Proteintech

GAPDH Monoclonal Antibody (1E6D9), HRP

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Antibody Testing Data (2)

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GAPDH Antibody (HRP-60004) in WB

HeLa cells were subjected to SDS PAGE followed by western blot with HRP-60004 (GAPDH antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours.

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Product Details

HRP-60004

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 470 publications 470 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Not applicable (N/A)

View 16 publications 16 publications

Product Specifications

Species Reactivity

Human, Mouse, Plant, Rat, Zebrafish

Published species

Hamster, Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1E6D9

Immunogen

Recombinant protein

Conjugate

HRP HRP HRP

Form

Liquid

Concentration

0.67 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.02% thimerosal, 0.05% ProClin 300

Storage conditions

-20° C, store in dark

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is raised against full length GAPDH of human origin. It can recognize the 36 kDa GAPDH protein in most cells/tissues. In addition, a band below 36 kDa can always be detected as the isoform or spliced product of GAPDH. Please note that some physiological factors, such as hypoxia and diabetes, increase GAPDH expression in certain cell types.

Target Information

GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is a catalytic enzyme commonly known to be involved in glycolysis. GAPDH exists as a tetramer of identical 37-kDa subunits and catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Apart from playing a key role in glycolysis, GAPDH is ubiquitously expressed and displays other activities unrelated to its glycolytic function. GAPDH is reported to be involved in the processes of DNA replication, DNA repair, nuclear RNA export, membrane fusion and microtubule bundling. Studies provide evidence of GAPDH playing an essential part in gene expression observed in apoptosis and as part of the cellular phenotype of age-related neurodegenerative diseases. Further, GAPDH is involved in other cellular processes ranging from membrane fusion, and neuronal apoptosis in cancer. GAPDH is reported to bind to a variety of other proteins, including the amyloid precursor protein, mutations in which cause some forms of Alzheimer's disease (AD), and the polyglutamine tracts of Huntingtin, the protein product aberrant forms of which are causative of Huntington's disease. Associations between GAPDH, actin and tubulin have also be reported. Since GAPDH is expressed at high levels in most tissues, it is useful as protein loading control in Western Blot analysis.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Keppeke GD,Diogenes L,Gomes K,Andrade LEC

Thu Jun 01 00:00:00 EDT 2023

CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.

Oncogene

Zeng W,Xiong L,Wu W,Li S,Liu J,Yang L,Lao L,Huang P,Zhang M,Chen H,Miao N,Lin Z,Liu Z,Yang X,Wang J,Wang P,Song E,Yao Y,Nie Y,Chen J,Huang D

Sun Jan 01 00:00:00 EST 2023

Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.

Biological trace element research

Fang Z,Li Y,Wang J,Wang X,Huang L,Sun L,Deng Q

Fri Sep 01 00:00:00 EDT 2023

Partial Truncation of the C-Terminal Domain of PTCH1 in Cancer Enhances Autophagy and Metabolic Adaptability.

Cancers

Caballero-Ruiz B,Gkotsi DS,Ollerton H,Morales-Alcala CC,Bordone R,Jenkins GML,Di Magno L,Canettieri G,Riobo-Del Galdo NA

Fri Jan 06 00:00:00 EST 2023

PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

He Y,B'nai Taub A,Yu L,Yao Y,Zhang R,Zahr T,Aaron N,LeSauter J,Fan L,Liu L,Tazebay R,Que J,Pajvani U,Wang L,Silver R,Qiang L

Sun Jan 01 00:00:00 EST 2023

The Effect of Cholesterol Efflux on Endothelial Dysfunction Caused by Oxidative Stress.

International journal of molecular sciences

Ye H,Liu Q,Wang Y,Zhen X,Yan N

Tue Mar 21 00:00:00 EDT 2023

Mitotic spindle positioning protein (MISP) deficiency exacerbates dextran sulfate sodium (DSS)-induced colitis in mice.

The Journal of veterinary medical science

Hiura K,Maruyama T,Watanabe M,Nakano K,Okamura T,Sasaki H,Sasaki N

Wed Feb 01 00:00:00 EST 2023

Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH.

Cardiovascular research

Wilson AD,Richards MA,Curtis MK,Gunadasa-Rohling M,Monterisi S,Loonat AA,Miller JJ,Ball V,Lewis A,Tyler DJ,Moshnikova A,Andreev OA,Reshetnyak YK,Carr C,Swietach P

Thu Nov 10 00:00:00 EST 2022

RICH1 inhibits breast cancer stem cell traits through activating kinases cascade of Hippo signaling by competing with Merlin for binding to Amot-p80.

Cell death & disease

Tian Q,Gao H,Zhou Y,Zhu L,Yang J,Wang B,Liu P,Yang J

Fri Jan 21 00:00:00 EST 2022

7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice.

Neurobiology of disease

Tian Y,Pan L,Yuan X,Xiong M,Zhang Z,Meng L,Zheng Y,Bu L,Xu X,Zhang Z

Fri Jul 01 00:00:00 EDT 2022

Quercetin Ameliorates Renal Injury and Pyroptosis in Lupus Nephritis through Inhibiting IL-33/ST2 Pathway In Vitro and In Vivo.

Antioxidants (Basel, Switzerland)

Chen HY,Chiang YF,Hong YH,Shieh TM,Huang TC,Ali M,Chang HY,Wang KL,Hsia SM

Sun Nov 13 00:00:00 EST 2022

Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.

Pharmacological research

Tang K,Qin W,Wei R,Jiang Y,Fan L,Wang Z,Tan N

Sun May 01 00:00:00 EDT 2022

Defining the Skeletal Myogenic Lineage in Human Pluripotent Stem Cell-Derived Teratomas.

Cells

Pappas MP,Xie N,Penaloza JS,Chan SSK

Mon May 09 00:00:00 EDT 2022

Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis.

Cells

Zhang Z,Ji C,Wang YN,Liu S,Wang M,Xu X,Zhang D

Wed Aug 17 00:00:00 EDT 2022

Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.

Journal of translational medicine

Wang J,Zhou L,Chen B,Yu Z,Zhang J,Zhang Z,Hu C,Bai Y,Ruan X,Wang S,Ouyang J,Wu A,Zhao X

Mon Jan 31 00:00:00 EST 2022

Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress.

Journal of the European Academy of Dermatology and Venereology : JEADV

Li W,Li QL,Xu QY,Wang XT,Yang TC

Tue Nov 01 00:00:00 EDT 2022

C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells.

Cellular and molecular life sciences : CMLS

Chen X,Ji Y,Feng F,Liu Z,Qian L,Shen H,Lao L

Thu Jul 21 00:00:00 EDT 2022

Suppression of macrophage-mediated xenogeneic rejection by the ectopic expression of human CD177.

Transplant immunology

Kogata S,Lo PC,Maeda A,Okamatsu C,Sato K,Yamamoto R,Haneda T,Yoneyama T,Toyama C,Eguchi H,Masahata K,Kamiyama M,Okuyama H,Miyagawa S

Sat Oct 01 00:00:00 EDT 2022

The Role of ATF3 in Neuronal Differentiation and Development of Neuronal Networks in Opossum Postnatal Cortical Cultures.

International journal of molecular sciences

Petrović A,Ban J,Ivaničić M,Tomljanović I,Mladinic M

Fri Apr 29 00:00:00 EDT 2022

Tau accelerates α-synuclein aggregation and spreading in Parkinson's disease.

Brain : a journal of neurology

Pan L,Li C,Meng L,Tian Y,He M,Yuan X,Zhang G,Zhang Z,Xiong J,Chen G,Zhang Z

Fri Oct 21 00:00:00 EDT 2022

The Combined Inactivation of Intestinal and Hepatic ZIP14 Exacerbates Manganese Overload in Mice.

International journal of molecular sciences

Fung CK,Zhao N

Fri Jun 10 00:00:00 EDT 2022

Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification.

Pharmacological research

Guo Q,Zhang YC,Wang W,Wang YQ,Liu Y,Yang Z,Zhao MM,Feng N,Wang YH,Zhang XW,Yang H,Liu TT,Shi LY,Shi XM,Liu D,Tu PF,Zeng KW

Tue Feb 01 00:00:00 EST 2022

Coronin2A links actin-based endosomal processes to the EHD1 fission machinery.

Molecular biology of the cell

Dhawan K,Naslavsky N,Caplan S

Sat Oct 01 00:00:00 EDT 2022

Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury.

Frontiers in immunology

Jiang F,Xia M,Zhang Y,Chang J,Cao J,Zhang Z,Qian Z,Yang L

Mon Oct 17 00:00:00 EDT 2022

A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability.

Cancer communications (London, England)

Wang J,Shao F,Yang Y,Wang W,Yang X,Li R,Cheng H,Sun S,Feng X,Gao Y,He J,Lu Z

Sat Oct 01 00:00:00 EDT 2022

Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition.

Annals of translational medicine

Mo S,Fang D,Zhao S,Thai Hoa PT,Zhou C,Liang T,He Y,Yu T,Chen Y,Qin W,Han Q,Su H,Zhu G,Luo X,Peng T,Han C

Tue Feb 01 00:00:00 EST 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction.

Cell death & disease

Wang H,Lv D,Jiang S,Hou Q,Zhang L,Li S,Zhu X,Xu X,Wen J,Zeng C,Zhang M,Yang F,Chen Z,Zheng C,Li J,Zen K,Liu Z,Li L

Tue Mar 29 00:00:00 EDT 2022

Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.

Journal of bone and mineral metabolism

Kaneko T,Horiuchi K,Chijimatsu R,Mori D,Nagata K,Omata Y,Yano F,Inui H,Moro T,Tanaka S,Saito T

Tue Mar 01 00:00:00 EST 2022

CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.

Experimental eye research

Wang Y,Jin C,Tian H,Xu J,Chen J,Hu S,Li Q,Lu L,Ou Q,Xu GT,Cui H

Wed Jun 01 00:00:00 EDT 2022

Identification of SLC3A2 as a Potential Therapeutic Target of Osteoarthritis Involved in Ferroptosis by Integrating Bioinformatics, Clinical Factors and Experiments.

Cells

Liu H,Deng Z,Yu B,Liu H,Yang Z,Zeng A,Fu M

Sun Oct 30 00:00:00 EDT 2022

DEAD-box helicase 56 functions as an oncogene promote cell proliferation and invasion in gastric cancer via the FOXO1/p21 Cip1/c-Myc signaling pathway.

Bioengineered

Wang J,Wang Y,Wang J,Zhang S,Yu Z,Zheng K,Fu Z,Wang C,Huang W,Chen J

Sun May 01 00:00:00 EDT 2022

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.

eLife

Monterisi S,Michl J,Hulikova A,Koth J,Bridges EM,Hill AE,Abdullayeva G,Bodmer WF,Swietach P

Thu Sep 15 00:00:00 EDT 2022

Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.

Nucleic acids research

Zhang Q,Wang S,Li W,Yau E,Hui H,Singh PK,Achuthan V,Young Karris MA,Engelman AN,Rana TM

Fri Jul 08 00:00:00 EDT 2022

Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis.

Cell death & disease

Soliman HAN,Toso EA,Darwish IE,Ali SM,Kyba M

Mon Apr 25 00:00:00 EDT 2022

Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.

The EMBO journal

Shu Y,Hao Y,Feng J,Liu H,Li ST,Feng J,Jiang Z,Ye L,Zhou Y,Sun Y,Zhou Z,Wei H,Gao P,Zhang H,Sun L

Thu Dec 01 00:00:00 EST 2022

Excessive activation of HOXB13/PIMREG axis promotes hepatocellular carcinoma progression and drug resistance.

Biochemical and biophysical research communications

Tang C,Qiu S,Mou W,Xu J,Wang P

Sat Oct 01 00:00:00 EDT 2022

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma.

Cancer research

Sen A,Prager BC,Zhong C,Park D,Zhu Z,Gimple RC,Wu Q,Bernatchez JA,Beck S,Clark AE,Siqueira-Neto JL,Rich JN,McVicker G

Tue Feb 01 00:00:00 EST 2022

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.

eLife

Li J,Huang D,Lei B,Huang J,Yang L,Nie M,Su S,Zhao Q,Wang Y

Fri Dec 09 00:00:00 EST 2022

The DEAD-box helicase DDX3x ameliorates non-alcoholic fatty liver disease via mTORC1 signalling pathway.

Liver international : official journal of the International Association for the Study of the Liver

Liu P,Zhang Y,Tang C,Cen L,Chen Y,Li S,Chen X,Yu M,Zhang J,Zhang X,Zeng H,Xu C,Yu C

Mon Aug 01 00:00:00 EDT 2022

MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse.

Molecular biology reports

Wang X,Yang Y,Chen Y,Duan Y,Han J,Yang X

Fri Jul 01 00:00:00 EDT 2022

E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.

Cell death & disease

Chen M,Zhao Z,Wu L,Huang J,Yu P,Qian J,Ni T,Zhao C

Mon Sep 12 00:00:00 EDT 2022

Pervasive translation of circular RNAs driven by short IRES-like elements.

Nature communications

Fan X,Yang Y,Chen C,Wang Z

Wed Jun 29 00:00:00 EDT 2022

Effects of Rice-Husk Silica Liquid in Streptozotocin-Induced Diabetic Mice.

Metabolites

Chen HY,Hong YH,Chiang YF,Wang KL,Huang TC,Ali M,Shieh TM,Chang HY,Hsia SM

Wed Oct 12 00:00:00 EDT 2022

DSCAM-AS1 Long Non-Coding RNA Exerts Oncogenic Functions in Endometrial Adenocarcinoma via Activation of a Tumor-Promoting Transcriptome Profile.

Biomedicines

Treeck O,Weber F,Fritsch J,Skrzypczak M,Schüler-Toprak S,Buechler C,Ortmann O

Mon Jul 18 00:00:00 EDT 2022

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH.

Cell reports

Michl J,Wang Y,Monterisi S,Blaszczak W,Beveridge R,Bridges EM,Koth J,Bodmer WF,Swietach P

Tue Mar 08 00:00:00 EST 2022

Microbial metabolite restricts 5-fluorouracil-resistant colonic tumor progression by sensitizing drug transporters via regulation of FOXO3-FOXM1 axis.

Theranostics

Ghosh S,Singh R,Vanwinkle ZM,Guo H,Vemula PK,Goel A,Haribabu B,Jala VR

Tue Aug 02 00:00:00 EDT 2022

Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI.

Brain research

Yu D,Zhao XY,Meng QP,Teng D,Deng K,Lin N

Thu Dec 01 00:00:00 EST 2022

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.

Cell death & disease

Gao Y,Fang Y,Huang Y,Ma R,Chen X,Wang F,Pei X,Gao Y,Chen X,Liu X,Shan J,Li P

Wed Sep 21 00:00:00 EDT 2022

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.

Cell death & disease

Gao Y,Fang Y,Huang Y,Ma R,Chen X,Wang F,Pei X,Gao Y,Chen X,Liu X,Shan J,Li P

Wed Sep 21 00:00:00 EDT 2022

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.

Cell death & disease

Gao Y,Fang Y,Huang Y,Ma R,Chen X,Wang F,Pei X,Gao Y,Chen X,Liu X,Shan J,Li P

Wed Sep 21 00:00:00 EDT 2022

Autoregulation of H⁺/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.

British journal of cancer

Blaszczak W,Williams H,Swietach P

Sat Oct 01 00:00:00 EDT 2022

Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome-induced pyroptosis.

Frontiers in immunology

Wang C,Ma H,Zhang B,Hua T,Wang H,Wang L,Han L,Li Q,Wu W,Sun Y,Yang H,Lu X

Tue Aug 23 00:00:00 EDT 2022

Single-cell transcriptional profiling reveals heterogeneity and developmental trajectories of Ewing sarcoma.

