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GABA(A) beta 2 Receptor Antibody (AGA-012-200UL) in IHC (F)
Expression of GABA (A) Receptor Beta 2 in mouse hypothalamus. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections Anti-GABA (A) beta 2 Receptor Antibody (#AGA-012), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. Staining in the periventricular hypothalamus region, showed GABA (A) Receptor Beta 2 immunoreactivity (green) in periventricular glial processes (arrows). B. Pre-in... View More
Product Details
AGA-012-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KAGLPRHSFGRNALE, corresponding to amino acid residues 405-419 of rat GABRB2, Intracellular, 2nd loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; GABAARbeta2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor beta-2 subunit; Gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor, subunit beta 2; MGC119386; MGC119388; MGC119389
Gene Aliases: AI834970; C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2; GABRB2; GARB2
UniProt ID: (Human) P47870, (Mouse) P63137, (Rat) P63138
Entrez Gene ID: (Human) 2561, (Mouse) 14401, (Rat) 25451
transport
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
sensory perception of sound
ion transmembrane transport
negative regulation of neuron apoptotic process
synaptic transmission, GABAergic
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
chloride transmembrane transport
ion transport
chloride transport
signal transduction
regulation of neuron apoptotic process
neuron development
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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