Product References
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease.
Acta pharmacologica Sinica
Dong AQ,Yang YP,Jiang SM,Yao XY,Qi D,Mao CJ,Cheng XY,Wang F,Hu LF,Liu CF
13-0300 was used in Immunohistochemistry to demonstrate an anti-neuroinflammatory activity of PPX via a Drd3-dependent enhancement of autophagy activity in astrocytes, and reveals a new mechanism for the beneficial effect of PPX in PD therapy.
Sun Jan 01 00:00:00 EST 2023
TGFβR-1/ALK5 inhibitor RepSox induces enteric glia-to-neuron transition and influences gastrointestinal mobility in adult mice.
Acta pharmacologica Sinica
Shi CJ,Lian JJ,Zhang BW,Cha JX,Hua QH,Pi XP,Hou YJ,Xie X,Zhang R
13-0300 was used in Immunocytochemistry-immunoflourescence to provide a method for efficiently converting adult mouse EGCs into neurons by small-molecule compounds, which might be a promising therapeutic strategy for gastrointestinal neuropathy.
Sun Jan 01 00:00:00 EST 2023
Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models.
International journal of molecular sciences
Calbiague García V,Cadiz B,Herrera P,Díaz A,Schmachtenberg O
13-0300 was used in Immunohistochemistry-immunofluorescence to test two unconventional and potentially complementary non-invasive treatment options for diabetic retinopathy.
Thu Apr 27 00:00:00 EDT 2023
Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning.
eNeuro
Fleischer P,Abbasi A,Fealy AW,Danielsen NP,Sandhu R,Raj PR,Gulati T
13-0300 was used in Immunohistochemistry-immunofluorescence to find that these neural dynamics were more prominently expressed during accurate behavior in the M1.
Wed Feb 01 00:00:00 EST 2023
The effect of Abi3 locus deletion on the progression of Alzheimer's disease-related pathologies.
Frontiers in immunology
Karahan H,Smith DC,Kim B,McCord B,Mantor J,John SK,Al-Amin MM,Dabin LC,Kim J
13-0300 was used in Immunohistochemistry to suggest that loss of ABI3 function may exacerbate AD progression by increasing Aβ accumulation and inflammation starting from earlier stages of the pathology.
Fri Mar 17 00:00:00 EDT 2023
The Imbalance of Astrocytic Mitochondrial Dynamics Following Blast-Induced Traumatic Brain Injury.
Biomedicines
Guilhaume-Correa F,Pickrell AM,VandeVord PJ
13-0300 was used in Immunocytochemistry to show a time-dependent reactive astrocyte phenotype transition in the rat hippocampus.
Tue Jan 24 00:00:00 EST 2023
The Imbalance of Astrocytic Mitochondrial Dynamics Following Blast-Induced Traumatic Brain Injury.
Biomedicines
Guilhaume-Correa F,Pickrell AM,VandeVord PJ
13-0300 was used in Immunocytochemistry to show a time-dependent reactive astrocyte phenotype transition in the rat hippocampus.
Tue Jan 24 00:00:00 EST 2023
An In Vivo Platform for Rebuilding Functional Neocortical Tissue.
Bioengineering (Basel, Switzerland)
Quezada A,Ward C,Bader ER,Zolotavin P,Altun E,Hong S,Killian NJ,Xie C,Batista-Brito R,Hébert JM
13-0300 was used in Immunohistochemistry-immunofluorescence to provide proof of a concept for an in vivo platform that can be used for developing and testing neocortical-like tissue prototypes.
Thu Feb 16 00:00:00 EST 2023
Translatome analysis reveals microglia and astrocytes to be distinct regulators of inflammation in the hyperacute and acute phases after stroke.
Glia
Hernandez VG,Lechtenberg KJ,Peterson TC,Zhu L,Lucas TA,Bradshaw KP,Owah JO,Dorsey AI,Gentles AJ,Buckwalter MS
13-0300 was used in Immunohistochemistry to describe the microglia and astrocyte-specific translatome response in the hyperacute and acute period after stroke and identify pathways critical for initiating neuroinflammation.
Tue Aug 01 00:00:00 EDT 2023
The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke.
Journal of neuroinflammation
Wang C,Li L
13-0300 was used in Immunohistochemistry-immunofluorescence to demonstrate that astrocytic KLF4 expression and complement C3-positive A1 and S100 calcium binding protein A10 (S100A10)-positive A2 astrocytes were induced in the ischemic penumbra following focal cerebral ischemia, and the time course of upregulation of astrocytic KLF4 correlated closely with the activation of A2 astrocytes.
Thu Feb 23 00:00:00 EST 2023
A simplified protocol for the generation of cortical brain organoids.
Frontiers in cellular neuroscience
Eigenhuis KN,Somsen HB,van der Kroeg M,Smeenk H,Korporaal AL,Kushner SA,de Vrij FMS,van den Berg DLC
13-0300 was used in Immunohistochemistry-immunofluorescence to describe a detailed, simplified protocol for the robust and reproducible generation of brain organoids with cortical identity from feeder-independent induced pluripotent stem cells (iPSCs).
Sat Apr 22 00:00:00 EDT 2023
Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression.
Acta pharmaceutica Sinica. B
Tang C,Wang Q,Shen J,Wang C,Ding H,Wen S,Yang F,Jiao R,Wu X,Li J,Kong L
13-0300 was used in Immunohistochemistry-immunofluorescence to demonstrate that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs, and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression.
Mon May 01 00:00:00 EDT 2023
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke.
Journal of biomedical science
Dzyubenko E,Willig KI,Yin D,Sardari M,Tokmak E,Labus P,Schmermund B,Hermann DM
13-0300 was used in Immunohistochemistry to propose that prolonging PNN loosening during the post-acute period can extend the opening neuroplasticity window into the chronic stroke phase.
Fri Sep 01 00:00:00 EDT 2023
Brain region dependent molecular signatures and myelin repair following chronic demyelination.
Frontiers in cellular neuroscience
Samtani G,Kim S,Michaud D,Hillhouse AE,Szule JA,Konganti K,Li J
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate spatiotemporal characteristics of acute and chronic de- and remyelination and motor functional recovery following chronic demyelination.
Tue May 16 00:00:00 EDT 2023
Gadolinium retention in the ischemic cerebrum: Implications for pain, neuron loss, and neurological deficits.
Magnetic resonance in medicine
Huang XX,Jiang RH,Xu XQ,Wang W,Sun YQ,Li L,Shi HB,Liu S
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate the effects of gadolinium (Gd) retention of macrocyclic (gadobutrol) or linear (gadopentetate) Gd-based contrast agents (GBCAs) on neuron loss, neurological deficits, and sensory behavior in mice with or without stroke.
Sun Jan 01 00:00:00 EST 2023
A critical role for erythropoietin on vagus nerve Schwann cells in intestinal motility.
BMC biotechnology
Govindappa PK,Begom M,Gupta Y,Elfar JC,Rawat M,Elfar W
13-0300 was used in Immunohistochemistry-immunofluorescence to suggest that EPO-EPOR signaling in the vagus nerve after postoperative ileus is important for the functional recovery of intestinal transit time.
Mon May 01 00:00:00 EDT 2023
Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia.
Cells
Elabi OF,Espa E,Skovgård K,Fanni S,Cenci MA
13-0300 was used in Immunohistochemistry to compare the effects of L-DOPA and ropinirole, alone or in combination, on patterns of glial and microvascular reactivity in the striatum.
Fri Jul 14 00:00:00 EDT 2023
A closed-body preclinical model to investigate blast-induced spinal cord injury.
Frontiers in molecular neuroscience
Norris C,Weatherbee J,Murphy S,Marquetti I,Maniakhina L,Boruch A,VandeVord P
13-0300 was used in Immunohistochemistry to indicate that pathophysiological responses from the blast alone are detectable, likely contributing to the combined effects.
Sun Jul 02 00:00:00 EDT 2023
Multiplex translaminar imaging in the spinal cord of behaving mice.
Nature communications
Shekhtmeyster P,Carey EM,Duarte D,Ngo A,Gao G,Nelson NA,Clark CL,Nimmerjahn A
13-0300 was used in Immunohistochemistry to show that tachykinin precursor 1 (Tac1)-expressing neurons exhibit translaminar activity to acute mechanical pain but not locomotion.
Tue Mar 21 00:00:00 EDT 2023
Targeting chemoattractant chemokine (C-C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders.
Frontiers in immunology
Wang Y,Bian J,Yao M,Du L,Xu Y,Chang H,Cong H,Wei Y,Xu W,Wang H,Zhang X,Geng X,Yin L
13-0300 was used in Immunocytochemistry-immunofluorescence to indicate that CCL2 may serve as a promising candidate target for inflammatory disorder therapy, including NMOSD.
Mon Apr 17 00:00:00 EDT 2023
Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model.
Frontiers in cellular neuroscience
MacPherson KP,Eidson LN,Houser MC,Weiss BE,Gollihue JL,Herrick MK,de Sousa Rodrigues ME,Sniffen L,Weekman EM,Hamilton AM,Kelly SD,Oliver DL,Yang Y,Chang J,Sampson TR,Norris CM,Tansey MG
13-0300 was used in Immunohistochemistry-frozen tissue to show that selective inhibition of soluble tumor necrosis factor signaling via the biologic XPro1595 modulates the effects of an high in fat and sugar (HFHS) diet in 5xFAD mice on peripheral and central immune profiles including CNS-associated CD8+ T cells, the composition of gut microbiota, and long-term potentiation deficits.
Sun May 12 00:00:00 EDT 2024
Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis.
Scientific reports
Ono G,Kobayakawa K,Saiwai H,Tamaru T,Iura H,Haruta Y,Kitade K,Iida K,Kawaguchi K,Matsumoto Y,Tsuda M,Tamura T,Ozato K,Inoue K,Konno DJ,Maeda T,Okada S,Nakashima Y
13-0300 was used in Immunohistochemistry-immunofluorescence to reveal a mechanism through which migrating macrophages attract astrocytes and affect the pathophysiology and outcome after SCI.
Mon Jul 10 00:00:00 EDT 2023
Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages.
Journal of neuroinflammation
Yin D,Wang C,Qi Y,Wang YC,Hagemann N,Mohamud Yusuf A,Dzyubenko E,Kaltwasser B,Tertel T,Giebel B,Gunzer M,Popa-Wagner A,Doeppner TR,Hermann DM
13-0300 was used in Immunohistochemistry-immunofluorescence to highlight the necessity of rigorous investigations in vascular risk factor models to fully assess the long-term restorative effects of cell-based therapies.
Fri Sep 15 00:00:00 EDT 2023
LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils.
Biomolecules
Filippini A,Salvi V,Dattilo V,Magri C,Castrezzati S,Veerhuis R,Bosisio D,Gennarelli M,Russo I
13-0300 was used in Immunocytochemistry-immunofluorescence to report that LRRK2 kinase activity modulates astrocytic reactivity and functions in the presence of Aβ1-42 deposits and indicate that PD-linked LRRK2 might contribute to AD-related neuroinflammation and pathogenesis.
Mon Feb 06 00:00:00 EST 2023
LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation.
Cells
Mutti V,Carini G,Filippini A,Castrezzati S,Giugno L,Gennarelli M,Russo I
13-0300 was used in Immunohistochemistry to validate LRRK2 kinase modulation as a pharmacological intervention in preclinical models of AD- and PD-related neuroinflammation.
Thu Jul 06 00:00:00 EDT 2023
Protocol for wireless deep brain stimulation in freely behaving mice with infrared light.
STAR protocols
Wu X,Hong G
13-0300 was used in Immunohistochemistry-immunofluorescence to describe the injection of the TRPV1 (transient receptor potential cation channel subfamily V member 1)-expressing viruses and macromolecular infrared nanotransducers for deep brain stimulation (MINDS).
Fri Mar 17 00:00:00 EDT 2023
Drug screening in zebrafish larvae reveals inflammation-related modulators of secondary damage after spinal cord injury in mice.
Theranostics
Oprişoreanu AM,Ryan F,Richmond C,Dzekhtsiarova Y,Carragher NO,Becker T,David S,Becker CG
13-0300 was used in Immunohistochemistry-immunofluorescence to highlight the usefulness of the zebrafish model for rapid screening of drug libraries to identify therapeutics to treat mammalian spinal cord injury.
Wed May 24 00:00:00 EDT 2023
Astrocytic aryl hydrocarbon receptor mediates chronic kidney disease-associated mental disorders involving GLT1 hypofunction and neuronal activity enhancement in the mouse brain.
Glia
Huang YJ,Hung CC,Hsu PC,Lee PY,Tsai YA,Hsin YC,Lee XT,Chou CC,Chen ML,Tarng DC,Lee YH
13-0300 was used in Immunohistochemistry and Immunocytochemistry to conclude that astrocytic AhR plays a crucial role in the CKD-induced disturbance of neuron-astrocyte interaction and mental disorders.
Sat Apr 01 00:00:00 EDT 2023
Astrocytic aryl hydrocarbon receptor mediates chronic kidney disease-associated mental disorders involving GLT1 hypofunction and neuronal activity enhancement in the mouse brain.
Glia
Huang YJ,Hung CC,Hsu PC,Lee PY,Tsai YA,Hsin YC,Lee XT,Chou CC,Chen ML,Tarng DC,Lee YH
13-0300 was used in Immunohistochemistry and Immunocytochemistry to conclude that astrocytic AhR plays a crucial role in the CKD-induced disturbance of neuron-astrocyte interaction and mental disorders.
Sat Apr 01 00:00:00 EDT 2023
Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus.
Cellular and molecular neurobiology
Hou CC,Li D,Berry BC,Zheng S,Carroll RS,Johnson MD,Yang HW
13-0300 was used in Immunohistochemistry to show that heterozygous FOXJ1 mutations are also associated with communicating hydrocephalus in humans and cause communicating hydrocephalus in mice.
Wed Nov 01 00:00:00 EDT 2023
GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming.
Cellular and molecular gastroenterology and hepatology
Duan S,Sawyer TW,Sontz RA,Wieland BA,Diaz AF,Merchant JL
13-0300 was used in Immunoprecipitation to show that GFAP-directed Men1 inactivation exploits glial cell plasticity in favor of neuroendocrine differentiation.
Thu Oct 27 00:00:00 EDT 2022
Aquaporin 4 is not present in normal porcine and human lamina cribrosa.
PloS one
Kimball EC,Quillen S,Pease ME,Keuthan C,Nagalingam A,Zack DJ,Johnson TV,Quigley HA
13-0300 was used in Immunohistochemistry-immunofluorescence to quantify regional aquaporin channel expression in astrocytes of the porcine and human mouse optic nerve (ON).
Mon Jun 20 00:00:00 EDT 2022
Guidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system.
Nature communications
Vilallongue N,Schaeffer J,Hesse AM,Delpech C,Blot B,Paccard A,Plissonnier E,Excoffier B,Couté Y,Belin S,Nawabi H
13-0300 was used in Immunohistochemistry-immunofluorescence to suggest ways to modulate axon guidance of regenerative neurons to achieve circuit repair in adult.
Thu Oct 13 00:00:00 EDT 2022
Stoichiometric Post-Modification of Hydrogel Microparticles Dictates Neural Stem Cell Fate in Microporous Annealed Particle Scaffolds.
Advanced materials (Deerfield Beach, Fla.)
Wilson KL,Pérez SCL,Naffaa MM,Kelly SH,Segura T
13-0300 was used in Cell Culture to study NPC fate inside MAP scaffolds in vitro.