Journal of cancer research and clinical oncology

Hong B,Li Y,Yang R,Dai S,Zhan Y,Zhang WB,Dong R

Thu Dec 01 00:00:00 EST 2022

Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.

Cancers

Buchou C,Laud-Duval K,van der Ent W,Grossetête S,Zaidi S,Gentric G,Corbé M,Müller K,Del Nery E,Surdez D,Delattre O

Sun May 08 00:00:00 EDT 2022

A functional PVA aerogel-based membrane obtaining sutureability through modified electrospinning technology and achieving promising anti-adhesion effect after cardiac surgery.

Bioactive materials

Jin D,Yang S,Wu S,Yin M,Kuang H

Fri Apr 01 00:00:00 EDT 2022

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma.

Scientific reports

Ganesa S,Sule A,Sundaram RK,Bindra RS

Wed Apr 06 00:00:00 EDT 2022

Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes.

Journal of clinical immunology

Chen X,Chen J,Chen R,Mou H,Sun G,Yang L,Jia Y,Zhao Q,Wen W,Zhou L,Ding Y,Tang X,Yang J,An Y,Zhao X

Tue Nov 01 00:00:00 EDT 2022

Rational Design and Optimization of m⁶A-RNA Demethylase FTO Inhibitors as Anticancer Agents.

Journal of medicinal chemistry

Huff S,Kummetha IR,Zhang L,Wang L,Bray W,Yin J,Kelley V,Wang Y,Rana TM

Thu Aug 25 00:00:00 EDT 2022

Spirulina phycocyanin extract and its active components suppress epithelial-mesenchymal transition process in endometrial cancer via targeting TGF-beta1/SMAD4 signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen HY,Chiang YF,Huang CY,Shieh TM,Kao C,Chang FK,Huang TC,Ali M,Chang HY,Hong YH,Hsia SM

Mon Aug 01 00:00:00 EDT 2022

Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury.

International immunopharmacology

Xia M,Zhang Y,Wu H,Zhang Q,Liu Q,Li G,Zhao T,Liu X,Zheng S,Qian Z,Li H

Sat Oct 01 00:00:00 EDT 2022

Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy.

Redox biology

Liu C,Sun W,Zhu T,Shi S,Zhang J,Wang J,Gao F,Ou Q,Jin C,Li J,Xu JY,Zhang J,Tian H,Xu GT,Lu L

Wed Jun 01 00:00:00 EDT 2022

Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.

Traffic (Copenhagen, Denmark)

Jones T,Naslavsky N,Caplan S

Fri Jul 01 00:00:00 EDT 2022

Plasma-Based Metabolomics Profiling of High-Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer.

BioMed research international

Chen A,Xu M,Chen J,Chen T,Wang Q,Zhang R,Qiu J

Mon Nov 21 00:00:00 EST 2022

Suhuang antitussive capsule ameliorates post-infectious cough in mice through AhR-Nrf2 pathway.

Journal of ethnopharmacology

Liang R,Tong X,Dong Z,Qin W,Fan L,Bai Z,Zhang Z,Xiang T,Wang Z,Tan N

Sun Jan 30 00:00:00 EST 2022

Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.

Frontiers in immunology

Sun J,Wei J,Zhang Y,Li J,Li J,Yan J,Guo M,Han J,Qiao H

Mon May 02 00:00:00 EDT 2022

A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C.

Frontiers in cell and developmental biology

West G,Turunen M,Aalto A,Virtanen L,Li SP,Heliö T,Meinander A,Taimen P

Sat Jan 07 00:00:00 EST 2023

Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.

The Journal of biological chemistry

Wang X,Yang Y,Zhao D,Zhang S,Chen Y,Chen Y,Feng K,Li X,Han J,Iwakiri Y,Duan Y,Yang X

Tue Feb 01 00:00:00 EST 2022

Hypoxic preconditioning promotes galvanotaxis of human dermal microvascular endothelial cells through NF-κB pathway.

Heliyon

Zhang Z,Wu C,Yang J,Liu J,Liu L,Kong M,Zhang J,Jiang X

Thu Dec 01 00:00:00 EST 2022

Sexual dimorphic impacts of systemic vincristine on lower urinary tract function.

Scientific reports

Iguchi N,Hecht SL,Gao D,Wilcox DT,Malykhina AP,Cost NG

Thu Mar 24 00:00:00 EDT 2022

The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.

Life sciences

Suthapot P,Xiao T,Felsenfeld G,Hongeng S,Wongtrakoongate P

Tue Feb 15 00:00:00 EST 2022

CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.

Cell death and differentiation

Huang C,Du R,Jia X,Liu K,Qiao Y,Wu Q,Yao N,Yang L,Zhou L,Liu X,Xiang P,Xin M,Wang Y,Chen X,Kim DJ,Dong Z,Li X

Sat Jan 01 00:00:00 EST 2022

The retromer complex regulates C. elegans development and mammalian ciliogenesis.

Journal of cell science

Xie S,Dierlam C,Smith E,Duran R,Williams A,Davis A,Mathew D,Naslavsky N,Iyer J,Caplan S

Sun May 15 00:00:00 EDT 2022

UDP-glucose 6-dehydrogenase lessens sorafenib sensitivity via modulating unfolded protein response.

Biochemical and biophysical research communications

Guo B,Xu X,Shao M,Yang X,He G,Qi K,Gu J,Wang L

Tue Jul 12 00:00:00 EDT 2022

Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.

Skeletal muscle

Xiang G,Ying K,Jiang P,Jia M,Sun Y,Li S,Wu X,Hao S

Fri May 06 00:00:00 EDT 2022

Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.

Oncotarget

Ueno D,Vasquez JC,Sule A,Liang J,van Doorn J,Sundaram R,Friedman S,Caliliw R,Ohtake S,Bao X,Li J,Ye H,Boyd K,Huang RR,Dodson J,Boutros P,Bindra RS,Shuch B

Fri Sep 23 00:00:00 EDT 2022

FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.

Molecular medicine (Cambridge, Mass.)

Zhang Z,Xu Y

Tue Jul 19 00:00:00 EDT 2022

Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling.

Journal of oncology

Zhu M,Zhou L,Fu J,Wang Y,Xu X,Wu J,Kong X,Li J,Zhou Z,Zhou H

Wed Dec 07 00:00:00 EST 2022

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N⁶-methyladenosine.

Developmental cell

Lv D,Gimple RC,Zhong C,Wu Q,Yang K,Prager BC,Godugu B,Qiu Z,Zhao L,Zhang G,Dixit D,Lee D,Shen JZ,Li X,Xie Q,Wang X,Agnihotri S,Rich JN

Mon Jun 20 00:00:00 EDT 2022

The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability.

Experimental & molecular medicine

Zhang N,Shen Y,Li H,Chen Y,Zhang P,Lou S,Deng J

Tue Feb 01 00:00:00 EST 2022

Pangenomic analysis of Chinese gastric cancer.

Nature communications

Yu Y,Zhang Z,Dong X,Yang R,Duan Z,Xiang Z,Li J,Li G,Yan F,Xue H,Jiao D,Lu J,Lu H,Zhang W,Wei Y,Fan S,Li J,Jia J,Zhang J,Ji J,Liu P,Lu H,Zhao H,Chen S,Wei C,Chen H,Zhu Z

Thu Sep 15 00:00:00 EDT 2022

Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway.

Neuroscience letters

Hong X,Xia M,Zhang Q,Zhao T,Zhang Y,Qian Z,Bao J,Li H

Sun Nov 20 00:00:00 EST 2022

Proteomic analysis of opossum Monodelphis domestica spinal cord reveals the changes of proteins related to neurodegenerative diseases during developmental period when neuroregeneration stops being possible.

Biochemical and biophysical research communications

Tomljanović I,Petrović A,Ban J,Mladinic M

Sat Jan 08 00:00:00 EST 2022

Suppression of NRF2 Activity by HIF-1α Promotes Fibrosis after Ischemic Acute Kidney Injury.

Antioxidants (Basel, Switzerland)

Bondi CD,Rush BM,Hartman HL,Wang J,Al-Bataineh MM,Hughey RP,Tan RJ

Wed Sep 14 00:00:00 EDT 2022

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.

The Journal of experimental medicine

Campbell TM,Liu Z,Zhang Q,Moncada-Velez M,Covill LE,Zhang P,Alavi Darazam I,Bastard P,Bizien L,Bucciol G,Lind Enoksson S,Jouanguy E,Karabela ŞN,Khan T,Kendir-Demirkol Y,Arias AA,Mansouri D,Marits P,Marr N,Migeotte I,Moens L,Ozcelik T,Pellier I,Sendel A,Şenoğlu, S,Shahrooei M,Smith CIE,Vandernoot I,Willekens K,Kart Yaşar K,Bergman P,Abel L,Cobat A,Casanova JL,Meyts I,Bryceson YT

Mon Jul 04 00:00:00 EDT 2022

The Effect of TGF-β1 Reduced Functionality on the Expression of Selected Synaptic Proteins and Electrophysiological Parameters: Implications of Changes Observed in Acute Hepatic Encephalopathy.

International journal of molecular sciences

Popek M,Bobula B,Orzeł-Gajowik K,Zielińska M

Wed Jan 19 00:00:00 EST 2022

AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus.

The EMBO journal

Zheng X,Xiao J,Jiang Q,Zheng L,Liu C,Dong C,Zheng Y,Ni P,Zhang C,Zhang F,Zhong R,Ding H,Wang Q,Qiu Y,Gao M,Ding J,Shen N,Wei B,Wang H

Tue Mar 15 00:00:00 EDT 2022

AKT serine/threonine kinase 2-mediated phosphorylation of fascin threonine 403 regulates esophageal cancer progression.

The international journal of biochemistry & cell biology

Zhang ZD,Wen B,Li DJ,Deng DX,Wu XD,Cheng YW,Liao LD,Long L,Dong G,Xu LY,Li EM

Fri Apr 01 00:00:00 EDT 2022

Direct targeting of amplified gene loci for proapoptotic anticancer therapy.

Nature biotechnology

Kaushik Tiwari M,Colon-Rios DA,Tumu HCR,Liu Y,Quijano E,Krysztofiak A,Chan C,Song E,Braddock DT,Suh HW,Saltzman WM,Rogers FA

Tue Mar 01 00:00:00 EST 2022

Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury.

International journal of biological sciences

Qian Z,Chen H,Xia M,Chang J,Li X,Ye S,Wu S,Jiang S,Bao J,Wang B,Kong R,Zhang S,Zheng S,Cao X,Hong X

Fri Apr 15 00:00:00 EDT 2022

Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice.

Biological research

Chen Y,Zhou Y,Li XC,Ma X,Mi WL,Chu YX,Wang YQ,Mao-Ying QL

Thu Feb 03 00:00:00 EST 2022

CD16⁺ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition.

Cancer cell

Liu X,Lu Y,Huang J,Xing Y,Dai H,Zhu L,Li S,Feng J,Zhou B,Li J,Xia Q,Li J,Huang M,Gu Y,Su S

Mon Nov 14 00:00:00 EST 2022

Suppression of AGTR1 Induces Cellular Senescence in Hepatocellular Carcinoma Through Inactivating ERK Signaling.

Frontiers in bioengineering and biotechnology

Wang H,Cui Y,Gong H,Xu J,Huang S,Tang A

Tue Aug 02 00:00:00 EDT 2022

Ruxolitinib attenuates secondary injury after traumatic spinal cord injury.

Neural regeneration research

Qian ZY,Kong RY,Zhang S,Wang BY,Chang J,Cao J,Wu CQ,Huang ZY,Duan A,Li HJ,Yang L,Cao XJ

Thu Sep 01 00:00:00 EDT 2022

Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression.

Communications biology

Yang Y,Xiao Q,Yin J,Li C,Yu D,He Y,Yang Z,Wang G

Tue Apr 19 00:00:00 EDT 2022

Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding.

Plants (Basel, Switzerland)

Chen TY,Chen YL,Chiu WC,Yeh CL,Tung YT,Shirakawa H,Liao WT,Yang SC

Thu Feb 24 00:00:00 EST 2022

Elevated FOXA1 Expression Indicates Poor Prognosis in Liver Cancer due to Its Effects on Cell Proliferation and Metastasis.

Disease markers

Liu Z,Wang Y,Aizimuaji Z,Ma S,Xiao T

Tue Aug 16 00:00:00 EDT 2022

Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.

Biochemical and biophysical research communications

Fan R,Jiang H,Hu Y,Xu Y,Zhou Y,Chen G,Liu Y,Yao Y,Qin W,Chen W,Huang F,Chen X

Sun Dec 25 00:00:00 EST 2022

Combined Therapy of Low-Dose Angiotensin Receptor-Neprilysin Inhibitor and Sodium-Glucose Cotransporter-2 Inhibitor Prevents Doxorubicin-Induced Cardiac Dysfunction in Rodent Model with Minimal Adverse Effects.

Pharmaceutics

Kim D,Jang G,Hwang J,Wei X,Kim H,Son J,Rhee SJ,Yun KH,Oh SK,Oh CM,Park R

Mon Nov 28 00:00:00 EST 2022

Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1.

Frontiers in pharmacology

Cao Y,Yang L,Cheng H

Sat Jul 16 00:00:00 EDT 2022

Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome.

Viruses

Wei Z,Shimizu K,Sarii RS,Muthusinghe DS,Lokupathirage SMW,Nio-Kobayashi J,Yoshimatsu K

Thu Oct 13 00:00:00 EDT 2022

Radioprotective effects and mechanism of HL-003 on radiation-induced salivary gland damage in mice.

Scientific reports

Ren J,Huang R,Li Y,Chen R,Tian H,Liu C

Thu May 19 00:00:00 EDT 2022

Cell surface membrane lysosome-associated membrane glycoprotein 2 promotes cell adhesion via abundant N-glycans in choriocarcinoma.

Placenta

Nishino K,Nishiko Y,Shibata M,Oda Y,Watanabe E,Niimi K,Yamamoto E,Kajiyama H

Sat Jan 01 00:00:00 EST 2022

Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas.

Nature communications

Cheng Y,Shen Z,Gao Y,Chen F,Xu H,Mo Q,Chu X,Peng CL,McKenzie TT,Palacios BE,Hu J,Zhou H,Long J

Wed May 18 00:00:00 EDT 2022

Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors.

Cell death & disease

Fan Y,Zhang Y,Shi K,Cheng S,Pei D,Shu X

Sat Nov 26 00:00:00 EST 2022

Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.

Experimental biology and medicine (Maywood, N.J.)

Yi T,Chen H,Zhan J,Li Y,Long Z,Wu Z,Yang M,Peng T,Li H

Sat Jan 01 00:00:00 EST 2022

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Basic research in cardiology

Hulikova A,Park KC,Loonat AA,Gunadasa-Rohling M,Curtis MK,Chung YJ,Wilson A,Carr CA,Trafford AW,Fournier M,Moshnikova A,Andreev OA,Reshetnyak YK,Riley PR,Smart N,Milne TA,Crump NT,Swietach P

Thu Mar 31 00:00:00 EDT 2022

Paraoxonase 2 is an ER chaperone that regulates the epithelial Na⁺ channel.

American journal of physiology. Cell physiology

Shi S,Buck TM,Nickerson AJ,Brodsky JL,Kleyman TR

Sat Jan 01 00:00:00 EST 2022

Up-regulation of miR-335 and miR-674-3p in the rostral ventrolateral medulla contributes to stress-induced hypertension.

Journal of neurochemistry

Zhang S,Xing M,Chen G,Tong L,Zhang H,Du D

Wed Jun 01 00:00:00 EDT 2022

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.

