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CTHRC1 Polyclonal Antibody

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Antibody Testing Data (10)

CTHRC1 Antibody in Immunocytochemistry (ICC/IF)

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CTHRC1 Antibody (16534-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed A375 cells using 16534-1-AP (CTHRC1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CTHRC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CTHRC1 Antibody in Immunoprecipitation (IP)

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Product Details

16534-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CTHRC1 Fusion Protein Ag9812 (1-243 aa encoded by BC014245)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRPQGPAAS PQRLRGLLLL LLLQLPAPSS ASEIPKGKQK AQLRQREVVD LYNGMCLQGP AGVPGRDGSP GANGIPGTPG IPGRDGFKGE KGECLRESFE ESWTPNYKQC SWSSLNYGID LGKIAECTFT KMRSNSALRV LFSGSLRLKC RNACCQRWYF TFNGAECSGP LPIEAIIYLD QGSPEMNSTI NIHRTSSVEG LCEGIGAGLV DVAIWVGTCS DYPKGDASTG WNSVSRIIIE ELPK (1-243 aa encoded by BC014245)

Target Information

The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.

Inflammation

Feng Y,Hu J,Liu F,Shang Y

Thu Jun 01 00:00:00 EDT 2023

Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.

Inflammation

Feng Y,Hu J,Liu F,Shang Y

Thu Jun 01 00:00:00 EDT 2023

Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.

Inflammation

Feng Y,Hu J,Liu F,Shang Y

Thu Jun 01 00:00:00 EDT 2023

Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.

Inflammation

Feng Y,Hu J,Liu F,Shang Y

Thu Jun 01 00:00:00 EDT 2023

CTHRC1 is associated with immune cell infiltration and functions as an adverse marker for prognosis in head and neck squamous cell carcinoma.

Oncology letters

Zhong R,Yang M,Zhu R,Zhang J,Wang L

Sat Apr 01 00:00:00 EDT 2023

Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.

EBioMedicine

Jyothula SSK,Peters A,Liang Y,Bi W,Shivshankar P,Yau S,Garcha PS,Yuan X,Akkanti B,Collum S,Wareing N,Thandavarayan RA,Poli de Frias F,Rosas IO,Zhao B,Buja LM,Eltzschig HK,Huang HJ,Karmouty-Quintana H

Thu Dec 01 00:00:00 EST 2022

Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.

EBioMedicine

Jyothula SSK,Peters A,Liang Y,Bi W,Shivshankar P,Yau S,Garcha PS,Yuan X,Akkanti B,Collum S,Wareing N,Thandavarayan RA,Poli de Frias F,Rosas IO,Zhao B,Buja LM,Eltzschig HK,Huang HJ,Karmouty-Quintana H

Thu Dec 01 00:00:00 EST 2022

The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets.

Frontiers in genetics

Zhao L,Wang W,Niu P,Luan X,Zhao D,Chen Y

Sat Aug 06 00:00:00 EDT 2022

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.

Cells

Li H,Peng H,Hong W,Wei Y,Tian H,Huang X,Jia L,Zheng J,Duan T,He Q,Wang K

Sun Dec 25 00:00:00 EST 2022

Single-cell landscape reveals active cell subtypes and their interaction in the tumor microenvironment of gastric cancer.

Theranostics

Li Y,Hu X,Lin R,Zhou G,Zhao L,Zhao D,Zhang Y,Li W,Zhang Y,Ma P,Ren H,Liao X,Niu P,Wang T,Zhang X,Wang W,Gao R,Li Q,Church G,He J,Chen Y

Wed Jun 08 00:00:00 EDT 2022

miR-509-3p Suppresses Migration, Invasion, and Epithelial- Mesenchymal Transition in Melanoma Cells by Targeting Collagen Triple Helix Repeat Containing 1.

Balkan medical journal

Yuan K,Sun Y,Ji Y

Sat May 01 00:00:00 EDT 2021

MicroRNA Hsa-Let-7b Regulates the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting CTHRC1.