Mon Aug 01 00:00:00 EDT 2022
4D imaging analysis of the aging mouse neural stem cell niche reveals a dramatic loss of progenitor cell dynamism regulated by the RHO-ROCK pathway.
Stem cell reports
Zhao X,Fisher ES,Wang Y,Zuloaga K,Manley L,Temple S
13-0300 was used in Immunohistochemistry to conclude that RHO-ROCK signaling is critical for normal adult NSC and TAP movement and interactions, which are compromised with age, concomitant with the loss of regenerative ability.
Tue Feb 08 00:00:00 EST 2022
Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone.
Fluids and barriers of the CNS
Norton ES,Whaley LA,Ulloa-Navas MJ,García-Tárraga P,Meneses KM,Lara-Velazquez M,Zarco N,Carrano A,Quiñones-Hinojosa A,García-Verdugo JM,Guerrero-Cázares H
13-0300 was used in Immunohistochemistry to investigate the ependymal cell barrier and its derived extracellular matrix (ECM) fractones in the vicinity of a Glioblastoma tumor.
Mon Jul 11 00:00:00 EDT 2022
Potential Variables for Improved Reproducibility of Neuronal Cell Grafts at Stroke Sites.
Cells
Krzyspiak J,Khodakhah K,Hébert JM
13-0300 was used in Immunohistochemistry-immunofluorescence to find that graft size at stroke sites correlates with the size of ischemic damage, host sex (females having graft sizes that correlate with damage), donor cell maturity, and host age, but not with the time of transplant after stroke.
Tue May 17 00:00:00 EDT 2022
MAX: a simple, affordable, and rapid tissue clearing reagent for 3D imaging of wide variety of biological specimens.
Scientific reports
Lee B,Lee JH,Kim DH,Kim ES,Seo BK,Rhyu IJ,Sun W
13-0300 was used in Immunohistochemistry to evaluate MAX to obtain detailed 3-dimensional images of the structure and function of biological specimens.
Mon Nov 14 00:00:00 EST 2022
Intravital Imaging of the Murine Subventricular Zone with Three Photon Microscopy.
Cerebral cortex (New York, N.Y. : 1991)
Sun B,Wang M,Hoerder-Suabedissen A,Xu C,Packer AM,Szele FG
13-0300 was used in Immunohistochemistry to show for the first time 3PM imaging of the SVZ in live mice.
Tue Jul 12 00:00:00 EDT 2022
Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development.
Experimental neurology
Shiu FH,Wong JC,Yamamoto T,Lala T,Purcell RH,Owino S,Zhu D,Van Meir EG,Hall RA,Escayg A
13-0300 was used in Immunohistochemistry-immunofluorescence to show that reduced levels of full length Bai1 is associated with a broader range of clinically relevant phenotypes than previously reported.
Sun May 01 00:00:00 EDT 2022
The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling.
The Journal of biological chemistry
Gayen M,Benoit MR,Fan Q,Hudobenko J,Yan R
13-0300 was used in Immunocytochemistry to suggest that CX3CL1-ICD may have translational potential for neuroprotection in Alzheimer's disease and for disorders resulting from insulin resistance.
Tue Nov 01 00:00:00 EDT 2022
Fluoxetine increases astrocytic glucose uptake and glycolysis in corticosterone-induced depression through restricting GR-TXNIP-GLUT1 Pathway.
Frontiers in pharmacology
Pan SM,Zhou YF,Zuo N,Jiao RQ,Kong LD,Pan Y
13-0300 was used in Immunohistochemistry-immunofluorescence to exhibit that fluoxetine restricts GR-TXNIP-GLUT1 pathway, increasing astrocytic glucose uptake and glycolysis in corticosterone-induced depression.
Sat Sep 17 00:00:00 EDT 2022
Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa.
Neural regeneration research
Zhang HJ,Liu XB,Chen XM,Kong QH,Liu YS,So KF,Chen JS,Xu Y,Mi XS,Tang SB
13-0300 was used in Immunocytochemistry to confirm the ability of lutein to postpone photoreceptor degeneration by reducing reactive gliosis of Müller cells in the retina and exerting anti-inflammatory effects.
Fri Jul 01 00:00:00 EDT 2022
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Nature
Burda JE,O'Shea TM,Ao Y,Suresh KB,Wang S,Bernstein AM,Chandra A,Deverasetty S,Kawaguchi R,Kim JH,McCallum S,Rogers A,Wahane S,Sofroniew MV
13-0300 was used in Immunohistochemistry to show that transcriptional changes associated with astrocyte reactivity are highly heterogeneous and are customized from vast numbers of potential DEGs through context-specific combinatorial transcriptional-regulator interactions.
Wed Jun 01 00:00:00 EDT 2022
Depletion of miR-96 Delays, But Does Not Arrest, Photoreceptor Development in Mice.
Investigative ophthalmology & visual science
Xiang L,Zhang J,Rao FQ,Yang QL,Zeng HY,Huang SH,Xie ZX,Lv JN,Lin D,Chen XJ,Wu KC,Lu F,Huang XF,Chen Q
13-0300 was used in Immunohistochemistry to study the role of miR-96, a member of miR-183C, in photoreceptor development and functionality.
Fri Apr 01 00:00:00 EDT 2022
Neuronal-glial communication perturbations in murine SOD1G93A spinal cord.
Communications biology
MacLean M,López-Díez R,Vasquez C,Gugger PF,Schmidt AM
13-0300 was used in Immunohistochemistry to interrogate cell-intrinsic and inter-cell type perturbations in amyotrophic lateral sclerosis.
Mon Feb 28 00:00:00 EST 2022
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina.
Translational vision science & technology
Danjo Y,Shinozaki Y,Natsubori A,Kubota Y,Kashiwagi K,Tanaka KF,Koizumi S
13-0300 was used in Immunohistochemistry to conclude that the Mlc1 promoter allows us to manipulate gene expression in Müller cells without affecting astrocytes in the retina.
Mon Jan 03 00:00:00 EST 2022
Fibrinogen regulates lesion border-forming reactive astrocyte properties after vascular damage.
Glia
Conforti P,Mezey S,Nath S,Chu YH,Malik SC,Martínez Santamaría JC,Deshpande SS,Pous L,Zieger B,Schachtrup C
13-0300 was used in Immunohistochemistry to identify fibrinogen as a critical trigger for lesion border-forming astrocyte properties in CNS disease.
Fri Jul 01 00:00:00 EDT 2022
Fibrinogen regulates lesion border-forming reactive astrocyte properties after vascular damage.
Glia
Conforti P,Mezey S,Nath S,Chu YH,Malik SC,Martínez Santamaría JC,Deshpande SS,Pous L,Zieger B,Schachtrup C
13-0300 was used in Immunohistochemistry to identify fibrinogen as a critical trigger for lesion border-forming astrocyte properties in CNS disease.
Fri Jul 01 00:00:00 EDT 2022
The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination.
Glia
Suo N,He B,Cui S,Yang Y,Wang M,Yuan Q,Xie X
13-0300 was used in Western Blotting to suggest that deleting or blocking GPR149 might be an intriguing way to promote myelin repair in demyelinating diseases.
Sat Oct 01 00:00:00 EDT 2022
Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death.
Inflammation and regeneration
Yamada H,Kase Y,Okano Y,Kim D,Goto M,Takahashi S,Okano H,Toda M
13-0300 was used in Immunohistochemistry to investigate neuroinflammation and neuronal cell death in the cortex distal to the hematoma injection site, from anterior to posterior region 24 h after SAH injury.
Wed Dec 14 00:00:00 EST 2022
Evaluation of the Cardiometabolic Disorders after Spinal Cord Injury in Mice.
Biology
Ghnenis AB,Jones C,Sefiani A,Douthitt AJ,Reyna AJ,Rutkowski JM,Geoffroy CG
13-0300 was used in Immunohistochemistry to examine the effects of SCI severity on functional recovery and cardiometabolic functions following moderate (50 kdyn) and severe (75 kdyn) contusions in the thoracic-8 (T8) vertebrae in mice using imaging, morphometric, and molecular analyses.
Thu Mar 24 00:00:00 EDT 2022
Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations.
International journal of molecular sciences
Fernández-Serra R,Martínez-Alonso E,Alcázar A,Chioua M,Marco-Contelles J,Martínez-Murillo R,Ramos M,Guinea GV,González-Nieto D
13-0300 was used in Immunohistochemistry to highlight the potential of 2-APB to target spreading depolarization events and their associated inverse hemodynamic changes, which mainly contribute to extension of the area of lesion in cerebrovascular pathologies.
Mon Jul 04 00:00:00 EDT 2022
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia.
Acta neuropathologica communications
Shi H,Yin Z,Koronyo Y,Fuchs DT,Sheyn J,Davis MR,Wilson JW,Margeta MA,Pitts KM,Herron S,Ikezu S,Ikezu T,Graham SL,Gupta VK,Black KL,Mirzaei M,Butovsky O,Koronyo-Hamaoui M
13-0300 was used in Immunohistochemistry-wholemount to identify MGnD microglia in APPSWE/PS1L166P mouse retina.
Thu Sep 08 00:00:00 EDT 2022
Customized blood-brain barrier shuttle peptide to increase AAV9 vector crossing the BBB and augment transduction in the brain.
Biomaterials
Zhang X,Chai Z,Lee Dobbins A,Itano MS,Askew C,Miao Z,Niu H,Samulski RJ,Li C
13-0300 was used in Immunohistochemistry-immunofluorescence to reveal that the PB5-3 peptide effectively increased AAV9 trafficking and transcytosis efficiency in the human BBB model hCMEC/D3 cell line but did not interfere with AAV9 binding to the receptor terminal N-linked galactosylated glycans.
Tue Feb 01 00:00:00 EST 2022
Astrocytes show increased levels of Ero1α in multiple sclerosis and its experimental autoimmune encephalomyelitis animal model.
The European journal of neuroscience
Samtleben S,Mina L,Yap MC,Branton WG,Yousuf MS,Tenorio G,Ballanyi K,Giuliani F,Kerr BJ,Power C,Simmen T
13-0300 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to show that Ero1α induction makes astrocytes vulnerable to oxidative stress in the MS and EAE pathologies.
Sat Oct 01 00:00:00 EDT 2022
Astrocytes show increased levels of Ero1α in multiple sclerosis and its experimental autoimmune encephalomyelitis animal model.
The European journal of neuroscience
Samtleben S,Mina L,Yap MC,Branton WG,Yousuf MS,Tenorio G,Ballanyi K,Giuliani F,Kerr BJ,Power C,Simmen T
13-0300 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to show that Ero1α induction makes astrocytes vulnerable to oxidative stress in the MS and EAE pathologies.
Sat Oct 01 00:00:00 EDT 2022
Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease.
Acta pharmaceutica Sinica. B
Bai P,Mondal P,Bagdasarian FA,Rani N,Liu Y,Gomm A,Tocci DR,Choi SH,Wey HY,Tanzi RE,Zhang C,Wang C
13-0300 was used in Immunohistochemistry to show that HDAC6 may lead to AD by mechanisms that tend to affect brain regions particularly susceptible to AD through an association with amyloid pathology.
Sat Oct 01 00:00:00 EDT 2022
Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion.
International journal of molecular sciences
Lee D,Tomita Y,Miwa Y,Jeong H,Shinojima A,Ban N,Yamaguchi S,Nishioka K,Negishi K,Yoshino J,Kurihara T
13-0300 was used in Immunohistochemistry to find that UCCAO-induced retinal dysfunction was suppressed, pathological gliosis was reduced, retinal NAD+ levels were preserved, and the expression of an antioxidant molecule (nuclear factor erythroid-2-related factor 2; Nrf2) was upregulated by consecutive administration of NMN.
Fri Nov 25 00:00:00 EST 2022
Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders.
Science (New York, N.Y.)
Martin M,Vermeiren S,Bostaille N,Eubelen M,Spitzer D,Vermeersch M,Profaci CP,Pozuelo E,Toussay X,Raman-Nair J,Tebabi P,America M,De Groote A,Sanderson LE,Cabochette P,Germano RFV,Torres D,Boutry S,de Kerchove d'Exaerde A,Bellefroid EJ,Phoenix TN,Devraj K,Lacoste B,Daneman R,Liebner S,Vanhollebeke B
13-0300 was used in Immunocytochemistry-immunofluorescence to reveal that the signaling specificity of Wnt ligands is adjustable and defines a modality to treat CNS disorders by normalizing the BBB.
Fri Feb 18 00:00:00 EST 2022
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy.
Acta neuropathologica communications
Pai B,Tome-Garcia J,Cheng WS,Nudelman G,Beaumont KG,Ghatan S,Panov F,Caballero E,Sarpong K,Marcuse L,Yoo J,Jiang Y,Schaefer A,Akbarian S,Sebra R,Pinto D,Zaslavsky E,Tsankova NM
13-0300 was used in Immunohistochemistry-immunofluorescence to validate a method that simultaneously isolates neuronal (NEUN +), astrocyte (PAX6 + NEUN-), and oligodendroglial progenitor (OPC) (OLIG2 + NEUN-) enriched nuclei populations from non-diseased, fresh-frozen human neocortex and then applied it to characterize the distinct transcriptomes of such populations isolated from electrode-mapped temporal lobe epilepsy (TLE) surgical samples.
Sun Oct 23 00:00:00 EDT 2022
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.
The Journal of biological chemistry
Hirata T,Kobayashi A,Furuse T,Yamada I,Tamura M,Tomita H,Tokoro Y,Ninomiya A,Fujihara Y,Ikawa M,Maeda Y,Murakami Y,Kizuka Y,Kinoshita T
13-0300 was used in Immunohistochemistry, Western Blot to investigate physiological and pathological roles of GPI-GalNAc in mice.
Tue Mar 01 00:00:00 EST 2022
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.
The Journal of biological chemistry
Hirata T,Kobayashi A,Furuse T,Yamada I,Tamura M,Tomita H,Tokoro Y,Ninomiya A,Fujihara Y,Ikawa M,Maeda Y,Murakami Y,Kizuka Y,Kinoshita T
13-0300 was used in Immunohistochemistry, Western Blot to investigate physiological and pathological roles of GPI-GalNAc in mice.
Tue Mar 01 00:00:00 EST 2022
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
ACS chemical neuroscience
Permanne B,Sand A,Ousson S,Nény M,Hantson J,Schubert R,Wiessner C,Quattropani A,Beher D
13-0300 was used in Inhibition Assays to provide a strong rationale for the development of OGA inhibitors as disease-modifying agents in both tauopathies and α-synucleinopathies.
Wed Apr 20 00:00:00 EDT 2022
Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development.
Biology open
Gillnäs S,Gallini R,He L,Betsholtz C,Andrae J
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate if platelet-derived growth factor C/PDGFRα signalling is a critical component in the network of molecular and cellular interactions that take place between the developing meninges and neural tissues, and which are required to build a fully functioning cerebellum.
Mon Aug 15 00:00:00 EDT 2022
Osteopenia in a Mouse Model of Spinal Cord Injury: Effects of Age, Sex and Motor Function.
Biology
Hook MA,Falck A,Dundumulla R,Terminel M,Cunningham R,Sefiani A,Callaway K,Gaddy D,Geoffroy CG
13-0300 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, In Vitro Assay to show that while partial weight-bearing does not stabilize/reverse bone loss in humans, our data suggest that therapies that simulate complete loading may be effective after SCI.
Wed Jan 26 00:00:00 EST 2022
In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system.
