Proteintech

CDK4 Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (16)

CDK4 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 16

CDK4 Antibody (11026-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using CDK4 antibody (Product # 11026-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CDK4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CDK4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11026-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 293 publications 293 publications

Immunohistochemistry (IHC)

View 19 publications 19 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:20-1:200

View 4 publications 4 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 5 publications 5 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Not applicable (N/A)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDK4 Fusion Protein Ag1505 (1-303 aa encoded by BC010153)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATSRYEPV AEIGVGAYGT VYKARDPHSG HFVALKSVRV PNGGGGGGGL PISTVREVAL LRRLEAFEHP NVVRLMDVCA TSRTDREIKV TLVFEHVDQD LRTYLDKAPP PGLPAETIKD LMRQFLRGLD FLHANCIVHR DLKPENILVT SGGTVKLADF GLARIYSYQM ALTPVVVTLW YRAPEVLLQS TYATPVDMWS VGCIFAEMFR RKPLFCGNSE ADQLGKIFDL IGLPPEDDWP RDVSLPRGAF PPRGPRPVQS VVPEMEESGA QLLLEMLTFN PHKRISAFRA LQHSYLHKDE GNPE (1-303 aa encoded by BC010153)

Target Information

CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Laser-triggered intelligent drug delivery and anti-cancer photodynamic therapy using platelets as the vehicle.

Platelets

Li QR,Xu HZ,Xiao RC,Liu B,Ma TQ,Yu TT,Li LG,Wang MF,Zhao L,Chen X,Li TF

Fri Dec 01 00:00:00 EST 2023

The Natural Alkaloid (-)-N-Hydroxyapiosporamide Suppresses Colorectal Tumor Progression as an NF-κB Pathway Inhibitor by Targeting the TAK1-TRAF6 Complex.

Journal of natural products

Feng L,Shang RR,Wang XJ,Li L,Li X,Gong YX,Shi LY,Wang JW,Qian ZY,Tan NH,Wang Z

Fri Jun 23 00:00:00 EDT 2023

Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells.

Chemico-biological interactions

Gui Z,Li J,Li J,Li X,Chen L,Ma Z,Tang X,Gong X,Chai X,Lu F,Li M,Ma H,Li X,Ye X

Sat Apr 01 00:00:00 EDT 2023

Effects of Ginsenoside Rg1 on the Biological Behavior of Human Amnion-Derived Mesenchymal Stem/Stromal Cells (hAD-MSCs).

Stem cells international

Ling L,Shu H,Huang Y,Hou J,Hua Y

Tue Feb 28 00:00:00 EST 2023

ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells.

Chemico-biological interactions

Gao Y,Liu T,Liu J,Yang Y,Sun K,Li Z,Zhai X,Zuo D

Sat Jul 01 00:00:00 EDT 2023

Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.

Oncology reports

Shen C,Chen Z,Zhang Y,Xu W,Peng R,Jiang J,Zuo W,Fan Y,Zheng B

Sun Jan 01 00:00:00 EST 2023

Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.

Cancers

Rahman KU,Yang S,Azam N,Yuan Z,Yu J,Zhao C,Feng B

Sat Mar 11 00:00:00 EST 2023

Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.

Molecules (Basel, Switzerland)

He Y,Luo M,Lei S,Zeng Z,Chen T,Wu Y,Wang D,Wang L,Wang L

Sun Feb 12 00:00:00 EST 2023

Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Sun Y,Weng J,Chen X,Ma S,Zhang Y,Zhang F,Zhang Z,Wang F,Shao J,Zheng S

Thu Jun 01 00:00:00 EDT 2023

Therapeutic efficacy of a MMAE-based anti-DR5 drug conjugate Oba01 in preclinical models of pancreatic cancer.

Cell death & disease

Zheng C,Zhou D,Li W,Duan Y,Xu M,Liu J,Cheng J,Xiao Y,Xiao H,Gan T,Liang J,Zheng D,Wang L,Zhang S

Sat Apr 29 00:00:00 EDT 2023

P16^INK4a Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy.

Oxidative medicine and cellular longevity

Sun J,Zhou L,Yang T,Deng B,Bao Y,Gu L,Wang H,Wang L

Tue Mar 07 00:00:00 EST 2023

Low-dose graphene oxide promotes tumor cells proliferation by activating PI3K-AKT-mTOR signaling via cellular membrane protein integrin αV.

Environmental pollution (Barking, Essex : 1987)

Zheng Z,Halifu A,Ma J,Liu L,Fu Q,Yi B,Du E,Tian D,Xu Y,Zhang Z,Zhu J

Tue Aug 01 00:00:00 EDT 2023

HDAC inhibitor chidamide overcomes drug resistance in chronic myeloid leukemia with the T315i mutation through the Akt-autophagy pathway.

Human cell

Yin L,Zhang Q,Xie S,Cheng Z,Li R,Zhu H,Yu Q,Yuan H,Wang C,Peng H,Zhang G

Sat Jul 01 00:00:00 EDT 2023

The role of miR-369-3p in proliferation and differentiation of preadipocytes in Aohan fine-wool sheep.

Archives animal breeding

Xue S,Liu K,Zhao L,Zhou L,Gao X,Liu L,Liu N,He J

Mon Jul 03 00:00:00 EDT 2023

Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1.

British journal of pharmacology

Chen L,Liang B,Xia S,Wang F,Li Z,Shao J,Zhang Z,Chen A,Zheng S,Zhang F

Sun Oct 01 00:00:00 EDT 2023

The location of estrogen receptor variant ER-α36 is associated with the invasion of glioblastoma.

Steroids

Li H,Ge N,Guan X,Han C,Li Y,Shen L,Chen M,Zhang B,Qu C,Zou W

Thu Jun 01 00:00:00 EDT 2023

The long non-coding RNA PANDAR regulates cell proliferation and epithelial-to-mesenchymal transition in glioma.

Histology and histopathology

Guo J,Xiao D,Lin Z,Sui C

Wed Feb 01 00:00:00 EST 2023

Proline-rich 11 (PRR11) promotes the progression of cutaneous squamous cell carcinoma by activating the EGFR signaling pathway.

Molecular carcinogenesis

Wang S,Zhang X,Lei H,Song L,Huang Y,Kang T,Zhang M,Wang N,Yang P,Feng S,Wang J,Bai R,Wang N,Wang W,Zheng Y

Mon May 01 00:00:00 EDT 2023

5-Fluorouracil Combined with Rutaecarpine Synergistically Suppresses the Growth of Colon Cancer Cells by Inhibiting STAT3.

Drug design, development and therapy

Yu Z,Chan S,Wang X,Sun R,Wang M,Wang Z,Zuo X,Chen J,Zhang H,Chen W

Fri Apr 07 00:00:00 EDT 2023

Inhibition of STAT3 signaling as critical molecular event in HUC-MSCs suppressed Glioblastoma Cells.

Journal of Cancer

Wang M,Zhang Y,Liu M,Jia Y,He J,Xu X,Shi H,Zhang Y,Zhang J,Liu Y

Sat Apr 15 00:00:00 EDT 2023

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.

eLife

Spens AE,Sutliff NA,Bennett SR,Campbell AE,Tapscott SJ

Mon Apr 24 00:00:00 EDT 2023

Sanggenon C inhibits cell proliferation and induces apoptosis by regulating the MIB1/DAPK1 axis in glioblastoma.

MedComm

Chang H,Hou J,Shao Y,Xu M,Weng X,Du Y,Shi J,Zhang L,Cui H

Tue Aug 01 00:00:00 EDT 2023

RPL11 promotes non-small cell lung cancer cell proliferation by regulating endoplasmic reticulum stress and cell autophagy.

BMC molecular and cell biology

Chen J,Lei C,Zhang H,Huang X,Yang Y,Liu J,Jia Y,Shi H,Zhang Y,Zhang J,Du J

Fri Mar 03 00:00:00 EST 2023

Activating the Hippo pathway by nevadensin overcomes Yap-drived resistance to sorafenib in hepatocellular carcinoma.

Discover. Oncology

Shi H,Zou Y,Wang X,Wang G,Gao Y,Yi F,Xu J,Yin Y,Li D,Li M

Sat May 27 00:00:00 EDT 2023

Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.

PloS one

Zhu Y,Sun W,Jiang X,Bai R,Luo Y,Gao Y,Li S,Huang Z,Gong Y,Xie C

Fri Feb 03 00:00:00 EST 2023

Influence of cyclin D1 splicing variants expression on breast cancer chemoresistance via CDK4/CyclinD1-pRB-E2F1 pathway.

Journal of cellular and molecular medicine

Wang J,Zhang J,Ma Q,Zhang S,Ma F,Su W,Zhang T,Xie X,Di C

Sat Apr 01 00:00:00 EDT 2023

Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence.

Pharmacological research

Zhao D,Gao Y,Su Y,Zhou Y,Yang T,Li Y,Wang Y,Sun Y,Chen L,Zhang F,Zhang Z,Wang F,Shao J,Zheng S

Sun Jan 01 00:00:00 EST 2023

MicroRNA-1205 Suppresses Hepatocellular Carcinoma Cell Proliferation via a CSNK2B/CDK4 Axis.

Technology in cancer research & treatment

Li X,Xie S,Xia Q,Yan J,Chen S,Shen J

Wed Jan 11 00:00:00 EST 2023

NEK2 overexpression aggravates IL-22-induced keratinocyte proliferation and cytokine level increases and IMQ-induced psoriasis-like dermatitis.

Biochimica et biophysica acta. Molecular cell research

Peng Y,Zhang Y,Luo M,Pan Y,Zhou R,Yan YN,Yi T,Luo F,Wang B,Wang L,Ran C,Wang H

Fri Dec 01 00:00:00 EST 2023

Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.

International journal of molecular sciences

Shi Q,Li S,Lyu Q,Zhang S,Bai Y,Ma J

Wed Feb 01 00:00:00 EST 2023

Targeted Protein Degradation Induced by HEMTACs Based on HSP90.

Journal of medicinal chemistry

Li Z,Ma S,Zhang L,Zhang S,Ma Z,Du L,Li M

Thu Jan 12 00:00:00 EST 2023

Targeted Protein Degradation Induced by HEMTACs Based on HSP90.

Journal of medicinal chemistry

Li Z,Ma S,Zhang L,Zhang S,Ma Z,Du L,Li M

Thu Jan 12 00:00:00 EST 2023

Targeted Protein Degradation Induced by HEMTACs Based on HSP90.

Journal of medicinal chemistry

Li Z,Ma S,Zhang L,Zhang S,Ma Z,Du L,Li M

Thu Jan 12 00:00:00 EST 2023

BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.

Cell death & disease

Li M,Wei Y,Liu Y,Wei J,Zhou X,Duan Y,Chen S,Xue C,Zhan Y,Zheng L,Deng H,Tang F,Fan S,Xiong W,Li G,Tan M,Zhou M

Tue Feb 14 00:00:00 EST 2023

Upregulation of HCFC1 expression promoted hepatocellular carcinoma progression through inhibiting cell cycle arrest and correlated with immune infiltration.

Journal of Cancer

Wang H,Yu M,Yang C,Li Q

Thu Jun 08 00:00:00 EDT 2023

Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.

Frontiers in pharmacology

Bai Y,Chen J,Hu W,Wang L,Wu Y,Yu S

Wed Apr 13 00:00:00 EDT 2022

Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.

International journal of biological sciences

Li J,Yang T,Wang Q,Li Y,Wu H,Zhang M,Qi H,Zhang H,Li J

Tue Jul 12 00:00:00 EDT 2022

Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.

Journal of translational medicine

Wang J,Zhou L,Chen B,Yu Z,Zhang J,Zhang Z,Hu C,Bai Y,Ruan X,Wang S,Ouyang J,Wu A,Zhao X

Mon Jan 31 00:00:00 EST 2022

Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.

Drug delivery

Li QR,Xu HZ,Xiao RC,Liu Y,Tang JM,Li J,Yu TT,Liu B,Li LG,Wang MF,Han N,Xu YH,Wang C,Komatsu N,Zhao L,Peng XC,Li TF,Chen X

Thu Dec 01 00:00:00 EST 2022

Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.