Stem cells international

Fu L,Li N,Ye Y,Ye X,Xiao T,Wu X,Ma Y,Yu J

Sat Dec 25 00:00:00 EST 2021

Hyperdense Pancreatic Ductal Adenocarcinoma: Clinical Characteristics and Proteomic Landscape.

Frontiers in oncology

Xu H,Hua J,Meng Q,Wang X,Xu J,Wang W,Zhang B,Liu J,Liang C,Yu X,Shi S

Thu Apr 21 00:00:00 EDT 2022

Identification of Overexpressed Genes in Malignant Pleural Mesothelioma.

International journal of molecular sciences

Morani F,Bisceglia L,Rosini G,Mutti L,Melaiu O,Landi S,Gemignani F

Mon Mar 08 00:00:00 EST 2021

NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.

International journal of biological sciences

Chen L,Yang Y,Yan H,Peng X,Zou J

Tue Feb 22 00:00:00 EST 2022

NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.

International journal of biological sciences

Chen L,Yang Y,Yan H,Peng X,Zou J

Tue Feb 22 00:00:00 EST 2022

CTHRC1 in Ovarian Cancer Promotes M2-Like Polarization of Tumor-Associated Macrophages via Regulation of the STAT6 Signaling Pathway.

OncoTargets and therapy

Bai Y,Yin K,Su T,Ji F,Zhang S

Fri Apr 15 00:00:00 EDT 2022

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.

International journal of oncology

Jiang F,Chen Y,Ren S,Li Z,Sun K,Xing Y,Zhu Y,Piao D

Wed Jul 01 00:00:00 EDT 2020

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.

International journal of oncology

Jiang F,Chen Y,Ren S,Li Z,Sun K,Xing Y,Zhu Y,Piao D

Wed Jul 01 00:00:00 EDT 2020

CTHRC1 affects malignant tumor cell behavior and is regulated by miR-30e-5p in human prostate cancer.

Biochemical and biophysical research communications

Ma Z,Chao F,Wang S,Song Z,Zhuo Z,Zhang J,Xu G,Chen G

Thu Apr 30 00:00:00 EDT 2020

CTHRC1 affects malignant tumor cell behavior and is regulated by miR-30e-5p in human prostate cancer.

Biochemical and biophysical research communications

Ma Z,Chao F,Wang S,Song Z,Zhuo Z,Zhang J,Xu G,Chen G

Thu Apr 30 00:00:00 EDT 2020

CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma.

OncoTargets and therapy

Zhou H,Su L,Liu C,Li B,Li H,Xie Y,Sun D

Sun Apr 10 00:00:00 EDT 2022

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.

Respiratory research

Jin J,Togo S,Kadoya K,Tulafu M,Namba Y,Iwai M,Watanabe J,Nagahama K,Okabe T,Hidayat M,Kodama Y,Kitamura H,Ogura T,Kitamura N,Ikeo K,Sasaki S,Tominaga S,Takahashi K

Tue Jun 11 00:00:00 EDT 2019

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1.

Respiratory research

Jin J,Togo S,Kadoya K,Tulafu M,Namba Y,Iwai M,Watanabe J,Nagahama K,Okabe T,Hidayat M,Kodama Y,Kitamura H,Ogura T,Kitamura N,Ikeo K,Sasaki S,Tominaga S,Takahashi K

Tue Jun 11 00:00:00 EDT 2019

CTHRC1 promotes M2-like macrophage recruitment and myometrial invasion in endometrial carcinoma by integrin-Akt signaling pathway.

Clinical & experimental metastasis

Li LY,Yin KM,Bai YH,Zhang ZG,Di W,Zhang S

Thu Aug 01 00:00:00 EDT 2019

CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling.

International journal of molecular medicine

Zhang Q,Yin ZS,Zhang FW,Cao K,Sun HY

Sun Apr 01 00:00:00 EDT 2018

CTHRC1 mediates IL‑1β‑induced apoptosis in chondrocytes via JNK1/2 signaling.

