszadeh Z,Golini E,Matteoni R,Tocchini-Valentini GP

Sun Jan 01 00:00:00 EST 2017

Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.

Cellular and molecular neurobiology

Di Pietro C,Marazziti D,La Sala G,Abbaszadeh Z,Golini E,Matteoni R,Tocchini-Valentini GP

Sun Jan 01 00:00:00 EST 2017

Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro.

Cell and tissue research

Dores C,Alpaugh W,Su L,Biernaskie J,Dobrinski I

Sat Apr 01 00:00:00 EDT 2017

Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro.

Cell and tissue research

Dores C,Alpaugh W,Su L,Biernaskie J,Dobrinski I

Sat Apr 01 00:00:00 EDT 2017

Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.

Molecular biology of the cell

Flanagan AM,Stavenschi E,Basavaraju S,Gaboriau D,Hoey DA,Morrison CG

Wed Mar 15 00:00:00 EDT 2017

Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.

Molecular biology of the cell

Flanagan AM,Stavenschi E,Basavaraju S,Gaboriau D,Hoey DA,Morrison CG

Wed Mar 15 00:00:00 EDT 2017

Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.

Molecular biology of the cell

Katoh Y,Michisaka S,Nozaki S,Funabashi T,Hirano T,Takei R,Nakayama K

Sat Apr 01 00:00:00 EDT 2017

Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.

Molecular biology of the cell

Katoh Y,Michisaka S,Nozaki S,Funabashi T,Hirano T,Takei R,Nakayama K

Sat Apr 01 00:00:00 EDT 2017

Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.

Molecular biology of the cell

Funabashi T,Katoh Y,Michisaka S,Terada M,Sugawa M,Nakayama K

Wed Mar 01 00:00:00 EST 2017

Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.

Molecular biology of the cell

Funabashi T,Katoh Y,Michisaka S,Terada M,Sugawa M,Nakayama K

Wed Mar 01 00:00:00 EST 2017

Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division.

Developmental biology

Schock EN,Brugmann SA

Wed Nov 15 00:00:00 EST 2017

Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division.

Developmental biology

Schock EN,Brugmann SA

Wed Nov 15 00:00:00 EST 2017

Cilia-dependent GLI processing in neural crest cells is required for tongue development.

Developmental biology

Millington G,Elliott KH,Chang YT,Chang CF,Dlugosz A,Brugmann SA

Sat Apr 15 00:00:00 EDT 2017

Cilia-dependent GLI processing in neural crest cells is required for tongue development.

Developmental biology

Millington G,Elliott KH,Chang YT,Chang CF,Dlugosz A,Brugmann SA

Sat Apr 15 00:00:00 EDT 2017

SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.

Developmental biology

Zhao L,Arsenault M,Ng ET,Longmuss E,Chau TC,Hartwig S,Koopman P

Wed Mar 01 00:00:00 EST 2017

SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.

Developmental biology

Zhao L,Arsenault M,Ng ET,Longmuss E,Chau TC,Hartwig S,Koopman P

Wed Mar 01 00:00:00 EST 2017

A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.

Genesis (New York, N.Y. : 2000)

Schmitz F,Burtscher I,Stauber M,Gossler A,Lickert H

Wed Nov 01 00:00:00 EDT 2017

A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.

Genesis (New York, N.Y. : 2000)

Schmitz F,Burtscher I,Stauber M,Gossler A,Lickert H

Wed Nov 01 00:00:00 EDT 2017

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders.

Journal of visualized experiments : JoVE

Gabriel E,Gopalakrishnan J

Fri Apr 14 00:00:00 EDT 2017

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders.

Journal of visualized experiments : JoVE

Gabriel E,Gopalakrishnan J

Fri Apr 14 00:00:00 EDT 2017

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.

Cell reports

Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A

Tue Jul 11 00:00:00 EDT 2017

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.

Cell reports

Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A

Tue Jul 11 00:00:00 EDT 2017

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.

Cell reports

Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A

Tue Jul 11 00:00:00 EDT 2017

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.

Cell reports

Shimada H,Lu Q,Insinna-Kettenhofen C,Nagashima K,English MA,Semler EM,Mahgerefteh J,Cideciyan AV,Li T,Brooks BP,Gunay-Aygun M,Jacobson SG,Cogliati T,Westlake CJ,Swaroop A

Tue Jul 11 00:00:00 EDT 2017

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.

Journal of neuroinflammation

Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW

Tue Sep 19 00:00:00 EDT 2017

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.

Journal of neuroinflammation

Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW

Tue Sep 19 00:00:00 EDT 2017

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.

Journal of neuroinflammation

Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW

Tue Sep 19 00:00:00 EDT 2017

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.

Journal of neuroinflammation

Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW

Tue Sep 19 00:00:00 EDT 2017

Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.

Journal of neuroinflammation

Baek H,Shin HJ,Kim JJ,Shin N,Kim S,Yi MH,Zhang E,Hong J,Kang JW,Kim Y,Kim CS,Kim DW

Tue Sep 19 00:00:00 EDT 2017

Abnormal glycosylation in Joubert syndrome type 10.

Cilia

Kane MS,Davids M,Bond MR,Adams CJ,Grout ME,Phelps IG,O'Day DR,Dempsey JC,Li X,Golas G,Vezina G,Gunay-Aygun M,Hanover JA,Doherty D,He M,Malicdan MCV,Gahl WA,Boerkoel CF

Tue Aug 01 00:00:00 EDT 2023

Abnormal glycosylation in Joubert syndrome type 10.

Cilia

Kane MS,Davids M,Bond MR,Adams CJ,Grout ME,Phelps IG,O'Day DR,Dempsey JC,Li X,Golas G,Vezina G,Gunay-Aygun M,Hanover JA,Doherty D,He M,Malicdan MCV,Gahl WA,Boerkoel CF

Tue Aug 01 00:00:00 EDT 2023

The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W

Fri Dec 29 00:00:00 EST 2017

The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W

Fri Dec 29 00:00:00 EST 2017

The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W

Fri Dec 29 00:00:00 EST 2017

The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Sharif A,Yazigi H,Frederick JM,Baehr W

Fri Dec 29 00:00:00 EST 2017

Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.

The Journal of biological chemistry

Roy K,Jerman S,Jozsef L,McNamara T,Onyekaba G,Sun Z,Marin EP

Fri Oct 27 00:00:00 EDT 2017

Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.

The Journal of biological chemistry

Roy K,Jerman S,Jozsef L,McNamara T,Onyekaba G,Sun Z,Marin EP

Fri Oct 27 00:00:00 EDT 2017

Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.

The Journal of biological chemistry

Roy K,Jerman S,Jozsef L,McNamara T,Onyekaba G,Sun Z,Marin EP

Fri Oct 27 00:00:00 EDT 2017

Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.

The Journal of biological chemistry

Roy K,Jerman S,Jozsef L,McNamara T,Onyekaba G,Sun Z,Marin EP

Fri Oct 27 00:00:00 EDT 2017

Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.

Neural development

Rakotomamonjy J,Brunner M,Jüschke C,Zang K,Huang EJ,Reichardt LF,Chenn A

Mon May 08 00:00:00 EDT 2017

Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.

Neural development

Rakotomamonjy J,Brunner M,Jüschke C,Zang K,Huang EJ,Reichardt LF,Chenn A

Mon May 08 00:00:00 EDT 2017

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.

European cells & materials

Thompson CL,Plant JC,Wann AK,Bishop CL,Novak P,Mitchison HM,Beales PL,Chapple JP,Knight MM

Wed Sep 20 00:00:00 EDT 2017

Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.

Cilia

Duran I,Taylor SP,Zhang W,Martin J,Qureshi F,Jacques SM,Wallerstein R,Lachman RS,Nickerson DA,Bamshad M,Cohn DH,Krakow D

Wed Sep 30 00:00:00 EDT 2020

Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.

Cilia

Duran I,Taylor SP,Zhang W,Martin J,Qureshi F,Jacques SM,Wallerstein R,Lachman RS,Nickerson DA,Bamshad M,Cohn DH,Krakow D

Wed Sep 30 00:00:00 EDT 2020

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.

Scientific reports

Bizzotto S,Uzquiano A,Dingli F,Ershov D,Houllier A,Arras G,Richards M,Loew D,Minc N,Croquelois A,Houdusse A,Francis F

Mon Dec 11 00:00:00 EST 2017

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.