Drug delivery

Li QR,Xu HZ,Xiao RC,Liu Y,Tang JM,Li J,Yu TT,Liu B,Li LG,Wang MF,Han N,Xu YH,Wang C,Komatsu N,Zhao L,Peng XC,Li TF,Chen X

Thu Dec 01 00:00:00 EST 2022

Dematin inhibits glioblastoma malignancy through RhoA-mediated CDKs downregulation and cytoskeleton remodeling.

Experimental cell research

Wang M,Chen B,Zhang W,Zhang F,Qiu Y,Lin Y,Yang S

Mon Aug 01 00:00:00 EDT 2022

Lithocholic Acid Alleviates Deoxynivalenol-Induced Lethal Cholesterol Metabolic Abnormalities in IPI-2I Cells.

Metabolites

Li Y,Gu F,Gu H,Hu P,Liu HX,Cai D

Sun Jul 17 00:00:00 EDT 2022

C/EBPα Epigenetically Modulates TFF1 Expression via mC-6 Methylation in the Jejunum Inflammation Induced by a Porcine Coronavirus.

Frontiers in immunology

Qu H,Zong Q,Wang H,Wu S,Cai D,Bao W

Tue Jun 14 00:00:00 EDT 2022

miR-340-5p affects oral squamous cell carcinoma (OSCC) cells proliferation and invasion by targeting endoplasmic reticulum stress proteins.

European journal of pharmacology

Ou D,Wu Y,Zhang J,Liu J,Liu Z,Shao M,Guo X,Cui S

Tue Apr 05 00:00:00 EDT 2022

SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia.

Redox biology

Archer SL,Dasgupta A,Chen KH,Wu D,Baid K,Mamatis JE,Gonzalez V,Read A,Bentley RE,Martin AY,Mewburn JD,Dunham-Snary KJ,Evans GA,Levy G,Jones O,Al-Qazazi R,Ring B,Alizadeh E,Hindmarch CC,Rossi J,Lima PD,Falzarano D,Banerjee A,Colpitts CC

Thu Dec 01 00:00:00 EST 2022

Integrative and Comprehensive Pan-Cancer Analysis of Lymphocyte-Specific Protein Tyrosine Kinase in Human Tumors.

International journal of molecular sciences

Han M,Li Y,Guo Y,Zhu W,Jiang J

Sun Nov 13 00:00:00 EST 2022

Rutaecarpine suppresses the proliferation and metastasis of colon cancer cells by regulating the STAT3 signaling.

Journal of Cancer

Chan S,Sun R,Tu X,Guo M,Yuan Q,Yu Z,Wang Z,Hong S,Han W,Zou B,Li Z,Zhang H,Chen W

Wed Feb 16 00:00:00 EST 2022

Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.

European journal of medicinal chemistry

Liang JJ,Yu WL,Yang L,Qin KM,Yin YP,Li D,Ni YH,Yan JJ,Zhong YX,Deng ZX,Hong K

Sun Jun 05 00:00:00 EDT 2022

HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.

Frontiers in oncology

Wang H,Chen Y,Yuan Q,Chen L,Dai P,Li X

Tue Jan 03 00:00:00 EST 2023

Discovery of Small-Molecule Degraders of the CDK9-Cyclin T1 Complex for Targeting Transcriptional Addiction in Prostate Cancer.

Journal of medicinal chemistry

Li J,Liu T,Song Y,Wang M,Liu L,Zhu H,Li Q,Lin J,Jiang H,Chen K,Zhao K,Wang M,Zhou H,Lin H,Luo C

Thu Aug 25 00:00:00 EDT 2022

Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma.

Cell death discovery

Wang F,Cheng C,Wang X,Chen F,Li H,Zhou Y,Wang Y,Hu X,Kong P,Zhang L,Cheng X,Cui Y

Fri Apr 08 00:00:00 EDT 2022

Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma.

Cell death discovery

Wang F,Cheng C,Wang X,Chen F,Li H,Zhou Y,Wang Y,Hu X,Kong P,Zhang L,Cheng X,Cui Y

Fri Apr 08 00:00:00 EDT 2022

Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.

Food & function

Lu H,Yin H,Qu L,Ma X,Fu R,Fan D

Mon Apr 04 00:00:00 EDT 2022

Chrysin Ameliorates Influenza Virus Infection in the Upper Airways by Repressing Virus-Induced Cell Cycle Arrest and Mitochondria-Dependent Apoptosis.

Frontiers in immunology

Liu Y,Song X,Li C,Hu H,Li W,Wang L,Hu J,Liao C,Liang H,He Z,Ye L

Tue Apr 19 00:00:00 EDT 2022

SPTBN2 Promotes the Progression of Thyroid Cancer by Accelerating G1/S Transition and Inhibiting Apoptosis.

Disease markers

Zhou X,Lin L,Qi Y,Xu M,Xu Q,Wang Y,Qu J

Tue Aug 16 00:00:00 EDT 2022

Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.

Frontiers in pharmacology

Liu M,Hu T,Gou W,Chang H,Li Y,Li Y,Zuo D,Hou W,Jiao S

Fri Feb 17 00:00:00 EST 2023

Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway.

BMC molecular and cell biology

Zhang H,Liu J,Dang Q,Wang X,Chen J,Lin X,Yang N,Du J,Shi H,Liu Y,Han J

Wed Nov 16 00:00:00 EST 2022

NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.

Aging

Zhao R,Ge Y,Gong Y,Li B,Xiao B,Zuo S

Fri Nov 11 00:00:00 EST 2022

HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway.

Journal of experimental & clinical cancer research : CR

Guo K,Ma Z,Zhang Y,Han L,Shao C,Feng Y,Gao F,Di S,Zhang Z,Zhang J,Tabbò F,Ekman S,Suda K,Cappuzzo F,Han J,Li X,Yan X

Fri Mar 11 00:00:00 EST 2022

P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway.

Biochemical and biophysical research communications

Shi J,Sun J,Liu L,Shan T,Meng H,Yang T,Wang S,Wei T,Chen B,Ma Y,Wang Q,Wang H,Liu J,Wang L

Sat Mar 05 00:00:00 EST 2022

Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.

International journal of molecular sciences

Ma XY,Xu HQ,Zhao JF,Ruan Y,Chen B

Sat Nov 26 00:00:00 EST 2022

Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.

International journal of molecular sciences

Ma XY,Xu HQ,Zhao JF,Ruan Y,Chen B

Sat Nov 26 00:00:00 EST 2022

Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.

International journal of molecular sciences

Ma XY,Xu HQ,Zhao JF,Ruan Y,Chen B

Sat Nov 26 00:00:00 EST 2022

Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer.

International journal of molecular sciences

Ma XY,Xu HQ,Zhao JF,Ruan Y,Chen B

Sat Nov 26 00:00:00 EST 2022

HMGB1 induces radioresistance through PI3K/AKT/ATM pathway in esophageal squamous cell carcinoma.

Molecular biology reports

Zhang X,Zou N,Deng W,Song C,Yan K,Shen W,Zhu S

Thu Dec 01 00:00:00 EST 2022

SERPINA5 promotes tumour cell proliferation by modulating the PI3K/AKT/mTOR signalling pathway in gastric cancer.

Journal of cellular and molecular medicine

Fan M,Xiong X,Han L,Zhang L,Gao S,Liu L,Wang X,Huang C,Tong D,Yang J,Zhao L,Shao Y

Thu Sep 01 00:00:00 EDT 2022

Myeloid-derived growth factor deficiency exacerbates mitotic catastrophe of podocytes in glomerular disease.

Kidney international

Zhan P,Zhang Y,Shi W,Liu X,Qiao Z,Wang Z,Wang X,Wu J,Tang W,Sun Y,Zhang Y,Zhen J,Shang J,Liu M,Yi F

Thu Sep 01 00:00:00 EDT 2022

HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.

British journal of cancer

Zhang G,Tan R,Wan S,Yang R,Hu X,Zhao E,Ding X,Zhang J,Li B,Liang P,Cui H

Tue Nov 01 00:00:00 EDT 2022

Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.

Oncology reports

Wang T,Liu J,Huang X,Zhang C,Shangguan M,Chen J,Wu S,Chen M,Yang Z,Zhao S

Tue Nov 01 00:00:00 EDT 2022

Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells.

European journal of medicinal chemistry

Pan Z,Chen Y,Pang H,Wang X,Zhang Y,Xie X,He G

Tue Nov 15 00:00:00 EST 2022

Cyclin-dependent kinase 4/6 inhibitors suppress tumor growth in extramammary Paget's disease.

Cancer science

Kitamura S,Yanagi T,Maeda T,Ujiie H

Tue Feb 01 00:00:00 EST 2022

Ursolic Acid Derivative UA232 Promotes Tumor Cell Apoptosis by Inducing Endoplasmic Reticulum Stress and Lysosomal Dysfunction.

International journal of biological sciences

Gou W,Luo N,Yu B,Wu H,Wu S,Tian C,Guo J,Ning H,Bi C,Wei H,Hou W,Li Y

Thu Apr 14 00:00:00 EDT 2022

Paired box 8 facilitates the c-MYC related cell cycle progress in TP53-mutation uterine corpus endometrial carcinoma through interaction with DDX5.

Cell death discovery

Qiu P,Jie Y,Ma C,Chen H,Qin Y,Tu K,Wang L,Zhang Z

Tue Jun 07 00:00:00 EDT 2022

SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway.

Cancer cell international

Liu Z,Wang Q,Zhai G,Ke S,Yu X,Guo J

Sat Mar 19 00:00:00 EDT 2022

CDCA3 Predicts Poor Prognosis and Affects CD8⁺ T Cell Infiltration in Renal Cell Carcinoma.

Journal of oncology

Bai Y,Liao S,Yin Z,You B,Lu D,Chen Y,Chen D,Wu Y

Tue Oct 11 00:00:00 EDT 2022

Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway.

Molecules and cells

Li J,Li B,Bu Y,Zhang H,Guo J,Hu J,Zhang Y

Sat Apr 30 00:00:00 EDT 2022

Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway.

Molecules and cells

Li J,Li B,Bu Y,Zhang H,Guo J,Hu J,Zhang Y

Sat Apr 30 00:00:00 EDT 2022

Targeting cyclin-dependent kinases 4/6 inhibits survival of megakaryoblasts in acute megakaryoblastic leukaemia.

Leukemia research

Qi K,Hu X,Yu X,Cheng H,Wang C,Wang S,Wang Y,Li Y,Cao J,Pan B,Wu Q,Qiao J,Zeng L,Li Z,Xu K,Fu C

Thu Sep 01 00:00:00 EDT 2022

High expression of HOXA4 in patients with glioma indicates unfavorable clinical outcomes.

Cell cycle (Georgetown, Tex.)

Yu Z,Liu Z,Lian X,Cheng X,Liu B,Zhang B,Wang H,Wang J,Li A,Ren Z,Pang B,Qian R,Gao Y

Tue Nov 01 00:00:00 EDT 2022

A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin.

Journal of nanobiotechnology

Yang XX,Xu X,Wang MF,Xu HZ,Peng XC,Han N,Yu TT,Li LG,Li QR,Chen X,Wen Y,Li TF

Sat May 14 00:00:00 EDT 2022

NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma.

Acta pharmaceutica Sinica. B

Wei R,Cui X,Min J,Lin Z,Zhou Y,Guo M,An X,Liu H,Janz S,Gu C,Wang H,Yang Y

Mon Aug 01 00:00:00 EDT 2022

S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer.

Molecular cancer

Mo H,Liu X,Xue Y,Chen H,Guo S,Li Z,Wang S,Li C,Han J,Fu M,Song Y,Li D,Ma F

Tue Aug 30 00:00:00 EDT 2022

S6K1 amplification confers innate resistance to CDK4/6 inhibitors through activating c-Myc pathway in patients with estrogen receptor-positive breast cancer.

Molecular cancer

Mo H,Liu X,Xue Y,Chen H,Guo S,Li Z,Wang S,Li C,Han J,Fu M,Song Y,Li D,Ma F

Tue Aug 30 00:00:00 EDT 2022

Theaflavin-3,3'-Digallate from Black Tea Inhibits Neointima Formation Through Suppression of the PDGFRβ Pathway in Vascular Smooth Muscle Cells.