Science advances
Allen JK,Sutherland TC,Prater AR,Geoffroy CG,Pellois JP
13-0300 was used in Immunohistochemistry-immunofluorescence to indicate that the delivery peptides mediate efficient endosomal leakage and cytosolic escape in cells that have endocytosed Cre.
Fri Sep 30 00:00:00 EDT 2022
A Whole-Genome Sequencing Study Implicates GRAMD1B in Multiple Sclerosis Susceptibility.
Genes
Esposito F,Osiceanu AM,Sorosina M,Ottoboni L,Bollman B,Santoro S,Bettegazzi B,Zauli A,Clarelli F,Mascia E,Calabria A,Zacchetti D,Capra R,Ferrari M,Provero P,Lazarevic D,Cittaro D,Carrera P,Patsopoulos N,Toniolo D,Sadovnick AD,Martino G,De Jager PL,Comi G,Stupka E,Vilariño-Güell C,Piccio L,Martinelli Boneschi F
13-0300 was used in Immunohistochemistry to demonstrate that GRAMD1B, a gene with unknown function in the central nervous system (CNS), is expressed by several cell types, including astrocytes, microglia and neurons as well as by peripheral monocytes and macrophages.
Fri Dec 16 00:00:00 EST 2022
Loss of mouse Stmn2 function causes motor neuropathy.
Neuron
Guerra San Juan I,Nash LA,Smith KS,Leyton-Jaimes MF,Qian M,Klim JR,Limone F,Dorr AB,Couto A,Pintacuda G,Joseph BJ,Whisenant DE,Noble C,Melnik V,Potter D,Holmes A,Burberry A,Verhage M,Eggan K
13-0300 was used in Immunocytochemistry to demonstrate that disrupting the ortholog of a single TDP43-regulated RNA is sufficient to cause substantial motor dysfunction, indicating that disruption of TDP43 function is likely a contributor to ALS.
Wed May 18 00:00:00 EDT 2022
Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus.
Frontiers in aging neuroscience
Nick H,Fenik P,Zhu Y,Veasey S
13-0300 was used in Immunohistochemistry-immunofluorescence to demonstrate that HCRT promotes amyloid-β accumulation and loss of cholinergic projections in the hippocampus, yet does not influence locus coeruleus neuron response to CFS.
Sat Mar 11 00:00:00 EST 2023
The Role of Interferon Regulatory Factor 1 in Regulating Microglial Activation and Retinal Inflammation.
International journal of molecular sciences
Yang X,Diaz V,Huang H
13-0300 was used in Immunohistochemistry-immunofluorescence to suggest that IRF1 plays a vital role in regulating microglial activation and retinal inflammation and, therefore, may be targeted for treating inflammatory and degenerative retinal diseases.
Thu Nov 24 00:00:00 EST 2022
Long-term maturation of human cortical organoids matches key early postnatal transitions.
Nature neuroscience
Gordon A,Yoon SJ,Tran SS,Makinson CD,Park JY,Andersen J,Valencia AM,Horvath S,Xiao X,Huguenard JR,Pașca SP,Geschwind DH
13-0300 was used in Immunohistochemistry to suggest that important components of an intrinsic in vivo developmental program persist in vitro.
Mon Mar 01 00:00:00 EST 2021
Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Nature neuroscience
Merlini M,Rafalski VA,Ma K,Kim KY,Bushong EA,Rios Coronado PE,Yan Z,Mendiola AS,Sozmen EG,Ryu JK,Haberl MG,Madany M,Sampson DN,Petersen MA,Bardehle S,Tognatta R,Dean T,Acevedo RM,Cabriga B,Thomas R,Coughlin SR,Ellisman MH,Palop JJ,Akassoglou K
13-0300 was used in Immunohistochemistry to conclude that Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases.
Fri Jan 01 00:00:00 EST 2021
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
Neuron
Han S,Okawa S,Wilkinson GA,Ghazale H,Adnani L,Dixit R,Tavares L,Faisal I,Brooks MJ,Cortay V,Zinyk D,Sivitilli A,Li S,Malik F,Ilnytskyy Y,Angarica VE,Gao J,Chinchalongporn V,Oproescu AM,Vasan L,Touahri Y,David LA,Raharjo E,Kim JW,Wu W,Rahmani W,Chan JA,Kovalchuk I,Attisano L,Kurrasch D,Dehay C,Swaroop A,Castro DS,Biernaskie J,Del Sol A,Schuurmans C
13-0300 was used in Immunohistochemistry to show that Neurog2 and Ascl1 proneural genes regulate cortical progenitor cell differentiation through crossrepressive interactions to sustain neurogenic continuity in a lissencephalic rodent brain.
Wed Sep 15 00:00:00 EDT 2021
Small extracellular vesicles obtained from hypoxic mesenchymal stromal cells have unique characteristics that promote cerebral angiogenesis, brain remodeling and neurological recovery after focal cerebral ischemia in mice.
Basic research in cardiology
Gregorius J,Wang C,Stambouli O,Hussner T,Qi Y,Tertel T,Börger V,Mohamud Yusuf A,Hagemann N,Yin D,Dittrich R,Mouloud Y,Mairinger FD,Magraoui FE,Popa-Wagner A,Kleinschnitz C,Doeppner TR,Gunzer M,Meyer HE,Giebel B,Hermann DM
13-0300 was used in Immunohistochemistry to evaluate the effects of mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) on the proliferation, migration, and tube formation of human cerebral microvascular endothelial cells (hCMEC/D3).
Tue Jun 08 00:00:00 EDT 2021
Inhibitory control in neuronal networks relies on the extracellular matrix integrity.
Cellular and molecular life sciences : CMLS
Dzyubenko E,Fleischer M,Manrique-Castano D,Borbor M,Kleinschnitz C,Faissner A,Hermann DM
13-0300 was used in Immunohistochemistry to study the role of the extracellular matrix in sustaining the excitation-inhibition balance in neuronal networks.
Thu Jul 01 00:00:00 EDT 2021
Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury.
Cellular and molecular life sciences : CMLS
Loy K,Fourneau J,Meng N,Denecke C,Locatelli G,Bareyre FM
13-0300 was used in Immunohistochemistry to identify Sema7A as a critical regulator of serotonergic circuit formation in the injured spinal cord.
Mon Mar 01 00:00:00 EST 2021
Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.
Glia
Muraleedharan A,Rotem-Dai N,Strominger I,Anto NP,Isakov N,Monsonego A,Livneh E
13-0300 was used in Immunohistochemistry to identify PKCη as a regulator of neuroinflammation in AD.
Mon Mar 01 00:00:00 EST 2021
Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes.
Glia
Muraleedharan A,Rotem-Dai N,Strominger I,Anto NP,Isakov N,Monsonego A,Livneh E
13-0300 was used in Immunohistochemistry to identify PKCη as a regulator of neuroinflammation in AD.
Mon Mar 01 00:00:00 EST 2021
Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy.
Neurobiology of stress
Woodburn SC,Bollinger JL,Wohleb ES
13-0300 was used in Immunohistochemistry to show prefrontal cortex dysfunction is promoted by microglia-mediated neuronal remodeling, astrocyte dystrophy, and synapse loss.
Sat May 01 00:00:00 EDT 2021
Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Sleep
Owen JE,Zhu Y,Fenik P,Zhan G,Bell P,Liu C,Veasey S
13-0300 was used in Immunohistochemistry to demonstrate for the first time that CSS can induce lasting, significant neural injury consistent with some, but not all, features of late onset AD.
Fri Aug 13 00:00:00 EDT 2021
Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Yang CY,Hung YC,Cheng KH,Ling P,Hsu KS
13-0300 was used in Immunohistochemistry to investigate the pathogenic origin of the autistic features of Coiled-coil and C2 domain containing 1A deficiency.
Thu Jul 01 00:00:00 EDT 2021
Serotonin Plays a Key Role in the Development of Opioid-Induced Hyperalgesia in Mice.
The journal of pain
Sasaki M,Kamiya Y,Bamba K,Onishi T,Matsuda K,Kohno T,Kurabe M,Furutani K,Yanagimura H
13-0300 was used in Immunohistochemistry to investigate the effect of serotonin inhibition by the 5-HT3 receptor antagonist, ondansetron, as well as serotonin deprivation via its synthesis inhibitor para-chlorophenylalanine, on mouse opioid-induced hyperalgesia models, with particular focus on astrocyte activation.
Tue Jun 01 00:00:00 EDT 2021
Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice.
The Journal of pharmacology and experimental therapeutics
Pérez-Osorio IN,Espinosa A,Giraldo Velázquez M,Padilla P,Bárcena B,Fragoso G,Jung-Cook H,Besedovsky H,Meneses G,Sciutto Conde EL
13-0300 was used in Immunohistochemistry to explain some of the evidence shown in a previous work in which dexamethasone controls neuroinflammation in a murine stroke model and can be used to propose alternative treatments for neuroinflammatory diseases.
Wed Sep 01 00:00:00 EDT 2021
20-HETE Participates in Intracerebral Hemorrhage-Induced Acute Injury by Promoting Cell Ferroptosis.
Frontiers in neurology
Han R,Wan J,Han X,Ren H,Falck JR,Munnuri S,Yang ZJ,Koehler RC
13-0300 was used in Western Blotting to indicate that 20-HETE contributes to ICH-induced acute brain injury in part by activating ferroptosis pathways, thereby providing an upstream target for inhibiting ferroptosis.
Thu May 12 00:00:00 EDT 2022
Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion.
BioMed research international
Lee D,Nakai A,Miwa Y,Tomita Y,Serizawa N,Katada Y,Hatanaka Y,Tsubota K,Negishi K,Kurihara T
13-0300 was used in Immunohistochemistry to further examine the mechanims behind the ocular pathologic process by unilateral common carotid artery occlusion.
Fri Jan 14 00:00:00 EST 2022
Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury.
Acta neuropathologica communications
Mallah K,Couch C,Alshareef M,Borucki D,Yang X,Alawieh A,Tomlinson S
13-0300 was used in Immunohistochemistry to demonstrate continued complement mediated neuroinflammation at extended chronic time points after traumatic brain injury, and extend the potential treatment window for complement inhibition, using - immunofluorescence (IHC-IF).
Tue Apr 20 00:00:00 EDT 2021
Adipose mesenchymal stem cells-secreted extracellular vesicles containing microRNA-192 delays diabetic retinopathy by targeting ITGA1.
Journal of cellular physiology
Gu C,Zhang H,Gao Y
13-0300 was used in Immunohistochemistry-immunofluorescence to establish that miR-192 released by Evs from MSCs could delay the events of the inflammatory response and angiogenesis in Diabetic retinopathy (DR) and may represent a possible therapeutic approach for the treatment of DR.
Thu Jul 01 00:00:00 EDT 2021
Hippocampal-Dependent Cognitive Dysfunction following Repeated Diffuse Rotational Brain Injury in Male and Female Mice.
Journal of neurotrauma
Tucker LB,Fu AH,McCabe JT
13-0300 was used in Immunohistochemistry to study in both male and female mice the hippocampal-dependent learning and memory deficits resulting from traumatic brain injury.
Tue Jun 01 00:00:00 EDT 2021
The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism.
Cell reports
Heiss CN,Mannerås-Holm L,Lee YS,Serrano-Lobo J,Håkansson Gladh A,Seeley RJ,Drucker DJ,Bäckhed F,Olofsson LE
13-0300 was used in Immunohistochemistry to show that wild-type (WT) mice with depleted gut microbiota, i.e., germ-free (GF) and antibiotic-treated mice, have elevated levels of glucagon-like peptide-1 (GLP-1), are protected against diet-induced hypothalamic inflammation, and have enhanced leptin sensitivity when fed a Western diet.
Tue May 25 00:00:00 EDT 2021
Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions.
Neuron
Girskis KM,Stergachis AB,DeGennaro EM,Doan RN,Qian X,Johnson MB,Wang PP,Sejourne GM,Nagy MA,Pollina EA,Sousa AMM,Shin T,Kenny CJ,Scotellaro JL,Debo BM,Gonzalez DM,Rento LM,Yeh RC,Song JHT,Beaudin M,Fan J,Kharchenko PV,Sestan N,Greenberg ME,Walsh CA
13-0300 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot to establish HARs as key components in rewiring human-specific neurodevelopmental gene regulatory programs.
Wed Oct 20 00:00:00 EDT 2021
Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains.
Molecular neurodegeneration
Sharoar MG,Palko S,Ge Y,Saido TC,Yan R
13-0300 was used in Immunohistochemistry to indicate that lysosomal functions are impaired by being entrapped in DNs early during plaque growth, and this may viciously facilitate growth of amyloid plaques.
Fri Jul 02 00:00:00 EDT 2021
Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner.
Journal of neuroinflammation
MacLean M,Juranek J,Cuddapah S,López-Díez R,Ruiz HH,Hu J,Frye L,Li H,Gugger PF,Schmidt AM
13-0300 was used in Immunohistochemistry to understand the role of microglia and advanced glycation end-product receptors in the pathogenesis of amyotrophic lateral sclerosis.
Tue Jun 15 00:00:00 EDT 2021
3D spheroids of human placenta-derived mesenchymal stem cells attenuate spinal cord injury in mice.
Cell death & disease
Deng J,Li M,Meng F,Liu Z,Wang S,Zhang Y,Li M,Li Z,Zhang L,Tang P
13-0300 was used in Immunohistochemistry to suggest that 3D-HPMSCs may hold great potential for the treatment of SCI.
Mon Nov 22 00:00:00 EST 2021
Luteolin delays photoreceptor degeneration in a mouse model of retinitis pigmentosa.
Neural regeneration research
Liu XB,Liu F,Liang YY,Yin G,Zhang HJ,Mi XS,Zhang ZJ,So KF,Li A,Xu Y
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate whether luteolin exhibits neuroprotective effects on rod cells in rd10 mice, a slow photoreceptor-degenerative model of retinitis pigmentosa.
Fri Oct 01 00:00:00 EDT 2021
Ndufs4 ablation decreases synaptophysin expression in hippocampus.
Scientific reports
Shil SK,Kagawa Y,Umaru BA,Nanto-Hara F,Miyazaki H,Yamamoto Y,Kobayashi S,Suzuki C,Abe T,Owada Y
13-0300 was used in Western Blot, Immunohistochemistry to suggest that Ndufs4-modulated mitochondrial activity may be involved in neuroplasticity via regulating synaptophysin expression.
Wed May 26 00:00:00 EDT 2021
Ndufs4 ablation decreases synaptophysin expression in hippocampus.
Scientific reports
Shil SK,Kagawa Y,Umaru BA,Nanto-Hara F,Miyazaki H,Yamamoto Y,Kobayashi S,Suzuki C,Abe T,Owada Y
13-0300 was used in Western Blot, Immunohistochemistry to suggest that Ndufs4-modulated mitochondrial activity may be involved in neuroplasticity via regulating synaptophysin expression.
Wed May 26 00:00:00 EDT 2021
The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma.
PloS one
Kimball E,Schaub J,Quillen S,Keuthan C,Pease ME,Korneva A,Quigley H
13-0300 was used in Immunocytochemistry to show that the minimal presence of AQP4 in UON may be a vital aspect of the regionally specific phenotype of astrocytes in the mouse optic nerve head.
Mon Jul 19 00:00:00 EDT 2021
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture.
