Proteintech

Histone H2A.X Polyclonal Antibody

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (15)

Histone H2A.X Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

Histone H2A.X Antibody (10856-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using (Product # 10856-1-AP) (Histone H2A.X antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Histone H2A.X Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Histone H2A.X Antibody in Western Blot (WB)

Histone H2A.X Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

10856-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 65 publications 65 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:50

View 22 publications 22 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

ChIP assay (ChIP)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Histone H2A.X Fusion Protein Ag1305 (1-143 aa encoded by BC013416)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSGRGKTGG KARAKAKSRS SRAGLQFPVG RVHRLLRKGH YAERVGAGAP VYLAAVLEYL TAEILELAGN AARDNKKTRI IPRHLQLAIR NDEELNKLLG GVTIAQGGVL PNIQAVLLPK KTSATVGPKA PSGGKKATQA SQEY (1-143 aa encoded by BC013416)

Target Information

Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle. In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX. The phosphorylation of H2AX can be detected by Western blotting or immunofluorescence, revealing the frequency of DSBs. The phosphatidylinositol 3-kinases have been implicated in H2AX phosphorylation, but it is unclear if ATM is the primary H2AX kinase or if other members of the family such as DNA-PK and ATR contribute in a similar manner. Structurally, H2A.x contains 143 amino acid residues. Histone H2A.X is considered a basal histone, being synthesized in G1 as well as in S-phase, and its mRNA contains polyA addition motifs and a polyA tail along with the conserved stem-loop and U7 binding sequences involved in the processing and stability of replication type histone mRNAs. There are two forms of Histone H2A.X mRNA, one about 1600 bases long and contains polyA; the other about 575 bases long, lacking polyA. The short form behaves as a replication type histone mRNA, while the longer behaves as a basal type histone mRNA. Histone H2A.X maps to the 11q23.2-q23.3 region of the human chromosome. Histone H2A.x contributes to histone-formation and therefore the structure of DNA. Histone H2A variant H2A.x specifically regulates the interaction of MDC1 (mediator of DNA damage checkpoint protein 1), a DNA repair protein to the sites of DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury.

Antioxidants (Basel, Switzerland)

Cen Y,Lou G,Qi J,Li M,Zheng M,Liu Y

Mon Jan 09 00:00:00 EST 2023

CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ.

Bone research

Yu R,Han H,Chu S,Ding Y,Jin S,Wang Y,Jiang W,Liu Y,Zou Y,Wang M,Liu Q,Sun G,Jiang B,Gong Y

Fri Jun 02 00:00:00 EDT 2023

Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair.

iScience

Yang B,Zhang W,Sun L,Lu B,Yin C,Zhang Y,Jiang H

Fri May 19 00:00:00 EDT 2023

LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.

Experimental cell research

Dong J,Ru Y,Zhai L,Gao Y,Guo X,Chen B,Lv X

Mon May 15 00:00:00 EDT 2023

Near-Infrared Phototheranostic Iron Pyrite Nanocrystals Simultaneously Induce Dual Cell Death Pathways via Enhanced Fenton Reactions in Triple-Negative Breast Cancer.

ACS nano

Zhao C,Liu Z,Chang CC,Chen YC,Zhang Q,Zhang XD,Andreou C,Pang J,Liu ZX,Wang DY,Kircher MF,Yang J

Tue Mar 14 00:00:00 EDT 2023

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhu Z,Zhou X,Du H,Cloer EW,Zhang J,Mei L,Wang Y,Tan X,Hepperla AJ,Simon JM,Cook JG,Major MB,Dotti G,Liu P

Sun Jan 01 00:00:00 EST 2023

TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.

Oncogene

Wang Y,Yao Y,Wei Q,Long S,Chen Y,Xie J,Tan R,Jiang W,Zhang Q,Wu D,Xiao S,Wan F,Fu K

Wed Feb 01 00:00:00 EST 2023

NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.

The EMBO journal

Zhao T,Zhang J,Lei H,Meng Y,Cheng H,Zhao Y,Geng G,Mu C,Chen L,Liu Q,Luo Q,Zhang C,Long Y,Su J,Wang Y,Li Z,Sun J,Chen G,Li Y,Liao X,Shang Y,Hu G,Chen Q,Zhu Y

Tue Aug 15 00:00:00 EDT 2023

4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells.

Toxicology in vitro : an international journal published in association with BIBRA

Song W,Qiu YT,Li XZ,Sun QY,Chen LN

Fri Sep 01 00:00:00 EDT 2023

4-vinylcyclohexene diepoxide induces apoptosis by excessive reactive oxygen species and DNA damage in human ovarian granulosa cells.

Toxicology in vitro : an international journal published in association with BIBRA

Song W,Qiu YT,Li XZ,Sun QY,Chen LN

Fri Sep 01 00:00:00 EDT 2023

DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Hou S,Cheng Y,Wang Z,Xia L,Wang J,Wang H,Sun J,Ma J,Yan Y

Sun Jan 01 00:00:00 EST 2023

Nanofibrillar peptide hydrogels for self-delivery of lonidamine and synergistic photodynamic therapy.

Acta biomaterialia

Wu C,Jiao Q,Wang C,Zheng Y,Pan X,Zhong W,Xu K

Sun Jan 01 00:00:00 EST 2023

Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells.

Toxicology letters

Komatsu M,Funakoshi T,Aki T,Unuma K,Uemura K

Sat Apr 01 00:00:00 EDT 2023

Immunostimulation with chemotherapy of a ruthenium-arene complex via blockading CD47 signal in chronic myelogenous leukemia cells.