Frontiers in pharmacology

Wu Y,Chen M,Chen Z,Shu J,Zhang L,Hu J,Yu H,Huang K,Liang M

Sun Jul 31 00:00:00 EDT 2022

Extracellular matrix stiffness mediates radiosensitivity in a 3D nasopharyngeal carcinoma model.

Cancer cell international

Fang Y,Liang S,Gao J,Wang Z,Li C,Wang R,Yu W

Sat Nov 19 00:00:00 EST 2022

Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.

European journal of medicinal chemistry

Liang JJ,Yu WL,Yang L,Xie BH,Qin KM,Yin YP,Yan JJ,Gong S,Liu TY,Zhou HB,Hong K

Sat Feb 05 00:00:00 EST 2022

METTL1 drives tumor progression of bladder cancer via degrading ATF3 mRNA in an m⁷G-modified miR-760-dependent manner.

Cell death discovery

Xie H,Wang M,Yu H,Wang H,Ding L,Wang R,Luo W,Lu Z,Zheng Q,Ren L,Zhou Z,Su W,Xia L,Li G

Thu Nov 17 00:00:00 EST 2022

CDK4/6 Inhibition Enhances Oncolytic Virus Efficacy by Potentiating Tumor-Selective Cell Killing and T-cell Activation in Refractory Glioblastoma.

Cancer research

Xiao J,Liang J,Fan J,Hou P,Li X,Zhang H,Li K,Bu L,Li P,He M,Zhong Y,Guo L,Jia P,Xiao Q,Wu J,Peng H,Li C,Xing F,Guo D

Fri Sep 16 00:00:00 EDT 2022

NAT10 acetylates BCL-XL mRNA to promote the proliferation of multiple myeloma cells through PI3K-AKT pathway.

Frontiers in oncology

Zhang Y,Deng Z,Sun S,Xie S,Jiang M,Chen B,Gu C,Yang Y

Sun Nov 05 00:00:00 EDT 2023

Dissecting the genetic and microenvironmental factors of gastric tumorigenesis in mice.

Cell reports

Lu Z,Zhong A,Liu H,Zhang M,Chen X,Pan X,Wang M,Deng X,Gao L,Zhao L,Wang J,Yang Y,Zhang Q,Wu B,Zheng J,Wang Y,Song X,Liu K,Zhang W,Chen X,Yang K,Chen X,Zhao Y,Zhao C,Wang Y,Chen L,Zhou Z,Hu J,Liu Y,Chen C

Tue Oct 18 00:00:00 EDT 2022

Estrogen receptor variant ER-α36 facilitates estrogen signaling via EGFR in glioblastoma.

Cell biology international

Qu C,Wang C,Li H,Li Y,Han C,Tao X,Guan X,Zhang Y,Chen M,Liu J,Zou W

Tue Nov 01 00:00:00 EDT 2022

Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway.

Drug development research

Huang Z,Chen H,Tan P,Huang M,Shi H,Sun B,Cheng Y,Li T,Mou Z,Li Q,Fu W

Sun May 01 00:00:00 EDT 2022

Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway.

Drug development research

Huang Z,Chen H,Tan P,Huang M,Shi H,Sun B,Cheng Y,Li T,Mou Z,Li Q,Fu W

Sun May 01 00:00:00 EDT 2022

HECTD3 promotes gastric cancer progression by mediating the polyubiquitination of c-MYC.

Cell death discovery

Zhang G,Zhu Q,Yan X,Ci M,Zhao E,Hou J,Wan S,Lü M,Cui H

Sat Apr 09 00:00:00 EDT 2022

Hyperthermia inhibits growth of nasopharyngeal carcinoma through degradation of c-Myc.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

Li X,Duan S,Zheng Y,Yang Y,Wang L,Li X,Zhang Q,Thorne RF,Li W,Yang D

Mon Apr 04 00:00:00 EDT 2022

FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value.

Experimental cell research

Zheng C,Ren Z,Chen H,Yuan X,Suye S,Yin H,Zhou Z,Fu C

Thu Dec 15 00:00:00 EST 2022

FERMT1 contributes to the migration and invasion of nasopharyngeal carcinoma through epithelial-mesenchymal transition and cell cycle arrest.

Cancer cell international

Li L,Li P,Zhang W,Zhou H,Guo E,Hu G,Zhang L

Thu Feb 10 00:00:00 EST 2022

FERMT1 contributes to the migration and invasion of nasopharyngeal carcinoma through epithelial-mesenchymal transition and cell cycle arrest.

Cancer cell international

Li L,Li P,Zhang W,Zhou H,Guo E,Hu G,Zhang L

Thu Feb 10 00:00:00 EST 2022

Krüppel-like Factor 13 Promotes HCC Progression by Transcriptional Regulation of HMGCS1-mediated Cholesterol Synthesis.

Journal of clinical and translational hepatology

Chen CC,Xie XM,Zhao XK,Zuo S,Li HY

Wed Dec 28 00:00:00 EST 2022

PRIM2 Promotes Cell Cycle and Tumor Progression in p53-Mutant Lung Cancer.

Cancers

Wang T,Tang T,Jiang Y,He T,Qi L,Chang H,Qiao Y,Sun M,Shan C,Zhu X,Liu J,Wang J

Mon Jul 11 00:00:00 EDT 2022

High expression of eIF4A1 predicts unfavorable prognosis in clear cell renal cell carcinoma.

Molecular and cellular probes

Zhang LL,Chang W,He SB,Zhang B,Ma G,Shang PF,Yue ZJ

Sat Oct 01 00:00:00 EDT 2022

Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.

International journal of molecular sciences

Zhang Y,Ma P,Duan Z,Liu Y,Mi Y,Fan D

Fri Feb 11 00:00:00 EST 2022

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation.

Molecular cell

Orellana EA,Liu Q,Yankova E,Pirouz M,De Braekeleer E,Zhang W,Lim J,Aspris D,Sendinc E,Garyfallos DA,Gu M,Ali R,Gutierrez A,Mikutis S,Bernardes GJL,Fischer ES,Bradley A,Vassiliou GS,Slack FJ,Tzelepis K,Gregory RI

Thu Aug 19 00:00:00 EDT 2021

Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells.

The Journal of biological chemistry

Wang X,Wang X,Zhang X,Zhang Y,Zhu Z,Li Y,Zhang M,Ji J,Yu Y,Ye SD

Mon Nov 01 00:00:00 EDT 2021

SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease.

Frontiers in neurology

Li X,Liu T,Wu TT,Feng Y,Peng SJ,Yin H,Wu YC

Tue May 04 00:00:00 EDT 2021

Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell.

Environmental toxicology

Zhang B,Li X,Zhang X,Ye J,Zhao W,Zhang M,Xing J,Qi W,Ye L

Wed Sep 01 00:00:00 EDT 2021

Puromycin-sensitive aminopeptidase is required for C2C12 myoblast proliferation and differentiation.

Journal of cellular physiology

Osana S,Kitajima Y,Suzuki N,Nunomiya A,Takada H,Kubota T,Murayama K,Nagatomi R

Thu Jul 01 00:00:00 EDT 2021

CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.

Journal of cell communication and signaling

Yu S,Hu Q,Fan K,Yang C,Gao Y

Wed Sep 01 00:00:00 EDT 2021

MicroRNA-139 inhibits pancreatic-cancer carcinogenesis by suppressing RalB via the Ral/RAC/PI3K pathway.

Archives of biochemistry and biophysics

Wang Y,Zheng Y,Chen Q,Dai Y,Li T

Tue Jun 15 00:00:00 EDT 2021

Bioinformatics analysis combined with experiments predicts CENPK as a potential prognostic factor for lung adenocarcinoma.

Cancer cell international

Ma J,Chen X,Lin M,Wang Z,Wu Y,Li J

Thu Jan 21 00:00:00 EST 2021

Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.

Frontiers in oncology

Wang J,Li H,Wang L,Zhang J,Li M,Qiao L,Zhang J,Liu L,Zhang C,Gao J,Li W

Tue Sep 07 00:00:00 EDT 2021

Pan-Cancer Analyses Reveal Oncogenic Role and Prognostic Value of F-Box Only Protein 22.

Frontiers in oncology

Chen S,Ma S,Yan J,Wang H,Ding B,Guo Z,Ma Y,Chen X,Wang Y

Wed Feb 16 00:00:00 EST 2022

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.

Cell chemical biology

Li L,Chen N,Xia D,Xu S,Dai W,Tong Y,Wang L,Jiang Z,You Q,Xu X

Thu Oct 21 00:00:00 EDT 2021

Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT.

Journal of Cancer

Ye J,Qi L,Liang J,Zong K,Liu W,Li R,Feng R,Zhai W

Tue May 18 00:00:00 EDT 2021

Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.

Inflammation

Zeng L,Li A,Zhang Z,Zhang F,Chen H,Wang Y,Ding X,Luo H

Wed Dec 01 00:00:00 EST 2021

High expression of DLL3 is associated with a poor prognosis and immune infiltration in invasive breast cancer patients.

Translational oncology

Yuan C,Chang K,Xu C,Li Q,Du Z

Thu Jul 01 00:00:00 EDT 2021

CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression.

Frontiers in cell and developmental biology

Xu S,Lian Z,Zhang S,Xu Y,Zhang H

Tue Aug 17 00:00:00 EDT 2021

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.

Journal of experimental & clinical cancer research : CR

Xie C,Zhou X,Liang C,Li X,Ge M,Chen Y,Yin J,Zhu J,Zhong C

Tue Aug 24 00:00:00 EDT 2021

RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.

Experimental and molecular pathology

Fan H,Xin T,Dong X,Yang F,Zhang R,Feng S,He D,Guo H,Pang Q

Mon Feb 01 00:00:00 EST 2021

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth.

Frontiers in endocrinology

Jiang M,Kuang Z,He Y,Cao Y,Yu T,Cheng J,Liu W,Wang W

Thu Dec 16 00:00:00 EST 2021

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth.

Frontiers in endocrinology

Jiang M,Kuang Z,He Y,Cao Y,Yu T,Cheng J,Liu W,Wang W

Thu Dec 16 00:00:00 EST 2021

SNAPIN Regulates Cell Cycle Progression to Promote Pancreatic β Cell Growth.

Frontiers in endocrinology

Jiang M,Kuang Z,He Y,Cao Y,Yu T,Cheng J,Liu W,Wang W

Thu Dec 16 00:00:00 EST 2021

Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.

International journal of biological sciences

Bai M,Cui M,Li M,Yao X,Wu Y,Zheng L,Sun L,Song Q,Wang S,Liu L,Yu C,Huang Y

Tue Feb 22 00:00:00 EST 2022

SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.

Stem cell reviews and reports

Liao X,Wu C,Shao Z,Zhang S,Zou Y,Wang K,Ha Y,Xing J,Zheng A,Shen Z,Zheng S,Guo J,Jie W

Sun Aug 01 00:00:00 EDT 2021

HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6.

iScience

Yin M,Cheng M,Liu C,Wu K,Xiong W,Fang J,Li Y,Zhang B

Fri Nov 19 00:00:00 EST 2021

Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma.

Journal of cellular and molecular medicine

Cui XH,Peng QJ,Li RZ,Lyu XJ,Zhu CF,Qin XH

Wed Dec 01 00:00:00 EST 2021

Acyl-CoA Thioesterase 7 is Transcriptionally Activated by Krüppel-Like Factor 13 and Promotes the Progression of Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma

Xie X,Chen C,Feng S,Zuo S,Zhao X,Li H

Fri Apr 29 00:00:00 EDT 2022

GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia.

Cell death & disease

Zhou C,Du J,Zhao L,Liu W,Zhao T,Liang H,Fang P,Zhang K,Zeng H

Wed Mar 03 00:00:00 EST 2021

Deletion of p16 accelerates fracture healing in geriatric mice.

American journal of translational research

Ding Q,Liu H,Liu L,Ma C,Qin H,Wei Y,Ren Y

Thu Nov 18 00:00:00 EST 2021

Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression.

Cell death discovery

Zhou B,Ge Y,Shao Q,Yang L,Chen X,Jiang G

Sat Jun 26 00:00:00 EDT 2021

Inhibition of cyclooxygenase-2 enhanced intestinal epithelial homeostasis via suppressing β-catenin signalling pathway in experimental liver fibrosis.