Nature communications
Lattke M,Goldstone R,Ellis JK,Boeing S,Jurado-Arjona J,Marichal N,MacRae JI,Berninger B,Guillemot F
13-0300 was used in Immunohistochemistry to conclude that extrinsic signals orchestrate the expression of multiple intrinsic regulators, which in turn induce in a modular manner the transcriptional and chromatin changes underlying astrocyte maturation.
Thu Jul 15 00:00:00 EDT 2021
Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages.
Frontiers in neuroscience
Zhang M,Zhong L,Han X,Xiong G,Xu D,Zhang S,Cheng H,Chiu K,Xu Y
13-0300 was used in Immunocytochemistry to conclude that the timeline of the degenerative processes in the retina and the brain is similar, supporting the use of non-invasive methods to test the retinal structure and function to reflect changes in the brain for early AD diagnosis.
Tue Aug 10 00:00:00 EDT 2021
Mitochondrial Deficits With Neural and Social Damage in Early-Stage Alzheimer's Disease Model Mice.
Frontiers in aging neuroscience
Misrani A,Tabassum S,Huo Q,Tabassum S,Jiang J,Ahmed A,Chen X,Zhou J,Zhang J,Liu S,Feng X,Long C,Yang L
13-0300 was used in Western Blotting to suggest that abnormal mitochondrial dynamics, which worsen with disease progression, could be a biomarker of early-stage AD.
Tue Dec 28 00:00:00 EST 2021
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
Glia
Tanaka M,Shigetomi E,Parajuli B,Nagatomo H,Shinozaki Y,Hirayama Y,Saito K,Kubota Y,Danjo Y,Lee JH,Kim SK,Nabekura J,Koizumi S
13-0300 was used in Immunocytochemistry to reveal that A2B receptor is critical for down-regulation of mGluR5 in astrocytes, contributing to termination of excess synaptogenesis during development.
Mon Nov 01 00:00:00 EDT 2021
Sigma-1 Receptor is a Pharmacological Target to Promote Neuroprotection in the SOD1G93A ALS Mice.
Frontiers in pharmacology
Gaja-Capdevila N,Hernández N,Navarro X,Herrando-Grabulosa M
13-0300 was used in Immunohistochemistry to show that PRE-084, as well as BD1063 treatment was able to preserve neuromuscular function of the hindlimbs and increased the number of surviving MNs in the treated female SOD1G93A mice.
Tue Dec 28 00:00:00 EST 2021
Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment.
Frontiers in aging neuroscience
Li M,Kitamura A,Beverley J,Koudelka J,Duncombe J,Lennen R,Jansen MA,Marshall I,Platt B,Wiegand UK,Carare RO,Kalaria RN,Iliff JJ,Horsburgh K
13-0300 was used in Immunohistochemistry to test a hypothesis that glymphatic function would be impaired in a bilateral common carotid stenosis model and exacerbated in the presence of amyloid-β protein.
Sat Jul 15 00:00:00 EDT 2023
Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Science advances
Shariq M,Sahasrabuddhe V,Krishna S,Radha S,Bellampalli R,Dwivedi A,Cheramangalam R,Reizis B,Hébert J,Ghosh HS
13-0300 was used in Western Blotting to provide evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify Tcf4 as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential.
Sat May 01 00:00:00 EDT 2021
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
JCI insight
Sano F,Shigetomi E,Shinozaki Y,Tsuzukiyama H,Saito K,Mikoshiba K,Horiuchi H,Cheung DL,Nabekura J,Sugita K,Aihara M,Koizumi S
13-0300 was used in Immunohistochemistry to show that temporally distinct activation profiles of microglia and astrocytes collaboratively contributed to epileptogenesis in a drug-induced status epilepticus model.
Mon May 10 00:00:00 EDT 2021
Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture.
Mediators of inflammation
Ritter K,Jung K,Dolderer C,Appel D,Oswald CC,Ritz U,Schäfer MKE
13-0300 was used in Immunohistochemistry to report early reciprocal impairments of brain tissue maintenance, behavioral recovery, and bone repair gene expression.
Mon Sep 20 00:00:00 EDT 2021
BASP1 labels neural stem cells in the neurogenic niches of mammalian brain.
Scientific reports
Manganas LN,Durá I,Osenberg S,Semerci F,Tosun M,Mishra R,Parkitny L,Encinas JM,Maletic-Savatic M
13-0300 was used in Immunohistochemistry to identify the specific components involved in The mechanisms responsible for determining neural stem cell fate are numerous and complex.
Wed Mar 10 00:00:00 EST 2021
An inducible glycogen synthase-1 knockout halts but does not reverse Lafora disease progression in mice.
The Journal of biological chemistry
Nitschke S,Chown EE,Zhao X,Gabrielian S,Petković S,Guisso DR,Perri AM,Wang P,Ahonen S,Nitschke F,Minassian BA
13-0300 was used in Immunohistochemistry to suggest that endogenous mechanisms to clear brain LBs are absent or, possibly, compromised in laforin-deficient murine LD.
Fri Aug 20 00:00:00 EDT 2021
Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models.
Molecular neurodegeneration
Chen M,Chen Y,Huo Q,Wang L,Tan S,Misrani A,Jiang J,Chen J,Chen S,Zhang J,Tabassum S,Wang J,Chen X,Long C,Yang L
13-0300 was used in Immunohistochemistry to elucidate the mechanistic relationships between the electrophysiological, biochemical and behavioral in olfactory impairment in rodent models of Alzheimer's disease.
Thu Mar 04 00:00:00 EST 2021
Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.
Cell reports
Wei H,Wu X,You Y,Duran RC,Zheng Y,Narayanan KL,Hai B,Li X,Tallapragada N,Prajapati TJ,Kim DH,Deneen B,Cao QL,Wu JQ
13-0300 was used in Immunohistochemistry, Immunocytochemistry to study the molecular changes in the injury environment and the astrocyte-specific responses by astrocyte purification from injured spinal cords from acute to chronic stages.
Tue Feb 02 00:00:00 EST 2021
Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis.
Cell reports
Wei H,Wu X,You Y,Duran RC,Zheng Y,Narayanan KL,Hai B,Li X,Tallapragada N,Prajapati TJ,Kim DH,Deneen B,Cao QL,Wu JQ
13-0300 was used in Immunohistochemistry, Immunocytochemistry to study the molecular changes in the injury environment and the astrocyte-specific responses by astrocyte purification from injured spinal cords from acute to chronic stages.
Tue Feb 02 00:00:00 EST 2021
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation.
Frontiers in immunology
Linnerbauer M,Lößlein L,Farrenkopf D,Vandrey O,Tsaktanis T,Naumann U,Rothhammer V
13-0300 was used in Immunohistochemistry to demonstrate in vivo that astrocyte-derived pleiotrophin is critical for the recovery phase of autoimmune encephalomyelitis and limits chronic CNS inflammation.
Mon Feb 14 00:00:00 EST 2022
Integrated Bioinformatics Analysis of Potential mRNA and miRNA Regulatory Networks in Mice With Ischemic Stroke Treated by Electroacupuncture.
Frontiers in neurology
Wu C,Zhao L,Li X,Xu Y,Guo H,Huang Z,Wang Q,Liu H,Chen D,Zhu M
13-0300 was used in Immunocytochemistry-immunofluorescence to investigate electropuncture treatment in mice on mRNA and miRNA networks.
Wed Sep 29 00:00:00 EDT 2021
TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression.
Cells
Kwon O,Yang H,Kim SC,Kim J,Sim J,Lee J,Hwang EM,Shim S,Park JY
13-0300 was used in Immunohistochemistry to study the expression patterns of TWIK-1 proteins in the brain.
Thu Oct 14 00:00:00 EDT 2021
Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion.
International journal of molecular sciences
Lee D,Tomita Y,Jeong H,Miwa Y,Tsubota K,Negishi K,Kurihara T
13-0300 was used in Immunohistochemistry (Frozen) to study systemic and retinal alterations due to cardiovascular diseases (CVDs) by treating pemafibrate in a new murine model of retinal ischemia caused by CVDs.
Mon Aug 30 00:00:00 EDT 2021
Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries.
eLife
Olivera GC,Ross EC,Peuckert C,Barragan A
13-0300 was used in Immunohistochemistry-immunofluorescence to reveal that the initial passage of T. gondii to the central nervous system occurs principally across cortical capillaries and that the integrity of the microvascular BBB restricts parasite transit, which conversely is exacerbated by the inflammatory response.
Wed Dec 08 00:00:00 EST 2021
Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum.
Stem cell reviews and reports
Takase H,Hamanaka G,Ohtomo R,Park JH,Chung KK,Gelman IH,Kim KW,Lok J,Lo EH,Arai K
13-0300 was used in Immunohistochemistry to suggest that A-kinase Anchor Protein 12 signaling may be required for postnatal glial formation in the corpus callosum through cell- and non-cell autonomous mechanisms.
Sun Aug 01 00:00:00 EDT 2021
Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice.
Acta neuropathologica communications
Wu Y,Wu H,Zeng J,Pluimer B,Dong S,Xie X,Guo X,Ge T,Liang X,Feng S,Yan Y,Chen JF,Sta Maria N,Ma Q,Gomez-Pinilla F,Zhao Z
13-0300 was used in Immunohistochemistry to demonstrate that microvascular injury plays a key role in the pathogenesis of Alzheimer's disease after mTBI.
Fri Apr 23 00:00:00 EDT 2021
Retinal dysfunction induced in a mouse model of unilateral common carotid artery occlusion.
PeerJ
Lee D,Jeong H,Miwa Y,Shinojima A,Katada Y,Tsubota K,Kurihara T
13-0300 was used in Immunohistochemistry to examine retinal functional changes as well as acute retinal ischemic alterations such as retinal thinning, gliosis and cell death after unilateral common carotid artery occlusion.
Sun Apr 24 00:00:00 EDT 2022
Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength.
eLife
Li Y,Ritchie EM,Steinke CL,Qi C,Chen L,Zheng B,Jin Y
13-0300 was used in Immunocytochemistry to investigate two MAP3Ks, MKK4 and MKK7, in cerebellar Purkinje cells using loss- and gain-of function mouse models.
Thu Jan 21 00:00:00 EST 2021
3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics.
Nature communications
Shin H,Jeong S,Lee JH,Sun W,Choi N,Cho IJ
13-0300 was used in Immunocytochemistry to present a 3D high-density multifunctional MEA with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues.
Thu Jan 21 00:00:00 EST 2021
Analysing Intercellular Communication in Astrocytic Networks Using "Astral".
Frontiers in cellular neuroscience
Dzyubenko E,Prazuch W,Pillath-Eilers M,Polanska J,Hermann DM
13-0300 was used in Immunocytochemistry to indicate the necessity for systematic investigation of astrocyte-neuronal interactions at the network level.
Sat Jul 03 00:00:00 EDT 2021
Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes.
Glia
Ben Haim L,Schirmer L,Zulji A,Sabeur K,Tiret B,Ribon M,Chang S,Lamers WH,Boillée S,Chaumeil MM,Rowitch DH
13-0300 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry (Frozen) to provide evidence towards OL-encoded GS function in spinal cord sensorimotor axis, which is dysregulated in chronic neurological diseases.
Wed Dec 01 00:00:00 EST 2021
Evidence for glutamine synthetase function in mouse spinal cord oligodendrocytes.
Glia
Ben Haim L,Schirmer L,Zulji A,Sabeur K,Tiret B,Ribon M,Chang S,Lamers WH,Boillée S,Chaumeil MM,Rowitch DH
13-0300 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry (Frozen) to provide evidence towards OL-encoded GS function in spinal cord sensorimotor axis, which is dysregulated in chronic neurological diseases.
Wed Dec 01 00:00:00 EST 2021
Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord.
The Journal of experimental medicine
Milich LM,Choi JS,Ryan C,Cerqueira SR,Benavides S,Yahn SL,Tsoulfas P,Lee JK
13-0300 was used in Immunohistochemistry to provide novel mechanistic insight into the pathobiology of not only spinal cord injury but also other traumatic disorders of the CNS.
Mon Aug 02 00:00:00 EDT 2021
AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment.
Nature
Lammert CR,Frost EL,Bellinger CE,Bolte AC,McKee CA,Hurt ME,Paysour MJ,Ennerfelt HE,Lukens JR
13-0300 was used in Immunocytochemistry to identify the inflammasome as a crucial player in establishing a properly formed CNS through its role in the removal of genetically compromised cells.
Wed Apr 01 00:00:00 EDT 2020
Microglia-organized scar-free spinal cord repair in neonatal mice.
Nature
Li Y,He X,Kawaguchi R,Zhang Y,Wang Q,Monavarfeshani A,Yang Z,Chen B,Shi Z,Meng H,Zhou S,Zhu J,Jacobi A,Swarup V,Popovich PG,Geschwind DH,He Z
13-0300 was used in Immunohistochemistry to show that a crush injury to the spinal cord in neonatal mice leads to scar-free healing that permits the growth of long projecting axons through the lesion.
Sun Nov 01 00:00:00 EDT 2020
Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.
Cell
Huang W,Bhaduri A,Velmeshev D,Wang S,Wang L,Rottkamp CA,Alvarez-Buylla A,Rowitch DH,Kriegstein AR
13-0300 was used in Immunohistochemistry to indicate properties of OPC derivation, proliferation, and dispersion important for human white matter expansion and myelination.
Thu Aug 06 00:00:00 EDT 2020
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
Cell
Nguyen PT,Dorman LC,Pan S,Vainchtein ID,Han RT,Nakao-Inoue H,Taloma SE,Barron JJ,Molofsky AB,Kheirbek MA,Molofsky AV
13-0300 was used in Flow Cytometry to study a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.
Thu Jul 23 00:00:00 EDT 2020
Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
Neuron
Chavali M,Ulloa-Navas MJ,Pérez-Borredá P,Garcia-Verdugo JM,McQuillen PS,Huang EJ,Rowitch DH
13-0300 was used in Immunohistochemistry to report that oligodendrocyte precursor cells (OPCs) contact sprouting endothelial tip cells in mouse, ferret, and human neonatal white matter.
Wed Dec 23 00:00:00 EST 2020
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Acta neuropathologica
Cignarella F,Filipello F,Bollman B,Cantoni C,Locca A,Mikesell R,Manis M,Ibrahim A,Deng L,Benitez BA,Cruchaga C,Licastro D,Mihindukulasuriya K,Harari O,Buckland M,Holtzman DM,Rosenthal A,Schwabe T,Tassi I,Piccio L
13-0300 was used in Immunohistochemistry-immunofluorescence to demonstrate that TREM2 was highly expressed on myelin-laden phagocytes in active demyelinating lesions in the CNS of subjects with multiple sclerosis.
Thu Oct 01 00:00:00 EDT 2020
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.
Brain : a journal of neurology
Koronyo-Hamaoui M,Sheyn J,Hayden EY,Li S,Fuchs DT,Regis GC,Lopes DHJ,Black KL,Bernstein KE,Teplow DB,Fuchs S,Koronyo Y,Rentsendorj A
13-0300 was used in Flow cytometry/Cell sorting to explore the impact of selective and transient angiotensin-converting enzyme overexpression on macrophage behaviour and the relative contribution of bone marrow-derived ACE10 macrophages, but not microglia, in attenuating disease progression.
Wed Jan 01 00:00:00 EST 2020
Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.
Cancer immunology research
Hoffmann D,Dvorakova T,Stroobant V,Bouzin C,Daumerie A,Solvay M,Klaessens S,Letellier MC,Renauld JC,van Baren N,Lelotte J,Marbaix E,Van den Eynde BJ
13-0300 was used in Immunohistochemistry-immunofluorescence to develop novel tryptophan 2,3-dioxygenase(TDO)-specific monoclonal antibodies and confirm the expression of TDO in the majority of human cancers.