International journal of molecular medicine

Zhang Q,Yin ZS,Zhang FW,Cao K,Sun HY

Sun Apr 01 00:00:00 EDT 2018

Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer.

Journal of ovarian research

Guo B,Yan H,Li L,Yin K,Ji F,Zhang S

Wed Oct 11 00:00:00 EDT 2017

Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer.

Journal of ovarian research

Guo B,Yan H,Li L,Yin K,Ji F,Zhang S

Wed Oct 11 00:00:00 EDT 2017

Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer.

Journal of ovarian research

Guo B,Yan H,Li L,Yin K,Ji F,Zhang S

Wed Oct 11 00:00:00 EDT 2017

Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer.

Journal of ovarian research

Guo B,Yan H,Li L,Yin K,Ji F,Zhang S

Wed Oct 11 00:00:00 EDT 2017

Lentivirus-Mediated Knockdown of CTHRC1 Inhibits Osteosarcoma Cell Proliferation and Migration.

Cancer biotherapy & radiopharmaceuticals

Sang W,Zhu L,Ma J,Lu H,Wang C

Fri Apr 01 00:00:00 EDT 2016

Lentivirus-Mediated Knockdown of CTHRC1 Inhibits Osteosarcoma Cell Proliferation and Migration.

Cancer biotherapy & radiopharmaceuticals

Sang W,Zhu L,Ma J,Lu H,Wang C

Fri Apr 01 00:00:00 EDT 2016

SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1.

American journal of cancer research

Yan L,Yu J,Tan F,Ye GT,Shen ZY,Liu H,Zhang Y,Wang JF,Zhu XJ,Li GX

Tue Jun 23 00:00:00 EDT 2015

SP1-mediated microRNA-520d-5p suppresses tumor growth and metastasis in colorectal cancer by targeting CTHRC1.

American journal of cancer research

Yan L,Yu J,Tan F,Ye GT,Shen ZY,Liu H,Zhang Y,Wang JF,Zhu XJ,Li GX

Tue Jun 23 00:00:00 EDT 2015

MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury.

Journal of cell science

Zhou S,Gao R,Hu W,Qian T,Wang N,Ding G,Ding F,Yu B,Gu X

Sat Mar 01 00:00:00 EST 2014

MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury.

Journal of cell science

Zhou S,Gao R,Hu W,Qian T,Wang N,Ding G,Ding F,Yu B,Gu X

Sat Mar 01 00:00:00 EST 2014

MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury.

Journal of cell science

Zhou S,Gao R,Hu W,Qian T,Wang N,Ding G,Ding F,Yu B,Gu X

Sat Mar 01 00:00:00 EST 2014

MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury.

Journal of cell science

Zhou S,Gao R,Hu W,Qian T,Wang N,Ding G,Ding F,Yu B,Gu X

Sat Mar 01 00:00:00 EST 2014

Bioinformatics

Protein Aliases: Collagen triple helix repeat-containing protein 1

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Gene Aliases: 1110014B07Rik; CTHRC1; UNQ762/PRO1550

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UniProt ID: (Human) Q96CG8, (Mouse) Q9D1D6, (Rat) Q8CG08

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Entrez Gene ID: (Human) 115908, (Mouse) 68588, (Rat) 282836

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Function(s)

frizzled binding Wnt-protein binding protein binding oxygenase

Process(es)

cell migration positive regulation of protein binding positive regulation of osteoblast proliferation ossification involved in bone remodeling positive regulation of osteoblast differentiation Wnt signaling pathway, planar cell polarity pathway inner ear receptor stereocilium organization negative regulation of canonical Wnt signaling pathway cochlea morphogenesis establishment of planar polarity involved in neural tube closure

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CTHRC1 Polyclonal Antibody

CTHRC1 Antibody (16534-1-AP) in ICC/IF

Product Details

16534-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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