Journal of cellular and molecular medicine

Zhang L,Tai Y,Zhao C,Ma X,Tang S,Tong H,Tang C,Gao J

Sun Aug 01 00:00:00 EDT 2021

LncRNA LINC00680 promotes lung adenocarcinoma growth via binding to GATA6 and canceling GATA6-mediated suppression of SOX12 expression.

Experimental cell research

Sun X,Wang R,Tan M,Tian X,Meng J

Sun Aug 01 00:00:00 EDT 2021

Apatinib regulates the growth of gastric cancer cells by modulating apoptosis and autophagy.

Naunyn-Schmiedeberg's archives of pharmacology

Liu X,Zheng Q,Yu Q,Hu Y,Cheng Y,Shao Z,Chen L,Ding W,Gao D

Sat May 01 00:00:00 EDT 2021

CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.

Frontiers in molecular biosciences

Feng F,Zhao Z,Zhou Y,Cheng Y,Wu X,Heng X

Tue Aug 24 00:00:00 EDT 2021

AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang Z,Wu H,Huang S,Chen L,Chen X,Zhang W,Liao L,Zhang X

Tue Jun 01 00:00:00 EDT 2021

TROAP regulates cell cycle and promotes tumor progression through Wnt/β-Catenin signaling pathway in glioma cells.

CNS neuroscience & therapeutics

Zhao ZQ,Wu XJ,Cheng YH,Zhou YF,Ma XM,Zhang J,Heng XY,Feng F

Wed Jun 02 00:00:00 EDT 2021

CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.

Molecular medicine reports

Fu H,Zhang Y,Chen Y,Chen J,Chen P

Fri Jan 01 00:00:00 EST 2021

miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.

BioMed research international

Li D,Zhang Y,Li Y,Wang X,Wang F,Du J,Zhang H,Shi H,Wang Y,Gao Y,Feng Y,Yan J,Xue Y,Yang Y,Zhang J

Wed Jan 19 00:00:00 EST 2022

Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.

Cancer science

Ni Y,Yang Z,Agbana YL,Bai H,Wang L,Yang L,Yi Z,Cheng J,Zhang Q,Kuang Y,Zhu Y

Fri Oct 01 00:00:00 EDT 2021

HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.

Cancer medicine

Sun W,Li S,Tang G,Sun S,Luo Y,Bai R,Han L,Jiang X,Gao Y,Huang Z,Zhang J,Gong Y,Xie C

Sun Aug 01 00:00:00 EDT 2021

The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC.

Molecular cancer

Wang X,Xing L,Yang R,Chen H,Wang M,Jiang R,Zhang L,Chen J

Fri Jun 11 00:00:00 EDT 2021

The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC.

Molecular cancer

Wang X,Xing L,Yang R,Chen H,Wang M,Jiang R,Zhang L,Chen J

Fri Jun 11 00:00:00 EDT 2021

High Expression of PIGC Predicts Unfavorable Survival in Hepatocellular Carcinoma.

Journal of hepatocellular carcinoma

Guo X,Tian S,Cao P,Xie Y,Dong W

Fri Apr 22 00:00:00 EDT 2022

Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.

Bioorganic & medicinal chemistry

Qin J,Sun X,Ma Y,Cheng Y,Ma Q,Jing W,Qu S,Liu L

Fri Dec 31 00:00:00 EST 2021

CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.

Oncogenesis

Liao Q,Ren Y,Yang Y,Zhu X,Zhi Y,Zhang Y,Chen Y,Ding Y,Zhao L

Fri Dec 03 00:00:00 EST 2021

LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.

Cell death & disease

Tao Y,Zhang J,Chen L,Liu X,Yao M,Zhang H

Tue May 18 00:00:00 EDT 2021

Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.

Bioorganic & medicinal chemistry

Qin J,Qu S,Zhu K,Cheng Y,Pan G,Jing W,Liu X,Sun X,Liu L

Mon Feb 15 00:00:00 EST 2021

ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells.

Molecular and cellular endocrinology

Ma L,Li C,Lian S,Xu B,Yuan J,Lu J,Yang H,Guo J,Ji H

Fri Jan 01 00:00:00 EST 2021

Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.

Molecular pharmaceutics

Li TF,Xu HZ,Xu YH,Yu TT,Tang JM,Li K,Wang C,Peng XC,Li QR,Sang XY,Zheng MY,Liu Y,Zhao L,Chen X

Mon Sep 06 00:00:00 EDT 2021

Activity Components from Gynostemma pentaphyllum for Preventing Hepatic Fibrosis and of Its Molecular Targets by Network Pharmacology Approach.

Molecules (Basel, Switzerland)

Zhang Y,Shi G,Luo Z,Wang J,Wu S,Zhang X,Zhao Y

Tue May 18 00:00:00 EDT 2021

NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer.

International journal of biological sciences

Bai R,Yuan C,Sun W,Zhang J,Luo Y,Gao Y,Li Y,Gong Y,Xie C

Fri Mar 25 00:00:00 EDT 2022

Identification and Validation of HOTAIRM1 as a Novel Biomarker for Oral Squamous Cell Carcinoma.

Frontiers in bioengineering and biotechnology

Yu Y,Niu J,Zhang X,Wang X,Song H,Liu Y,Jiao X,Chen F

Sat Jan 29 00:00:00 EST 2022

Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.

Cancer biology & medicine

Chen T,Liu L,Zou Y,Hu X,Zhang W,Zhou T,Luo X,Fu W,Xu J

Mon Feb 15 00:00:00 EST 2021

KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.

Cancer communications (London, England)

Wei H,Ma W,Lu X,Liu H,Lin K,Wang Y,Ye Z,Sun L,Huang Z,Pan T,Zhou Z,Cheng EY,Zhang H,Gao P,Zhong X

Wed Sep 01 00:00:00 EDT 2021

Long intergenic non-coding RNA 00473 promotes proliferation and migration of gastric cancer via the miR-16-5p/CCND2 axis and by regulating AQP3.

Cell death & disease

Zhuo S,Sun M,Bai R,Lu D,Di S,Ma T,Zou Z,Li H,Zhang Z

Sat May 15 00:00:00 EDT 2021

High PHD Finger Protein 19 (PHF19) expression predicts poor prognosis in colorectal cancer: a retrospective study.

PeerJ

Li P,Sun J,Ruan Y,Song L

Sun Apr 24 00:00:00 EDT 2022

eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.

Journal of translational medicine

Sun L,Liu S,Wang X,Zheng X,Chen Y,Shen H

Thu May 20 00:00:00 EDT 2021

(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells.

International journal of molecular sciences

Chen C,Wang YS,Zhang ET,Li GA,Liu WY,Li Y,Jin YH

Mon Dec 06 00:00:00 EST 2021

NEK7 promotes gastric cancer progression as a cell proliferation regulator.

Cancer cell international

Li YK,Zhu XR,Zhan Y,Yuan WZ,Jin WL

Sat Aug 21 00:00:00 EDT 2021

Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.

Frontiers in pharmacology

Yang M,Li WY,Xie J,Wang ZL,Wen YL,Zhao CC,Tao L,Li LF,Tian Y,Sheng J

Sat May 08 00:00:00 EDT 2021

Identification of miRNA in Sheep Intramuscular Fat and the Role of miR-193a-5p in Proliferation and Differentiation of 3T3-L1.

Frontiers in genetics

Han F,Zhou L,Zhao L,Wang L,Liu L,Li H,Qiu J,He J,Liu N

Tue May 04 00:00:00 EDT 2021

Rubioncolin C, a natural naphthohydroquinone dimer isolated from Rubia yunnanensis, inhibits the proliferation and metastasis by inducing ROS-mediated apoptotic and autophagic cell death in triple-negative breast cancer cells.

Journal of ethnopharmacology

Li L,Wang J,Feng L,Fan J,Wang J,Tan N,Wang Z

Wed Sep 15 00:00:00 EDT 2021

Dlx5 promotes cancer progression through regulation of CCND1 in oral squamous cell carcinoma (OSCC).

Biochemistry and cell biology = Biochimie et biologie cellulaire

Zhang J,Wu J,Chen Y,Zhang W

Sun Aug 01 00:00:00 EDT 2021

Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.

Oncology letters

Xing J,Li Y,Zhao H

Sat May 01 00:00:00 EDT 2021

Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes.

International journal of molecular medicine

Sun X,Fu P,Xie L,Chai S,Xu Q,Zeng L,Wang X,Jiang N,Sang M

Fri Jan 01 00:00:00 EST 2021

Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.

FEBS letters

Li S,Han J,Guo G,Sun Y,Zhang T,Zhao M,Xu Y,Cui Y,Liu Y,Zhang J

Sat Feb 01 00:00:00 EST 2020

lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer.

Molecular therapy. Nucleic acids

Na H,Li X,Zhang X,Xu Y,Sun Y,Cui J,Chen Z,Shi X,Ren S,Zuo Y

Fri Sep 04 00:00:00 EDT 2020

The lncRNA LINC01194/miR-486-5p Axis Facilitates Malignancy in Non-Small Cell Lung Cancer via Regulating CDK4.

OncoTargets and therapy

Xing Z,Zhang Z,Gao Y,Zhang X,Kong X,Zhang J,Bai H

Thu Apr 14 00:00:00 EDT 2022

Mitochondrial UQCC3 Modulates Hypoxia Adaptation by Orchestrating OXPHOS and Glycolysis in Hepatocellular Carcinoma.

Cell reports

Yang Y,Zhang G,Guo F,Li Q,Luo H,Shu Y,Shen Y,Gan J,Xu L,Yang H

Tue Nov 03 00:00:00 EST 2020

Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy.

Cell death & disease

Guan Y,Jiang S,Ye W,Ren X,Wang X,Zhang Y,Yin M,Wang K,Tao Y,Yang J,Cao D,Cheng Y

Tue Nov 03 00:00:00 EST 2020

Steroid receptor RNA activator inhibits the migration, invasion and stemness characteristics of renal cell carcinoma cells.

International journal of molecular medicine

Zhang C,Zhu N,Liu C,Wu H,Yin Y,Shi Y,Liao D,Qin L

Sun Nov 01 00:00:00 EDT 2020

Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.

Aging cell

Dang Y,An Y,He J,Huang B,Zhu J,Gao M,Zhang S,Wang X,Yang B,Xie Z

Wed Jan 01 00:00:00 EST 2020

Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.

JCI insight

Xia H,Li S,Li X,Wang W,Bian Y,Wei S,Grove S,Wang W,Vatan L,Liu JR,McLean K,Rattan R,Munkarah A,Guan JL,Kryczek I,Zou W

Thu Sep 17 00:00:00 EDT 2020

Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.

BioMed research international

Mao Y,Li W,Hua B,Gu X,Pan W,Chen Q,Xu B,Wang Z,Lu C

Thu Nov 19 00:00:00 EST 2020

UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.

Cell death & disease

Gu C,Zhao K,Zhou N,Liu F,Xie F,Yu S,Feng Y,Chen L,Yang J,Tian F,Jiang G

Thu Sep 10 00:00:00 EDT 2020

Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.

Biochemical pharmacology

Deng X,Zhao J,Qu L,Duan Z,Fu R,Zhu C,Fan D

Sat Aug 01 00:00:00 EDT 2020

METTL3/YTHDF2 m⁶ A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer.

Journal of cellular and molecular medicine

Xie H,Li J,Ying Y,Yan H,Jin K,Ma X,He L,Xu X,Liu B,Wang X,Zheng X,Xie L

Wed Apr 01 00:00:00 EDT 2020

Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.

Bioscience, biotechnology, and biochemistry

Zhang L,Wang Z,Kong D,Zhao X,Chen X,Chai W

Sat Aug 01 00:00:00 EDT 2020

RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.

Oncogene

Yu Y,Chen L,Zhao G,Li H,Guo Q,Zhu S,Li P,Min L,Zhang S

Sat Feb 01 00:00:00 EST 2020

Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met.

The Kaohsiung journal of medical sciences

Chen JJ,Sun X,Mao QQ,Jiang XY,Zhao XG,Xu WJ,Zhong L

Sun Mar 01 00:00:00 EST 2020

1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells.