Wed Jan 01 00:00:00 EST 2020
Parallels between retinal and brain pathology and response to immunotherapy in old, late-stage Alzheimer's disease mouse models.
Aging cell
Doustar J,Rentsendorj A,Torbati T,Regis GC,Fuchs DT,Sheyn J,Mirzaei N,Graham SL,Shah PK,Mastali M,Van Eyk JE,Black KL,Gupta VK,Mirzaei M,Koronyo Y,Koronyo-Hamaoui M
13-0300 was used in Immunohistochemistry to explore the link between retinal and cerebral AD-related biomarkers, including response to GA immunization, in cohorts of old, late-stage ADtg mice.
Wed Oct 14 00:00:00 EDT 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
13-0300 was used in Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
13-0300 was used in Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice.
Translational stroke research
de Carvalho TS,Sanchez-Mendoza EH,Nascentes Melo LM,Schultz Moreira AR,Sardari M,Dzyubenko E,Kleinschnitz C,Hermann DM
13-0300 was used in Immunohistochemistry to study the role of undernutrition in focal cerebral ischemia.
Sat Feb 01 00:00:00 EST 2020
Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Butkovich LM,Houser MC,Chalermpalanupap T,Porter-Stransky KA,Iannitelli AF,Boles JS,Lloyd GM,Coomes AS,Eidson LN,De Sousa Rodrigues ME,Oliver DL,Kelly SD,Chang J,Bengoa-Vergniory N,Wade-Martins R,Giasson BI,Joers V,Weinshenker D,Tansey MG
13-0300 was used in Immunohistochemistry-immunofluorescence to report a novel transgenic mouse expressing human wild-type asyn under control of the noradrenergic-specific dopamine β-hydroxylase promoter (DBH-hSNCA).
Wed Sep 23 00:00:00 EDT 2020
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dodge JC,Jensen EH,Yu J,Sardi SP,Bialas AR,Taksir TV,Bangari DS,Shihabuddin LS
13-0300 was used in Immunohistochemistry to show that cholesterol ester (CE) and triacylglycerol levels are elevated several-fold in the spinal cord GM of male sporadic ALS patients.
Wed Nov 18 00:00:00 EST 2020
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dodge JC,Jensen EH,Yu J,Sardi SP,Bialas AR,Taksir TV,Bangari DS,Shihabuddin LS
13-0300 was used in Immunohistochemistry to show that cholesterol ester (CE) and triacylglycerol levels are elevated several-fold in the spinal cord GM of male sporadic ALS patients.
Wed Nov 18 00:00:00 EST 2020
Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke.
Frontiers in molecular neuroscience
Ge H,Zhang C,Yang Y,Chen W,Zhong J,Fang X,Jiang X,Tan L,Zou Y,Hu R,Chen Y,Feng H
13-0300 was used in Immunohistochemistry to indicate that administration of 70 mg/kg and 100 mg/kg enhanced functional recovery by virtue of decreasing infarct volume.
Wed Feb 10 00:00:00 EST 2021
Therapeutic Role of Neuregulin 1 Type III in SOD1-Linked Amyotrophic Lateral Sclerosis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Mòdol-Caballero G,García-Lareu B,Verdés S,Ariza L,Sánchez-Brualla I,Brocard F,Bosch A,Navarro X,Herrando-Grabulosa M
13-0300 was used in Immunohistochemistry to indicate that increasing NRG1-III at the spinal cord is a promising approach for promoting MN protection and functional improvement in ALS.
Wed Jul 01 00:00:00 EDT 2020
Human adipose tissue- and umbilical cord-derived stem cells: which is a better alternative to treat spinal cord injury?
Neural regeneration research
Liu AM,Chen BL,Yu LT,Liu T,Shi LL,Yu PP,Qu YB,So KF,Zhou LB
13-0300 was used in Immunocytochemistry-Immunofluorescence to suggest that human umbilical cord- and human adipose tissue-derived mesenchymal stem cell transplants both induce similar levels of anti-inflammation and improved axonal growth after spinal cord injury.
Tue Dec 01 00:00:00 EST 2020
Ferrochelatase regulates retinal neovascularization.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pran Babu SPS,White D,Corson TW
13-0300 was used in Immunohistochemistry (Frozen) to investigate the inhibition of Ferrochelatase using genetic and chemical approaches in the oxygen-induced retinopathy (OIR) mouse model.
Tue Sep 01 00:00:00 EDT 2020
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes.
Molecular neurobiology
Kagawa Y,Umaru BA,Shima H,Ito R,Zama R,Islam A,Kanno SI,Yasui A,Sato S,Jozaki K,Shil SK,Miyazaki H,Kobayashi S,Yamamoto Y,Kogo H,Shimamoto-Mitsuyama C,Sugawara A,Sugino N,Kanamori M,Tominaga T,Yoshikawa T,Fukunaga K,Igarashi K,Owada Y
13-0300 was used in Immunocytochemistry-immunoflourescence to explore the detailed mechanisms underlying FABP7 regulation of caveolin-1 expression using primary cultured FABP7-KO astrocytes as a model of loss of function and NIH-3T3 cells as a model of gain of function.
Tue Dec 01 00:00:00 EST 2020
Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.
Laboratory investigation; a journal of technical methods and pathology
Ouyang X,Ahmad I,Johnson MS,Redmann M,Craver J,Wani WY,Benavides GA,Chacko B,Li P,Young M,Jegga AG,Darley-Usmar V,Zhang J
13-0300 was used in Immunohistochemistry to show that knockout of nuclear receptor binding factor-2 in mice leads to learning and memory deficits.
Tue Sep 01 00:00:00 EDT 2020
Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesis.
Journal of cell science
Lim SH,Shin S,Kim MH,Kim EC,Lee DY,Moon J,Park HY,Ryu YK,Kang YM,Kang YJ,Kim TH,Lee NY,Kim NS,Yu DY,Shim I,Gondo Y,Satake M,Kim E,Kim KS,Min SS,Lee JR
13-0300 was used in Immunohistochemistry to show that the physiological roles of PTPRT in hippocampal neurogenesis, as well as synaptic functions, are involved in the pathogenesis of depressive disorder.
Wed Oct 21 00:00:00 EDT 2020
Generating Cell Type-Specific Protein Signatures from Non-symptomatic and Diseased Tissues.
Annals of biomedical engineering
Sadick JS,Crawford LA,Cramer HC,Franck C,Liddelow SA,Darling EM
13-0300 was used in Immunocytochemistry to demonstrate a technique to generate proteomic signatures of specific cell types within heterogeneous populations.
Sat Aug 01 00:00:00 EDT 2020
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
Experimental eye research
Losiewicz MK,Elghazi L,Fingar DC,Rajala RVS,Lentz SI,Fort PE,Abcouwer SF,Gardner TW
13-0300 was used in Immunohistochemistry to define the physiology of the inner retina, which is key for understanding the pathophysiology of optic neuropathies, glaucoma and diabetic retinopathy.
Sat Aug 01 00:00:00 EDT 2020
mTORC1 and mTORC2 expression in inner retinal neurons and glial cells.
Experimental eye research
Losiewicz MK,Elghazi L,Fingar DC,Rajala RVS,Lentz SI,Fort PE,Abcouwer SF,Gardner TW
13-0300 was used in Immunohistochemistry to define the physiology of the inner retina, which is key for understanding the pathophysiology of optic neuropathies, glaucoma and diabetic retinopathy.
Sat Aug 01 00:00:00 EDT 2020
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.
Molecular brain
Kajikawa K,Imaizumi K,Shinozaki M,Shibata S,Shindo T,Kitagawa T,Shibata R,Kamata Y,Kojima K,Nagoshi N,Matsumoto M,Nakamura M,Okano H
13-0300 was used in Immunohistochemistry, Immunocytochemistry to generate forebrain- and spinal cord-type NPCs from human iPSCs and graft them onto the injured spinal cord in mice.
Thu Sep 03 00:00:00 EDT 2020
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.
Molecular brain
Kajikawa K,Imaizumi K,Shinozaki M,Shibata S,Shindo T,Kitagawa T,Shibata R,Kamata Y,Kojima K,Nagoshi N,Matsumoto M,Nakamura M,Okano H
13-0300 was used in Immunohistochemistry, Immunocytochemistry to generate forebrain- and spinal cord-type NPCs from human iPSCs and graft them onto the injured spinal cord in mice.
Thu Sep 03 00:00:00 EDT 2020
Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.
Nature communications
O¿Shea TM,Wollenberg AL,Kim JH,Ao Y,Deming TJ,Sofroniew MV
13-0300 was used in Immunohistochemistry to probed the molecular factors that determine CNS foreign body responses in mice using a platform of injectable hydrogels readily modified to present interfaces with different physiochemical properties to host cells.
Fri Dec 04 00:00:00 EST 2020
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury.
International journal of molecular sciences
Espinosa-Garcia C,Atif F,Yousuf S,Sayeed I,Neigh GN,Stein DG
13-0300 was used in Immunohistochemistry to investigate the effect of progesterone on stress-induced microglial priming during ischaemia within in vitro and in vivo methods using rats.
Tue May 26 00:00:00 EDT 2020
Neuron labeling with rhodamine-conjugated Gd-based MRI contrast agents delivered to the brain via focused ultrasound.
Theranostics
Morse SV,Boltersdorf T,Harriss BI,Chan TG,Baxan N,Jung HS,Pouliopoulos AN,Choi JJ,Long NJ
13-0300 was used in Immunohistochemistry to investigate whether combining fluorescent rhodamine with a gadolinium complex would form a dual-modal contrast agent that could label neurons in vivo when delivered to the mouse brain with focused ultrasound and microbubbles.
Fri May 14 00:00:00 EDT 2021
Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress.
BMC complementary medicine and therapies
Kim HR,Lee YJ,Kim TW,Lim RN,Hwang DY,Moffat JJ,Kim S,Seo JW,Ka M
13-0300 was used in Immunohistochemistry to study the antidepressant effect of asparagus cochinchinensis extract in a rat model for menopausal depression.
Tue Oct 27 00:00:00 EDT 2020
Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.
Journal of neuroinflammation
Sigfridsson E,Marangoni M,Hardingham GE,Horsburgh K,Fowler JH
13-0300 was used in Immunohistochemistry to test hypothesis that white matter pathology, microgliosis, blood-brain barrier breakdown and behavioural deficits induced by chronic hypoperfusion would be exacerbated in mice deficient in the transcription factor Nrf2.
Tue Dec 01 00:00:00 EST 2020
Omega-3 Fatty Acid-Type Docosahexaenoic Acid Protects against Aβ-Mediated Mitochondrial Deficits and Pathomechanisms in Alzheimer's Disease-Related Animal Model.
International journal of molecular sciences
Park YH,Shin SJ,Kim HS,Hong SB,Kim S,Nam Y,Kim JJ,Lim K,Kim JS,Kim JI,Jeon SG,Moon M
13-0300 was used in Immunohistochemistry to investigate whether omega-3 inhibits Alzheimer's disease pathology related to mitochondria deficits.
Fri May 29 00:00:00 EDT 2020
LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Cell reports
Jeong D,Lozano Casasbuenas D,Gengatharan A,Edwards K,Saghatelyan A,Kaplan DR,Miller FD,Yuzwa SA
13-0300 was used in Immunocytochemistry to study the transition of neural stem cells from rapid to slow proliferative states in the developing neocortex.
Tue Oct 13 00:00:00 EDT 2020
LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Cell reports
Jeong D,Lozano Casasbuenas D,Gengatharan A,Edwards K,Saghatelyan A,Kaplan DR,Miller FD,Yuzwa SA
13-0300 was used in Immunocytochemistry to study the transition of neural stem cells from rapid to slow proliferative states in the developing neocortex.
Tue Oct 13 00:00:00 EDT 2020
Characterization of gastrointestinal pathologies in the dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI.
Neurogastroenterology and motility
Lynch-Godrei A,De Repentigny Y,Yaworski RA,Gagnon S,Butcher J,Manoogian J,Stintzi A,Kothary R
13-0300 was used in Immunohistochemistry to show that parasympathetic GI input showed signs of neurodegeneration, while sympathetic did not.Dstdt-27J GI defects are not linked to ENS neurodegeneration, but are likely a result of an imbalance in autonomic control over the gut.
Wed Apr 01 00:00:00 EDT 2020
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice.
Journal of neuroinflammation
Early AN,Gorman AA,Van Eldik LJ,Bachstetter AD,Morganti JM
13-0300 was used in Immunocytochemistry-immunoflourescence to highlight that TBI did not evoke a clear alignment with the previously defined "A1/A2" dichotomy of reactive astrogliosis.
Tue Apr 14 00:00:00 EDT 2020
The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.
Journal of neuroinflammation
Smith BC,Sinyuk M,Jenkins JE,Psenicka MW,Williams JL
13-0300 was used in Immunohistochemistry to reveal a protective role for IFNγ in chronic neuroinflammation and identify a novel function of the iP in astrocytes during CNS autoimmunity.
Fri Jun 12 00:00:00 EDT 2020
Neuroprotective and Anti-Inflammatory Effects of Low-Moderate Dose Ionizing Radiation in Models of Alzheimer's Disease.
International journal of molecular sciences
Kim S,Nam Y,Kim C,Lee H,Hong S,Kim HS,Shin SJ,Park YH,Mai HN,Oh SM,Kim KS,Yoo DH,Chung WK,Chung H,Moon M
13-0300 was used in Immunocytochemistry to examine the effect of low-dose ionizing radiation on Aβ accumulation and Aβ-mediated pathology.
Sat May 23 00:00:00 EDT 2020
NLRP3 inflammasome activation drives tau pathology.
Nature
Ising C,Venegas C,Zhang S,Scheiblich H,Schmidt SV,Vieira-Saecker A,Schwartz S,Albasset S,McManus RM,Tejera D,Griep A,Santarelli F,Brosseron F,Opitz S,Stunden J,Merten M,Kayed R,Golenbock DT,Blum D,Latz E,Buée L,Heneka MT
13-0300 was used in Immunohistochemistry to investigate the effect of the NLRP3 inflammasome on tau pathology.
Fri Nov 01 00:00:00 EDT 2019
Neuronal vulnerability and multilineage diversity in multiple sclerosis.
Nature
Schirmer L,Velmeshev D,Holmqvist S,Kaufmann M,Werneburg S,Jung D,Vistnes S,Stockley JH,Young A,Steindel M,Tung B,Goyal N,Bhaduri A,Mayer S,Engler JB,Bayraktar OA,Franklin RJM,Haeussler M,Reynolds R,Schafer DP,Friese MA,Shiow LR,Kriegstein AR,Rowitch DH
13-0300 was used in Immunohistochemistry to indicate multiple sclerosis lesion progression can be contributed through lineage- and region-specific transcriptomic changes associated with selective cortical neuron damage and glial activation.
Sun Sep 01 00:00:00 EDT 2019
Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.
Cell
Kim GB,Rincon Fernandez Pacheco D,Saxon D,Yang A,Sabet S,Dutra-Clarke M,Levy R,Watkins A,Park H,Abbasi Akhtar A,Linesch PW,Kobritz N,Chandra SS,Grausam K,Ayala-Sarmiento A,Molina J,Sedivakova K,Hoang K,Tsyporin J,Gareau DS,Filbin MG,Bannykh S,Santiskulvong C,Wang Y,Tang J,Suva ML,Chen B,Danielpour M,Breunig JJ
13-0300 was used in Immunohistochemistry to establish mosaic analysis by dual recombinase-mediated cassette exchange (MADR), which permits stable labeling of mutant cells expressing transgenic elements from precisely defined chromosomal loci.
