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Invitrogen
BAF57 Recombinant Rabbit Monoclonal Antibody (23GB2810)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
BAF57 Antibody (MA5-53296) in ICC/IF
Immunocytochemistry analysis of BAF57 in HAP-1 cells. Nuclei were stained blue with DAPI; BAF57 recombinant monoclonal antibody (Product # MA5-53296) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Product Details
MA5-53296
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB2810
Immunogen
A synthesized peptide derived from human BAF57/SMARCE1 (1-59AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAF57; BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; SMARCE 1; SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Gene Aliases: 2810417B20Rik; 5830412H02Rik; 9030408N19Rik; Baf27; BAF57; CSS5; RGD1304726; SMARCE1
UniProt ID: (Human) Q969G3, (Rat) Q56A18, (Mouse) O54941
Entrez Gene ID: (Human) 6605, (Rat) 303518, (Mouse) 57376
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
chromatin binding
transcription coactivator activity
RNA binding
protein binding
N-acetyltransferase activity
ligand-dependent nuclear receptor binding
nucleosomal DNA binding
protein N-terminus binding
DNA binding
chromatin/chromatin-binding, or -regulatory protein
nucleosome disassembly
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
covalent chromatin modification
neurogenesis
ATP-dependent chromatin remodeling
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
spermatid development
brain development
metabolic process
nervous system development
chromatin modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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