The Journal of pharmacy and pharmacology

Wang L,Xu X,Liu T,Wang J,Shen J,Guo M,Wu Y,Zhai X,Zuo D

Thu Oct 01 00:00:00 EDT 2020

Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Liu A,Zuo Z,Liu L,Liu L

Thu Oct 01 00:00:00 EDT 2020

lncRNA RP11-624L4.1 Is Associated with Unfavorable Prognosis and Promotes Proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 Pathway in NPC.

Molecular therapy. Nucleic acids

Zhou L,Liu R,Liang X,Zhang S,Bi W,Yang M,He Y,Jin J,Li S,Yang X,Fu J,Zhang P

Fri Dec 04 00:00:00 EST 2020

lncRNA RP11-624L4.1 Is Associated with Unfavorable Prognosis and Promotes Proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 Pathway in NPC.

Molecular therapy. Nucleic acids

Zhou L,Liu R,Liang X,Zhang S,Bi W,Yang M,He Y,Jin J,Li S,Yang X,Fu J,Zhang P

Fri Dec 04 00:00:00 EST 2020

lncRNA RP11-624L4.1 Is Associated with Unfavorable Prognosis and Promotes Proliferation via the CDK4/6-Cyclin D1-Rb-E2F1 Pathway in NPC.

Molecular therapy. Nucleic acids

Zhou L,Liu R,Liang X,Zhang S,Bi W,Yang M,He Y,Jin J,Li S,Yang X,Fu J,Zhang P

Fri Dec 04 00:00:00 EST 2020

Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression.

Cell death & disease

Ji X,Shan L,Shen P,He M

Mon Jan 06 00:00:00 EST 2020

Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer.

Cancer letters

Yang Y,Wei Q,Tang Y,Luo Q,Zhao H,He M,Wang H,Zeng Q,Lu W,Xu J,Liu T,Yi P

Fri Apr 10 00:00:00 EDT 2020

siRNA knockdown of alanine aminopeptidase impairs myoblast proliferation and differentiation.

Experimental cell research

Osana S,Kitajima Y,Suzuki N,Xu Y,Murayama K,Nagatomi R

Tue Dec 01 00:00:00 EST 2020

CDC27 Promotes Tumor Progression and Affects PD-L1 Expression in T-Cell Lymphoblastic Lymphoma.

Frontiers in oncology

Song Y,Song W,Li Z,Song W,Wen Y,Li J,Xia Q,Zhang M

Mon Feb 15 00:00:00 EST 2021

TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.

OncoTargets and therapy

Zhang X,Luo Y,Li Q

Fri Apr 15 00:00:00 EDT 2022

MiR-23a-3p promoted G1/S cell cycle transition by targeting protocadherin17 in hepatocellular carcinoma.

Journal of physiology and biochemistry

Xiang Y,Yang Y,Lin C,Wu J,Zhang X

Sat Feb 01 00:00:00 EST 2020

Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.

Pharmaceutical biology

Gou W,Luo N,Wei H,Wu H,Yu X,Duan Y,Bi C,Ning H,Hou W,Li Y

Tue Dec 01 00:00:00 EST 2020

Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26.

Cell death & disease

Jin C,Li Y,Su Y,Guo Z,Wang X,Wang S,Zhang F,Zhang Z,Shao J,Zheng S

Sun Oct 11 00:00:00 EDT 2020

Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21^Cip1 and p27^Kip1.

Journal of cellular and molecular medicine

Zhang D,Fan R,Lei L,Lei L,Wang Y,Lv N,Chen P,Williamson RA,Wang B,Hu J

Sat Aug 01 00:00:00 EDT 2020

Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells.

Frontiers in oncology

Chen CY,Chen CC,Chuang WY,Leu YL,Ueng SH,Hsueh C,Yeh CT,Wang TH

Mon Sep 28 00:00:00 EDT 2020

Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.

Journal of food biochemistry

Peng F,Li G,Xie Y,Yin HY,Li XJ,Yang YD

Mon Jun 01 00:00:00 EDT 2020

Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.

Molecular carcinogenesis

Pan H,Liu F,Wang J,Zhao M,Wang D,Jia C,Wang T,Chen Z,Fan Y,Liang D,Meng Q

Mon Jun 01 00:00:00 EDT 2020

2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression.

Frontiers in oncology

Chen CY,Fang JY,Chen CC,Chuang WY,Leu YL,Ueng SH,Wei LS,Cheng SF,Hsueh C,Wang TH

Mon Sep 28 00:00:00 EDT 2020

2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression.

Frontiers in oncology

Chen CY,Fang JY,Chen CC,Chuang WY,Leu YL,Ueng SH,Wei LS,Cheng SF,Hsueh C,Wang TH

Mon Sep 28 00:00:00 EDT 2020

CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.

Cell proliferation

Ying Y,Li J,Xie H,Yan H,Jin K,He L,Ma X,Wu J,Xu X,Fang J,Wang X,Zheng X,Liu B,Xie L

Sat Feb 01 00:00:00 EST 2020

A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation.

Molecular therapy. Nucleic acids

Zhang Y,Mao X,Chen W,Guo X,Yu L,Jiang F,Wang X,Li W,Guo Q,Li T,Lin N

Fri Mar 06 00:00:00 EST 2020

A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation.

Molecular therapy. Nucleic acids

Zhang Y,Mao X,Chen W,Guo X,Yu L,Jiang F,Wang X,Li W,Guo Q,Li T,Lin N

Fri Mar 06 00:00:00 EST 2020

SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway.

Cell death & disease

Lei XX,Liu Y,Wang JX,Cai Q,Yan M,He HP,Liu Q,Long ZJ,Guan Z

Thu May 07 00:00:00 EDT 2020

Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21^Waf1 signalling pathway.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Du S,Wang H,Cai J,Ren R,Zhang W,Wei W,Shen X

Wed Apr 01 00:00:00 EDT 2020

Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21^Waf1 signalling pathway.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Du S,Wang H,Cai J,Ren R,Zhang W,Wei W,Shen X

Wed Apr 01 00:00:00 EDT 2020

The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.

Chemical & pharmaceutical bulletin

Feng B,Zhao C,Li J,Yu J,Zhang Y,Zhang X,Tian T,Zhao L

Fri Apr 30 00:00:00 EDT 2021

Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.

Oncology reports

Yan X,Yang C,Hu W,Chen T,Wang Q,Pan F,Qiu B,Tang B

Wed Jul 01 00:00:00 EDT 2020

Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.

Life sciences

Zhang Y,Liu X,Yu M,Xu M,Xiao Y,Ma W,Huang L,Li X,Ye X

Sun Nov 01 00:00:00 EDT 2020

A Novel lncRNA ENST00000512916 Facilitates Cell Proliferation, Migration and Cell Cycle Progression in Ameloblastoma.

OncoTargets and therapy

Sun Y,Niu X,Wang G,Qiao X,Chen L,Zhong M

Wed Apr 13 00:00:00 EDT 2022

Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.

Biochemical and biophysical research communications

Chen L,Wang X,Cheng H,Zhang W,Liu Y,Zeng W,Yu L,Huang C,Liu G

Thu Dec 17 00:00:00 EST 2020

Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.

Biochemical and biophysical research communications

Chen L,Wang X,Cheng H,Zhang W,Liu Y,Zeng W,Yu L,Huang C,Liu G

Thu Dec 17 00:00:00 EST 2020

Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.

Biochemical and biophysical research communications

Chen L,Wang X,Cheng H,Zhang W,Liu Y,Zeng W,Yu L,Huang C,Liu G

Thu Dec 17 00:00:00 EST 2020

A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.

Cancer management and research

Lv Z,Wu K,Qin X,Yuan J,Yan M,Zhang J,Wang L,Ji T,Cao W,Chen W

Fri Apr 15 00:00:00 EDT 2022

SHCBP1 Promotes Papillary Thyroid Carcinoma Carcinogenesis and Progression Through Promoting Formation of Integrin and Collagen and Maintaining Cell Stemness.

Frontiers in endocrinology

Geng H,Guo M,Xu W,Zang X,Wu T,Teng F,Wang Y,Liu X,Wang X,Sun Q,Liang J

Thu May 27 00:00:00 EDT 2021

S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1 Degradation to Regulate Hepatoblastoma Progression.

Molecular therapy oncolytics

He W,Zhang J,Liu B,Liu X,Liu G,Xie L,He J,Wei M,Li K,Ma J,Dong R,Ma D,Dong K,Ye M

Wed Dec 16 00:00:00 EST 2020

An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Dasgupta A,Chen KH,Wu D,Hoskin V,Mewburn J,Lima PDA,Parlow LRG,Hindmarch CCT,Martin A,Sykes EA,Tayade C,Lightbody ED,Madarnas Y,SenGupta SK,Elliott BE,Nicol CJB,Archer SL

Wed Apr 01 00:00:00 EDT 2020

MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3.

International journal of molecular medicine

Li H,Pan R,Lu Q,Ren C,Sun J,Wu H,Wen J,Chen H

Fri May 01 00:00:00 EDT 2020

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.

International journal of molecular sciences

Zhao Q,Zhu HP,Xie X,Mao Q,Liu YQ,He XH,Peng C,Jiang QL,Huang W

Sat Mar 07 00:00:00 EST 2020

MiR-181b-5p modulates chemosensitivity of glioma cells to temozolomide by targeting Bcl-2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang X,Yu J,Zhao C,Ren H,Yuan Z,Zhang B,Zhuang J,Wang J,Feng B

Tue Jan 01 00:00:00 EST 2019

MiR-181b-5p modulates chemosensitivity of glioma cells to temozolomide by targeting Bcl-2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang X,Yu J,Zhao C,Ren H,Yuan Z,Zhang B,Zhuang J,Wang J,Feng B

Tue Jan 01 00:00:00 EST 2019

MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.

Journal of cellular physiology

Zhao F,Zhou LH,Ge YZ,Ping WW,Wu X,Xu ZL,Wang M,Sha ZL,Jia RP

Mon Apr 01 00:00:00 EDT 2019

MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle.

Journal of cellular physiology

Zhao F,Zhou LH,Ge YZ,Ping WW,Wu X,Xu ZL,Wang M,Sha ZL,Jia RP

Mon Apr 01 00:00:00 EDT 2019

Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.

Medical science monitor : international medical journal of experimental and clinical research

Li Y,Zu X,Hu X,Wang L,He W

Mon Nov 25 00:00:00 EST 2019

Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling.

BMC veterinary research

Diao H,Cheng N,Zhao Y,Xu H,Dong H,Thamm DH,Zhang D,Lin D

Fri Aug 02 00:00:00 EDT 2019

CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.

Stem cells international

Rui YF,Chen MH,Li YJ,Xiao LF,Geng P,Wang P,Xu ZY,Zhang XP,Dai GC

Thu Oct 01 00:00:00 EDT 2020

Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway.

Cancer medicine

Wang S,Hu H,Zhong B,Shi D,Qing X,Cheng C,Deng X,Zhang Z,Shao Z

Sun Dec 01 00:00:00 EST 2019

Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM.

Breast cancer (Tokyo, Japan)

Cheng X,Tan S,Duan F,Yuan Q,Li Q,Deng G

Fri Nov 01 00:00:00 EDT 2019

[6]-Gingerol enhances the cisplatin sensitivity of gastric cancer cells through inhibition of proliferation and invasion via PI3K/AKT signaling pathway.

Phytotherapy research : PTR

Luo Y,Zha L,Luo L,Chen X,Zhang Q,Gao C,Zhuang X,Yuan S,Qiao T

Wed May 01 00:00:00 EDT 2019

Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway.

American journal of translational research

Liu H,Feng XD,Yang B,Tong RL,Lu YJ,Chen DY,Zhou L,Xie HY,Zheng SS,Wu J

Thu Oct 01 00:00:00 EDT 2020

Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.

Toxicology and applied pharmacology

Yu Z,Jv Y,Cai L,Tian X,Huo X,Wang C,Zhang B,Sun C,Ning J,Feng L,Zhang H,Ma X

Wed May 15 00:00:00 EDT 2019

Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Feng F,Wang Z,Li R,Wu Q,Gu C,Xu Y,Peng W,Han D,Zhou X,Wu J,He H

Mon Apr 01 00:00:00 EDT 2019

Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.