Thu Sep 19 00:00:00 EDT 2019
T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.
Nature neuroscience
Garber C,Soung A,Vollmer LL,Kanmogne M,Last A,Brown J,Klein RS
13-0300 was used in Immunohistochemistry to determine whether hippocampal T cells that persist after recovery from infection with West Nile virus or Zika virus impact hippocampal-dependent learning and memory.
Thu Aug 01 00:00:00 EDT 2019
Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.
Journal of autoimmunity
Mattapallil MJ,Kielczewski JL,Zárate-Bladés CR,St Leger AJ,Raychaudhuri K,Silver PB,Jittayasothorn Y,Chan CC,Caspi RR
13-0300 was used in Immunohistochemistry to suggest that IL-22 can function locally within the retina to reduce inflammatory damage and provide neuroprotection by affecting multiple molecular and cellular pathways.
Thu Aug 01 00:00:00 EDT 2019
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model.
EMBO molecular medicine
Reichenbach N,Delekate A,Plescher M,Schmitt F,Krauss S,Blank N,Halle A,Petzold GC
13-0300 was used in Immunohistochemistry to identify Stat3-mediated astrogliosis as an important therapeutic target in Alzheimer's disease.
Fri Feb 01 00:00:00 EST 2019
Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice.
British journal of anaesthesia
Campos-Pires R,Hirnet T,Valeo F,Ong BE,Radyushkin K,Aldhoun J,Saville J,Edge CJ,Franks NP,Thal SC,Dickinson R
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate the effect of xenon on very long term outcomes and survival in mice.
Mon Jul 01 00:00:00 EDT 2019
Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis.
British journal of pharmacology
McLeod VM,Lau CL,Chiam MDF,Rupasinghe TW,Roessner U,Djouma E,Boon WC,Turner BJ
13-0300 was used in Immunohistochemistry to study the effect of androgen receptor antagonism in the SOD1G93A mouse model.
Mon Jul 01 00:00:00 EDT 2019
Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.
Stem cells translational medicine
Kojima K,Miyoshi H,Nagoshi N,Kohyama J,Itakura G,Kawabata S,Ozaki M,Iida T,Sugai K,Ito S,Fukuzawa R,Yasutake K,Renault-Mihara F,Shibata S,Matsumoto M,Nakamura M,Okano H
13-0300 was used in Immunohistochemistry to examine a potentially promising role of suicide genes in opposing tumourigenesis during stem cell therapy.
Fri Mar 01 00:00:00 EST 2019
Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Yang CY,Yu TH,Wen WL,Ling P,Hsu KS
13-0300 was used in Immunohistochemistry to establish a critical link between elevated Rac1 activity, structural and synaptic plasticity alterations, and cognitive impairment caused by Cc2d1a deletion.
Wed Jun 19 00:00:00 EDT 2019
Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lee BJ,Jun HO,Kim JH,Kim JH
13-0300 was used in Immunohistochemistry to investigate the role of cystine/glutamate antiporter in the regulation of astrocytic erythropoietin expression by using both in vitro and in vivo models in order to identify regulatory mechanism of erythropoietin expression in retinal ischemia.
Wed May 01 00:00:00 EDT 2019
Astrocyte-specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity.
Journal of neurochemistry
Michalovicz LT,Kelly KA,Vashishtha S,Ben-Hamo R,Efroni S,Miller JV,Locker AR,Sullivan K,Broderick G,Miller DB,O'Callaghan JP
13-0300 was used in Immunohistochemistry-immunofluorescence to demonstrate that bacTRAP can be used to identify new biomarkers of astrogliosis and aid in the characterization of astrocyte phenotypes induced by toxicant exposures.
Thu Aug 01 00:00:00 EDT 2019
Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization.
eLife
Ma W,Silverman SM,Zhao L,Villasmil R,Campos MM,Amaral J,Wong WT
13-0300 was used in Immunohistochemistry to study how TGFΒ signalling to microglia influences pathological retinal neuroinflammation.
Tue Jan 22 00:00:00 EST 2019
Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis.
Journal of neurochemistry
Burkovetskaya M,Bosch ME,Karpuk N,Fallet R,Kielian T
13-0300 was used in Immunohistochemistry-immunofluorescence to suggest that caspase 1 represents a potential therapeutic target to mitigate some attributes of CLN3 disease.
Fri Mar 01 00:00:00 EST 2019
Pannexin 1 Regulates Network Ensembles and Dendritic Spine Development in Cortical Neurons.
eNeuro
Sanchez-Arias JC,Liu M,Choi CSW,Ebert SN,Brown CE,Swayne LA
13-0300 was used in Western Blotting to study the underlying molecular mechanisms that regulate dendritic spine development in cortical neurons.
Mon Mar 30 00:00:00 EDT 2020
Visualization of spatiotemporal dynamics of human glioma stem cell invasion.
Molecular brain
Tamura R,Miyoshi H,Sampetrean O,Shinozaki M,Morimoto Y,Iwasawa C,Fukaya R,Mine Y,Masuda H,Maruyama T,Narita M,Saya H,Yoshida K,Okano H,Toda M
13-0300 was used in Immunohistochemistry on paraffin embedded tissues to study the spatiotemporal dynamics of invasion of human glioma stem cells in an orthotopic xenograft mouse model.
Mon May 06 00:00:00 EDT 2019
Deactivation of ATP-Binding Cassette Transporters ABCB1 and ABCC1 Does Not Influence Post-ischemic Neurological Deficits, Secondary Neurodegeneration and Neurogenesis, but Induces Subtle Microglial Morphological Changes.
Frontiers in cellular neuroscience
Manrique-Castano D,Sardari M,Silva de Carvalho T,Doeppner TR,Popa-Wagner A,Kleinschnitz C,Chan A,Hermann DM
13-0300 was used in Immunohistochemistry-immunofluorescence to study the effect of ATP-binding cassette transporter deactivation, on neurological deficits and brain injury, in a stroke model.
Thu Oct 01 00:00:00 EDT 2020
Stroke target identification guided by astrocyte transcriptome analysis.
Glia
Rakers C,Schleif M,Blank N,Matušková H,Ulas T,Händler K,Torres SV,Schumacher T,Tai K,Schultze JL,Jackson WS,Petzold GC
13-0300 was used in Immunohistochemistry to identify the differential expression of 1,003 genes and 38 transcription factors, of which Stat3, Sp1, and Spi1 were the most prominent.
Mon Apr 01 00:00:00 EDT 2019
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.
Aging
Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S
13-0300 was used in Immunocytochemistry-immunoflourescence to reveal that aging-associated dysfunctional autophagy contributes to senescence transition also in neuronal cells.
Fri Aug 30 00:00:00 EDT 2019
Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury.
Nature communications
Bellver-Landete V,Bretheau F,Mailhot B,Vallières N,Lessard M,Janelle ME,Vernoux N,Tremblay MÈ,Fuehrmann T,Shoichet MS,Lacroix S
13-0300 was used in Immunohistochemistry-immunofluorescence to assess the response of microglia following spinal cord injury.
Thu Jan 31 00:00:00 EST 2019
Neuronal Conditional Knockout of Collapsin Response Mediator Protein 2 Ameliorates Disease Severity in a Mouse Model of Multiple Sclerosis.
ASN neuro
Moutal A,Kalinin S,Kowal K,Marangoni N,Dupree J,Lin SX,Lis K,Lisi L,Hensley K,Khanna R,Feinstein DL
13-0300 was used in Immunohistochemistry to show that modification of CRMP2 expression and phosphorylation can influence the course of EAE and suggest that treatment with CRMP2 modulators such as LKE act in part by reducing CRMP2 S522 phosphorylation.
Wed May 13 00:00:00 EDT 2020
Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer.
Frontiers in cellular neuroscience
Gao L,Zhang Z,Lu J,Pei G
13-0300 was used in Immunohistochemistry to suggest that mitochondria dynamically transfer between neural cells and reveal that AxD-associated mutations in GFAP gene disrupted the astrocytic transfer.
Thu Oct 01 00:00:00 EDT 2020
Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Nature neuroscience
Kelley KW,Nakao-Inoue H,Molofsky AV,Oldham MC
13-0300 was used in Immunohistochemistry to examine the core transcriptional identities of major central nervous system cell classes in humans.
Sat Sep 01 00:00:00 EDT 2018
Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.
Biomaterials
Wollenberg AL,O'Shea TM,Kim JH,Czechanski A,Reinholdt LG,Sofroniew MV,Deming TJ
13-0300 was used in Immunohistochemistry to demonstrate that Met-based DCH are suitable vehicles for further study of NSPC transplantation in CNS injury and disease models.
Sat Sep 01 00:00:00 EDT 2018
Blood-brain barrier shuttle peptides enhance AAV transduction in the brain after systemic administration.
Biomaterials
Zhang X,He T,Chai Z,Samulski RJ,Li C
13-0300 was used in Immunohistochemistry to study the efficacy of BBB shuttle peptides in transporting systemically administered AAV vectors pass the blood brain barrier to achieve brain penetration.
Sat Sep 01 00:00:00 EDT 2018
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Developmental cell
Zhao C,Dong C,Frah M,Deng Y,Marie C,Zhang F,Xu L,Ma Z,Dong X,Lin Y,Koenig S,Nait-Oumesmar B,Martin DM,Wu LN,Xin M,Zhou W,Parras C,Lu QR
13-0300 was used in Immunohistochemistry to demonstrate the dual function of CHD8 through inducing a cascade of chromatin reprogramming and recruiting H3K4 histone methyltransferases to establish oligodendrocyte identity.
Mon Jun 18 00:00:00 EDT 2018
Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Developmental cell
Zhao C,Dong C,Frah M,Deng Y,Marie C,Zhang F,Xu L,Ma Z,Dong X,Lin Y,Koenig S,Nait-Oumesmar B,Martin DM,Wu LN,Xin M,Zhou W,Parras C,Lu QR
13-0300 was used in Immunohistochemistry to demonstrate the dual function of CHD8 through inducing a cascade of chromatin reprogramming and recruiting H3K4 histone methyltransferases to establish oligodendrocyte identity.
Mon Jun 18 00:00:00 EDT 2018
Characterization of the ventricular-subventricular stem cell niche during human brain development.
Development (Cambridge, England)
Coletti AM,Singh D,Kumar S,Shafin TN,Briody PJ,Babbitt BF,Pan D,Norton ES,Brown EC,Kahle KT,Del Bigio MR,Conover JC
13-0300 was used in Immunohistochemistry-immunofluorescence to reveal normal human V-SVZ development, highlighting the consequence of disease pathologies such as congenital hydrocephalus.
Fri Oct 26 00:00:00 EDT 2018
Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Alawieh A,Langley EF,Weber S,Adkins D,Tomlinson S
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate how complement is involved in neurodegeneration and chronic neuroinflammation following traumatic brain injury in a clinically relevant setting of complement inhibition.
Wed Mar 07 00:00:00 EST 2018
Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chalermpalanupap T,Schroeder JP,Rorabaugh JM,Liles LC,Lah JJ,Levey AI,Weinshenker D
13-0300 was used in Immunohistochemistry-immunofluorescence to investigate the impact of locus coeruleus degeneration in a mouse model of tauopathy.
Wed Jan 03 00:00:00 EST 2018
Injury type-dependent differentiation of NG2 glia into heterogeneous astrocytes.
Experimental neurology
Hackett AR,Yahn SL,Lyapichev K,Dajnoki A,Lee DH,Rodriguez M,Cammer N,Pak J,Mehta ST,Bodamer O,Lemmon VP,Lee JK
13-0300 was used in Immunohistochemistry to demonstrate that a heterogeneous population of astrocytes are derived from NG2 glia in an injury type-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia.
Journal of neurochemistry
Esposito E,Hayakawa K,Ahn BJ,Chan SJ,Xing C,Liang AC,Kim KW,Arai K,Lo EH
13-0300 was used in Immunohistochemistry to investigate whether postconditioning may modulate help-me signaling between injured neurons and reactive microglia.
Sun Jul 01 00:00:00 EDT 2018
Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice.
Journal of neurovirology
Zukor K,Wang H,Siddharthan V,Julander JG,Morrey JD
13-0300 was used in Immunohistochemistry-immunofluorescence to study the infection of adult astrocytes and neurons by a contemporary strain of Zika virus in interferon α/Β receptor knockout mice.
Fri Jun 01 00:00:00 EDT 2018
Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.
Journal of neuroimmunology
McLane VD,Kumar S,Leeming R,Rau S,Willis CL,Cao L
13-0300 was used in Immunohistochemistry to suggest that differentially regulated type 1 IFN responses may contribute to distinct regional outcomes in the hippocampus and striatum in LP-BM5/MAIDS.
Fri Jun 15 00:00:00 EDT 2018
Involvement of aquaporin-4 in laminin-enhanced process formation of mouse astrocytes in 2D culture: Roles of dystroglycan and α-syntrophin in aquaporin-4 expression.
Journal of neurochemistry
Sato J,Horibe S,Kawauchi S,Sasaki N,Hirata KI,Rikitake Y
13-0300 was used in Immunohistochemistry-immunofluorescence to indicate that the laminin-dystroglycan-α-syntrophin-AQP4 axis is important for process formation and branching of 2D cultured astrocytes.
Thu Nov 01 00:00:00 EDT 2018
Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer.
Nature communications
Baruteau J,Perocheau DP,Hanley J,Lorvellec M,Rocha-Ferreira E,Karda R,Ng J,Suff N,Diaz JA,Rahim AA,Hughes MP,Banushi B,Prunty H,Hristova M,Ridout DA,Virasami A,Heales S,Howe SJ,Buckley SMK,Mills PB,Gissen P,Waddington SN
13-0300 was used in Immunohistochemistry-immunofluorescence to study the role of neuronal oxidative/nitrosative stress independent of hyperammonaemia in the cerebral disease in argininosuccinic aciduria.
Wed Aug 29 00:00:00 EDT 2018
CREB controls cortical circuit plasticity and functional recovery after stroke.
Nature communications
Caracciolo L,Marosi M,Mazzitelli J,Latifi S,Sano Y,Galvan L,Kawaguchi R,Holley S,Levine MS,Coppola G,Portera-Cailliau C,Silva AJ,Carmichael ST
13-0300 was used in Immunohistochemistry to show that CREB is a central molecular node in the circuit responses after stroke that lead to recovery from motor deficits.
Fri Jun 08 00:00:00 EDT 2018
Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.
Stem cell reports
Storer MA,Gallagher D,Fatt MP,Simonetta JV,Kaplan DR,Miller FD
13-0300 was used in Immunocytochemistry to study the role of interleukin-6 signalling in adult neural stem cell self-renewal.
Tue May 08 00:00:00 EDT 2018
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
eLife
Schirmer L,Möbius W,Zhao C,Cruz-Herranz A,Ben Haim L,Cordano C,Shiow LR,Kelley KW,Sadowski B,Timmons G,Pröbstel AK,Wright JN,Sin JH,Devereux M,Morrison DE,Chang SM,Sabeur K,Green AJ,Nave KA,Franklin RJ,Rowitch DH
13-0300 was used in Immunohistochemistry to suggest a critical role of oligodendrocyte-Kir4.1 for long-term maintenance of axonal function and integrity during adulthood and after white matter injury.