Science advances

Watamura N,Sato K,Shiihashi G,Iwasaki A,Kamano N,Takahashi M,Sekiguchi M,Mihira N,Fujioka R,Nagata K,Hashimoto S,Saito T,Ohshima T,Saido TC,Sasaguri H

Fri Jun 10 00:00:00 EDT 2022

PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.

Arteriosclerosis, thrombosis, and vascular biology

Kant S,Tran KV,Kvandova M,Caliz AD,Yoo HJ,Learnard H,Dolan AC,Craige SM,Hall JD,Jiménez JM,St Hilaire C,Schulz E,Kröller-Schön S,Keaney JF

Sat Jan 01 00:00:00 EST 2022

LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.

Autophagy

Nabar NR,Heijjer CN,Shi CS,Hwang IY,Ganesan S,Karlsson MCI,Kehrl JH

Sat Jan 01 00:00:00 EST 2022

Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.

Nature communications

Chen X,Luo R,Zhang Y,Ye S,Zeng X,Liu J,Huang D,Liu Y,Liu Q,Luo ML,Song E

Tue Nov 22 00:00:00 EST 2022

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.

Nature communications

Zhou W,Wu WH,Si ZL,Liu HL,Wang H,Jiang H,Liu YF,Alolga RN,Chen C,Liu SJ,Bian XY,Shan JJ,Li J,Tan NH,Zhang ZH

Fri Oct 14 00:00:00 EDT 2022

Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.

Science translational medicine

Dixit D,Prager BC,Gimple RC,Miller TE,Wu Q,Yomtoubian S,Kidwell RL,Lv D,Zhao L,Qiu Z,Zhang G,Lee D,Park DE,Wechsler-Reya RJ,Wang X,Bao S,Rich JN

Wed Jan 05 00:00:00 EST 2022

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity.

The Journal of biological chemistry

Li Q,Zhong X,Yao W,Yu J,Wang C,Li Z,Lai S,Qu F,Fu X,Huang X,Zhang D,Liu Y,Li H

Fri Apr 01 00:00:00 EDT 2022

Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.

Oncogene

Hong S,Xie Y,Cheng Z,Li J,He W,Guo Z,Zhang Q,Peng S,He M,Yu S,Xu L,Liu R,Xu T,Zhang Y,Li Y,Wang J,Lv W,Yu J,Xiao H

Tue Nov 01 00:00:00 EDT 2022

Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/LncRNA-ROR.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Wang R,Li S,Chen P,Yue X,Wang S,Gu Y,Yuan Y

Thu Dec 01 00:00:00 EST 2022

Genome-Wide Analysis of Circular RNAs Reveals circCHRNG Regulates Sheep Myoblast Proliferation via miR-133/SRF and MEF2A Axis.

International journal of molecular sciences

Liu Y,Chen Q,Bao J,Pu Y,Han J,Zhao H,Ma Y,Zhao Q

Fri Dec 16 00:00:00 EST 2022

PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.

The Journal of experimental medicine

Cheng YW,Zhang ZB,Lan BD,Lin JR,Chen XH,Kong LR,Xu L,Ruan CC,Gao PJ

Mon Sep 06 00:00:00 EDT 2021

Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.

Neurobiology of disease

Jaumotte JD,Franks AL,Bargerstock EM,Kisanga EP,Menden HL,Ghersi A,Omar M,Wang L,Rudine A,Short KL,Silswal N,Cole TJ,Sampath V,Monaghan-Nichols AP,DeFranco DB

Sun Aug 01 00:00:00 EDT 2021

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Zhang N,Bewick B,Schultz J,Tiwari A,Krencik R,Zhang A,Adachi K,Xia G,Yun K,Sarkar P,Ashizawa T

Thu Jul 01 00:00:00 EDT 2021

The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer.

Cancer communications (London, England)

Wang JZ,Zhu W,Han J,Yang X,Zhou R,Lu HC,Yu H,Yuan WB,Li PC,Tao J,Lu Q,Wei JF,Yang H

Thu Jul 01 00:00:00 EDT 2021

TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation.

JCI insight

Xiao P,Li M,Zhou M,Zhao X,Wang C,Qiu J,Fang Q,Jiang H,Dong H,Zhou R

Wed Dec 08 00:00:00 EST 2021

Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways.

Translational cancer research

Hu Y,Jing J,Shi Y,Zhang P,Dong D,Wu Y,Dong X,Li E,Fan Y

Thu Jul 01 00:00:00 EDT 2021

A single amino acid substitution in PRKDC is a determinant of sensitivity to Adriamycin-induced renal injury in mouse.

Biochemical and biophysical research communications

Watanabe M,Takahashi Y,Hiura K,Nakano K,Okamura T,Sasaki H,Sasaki N

Fri Jun 04 00:00:00 EDT 2021

The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.

Neoplasia (New York, N.Y.)

Yi JS,Sias-Garcia O,Nasholm N,Hu X,Iniguez AB,Hall MD,Davis M,Guha R,Moreno-Smith M,Barbieri E,Duong K,Koach J,Qi J,Bradner JE,Stegmaier K,Weiss WA,Gustafson WC

Tue Jun 01 00:00:00 EDT 2021

Rice Husk Silica Liquid Protects Pancreatic β Cells from Streptozotocin-Induced Oxidative Damage.

Antioxidants (Basel, Switzerland)

Chen HY,Chiang YF,Wang KL,Huang TC,Ali M,Shieh TM,Chang HY,Hong YH,Hsia SM

Mon Jul 05 00:00:00 EDT 2021

HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production.

Experimental cell research

Wang J,Chen Y,Zeng Z,Feng R,Wang Q,Zhang Q,Sun K,Chen AF,Lu Y,Yu Y

Mon Nov 01 00:00:00 EDT 2021

Highly Conserved C-Terminal Region of Indian Hedgehog N-Fragment Contributes to Its Auto-Processing and Multimer Formation.

Biomolecules

Wang X,Liu H,Liu Y,Han G,Wang Y,Chen H,He L,Ma G

Tue May 25 00:00:00 EDT 2021

A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer.

Biochemical pharmacology

Liu X,Hu Q,Wang W,Ma H,Pu J,Cui J,Gong T,Wu Y,Lu W,Huang J

Tue Jun 01 00:00:00 EDT 2021

Hypusination of Eif5a regulates cytoplasmic TDP-43 aggregation and accumulation in a stress-induced cellular model.

Biochimica et biophysica acta. Molecular basis of disease

Smeltzer S,Quadri Z,Miller A,Zamudio F,Hunter J,Stewart NJF,Saji S,Lee DC,Chaput D,Selenica MB

Fri Jan 01 00:00:00 EST 2021

Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.

Brain research

Pawlik MJ,Obara-Michlewska M,Popek MP,Czarnecka AM,Czuczwar SJ,Łuszczki J,Kołodziej M,Acewicz A,Wierzba-Bobrowicz T,Albrecht J

Mon Feb 15 00:00:00 EST 2021

Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.

Journal of healthcare engineering

You Z,He L,Yan N

Mon Feb 21 00:00:00 EST 2022

Bifidobacterium infantis Maintains Genome Stability in Ulcerative Colitis via Regulating Anaphase-Promoting Complex Subunit 7.

Frontiers in microbiology

Han T,Hu X,Li K,Zhang D,Zhang Y,Li J

Sat Nov 20 00:00:00 EST 2021

Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.

Redox biology

Chen H,Qian Z,Zhang S,Tang J,Fang L,Jiang F,Ge D,Chang J,Cao J,Yang L,Cao X

Fri Jan 01 00:00:00 EST 2021

Mitochondrial activity regulates the differentiation of skin-derived mesenchymal stem cells into brown adipocytes to contribute to hypertension.

Stem cell research & therapy

Xi W,Chen W,Sun W,Li X,Suo Z,Jiang G,Gao P,Li Q

Wed Mar 10 00:00:00 EST 2021

Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.

EBioMedicine

Li F,Li J,Yu J,Pan T,Yu B,Sang Q,Dai W,Hou J,Yan C,Zang M,Zhu Z,Su L,Li YY,Liu B

Thu Jul 01 00:00:00 EDT 2021

Lipolytic gene DAGLA is targeted by miR-223 in chicken hepatocytes.

Gene

Wang X,Li Y,Qu L,Guo J,Dou T,Hu Y,Ma M,Wang K

Sat Jan 30 00:00:00 EST 2021

Carbon Monoxide Releasing Molecule-3 Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Carbon Monoxide Release.

Drug design, development and therapy

Chen H,Dai Y,Cui J,Yin X,Feng W,Lv M,Song H

Thu Nov 04 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Thu Dec 09 00:00:00 EST 2021

The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells.

Cells

Shamloul A,Steinemann G,Roos K,Liem CH,Bernd J,Braun T,Zakrzewicz A,Berkholz J

Mon Dec 13 00:00:00 EST 2021

Discovery of Potent Antiallergic Agents Based on an o-Aminopyridinyl Alkynyl Scaffold.

Journal of medicinal chemistry

Xie Z,Xiang C,Li X,Fan C,Chen T,Liu M,Ma Y,Bai F,Tang W,Hu Y

Thu Sep 23 00:00:00 EDT 2021

Effects of aging on the histology and biochemistry of rat tendon healing.

BMC musculoskeletal disorders

Lai F,Tang H,Wang J,Lu K,Bian X,Wang Y,Shi Y,Guo Y,He G,Zhou M,Zhang X,Zhou B,Zhang J,Chen W,Tang K

Mon Nov 15 00:00:00 EST 2021

miR-708 Negatively Regulates TNFα/IL-1β Signaling by Suppressing NF-κB and Arachidonic Acid Pathways.

Mediators of inflammation

Monteleone NJ,Lutz CS

Thu Nov 04 00:00:00 EDT 2021

Maternal vitamin A deficiency impairs cholinergic and nitrergic neurons, leading to gastrointestinal dysfunction in rat offspring via RARβ.

Life sciences

Tan M,Yang T,Liu H,Xiao L,Li C,Zhu J,Chen J,Li T

Fri Jan 01 00:00:00 EST 2021

TAZ maintains telomere length in TNBC cells by mediating Rad51C expression.

Breast cancer research : BCR

Yang L,Wang B,Jiao X,Zhou C,Chen S,Gao X,Sun W,Song S,Li J,Liu J,Wang Y,Liu P

Mon Sep 06 00:00:00 EDT 2021

Decreased Expression and Uncoupling of Endothelial Nitric Oxide Synthase in the Cerebral Cortex of Rats with Thioacetamide-Induced Acute Liver Failure.

International journal of molecular sciences

Milewski K,Czarnecka AM,Albrecht J,Zielińska M

Tue Jun 22 00:00:00 EDT 2021

Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.

Journal of medicinal chemistry

Davis RR,Li B,Yun SY,Chan A,Nareddy P,Gunawan S,Ayaz M,Lawrence HR,Reuther GW,Lawrence NJ,Schönbrunn E

Thu Feb 25 00:00:00 EST 2021

Citrate regulates extracellular matrix mineralization during osteoblast differentiation in vitro.

Journal of inorganic biochemistry

Wu X,Dai H,Yu S,Zhao Y,Long Y,Li W,Tu J

Fri Jan 01 00:00:00 EST 2021

Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.

Immunobiology

Heck AL,Mishra S,Prenzel T,Feulner L,Achhammer E,Särchen V,Blagg BSJ,Schneider-Brachert W,Schütze S,Fritsch J

Mon Mar 01 00:00:00 EST 2021

WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells.

Frontiers in cell and developmental biology

Li Y,Bhanja A,Upadhyaya A,Zhao X,Song W

Mon Feb 28 00:00:00 EST 2022

The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma.

Blood advances

Lipchick BC,Utley A,Han Z,Moparthy S,Yun DH,Bianchi-Smiraglia A,Wolff DW,Fink E,Liu L,Furdui CM,Lee J,Lee KP,Nikiforov MA

Tue Apr 13 00:00:00 EDT 2021

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis.

Human reproduction (Oxford, England)

Li Y,Zeng X,Lu D,Yin M,Shan M,Gao Y

Thu Mar 18 00:00:00 EDT 2021

GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.

Cell death & disease

Xia Z,Zhang X,Liu P,Zhang R,Huang Z,Li D,Xiao X,Wu M,Ning N,Zhang Q,Zhang J,Liu M,Jiao B,Ren R

Sat Jan 09 00:00:00 EST 2021

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.

Nature immunology

Huang D,Chen X,Zeng X,Lao L,Li J,Xing Y,Lu Y,Ouyang Q,Chen J,Yang L,Su F,Yao H,Liu Q,Su S,Song E

Thu Jul 01 00:00:00 EDT 2021

HIV reprograms host m⁶Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1.

Nature communications

Zhang Q,Kang Y,Wang S,Gonzalez GM,Li W,Hui H,Wang Y,Rana TM

Mon Sep 20 00:00:00 EDT 2021

SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes.

Frontiers in cell and developmental biology

Giordano I,Pirone L,Muratore V,Landaluze E,Pérez C,Lang V,Garde-Lapido E,Gonzalez-Lopez M,Barroso-Gomila O,Vertegaal ACO,Aransay AM,Rodriguez JA,Rodriguez MS,Sutherland JD,Barrio R

Sat Oct 09 00:00:00 EDT 2021

Pyrvinium pamoate inhibits cell proliferation through ROS-mediated AKT-dependent signaling pathway in colorectal cancer.

Medical oncology (Northwood, London, England)

Zheng W,Hu J,Lv Y,Bai B,Shan L,Chen K,Dai S,Zhu H

Mon Feb 08 00:00:00 EST 2021

Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.

Biochemical and biophysical research communications

Wu Y,Qi Y,Qiu Z,Chen W

Fri Dec 03 00:00:00 EST 2021

Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.

Frontiers in aging neuroscience

Tian Y,He M,Pan L,Yuan X,Xiong M,Meng L,Yao Z,Yu Z,Ye K,Zhang Z

Wed Nov 10 00:00:00 EST 2021

Characterizing the distributions of IDO-1 expressing macrophages/microglia in human and murine brains and evaluating the immunological and physiological roles of IDO-1 in RAW264.7/BV-2 cells.

PloS one

Ji R,Ma L,Chen X,Sun R,Zhang L,Saiyin H,Wei W

Thu Dec 23 00:00:00 EST 2021

TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.

Molecular biology reports

Ma M,Shi F,Zhai R,Wang H,Li K,Xu C,Yao W,Zhou F

Mon Mar 01 00:00:00 EST 2021

Hinokitiol Exhibits Antitumor Properties through Induction of ROS-Mediated Apoptosis and p53-Driven Cell-Cycle Arrest in Endometrial Cancer Cell Lines (Ishikawa, HEC-1A, KLE).

International journal of molecular sciences

Chen HY,Cheng WP,Chiang YF,Hong YH,Ali M,Huang TC,Wang KL,Shieh TM,Chang HY,Hsia SM

Sat Jul 31 00:00:00 EDT 2021

Effect of Metformin and Simvastatin in Inhibiting Proadipogenic Transcription Factors.

Current issues in molecular biology

Jakab J,Zjalić M,Mikšić Š,Tušek I,Ćosić V,Volarić N,Nakić D,Včev A,Miškić B

Thu Nov 25 00:00:00 EST 2021

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue.

Acta neuropathologica communications

Miller LVC,Mukadam AS,Durrant CS,Vaysburd MJ,Katsinelos T,Tuck BJ,Sanford S,Sheppard O,Knox C,Cheng S,James LC,Coleman MP,McEwan WA

Fri Mar 12 00:00:00 EST 2021

2-Hydroxypropyl-β-cyclodextrin Regulates the Epithelial to Mesenchymal Transition in Breast Cancer Cells by Modulating Cholesterol Homeostasis and Endoplasmic Reticulum Stress.

Metabolites

Zhao Y,He L,Wang T,Zhu L,Yan N

Mon Aug 23 00:00:00 EDT 2021

Divergence in chondrogenic potential between in vitro and in vivo of adipose- and synovial-stem cells from mouse and human.

