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Product Details
PA1-4727
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein from the cytoplasmic loop of the beta 2 subunit of rat GABRB2
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2278880
Product Specific Information
This antibody is predicted to react with canine, human, mouse, non-human primate based on 100% sequence homology.
Target Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; GABAARbeta2; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid A receptor, subunit beta 2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid receptor beta-2 subunit; Gamma-aminobutyric acid receptor subunit beta-2; gamma-aminobutyric acid receptor, subunit beta 2; MGC119386; MGC119388; MGC119389
Gene Aliases: AI834970; C030002O17Rik; C030021G16Rik; Gabrab2; Gabrb-2; Gabrb2; GARB2
UniProt ID: (Mouse) P63137, (Rat) P63138
Entrez Gene ID: (Mouse) 14401, (Rat) 25451
transport
ion transport
chloride transport
signal transduction
sensory perception of sound
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
neuron development
synaptic transmission, GABAergic
inner ear receptor cell development
innervation
cellular response to histamine
cochlea development
negative regulation of neuron death
chloride transmembrane transport
gamma-aminobutyric acid signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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