Journal of enzyme inhibition and medicinal chemistry

Qin F,Wang Y,Jiang X,Wang Y,Zhang N,Wen X,Wang L,Jiang Q,He G

Sun Dec 01 00:00:00 EST 2019

Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.

BMC complementary and alternative medicine

Que Z,Zhou Z,Luo B,Dong C,Jiang Y,Li H,Tian J

Wed Aug 07 00:00:00 EDT 2019

Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.

Oncology reports

Zhang X,Yang X,Zhu S,Li Q,Zou N

Fri Mar 01 00:00:00 EST 2019

Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.

Molecular cancer

Chen J,Yu Y,Li H,Hu Q,Chen X,He Y,Xue C,Ren F,Ren Z,Li J,Liu L,Duan Z,Cui G,Sun R

Sat Mar 02 00:00:00 EST 2019

Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway.

Experimental eye research

Zheng M,Tian C,Fan T,Xu B

Thu Aug 01 00:00:00 EDT 2019

Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma.

Cell death & disease

Huang L,Wang Y,Chen J,Wang Y,Zhao Y,Wang Y,Ma Y,Chen X,Liu W,Li Z,Zhao L,Shan B,Dong X,Li D,Shao S,Song Y,Zhan Q,Liu X

Thu Jul 04 00:00:00 EDT 2019

Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.

Nature communications

Su D,Zhang D,Jin J,Ying L,Han M,Chen K,Li B,Wu J,Xie Z,Zhang F,Lin Y,Cheng G,Li JY,Huang M,Wang J,Wang K,Zhang J,Li F,Xiong L,Futreal A,Mao W

Thu Nov 07 00:00:00 EST 2019

RING finger protein 10 is a potential drug target for diabetic vascular complications.

Molecular medicine reports

Li S,Yu G,Huang W,Wang R,Pu P,Chen M

Thu Aug 01 00:00:00 EDT 2019

LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma.

European review for medical and pharmacological sciences

Luo XF,Wu XJ,Wei X,Wang AG,Wang SH,Wang JL

Tue Oct 01 00:00:00 EDT 2019

Shp2 in myocytes is essential for cardiovascular and neointima development.

Journal of molecular and cellular cardiology

Gong H,Ni J,Xu Z,Huang J,Zhang J,Huang Y,Zeng C,Zhang X,Cheng H,Ke Y

Sun Dec 01 00:00:00 EST 2019

Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).

Cancer cell international

Zhang C,Wang B,Wang X,Sheng X,Cui Y

Tue Apr 12 00:00:00 EDT 2022

CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.

Cancer letters

Zheng F,Wang M,Li Y,Huang C,Tao D,Xie F,Zhang H,Sun J,Zhang C,Gu C,Wang Z,Jiang G

Sat Sep 28 00:00:00 EDT 2019

CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.

Nature communications

Sang Y,Li Y,Zhang Y,Alvarez AA,Yu B,Zhang W,Hu B,Cheng SY,Feng H

Thu Sep 05 00:00:00 EDT 2019

Ginsenoside Re inhibits PDGF-BB-induced VSMC proliferation via the eNOS/NO/cGMP pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gao Y,Zhu P,Xu SF,Li YQ,Deng J,Yang DL

Mon Jul 01 00:00:00 EDT 2019

P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.

International journal of biological sciences

Li T,Wang F,Dang Y,Dong J,Zhang Y,Zhang C,Liu P,Gao Y,Wang X,Yang S,Lu S

Mon Apr 27 00:00:00 EDT 2020

P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.

International journal of biological sciences

Li T,Wang F,Dang Y,Dong J,Zhang Y,Zhang C,Liu P,Gao Y,Wang X,Yang S,Lu S

Mon Apr 27 00:00:00 EDT 2020

Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.

Journal of Cancer

Tang G,Zeng Z,Sun W,Li S,You C,Tang F,Peng S,Ma S,Luo Y,Xu J,Tian X,Zhang N,Gong Y,Xie C

Thu Oct 01 00:00:00 EDT 2020

The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.

PloS one

Liu H,Zhao J,Fu R,Zhu C,Fan D

Fri Jan 24 00:00:00 EST 2020

A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.

Toxicology and applied pharmacology

Shen J,Wang J,Du J,Wang L,Zhou X,Chang X,Li Z,Zhai X,Zuo D,Wu Y

Fri Nov 15 00:00:00 EST 2019

HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition.

BioMed research international

Chen Y,Huang F,Deng L,Yuan X,Tao Q,Wang T,Li D,Fan Y,Peng Q,Tang D

Thu Apr 23 00:00:00 EDT 2020

Downregulation of CDKL1 suppresses neuroblastoma cell proliferation, migration and invasion.

Cellular & molecular biology letters

Li W,Cao J,Liu J,Chu W,Zhang C,Chen S,Kang Z

Mon Apr 15 00:00:00 EDT 2019

The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines.

OncoTargets and therapy

Wei Y,Liu P,Li Q,Du J,Chen Y,Wang Y,Shi H,Wang Y,Zhang H,Xue W,Gao Y,Li D,Feng Y,Yan J,Han J,Zhang J

Sun Apr 10 00:00:00 EDT 2022

LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04.

Journal of ophthalmology

Wang Y,Chen L,Gu Y,Wang Y,Yuan Y,Zhu Q,Bi M,Gu S

Wed Sep 30 00:00:00 EDT 2020

Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle.

International journal of oncology

Han Y,Liu C,Zhang D,Men H,Huo L,Geng Q,Wang S,Gao Y,Zhang W,Zhang Y,Jia Z

Sun Sep 01 00:00:00 EDT 2019

miR-30b suppresses the progression of breast cancer through inhibition of the PI3K/Akt signaling pathway by targeting Derlin-1.

Translational cancer research

Zhou J,Xiang AZ,Guo JF,Cui HD

Fri Feb 01 00:00:00 EST 2019

Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.

Cancer medicine

Li X,Fu Y,Xia X,Zhang X,Xiao K,Zhuang X,Zhang Y

Sun Sep 01 00:00:00 EDT 2019

Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.

Life sciences

Dong S,Ji J,Hu L,Wang H

Sat Jun 15 00:00:00 EDT 2019

Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.

BMC cancer

Shen Z,Liao X,Shao Z,Feng M,Yuan J,Wang S,Gan S,Ha Y,He Z,Jie W

Fri Mar 22 00:00:00 EDT 2019

MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer.

Aging

Wei C,Zhang R,Cai Q,Gao X,Tong F,Dong J,Hu Y,Wu G,Dong X

Sun Sep 08 00:00:00 EDT 2019

IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation.

Journal of experimental & clinical cancer research : CR

Zhang W,Lu Y,Li X,Zhang J,Lin W,Zhang W,Zheng L,Li X

Tue Jul 09 00:00:00 EDT 2019

Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma.

Journal of Cancer

Liu J,Min L,Zhu S,Guo Q,Li H,Zhang Z,Zhao Y,Xu C,Zhang S

Tue Sep 29 00:00:00 EDT 2020

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 EDT 2018

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 EDT 2018

Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.

Journal of pineal research

Yu Z,Tian X,Peng Y,Sun Z,Wang C,Tang N,Li B,Jian Y,Wang W,Huo X,Ma X

Wed Aug 01 00:00:00 EDT 2018

Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.

Journal of pineal research

Yu Z,Tian X,Peng Y,Sun Z,Wang C,Tang N,Li B,Jian Y,Wang W,Huo X,Ma X

Wed Aug 01 00:00:00 EDT 2018

MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.

Biological research

Wu T,Lin Y,Xie Z

Thu May 24 00:00:00 EDT 2018

MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.

Biological research

Wu T,Lin Y,Xie Z

Thu May 24 00:00:00 EDT 2018

Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.

Biological research

Meng M,Chen Y,Jia J,Li L,Yang S

Fri Aug 10 00:00:00 EDT 2018

Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.

Biological research

Meng M,Chen Y,Jia J,Li L,Yang S

Fri Aug 10 00:00:00 EDT 2018

8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.

Life sciences

Xiao Y,Tian C,Huang T,Han B,Wang M,Ma H,Li Z,Ye X,Li X

Mon Jan 01 00:00:00 EST 2018

8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.

Life sciences

Xiao Y,Tian C,Huang T,Han B,Wang M,Ma H,Li Z,Ye X,Li X

Mon Jan 01 00:00:00 EST 2018

Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.

Molecular pharmaceutics

Chen X,Liu C,Zhao R,Zhao P,Wu J,Zhou N,Ying M

Mon Nov 05 00:00:00 EST 2018

Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.

Molecular pharmaceutics

Chen X,Liu C,Zhao R,Zhao P,Wu J,Zhou N,Ying M

Mon Nov 05 00:00:00 EST 2018

LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.

Journal of cellular and molecular medicine

Liu Y,Wang LL,Chen S,Zong ZH,Guan X,Zhao Y

Wed Aug 01 00:00:00 EDT 2018

LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.

Journal of cellular and molecular medicine

Liu Y,Wang LL,Chen S,Zong ZH,Guan X,Zhao Y

Wed Aug 01 00:00:00 EDT 2018

LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.

Journal of cellular and molecular medicine

Liu Y,Wang LL,Chen S,Zong ZH,Guan X,Zhao Y

Wed Aug 01 00:00:00 EDT 2018

NF-κB and JNK mediated apoptosis and G₀/G₁ arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis.

Journal of ethnopharmacology

Zeng GZ,Wang Z,Zhao LM,Fan JT,Tan NH

Thu Jun 28 00:00:00 EDT 2018

NF-κB and JNK mediated apoptosis and G₀/G₁ arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis.

Journal of ethnopharmacology

Zeng GZ,Wang Z,Zhao LM,Fan JT,Tan NH

Thu Jun 28 00:00:00 EDT 2018

Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a.

Cancer biology & therapy

Hou P,Kang Y,Luo J

Thu Oct 01 00:00:00 EDT 2020

Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a.

Cancer biology & therapy

Hou P,Kang Y,Luo J

Thu Oct 01 00:00:00 EDT 2020

TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway.

Cell biology international

Li L,Qi Y,Ma X,Xiong G,Wang L,Bao C

Sat Sep 01 00:00:00 EDT 2018

TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway.

Cell biology international

Li L,Qi Y,Ma X,Xiong G,Wang L,Bao C

Sat Sep 01 00:00:00 EDT 2018

Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.

Oncology reports

Yun DP,Wang YQ,Meng DL,Ji YY,Chen JX,Chen HY,Lu DR

Thu Mar 01 00:00:00 EST 2018

Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.

Oncology reports

Yun DP,Wang YQ,Meng DL,Ji YY,Chen JX,Chen HY,Lu DR

Thu Mar 01 00:00:00 EST 2018

Anticancer effects of plant derived Anacardic acid on human breast cancer MDA-MB-231 cells.

American journal of translational research

Zhao Q,Zhang X,Cai H,Zhang P,Kong D,Ge X,Du M,Liang R,Dong W

Wed Sep 30 00:00:00 EDT 2020

Anticancer effects of plant derived Anacardic acid on human breast cancer MDA-MB-231 cells.

American journal of translational research

Zhao Q,Zhang X,Cai H,Zhang P,Kong D,Ge X,Du M,Liang R,Dong W

Wed Sep 30 00:00:00 EDT 2020

Overexpression of SMARCA2 or CAMK2D is associated with cisplatin resistance in human epithelial ovarian cancer.

Oncology letters

Xu X,Zheng Z,Jia L,Suo S,Liu B,Shao T,Tu Q,Hua Y,Xu H

Sat Sep 01 00:00:00 EDT 2018

Overexpression of SMARCA2 or CAMK2D is associated with cisplatin resistance in human epithelial ovarian cancer.

Oncology letters

Xu X,Zheng Z,Jia L,Suo S,Liu B,Shao T,Tu Q,Hua Y,Xu H

Sat Sep 01 00:00:00 EDT 2018

Jinfukang induces cellular apoptosis through activation of Fas and DR4 in A549 cells.