Stem cell research & therapy

Chijimatsu R,Miwa S,Okamura G,Miyahara J,Tachibana N,Ishikura H,Higuchi J,Maenohara Y,Tsuji S,Sameshima S,Takagi K,Nakazato K,Kawaguchi K,Yamagami R,Inui H,Taketomi S,Tanaka S,Saito T

Thu Jul 15 00:00:00 EDT 2021

Samm50 Promotes Hypertrophy by Regulating Pink1-Dependent Mitophagy Signaling in Neonatal Cardiomyocytes.

Frontiers in cardiovascular medicine

Xu R,Kang L,Wei S,Yang C,Fu Y,Ding Z,Zou Y

Tue Oct 12 00:00:00 EDT 2021

Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules.

Frontiers in cardiovascular medicine

Messerschmidt VL,Chintapula U,Kuriakose AE,Laboy S,Truong TTD,Kydd LA,Jaworski J,Pan Z,Sadek H,Nguyen KT,Lee J

Mon Nov 15 00:00:00 EST 2021

HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity.

Cell reports

Chai Q,Li S,Collins MK,Li R,Ahmad I,Johnson SF,Frabutt DA,Yang Z,Shen X,Sun L,Hu J,Hultquist JF,Peterlin BM,Zheng YH

Tue Aug 10 00:00:00 EDT 2021

Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.

Toxicology letters

Jian B,Pang J,Xiong H,Zhang W,Zhan T,Su Z,Lin H,Zhang H,He W,Zheng Y

Sun Oct 10 00:00:00 EDT 2021

Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors.

Small methods

Zhang Y,Wang S,Wu Y,Hou W,Yuan L,Shen C,Wang J,Ye J,Zheng Q,Ma J,Xu J,Wei M,Li Z,Nian S,Xiong H,Zhang L,Shi Y,Fu B,Cao J,Yang C,Li Z,Yang T,Liu L,Yu H,Hu J,Ge S,Chen Y,Zhang T,Zhang J,Cheng T,Yuan Q,Xia N

Mon Feb 15 00:00:00 EST 2021

WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.

Nature communications

Wu M,Xia X,Hu J,Fowlkes NW,Li S

Wed Jun 09 00:00:00 EDT 2021

Porcine ZBED6 regulates growth of skeletal muscle and internal organs via multiple targets.

PLoS genetics

Wang D,Pan D,Xie B,Wang S,Xing X,Liu X,Ma Y,Andersson L,Wu J,Jiang L

Fri Oct 01 00:00:00 EDT 2021

Development and Validation of a Ferroptosis-Related Gene Signature for Overall Survival Prediction in Lung Adenocarcinoma.

Frontiers in cell and developmental biology

Tian Q,Zhou Y,Zhu L,Gao H,Yang J

Tue Jul 27 00:00:00 EDT 2021

11βHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.

Journal of the Endocrine Society

Ali Y,Kuppusamy M,Velarde-Miranda C,Gomez-Sanchez CM,Plonczynski M,Gomez-Sanchez CE,Gomez-Sanchez EP

Mon Nov 01 00:00:00 EDT 2021

Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats.

Frontiers in neuroscience

Liu H,Tan M,Cheng B,Wang S,Xiao L,Zhu J,Wu Q,Lai X,Zhang Q,Chen J,Li T

Sat Apr 23 00:00:00 EDT 2022

Indoleamine-2,3-Dioxygenase Activates Wnt/β-Catenin Inducing Kidney Fibrosis after Acute Kidney Injury.

Gerontology

Pan B,Zhang H,Hong Y,Ma M,Wan X,Cao C

Tue Nov 16 00:00:00 EST 2021

DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.

Neurochemical research

Qi Z,Zhang Y,Yao K,Zhang M,Xu Y,Zhang J,Bai X,Zu H

Thu Jul 01 00:00:00 EDT 2021

Transcriptomic analysis of tumor tissues and organoids reveals the crucial genes regulating the proliferation of lung adenocarcinoma.

Journal of translational medicine

Ma X,Yang S,Jiang H,Wang Y,Xiang Z

Thu Aug 26 00:00:00 EDT 2021

Development and Validation of High-Content Analysis for Screening HDAC6-Selective Inhibitors.

SLAS discovery : advancing life sciences R & D

Nong Y,Hou Y,Pu Y,Li S,Lan Y

Tue Jun 01 00:00:00 EDT 2021

An Ultra-Stable, Oxygen-Supply Nanoprobe Emitting in Near-Infrared-II Window to Guide and Enhance Radiotherapy by Promoting Anti-Tumor Immunity.

Advanced healthcare materials

Wang M,Li H,Huang B,Chen S,Cui R,Sun ZJ,Zhang M,Sun T

Tue Jun 01 00:00:00 EDT 2021

Downregulation of Prolactin-Induced Protein Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells.

Medical science monitor : international medical journal of experimental and clinical research

Li X,Zhang Y,Jia L,Xing Y,Zhao B,Sui L,Liu D,Xu X

Mon Jun 07 00:00:00 EDT 2021

JNK Signaling Pathway Mediates Fluoride-Induced Upregulation of CK1α during Enamel Formation.

Caries research

Yang Z,Shi G,Guo J,Zhou Y,Jia J

Thu Jun 24 00:00:00 EDT 2021

A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu S,Lu Y,Su A,Chen J,Li J,Zhou B,Liu X,Xia Q,Li Y,Li J,Huang M,Ye Y,Zhao Q,Jiang S,Yan X,Wang X,Di C,Pan J,Su S

Fri Oct 01 00:00:00 EDT 2021

Defining the protein and lipid constituents of tubular recycling endosomes.

The Journal of biological chemistry

Farmer T,Xie S,Naslavsky N,Stöckli J,James DE,Caplan S

Wed Aug 18 00:00:00 EDT 2021

The IRENA lncRNA converts chemotherapy-polarized tumor-suppressing macrophages to tumor-promoting phenotypes in breast cancer.

Nature cancer

Liu J,Lao L,Chen J,Li J,Zeng W,Zhu X,Li J,Chen X,Yang L,Xing Y,Chen F,Huang D,Zhang X,Wei W,Gong C,Huang S,Yu Z,Li Z,Yang L,Liu J,Liu X,Zheng Q,Meng X,Liang J,Sun L,Zeng M,Li M,Liu Q,Su S,Song E

Thu Apr 01 00:00:00 EDT 2021

Characteristics of the Gut Microbiome and IL-13/TGF-β1 Mediated Fibrosis in Post-Kasai Cholangitis of Biliary Atresia.

Frontiers in pediatrics

Meng L,Liu J,Wang J,Du M,Zhang S,Huang Y,Shen Z,Dong R,Chen G,Zheng S

Sat Dec 04 00:00:00 EST 2021

Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors.

Journal of ovarian research

Crean-Tate KK,Braley C,Dey G,Esakov E,Saygin C,Trestan A,Silver DJ,Turaga SM,Connor EV,DeBernardo R,Michener CM,Rose PG,Lathia J,Reizes O

Thu Apr 22 00:00:00 EDT 2021

Analyses of key mRNAs and lncRNAs for different osteo-differentiation potentials of periodontal ligament stem cell and gingival mesenchymal stem cell.

Journal of cellular and molecular medicine

Jia L,Zhang Y,Li D,Zhang W,Zhang D,Xu X

Mon May 24 00:00:00 EDT 2021

Disrupting RhoA activity by blocking Arhgef3 expression mitigates microglia-induced neuroinflammation post spinal cord contusion.

Journal of neuroimmunology

Liao L,Qian ZY,Li XY,Yang DS,Lei BJ,Li HJ,Hong X

Fri Oct 15 00:00:00 EDT 2021

EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function.

Cell death & disease

Bahl S,Ling H,Acharige NPN,Santos-Barriopedro I,Pflum MKH,Seto E

Tue May 11 00:00:00 EDT 2021

Perturbation of astroglial Slc38 glutamine transporters by NH₄⁺ contributes to neurophysiologic manifestations in acute liver failure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Hamdani EH,Popek M,Frontczak-Baniewicz M,Utheim TP,Albrecht J,Zielińska M,Chaudhry FA

Thu Jul 01 00:00:00 EDT 2021

SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer.

Nature communications

Wang X,Zhang H,Sapio R,Yang J,Wong J,Zhang X,Guo JY,Pine S,Van Remmen H,Li H,White E,Liu C,Kiledjian M,Pestov DG,Steven Zheng XF

Thu Apr 15 00:00:00 EDT 2021

Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Bioengineered

Zhao X,Wang J,Tang L,Li P,Ru J,Bai Y

Wed Dec 01 00:00:00 EST 2021

Fzd7/Wnt7b signaling contributes to stemness and chemoresistance in pancreatic cancer.

Cancer medicine

Zhang Z,Xu Y,Zhao C

Sat May 01 00:00:00 EDT 2021

Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation.

Journal of ethnopharmacology

Qin W,Tong X,Liang R,Tang K,Wu X,Jia Y,Tan N

Mon May 10 00:00:00 EDT 2021

Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees.

Insect biochemistry and molecular biology

Flores ME,McNamara-Bordewick NK,Lovinger NL,Snow JW

Wed Dec 01 00:00:00 EST 2021

Nicotinic Acetylcholine Receptor Subunit α7 Mediates Cigarette Smoke-Induced PD-L1 Expression in Human Bronchial Epithelial Cells.

Cancers

Kwok HH,Gao B,Chan KH,Ip MS,Minna JD,Lam DC

Mon Oct 25 00:00:00 EDT 2021

IKKε knockout alleviates angiotensin II-induced apoptosis and excessive autophagy in vascular smooth muscle cells by regulating the ERK1/2 pathway.

Experimental and therapeutic medicine

Chen G,Xu Y,Yao Y,Cao Y,Liu Y,Chai H,Chen W,Chen X

Fri Oct 01 00:00:00 EDT 2021

SIX1 Activation Is Involved in Cell Proliferation, Migration, and Anti-inflammation of Acute Ischemia/Reperfusion Injury in Mice.

Frontiers in molecular biosciences

Jin Y,Zhang M,Li M,Zhang H,Zhao L,Qian C,Li S,Zhang H,Gao M,Pan B,Li R,Wan X,Cao C

Tue Sep 14 00:00:00 EDT 2021

Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury.

Cell death discovery

Jiang S,Wu Y,Wu S,Ye S,Kong R,Chang J,Xia M,Bao J,Peng X,Hong X,Qian Z,Li H

Sat May 08 00:00:00 EDT 2021

m⁶ A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.

The EMBO journal

Wang L,Hui H,Agrawal K,Kang Y,Li N,Tang R,Yuan J,Rana TM

Thu Oct 15 00:00:00 EDT 2020

The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis.

Oncogene

Zhou Q,Wu X,Wang X,Yu Z,Pan T,Li Z,Chang X,Jin Z,Li J,Zhu Z,Liu B,Su L

Sat Feb 01 00:00:00 EST 2020

Knockout of mouse receptor accessory protein 6 leads to sperm function and morphology defects†.

Biology of reproduction

Devlin DJ,Agrawal Zaneveld S,Nozawa K,Han X,Moye AR,Liang Q,Harnish JM,Matzuk MM,Chen R

Tue May 26 00:00:00 EDT 2020

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Cell reports

Davenne T,Klintman J,Sharma S,Rigby RE,Blest HTW,Cursi C,Bridgeman A,Dadonaite B,De Keersmaecker K,Hillmen P,Chabes A,Schuh A,Rehwinkel J

Tue May 12 00:00:00 EDT 2020

Glibenclamide ameliorates transplant-induced arteriosclerosis and inhibits macrophage migration and MCP-1 expression.

Life sciences

Zou Y,Zhou C,Xu H,Yu J,Ye P,Zhang H,Chen S,Zhao J,Le S,Cui J,Jiang L,Wu J,Xia J

Wed Jan 15 00:00:00 EST 2020

Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis.

Frontiers in pharmacology

Xie Z,Lu H,Yang S,Zeng Y,Li W,Wang L,Luo G,Fang F,Zeng T,Cheng W

Tue Dec 29 00:00:00 EST 2020

LncRNA DILA1 inhibits Cyclin D1 degradation and contributes to tamoxifen resistance in breast cancer.

Nature communications

Shi Q,Li Y,Li S,Jin L,Lai H,Wu Y,Cai Z,Zhu M,Li Q,Li Y,Wang J,Liu Y,Wu Z,Song E,Liu Q

Mon Nov 02 00:00:00 EST 2020

Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria.

Journal of neurochemistry

Ren YZ,Zhang BZ,Zhao XJ,Zhang ZY

Tue Sep 01 00:00:00 EDT 2020

Magnesium Calcium Phosphate Cement Incorporating Citrate for Vascularized Bone Regeneration.

ACS biomaterials science & engineering

Wu X,Dai H,Yu S,Zhao Y,Long Y,Li W,Tu J

Mon Nov 09 00:00:00 EST 2020

Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase.

Cell chemical biology

Wu X,Spence JS,Das T,Yuan X,Chen C,Zhang Y,Li Y,Sun Y,Chandran K,Hang HC,Peng T

Thu May 21 00:00:00 EDT 2020

Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRα Expression in Hepatocytes and Macrophages.

Nutrients

Wang T,Zhao Y,You Z,Li X,Xiong M,Li H,Yan N

Sun Oct 11 00:00:00 EDT 2020

Enhancer-Driven lncRNA BDNF-AS Induces Endocrine Resistance and Malignant Progression of Breast Cancer through the RNH1/TRIM21/mTOR Cascade.

Cell reports

Lin X,Dinglin X,Cao S,Zheng S,Wu C,Chen W,Li Q,Hu Q,Zheng F,Wu Z,Lin DC,Yao Y,Xu X,Xie Z,Liu Q,Yao H,Hu H

Tue Jun 09 00:00:00 EDT 2020

Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.

Oncology letters

Wang Z,Xiang Z,Zhu T,Chen J,Zhong MZ,Huang J,Wang KS,Li L,Sun LQ,Zhou WB

Wed Jan 01 00:00:00 EST 2020

CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells.

Cell communication and signaling : CCS

Li H,Che J,Jiang M,Cui M,Feng G,Dong J,Zhang S,Lu L,Liu W,Fan S

Thu Sep 17 00:00:00 EDT 2020

Long non-coding RNA PHACTR2-AS1 promotes tongue squamous cell carcinoma metastasis by regulating Snail.

Journal of biochemistry

Yuan F,Miao Z,Chen W,Wu F,Wei C,Yong J,Xiao C

Sat Dec 26 00:00:00 EST 2020

RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.

Scientific reports

Chen DB,Xie XW,Zhao YJ,Wang XY,Liao WJ,Chen P,Deng KJ,Fei R,Qin WY,Wang JH,Wu X,Shao QX,Wei L,Chen HS

Thu Sep 03 00:00:00 EDT 2020

Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α-KV1.5 channel pathway.

Chemico-biological interactions

He Y,Fang X,Shi J,Li X,Xie M,Liu X

Sat Feb 01 00:00:00 EST 2020

Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.

Molecular medicine reports

Wu Y,Zhao Y,He X,He Z,Wang T,Wan L,Chen L,Yan N

Wed Jan 01 00:00:00 EST 2020

STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease.

Laboratory investigation; a journal of technical methods and pathology

Wang X,Rao H,Zhao J,Wee A,Li X,Fei R,Huang R,Wu C,Liu F,Wei L

Wed Apr 01 00:00:00 EDT 2020

Electric field down-regulates CD9 to promote keratinocytes migration through AMPK pathway.

International journal of medical sciences

Ji R,Teng M,Zhang Z,Wang W,Zhang Q,Lv Y,Zhang J,Jiang X

Wed Feb 24 00:00:00 EST 2021

Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.

