Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Alomone Labs, LTD
B1 Bradykinin Receptor (BDKRB1) Polyclonal Antibody
FIGURE: 1 / 2
B1 Bradykinin Receptor (BDKRB1) Antibody (ABR-011-200UL) in IHC (F)
Expression of B1bradykinin receptorin rat CNS - Immunohistochemical staining of frozen rat brainsection (A & B) and cerebellum (C) using Anti-B1Bradykinin Receptor (BDKRB1) Antibody (#ABR-011), (1:50). BKR1is expressed in neuronal cells of the amygdala (A) and hippocampus (CA1) (B) as well as in the axons of Purkinje cells in the cerebellum (arrowheads on C). Hoechst 33342 is used as the counterstain.
Product Details
ABR-011-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KEAS RTR*SG GPKGS K, corresponding to amino acid residues 243-257 of rat B1R with replacement of cysteine 250 (C250) with serine (*S), 3rd intracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: B1 bradykinin receptor; B1R; Bk b1 receptor; BK-1 receptor; BKRB1; bradykinin B1 receptor; bradykinin receptor, beta 1; KB1; kinin B1; Kinin B1 receptor
Gene Aliases: B1BKR; B1R; Bdkrb; Bdkrb1; BKR; BKR1; BRADYB1
UniProt ID: (Rat) P97583, (Mouse) Q61125
Entrez Gene ID: (Rat) 81509, (Mouse) 12061
negative regulation of protein phosphorylation
positive regulation of leukocyte migration
inflammatory response
G-protein coupled receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
response to mechanical stimulus
cell migration
sensory perception of pain
negative regulation of cell growth
response to lipopolysaccharide
negative regulation of blood pressure
positive regulation of release of sequestered calcium ion into cytosol
response to stress
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support