Oncology letters

Lu J,Chen J,Kang Y,Wu J,Shi H,Fu Y,Jiao L,Dong C,Li X,Jin Y,Zhao W,Xu L,Zhao X

Mon Oct 01 00:00:00 EDT 2018

Jinfukang induces cellular apoptosis through activation of Fas and DR4 in A549 cells.

Oncology letters

Lu J,Chen J,Kang Y,Wu J,Shi H,Fu Y,Jiao L,Dong C,Li X,Jin Y,Zhao W,Xu L,Zhao X

Mon Oct 01 00:00:00 EDT 2018

NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.

Cell death & disease

Lin C,Zhang J,Lu Y,Li X,Zhang W,Zhang W,Lin W,Zheng L,Li X

Thu Feb 15 00:00:00 EST 2018

NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.

Cell death & disease

Lin C,Zhang J,Lu Y,Li X,Zhang W,Zhang W,Lin W,Zheng L,Li X

Thu Feb 15 00:00:00 EST 2018

Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4.

Cell death & disease

Lin Z,Zhou Z,Guo H,He Y,Pang X,Zhang X,Liu Y,Ao X,Li P,Wang J

Tue May 22 00:00:00 EDT 2018

Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4.

Cell death & disease

Lin Z,Zhou Z,Guo H,He Y,Pang X,Zhang X,Liu Y,Ao X,Li P,Wang J

Tue May 22 00:00:00 EDT 2018

Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4.

Cell death & disease

Lin Z,Zhou Z,Guo H,He Y,Pang X,Zhang X,Liu Y,Ao X,Li P,Wang J

Tue May 22 00:00:00 EDT 2018

Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4.

Cell death & disease

Lin Z,Zhou Z,Guo H,He Y,Pang X,Zhang X,Liu Y,Ao X,Li P,Wang J

Tue May 22 00:00:00 EDT 2018

Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Men L,Sun J,Ren D

Fri Jan 25 00:00:00 EST 2019

Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Men L,Sun J,Ren D

Fri Jan 25 00:00:00 EST 2019

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.

BMC cancer

Liu W,Fan Y,Shi Y,Lin Z,Huang X,Huang W,Shen D,Qi Z

Wed Aug 29 00:00:00 EDT 2018

Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells.

BMC cancer

Liu W,Fan Y,Shi Y,Lin Z,Huang X,Huang W,Shen D,Qi Z

Wed Aug 29 00:00:00 EDT 2018

Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.

Molecules (Basel, Switzerland)

Wang W,Chen T,Xu H,Ren B,Cheng X,Qi R,Liu H,Wang Y,Yan L,Chen S,Yang Q,Chen C

Fri Jun 29 00:00:00 EDT 2018

SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway.

Cancer cell international

Hu R,Wang MQ,Niu WB,Wang YJ,Liu YY,Liu LY,Wang M,Zhong J,You HY,Wu XH,Deng N,Lu L,Wei LB

Wed Mar 30 00:00:00 EDT 2022

SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway.

Cancer cell international

Hu R,Wang MQ,Niu WB,Wang YJ,Liu YY,Liu LY,Wang M,Zhong J,You HY,Wu XH,Deng N,Lu L,Wei LB

Wed Mar 30 00:00:00 EDT 2022

SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway.

Cancer cell international

Hu R,Wang MQ,Niu WB,Wang YJ,Liu YY,Liu LY,Wang M,Zhong J,You HY,Wu XH,Deng N,Lu L,Wei LB

Wed Mar 30 00:00:00 EDT 2022

SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway.

Cancer cell international

Hu R,Wang MQ,Niu WB,Wang YJ,Liu YY,Liu LY,Wang M,Zhong J,You HY,Wu XH,Deng N,Lu L,Wei LB

Wed Mar 30 00:00:00 EDT 2022

Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.

Molecular cancer

Xie F,Li Y,Wang M,Huang C,Tao D,Zheng F,Zhang H,Zeng F,Xiao X,Jiang G

Wed Oct 03 00:00:00 EDT 2018

Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.

Molecular cancer

Xie F,Li Y,Wang M,Huang C,Tao D,Zheng F,Zhang H,Zeng F,Xiao X,Jiang G

Wed Oct 03 00:00:00 EDT 2018

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Hepatology communications

Takahashi S,Tanaka N,Fukami T,Xie C,Yagai T,Kim D,Velenosi TJ,Yan T,Krausz KW,Levi M,Gonzalez FJ

Sat Dec 01 00:00:00 EST 2018

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.

Hepatology communications

Takahashi S,Tanaka N,Fukami T,Xie C,Yagai T,Kim D,Velenosi TJ,Yan T,Krausz KW,Levi M,Gonzalez FJ

Sat Dec 01 00:00:00 EST 2018

Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.

Molecular medicine reports

Zhao X,Guo X,Shen J,Hua D

Mon Oct 01 00:00:00 EDT 2018

Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer.

Cell proliferation

Hu W,Wei H,Li K,Li P,Lin J,Feng R

Tue Aug 01 00:00:00 EDT 2017

Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer.

Cell proliferation

Hu W,Wei H,Li K,Li P,Lin J,Feng R

Tue Aug 01 00:00:00 EDT 2017

Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.

International journal of oncology

Chen M,Lv JM,Ye JQ,Cui XG,Qu FJ,Chen L,Liu X,Pan XW,Li L,Huang H,Yang QW,Chen J,Wang LH,Gao Y,Xu DF

Sat Jul 01 00:00:00 EDT 2017

Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells.

International journal of oncology

Chen M,Lv JM,Ye JQ,Cui XG,Qu FJ,Chen L,Liu X,Pan XW,Li L,Huang H,Yang QW,Chen J,Wang LH,Gao Y,Xu DF

Sat Jul 01 00:00:00 EDT 2017

CDKL1 promotes tumor proliferation and invasion in colorectal cancer.

OncoTargets and therapy

Qin C,Ren L,Ji M,Lv S,Wei Y,Zhu D,Lin Q,Xu P,Chang W,Xu J

Wed Nov 09 00:00:00 EST 2022

CDKL1 promotes tumor proliferation and invasion in colorectal cancer.

OncoTargets and therapy

Qin C,Ren L,Ji M,Lv S,Wei Y,Zhu D,Lin Q,Xu P,Chang W,Xu J

Wed Nov 09 00:00:00 EST 2022

The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.

Toxicology letters

Yang J,Qiao L,Zeng Z,Wang J,Zhu T,Wei J,Wu M,Ye S,Huang X,Ma D,Liu R,Gao Q

Wed Jan 04 00:00:00 EST 2017

The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.

Toxicology letters

Yang J,Qiao L,Zeng Z,Wang J,Zhu T,Wei J,Wu M,Ye S,Huang X,Ma D,Liu R,Gao Q

Wed Jan 04 00:00:00 EST 2017

Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4.

Gene

Chen S,Guan X,Wang LL,Li B,Sang XB,Liu Y,Zhao Y

Thu Nov 30 00:00:00 EST 2017

Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4.

Gene

Chen S,Guan X,Wang LL,Li B,Sang XB,Liu Y,Zhao Y

Thu Nov 30 00:00:00 EST 2017

Effects of high-intensity focused ultrasound on cisplatin-resistant human lung adenocarcinoma in vitro and in vivo.

Acta biochimica et biophysica Sinica

Zhang T,Chen L,Zhang S,Xu Y,Fan Y,Zhang L

Fri Dec 01 00:00:00 EST 2017

Effects of high-intensity focused ultrasound on cisplatin-resistant human lung adenocarcinoma in vitro and in vivo.

Acta biochimica et biophysica Sinica

Zhang T,Chen L,Zhang S,Xu Y,Fan Y,Zhang L

Fri Dec 01 00:00:00 EST 2017

High expression of ubiquitin-specific peptidase 39 is associated with the development of vascular remodeling.

Molecular medicine reports

He S,Zhong W,Yin L,Wang Y,Qiu Z,Song G

Mon May 01 00:00:00 EDT 2017

High expression of ubiquitin-specific peptidase 39 is associated with the development of vascular remodeling.

Molecular medicine reports

He S,Zhong W,Yin L,Wang Y,Qiu Z,Song G

Mon May 01 00:00:00 EDT 2017

Therapy Effects of Wogonin on Ovarian Cancer Cells.

BioMed research international

Ruibin J,Bo J,Danying W,Chihong Z,Jianguo F,Linhui G

Fri Jan 26 00:00:00 EST 2018

Therapy Effects of Wogonin on Ovarian Cancer Cells.

BioMed research international

Ruibin J,Bo J,Danying W,Chihong Z,Jianguo F,Linhui G

Fri Jan 26 00:00:00 EST 2018

Targeting cleavage and polyadenylation specific factor 1 via shRNA inhibits cell proliferation in human ovarian cancer.

Journal of biosciences

Zhang B,Liu Y,Liu D,Yang L

Fri Sep 01 00:00:00 EDT 2017

Targeting cleavage and polyadenylation specific factor 1 via shRNA inhibits cell proliferation in human ovarian cancer.

Journal of biosciences

Zhang B,Liu Y,Liu D,Yang L

Fri Sep 01 00:00:00 EDT 2017

Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.

Anti-cancer drugs

Chong D,Ma L,Liu F,Zhang Z,Zhao S,Huo Q,Zhang P,Zheng H,Liu H

Fri Sep 01 00:00:00 EDT 2017

Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.

Anti-cancer drugs

Chong D,Ma L,Liu F,Zhang Z,Zhao S,Huo Q,Zhang P,Zheng H,Liu H

Fri Sep 01 00:00:00 EDT 2017

Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.

Scientific reports

Huang T,Xiao Y,Yi L,Li L,Wang M,Tian C,Ma H,He K,Wang Y,Han B,Ye X,Li X

Mon Feb 06 00:00:00 EST 2017

Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.

Scientific reports

Huang T,Xiao Y,Yi L,Li L,Wang M,Tian C,Ma H,He K,Wang Y,Han B,Ye X,Li X

Mon Feb 06 00:00:00 EST 2017

Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells.

BMC complementary and alternative medicine

Pan J,Xu Y,Song H,Zhou X,Yao Z,Ji G

Tue Nov 28 00:00:00 EST 2017

Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/β-catenin signaling in colorectal cancer cells.

BMC complementary and alternative medicine

Pan J,Xu Y,Song H,Zhou X,Yao Z,Ji G

Tue Nov 28 00:00:00 EST 2017

Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer.

Medical oncology (Northwood, London, England)

Zeng T,Zhu L,Liao M,Zhuo W,Yang S,Wu W,Wang D

Wed Feb 01 00:00:00 EST 2017

Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.

Medical science monitor : international medical journal of experimental and clinical research

Zhou H,Zheng L,Lu K,Gao Y,Guo L,Xu W,Wang X

Sat Oct 07 00:00:00 EDT 2017

Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines.

Medical science monitor : international medical journal of experimental and clinical research

Zhou H,Zheng L,Lu K,Gao Y,Guo L,Xu W,Wang X

Sat Oct 07 00:00:00 EDT 2017

ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma.

Cancer letters

Xu S,Wang H,Pan H,Shi Y,Li T,Ge S,Jia R,Zhang H,Fan X

Mon Oct 10 00:00:00 EDT 2016

ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma.

Cancer letters

Xu S,Wang H,Pan H,Shi Y,Li T,Ge S,Jia R,Zhang H,Fan X

Mon Oct 10 00:00:00 EDT 2016

LSD1 is Required for Hair Cell Regeneration in Zebrafish.

Molecular neurobiology

He Y,Tang D,Cai C,Chai R,Li H

Sun May 01 00:00:00 EDT 2016

LSD1 is Required for Hair Cell Regeneration in Zebrafish.

Molecular neurobiology

He Y,Tang D,Cai C,Chai R,Li H

Sun May 01 00:00:00 EDT 2016

The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.

Cell biology international

Yin J,Sheng B,Han B,Pu A,Yang K,Li P,Wang Q,Xiao W,Yang H

Sun May 01 00:00:00 EDT 2016

The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.

Cell biology international

Yin J,Sheng B,Han B,Pu A,Yang K,Li P,Wang Q,Xiao W,Yang H

Sun May 01 00:00:00 EDT 2016

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.

Oncology reports

Wang J,Wan X,Gao Y,Zhong M,Sha L,Liu B,Zhang W,Tian L,Ruan W,Cao S,Huang M

Fri Jul 01 00:00:00 EDT 2016

Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.