The Journal of biological chemistry

Shi S,Montalbetti N,Wang X,Rush BM,Marciszyn AL,Baty CJ,Tan RJ,Carattino MD,Kleyman TR

Fri Apr 10 00:00:00 EDT 2020

Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.

Molecular cell

Li L,Zhu S,Shu W,Guo Y,Guan Y,Zeng J,Wang H,Han L,Zhang J,Liu X,Li C,Hou X,Gao M,Ge J,Ren C,Zhang H,Schedl T,Guo X,Chen M,Wang Q

Thu Nov 05 00:00:00 EST 2020

miR-3 Encoded by Hepatitis B Virus Downregulates PTEN Protein Expression and Promotes Cell Proliferation.

Journal of hepatocellular carcinoma

Tang J,Xiao X,Jiang Y,Tian Y,Peng Z,Yang M,Xu Z,Gong G

Mon Apr 18 00:00:00 EDT 2022

Hydroxysafflor yellow A induces autophagy in human liver cancer cells by regulating Beclin 1 and ERK expression.

Experimental and therapeutic medicine

Chen Z,Liu L,Liu Y,Wang S,Zhang S,Dong R,Xu M,Ma Y,Wang J,Zhang Q,Wei P

Wed Apr 01 00:00:00 EDT 2020

Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.

Journal of Cancer

Fan Y,Ma K,Jing J,Wang C,Hu Y,Shi Y,Li E,Geng Q

Thu Oct 01 00:00:00 EDT 2020

Inhibition of USP15 Prevent Glutamate-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway in HT22 Cells.

Cellular and molecular neurobiology

Chen X,Bao G,Liu F

Sat Aug 01 00:00:00 EDT 2020

High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.

Aging

Jin CY,Du L,Nuerlan AH,Wang XL,Yang YW,Guo R

Sat Dec 19 00:00:00 EST 2020

HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.

Cell proliferation

Lu L,Li H,Wu X,Rao J,Zhou J,Fan S,Shen Q

Sun Mar 01 00:00:00 EST 2020

Localization of ZIP14 and ZIP8 in HIBCPP Cells.

Brain sciences

Morgan SE,Schroten H,Ishikawa H,Zhao N

Sat Aug 08 00:00:00 EDT 2020

Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy.

Nutrients

Shirakawa T,Miyawaki A,Matsubara T,Okumura N,Okamoto H,Nakai N,Rojasawasthien T,Morikawa K,Inoue A,Goto A,Washio A,Tsujisawa T,Kawamoto T,Kokabu S

Sun Oct 11 00:00:00 EDT 2020

Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles.

Cancers

Taha EA,Sogawa C,Okusha Y,Kawai H,Oo MW,Elseoudi A,Lu Y,Nagatsuka H,Kubota S,Satoh A,Okamoto K,Eguchi T

Sat May 16 00:00:00 EDT 2020

LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model.

International journal of ophthalmology

Song S,Cheng J,Yu BJ,Zhou L,Xu HF,Yang LL

Mon Sep 28 00:00:00 EDT 2020

Downregulation of GPR183 on infection restricts the early infection and intracellular replication of mycobacterium tuberculosis in macrophage.

Microbial pathogenesis

Tang J,Shi Y,Zhan L,Qin C

Sat Aug 01 00:00:00 EDT 2020

Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling.

The journal of pain

Cui WQ,Chu YX,Xu F,Chen T,Gao L,Feng Y,Hu XM,Yang W,Du LX,Zhang WW,Mao-Ying QL,Mi WL,Wang YQ

Wed Jun 23 00:00:00 EDT 2021

Physiology and Morphological Correlates of Excitatory Transmission are Preserved in Glutamine Transporter SN1-Depleted Mouse Frontal Cortex.

Neuroscience

Popek M,Bobula B,Sowa J,Hess G,Frontczak-Baniewicz M,Albrecht J,Zielińska M

Thu Oct 15 00:00:00 EDT 2020

Protocol for Site-Specific Photo-Crosslinking Proteomics to Identify Protein-Protein Interactions in Mammalian Cells.

STAR protocols

Chen C,Peng T

Fri Dec 18 00:00:00 EST 2020

Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.

Frontiers in oncology

Liu D,Song Z,Wang X,Ouyang L

Mon Sep 05 00:00:00 EDT 2022

HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV.

Molecular & cellular proteomics : MCP

Hock DH,Reljic B,Ang CS,Muellner-Wong L,Mountford HS,Compton AG,Ryan MT,Thorburn DR,Stroud DA

Wed Jul 01 00:00:00 EDT 2020

Suppressor of Ty 16 promotes lung cancer malignancy and is negatively regulated by miR-1227-5p.

Cancer science

Yang L,Wang X,Jiao X,Tian B,Zhang M,Zhou C,Wang R,Chen H,Wang B,Li J,Liu J,Zhang G,Liu P

Sun Nov 01 00:00:00 EDT 2020

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model.

Frontiers in immunology

Gu T,Zhao S,Jin G,Song M,Zhi Y,Zhao R,Ma F,Zheng Y,Wang K,Liu H,Xin M,Han W,Li X,Dong CD,Liu K,Dong Z

Thu Feb 18 00:00:00 EST 2021

The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies.

Cancer discovery

Prager BC,Vasudevan HN,Dixit D,Bernatchez JA,Wu Q,Wallace LC,Bhargava S,Lee D,King BH,Morton AR,Gimple RC,Pekmezci M,Zhu Z,Siqueira-Neto JL,Wang X,Xie Q,Chen C,Barnett GH,Vogelbaum MA,Mack SC,Chavez L,Perry A,Raleigh DR,Rich JN

Sun Nov 01 00:00:00 EDT 2020

Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model.

Arthritis research & therapy

Hamamoto Y,Ouhara K,Munenaga S,Shoji M,Ozawa T,Hisatsune J,Kado I,Kajiya M,Matsuda S,Kawai T,Mizuno N,Fujita T,Hirata S,Tanimoto K,Nakayama K,Kishi H,Sugiyama E,Kurihara H

Mon Oct 19 00:00:00 EDT 2020

Non-canonical Fzd7 signaling contributes to breast cancer mesenchymal-like stemness involving Col6a1.

Cell communication and signaling : CCS

Yin P,Bai Y,Wang Z,Sun Y,Gao J,Na L,Zhang Z,Wang W,Zhao C

Mon Sep 07 00:00:00 EDT 2020

miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.

Oncotarget

Monteleone NJ,Lutz CS

Tue Jun 30 00:00:00 EDT 2020

FAM122A Inhibits Erythroid Differentiation through GATA1.

Stem cell reports

Chen J,Zhou Q,Liu MH,Yang YS,Wang YQ,Huang Y,Chen GQ

Tue Sep 08 00:00:00 EDT 2020

PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.

Diabetes

Liu L,Fan L,Chan M,Kraakman MJ,Yang J,Fan Y,Aaron N,Wan Q,Carrillo-Sepulveda MA,Tall AR,Tabas I,Accili D,Qiang L

Sat Aug 01 00:00:00 EDT 2020

4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.

European journal of pharmacology

Tian F,Wang Z,He J,Zhang Z,Tan N

Wed Apr 15 00:00:00 EDT 2020

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.

Nature

Yang L,Liu Q,Zhang X,Liu X,Zhou B,Chen J,Huang D,Li J,Li H,Chen F,Liu J,Xing Y,Chen X,Su S,Song E

Wed Jul 01 00:00:00 EDT 2020

Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 signaling pathway.

Experimental cell research

Jia L,Xiong Y,Zhang W,Ma X,Xu X

Wed Jan 15 00:00:00 EST 2020

miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells.

Oncotarget

Monteleone NJ,Lutz CS

Tue Dec 22 00:00:00 EST 2020

Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes.

Cell calcium

Skowrońska K,Kozłowska H,Albrecht J

Tue Dec 01 00:00:00 EST 2020

Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.

CNS neuroscience & therapeutics

Gao M,Lu W,Shu Y,Yang Z,Sun S,Xu J,Gan S,Zhu S,Qiu G,Zhuo F,Xu S,Wang Y,Chen J,Wu X,Huang J

Tue Dec 01 00:00:00 EST 2020

High salt diet may promote progression of breast tumor through eliciting immune response.

International immunopharmacology

Chen J,Liu X,Huang H,Zhang F,Lu Y,Hu H

Thu Oct 01 00:00:00 EDT 2020

AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.

Journal of immunology (Baltimore, Md. : 1950)

Zhao W,Shi CS,Harrison K,Hwang IY,Nabar NR,Wang M,Kehrl JH

Thu Oct 15 00:00:00 EDT 2020

Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing α-synuclein aggregation and neuroinflammation.

European journal of pharmacology

Yu T,Wan F,Liu C,Zhang X,Liu Z,Zhang J,Xiong J,Wang T,Zhang Z

Sat Dec 05 00:00:00 EST 2020

Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 homology domain protein 1 (EHD1)-mediated fission machinery.

The Journal of biological chemistry

Dhawan K,Naslavsky N,Caplan S

Fri Mar 20 00:00:00 EDT 2020

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.

Cancers

Okusha Y,Eguchi T,Tran MT,Sogawa C,Yoshida K,Itagaki M,Taha EA,Ono K,Aoyama E,Okamura H,Kozaki KI,Calderwood SK,Takigawa M,Okamoto K

Sat Apr 04 00:00:00 EDT 2020

Eliminating senescent chondrogenic progenitor cells enhances chondrogenesis under intermittent hydrostatic pressure for the treatment of OA.

Stem cell research & therapy

Dai H,Chen R,Gui C,Tao T,Ge Y,Zhao X,Qin R,Yao W,Gu S,Jiang Y,Gui J

Mon May 25 00:00:00 EDT 2020

Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats.

Frontiers in pharmacology

Wang F,Li R,Tu P,Chen J,Zeng K,Jiang Y

Wed Apr 13 00:00:00 EDT 2022

EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation.

BMC molecular and cell biology

Zhang Y,Yang C,Ge S,Wang L,Zhang J,Yang P

Thu Apr 16 00:00:00 EDT 2020

TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p.

Molecular medicine reports

Li S,Yin Y,Yao L,Lin Z,Sun S,Zhang J,Li X

Sat Aug 01 00:00:00 EDT 2020

Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway.

Iranian journal of basic medical sciences

Xiong Y,Zhao B,Zhang W,Jia L,Zhang Y,Xu X

Wed Jul 01 00:00:00 EDT 2020

Oral Administration of Geranylgeraniol Rescues Denervation-induced Muscle Atrophy via Suppression of Atrogin-1.

In vivo (Athens, Greece)

Miyawaki A,Rojasawasthien T,Hitomi S,Aoki Y,Urata M,Inoue A,Matsubara T,Morikawa K,Habu M,Tominaga K,Kokabu S

Fri Jun 18 00:00:00 EDT 2021

Adenosine A_2A receptor activation prevents DOCA-salt induced hypertensive cardiac remodeling via iBAT.

Biochemical and biophysical research communications

Zhou YP,Ruan CC,Kong LR,Gao PJ

Wed Feb 19 00:00:00 EST 2020

Intravaginal Administration of Human Type III Collagen-Derived Biomaterial with High Cell-Adhesion Activity to Treat Vaginal Atrophy in Rats.

ACS biomaterials science & engineering

You S,Liu S,Dong X,Li H,Zhu Y,Hu L

Mon Apr 13 00:00:00 EDT 2020

The beneficial effect of oyster peptides and oyster powder on cyclophosphamide-induced reproductive impairment in male rats: A comparative study.

Journal of food biochemistry

Li M,Zhou M,Wei Y,Jia F,Yan Y,Zhang R,Cai M,Gu R

Sun Nov 01 00:00:00 EDT 2020

Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.

Acta pharmacologica Sinica

Zhang ZH,He JQ,Zhao YY,Chen HC,Tan NH

Sun Mar 01 00:00:00 EST 2020

PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells.

The Journal of biological chemistry

Huang Z,Liu M,Li D,Tan Y,Zhang R,Xia Z,Wang P,Jiao B,Liu P,Ren R

Fri Dec 25 00:00:00 EST 2020

Exon 9-deleted CETP inhibits full length-CETP synthesis and promotes cellular triglyceride storage.

Journal of lipid research

Izem L,Liu Y,Morton RE

Sun Mar 01 00:00:00 EST 2020

Tissue-Resident Macrophages Promote Renal Cystic Disease.

Journal of the American Society of Nephrology : JASN

Zimmerman KA,Song CJ,Li Z,Lever JM,Crossman DK,Rains A,Aloria EJ,Gonzalez NM,Bassler JR,Zhou J,Crowley MR,Revell DZ,Yan Z,Shan D,Benveniste EN,George JF,Mrug M,Yoder BK

Tue Oct 01 00:00:00 EDT 2019

Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wang Y,Chen J,Yang L,Li J,Wu W,Huang M,Lin L,Su S

Fri Mar 15 00:00:00 EDT 2019

Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wang Y,Chen J,Yang L,Li J,Wu W,Huang M,Lin L,Su S

Fri Mar 15 00:00:00 EDT 2019

Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.

Molecular cancer research : MCR

Mattoo AR,Joun A,Jessup JM

Tue Jan 01 00:00:00 EST 2019

Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition.

Molecular cancer research : MCR

Mattoo AR,Joun A,Jessup JM

Tue Jan 01 00:00:00 EST 2019

Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.

International journal of oncology

Wei DM,Jiang MT,Lin P,Yang H,Dang YW,Yu Q,Liao DY,Luo DZ,Chen G

Fri Feb 01 00:00:00 EST 2019

Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially‑expressed circRNAs, lncRNAs, miRNAs and mRNAs.

International journal of oncology

Wei DM,Jiang MT,Lin P,Yang H,Dang YW,Yu Q,Liao DY,Luo DZ,Chen G

Fri Feb 01 00:00:00 EST 2019

Spinal Serotonin 1A Receptor Contributes to the Analgesia of Acupoint Catgut Embedding by Inhibiting Phosphorylation of the N-Methyl-d-Aspartate Receptor GluN1 Subunit in Complete Freund's Adjuvant-Induced Inflammatory Pain in Rats.

The journal of pain

Cui WQ,Sun WS,Xu F,Hu XM,Yang W,Zhou Y,Du LX,Zhang WW,Mao-Ying QL,Mi WL,Chu YX,Wang YQ

Tue Jan 01 00:00:00 EST 2019

The journal of pain

Cui WQ,Sun WS,Xu F,Hu XM,Yang W,Zhou Y,Du LX,Zhang WW,Mao-Ying QL,Mi WL,Chu YX,Wang YQ

Tue Jan 01 00:00:00 EST 2019

Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.

International journal of molecular medicine

Ji Y,Zhang P,Xing Y,Jia L,Zhang Y,Jia T,Wu X,Zhao B,Xu X

Tue Jan 01 00:00:00 EST 2019

Effect of 1α, 25-dihydroxyvitamin D3 on the osteogenic differentiation of human periodontal ligament stem cells and the underlying regulatory mechanism.

International journal of molecular medicine

Ji Y,Zhang P,Xing Y,Jia L,Zhang Y,Jia T,Wu X,Zhao B,Xu X

Tue Jan 01 00:00:00 EST 2019

MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.

Journal of cellular and molecular medicine

Qu W,Wen X,Su K,Gou W

Fri Feb 01 00:00:00 EST 2019

MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression.

Journal of cellular and molecular medicine

Qu W,Wen X,Su K,Gou W

Fri Feb 01 00:00:00 EST 2019

Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.

Cancer biology & therapy

Fan Y,Li M,Ma K,Hu Y,Jing J,Shi Y,Li E,Dong D

Mon Jul 06 00:00:00 EDT 2020

Cancer biology & therapy

Fan Y,Li M,Ma K,Hu Y,Jing J,Shi Y,Li E,Dong D

Mon Jul 06 00:00:00 EDT 2020

Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.

