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Immunogen sequence: MLEKLMGAD SLQLFRSRYT LGKIYFIGFQ RSILLSKSEN SLNSIAKETE EGRETVTRKE GWKRRHEDGY LEMAQRHLQR SLCPWVSYLP QPYAELEEVS SHVGKVFMAR NYEFLAYEAS KDRRQPLERM WTCNYNQQKD QSCNHKEITS TKAE (1-153 aa encoded by BC121091)
This gene encodes a protein that is an activator of the FAD-dependent enzyme D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder, possibly due to decreased levels of D-serine and decreased NMDA receptor functioning. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: D-amino acid oxidase regulator; G72 transcript; Protein G72; schizophrenia- and bipolar disorder-associated protein G72
Gene Aliases: DAOA; G72; LG72; SG72
UniProt ID: (Human) P59103
Entrez Gene ID: (Human) 267012
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