Oncology reports

Wang J,Wan X,Gao Y,Zhong M,Sha L,Liu B,Zhang W,Tian L,Ruan W,Cao S,Huang M

Fri Jul 01 00:00:00 EDT 2016

Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.

Biotechnology and applied biochemistry

Li H,Zhou F,Du W,Dou J,Xu Y,Gao W,Chen G,Zuo X,Sun L,Zhang X,Yang S

Sun May 01 00:00:00 EDT 2016

Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.

Biotechnology and applied biochemistry

Li H,Zhou F,Du W,Dou J,Xu Y,Gao W,Chen G,Zuo X,Sun L,Zhang X,Yang S

Sun May 01 00:00:00 EDT 2016

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21^Waf1/Cip1 and p27^Kip1.

Taiwanese journal of obstetrics & gynecology

Zhou Y,Wang K,Zhen S,Wang R,Luo W

Thu Dec 01 00:00:00 EST 2016

Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21^Waf1/Cip1 and p27^Kip1.

Taiwanese journal of obstetrics & gynecology

Zhou Y,Wang K,Zhen S,Wang R,Luo W

Thu Dec 01 00:00:00 EST 2016

miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.

Cell death & disease

Wang X,Liang Z,Xu X,Li J,Zhu Y,Meng S,Li S,Wang S,Xie B,Ji A,Liu B,Zheng X,Xie L

Thu Dec 01 00:00:00 EST 2016

miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.

Cell death & disease

Wang X,Liang Z,Xu X,Li J,Zhu Y,Meng S,Li S,Wang S,Xie B,Ji A,Liu B,Zheng X,Xie L

Thu Dec 01 00:00:00 EST 2016

miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.

Oncotarget

Feng T,Shao F,Wu Q,Zhang X,Xu D,Qian K,Xie Y,Wang S,Xu N,Wang Y,Qi C

Tue Mar 29 00:00:00 EDT 2016

miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.

Oncotarget

Feng T,Shao F,Wu Q,Zhang X,Xu D,Qian K,Xie Y,Wang S,Xu N,Wang Y,Qi C

Tue Mar 29 00:00:00 EDT 2016

Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.

Journal of clinical biochemistry and nutrition

Fei Z,Gao Y,Qiu M,Qi X,Dai Y,Wang S,Quan Z,Liu Y,Ou J

Tue Mar 01 00:00:00 EST 2016

Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zhao Y,Zhang B,Lei Y,Sun J,Zhang Y,Yang S,Zhang X

Sat Oct 01 00:00:00 EDT 2016

Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Zhao Y,Zhang B,Lei Y,Sun J,Zhang Y,Yang S,Zhang X

Sat Oct 01 00:00:00 EDT 2016

Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance.

Scientific reports

Zhao Y,Huan ML,Liu M,Cheng Y,Sun Y,Cui H,Liu DZ,Mei QB,Zhou SY

Wed Oct 12 00:00:00 EDT 2016

Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance.

Scientific reports

Zhao Y,Huan ML,Liu M,Cheng Y,Sun Y,Cui H,Liu DZ,Mei QB,Zhou SY

Wed Oct 12 00:00:00 EDT 2016

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.

Journal of experimental & clinical cancer research : CR

Zhang Z,Li HM,Zhou C,Li Q,Ma L,Zhang Z,Sun Y,Wang L,Zhang X,Zhu B,Hong YS,Wu CZ,Liu H

Thu Sep 22 00:00:00 EDT 2016

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.

Journal of experimental & clinical cancer research : CR

Zhang Z,Li HM,Zhou C,Li Q,Ma L,Zhang Z,Sun Y,Wang L,Zhang X,Zhu B,Hong YS,Wu CZ,Liu H

Thu Sep 22 00:00:00 EDT 2016

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.

Scientific reports

Zheng ZG,Xu H,Suo SS,Xu XL,Ni MW,Gu LH,Chen W,Wang LY,Zhao Y,Tian B,Hua YJ

Thu May 19 00:00:00 EDT 2016

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.

Scientific reports

Zheng ZG,Xu H,Suo SS,Xu XL,Ni MW,Gu LH,Chen W,Wang LY,Zhao Y,Tian B,Hua YJ

Thu May 19 00:00:00 EDT 2016

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.

Nutrients

Wang Y,Zhang XN,Xie WH,Zheng YX,Cao JP,Cao PR,Chen QJ,Li X,Sun CD

Tue Sep 27 00:00:00 EDT 2016

The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.

Nutrients

Wang Y,Zhang XN,Xie WH,Zheng YX,Cao JP,Cao PR,Chen QJ,Li X,Sun CD

Tue Sep 27 00:00:00 EDT 2016

Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.

International journal of oncology

Xiao W,Jiang Y,Men Q,Yuan L,Huang Z,Liu T,Li W,Liu X

Thu Jan 01 00:00:00 EST 2015

Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.

International journal of oncology

Xiao W,Jiang Y,Men Q,Yuan L,Huang Z,Liu T,Li W,Liu X

Thu Jan 01 00:00:00 EST 2015

miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.

International journal of oncology

He K,Tong D,Zhang S,Cai D,Wang L,Yang Y,Gao L,Chang S,Guo B,Song T,Li A,Huang C

Thu Oct 01 00:00:00 EDT 2015

miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.

International journal of oncology

He K,Tong D,Zhang S,Cai D,Wang L,Yang Y,Gao L,Chang S,Guo B,Song T,Li A,Huang C

Thu Oct 01 00:00:00 EDT 2015

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Chemical research in toxicology

Song X,Li L,Shi Q,Lehmler HJ,Fu J,Su C,Xia X,Song E,Song Y

Mon Nov 16 00:00:00 EST 2015

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Chemical research in toxicology

Song X,Li L,Shi Q,Lehmler HJ,Fu J,Su C,Xia X,Song E,Song Y

Mon Nov 16 00:00:00 EST 2015

High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma.

Oncotarget

Meng D,Chen Y,Yun D,Zhao Y,Wang J,Xu T,Li X,Wang Y,Yuan L,Sun R,Song X,Huai C,Hu L,Yang S,Min T,Chen J,Chen H,Lu D

Tue Mar 10 00:00:00 EDT 2015

High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma.

Oncotarget

Meng D,Chen Y,Yun D,Zhao Y,Wang J,Xu T,Li X,Wang Y,Yuan L,Sun R,Song X,Huai C,Hu L,Yang S,Min T,Chen J,Chen H,Lu D

Tue Mar 10 00:00:00 EDT 2015

Study on the Dynamic Biological Characteristics of Sca-1(+) Hematopoietic Stem and Progenitor Cell Senescence.

Stem cells international

Geng S,Mu XY,Chen XB,Hou JY,Jia DY,Xu CY,Wang YP

Wed Jun 24 00:00:00 EDT 2015

USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.

International journal of oncology

Ning Z,Wang A,Liang J,Xie Y,Liu J,Feng L,Yan Q,Wang Z

Wed Oct 01 00:00:00 EDT 2014

USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via β-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.

International journal of oncology

Ning Z,Wang A,Liang J,Xie Y,Liu J,Feng L,Yan Q,Wang Z

Wed Oct 01 00:00:00 EDT 2014

Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.

Oncology reports

Sun Q,Wang R,Wang Y,Luo J,Wang P,Cheng B

Sat Feb 01 00:00:00 EST 2014

Notch1 is a potential therapeutic target for the treatment of human hepatitis B virus X protein-associated hepatocellular carcinoma.

Oncology reports

Sun Q,Wang R,Wang Y,Luo J,Wang P,Cheng B

Sat Feb 01 00:00:00 EST 2014

Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma.

Journal of experimental & clinical cancer research : CR

Lv Z,Wu X,Cao W,Shen Z,Wang L,Xie F,Zhang J,Ji T,Yan M,Chen W

Thu Dec 18 00:00:00 EST 2014

Parathyroid hormone-related protein serves as a prognostic indicator in oral squamous cell carcinoma.

Journal of experimental & clinical cancer research : CR

Lv Z,Wu X,Cao W,Shen Z,Wang L,Xie F,Zhang J,Ji T,Yan M,Chen W

Thu Dec 18 00:00:00 EST 2014

Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma.

Journal of experimental & clinical cancer research : CR

Zhu X,Xu JJ,Hu SS,Feng JG,Jiang LH,Hou XX,Cao J,Han J,Ling ZQ,Ge MH

Wed Dec 31 00:00:00 EST 2014

Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma.

Journal of experimental & clinical cancer research : CR

Zhu X,Xu JJ,Hu SS,Feng JG,Jiang LH,Hou XX,Cao J,Han J,Ling ZQ,Ge MH

Wed Dec 31 00:00:00 EST 2014

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.

PloS one

Shan X,Fu YS,Aziz F,Wang XQ,Yan Q,Liu JW

Thu Dec 17 00:00:00 EST 2015

Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.

PloS one

Shan X,Fu YS,Aziz F,Wang XQ,Yan Q,Liu JW

Thu Dec 17 00:00:00 EST 2015

Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom.

The Journal of biological chemistry

Song Y,Gong K,Yan H,Hong W,Wang L,Wu Y,Li W,Li W,Cao Z

Fri Apr 25 00:00:00 EDT 2014

Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom.

The Journal of biological chemistry

Song Y,Gong K,Yan H,Hong W,Wang L,Wu Y,Li W,Li W,Cao Z

Fri Apr 25 00:00:00 EDT 2014

C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hu HM,Chen Y,Liu L,Zhang CG,Wang W,Gong K,Huang Z,Guo MX,Li WX,Li W

Tue Jan 01 00:00:00 EST 2013

C1orf61 acts as a tumor activator in human hepatocellular carcinoma and is associated with tumorigenesis and metastasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hu HM,Chen Y,Liu L,Zhang CG,Wang W,Gong K,Huang Z,Guo MX,Li WX,Li W

Tue Jan 01 00:00:00 EST 2013

Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.

Journal of cellular and molecular medicine

Wang Z,Liu F,Tu W,Chang Y,Yao J,Wu W,Jiang X,He X,Lin J,Song Y

Sun Jan 01 00:00:00 EST 2012

Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis.

Journal of cellular and molecular medicine

Wang Z,Liu F,Tu W,Chang Y,Yao J,Wu W,Jiang X,He X,Lin J,Song Y

Sun Jan 01 00:00:00 EST 2012

Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.

Journal of cellular and molecular medicine

Zhang Y,Fei M,Xue G,Zhou Q,Jia Y,Li L,Xin H,Sun S

Wed Feb 01 00:00:00 EST 2012

Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease.

Journal of cellular and molecular medicine

Zhang Y,Fei M,Xue G,Zhou Q,Jia Y,Li L,Xin H,Sun S

Wed Feb 01 00:00:00 EST 2012

Bioinformatics

Protein Aliases: Cell division protein kinase 4; CRK3; cyclin dependent kinase 4; Cyclin-dependent kinase 4; MGC14458; p34/cdk4; PSK-J3; serine/threonine kinase

View more View less

Gene Aliases: CDK4; CMM3; Crk3; PSK-J3

View more View less

UniProt ID: (Human) P11802, (Rat) P35426, (Mouse) P30285

View more View less

Entrez Gene ID: (Human) 1019, (Rat) 94201, (Mouse) 12567

View more View less

Function(s)

cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding cyclin-dependent protein serine/threonine kinase regulator activity cyclin binding protein complex binding protein kinase activity kinase activity nucleotide binding protein serine/threonine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

Process(es)

G1/S transition of mitotic cell cycle lens development in camera-type eye protein phosphorylation signal transduction circadian rhythm positive regulation of cell proliferation response to toxic substance response to lead ion regulation of gene expression positive regulation of G2/M transition of mitotic cell cycle organ regeneration response to testosterone response to drug positive regulation of apoptotic process positive regulation of translation positive regulation of cell cycle positive regulation of cell size regulation of protein kinase activity positive regulation of fibroblast proliferation cell division response to hyperoxia negative regulation of cell cycle arrest response to organic substance regulation of cell proliferation regulation of cell cycle cell cycle phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

CDK4 Polyclonal Antibody

CDK4 Antibody (11026-1-AP) in ICC/IF

Product Details

11026-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!