Tue Sep 11 00:00:00 EDT 2018
Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice.
Viruses
Morrey JD,Wang H,Hurst BL,Zukor K,Siddharthan V,Van Wettere AJ,Sinex DG,Tarbet EB
13-0300 was used in Immunofluorescence in immunohistochemistry on frozen tissues to evaluate Enterovirus D68 infection in non-lethal paralysis mouse models.
Fri Jan 12 00:00:00 EST 2018
Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
Scientific reports
Muthusamy N,Brumm A,Zhang X,Carmichael ST,Ghashghaei HT
13-0300 was used in Immunohistochemistry to study whether Foxj1+ ependymal stem cells participate in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain.
Mon Jan 29 00:00:00 EST 2018
Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier.
Scientific reports
Mäe MA,Li T,Bertuzzi G,Raschperger E,Vanlandewijck M,He L,Nahar K,Dalheim A,Hofmann JJ,Laviña B,Keller A,Betsholtz C,Genové G
13-0300 was used in Immunohistochemistry to study whether prolonged systemic hyperglycaemia induces blood-brain barrier dysfunction and leakage.
Thu Nov 29 00:00:00 EST 2018
Neurotoxic reactive astrocytes are induced by activated microglia.
Nature
Liddelow SA,Guttenplan KA,Clarke LE,Bennett FC,Bohlen CJ,Schirmer L,Bennett ML,Münch AE,Chung WS,Peterson TC,Wilton DK,Frouin A,Napier BA,Panicker N,Kumar M,Buckwalter MS,Rowitch DH,Dawson VL,Dawson TM,Stevens B,Barres BA
13-0300 was used in immunohistochemistry - frozen section to identify an astrocyte subtype induced by activated microglia
Thu Jan 26 00:00:00 EST 2017
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
The Journal of clinical investigation
Horng S,Therattil A,Moyon S,Gordon A,Kim K,Argaw AT,Hara Y,Mariani JN,Sawai S,Flodby P,Crandall ED,Borok Z,Sofroniew MV,Chapouly C,John GR
13-0300 was used in Immunofluorescence to identify a inducible barrier to CNS entry at the glia limitans, which may be therapeutically targetable in inflammatory CNS disease.
Tue Aug 01 00:00:00 EDT 2017
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage.
Neuron
Petersen MA,Ryu JK,Chang KJ,Etxeberria A,Bardehle S,Mendiola AS,Kamau-Devers W,Fancy SPJ,Thor A,Bushong EA,Baeza-Raja B,Syme CA,Wu MD,Rios Coronado PE,Meyer-Franke A,Yahn S,Pous L,Lee JK,Schachtrup C,Lassmann H,Huang EJ,Han MH,Absinta M,Reich DS,Ellisman MH,Rowitch DH,Chan JR,Akassoglou K
13-0300 was used in Western Blotting to determine the role of blood derived molecules as extrinsic inhibitors of remyelination after vascular damage.
Wed Dec 06 00:00:00 EST 2017
Regulation of RhoA by STAT3 coordinates glial scar formation.
The Journal of cell biology
Renault-Mihara F,Mukaino M,Shinozaki M,Kumamaru H,Kawase S,Baudoux M,Ishibashi T,Kawabata S,Nishiyama Y,Sugai K,Yasutake K,Okada S,Nakamura M,Okano H
13-0300 was used in Western Blotting to study the novel intracellular signalling mechanisms underlying the contribution of reactive astrocyte dynamics to glial scar formation.
Mon Aug 07 00:00:00 EDT 2017
P2Y12 receptor is expressed on human microglia under physiological conditions throughout development and is sensitive to neuroinflammatory diseases.
Glia
Mildner A,Huang H,Radke J,Stenzel W,Priller J
130300 was used in immunohistochemistry - paraffin section to study P2Y12 expression in human brain tissue
Wed Feb 01 00:00:00 EST 2017
Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.
Glia
Menzel L,Kleber L,Friedrich C,Hummel R,Dangel L,Winter J,Schmitz K,Tegeder I,Schäfer MK
130300 was used in immunohistochemistry - frozen section to examine inflammatory markers in progranulin-deficient mice
Wed Feb 01 00:00:00 EST 2017
Magnetic resonance microdynamic imaging reveals distinct tissue microenvironments.
NeuroImage
Benjamini D,Basser PJ
13-0300 was used in Immunohistochemistry to develop a novel magnetic resonance imaging framework allowing for the simultaneous non-invasive and model-free quantification of multiple subcellular, cellular, and interstitial tissue microenvironments within a voxel.
Fri Dec 01 00:00:00 EST 2017
Astrocyte heme oxygenase-1 reduces mortality and improves outcome after collagenase-induced intracerebral hemorrhage.
Neurobiology of disease
Chen-Roetling J,Kamalapathy P,Cao Y,Song W,Schipper HM,Regan RF
13-0300 was used in Immunohistochemistry on frozen tissues to suggest that astrocyte haem oxygenase-1 overexpression provides robust neuroprotection after acute intracerebral haemorrhage.
Thu Jun 01 00:00:00 EDT 2017
Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage.
Neurobiology of disease
Chang CF,Wan J,Li Q,Renfroe SC,Heller NM,Wang J
13-0300 was used in Immunohistochemistry-immunofluorescence to characterise microglia/macrophage dynamics after intracerebral haemorrhage in mice and evaluate the relevance of microglia/macrophage polarity to haematoma resolution.
Sat Jul 01 00:00:00 EDT 2017
Macrophage Transcriptional Profile Identifies Lipid Catabolic Pathways That Can Be Therapeutically Targeted after Spinal Cord Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Lyapichev K,Lee DH,Motti D,Ferraro NM,Zhang Y,Yahn S,Soderblom C,Zha J,Bethea JR,Spiller KL,Lemmon VP,Lee JK
13-0300 was used in Immunohistochemistry to report the first macrophage-specific transcriptional profile after spinal cord injury (SCI) and highlight the lipid catabolic pathway as an important macrophage function and therapeutically target.
Wed Mar 01 00:00:00 EST 2017
Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang X,Zhao L,Zhang Y,Ma W,Gonzalez SR,Fan J,Kretschmer F,Badea TC,Qian HH,Wong WT
13-0300 was used in Immunohistochemistry to find that in two separate mouse models of photoreceptor degeneration, tamoxifen provides potent neuroprotective effects.
Wed Mar 22 00:00:00 EDT 2017
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.
Journal of cell science
Behm M,Wahlstedt H,Widmark A,Eriksson M,Öhman M
130300 was used in western blot to elucidate how nuclear editing of substrates contributes to neuronal function and brain development
Wed Feb 15 00:00:00 EST 2017
Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice.
Investigative ophthalmology & visual science
Yungher BJ,Ribeiro M,Park KK
130300 was used in western blot to study retinal ganglion cell axon regeneration following therapeutic delivery that is postponed until 2 months after optic nerve crush injury
Wed Mar 01 00:00:00 EST 2017
Phrenic nerve deficits and neurological immunopathology associated with acute West Nile virus infection in mice and hamsters.
Journal of neurovirology
Zukor K,Wang H,Hurst BL,Siddharthan V,Van Wettere A,Pilowsky PM,Morrey JD
130300 was used in immunohistochemistry to test if the respiratory deficits in West Nile virus-infected rodents are neurological
Sat Apr 01 00:00:00 EDT 2017
Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats.
The Journal of comparative neurology
Park KK,Luo X,Mooney SJ,Yungher BJ,Belin S,Wang C,Holmes MM,He Z
13-0300 was used in immunohistochemistry to elucidate optic nerve injury in naked mole-rats and axon regeneration and retinal ganglion cell survival
Wed Feb 01 00:00:00 EST 2017
Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes.
Journal of neuroscience methods
Li X,Cao VY,Zhang W,Mastwal SS,Liu Q,Otte S,Wang KH
13-0300 was used in Immunohistochemistry-immunofluorescence to develop a cranial surgery technique allowing for high-yield calcium imaging of cortical neurons with head-mounted microscopes in freely behaving animals.
Wed Nov 01 00:00:00 EDT 2017
FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand.
Bio-protocol
Tome-Garcia J,Doetsch F,Tsankova NM
13-0300 was used in Flow cytometry/Cell sorting to describe the purification methodology of EGF-bound human neural and glioma cells with stem cell properties from postmortem and surgical tissues.
Wed Dec 20 00:00:00 EST 2017
Inhibition of neuronal ferroptosis protects hemorrhagic brain.
JCI insight
Li Q,Han X,Lan X,Gao Y,Wan J,Durham F,Cheng T,Yang J,Wang Z,Jiang C,Ying M,Koehler RC,Stockwell BR,Wang J
13-0300 was used in Immunohistochemistry to evaluate the contribution of neuronal ferroptosis to neuronal cell death following intracerebral haemorrhage, and identify biomarkers and treatments.
Thu Apr 06 00:00:00 EDT 2017
Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis.
Neuropathology and applied neurobiology
Duncombe J,Lennen RJ,Jansen MA,Marshall I,Wardlaw JM,Horsburgh K
13-0300 was used in Immunohistochemistry to conclude that strategies aimed to restore the loss of astrocytic end feet contact and reduce gliosis may improve neurovascular coupling.
Sun Oct 01 00:00:00 EDT 2017
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Nature communications
Morizawa YM,Hirayama Y,Ohno N,Shibata S,Shigetomi E,Sui Y,Nabekura J,Sato K,Okajima F,Takebayashi H,Okano H,Koizumi S
13-0300 was used in Immunohistochemistry to show that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
Thu Jun 22 00:00:00 EDT 2017
Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.
Scientific reports
Kodo K,Shibata S,Miyagawa-Tomita S,Ong SG,Takahashi H,Kume T,Okano H,Matsuoka R,Yamagishi H
13-0300 was used in Immunocytochemistry to show that Sema3c is a candidate that mediates interaction between cardiac neural crest cells and the second heart field during development of the outflow tract.
Fri Jul 28 00:00:00 EDT 2017
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination.
PloS one
Chami M,Halmer R,Schnoeder L,Anne Becker K,Meier C,Fassbender K,Gulbins E,Walter S
13-0300 was used in Immunohistochemistry to study glial reaction and oligodendrocyte distribution in acid sphingomyelinase deficient mice and wild-type C57BL/6J littermates at various time intervals after demyelination and remyelination.
Mon Sep 18 00:00:00 EDT 2017
3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.
Nature medicine
Wang Y,Zhao Z,Rege SV,Wang M,Si G,Zhou Y,Wang S,Griffin JH,Goldman SA,Zlokovic BV
13-0300 was used in Immunohistochemistry to show that 3K3A-Activated protein C-potentiated neuronal recruitment from engrafted neural stem and progenitor cells might offer a new approach to the treatment of stroke and related neurological disorders.
Thu Sep 01 00:00:00 EDT 2016
A complement-microglial axis drives synapse loss during virus-induced memory impairment.
Nature
Vasek MJ,Garber C,Dorsey D,Durrant DM,Bollman B,Soung A,Yu J,Perez-Torres C,Frouin A,Wilton DK,Funk K,DeMasters BK,Jiang X,Bowen JR,Mennerick S,Robinson JK,Garbow JR,Tyler KL,Suthar MS,Schmidt RE,Stevens B,Klein RS
13-0300 was used in immunohistochemistry - frozen section to characterize the drive of synapse loss during virus-induced memory impairment by a complement-microglial axis
Thu Jun 23 00:00:00 EDT 2016
STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury.
Neurobiology of disease
Hackett AR,Lee DH,Dawood A,Rodriguez M,Funk L,Tsoulfas P,Lee JK
13-0300 was used in Immunohistochemistry to identify GFAP astrocytes in NG2 cell proliferation, to understand the mechanism of STAT3 and SOCS3 regulation in response to CNS injury.
Sun May 01 00:00:00 EDT 2016
Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ji B,Kaneko H,Minamimoto T,Inoue H,Takeuchi H,Kumata K,Zhang MR,Aoki I,Seki C,Ono M,Tokunaga M,Tsukamoto S,Tanabe K,Shin RM,Minamihisamatsu T,Kito S,Richmond BJ,Suhara T,Higuchi M
130300 was used in immunohistochemistry to use clozapine-N-oxide a functional reporter probe for positron emission tomography to study designer receptor exclusively activated by designer drugs in living brains
Wed Nov 09 00:00:00 EST 2016
Epigenetic regulation of neural N-glycomics.
Proteomics
Kizuka Y,Nakano M,Miura Y,Taniguchi N
13-0300 was used in immunocytochemistry to study neural N-glycomics and their epigenetic regulation
Tue Nov 01 00:00:00 EDT 2016
Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.
Gene therapy
Jara JH,Stanford MJ,Zhu Y,Tu M,Hauswirth WW,Bohn MC,DeVries SH,Özdinler PH
13-0300 was used in Immunocytochemistry to demonstrate improved transduction efficiency of corticospinal motor neurons by AAV2-2 CBA in a preclinical model.
Tue Mar 01 00:00:00 EST 2016
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.
The Biochemical journal
Kizuka Y,Nakano M,Kitazume S,Saito T,Saido TC,Taniguchi N
13-0300 was used in immunocytochemistry to test if bisecting GlcNAc would stabilize BACE1 protein upon oxidative stress.
Fri Jan 01 00:00:00 EST 2016
The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice.
Neuroscience
Smeester BA,O'Brien EE,Michlitsch KS,Lee JH,Beitz AJ
13-0300 was used in immunohistochemistry - frozen section to study the relationship between aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice with bone-tumor-induced spinal cord astrocyte a
Thu Jun 02 00:00:00 EDT 2016
CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells.
Neuroscience
Zhang L,Hua Q,Tang K,Shi C,Xie X,Zhang R
130300 was used in immunocytochemistry to find that CXCR4 is involved in the differentiation of human embryonic stem cells to neural stem cells
Sat Nov 19 00:00:00 EST 2016
Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.
Biology of the cell
Walker WP,Oehler A,Edinger AL,Wagner KU,Gunn TM
13-0300 was used in immunohistochemistry - paraffin section to test if central nervous system vacuolation in Mgrn1 null mice results in the accumulation of multi-cisternal endosome-like vacuolar protein sorting compartments
Tue Nov 01 00:00:00 EDT 2016
Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.
PloS one
Song D,Wilson B,Zhao L,Bhuyan R,Bandyopadhyay M,Lyubarsky A,Yu C,Li Y,Kanu L,Miwa T,Song WC,Finnemann SC,Rohrer B,Dunaief JL
130300 was used in immunohistochemistry - frozen section to use knockout mice to determine the retinal function of CD59a
Tue Jun 27 00:00:00 EDT 2017
Isolation and Culture of Adult Neural Stem Cells from the Mouse Subcallosal Zone.
Journal of visualized experiments : JoVE
Kim JY,Lee JH,Sun W
130300 was used in immunocytochemistry to discuss the process to generate subcallosal zone-adult neural stem cells from an adult mouse brain
Thu Dec 15 00:00:00 EST 2016
Cuprizone demyelination induces a unique inflammatory response in the subventricular zone.
Journal of neuroinflammation
Hillis JM,Davies J,Mundim MV,Al-Dalahmah O,Szele FG
13-0300 was used in immunohistochemistry - frozen section characterize microglia in the subventricular zone
Mon Aug 22 00:00:00 EDT 2016
TREM2 regulates microglial cell activation in response to demyelination in vivo.