Scientific reports

Bizzotto S,Uzquiano A,Dingli F,Ershov D,Houllier A,Arras G,Richards M,Loew D,Minc N,Croquelois A,Houdusse A,Francis F

Mon Dec 11 00:00:00 EST 2017

Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.

PloS one

Nagai T,Mizuno K

Wed Oct 04 00:00:00 EDT 2017

Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.

PloS one

Nagai T,Mizuno K

Wed Oct 04 00:00:00 EDT 2017

An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations.

Scientific reports

Stayner C,Poole CA,McGlashan SR,Pilanthananond M,Brauning R,Markie D,Lett B,Slobbe L,Chae A,Johnstone AC,Jensen CG,McEwan JC,Dittmer K,Parker K,Wiles A,Blackburne W,Leichter A,Leask M,Pinnapureddy A,Jennings M,Horsfield JA,Walker RJ,Eccles MR

Tue May 09 00:00:00 EDT 2017

An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations.

Scientific reports

Tue May 09 00:00:00 EDT 2017

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.

Nature communications

Taulet N,Vitre B,Anguille C,Douanier A,Rocancourt M,Taschner M,Lorentzen E,Echard A,Delaval B

Mon Dec 04 00:00:00 EST 2017

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.

Nature communications

Taulet N,Vitre B,Anguille C,Douanier A,Rocancourt M,Taschner M,Lorentzen E,Echard A,Delaval B

Mon Dec 04 00:00:00 EST 2017

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

Nature communications

Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

Mon Jan 30 00:00:00 EST 2017

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.

Nature communications

Schou KB,Mogensen JB,Morthorst SK,Nielsen BS,Aleliunaite A,Serra-Marques A,Fürstenberg N,Saunier S,Bizet AA,Veland IR,Akhmanova A,Christensen ST,Pedersen LB

Mon Jan 30 00:00:00 EST 2017

Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.

Cell stem cell

Gabriel E,Ramani A,Karow U,Gottardo M,Natarajan K,Gooi LM,Goranci-Buzhala G,Krut O,Peters F,Nikolic M,Kuivanen S,Korhonen E,Smura T,Vapalahti O,Papantonis A,Schmidt-Chanasit J,Riparbelli M,Callaini G,Krönke M,Utermöhlen O,Gopalakrishnan J

Thu Mar 02 00:00:00 EST 2017

Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.

Cell stem cell

Thu Mar 02 00:00:00 EST 2017

Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.

Genes, brain, and behavior

Wang B,Zheng Y,Shi H,Du X,Zhang Y,Wei B,Luo M,Wang H,Wu X,Hua X,Sun M,Xu X

Wed Feb 01 00:00:00 EST 2017

Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.

Genes, brain, and behavior

Wang B,Zheng Y,Shi H,Du X,Zhang Y,Wei B,Luo M,Wang H,Wu X,Hua X,Sun M,Xu X

Wed Feb 01 00:00:00 EST 2017

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.

PloS one

Grzelak CA,Sigglekow ND,Tirnitz-Parker JE,Hamson EJ,Warren A,Maneck B,Chen J,Patkunanathan B,Boland J,Cheng R,Shackel NA,Seth D,Bowen DG,Martelotto LG,Watkins DN,McCaughan GW

Wed Aug 09 00:00:00 EDT 2017

Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.

PloS one

Grzelak CA,Sigglekow ND,Tirnitz-Parker JE,Hamson EJ,Warren A,Maneck B,Chen J,Patkunanathan B,Boland J,Cheng R,Shackel NA,Seth D,Bowen DG,Martelotto LG,Watkins DN,McCaughan GW

Wed Aug 09 00:00:00 EDT 2017

Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.

Human molecular genetics

Schwarz N,Lane A,Jovanovic K,Parfitt DA,Aguila M,Thompson CL,da Cruz L,Coffey PJ,Chapple JP,Hardcastle AJ,Cheetham ME

Sat Jul 01 00:00:00 EDT 2017

NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.

Cell research

Zhang C,Zhang W,Lu Y,Yan X,Yan X,Zhu X,Liu W,Yang Y,Zhou T

Mon Feb 01 00:00:00 EST 2016

Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.

Nature neuroscience

Wang L,Hou S,Han YG

Fri Jul 01 00:00:00 EDT 2016

Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.

Nature neuroscience

Wang L,Hou S,Han YG

Fri Jul 01 00:00:00 EDT 2016

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.

Nature cell biology

Lambacher NJ,Bruel AL,van Dam TJ,Szymańska K,Slaats GG,Kuhns S,McManus GJ,Kennedy JE,Gaff K,Wu KM,van der Lee R,Burglen L,Doummar D,Rivière JB,Faivre L,Attié-Bitach T,Saunier S,Curd A,Peckham M,Giles RH,Johnson CA,Huynen MA,Thauvin-Robinet C,Blacque OE

Fri Jan 01 00:00:00 EST 2016

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.

Nature cell biology

Fri Jan 01 00:00:00 EST 2016

Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.

Nature cell biology

Li L,Grausam KB,Wang J,Lun MP,Ohli J,Lidov HG,Calicchio ML,Zeng E,Salisbury JL,Wechsler-Reya RJ,Lehtinen MK,Schüller U,Zhao H

Fri Apr 01 00:00:00 EDT 2016

Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.

Nature cell biology

Li L,Grausam KB,Wang J,Lun MP,Ohli J,Lidov HG,Calicchio ML,Zeng E,Salisbury JL,Wechsler-Reya RJ,Lehtinen MK,Schüller U,Zhao H

Fri Apr 01 00:00:00 EDT 2016

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.

Cell stem cell

Parfitt DA,Lane A,Ramsden CM,Carr AF,Munro PM,Jovanovic K,Schwarz N,Kanuga N,Muthiah MN,Hull S,Gallo JM,da Cruz L,Moore AT,Hardcastle AJ,Coffey PJ,Cheetham ME

Thu Jun 02 00:00:00 EDT 2016

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.

Cell stem cell

Parfitt DA,Lane A,Ramsden CM,Carr AF,Munro PM,Jovanovic K,Schwarz N,Kanuga N,Muthiah MN,Hull S,Gallo JM,da Cruz L,Moore AT,Hardcastle AJ,Coffey PJ,Cheetham ME

Thu Jun 02 00:00:00 EDT 2016

Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.

Journal of the American Society of Nephrology : JASN

Li Y,Tian X,Ma M,Jerman S,Kong S,Somlo S,Sun Z

Thu Dec 01 00:00:00 EST 2016

Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.

Journal of the American Society of Nephrology : JASN

Li Y,Tian X,Ma M,Jerman S,Kong S,Somlo S,Sun Z

Thu Dec 01 00:00:00 EST 2016

CPAP promotes timely cilium disassembly to maintain neural progenitor pool.

The EMBO journal

Gabriel E,Wason A,Ramani A,Gooi LM,Keller P,Pozniakovsky A,Poser I,Noack F,Telugu NS,Calegari F,Šarić T,Hescheler J,Hyman AA,Gottardo M,Callaini G,Alkuraya FS,Gopalakrishnan J

Fri Apr 15 00:00:00 EDT 2016

CPAP promotes timely cilium disassembly to maintain neural progenitor pool.

The EMBO journal

Gabriel E,Wason A,Ramani A,Gooi LM,Keller P,Pozniakovsky A,Poser I,Noack F,Telugu NS,Calegari F,Šarić T,Hescheler J,Hyman AA,Gottardo M,Callaini G,Alkuraya FS,Gopalakrishnan J

Fri Apr 15 00:00:00 EDT 2016

Endothelial primary cilia inhibit atherosclerosis.

EMBO reports

Dinsmore C,Reiter JF

Mon Feb 01 00:00:00 EST 2016

Endothelial primary cilia inhibit atherosclerosis.

EMBO reports

Dinsmore C,Reiter JF

Mon Feb 01 00:00:00 EST 2016

Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium.

EMBO reports

Sánchez A,Urrego D,Pardo LA

Sun May 01 00:00:00 EDT 2016

Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium.

EMBO reports

Sánchez A,Urrego D,Pardo LA

Sun May 01 00:00:00 EDT 2016

Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.

