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Product Details
H00116071-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1B11
Immunogen
BATF2 (AAH12330, 1 a.a. approximately 189 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MDCASCSAPG LLGCWDQAEG LLGPGPQGQH GCREQLELFQ TPGSCYPAQP LSPGPQPHDS PSLLQCPLPS LSLGPAVVAE PPVQLSPSPL LFASHTGSSL QGSSSKLSAL QPSLTAQTAP PQPLELEHPT RGKLGSSPDN PSSALGLARL QSREHKPALS AATWQGLVVD PSPHPLLAFP LLSSAQVHF
Target Information
BATF2 (basic leucine zipper transcription factor, ATF-like 2) is a 274 amino acid protein that localizes to the nucleus and contains one bZIP domain, suggesting that it may be involved in transcriptional regulation. The gene encoding BATF2, which is expressed as multiple alternatively spliced isoforms, is located on human chromosome 11. With approximately 135 million base pairs and 1, 400 genes, chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-ATF-2; basic leucine zipper transcription factor, ATF-like 2; Basic leucine zipper transcriptional factor ATF-like 2; MGC20410; SARI; Suppressor of AP-1 regulated by IFN
Gene Aliases: BATF2; SARI
UniProt ID: (Human) Q8N1L9
Entrez Gene ID: (Human) 116071
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