Biology of reproduction

He Y,Lin Y,Zhu Y,Ping P,Wang G,Sun F

Fri Feb 01 00:00:00 EST 2019

Murine PAIP1 stimulates translation of spermiogenic mRNAs stored by YBX2 via its interaction with YBX2†.

Biology of reproduction

He Y,Lin Y,Zhu Y,Ping P,Wang G,Sun F

Fri Feb 01 00:00:00 EST 2019

Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.

Neurotoxicity research

Skowrońska K,Obara-Michlewska M,Czarnecka A,Dąbrowska K,Zielińska M,Albrecht J

Tue Jan 01 00:00:00 EST 2019

Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.

Neurotoxicity research

Skowrońska K,Obara-Michlewska M,Czarnecka A,Dąbrowska K,Zielińska M,Albrecht J

Tue Jan 01 00:00:00 EST 2019

PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.

Biochemical and biophysical research communications

Lim V,Zhu H,Diao S,Hu L,Hu J

Tue Jan 08 00:00:00 EST 2019

PKP3 interactions with MAPK-JNK-ERK1/2-mTOR pathway regulates autophagy and invasion in ovarian cancer.

Biochemical and biophysical research communications

Lim V,Zhu H,Diao S,Hu L,Hu J

Tue Jan 08 00:00:00 EST 2019

Mutations in topoisomerase IIβ result in a B cell immunodeficiency.

Nature communications

Broderick L,Yost S,Li D,McGeough MD,Booshehri LM,Guaderrama M,Brydges SD,Kucharova K,Patel NC,Harr M,Hakonarson H,Zackai E,Cowell IG,Austin CA,Hügle B,Gebauer C,Zhang J,Xu X,Wang J,Croker BA,Frazer KA,Putnam CD,Hoffman HM

Tue Aug 13 00:00:00 EDT 2019

BP‑1‑102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways.

Molecular medicine reports

Jiang X,Tang J,Wu M,Chen S,Xu Z,Wang H,Wang H,Yu X,Li Z,Teng L

Mon Apr 01 00:00:00 EDT 2019

Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway.

Cancers

Majewska E,Márquez J,Albrecht J,Szeliga M

Sat Jan 19 00:00:00 EST 2019

X-linked inhibitor of apoptosis protein accelerates migration by inducing epithelial-mesenchymal transition through TGF-β signaling pathway in esophageal cancer cells.

Cell & bioscience

Jin Y,Lu X,Wang M,Zhao X,Xue L

Sun Apr 10 00:00:00 EDT 2022

Regulation of the Metal Transporters ZIP14 and ZnT10 by Manganese Intake in Mice.

Nutrients

Felber DM,Wu Y,Zhao N

Wed Sep 04 00:00:00 EDT 2019

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane.

Molecular biology of the cell

Farmer T,O'Neill KL,Naslavsky N,Luo X,Caplan S

Wed May 01 00:00:00 EDT 2019

Analyses of epithelial Na⁺ channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.

The Journal of biological chemistry

Wang X,Chen J,Shi S,Sheng S,Kleyman TR

Fri Nov 08 00:00:00 EST 2019

The role of ZBTB38 in promoting migration and invasive growth of bladder cancer cells.

Oncology reports

Jing J,Liu J,Wang Y,Zhang M,Yang L,Shi F,Liu P,She J

Fri Mar 01 00:00:00 EST 2019

miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.

Aging

Xu X,Chen X,Xu M,Liu X,Pan B,Qin J,Xu T,Zeng K,Pan Y,He B,Sun H,Sun L,Wang S

Sun Sep 22 00:00:00 EDT 2019

Suhuang Antitussive Capsules-Ameliorative Effects on LPS-Induced Sputum Obstruction in Mice Through Promoting HGF Secretion.

Frontiers in pharmacology

Tong X,Liang R,Jia Y,Qin W,Guo C,Wu X,Wang Z,Chen D,Tan N

Wed Sep 30 00:00:00 EDT 2020

Palmitoylation is required for TNF-R1 signaling.

Cell communication and signaling : CCS

Zingler P,Särchen V,Glatter T,Caning L,Saggau C,Kathayat RS,Dickinson BC,Adam D,Schneider-Brachert W,Schütze S,Fritsch J

Mon Aug 05 00:00:00 EDT 2019

Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.

Nature immunology

Melum E,Jiang X,Baker KD,Macedo MF,Fritsch J,Dowds CM,Wang J,Pharo A,Kaser A,Tan C,Pereira CS,Kelly SL,Duan J,Karlsen TH,Exley MA,Schütze S,Zajonc DM,Merrill AH,Schuchman EH,Zeissig S,Blumberg RS

Sun Dec 01 00:00:00 EST 2019

Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis.

Frontiers in immunology

Li H,Lu T,Sun W,Ma R,Zhong H,Wei Y,Chen D,Wen Y,Carlsten C,Wen W

Tue Oct 20 00:00:00 EDT 2020

Thermoregulation via Temperature-Dependent PGD₂ Production in Mouse Preoptic Area.

Neuron

Wang TA,Teo CF,Åkerblom M,Chen C,Tynan-La Fontaine M,Greiner VJ,Diaz A,McManus MT,Jan YN,Jan LY

Wed Jul 17 00:00:00 EDT 2019

CD9 regulates keratinocyte migration by negatively modulating the sheddase activity of ADAM17.

International journal of biological sciences

Liu J,Zhu G,Jia N,Wang W,Wang Y,Yin M,Jiang X,Huang Y,Zhang J

Mon Jan 13 00:00:00 EST 2020

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.

Science advances

Arifuzzaman M,Mobley YR,Choi HW,Bist P,Salinas CA,Brown ZD,Chen SL,Staats HF,Abraham SN

Tue Jan 01 00:00:00 EST 2019

MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection.

Science advances

Arifuzzaman M,Mobley YR,Choi HW,Bist P,Salinas CA,Brown ZD,Chen SL,Staats HF,Abraham SN

Tue Jan 01 00:00:00 EST 2019

Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells.

Molecular medicine reports

Liu S,Hou H,Zhang P,Wu Y,He X,Li H,Yan N

Fri Feb 01 00:00:00 EST 2019

Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production.

Oncotarget

Kotredes KP,Razmpour R,Lutton E,Alfonso-Prieto M,Ramirez SH,Gamero AM

Fri Apr 12 00:00:00 EDT 2019

Different signalling in infarcted and non-infarcted areas of rat failing hearts: A role of necroptosis and inflammation.

Journal of cellular and molecular medicine

Lichý M,Szobi A,Hrdlička J,Horváth C,Kormanová V,Rajtík T,Neckář J,Kolář F,Adameová A

Sun Sep 01 00:00:00 EDT 2019

Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21.

Cancer management and research

Lyu K,Xu Y,Yue H,Li Y,Zhao J,Chen L,Wu J,Zhu X,Chai L,Li C,Wen W,Lei W

Sun Apr 10 00:00:00 EDT 2022

Potential roles of lncRNA-Cox2 and EGR1 in regulating epidural fibrosis following laminectomy.

European review for medical and pharmacological sciences

Qian ZY,Jiang F,Tang J,Ge DW,Chen HT,Zheng SN,Cao XJ,Ge YB,Yang L

Sun Sep 01 00:00:00 EDT 2019

Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery.

Cell death and differentiation

Wu N,Yuan Z,Du KY,Fang L,Lyu J,Zhang C,He A,Eshaghi E,Zeng K,Ma J,Du WW,Yang BB

Sun Dec 01 00:00:00 EST 2019

Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.

Frontiers in cell and developmental biology

Pruski M,Hu L,Yang C,Wang Y,Zhang JB,Zhang L,Huang Y,Rajnicek AM,St Clair D,McCaig CD,Lang B,Ding YQ

Thu Oct 01 00:00:00 EDT 2020

The mTOR-RUNX1 pathway regulates DC-SIGN expression in renal tubular epithelial cells.

Biochemical and biophysical research communications

Zhou S,Zhang L,Feng D,Luo M,Xie R,Yang K,Xu D,Yang K,Fei J,Zhou T

Tue Nov 12 00:00:00 EST 2019

Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.

International journal of molecular sciences

Hua L,Wu N,Zhao R,He X,Liu Q,Li X,He Z,Yu L,Yan N

Wed Jun 12 00:00:00 EDT 2019

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.

Science advances

Bosnakovski D,da Silva MT,Sunny ST,Ener ET,Toso EA,Yuan C,Cui Z,Walters MA,Jadhav A,Kyba M

Sun Sep 01 00:00:00 EDT 2019

CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.

Molecular and cellular probes

Li K,Meng Z,Jiang L,Xia C,Xu K,Yuan D,Chen H,Zhang B,Liu S

Mon Apr 01 00:00:00 EDT 2019

CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis.

Immunity

Liu J,Zhang X,Chen K,Cheng Y,Liu S,Xia M,Chen Y,Zhu H,Li Z,Cao X

Tue Mar 19 00:00:00 EDT 2019

The intestinal metal transporter ZIP14 maintains systemic manganese homeostasis.

The Journal of biological chemistry

Scheiber IF,Wu Y,Morgan SE,Zhao N

Fri Jun 07 00:00:00 EDT 2019

Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA) Requires Death Receptor Fas, in Addition to LFA-1, To Trigger Cell Death in T Lymphocytes.

Infection and immunity

Vega BA,Schober LT,Kim T,Belinka BA,Kachlany SC

Thu Aug 01 00:00:00 EDT 2019

Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.

Cell death & disease

Yang J,Zhang X,Chen Z,Shen Y,Wang F,Wang Y,Liu Y,Liu P,Yang J

Thu Feb 21 00:00:00 EST 2019

Anti-tumour immunity controlled through mRNA m⁶A methylation and YTHDF1 in dendritic cells.

Nature

Han D,Liu J,Chen C,Dong L,Liu Y,Chang R,Huang X,Liu Y,Wang J,Dougherty U,Bissonnette MB,Shen B,Weichselbaum RR,Xu MM,He C

Fri Feb 01 00:00:00 EST 2019

MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.

Journal of cell science

Xie S,Farmer T,Naslavsky N,Caplan S

Thu Nov 14 00:00:00 EST 2019

miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.

Scientific reports

Monteleone NJ,Moore AE,Iacona JR,Lutz CS,Dixon DA

Mon Apr 01 00:00:00 EDT 2019

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.

Communications biology

Horikoshi N,Sharma D,Leonard F,Pandita RK,Charaka VK,Hambarde S,Horikoshi NT,Gaur Khaitan P,Chakraborty S,Cote J,Godin B,Hunt CR,Pandita TK

Fri May 01 00:00:00 EDT 2020

Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.

Human reproduction (Oxford, England)

Gou Y,Li X,Li P,Zhang H,Xu T,Wang H,Wang B,Ma X,Jiang X,Zhang Z

Mon Apr 01 00:00:00 EDT 2019

Programmable RNA-Guided RNA Effector Proteins Built from Human Parts.

Cell

Rauch S,He E,Srienc M,Zhou H,Zhang Z,Dickinson BC

Thu Jun 27 00:00:00 EDT 2019

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma.

International journal of cancer

Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Couanet D,Michon J,Louis-Brennetot C,Janoueix-Lerosey I,Defachelles AS,Bourdeaut F,Delattre O,Schleiermacher G

Fri Nov 15 00:00:00 EST 2019

A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.

Cell transplantation

Xia B,Hong T,He X,Hu X,Gao Y

Sun Dec 01 00:00:00 EST 2019

Nicotinic acetylcholine receptor subunit expression in the gastrocnemius and in the orbicularis oris before and after facial nerve injury in rats.

Neurological research

Xu J,Huang Y,Li S,Chen L,Xue Z

Sun Sep 01 00:00:00 EDT 2019

Vascular Endothelial Growth Factor A Signaling Promotes Spinal Central Sensitization and Pain-related Behaviors in Female Rats with Bone Cancer.

Anesthesiology

Hu XM,Yang W,Du LX,Cui WQ,Mi WL,Mao-Ying QL,Chu YX,Wang YQ

Fri Nov 01 00:00:00 EDT 2019

Rutin promotes the formation and osteogenic differentiation of human periodontal ligament stem cell sheets in vitro.

International journal of molecular medicine

Zhao B,Zhang Y,Xiong Y,Xu X

Sun Dec 01 00:00:00 EST 2019

An Oxygen-Dependent Interaction between FBXL5 and the CIA-Targeting Complex Regulates Iron Homeostasis.

Molecular cell

Mayank AK,Pandey V,Vashisht AA,Barshop WD,Rayatpisheh S,Sharma T,Haque T,Powers DN,Wohlschlegel JA

Thu Jul 25 00:00:00 EDT 2019

Increased miRNA-518b inhibits trophoblast migration and angiogenesis by targeting EGR1 in early embryonic arrest†.

Biology of reproduction

Yang W,Lu Z,Zhi Z,Liu L,Deng L,Jiang X,Pang L

Fri Oct 25 00:00:00 EDT 2019

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.

Nature communications

Fons NR,Sundaram RK,Breuer GA,Peng S,McLean RL,Kalathil AN,Schmidt MS,Carvalho DM,Mackay A,Jones C,Carcaboso ÁM,Nazarian J,Berens ME,Brenner C,Bindra RS

Thu Aug 22 00:00:00 EDT 2019

Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL.

Cell death discovery

Shi CS,Kehrl JH

Tue Sep 29 00:00:00 EDT 2020

Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.

Molecular pharmacology

Chong KY,Kang M,Garofalo F,Ueno D,Liang H,Cady S,Madarikan O,Pitruzzello N,Tsai CH,Hartwich TMP,Shuch BM,Yang-Hartwich Y

Thu Aug 01 00:00:00 EDT 2019

Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Qin W,Wu X,Jia Y,Tong X,Guo C,Chen D,Wang Z,Tan N

Tue Oct 01 00:00:00 EDT 2019

Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.

International journal of molecular medicine

He Z,Du X,Wu Y,Hua L,Wan L,Yan N

Tue Oct 01 00:00:00 EDT 2019

Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration.

Cell death & disease

Zhang J,Zhang C,Jiang X,Li L,Zhang D,Tang D,Yan T,Zhang Q,Yuan H,Jia J,Hu J,Zhang J,Huang Y

Fri Mar 08 00:00:00 EST 2019

SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes.

Cell death discovery

Shi CS,Nabar NR,Huang NN,Kehrl JH

Thu Oct 01 00:00:00 EDT 2020

LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription.

Molecular cancer

Xiu B,Chi Y,Liu L,Chi W,Zhang Q,Chen J,Guo R,Si J,Li L,Xue J,Shao ZM,Wu ZH,Huang S,Wu J

Thu Dec 19 00:00:00 EST 2019

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

Thu Oct 04 00:00:00 EDT 2018

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

Thu Oct 04 00:00:00 EDT 2018

CD10⁺GPR77⁺ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.

Cell

Su S,Chen J,Yao H,Liu J,Yu S,Lao L,Wang M,Luo M,Xing Y,Chen F,Huang D,Zhao J,Yang L,Liao D,Su F,Li M,Liu Q,Song E

Thu Feb 08 00:00:00 EST 2018

CD10⁺GPR77⁺ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness.

Cell

Su S,Chen J,Yao H,Liu J,Yu S,Lao L,Wang M,Luo M,Xing Y,Chen F,Huang D,Zhao J,Yang L,Liao D,Su F,Li M,Liu Q,Song E

Thu Feb 08 00:00:00 EST 2018

A_2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21.

Cell metabolism

Ruan CC,Kong LR,Chen XH,Ma Y,Pan XX,Zhang ZB,Gao PJ

Tue Sep 04 00:00:00 EDT 2018

A_2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21.