Development (Cambridge, England)

Yadav SP,Sharma NK,Liu C,Dong L,Li T,Swaroop A

Sun May 01 00:00:00 EDT 2016

Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.

Development (Cambridge, England)

Yadav SP,Sharma NK,Liu C,Dong L,Li T,Swaroop A

Sun May 01 00:00:00 EDT 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Slaats GG,Isabella CR,Kroes HY,Dempsey JC,Gremmels H,Monroe GR,Phelps IG,Duran KJ,Adkins J,Kumar SA,Knutzen DM,Knoers NV,Mendelsohn NJ,Neubauer D,Mastroyianni SD,Vogt J,Worgan L,Karp N,Bowdin S,Glass IA,Parisi MA,Otto EA,Johnson CA,Hildebrandt F,van Haaften G,Giles RH,Doherty D

Fri Jan 01 00:00:00 EST 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Fri Jan 01 00:00:00 EST 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Fri Jan 01 00:00:00 EST 2016

MKS1 regulates ciliary INPP5E levels in Joubert syndrome.

Journal of medical genetics

Fri Jan 01 00:00:00 EST 2016

Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Thompson CL,Wiles A,Poole CA,Knight MM

Mon Feb 01 00:00:00 EST 2016

Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Thompson CL,Wiles A,Poole CA,Knight MM

Mon Feb 01 00:00:00 EST 2016

Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.

Experimental neurology

Parker AK,Le MM,Smith TS,Hoang-Minh LB,Atkinson EW,Ugartemendia G,Semple-Rowland S,Coleman JE,Sarkisian MR

Mon Aug 01 00:00:00 EDT 2016

Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.

Experimental neurology

Parker AK,Le MM,Smith TS,Hoang-Minh LB,Atkinson EW,Ugartemendia G,Semple-Rowland S,Coleman JE,Sarkisian MR

Mon Aug 01 00:00:00 EDT 2016

Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.

Journal of immunology (Baltimore, Md. : 1950)

Giridhar PV,Bell SM,Sridharan A,Rajavelu P,Kitzmiller JA,Na CL,Kofron M,Brandt EB,Ericksen M,Naren AP,Moon C,Khurana Hershey GK,Whitsett JA

Thu Dec 01 00:00:00 EST 2016

Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.

Journal of immunology (Baltimore, Md. : 1950)

Giridhar PV,Bell SM,Sridharan A,Rajavelu P,Kitzmiller JA,Na CL,Kofron M,Brandt EB,Ericksen M,Naren AP,Moon C,Khurana Hershey GK,Whitsett JA

Thu Dec 01 00:00:00 EST 2016

WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.

Journal of cell science

Kurtulmus B,Wang W,Ruppert T,Neuner A,Cerikan B,Viol L,Dueñas-Sánchez R,Gruss OJ,Pereira G

Mon Feb 01 00:00:00 EST 2016

WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.

Journal of cell science

Kurtulmus B,Wang W,Ruppert T,Neuner A,Cerikan B,Viol L,Dueñas-Sánchez R,Gruss OJ,Pereira G

Mon Feb 01 00:00:00 EST 2016

IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.

Human molecular genetics

Zhang W,Taylor SP,Nevarez L,Lachman RS,Nickerson DA,Bamshad M,Krakow D,Cohn DH

Thu Sep 15 00:00:00 EDT 2016

IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.

Human molecular genetics

Zhang W,Taylor SP,Nevarez L,Lachman RS,Nickerson DA,Bamshad M,Krakow D,Cohn DH

Thu Sep 15 00:00:00 EDT 2016

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

Human molecular genetics

Paige Taylor S,Kunova Bosakova M,Varecha M,Balek L,Barta T,Trantirek L,Jelinkova I,Duran I,Vesela I,Forlenza KN,Martin JH,Hampl A,Bamshad M,Nickerson D,Jaworski ML,Song J,Ko HW,Cohn DH,Krakow D,Krejci P

Thu Sep 15 00:00:00 EDT 2016

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

Human molecular genetics

Thu Sep 15 00:00:00 EDT 2016

Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.

Human molecular genetics

Casey JP,Brennan K,Scheidel N,McGettigan P,Lavin PT,Carter S,Ennis S,Dorkins H,Ghali N,Blacque OE,Mc Gee MM,Murphy H,Lynch SA

Sun May 01 00:00:00 EDT 2016

Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.

Human molecular genetics

Casey JP,Brennan K,Scheidel N,McGettigan P,Lavin PT,Carter S,Ennis S,Dorkins H,Ghali N,Blacque OE,Mc Gee MM,Murphy H,Lynch SA

Sun May 01 00:00:00 EDT 2016

Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish.

Investigative ophthalmology & visual science

Song P,Dudinsky L,Fogerty J,Gaivin R,Perkins BD

Mon Aug 01 00:00:00 EDT 2016

Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish.

Investigative ophthalmology & visual science

Song P,Dudinsky L,Fogerty J,Gaivin R,Perkins BD

Mon Aug 01 00:00:00 EDT 2016

Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4^lps-2J/J mouse cortex.

Neuroscience

Ramos RL,Toia AR,Pasternack DM,Dotzler TP,Cuoco JA,Esposito AW,Le MM,Parker AK,Goodman JH,Sarkisian MR

Sat Nov 19 00:00:00 EST 2016

Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4^lps-2J/J mouse cortex.

Neuroscience

Ramos RL,Toia AR,Pasternack DM,Dotzler TP,Cuoco JA,Esposito AW,Le MM,Parker AK,Goodman JH,Sarkisian MR

Sat Nov 19 00:00:00 EST 2016

Arl13b and the exocyst interact synergistically in ciliogenesis.

Molecular biology of the cell

Seixas C,Choi SY,Polgar N,Umberger NL,East MP,Zuo X,Moreiras H,Ghossoub R,Benmerah A,Kahn RA,Fogelgren B,Caspary T,Lipschutz JH,Barral DC

Fri Jan 15 00:00:00 EST 2016

Arl13b and the exocyst interact synergistically in ciliogenesis.

Molecular biology of the cell

Seixas C,Choi SY,Polgar N,Umberger NL,East MP,Zuo X,Moreiras H,Ghossoub R,Benmerah A,Kahn RA,Fogelgren B,Caspary T,Lipschutz JH,Barral DC

Fri Jan 15 00:00:00 EST 2016

Arl13b and the exocyst interact synergistically in ciliogenesis.

Molecular biology of the cell

Seixas C,Choi SY,Polgar N,Umberger NL,East MP,Zuo X,Moreiras H,Ghossoub R,Benmerah A,Kahn RA,Fogelgren B,Caspary T,Lipschutz JH,Barral DC

Fri Jan 15 00:00:00 EST 2016

Arl13b and the exocyst interact synergistically in ciliogenesis.

Molecular biology of the cell

Seixas C,Choi SY,Polgar N,Umberger NL,East MP,Zuo X,Moreiras H,Ghossoub R,Benmerah A,Kahn RA,Fogelgren B,Caspary T,Lipschutz JH,Barral DC

Fri Jan 15 00:00:00 EST 2016

RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.

Biology open

Dutta N,Seo S

Thu Sep 15 00:00:00 EDT 2016

RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.

Biology open

Dutta N,Seo S

Thu Sep 15 00:00:00 EDT 2016

Immunofluorescent staining of septins in primary cilia.

Methods in cell biology

Kim MS,Froese CD,Xie H,Trimble WS

Mon Aug 21 00:00:00 EDT 2017

Immunofluorescent staining of septins in primary cilia.

Methods in cell biology

Kim MS,Froese CD,Xie H,Trimble WS

Mon Aug 21 00:00:00 EDT 2017

Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation.

Molecular vision

Chen HY,Kaya KD,Dong L,Swaroop A

Fri Mar 06 00:00:00 EST 2020

Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation.

Molecular vision

Chen HY,Kaya KD,Dong L,Swaroop A

Fri Mar 06 00:00:00 EST 2020

Targeting of ASH Domain-Containing Proteins to the Centrosome.

Methods in molecular biology (Clifton, N.J.)

Verdier P,Morthorst SK,Pedersen LB

Fri Jan 12 00:00:00 EST 2018

Nestin Mediates Hedgehog Pathway Tumorigenesis.