Acta neuropathologica
Cantoni C,Bollman B,Licastro D,Xie M,Mikesell R,Schmidt R,Yuede CM,Galimberti D,Olivecrona G,Klein RS,Cross AH,Otero K,Piccio L
13-0300 was used in immunohistochemistry to investigate the contribution of TREM2 to microglia function in vivo
Sun Mar 01 00:00:00 EST 2015
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.
EMBO molecular medicine
Kizuka Y,Kitazume S,Fujinawa R,Saito T,Iwata N,Saido TC,Nakano M,Yamaguchi Y,Hashimoto Y,Staufenbiel M,Hatsuta H,Murayama S,Manya H,Endo T,Taniguchi N
13-0300 was used in immunohistochemistry - frozen section to study the effect of bisecting N-acetylglucosamine on beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) activity.
Sun Feb 01 00:00:00 EST 2015
Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination.
Glia
Puntambekar SS,Hinton DR,Yin X,Savarin C,Bergmann CC,Trapp BD,Stohlman SA
13-0300 was used in immunohistochemistry (paraffin) to study the contribution of IL-10 to virus-induced demyelination.
Sun Nov 01 00:00:00 EDT 2015
Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury.
Neurobiology of disease
Zhu Y,Soderblom C,Krishnan V,Ashbaugh J,Bethea JR,Lee JK
13-0300 was used in immunohistochemistry to investigate the effect of hematogenous macrophage depletion on fibrotic scar and axonal growth after spinal cord injury.
Sun Feb 01 00:00:00 EST 2015
Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Crouch EE,Liu C,Silva-Vargas V,Doetsch F
13-0300 was used in immunocytochemistry to develop a strategy to define the functional and molecular contribution of vascular cells to stem cell niches in the brain
Wed Mar 18 00:00:00 EDT 2015
Pten Mutations Alter Brain Growth Trajectory and Allocation of Cell Types through Elevated β-Catenin Signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen Y,Huang WC,Séjourné J,Clipperton-Allen AE,Page DT
13-0300 was used in immunohistochemistry to show that Pten and β-catenin signaling regulates normal brain growth trajectory by controlling cell number.
Wed Jul 15 00:00:00 EDT 2015
Fibronectin Matrix Assembly after Spinal Cord Injury.
Journal of neurotrauma
Zhu Y,Soderblom C,Trojanowsky M,Lee DH,Lee JK
13-0300 was used in immunohistochemistry to investigate the assembly of fibronectin matrix after spinal cord injury.
Sat Aug 01 00:00:00 EDT 2015
Interferon-gamma promotes infection of astrocytes by Trypanosoma cruzi.
PloS one
Silva RR,Mariante RM,Silva AA,dos Santos AL,Roffê E,Santiago H,Gazzinelli RT,Lannes-Vieira J
13-0300 was used in Immunocytochemistry-immunoflourescence to investigate the effect of IFNγ in the central nervous system and on astrocytes during Chagas disease.
Thu Dec 31 00:00:00 EST 2015
The BRAF kinase domain promotes the development of gliomas in vivo.
Genes & cancer
Shin CH,Grossmann AH,Holmen SL,Robinson JP
13-0300 was used in immunohistochemistry (paraffin) to assess if BRAF-KD is sufficient to induce gliomas or if Ink4a/Arf loss is also needed.
Thu Jan 01 00:00:00 EST 2015
Dorsal raphe neuroinflammation promotes dramatic behavioral stress dysregulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Howerton AR,Roland AV,Bale TL
13-0300 was used in immunohistochemistry to study the role of neuroinflammation in behavioral stress dysregulation and its mechanism.
Wed May 21 00:00:00 EDT 2014
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells.
Stem cells and development
Kawase S,Kuwako K,Imai T,Renault-Mihara F,Yaguchi K,Itohara S,Okano H
13-0300 was used in immunohistochemistry to elucidate the regulatory mechanisms by which Msi1 is selectively expressed in neural stem/progenitor cells
Mon Sep 15 00:00:00 EDT 2014
Neuregulin-1/glial growth factor stimulates Schwann cell migration by inducing α5 β1 integrin-ErbB2-focal adhesion kinase complex formation.
Genes to cells : devoted to molecular & cellular mechanisms
Wakatsuki S,Araki T,Sehara-Fujisawa A
13-0300 was used in immunohistochemistry and western blot to study the role of neuregulin-1/glial growth factor in Schwann cell migration and its mechanism
Wed Jan 01 00:00:00 EST 2014
PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system.
Nature communications
Puttagunta R,Tedeschi A,Sória MG,Hervera A,Lindner R,Rathore KI,Gaub P,Joshi Y,Nguyen T,Schmandke A,Laskowski CJ,Boutillier AL,Bradke F,Di Giovanni S
13-0300 was used in Immunohistochemistry-immunofluorescence to study a specific epigenetic mechanism that regulates axonal regeneration of central nervous system axons.
Tue Apr 01 00:00:00 EDT 2014
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model.
Nature communications
Delekate A,Füchtemeier M,Schumacher T,Ulbrich C,Foddis M,Petzold GC
13-0300 was used in Immunohistochemistry to suggest that astroglial network dysfunction is mediated by purinergic signalling in reactive astrocytes.
Wed Nov 19 00:00:00 EST 2014
Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions.
Annals of neurology
Schirmer L,Srivastava R,Kalluri SR,Böttinger S,Herwerth M,Carassiti D,Srivastava B,Gempt J,Schlegel J,Kuhlmann T,Korn T,Reynolds R,Hemmer B
13-0300 was used in Immunohistochemistry to analyze the expression pattern of KIR4.1 in normal brain tissue and MS lesions of the subcortical white matter by immunohistochemistry.
Sun Jun 01 00:00:00 EDT 2014
Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K/Akt signaling.
PloS one
Wu CH,Hung TH,Chen CC,Ke CH,Lee CY,Wang PY,Chen SF
13-0300 was used in immunohistochemistry to study the effects and underlying mechanisms of TrkB activation on traumatic brain injury
Wed Dec 30 00:00:00 EST 2015
ABCA1 influences neuroinflammation and neuronal death.
Neurobiology of disease
Karasinska JM,de Haan W,Franciosi S,Ruddle P,Fan J,Kruit JK,Stukas S,Lütjohann D,Gutmann DH,Wellington CL,Hayden MR
13-0300 was used in immunohistochemistry - frozen section to elucidate the cell-type specific role of ABCA in neuroinflammation in vivo.
Sat Jun 01 00:00:00 EDT 2013
Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.
Journal of virology
Phares TW,Stohlman SA,Hinton DR,Bergmann CC
13-0300 was used in immunohistochemistry (paraffin) to report that central nervous system-expressed CXCR3 ligand CXCL10 is the critical chemokine regulating antibody-secreting cells accumulation.
Fri Mar 01 00:00:00 EST 2013
Tissue-type plasminogen activator is an extracellular mediator of Purkinje cell damage and altered gait.
Experimental neurology
Cops EJ,Sashindranath M,Daglas M,Short KM,da Fonseca Pereira C,Pang TY,Lijnen RH,Smyth IM,Hannan AJ,Samson AL,Medcalf RL
13-0300 was used in western blot to study the involvement of tissue-type plasminogen activator in Purkinje cell damage
Fri Nov 01 00:00:00 EDT 2013
Ependymal ciliary dysfunction and reactive astrocytosis in a reorganized subventricular zone after stroke.
Cerebral cortex (New York, N.Y. : 1991)
Young CC,van der Harg JM,Lewis NJ,Brooks KJ,Buchan AM,Szele FG
13-0300 was used in Immunohistochemistry to demonstrate that in response to stroke there is significant SVZ reorganization with implications for both pathophysiology and therapeutic strategies.
Fri Mar 01 00:00:00 EST 2013
p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Floriddia EM,Rathore KI,Tedeschi A,Quadrato G,Wuttke A,Lueckmann JM,Kigerl KA,Popovich PG,Di Giovanni S
13-0300 was used in Immunohistochemistry to study the role of p53 as a key modifier of axonal and glial responses influencing functional recovery following spinal chord injury.
Wed Oct 03 00:00:00 EDT 2012
Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice.
Journal of neuroimmunology
Lutz SE,Raine CS,Brosnan CF
13-0300 was used in immunohistochemistry - paraffin section to test if loss of astrocytic gap junction proteins enhances primary demyelinating diseases.
Sun Apr 01 00:00:00 EDT 2012
Partial change in EphA4 knockout mouse phenotype: loss of diminished GFAP upregulation following spinal cord injury.
Neuroscience letters
Dixon KJ,Munro KM,Boyd AW,Bartlett PF,Turnley AM
13-0300 was used in immunohistochemistry - frozen section to re-examine astrocytic gliosis following injury using mice from our EphA4 null colony.
Thu Sep 06 00:00:00 EDT 2012
Biohybrid Carbon Nanotube/Agarose Fibers for Neural Tissue Engineering.
Advanced functional materials
Lewitus DY,Landers J,Branch J,Smith KL,Callegari G,Kohn J,Neimark AV
13-0300 was used in immunohistochemistry to report a novel approach for producing carbon nanotube fibers using polysaccharide agarose.
Fri Jul 22 00:00:00 EDT 2011
Ultrafast resorbing polymers for use as carriers for cortical neural probes.
Acta biomaterialia
Lewitus D,Smith KL,Shain W,Kohn J
13-0300 was used in immunohistochemistry to describe a novel tyrosine-derived terpolymer for use in flexible neural prosthetic devices.
Wed Jun 01 00:00:00 EDT 2011
CCAAT/enhancer binding protein-δ expression by dendritic cells regulates CNS autoimmune inflammatory disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tsai VW,Mohammad MG,Tolhurst O,Breit SN,Sawchenko PE,Brown DA
13-0300 was used in Immunohistochemistry to investigate the mechanisms involving C/EBPδ in mediating bystander neuronal injury and CNS autoimmune inflammatory disease.
Wed Nov 30 00:00:00 EST 2011
Factors supporting intrathecal humoral responses following viral encephalomyelitis.
Journal of virology
Phares TW,Marques CP,Stohlman SA,Hinton DR,Bergmann CC
13-0300 was used in immunohistochemistry - frozen section to study antibody secreting cell homing, differentiation, and survival in the spinal cord.
Tue Mar 01 00:00:00 EST 2011
Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage.
The American journal of pathology
Chang CF,Chen SF,Lee TS,Lee HF,Chen SF,Shyue SK
13-0300 was used in immunohistochemistry to determine the role of caveolin-1 in intracerebral hemorrhage.
Fri Apr 01 00:00:00 EDT 2011
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.
Biological psychiatry
Yang H,Zhuo JM,Chu J,Chinnici C,Praticò D
13-0300 was used in western blot to discuss the role of 12/15 lipoxygenase in Alzheimer's disease
Mon Nov 15 00:00:00 EST 2010
Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.
Proceedings of the National Academy of Sciences of the United States of America
Pozniak CD,Langseth AJ,Dijkgraaf GJ,Choe Y,Werb Z,Pleasure SJ
Tue Dec 14 00:00:00 EST 2010
In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis.
Glia
DellaValle B,Hempel C,Kurtzhals JA,Penkowa M
13-0300 was used in immunohistochemistry to study the localization and regulation of Ngb in different neuropathological models in vivo
Sun Aug 01 00:00:00 EDT 2010
Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice.
Pigment cell & melanoma research
VanBrocklin MW,Robinson JP,Lastwika KJ,Khoury JD,Holmen SL
13-0300 was used in immunohistochemistry to assess the role of RAS isoforms in melanoma initiation using conditional Ink4a/Arf knockout mice
Sun Aug 01 00:00:00 EDT 2010
Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
The Journal of comparative neurology
Hoff S,Zeller F,von Weyhern CW,Wegner M,Schemann M,Michel K,Rühl A
13-0300 was used in immunohistochemistry to quantitate glial cells in the human and guinea pig enteric nervous system.
Fri Aug 01 00:00:00 EDT 2008
Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody.
The Journal of comparative neurology
Hoff S,Zeller F,von Weyhern CW,Wegner M,Schemann M,Michel K,Rühl A
13-0300 was used in immunohistochemistry to quantitate glial cells in the human and guinea pig enteric nervous system.
Fri Aug 01 00:00:00 EDT 2008
Diverse microglial responses after intrahippocampal administration of lipopolysaccharide.
Glia
Herber DL,Maloney JL,Roth LM,Freeman MJ,Morgan D,Gordon MN
13-0300 was used in immunohistochemistry - free floating to study the time course of microgliosis after a single intrahippocampal injection of lipopolysaccharide
Wed Mar 01 00:00:00 EST 2006
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Cancer research
Dasgupta B,Li W,Perry A,Gutmann DH
Sat Jan 01 00:00:00 EST 2005
The cell cycle-apoptosis connection revisited in the adult brain.
The Journal of cell biology
Bauer S,Patterson PH
Mon Nov 21 00:00:00 EST 2005
Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Norris CM,Kadish I,Blalock EM,Chen KC,Thibault V,Porter NM,Landfield PW,Kraner SD
Wed May 04 00:00:00 EDT 2005
Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord.
The Journal of comparative neurology
Wicher G,Larsson M,Rask L,Aldskogius H
13-0300 was used in immunocytochemistry to elucidate the role of megalin in the developing spinal cord.
Mon Nov 14 00:00:00 EST 2005
Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.
Journal of neurophysiology
Takeuchi T,Fujinami K,Goto H,Fujita A,Taketo MM,Manabe T,Matsui M,Hata F
Sun May 01 00:00:00 EDT 2005
Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.
Experimental neurology
Herber DL,Roth LM,Wilson D,Wilson N,Mason JE,Morgan D,Gordon MN
13-0300 was used in immunohistochemistry - free floating to report that activated brain glia rapidly and transiently clear diffuse Abeta deposits but not compacted fibrillar amyloid
Mon Nov 01 00:00:00 EST 2004
Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
Oncogene
Uhlmann EJ,Apicelli AJ,Baldwin RL,Burke SP,Bajenaru ML,Onda H,Kwiatkowski D,Gutmann DH
13-0300 was used in immunohistochemistry - free floating and western blot to test if dysregulated astrocyte function due to mutations in TSC and TSC2 contribute to the pathogenesis of brain abnormalities in mice.
Thu Jun 06 00:00:00 EDT 2002
Recovery from spinal cord injury: a new transection model in the C57Bl/6 mouse.
Journal of neuroscience research
Seitz A,Aglow E,Heber-Katz E
13-0300 was used in immunohistochemistry - paraffin section to discuss spinal cord regeneration
Fri Feb 01 00:00:00 EST 2002
CNS wound healing is severely depressed in metallothionein I- and II-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Penkowa M,Carrasco J,Giralt M,Moos T,Hidalgo J
13-0300 was used in immunohistochemistry to characterize the physiological role of metallothioneins I and II in the brain after freeze injury.
Thu Apr 01 00:00:00 EST 1999
Constitutive and heat-inducible expression of HSP105 in neurons and glial cells in culture.
Neuroreport
Satoh J,Yukitake M,Kuroda Y
13-0300 was used in immunocytochemistry to determine expression of HSP105 in the newborn mouse brain.
Mon Sep 14 00:00:00 EDT 1998
Distribution of integrin-like immunoreactivity on primate brain microvasculature.
Journal of neuropathology and experimental neurology
Haring HP,Akamine BS,Habermann R,Koziol JA,Del Zoppo GJ
13-0300 was used in immunohistochemistry - frozen section to determine the integrin-like immunoreactivity of the primate brain microvasculature.
Thu Feb 01 00:00:00 EST 1996