Cell metabolism

Ruan CC,Kong LR,Chen XH,Ma Y,Pan XX,Zhang ZB,Gao PJ

Tue Sep 04 00:00:00 EDT 2018

m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Nature cell biology

Liu J,Eckert MA,Harada BT,Liu SM,Lu Z,Yu K,Tienda SM,Chryplewicz A,Zhu AC,Yang Y,Huang JT,Chen SM,Xu ZG,Leng XH,Yu XC,Cao J,Zhang Z,Liu J,Lengyel E,He C

Sat Sep 01 00:00:00 EDT 2018

m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Nature cell biology

Liu J,Eckert MA,Harada BT,Liu SM,Lu Z,Yu K,Tienda SM,Chryplewicz A,Zhu AC,Yang Y,Huang JT,Chen SM,Xu ZG,Leng XH,Yu XC,Cao J,Zhang Z,Liu J,Lengyel E,He C

Sat Sep 01 00:00:00 EDT 2018

Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.

Nucleic acids research

Lan Y,Xiao X,He Z,Luo Y,Wu C,Li L,Song X

Wed Jun 20 00:00:00 EDT 2018

Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.

Nucleic acids research

Lan Y,Xiao X,He Z,Luo Y,Wu C,Li L,Song X

Wed Jun 20 00:00:00 EDT 2018

Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.

Cell systems

Mao M,Hu Y,Yang Y,Qian Y,Wei H,Fan W,Yang Y,Li X,Wang Z

Wed Nov 28 00:00:00 EST 2018

Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning.

Cell systems

Mao M,Hu Y,Yang Y,Qian Y,Wei H,Fan W,Yang Y,Li X,Wang Z

Wed Nov 28 00:00:00 EST 2018

An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.

Molecular therapy. Nucleic acids

Cen B,Wei Y,Huang W,Teng M,He S,Li J,Wang W,He G,Bai X,Liu X,Yuan Y,Pan X,Ji A

Fri Dec 07 00:00:00 EST 2018

An Efficient Bivalent Cyclic RGD-PIK3CB siRNA Conjugate for Specific Targeted Therapy against Glioblastoma In Vitro and In Vivo.

Molecular therapy. Nucleic acids

Cen B,Wei Y,Huang W,Teng M,He S,Li J,Wang W,He G,Bai X,Liu X,Yuan Y,Pan X,Ji A

Fri Dec 07 00:00:00 EST 2018

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.

The Journal of cell biology

Papadopoulos N,Lennartsson J,Heldin CH

Mon May 07 00:00:00 EDT 2018

PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.

The Journal of cell biology

Papadopoulos N,Lennartsson J,Heldin CH

Mon May 07 00:00:00 EDT 2018

Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.

Phytotherapy research : PTR

Ci Y,Zhang Y,Liu Y,Lu S,Cao J,Li H,Zhang J,Huang Z,Zhu X,Gao J,Han M

Sun Jul 01 00:00:00 EDT 2018

Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.

Phytotherapy research : PTR

Ci Y,Zhang Y,Liu Y,Lu S,Cao J,Li H,Zhang J,Huang Z,Zhu X,Gao J,Han M

Sun Jul 01 00:00:00 EDT 2018

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.

International journal of molecular medicine

Zhang P,Hua L,Hou H,Du X,He Z,Liu M,Hu X,Yan N

Sat Dec 01 00:00:00 EST 2018

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway.

International journal of molecular medicine

Zhang P,Hua L,Hou H,Du X,He Z,Liu M,Hu X,Yan N

Sat Dec 01 00:00:00 EST 2018

Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.

Journal of cellular and molecular medicine

Li P,Feng C,Chen H,Jiang Y,Cao F,Liu J,Liu P

Sun Jul 01 00:00:00 EDT 2018

Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.

Journal of cellular and molecular medicine

Li P,Feng C,Chen H,Jiang Y,Cao F,Liu J,Liu P

Sun Jul 01 00:00:00 EDT 2018

AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.

Journal of cellular and molecular medicine

Chen ZL,Yang J,Shen YW,Li ST,Wang X,Lv M,Wang BY,Li P,Zhao W,Qiu RY,Liu Y,Liu PJ,Yang J

Sun Apr 01 00:00:00 EDT 2018

AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.

Journal of cellular and molecular medicine

Chen ZL,Yang J,Shen YW,Li ST,Wang X,Lv M,Wang BY,Li P,Zhao W,Qiu RY,Liu Y,Liu PJ,Yang J

Sun Apr 01 00:00:00 EDT 2018

β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.

Molecular and cellular biology

Ahmed KM,Pandita RK,Singh DK,Hunt CR,Pandita TK

Tue May 01 00:00:00 EDT 2018

β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.

Molecular and cellular biology

Ahmed KM,Pandita RK,Singh DK,Hunt CR,Pandita TK

Tue May 01 00:00:00 EDT 2018

Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways.

Inflammation

Wang S,Wei J,Fan Y,Ding H,Tian H,Zhou X,Cheng L

Mon Oct 01 00:00:00 EDT 2018

Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways.

Inflammation

Wang S,Wei J,Fan Y,Ding H,Tian H,Zhou X,Cheng L

Mon Oct 01 00:00:00 EDT 2018

FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.

Journal of Cancer

Lan Y,Xiao X,Luo Y,He Z,Song X

Wed Sep 30 00:00:00 EDT 2020

FEZF1 is an Independent Predictive Factor for Recurrence and Promotes Cell Proliferation and Migration in Cervical Cancer.

Journal of Cancer

Lan Y,Xiao X,Luo Y,He Z,Song X

Wed Sep 30 00:00:00 EDT 2020

An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering.

Stem cells and development

Zhang Y,Xing Y,Jia L,Ji Y,Zhao B,Wen Y,Xu X

Sat Dec 01 00:00:00 EST 2018

An In Vitro Comparative Study of Multisource Derived Human Mesenchymal Stem Cells for Bone Tissue Engineering.

Stem cells and development

Zhang Y,Xing Y,Jia L,Ji Y,Zhao B,Wen Y,Xu X

Sat Dec 01 00:00:00 EST 2018

hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1.

Oncology reports

He X,Fan S

Thu Mar 01 00:00:00 EST 2018

hsa-miR-212 modulates the radiosensitivity of glioma cells by targeting BRCA1.

Oncology reports

He X,Fan S

Thu Mar 01 00:00:00 EST 2018

High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.

Oncology reports

Chen Y,Liu J,Wang W,Xiang L,Wang J,Liu S,Zhou H,Guo Z

Sun Apr 01 00:00:00 EDT 2018

High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.

Oncology reports

Chen Y,Liu J,Wang W,Xiang L,Wang J,Liu S,Zhou H,Guo Z

Sun Apr 01 00:00:00 EDT 2018

The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.

Experimental biology and medicine (Maywood, N.J.)

Li J,Liu J,Li P,Zhou C,Liu P

Sat Sep 01 00:00:00 EDT 2018

The downregulation of WWOX induces epithelial-mesenchymal transition and enhances stemness and chemoresistance in breast cancer.

Experimental biology and medicine (Maywood, N.J.)

Li J,Liu J,Li P,Zhou C,Liu P

Sat Sep 01 00:00:00 EDT 2018

Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging.

Cardiovascular drugs and therapy

Pan XX,Cao JM,Cai F,Ruan CC,Wu F,Gao PJ

Mon Oct 01 00:00:00 EDT 2018

Loss of miR-146b-3p Inhibits Perivascular Adipocyte Browning with Cold Exposure During Aging.

Cardiovascular drugs and therapy

Pan XX,Cao JM,Cai F,Ruan CC,Wu F,Gao PJ

Mon Oct 01 00:00:00 EDT 2018

Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway.

Journal of periodontal research

Wang LM,Zhao N,Zhang J,Sun QF,Yang CZ,Yang PS

Thu Feb 01 00:00:00 EST 2018

Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway.

Journal of periodontal research

Wang LM,Zhao N,Zhang J,Sun QF,Yang CZ,Yang PS

Thu Feb 01 00:00:00 EST 2018

After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.

Basic & clinical pharmacology & toxicology

Zhao N,Liang P,Zhuo X,Su C,Zong X,Guo B,Han D,Yan X,Hu S,Zhang Q,Tie X

Tue May 01 00:00:00 EDT 2018

Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats.

Journal of chemical neuroanatomy

Liu SY,Chen L,Li XC,Hu QK,He LJ

Sun Apr 01 00:00:00 EDT 2018

Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats.

Journal of chemical neuroanatomy

Liu SY,Chen L,Li XC,Hu QK,He LJ

Sun Apr 01 00:00:00 EDT 2018

Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea.

Experimental and therapeutic medicine

Xiong RH,Wen SL,Wang Q,Zhou HY,Feng S

Mon Jan 01 00:00:00 EST 2018

Morphological and molecular variations induce mitochondrial dysfunction as a possible underlying mechanism of athletic amenorrhea.

Experimental and therapeutic medicine

Xiong RH,Wen SL,Wang Q,Zhou HY,Feng S

Mon Jan 01 00:00:00 EST 2018

Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.

Evidence-based complementary and alternative medicine : eCAM

Zhou J,Zhang C,Zheng GH,Qiu Z

Thu Oct 01 00:00:00 EDT 2020

Emblic Leafflower (Phyllanthus emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A.

Evidence-based complementary and alternative medicine : eCAM

Zhou J,Zhang C,Zheng GH,Qiu Z

Thu Oct 01 00:00:00 EDT 2020

The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.

Bioscience, biotechnology, and biochemistry

Yu G,Liao J,Wu J,Ding J,Zhang L

Mon Oct 01 00:00:00 EDT 2018

The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.

Bioscience, biotechnology, and biochemistry

Yu G,Liao J,Wu J,Ding J,Zhang L

Mon Oct 01 00:00:00 EDT 2018

Transcriptome analysis reveals the mechanism of the effect of flower tea Coreopsis tinctoria on hepatic insulin resistance.

Food & function

Jiang B,Lv Q,Wan W,Le L,Xu L,Hu K,Xiao P

Wed Nov 14 00:00:00 EST 2018

Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.

Frontiers in physiology

Kong LR,Zhou YP,Chen DR,Ruan CC,Gao PJ

Tue Sep 29 00:00:00 EDT 2020

Decrease of Perivascular Adipose Tissue Browning Is Associated With Vascular Dysfunction in Spontaneous Hypertensive Rats During Aging.

Frontiers in physiology

Kong LR,Zhou YP,Chen DR,Ruan CC,Gao PJ

Tue Sep 29 00:00:00 EDT 2020

mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways.

Journal of neuroscience research

Yu J,Yang H,Fang B,Zhang Z,Wang Y,Dai Y

Mon Jan 01 00:00:00 EST 2018

Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.

Autoimmunity

Tang H,Bai Y,Pan G,Wang X,Wei Y,Yang Z,Zhao J

Sat Dec 01 00:00:00 EST 2018

Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.

Frontiers in pharmacology

Xiang Z,Huang X,Wang J,Zhang J,Ji J,Yan R,Zhu Z,Cai W,Yu Y

Fri Nov 03 00:00:00 EDT 2023

Cross-Database Analysis Reveals Sensitive Biomarkers for Combined Therapy for ERBB2+ Gastric Cancer.

Frontiers in pharmacology

Xiang Z,Huang X,Wang J,Zhang J,Ji J,Yan R,Zhu Z,Cai W,Yu Y

Fri Nov 03 00:00:00 EDT 2023

Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.

Cell reports

Smith Q,Macklin B,Chan XY,Jones H,Trempel M,Yoder MC,Gerecht S

Tue Jul 24 00:00:00 EDT 2018

Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.

Cell reports

Smith Q,Macklin B,Chan XY,Jones H,Trempel M,Yoder MC,Gerecht S

Tue Jul 24 00:00:00 EDT 2018

Yu Gan Long reduces rat liver fibrosis by blocking TGF-β1/Smad pathway and modulating the immunity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Xia Y,Yu B,Ma C,Tu Y,Zhai L,Yang Y,Liu D,Liu Y,Wu H,Dan H,You P

Mon Oct 01 00:00:00 EDT 2018

β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.

PLoS genetics

Xie X,Jankauskas R,Mazari AMA,Drou N,Percipalle P

Sat Dec 01 00:00:00 EST 2018

β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming.

PLoS genetics

Xie X,Jankauskas R,Mazari AMA,Drou N,Percipalle P

Sat Dec 01 00:00:00 EST 2018

Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.

Frontiers in pharmacology

Li X,Qiu Z,Jin Q,Chen G,Guo M

Fri Nov 03 00:00:00 EDT 2023

Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.

Frontiers in pharmacology

Li X,Qiu Z,Jin Q,Chen G,Guo M

Fri Nov 03 00:00:00 EDT 2023

miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.

Oncotarget

Iacona JR,Monteleone NJ,Lutz CS

Fri Jun 01 00:00:00 EDT 2018

miR-146a suppresses 5-lipoxygenase activating protein (FLAP) expression and Leukotriene B4 production in lung cancer cells.

Oncotarget

Iacona JR,Monteleone NJ,Lutz CS

Fri Jun 01 00:00:00 EDT 2018

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.

Cell chemical biology

Rinis N,Golden JE,Marceau CD,Carette JE,Van Zandt MC,Gilmore R,Contessa JN

Thu Oct 18 00:00:00 EDT 2018

Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors.

Cell chemical biology

Rinis N,Golden JE,Marceau CD,Carette JE,Van Zandt MC,Gilmore R,Contessa JN

Thu Oct 18 00:00:00 EDT 2018

Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling.

European journal of immunology

Hertzog J,Dias Junior AG,Rigby RE,Donald CL,Mayer A,Sezgin E,Song C,Jin B,Hublitz P,Eggeling C,Kohl A,Rehwinkel J

Sun Jul 01 00:00:00 EDT 2018

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.

The Journal of clinical investigation

Bianchi-Smiraglia A,Bagati A,Fink EE,Affronti HC,Lipchick BC,Moparthy S,Long MD,Rosario SR,Lightman SM,Moparthy K,Wolff DW,Yun DH,Han Z,Polechetti A,Roll MV,Gitlin II,Leonova KI,Rowsam AM,Kandel ES,Gudkov AV,Bergsagel PL,Lee KP,Smiraglia DJ,Nikiforov MA

Mon Oct 01 00:00:00 EDT 2018

The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.

The Journal of biological chemistry

Purandare N,Somayajulu M,Hüttemann M,Grossman LI,Aras S

Fri Apr 27 00:00:00 EDT 2018

The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.

The Journal of biological chemistry

Purandare N,Somayajulu M,Hüttemann M,Grossman LI,Aras S

Fri Apr 27 00:00:00 EDT 2018

Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.

Cancer research

Lopez Sambrooks C,Baro M,Quijano A,Narayan A,Cui W,Greninger P,Egan R,Patel A,Benes CH,Saltzman WM,Contessa JN

Sat Sep 01 00:00:00 EDT 2018

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

Cell

Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X

Thu Jul 27 00:00:00 EDT 2017

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

Cell

Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X

Thu Jul 27 00:00:00 EDT 2017

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.

Cell

Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X

Thu Jul 27 00:00:00 EDT 2017

Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.

Diabetes

Lu T,Sun X,Li Y,Chai Q,Wang XL,Lee HC

Sun Oct 01 00:00:00 EDT 2017

Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice.

Diabetes

Lu T,Sun X,Li Y,Chai Q,Wang XL,Lee HC

Sun Oct 01 00:00:00 EDT 2017

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.

Biological research

Gan Z,Han K,Lin S,Hu H,Shen Z,Min D

Wed Apr 12 00:00:00 EDT 2017

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.