Cancer research

Li P,Lee EH,Du F,Gordon RE,Yuelling LW,Liu Y,Ng JM,Zhang H,Wu J,Korshunov A,Pfister SM,Curran T,Yang ZJ

Thu Sep 15 00:00:00 EDT 2016

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.

Oncotarget

Lee J,Yi S,Kang YE,Chang JY,Kim JT,Sul HJ,Kim JO,Kim JM,Kim J,Porcelli AM,Kim KS,Shong M

Tue Nov 29 00:00:00 EST 2016

Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.

Oncotarget

Lee J,Yi S,Kang YE,Chang JY,Kim JT,Sul HJ,Kim JO,Kim JM,Kim J,Porcelli AM,Kim KS,Shong M

Tue Nov 29 00:00:00 EST 2016

Prenylated retinal ciliopathy protein RPGR interacts with PDE6δ and regulates ciliary localization of Joubert syndrome-associated protein INPP5E.

Human molecular genetics

Rao KN,Zhang W,Li L,Anand M,Khanna H

Sat Oct 15 00:00:00 EDT 2016

Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model.

PloS one

Choi H,Shin JH,Kim ES,Park SJ,Bae IH,Jo YK,Jeong IY,Kim HJ,Lee Y,Park HC,Jeon HB,Kim KW,Lee TR,Cho DH

Wed Jun 28 00:00:00 EDT 2017

Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model.

PloS one

Choi H,Shin JH,Kim ES,Park SJ,Bae IH,Jo YK,Jeong IY,Kim HJ,Lee Y,Park HC,Jeon HB,Kim KW,Lee TR,Cho DH

Wed Jun 28 00:00:00 EDT 2017

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

Nature communications

Boldt K,van Reeuwijk J,Lu Q,Koutroumpas K,Nguyen TM,Texier Y,van Beersum SE,Horn N,Willer JR,Mans DA,Dougherty G,Lamers IJ,Coene KL,Arts HH,Betts MJ,Beyer T,Bolat E,Gloeckner CJ,Haidari K,Hetterschijt L,Iaconis D,Jenkins D,Klose F,Knapp B,Latour B,Letteboer SJ,Marcelis CL,Mitic D,Morleo M,Oud MM,Riemersma M,Rix S,Terhal PA,Toedt G,van Dam TJ,de Vrieze E,Wissinger Y,Wu KM,Apic G,Beales PL,Blacque OE,Gibson TJ,Huynen MA,Katsanis N,Kremer H,Omran H,van Wijk E,Wolfrum U,Kepes F,Davis EE,Franco B,Giles RH,Ueffing M,Russell RB,Roepman R

Fri May 13 00:00:00 EDT 2016

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

Nature communications

Fri May 13 00:00:00 EDT 2016

Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.

Nature communications

Doobin DJ,Kemal S,Dantas TJ,Vallee RB

Wed Aug 24 00:00:00 EDT 2016

Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.

Nature communications

Doobin DJ,Kemal S,Dantas TJ,Vallee RB

Wed Aug 24 00:00:00 EDT 2016

A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.

Cilia

Oud MM,Bonnard C,Mans DA,Altunoglu U,Tohari S,Ng AYJ,Eskin A,Lee H,Rupar CA,de Wagenaar NP,Wu KM,Lahiry P,Pazour GJ,Nelson SF,Hegele RA,Roepman R,Kayserili H,Venkatesh B,Siu VM,Reversade B,Arts HH

Tue Apr 12 00:00:00 EDT 2016

A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.

Cilia

Oud MM,Bonnard C,Mans DA,Altunoglu U,Tohari S,Ng AYJ,Eskin A,Lee H,Rupar CA,de Wagenaar NP,Wu KM,Lahiry P,Pazour GJ,Nelson SF,Hegele RA,Roepman R,Kayserili H,Venkatesh B,Siu VM,Reversade B,Arts HH

Tue Apr 12 00:00:00 EDT 2016

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports

Fu W,Wang L,Kim S,Li J,Dynlacht BD

Tue Nov 01 00:00:00 EDT 2016

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports

Fu W,Wang L,Kim S,Li J,Dynlacht BD

Tue Nov 01 00:00:00 EDT 2016

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports

Fu W,Wang L,Kim S,Li J,Dynlacht BD

Tue Nov 01 00:00:00 EDT 2016

Role for the IFT-A Complex in Selective Transport to the Primary Cilium.

Cell reports

Fu W,Wang L,Kim S,Li J,Dynlacht BD

Tue Nov 01 00:00:00 EDT 2016

Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)

Ghossoub R,Lindbæk L,Molla-Herman A,Schmitt A,Christensen ST,Benmerah A

Fri Jan 12 00:00:00 EST 2018

Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)

Ghossoub R,Lindbæk L,Molla-Herman A,Schmitt A,Christensen ST,Benmerah A

Fri Jan 12 00:00:00 EST 2018

KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.

Scientific reports

Kim M,Suh YA,Oh JH,Lee BR,Kim J,Jang SJ

Tue Sep 06 00:00:00 EDT 2016

KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.

Scientific reports

Kim M,Suh YA,Oh JH,Lee BR,Kim J,Jang SJ

Tue Sep 06 00:00:00 EDT 2016

MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.

Scientific reports

Lee SH,Lee MS,Choi TI,Hong H,Seo JY,Kim CH,Kim J

Mon Jun 06 00:00:00 EDT 2016

MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.

Scientific reports

Lee SH,Lee MS,Choi TI,Hong H,Seo JY,Kim CH,Kim J

Mon Jun 06 00:00:00 EDT 2016

Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.

PLoS genetics

Chang CF,Chang YT,Millington G,Brugmann SA

Tue Nov 01 00:00:00 EDT 2016

Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.

PLoS genetics

Chang CF,Chang YT,Millington G,Brugmann SA

Tue Nov 01 00:00:00 EDT 2016

Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.

PLoS genetics

Hong CJ,Hamilton BA

Sat Oct 01 00:00:00 EDT 2016

Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.

PLoS genetics

Hong CJ,Hamilton BA

Sat Oct 01 00:00:00 EDT 2016

Methods for Visualization of Neuronal Cilia.

Methods in molecular biology (Clifton, N.J.)

Caspary T,Marazziti D,Berbari NF

Fri Jan 12 00:00:00 EST 2018

Methods for Visualization of Neuronal Cilia.

Methods in molecular biology (Clifton, N.J.)

Caspary T,Marazziti D,Berbari NF

Fri Jan 12 00:00:00 EST 2018

Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.

Scientific reports

Duran I,Taylor SP,Zhang W,Martin J,Forlenza KN,Spiro RP,Nickerson DA,Bamshad M,Cohn DH,Krakow D

Mon Sep 26 00:00:00 EDT 2016

Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.

Scientific reports

Duran I,Taylor SP,Zhang W,Martin J,Forlenza KN,Spiro RP,Nickerson DA,Bamshad M,Cohn DH,Krakow D

Mon Sep 26 00:00:00 EDT 2016

Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.

Oncotarget

Hoang-Minh LB,Deleyrolle LP,Siebzehnrubl D,Ugartemendia G,Futch H,Griffith B,Breunig JJ,De Leon G,Mitchell DA,Semple-Rowland S,Reynolds BA,Sarkisian MR

Tue Feb 09 00:00:00 EST 2016

Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.

Oncotarget

Hoang-Minh LB,Deleyrolle LP,Siebzehnrubl D,Ugartemendia G,Futch H,Griffith B,Breunig JJ,De Leon G,Mitchell DA,Semple-Rowland S,Reynolds BA,Sarkisian MR

Tue Feb 09 00:00:00 EST 2016

Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Gerstner CD,Frederick JM,Zhang H,Baehr W

Fri Mar 25 00:00:00 EDT 2016

Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Gerstner CD,Frederick JM,Zhang H,Baehr W

Fri Mar 25 00:00:00 EDT 2016

Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Gerstner CD,Frederick JM,Zhang H,Baehr W

Fri Mar 25 00:00:00 EDT 2016

Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.

The Journal of biological chemistry

Hanke-Gogokhia C,Wu Z,Gerstner CD,Frederick JM,Zhang H,Baehr W

Fri Mar 25 00:00:00 EDT 2016

Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.