Biological research

Gan Z,Han K,Lin S,Hu H,Shen Z,Min D

Wed Apr 12 00:00:00 EDT 2017

Long non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier via miR-181d-5p-mediated expression changes in ZO-1, occludin, and claudin-5.

Biochimica et biophysica acta. Molecular basis of disease

Guo J,Cai H,Zheng J,Liu X,Liu Y,Ma J,Que Z,Gong W,Gao Y,Tao W,Xue Y

Fri Sep 01 00:00:00 EDT 2017

Long non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier via miR-181d-5p-mediated expression changes in ZO-1, occludin, and claudin-5.

Biochimica et biophysica acta. Molecular basis of disease

Guo J,Cai H,Zheng J,Liu X,Liu Y,Ma J,Que Z,Gong W,Gao Y,Tao W,Xue Y

Fri Sep 01 00:00:00 EDT 2017

CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.

Oncogenesis

Li P,Wang Y,Mao X,Jiang Y,Liu J,Li J,Wang J,Wang R,She J,Zhang J,Yang J,Liu Y,Liu P

Mon Apr 24 00:00:00 EDT 2017

CRB3 downregulation confers breast cancer stem cell traits through TAZ/β-catenin.

Oncogenesis

Li P,Wang Y,Mao X,Jiang Y,Liu J,Li J,Wang J,Wang R,She J,Zhang J,Yang J,Liu Y,Liu P

Mon Apr 24 00:00:00 EDT 2017

Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Shah SZA,Zhao D,Taglialatela G,Khan SH,Hussain T,Dong H,Lai M,Zhou X,Yang L

Sat Apr 01 00:00:00 EDT 2017

Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Shah SZA,Zhao D,Taglialatela G,Khan SH,Hussain T,Dong H,Lai M,Zhou X,Yang L

Sat Apr 01 00:00:00 EDT 2017

p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.

Disease models & mechanisms

Bosnakovski D,Gearhart MD,Toso EA,Recht OO,Cucak A,Jain AK,Barton MC,Kyba M

Sun Oct 01 00:00:00 EDT 2017

p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy.

Disease models & mechanisms

Bosnakovski D,Gearhart MD,Toso EA,Recht OO,Cucak A,Jain AK,Barton MC,Kyba M

Sun Oct 01 00:00:00 EDT 2017

The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.

Oncology reports

Zhao Y,Xie X,Liao W,Zhang H,Cao H,Fei R,Wang X,Wei L,Shao Q,Chen H

Sun Jan 01 00:00:00 EST 2017

The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.

Oncology reports

Zhao Y,Xie X,Liao W,Zhang H,Cao H,Fei R,Wang X,Wei L,Shao Q,Chen H

Sun Jan 01 00:00:00 EST 2017

Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.

Oncology reports

Feng YZ,Zhang QY,Fu MT,Zhang ZF,Wei M,Zhou JY,Shi R

Sat Jul 01 00:00:00 EDT 2017

Low expression of PinX1 is associated with malignant behavior in basal-like breast cancer.

Oncology reports

Feng YZ,Zhang QY,Fu MT,Zhang ZF,Wei M,Zhou JY,Shi R

Sat Jul 01 00:00:00 EDT 2017

Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

Environmental toxicology

Li C,Li L,Lin B,Fang Y,Yang H,Liu H,Xi Z

Thu Jun 01 00:00:00 EDT 2017

Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

Environmental toxicology

Li C,Li L,Lin B,Fang Y,Yang H,Liu H,Xi Z

Thu Jun 01 00:00:00 EDT 2017

Correspondence: Assessment of learning, memory and attention in developmental neurotoxicology.

Neurotoxicology and teratology

Sobin C

Wed Jun 06 00:00:00 EDT 2018

Correspondence: Assessment of learning, memory and attention in developmental neurotoxicology.

Neurotoxicology and teratology

Sobin C

Wed Jun 06 00:00:00 EDT 2018

N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.

Molecular medicine reports

Zhang Y,Cui W,Zhai Q,Zhang T,Wen X

Tue Aug 01 00:00:00 EDT 2017

The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis.

Oncology letters

Li H,Qiu Z,Li F,Wang C

Wed Nov 01 00:00:00 EDT 2017

The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis.

Oncology letters

Li H,Qiu Z,Li F,Wang C

Wed Nov 01 00:00:00 EDT 2017

miRNA-346 promotes proliferation, migration and invasion in liver cancer.

Oncology letters

Yu Q,Yang X,Duan W,Li C,Luo Y,Lu S

Fri Sep 01 00:00:00 EDT 2017

miRNA-346 promotes proliferation, migration and invasion in liver cancer.

Oncology letters

Yu Q,Yang X,Duan W,Li C,Luo Y,Lu S

Fri Sep 01 00:00:00 EDT 2017

A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.

International journal of ophthalmology

Cui XK,Zhu KK,Zhou Z,Wan SM,Dong Y,Wang XC,Li J,Zhang J,Mu HM,Qin L,Hu YZ

Wed Sep 30 00:00:00 EDT 2020

A novel frameshift mutation in CX46 associated with hereditary dominant cataracts in a Chinese family.

International journal of ophthalmology

Cui XK,Zhu KK,Zhou Z,Wan SM,Dong Y,Wang XC,Li J,Zhang J,Mu HM,Qin L,Hu YZ

Wed Sep 30 00:00:00 EDT 2020

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.

Nature structural & molecular biology

Chen YA,Shen YL,Hsia HY,Tiang YP,Sung TL,Chen LY

Fri Dec 01 00:00:00 EST 2017

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway.

Nature structural & molecular biology

Chen YA,Shen YL,Hsia HY,Tiang YP,Sung TL,Chen LY

Fri Dec 01 00:00:00 EST 2017

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.

Scientific reports

Li C,Zhang J,Wu H,Li L,Yang C,Song S,Peng P,Shao M,Zhang M,Zhao J,Zhao R,Wu W,Ruan Y,Wang L,Gu J

Mon Mar 27 00:00:00 EDT 2017

Lectin-like oxidized low-density lipoprotein receptor-1 facilitates metastasis of gastric cancer through driving epithelial-mesenchymal transition and PI3K/Akt/GSK3β activation.

Scientific reports

Li C,Zhang J,Wu H,Li L,Yang C,Song S,Peng P,Shao M,Zhang M,Zhao J,Zhao R,Wu W,Ruan Y,Wang L,Gu J

Mon Mar 27 00:00:00 EDT 2017

Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish.

eLife

Granneman JG,Kimler VA,Zhang H,Ye X,Luo X,Postlethwait JH,Thummel R

Tue Feb 28 00:00:00 EST 2017

Lipid droplet biology and evolution illuminated by the characterization of a novel perilipin in teleost fish.

eLife

Granneman JG,Kimler VA,Zhang H,Ye X,Luo X,Postlethwait JH,Thummel R

Tue Feb 28 00:00:00 EST 2017

Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.

International journal of molecular sciences

Chen HY,Huang TC,Shieh TM,Wu CH,Lin LC,Hsia SM

Thu Sep 21 00:00:00 EDT 2017

Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.

International journal of molecular sciences

Chen HY,Huang TC,Shieh TM,Wu CH,Lin LC,Hsia SM

Thu Sep 21 00:00:00 EDT 2017

Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.

International journal of molecular sciences

Milewski K,Bogacińska-Karaś M,Fręśko I,Hilgier W,Jaźwiec R,Albrecht J,Zielińska M

Thu Nov 02 00:00:00 EDT 2017

Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.

International journal of molecular sciences

Milewski K,Bogacińska-Karaś M,Fręśko I,Hilgier W,Jaźwiec R,Albrecht J,Zielińska M

Thu Nov 02 00:00:00 EDT 2017

Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP.

Scientific reports

Fragkouli A,Koukouraki P,Vlachos IS,Paraskevopoulou MD,Hatzigeorgiou AG,Doxakis E

Tue Mar 14 00:00:00 EDT 2017

Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP.

Scientific reports

Fragkouli A,Koukouraki P,Vlachos IS,Paraskevopoulou MD,Hatzigeorgiou AG,Doxakis E

Tue Mar 14 00:00:00 EDT 2017

MTA1 promotes epithelial to mesenchymal transition and metastasis in non-small-cell lung cancer.

Oncotarget

Ma K,Fan Y,Dong X,Dong D,Guo Y,Wei X,Ning J,Geng Q,Wang C,Hu Y,Li M,Niu W,Li E,Wu Y

Tue Jun 13 00:00:00 EDT 2017

Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting.

Journal of biomedical research

Li Z,Yang HY,Wang Y,Zhang ML,Liu XR,Xiong Q,Zhang LN,Jin Y,Mou LS,Liu Y,Li RF,Rao Y,Dai YF

Tue Sep 26 00:00:00 EDT 2017

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.

Journal of neurochemistry

Zielińska M,Dąbrowska K,Hadera MG,Sonnewald U,Albrecht J

Fri Jan 01 00:00:00 EST 2016

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.

Journal of neurochemistry

Zielińska M,Dąbrowska K,Hadera MG,Sonnewald U,Albrecht J

Fri Jan 01 00:00:00 EST 2016

Eupolyphaga sinensis Walker Ethanol Extract Suppresses Cell Growth and Invasion in Human Breast Cancer Cells.

Integrative cancer therapies

Zhan Y,Zhang H,Liu R,Wang W,Qi J,Zhang Y

Tue Mar 01 00:00:00 EST 2016

Eupolyphaga sinensis Walker Ethanol Extract Suppresses Cell Growth and Invasion in Human Breast Cancer Cells.

Integrative cancer therapies

Zhan Y,Zhang H,Liu R,Wang W,Qi J,Zhang Y

Tue Mar 01 00:00:00 EST 2016

Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice.

Oncotarget

Wu CH,Chen HY,Wang CW,Shieh TM,Huang TC,Lin LC,Wang KL,Hsia SM

Tue Nov 08 00:00:00 EST 2016

c-Myc plays a key role in TADs-induced apoptosis and cell cycle arrest in human hepatocellular carcinoma cells.

American journal of cancer research

Zhang D,Qi J,Liu R,Dai B,Ma W,Zhan Y,Zhang Y

Fri Jun 05 00:00:00 EDT 2015

Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma.

International journal of oncology

Mao X,Li P,Ren Y,Li J,Zhou C,Yang J,Liu P

Sun Feb 01 00:00:00 EST 2015

Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma.

International journal of oncology

Mao X,Li P,Ren Y,Li J,Zhou C,Yang J,Liu P

Sun Feb 01 00:00:00 EST 2015

Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.

Experimental cell research

He Y,Cao X,Liu X,Li X,Xu Y,Liu J,Shi J

Sun Nov 15 00:00:00 EST 2015

Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.

Experimental cell research

He Y,Cao X,Liu X,Li X,Xu Y,Liu J,Shi J

Sun Nov 15 00:00:00 EST 2015

Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.

Molecular medicine reports

Liu R,Wang W,Dai B,Liu Y,Zhang Y

Sun Nov 01 00:00:00 EDT 2015

Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation.

BioMed research international

He T,Zhao L,Zhang D,Zhang Q,Jia J,Hu J,Huang Y

Wed Aug 17 00:00:00 EDT 2016

Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation.

BioMed research international

He T,Zhao L,Zhang D,Zhang Q,Jia J,Hu J,Huang Y

Wed Aug 17 00:00:00 EDT 2016

Elabela-apelin receptor signaling pathway is functional in mammalian systems.

Scientific reports

Wang Z,Yu D,Wang M,Wang Q,Kouznetsova J,Yang R,Qian K,Wu W,Shuldiner A,Sztalryd C,Zou M,Zheng W,Gong DW

Mon Feb 02 00:00:00 EST 2015

Elabela-apelin receptor signaling pathway is functional in mammalian systems.

Scientific reports

Wang Z,Yu D,Wang M,Wang Q,Kouznetsova J,Yang R,Qian K,Wu W,Shuldiner A,Sztalryd C,Zou M,Zheng W,Gong DW

Mon Feb 02 00:00:00 EST 2015

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.

Nature communications

Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

Mon Oct 05 00:00:00 EDT 2015

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.

Nature communications

Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E

Mon Oct 05 00:00:00 EDT 2015

Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.

Archives of pharmacal research

Zhan Y,Chen Y,Liu R,Zhang H,Zhang Y

Fri Aug 01 00:00:00 EDT 2014

Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.

Archives of pharmacal research

Zhan Y,Chen Y,Liu R,Zhang H,Zhang Y

Fri Aug 01 00:00:00 EDT 2014

Momordica cochinchinensis seed extracts suppress migration and invasion of human breast cancer ZR-75-30 cells via down-regulating MMP-2 and MMP-9.

Asian Pacific journal of cancer prevention : APJCP

Zheng L,Zhang YM,Zhan YZ,Liu CX

Tue Nov 18 00:00:00 EST 2014

Momordica cochinchinensis seed extracts suppress migration and invasion of human breast cancer ZR-75-30 cells via down-regulating MMP-2 and MMP-9.

Asian Pacific journal of cancer prevention : APJCP

Zheng L,Zhang YM,Zhan YZ,Liu CX

Tue Nov 18 00:00:00 EST 2014

Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.

Scientific reports

Zhang Y,Zhan Y,Zhang D,Dai B,Ma W,Qi J,Liu R,He L

Tue Jul 01 00:00:00 EDT 2014

Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.

Scientific reports

Zhang Y,Zhan Y,Zhang D,Dai B,Ma W,Qi J,Liu R,He L

Tue Jul 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: 38 kDa BFA-dependent ADP-ribosylation substrate; aging-associated gene 9 protein; BARS-38; EC 1.2.1.12; epididymis secretory protein Li 278; epididymis secretory sperm binding protein Li 162eP; GAPDH; GAPDH-2; glyceraldehyde 3-phosphate dehydrogenase, testis-specific; Glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-phosphate dehydrogenase 2; glyceraldehyde-3-phosphate dehydrogenase type 2; Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; HGNC:4141; MGC88685; Peptidyl-cysteine S-nitrosylase GAPDH; Spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase 2; Spermatogenic glyceraldehyde-3-phosphate dehydrogenase

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Gene Aliases: BARS-38; bb02e05; cb350; cb609; CDABP0047; fb71f08; fk58c09; G3PD; g3pdh; GAPD; Gapd-s; GAPD2; GAPDH; GAPDH-2; GAPDH2; GAPDHS; GAPDS; HEL-S-162eP; HEL-S-278; HSD-35; HSD35; mg:bb02e05; OK/SW-cl.12; wu:fb33a10; wu:fb71f08; wu:fk58c09; wu:ft80f05; zgc:76908

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UniProt ID: (Human) P04406, (Human) O14556, (Mouse) P16858, (Rat) P04797, (Rat) Q9ESV6, (Mouse) Q64467, (Zebrafish) Q5XJ10, (Zebrafish) Q5MJ86

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Entrez Gene ID: (Human) 2597, (Human) 26330, (Mouse) 14433, (Rat) 24383, (Rat) 66020, (Mouse) 14447, (Zebrafish) 317743, (Zebrafish) 406367

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Function(s)

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity protein binding microtubule binding peptidyl-cysteine S-nitrosylase activity identical protein binding NADP binding NAD binding molecular_function oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor transferase activity nucleotide binding dehydrogenase

Process(es)

microtubule cytoskeleton organization gluconeogenesis regulation of macroautophagy negative regulation of translation peptidyl-cysteine S-trans-nitrosylation protein stabilization neuron apoptotic process canonical glycolysis cellular response to interferon-gamma spermatid development sperm motility positive regulation of glycolytic process carbohydrate metabolic process glycolytic process apoptotic process multicellular organism development oxidation-reduction process response to ammonium ion regulation of translation glucose metabolic process

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GAPDH Monoclonal Antibody (1E6D9), HRP

GAPDH Antibody (HRP-60004) in WB

Product Details

HRP-60004

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

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Published species

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Bioinformatics

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