Cell reports

May-Simera HL,Gumerson JD,Gao C,Campos M,Cologna SM,Beyer T,Boldt K,Kaya KD,Patel N,Kretschmer F,Kelley MW,Petralia RS,Davey MG,Li T

Tue Oct 25 00:00:00 EDT 2016

Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.

Cell reports

May-Simera HL,Gumerson JD,Gao C,Campos M,Cologna SM,Beyer T,Boldt K,Kaya KD,Patel N,Kretschmer F,Kelley MW,Petralia RS,Davey MG,Li T

Tue Oct 25 00:00:00 EDT 2016

Measuring the primary cilium length: improved method for unbiased high-throughput analysis.

Cilia

Dummer A,Poelma C,DeRuiter MC,Goumans MJ,Hierck BP

Fri Feb 12 00:00:00 EST 2016

Measuring the primary cilium length: improved method for unbiased high-throughput analysis.

Cilia

Dummer A,Poelma C,DeRuiter MC,Goumans MJ,Hierck BP

Fri Feb 12 00:00:00 EST 2016

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Nature cell biology

Wheway G,Schmidts M,Mans DA,Szymanska K,Nguyen TT,Racher H,Phelps IG,Toedt G,Kennedy J,Wunderlich KA,Sorusch N,Abdelhamed ZA,Natarajan S,Herridge W,van Reeuwijk J,Horn N,Boldt K,Parry DA,Letteboer SJF,Roosing S,Adams M,Bell SM,Bond J,Higgins J,Morrison EE,Tomlinson DC,Slaats GG,van Dam TJP,Huang L,Kessler K,Giessl A,Logan CV,Boyle EA,Shendure J,Anazi S,Aldahmesh M,Al Hazzaa S,Hegele RA,Ober C,Frosk P,Mhanni AA,Chodirker BN,Chudley AE,Lamont R,Bernier FP,Beaulieu CL,Gordon P,Pon RT,Donahue C,Barkovich AJ,Wolf L,Toomes C,Thiel CT,Boycott KM,McKibbin M,Inglehearn CF,Stewart F,Omran H,Huynen MA,Sergouniotis PI,Alkuraya FS,Parboosingh JS,Innes AM,Willoughby CE,Giles RH,Webster AR,Ueffing M,Blacque O,Gleeson JG,Wolfrum U,Beales PL,Gibson T,Doherty D,Mitchison HM,Roepman R,Johnson CA

Sat Aug 01 00:00:00 EDT 2015

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Nature cell biology

Sat Aug 01 00:00:00 EDT 2015

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

The Journal of clinical investigation

Gainullin VG,Hopp K,Ward CJ,Hommerding CJ,Harris PC

Sun Feb 01 00:00:00 EST 2015

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.

The Journal of clinical investigation

Gainullin VG,Hopp K,Ward CJ,Hommerding CJ,Harris PC

Sun Feb 01 00:00:00 EST 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 EDT 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 EDT 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 EDT 2015

Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Datta P,Allamargot C,Hudson JS,Andersen EK,Bhattarai S,Drack AV,Sheffield VC,Seo S

Tue Aug 11 00:00:00 EDT 2015

Centrin2 regulates CP110 removal in primary cilium formation.

The Journal of cell biology

Prosser SL,Morrison CG

Mon Mar 16 00:00:00 EDT 2015

Centrin2 regulates CP110 removal in primary cilium formation.

The Journal of cell biology

Prosser SL,Morrison CG

Mon Mar 16 00:00:00 EDT 2015

Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression.

The Journal of investigative dermatology

Snedecor ER,Sung CC,Moncayo A,Rothstein BE,Mockler DC,Tonnesen MG,Jones EC,Fujita M,Clark RA,Shroyer KR,Chen J

Fri May 01 00:00:00 EDT 2015

Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression.

The Journal of investigative dermatology

Snedecor ER,Sung CC,Moncayo A,Rothstein BE,Mockler DC,Tonnesen MG,Jones EC,Fujita M,Clark RA,Shroyer KR,Chen J

Fri May 01 00:00:00 EDT 2015

Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Joiner AM,Green WW,McIntyre JC,Allen BL,Schwob JE,Martens JR

Wed Oct 07 00:00:00 EDT 2015

Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Joiner AM,Green WW,McIntyre JC,Allen BL,Schwob JE,Martens JR

Wed Oct 07 00:00:00 EDT 2015

Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.

Journal of medical genetics

Malicdan MC,Vilboux T,Stephen J,Maglic D,Mian L,Konzman D,Guo J,Yildirimli D,Bryant J,Fischer R,Zein WM,Snow J,Vemulapalli M,Mullikin JC,Toro C,Solomon BD,Niederhuber JE,Gahl WA,Gunay-Aygun M

Tue Dec 01 00:00:00 EST 2015

Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.

Journal of medical genetics

Malicdan MC,Vilboux T,Stephen J,Maglic D,Mian L,Konzman D,Guo J,Yildirimli D,Bryant J,Fischer R,Zein WM,Snow J,Vemulapalli M,Mullikin JC,Toro C,Solomon BD,Niederhuber JE,Gahl WA,Gunay-Aygun M

Tue Dec 01 00:00:00 EST 2015

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.

Structure (London, England : 1993)

Lokaj M,Kösling SK,Koerner C,Lange SM,van Beersum SE,van Reeuwijk J,Roepman R,Horn N,Ueffing M,Boldt K,Wittinghofer A

Tue Nov 03 00:00:00 EST 2015

The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.

Structure (London, England : 1993)

Lokaj M,Kösling SK,Koerner C,Lange SM,van Beersum SE,van Reeuwijk J,Roepman R,Horn N,Ueffing M,Boldt K,Wittinghofer A

Tue Nov 03 00:00:00 EST 2015

The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.

Journal of cell science

Carpenter BS,Barry RL,Verhey KJ,Allen BL

Sun Mar 01 00:00:00 EST 2015

The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.

Journal of cell science

Carpenter BS,Barry RL,Verhey KJ,Allen BL

Sun Mar 01 00:00:00 EST 2015

PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.

Journal of cell science

Nielsen BS,Malinda RR,Schmid FM,Pedersen SF,Christensen ST,Pedersen LB

Thu Oct 01 00:00:00 EDT 2015

PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.

Journal of cell science

Nielsen BS,Malinda RR,Schmid FM,Pedersen SF,Christensen ST,Pedersen LB

Thu Oct 01 00:00:00 EDT 2015

A role for Rab23 in the trafficking of Kif17 to the primary cilium.

Journal of cell science

Lim YS,Tang BL

Sat Aug 15 00:00:00 EDT 2015

A role for Rab23 in the trafficking of Kif17 to the primary cilium.

Journal of cell science

Lim YS,Tang BL

Sat Aug 15 00:00:00 EDT 2015

Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.

Journal of cellular biochemistry

Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

Tue Sep 01 00:00:00 EDT 2015

Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.

Journal of cellular biochemistry

Chen TY,Syu JS,Han TY,Cheng HL,Lu FI,Wang CY

Tue Sep 01 00:00:00 EDT 2015

Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.

Biochemical and biophysical research communications

Hong H,Kim J,Kim J

Fri May 22 00:00:00 EDT 2015

Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.

Biochemical and biophysical research communications

Hong H,Kim J,Kim J

Fri May 22 00:00:00 EDT 2015

A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.

Developmental biology

Lu H,Toh MT,Narasimhan V,Thamilselvam SK,Choksi SP,Roy S

Thu Jan 15 00:00:00 EST 2015

A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.

Developmental biology

Lu H,Toh MT,Narasimhan V,Thamilselvam SK,Choksi SP,Roy S

Thu Jan 15 00:00:00 EST 2015

Imaging centrosomes and cilia in the mouse kidney.

Methods in cell biology

Hoshi M,Wang J,Jain S,Mahjoub MR

Tue Jan 26 00:00:00 EST 2016

Imaging centrosomes and cilia in the mouse kidney.

Methods in cell biology

Hoshi M,Wang J,Jain S,Mahjoub MR

Tue Jan 26 00:00:00 EST 2016

Analysis of primary cilia in the developing mouse brain.

Methods in cell biology

Paridaen JT,Huttner WB,Wilsch-Bräuninger M

Tue Jan 26 00:00:00 EST 2016

Analysis of primary cilia in the developing mouse brain.

Methods in cell biology

Paridaen JT,Huttner WB,Wilsch-Bräuninger M

Tue Jan 26 00:00:00 EST 2016

Analysis of primary cilia in the developing mouse brain.

Methods in cell biology

Paridaen JT,Huttner WB,Wilsch-Bräuninger M

Tue Jan 26 00:00:00 EST 2016

Analysis of primary cilia in the developing mouse brain.

Methods in cell biology

Paridaen JT,Huttner WB,Wilsch-Bräuninger M

Tue Jan 26 00:00:00 EST 2016

Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.

Cells

Majumder S,Cash A,Fisk HA

Fri Jul 31 00:00:00 EDT 2015

Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.

Cells

Majumder S,Cash A,Fisk HA

Fri Jul 31 00:00:00 EDT 2015

Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.

Scientific reports

Rao KN,Li L,Anand M,Khanna H

Thu Jun 11 00:00:00 EDT 2015

Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.

Scientific reports

Rao KN,Li L,Anand M,Khanna H

Thu Jun 11 00:00:00 EDT 2015

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.

Nature communications

Taylor SP,Dantas TJ,Duran I,Wu S,Lachman RS,Nelson SF,Cohn DH,Vallee RB,Krakow D

Tue Jun 16 00:00:00 EDT 2015

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.

Nature communications

Taylor SP,Dantas TJ,Duran I,Wu S,Lachman RS,Nelson SF,Cohn DH,Vallee RB,Krakow D

Tue Jun 16 00:00:00 EDT 2015

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.

Cell reports

Miyamoto T,Hosoba K,Ochiai H,Royba E,Izumi H,Sakuma T,Yamamoto T,Dynlacht BD,Matsuura S

Tue Feb 10 00:00:00 EST 2015

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.

Cell reports

Miyamoto T,Hosoba K,Ochiai H,Royba E,Izumi H,Sakuma T,Yamamoto T,Dynlacht BD,Matsuura S

Tue Feb 10 00:00:00 EST 2015

The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.

The Journal of biological chemistry

Singh J,Wen X,Scales SJ

Fri Dec 04 00:00:00 EST 2015

The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.

The Journal of biological chemistry

Singh J,Wen X,Scales SJ

Fri Dec 04 00:00:00 EST 2015

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.

PloS one

Jiang S,Du J,Kong Q,Li C,Li Y,Sun H,Pu J,Mao B

Wed Jun 01 00:00:00 EDT 2016

A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.

PloS one

Jiang S,Du J,Kong Q,Li C,Li Y,Sun H,Pu J,Mao B

Wed Jun 01 00:00:00 EDT 2016

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.

Nature communications

Bizet AA,Becker-Heck A,Ryan R,Weber K,Filhol E,Krug P,Halbritter J,Delous M,Lasbennes MC,Linghu B,Oakeley EJ,Zarhrate M,Nitschké P,Garfa-Traore M,Serluca F,Yang F,Bouwmeester T,Pinson L,Cassuto E,Dubot P,Elshakhs NAS,Sahel JA,Salomon R,Drummond IA,Gubler MC,Antignac C,Chibout S,Szustakowski JD,Hildebrandt F,Lorentzen E,Sailer AW,Benmerah A,Saint-Mezard P,Saunier S

Wed Oct 21 00:00:00 EDT 2015

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.

Nature communications

Wed Oct 21 00:00:00 EDT 2015

Culture and detection of primary cilia in endothelial cell models.

Cilia

Lim YC,McGlashan SR,Cooling MT,Long DS

Fri Oct 02 00:00:00 EDT 2015

Culture and detection of primary cilia in endothelial cell models.

Cilia

Lim YC,McGlashan SR,Cooling MT,Long DS

Fri Oct 02 00:00:00 EDT 2015

Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.

Scientific reports

Nygaard MB,Almstrup K,Lindbæk L,Christensen ST,Svingen T

Wed May 20 00:00:00 EDT 2015

Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.

Scientific reports

Nygaard MB,Almstrup K,Lindbæk L,Christensen ST,Svingen T

Wed May 20 00:00:00 EDT 2015

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.

PLoS genetics

Yee LE,Garcia-Gonzalo FR,Bowie RV,Li C,Kennedy JK,Ashrafi K,Blacque OE,Leroux MR,Reiter JF

Sun Nov 01 00:00:00 EDT 2015

Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.

PLoS genetics

Yee LE,Garcia-Gonzalo FR,Bowie RV,Li C,Kennedy JK,Ashrafi K,Blacque OE,Leroux MR,Reiter JF

Sun Nov 01 00:00:00 EDT 2015

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Cell metabolism

Stratigopoulos G,Martin Carli JF,O'Day DR,Wang L,Leduc CA,Lanzano P,Chung WK,Rosenbaum M,Egli D,Doherty DA,Leibel RL

Tue May 06 00:00:00 EDT 2014

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Cell metabolism

Stratigopoulos G,Martin Carli JF,O'Day DR,Wang L,Leduc CA,Lanzano P,Chung WK,Rosenbaum M,Egli D,Doherty DA,Leibel RL

Tue May 06 00:00:00 EDT 2014

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Nature cell biology

Jin D,Ni TT,Sun J,Wan H,Amack JD,Yu G,Fleming J,Chiang C,Li W,Papierniak A,Cheepala S,Conseil G,Cole SP,Zhou B,Drummond IA,Schuetz JD,Malicki J,Zhong TP

Mon Sep 01 00:00:00 EDT 2014

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Nature cell biology

Jin D,Ni TT,Sun J,Wan H,Amack JD,Yu G,Fleming J,Chiang C,Li W,Papierniak A,Cheepala S,Conseil G,Cole SP,Zhou B,Drummond IA,Schuetz JD,Malicki J,Zhong TP

Mon Sep 01 00:00:00 EDT 2014

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Nature cell biology

Jin D,Ni TT,Sun J,Wan H,Amack JD,Yu G,Fleming J,Chiang C,Li W,Papierniak A,Cheepala S,Conseil G,Cole SP,Zhou B,Drummond IA,Schuetz JD,Malicki J,Zhong TP

Mon Sep 01 00:00:00 EDT 2014

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.

Nature cell biology

Jin D,Ni TT,Sun J,Wan H,Amack JD,Yu G,Fleming J,Chiang C,Li W,Papierniak A,Cheepala S,Conseil G,Cole SP,Zhou B,Drummond IA,Schuetz JD,Malicki J,Zhong TP

Mon Sep 01 00:00:00 EDT 2014

A homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS.

Journal of the American Society of Nephrology : JASN

Huynh Cong E,Bizet AA,Boyer O,Woerner S,Gribouval O,Filhol E,Arrondel C,Thomas S,Silbermann F,Canaud G,Hachicha J,Ben Dhia N,Peraldi MN,Harzallah K,Iftene D,Daniel L,Willems M,Noel LH,Bole-Feysot C,Nitschké P,Gubler MC,Mollet G,Saunier S,Antignac C

Sat Nov 01 00:00:00 EDT 2014

A homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS.

Journal of the American Society of Nephrology : JASN

Sat Nov 01 00:00:00 EDT 2014

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.

The EMBO journal

Chaya T,Omori Y,Kuwahara R,Furukawa T

Mon Jun 02 00:00:00 EDT 2014

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.

The EMBO journal

Chaya T,Omori Y,Kuwahara R,Furukawa T

Mon Jun 02 00:00:00 EDT 2014

Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.

Proceedings of the National Academy of Sciences of the United States of America

Čajánek L,Nigg EA

Tue Jul 15 00:00:00 EDT 2014

Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.

Proceedings of the National Academy of Sciences of the United States of America

Čajánek L,Nigg EA

Tue Jul 15 00:00:00 EDT 2014

Arhgap36-dependent activation of Gli transcription factors.

Proceedings of the National Academy of Sciences of the United States of America

Rack PG,Ni J,Payumo AY,Nguyen V,Crapster JA,Hovestadt V,Kool M,Jones DT,Mich JK,Firestone AJ,Pfister SM,Cho YJ,Chen JK

Tue Jul 29 00:00:00 EDT 2014

Arhgap36-dependent activation of Gli transcription factors.

Proceedings of the National Academy of Sciences of the United States of America

Rack PG,Ni J,Payumo AY,Nguyen V,Crapster JA,Hovestadt V,Kool M,Jones DT,Mich JK,Firestone AJ,Pfister SM,Cho YJ,Chen JK

Tue Jul 29 00:00:00 EDT 2014

Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.

American journal of human genetics

Roosing S,Lamers IJ,de Vrieze E,van den Born LI,Lambertus S,Arts HH,Peters TA,Hoyng CB,Kremer H,Hetterschijt L,Letteboer SJ,van Wijk E,Roepman R,den Hollander AI,Cremers FP

Thu Aug 07 00:00:00 EDT 2014

Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.

American journal of human genetics

Roosing S,Lamers IJ,de Vrieze E,van den Born LI,Lambertus S,Arts HH,Peters TA,Hoyng CB,Kremer H,Hetterschijt L,Letteboer SJ,van Wijk E,Roepman R,den Hollander AI,Cremers FP

Thu Aug 07 00:00:00 EDT 2014

Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.

The Journal of cell biology

Kong D,Farmer V,Shukla A,James J,Gruskin R,Kiriyama S,Loncarek J

Mon Sep 29 00:00:00 EDT 2014

Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.

The Journal of cell biology

Kong D,Farmer V,Shukla A,James J,Gruskin R,Kiriyama S,Loncarek J

Mon Sep 29 00:00:00 EDT 2014

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.

Osteoarthritis and cartilage

Thompson CL,Chapple JP,Knight MM

Sat Mar 01 00:00:00 EST 2014

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.

Osteoarthritis and cartilage

Thompson CL,Chapple JP,Knight MM

Sat Mar 01 00:00:00 EST 2014

Basal body proteins regulate Notch signaling through endosomal trafficking.

Journal of cell science

Leitch CC,Lodh S,Prieto-Echagüe V,Badano JL,Zaghloul NA

Sun Jun 01 00:00:00 EDT 2014

Basal body proteins regulate Notch signaling through endosomal trafficking.

Journal of cell science

Leitch CC,Lodh S,Prieto-Echagüe V,Badano JL,Zaghloul NA

Sun Jun 01 00:00:00 EDT 2014

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

Human molecular genetics

Zhou X,Fan LX,Li K,Ramchandran R,Calvet JP,Li X

Sat Mar 15 00:00:00 EDT 2014

SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.

Human molecular genetics

Zhou X,Fan LX,Li K,Ramchandran R,Calvet JP,Li X

Sat Mar 15 00:00:00 EDT 2014

Primary cilia in the developing pig testis.

Cell and tissue research

Ou Y,Dores C,Rodriguez-Sosa JR,van der Hoorn FA,Dobrinski I

Sat Nov 01 00:00:00 EDT 2014

Primary cilia in the developing pig testis.

Cell and tissue research

Ou Y,Dores C,Rodriguez-Sosa JR,van der Hoorn FA,Dobrinski I

Sat Nov 01 00:00:00 EDT 2014

Primary cilia in the developing pig testis.

Cell and tissue research

Ou Y,Dores C,Rodriguez-Sosa JR,van der Hoorn FA,Dobrinski I

Sat Nov 01 00:00:00 EDT 2014

Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.

Molecular biology of the cell

Aguilar A,Becker L,Tedeschi T,Heller S,Iomini C,Nachury MV

Sun Jun 15 00:00:00 EDT 2014

Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.

Molecular biology of the cell

Aguilar A,Becker L,Tedeschi T,Heller S,Iomini C,Nachury MV

Sun Jun 15 00:00:00 EDT 2014

RFX7 is required for the formation of cilia in the neural tube.

Mechanisms of development

Manojlovic Z,Earwood R,Kato A,Stefanovic B,Kato Y

Thu May 01 00:00:00 EDT 2014

RFX7 is required for the formation of cilia in the neural tube.

Mechanisms of development

Manojlovic Z,Earwood R,Kato A,Stefanovic B,Kato Y

Thu May 01 00:00:00 EDT 2014

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.

eLife

Wang W,Wu T,Kirschner MW

Tue Aug 19 00:00:00 EDT 2014

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.

eLife

Wang W,Wu T,Kirschner MW

Tue Aug 19 00:00:00 EDT 2014

A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.

PLoS genetics

Swiderski RE,Nakano Y,Mullins RF,Seo S,Bánfi B

Wed Oct 01 00:00:00 EDT 2014

A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.

PLoS genetics

Swiderski RE,Nakano Y,Mullins RF,Seo S,Bánfi B

Wed Oct 01 00:00:00 EDT 2014

BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.

PloS one

Leitch CC,Zaghloul NA

Thu Aug 13 00:00:00 EDT 2015

BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.

PloS one

Leitch CC,Zaghloul NA

Thu Aug 13 00:00:00 EDT 2015

Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.

Nature communications

Veleri S,Manjunath SH,Fariss RN,May-Simera H,Brooks M,Foskett TA,Gao C,Longo TA,Liu P,Nagashima K,Rachel RA,Li T,Dong L,Swaroop A

Fri Jun 20 00:00:00 EDT 2014

Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.

Nature communications

Veleri S,Manjunath SH,Fariss RN,May-Simera H,Brooks M,Foskett TA,Gao C,Longo TA,Liu P,Nagashima K,Rachel RA,Li T,Dong L,Swaroop A

Fri Jun 20 00:00:00 EDT 2014

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.

Nature communications

Kim H,Xu H,Yao Q,Li W,Huang Q,Outeda P,Cebotaru V,Chiaravalli M,Boletta A,Piontek K,Germino GG,Weinman EJ,Watnick T,Qian F

Tue Nov 18 00:00:00 EST 2014

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.

Nature communications

Kim H,Xu H,Yao Q,Li W,Huang Q,Outeda P,Cebotaru V,Chiaravalli M,Boletta A,Piontek K,Germino GG,Weinman EJ,Watnick T,Qian F

Tue Nov 18 00:00:00 EST 2014

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.

PloS one

Lee JY,Hong WJ,Majeti R,Stearns T

Tue Nov 18 00:00:00 EST 2014

Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.

PloS one

Lee JY,Hong WJ,Majeti R,Stearns T

Tue Nov 18 00:00:00 EST 2014

Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division.

eLife

Mora-Bermúdez F,Matsuzaki F,Huttner WB

Fri Jul 04 00:00:00 EDT 2014

Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division.

eLife

Mora-Bermúdez F,Matsuzaki F,Huttner WB

Fri Jul 04 00:00:00 EDT 2014

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Cell

Mukhopadhyay S,Wen X,Ratti N,Loktev A,Rangell L,Scales SJ,Jackson PK

Thu Jan 17 00:00:00 EST 2013

The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.

Cell

Mukhopadhyay S,Wen X,Ratti N,Loktev A,Rangell L,Scales SJ,Jackson PK

Thu Jan 17 00:00:00 EST 2013

Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.

Cell

Paridaen JT,Wilsch-Bräuninger M,Huttner WB

Thu Oct 10 00:00:00 EDT 2013

Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.

Cell

Paridaen JT,Wilsch-Bräuninger M,Huttner WB

Thu Oct 10 00:00:00 EDT 2013

Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.

Cell

Paridaen JT,Wilsch-Bräuninger M,Huttner WB

Thu Oct 10 00:00:00 EDT 2013

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

Science (New York, N.Y.)

Bhogaraju S,Cajanek L,Fort C,Blisnick T,Weber K,Taschner M,Mizuno N,Lamla S,Bastin P,Nigg EA,Lorentzen E

Fri Aug 30 00:00:00 EDT 2013

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

Science (New York, N.Y.)

Bhogaraju S,Cajanek L,Fort C,Blisnick T,Weber K,Taschner M,Mizuno N,Lamla S,Bastin P,Nigg EA,Lorentzen E

Fri Aug 30 00:00:00 EDT 2013

Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.

Nature methods

Su S,Phua SC,DeRose R,Chiba S,Narita K,Kalugin PN,Katada T,Kontani K,Takeda S,Inoue T

Fri Nov 01 00:00:00 EDT 2013

Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.

Nature methods

Su S,Phua SC,DeRose R,Chiba S,Narita K,Kalugin PN,Katada T,Kontani K,Takeda S,Inoue T

Fri Nov 01 00:00:00 EDT 2013

Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.

The Journal of clinical investigation

Drivas TG,Holzbaur EL,Bennett J

Tue Oct 01 00:00:00 EDT 2013

Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.

The Journal of clinical investigation

Drivas TG,Holzbaur EL,Bennett J

Tue Oct 01 00:00:00 EDT 2013

CCDC41 is required for ciliary vesicle docking to the mother centriole.

Proceedings of the National Academy of Sciences of the United States of America

Joo K,Kim CG,Lee MS,Moon HY,Lee SH,Kim MJ,Kweon HS,Park WY,Kim CH,Gleeson JG,Kim J

Tue Apr 09 00:00:00 EDT 2013

CCDC41 is required for ciliary vesicle docking to the mother centriole.

Proceedings of the National Academy of Sciences of the United States of America

Joo K,Kim CG,Lee MS,Moon HY,Lee SH,Kim MJ,Kweon HS,Park WY,Kim CH,Gleeson JG,Kim J

Tue Apr 09 00:00:00 EDT 2013

Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.

American journal of human genetics

Davidson AE,Schwarz N,Zelinger L,Stern-Schneider G,Shoemark A,Spitzbarth B,Gross M,Laxer U,Sosna J,Sergouniotis PI,Waseem NH,Wilson R,Kahn RA,Plagnol V,Wolfrum U,Banin E,Hardcastle AJ,Cheetham ME,Sharon D,Webster AR

Thu Aug 08 00:00:00 EDT 2013

Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.

American journal of human genetics

Thu Aug 08 00:00:00 EDT 2013

Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.

American journal of human genetics

Halbritter J,Bizet AA,Schmidts M,Porath JD,Braun DA,Gee HY,McInerney-Leo AM,Krug P,Filhol E,Davis EE,Airik R,Czarnecki PG,Lehman AM,Trnka P,Nitschké P,Bole-Feysot C,Schueler M,Knebelmann B,Burtey S,Szabó AJ,Tory K,Leo PJ,Gardiner B,McKenzie FA,Zankl A,Brown MA,Hartley JL,Maher ER,Li C,Leroux MR,Scambler PJ,Zhan SH,Jones SJ,Kayserili H,Tuysuz B,Moorani KN,Constantinescu A,Krantz ID,Kaplan BS,Shah JV,Hurd TW,Doherty D,Katsanis N,Duncan EL,Otto EA,Beales PL,Mitchison HM,Saunier S,Hildebrandt F

Thu Nov 07 00:00:00 EST 2013

Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.

American journal of human genetics

Thu Nov 07 00:00:00 EST 2013

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.

The Journal of cell biology

Kuhns S,Schmidt KN,Reymann J,Gilbert DF,Neuner A,Hub B,Carvalho R,Wiedemann P,Zentgraf H,Erfle H,Klingmüller U,Boutros M,Pereira G

Mon Feb 18 00:00:00 EST 2013

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.

The Journal of cell biology

Kuhns S,Schmidt KN,Reymann J,Gilbert DF,Neuner A,Hub B,Carvalho R,Wiedemann P,Zentgraf H,Erfle H,Klingmüller U,Boutros M,Pereira G

Mon Feb 18 00:00:00 EST 2013

VDAC3 and Mps1 negatively regulate ciliogenesis.

Cell cycle (Georgetown, Tex.)

Majumder S,Fisk HA

Fri Mar 01 00:00:00 EST 2013

VDAC3 and Mps1 negatively regulate ciliogenesis.

Cell cycle (Georgetown, Tex.)

Majumder S,Fisk HA

Fri Mar 01 00:00:00 EST 2013

Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.

Human molecular genetics

Liu C,Lin C,Whitaker DT,Bakeri H,Bulgakov OV,Liu P,Lei J,Dong L,Li T,Swaroop A

Sat Jun 01 00:00:00 EDT 2013

Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.

Human molecular genetics

Liu C,Lin C,Whitaker DT,Bakeri H,Bulgakov OV,Liu P,Lei J,Dong L,Li T,Swaroop A

Sat Jun 01 00:00:00 EDT 2013

The ciliary protein Ftm is required for ventricular wall and septal development.

PloS one

Gerhardt C,Lier JM,Kuschel S,Rüther U

Tue Sep 10 00:00:00 EDT 2013

The ciliary protein Ftm is required for ventricular wall and septal development.

PloS one

Gerhardt C,Lier JM,Kuschel S,Rüther U

Tue Sep 10 00:00:00 EDT 2013

Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys.

American journal of physiology. Renal physiology

Kim JI,Kim J,Jang HS,Noh MR,Lipschutz JH,Park KM

Wed May 15 00:00:00 EDT 2013

Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys.

American journal of physiology. Renal physiology

Kim JI,Kim J,Jang HS,Noh MR,Lipschutz JH,Park KM

Wed May 15 00:00:00 EDT 2013

Visualizing renal primary cilia.

Nephrology (Carlton, Vic.)

Deane JA,Verghese E,Martelotto LG,Cain JE,Galtseva A,Rosenblum ND,Watkins DN,Ricardo SD

Fri Mar 01 00:00:00 EST 2013

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.

The Journal of cell biology

Li Y,Zhang Q,Wei Q,Zhang Y,Ling K,Hu J

Mon Nov 12 00:00:00 EST 2012

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.

The Journal of cell biology

Li Y,Zhang Q,Wei Q,Zhang Y,Ling K,Hu J

Mon Nov 12 00:00:00 EST 2012

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.

The Journal of cell biology

Li Y,Zhang Q,Wei Q,Zhang Y,Ling K,Hu J

Mon Nov 12 00:00:00 EST 2012

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.

The Journal of cell biology

Li Y,Zhang Q,Wei Q,Zhang Y,Ling K,Hu J

Mon Nov 12 00:00:00 EST 2012

Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination.

Development (Cambridge, England)

Wilsch-Bräuninger M,Peters J,Paridaen JT,Huttner WB

Sun Jan 01 00:00:00 EST 2012

Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination.

Development (Cambridge, England)

Wilsch-Bräuninger M,Peters J,Paridaen JT,Huttner WB

Sun Jan 01 00:00:00 EST 2012

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.

Nature cell biology

Chih B,Liu P,Chinn Y,Chalouni C,Komuves LG,Hass PE,Sandoval W,Peterson AS

Sun Dec 18 00:00:00 EST 2011

A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.

Nature cell biology

Chih B,Liu P,Chinn Y,Chalouni C,Komuves LG,Hass PE,Sandoval W,Peterson AS

Sun Dec 18 00:00:00 EST 2011

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.

PLoS genetics

Seo S,Zhang Q,Bugge K,Breslow DK,Searby CC,Nachury MV,Sheffield VC

Tue Nov 01 00:00:00 EDT 2011

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.

PLoS genetics

Seo S,Zhang Q,Bugge K,Breslow DK,Searby CC,Nachury MV,Sheffield VC

Tue Nov 01 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: ADP-ribosylation factor like GTPase 13B; ADP-ribosylation factor-like 13B; ADP-ribosylation factor-like 2-like 1; ADP-ribosylation factor-like protein 13B; ADP-ribosylation factor-like protein 2-like 1; ARL2-like protein 1; Protein hennin

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Gene Aliases: A530097K21Rik; A930014M17Rik; ARL13B; ARL2L1; C530009C10Rik; hnn; JBTS8

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UniProt ID: (Human) Q3SXY8, (Mouse) Q640N2

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Entrez Gene ID: (Dog) 487934, (Human) 200894, (Rat) 304037, (Mouse) 68146

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Function(s)

protein binding GTP binding nucleotide binding

Process(es)

heart looping smoothened signaling pathway small GTPase mediated signal transduction dorsal/ventral pattern formation neural tube patterning interneuron migration from the subpallium to the cortex formation of radial glial scaffolds nonmotile primary cilium assembly cilium assembly left/right axis specification determination of left/right symmetry multicellular organism development

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ARL13B Polyclonal Antibody

ARL13B Antibody (17711-1-AP) in ICC/IF

Product Details

17711-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

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Published species

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Type

Immunogen

Conjugate

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