Journal of inorganic biochemistry

Hu G,Lv M,Guo B,Huang Y,Su Z,Qian Y,Xue X,Liu HK

Thu Jun 01 00:00:00 EDT 2023

Olaparib, a PARP-1 inhibitor, protects retinal cells from ocular hypertension-associated oxidative damage.

Frontiers in cell and developmental biology

Yang Y,Wu J,Lu W,Dai Y,Zhang Y,Sun X

Tue Sep 13 00:00:00 EDT 2022

Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.

Cancer research

Sun Z,Zhang Z,Wang QQ,Liu JL

Tue Mar 15 00:00:00 EDT 2022

A Novel CDK4/6 and PARP Dual Inhibitor ZC-22 Effectively Suppresses Tumor Growth and Improves the Response to Cisplatin Treatment in Breast and Ovarian Cancer.

International journal of molecular sciences

Tian C,Wei Y,Li J,Huang Z,Wang Q,Lin Y,Lv X,Chen Y,Fan Y,Sun P,Xiang R,Chang A,Yang S

Mon Mar 07 00:00:00 EST 2022

Minimizing adverse effects of Cerenkov radiation induced photodynamic therapy with transformable photosensitizer-loaded nanovesicles.

Journal of nanobiotechnology

Qian R,Wang K,Guo Y,Li H,Zhu Z,Huang X,Gong C,Gao Y,Guo R,Yang B,Wang C,Jiang D,Lan X,An R,Gao Z

Wed Apr 27 00:00:00 EDT 2022

ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.

Biochemical and biophysical research communications

Hu X,Pei D,Ci M,Zhang G,Li B,Wang J,Shen Y,Zhai X,Liang P,Cui H

Sat Apr 09 00:00:00 EDT 2022

ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhou Y,Liu X,Ma S,Zhang N,Yang D,Wang L,Ye S,Zhang Q,Ruan J,Ma J,Wang S,Jiang N,Zhao Z,Zhao S,Zheng C,Fan X,Gong Y,Abdoul Razak MY,Hu W,Pan J,Wang X,Fan J,Li J,Liu R,Shentu Y

Tue Mar 01 00:00:00 EST 2022

HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.

International journal of biological sciences

Dou Z,Qiu C,Zhang X,Yao S,Zhao C,Wang Z,Chu R,Chen J,Chen Z,Li R,Wang K,Liu P,Liu C,Song K,Kong B

Fri Apr 15 00:00:00 EDT 2022

Minocycline Counteracts Ectopic Calcification in a Murine Model of Pseudoxanthoma Elasticum: A Proof-of-Concept Study.

International journal of molecular sciences

Bouderlique E,Nollet L,Letavernier E,Vanakker OM

Sun Feb 06 00:00:00 EST 2022

Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Su Y,Wu T,Yu XY,Huo WB,Wang SH,Huan C,Liu YM,Liu JM,Cui MN,Li XH,Yu JH

Sun May 01 00:00:00 EDT 2022

Real-world PM_2.5 exposure induces pathological injury and DNA damage associated with miRNAs and DNA methylation alteration in rat lungs.

Environmental science and pollution research international

Zhao L,Zhang M,Bai L,Zhao Y,Cai Z,Yung KKL,Dong C,Li R

Fri Apr 01 00:00:00 EDT 2022

AKR1B10 accelerates the production of proinflammatory cytokines via the NF-κB signaling pathway in colon cancer.

Journal of molecular histology

Liu C,Shi L,Li W,Huang Z,Wang S,Xu P,Li T,Li Z,Luo F,Li W,Yan J,Wu T

Sat Oct 01 00:00:00 EDT 2022

ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer.

Cancer letters

Zhou C,Li S,Bin K,Qin G,Pan P,Ren D,Zhao Y,Xia W,Chen J,Liu J,Wu H,Zhou Y

Fri Oct 28 00:00:00 EDT 2022

PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice.

Cardiovascular toxicology

Wu T,Tong M,Chu A,Wu K,Niu X,Zhang Z

Mon Aug 01 00:00:00 EDT 2022

2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways.

Life (Basel, Switzerland)

Tu M,Fan X,Shi J,Jing S,Xu X,Wang Y

Fri Mar 11 00:00:00 EST 2022

Heterozygous FMN2 missense variant found in a family case of premature ovarian insufficiency.

Journal of ovarian research

Li J,Peng T,Wang L,Long P,Quan R,Tan H,Zeng M,Wu X,Yang J,Xiao H,Shi X

Mon Feb 28 00:00:00 EST 2022

KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.

Nucleic acids research

Yang M,Wang C,Zhou M,Bao L,Wang Y,Kumar A,Xing C,Luo W,Wang Y

Fri Jun 24 00:00:00 EDT 2022

Taohong siwu decoction attenuates AIM2 and NLRC4 inflammasomes by ameliorates deoxyribonucleic acid damage after ischemic stroke.

Frontiers in pharmacology

Wang N,Chu F,Zhang L,Fei C,Yu C,Xue S,Wang Y,Fang L,Peng D,Duan X,Chen W

Tue Aug 30 00:00:00 EDT 2022

Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication.

Virulence

Yu J,Zhang W,Huo W,Meng X,Zhong T,Su Y,Liu Y,Liu J,Wang Z,Song F,Zhang S,Li Z,Yu X,Yu X,Hua S

Thu Dec 01 00:00:00 EST 2022

Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.

Frontiers in medicine

Wang D,Yin L,Chen R,Tan W,Liang L,Xiang J,Zhang H,Zhou X,Deng H,Guo B,Wang Y

Sat Feb 11 00:00:00 EST 2023

Hedgehog/GLI1 signaling pathway regulates the resistance to cisplatin in human osteosarcoma.

Journal of Cancer

Chen D,Kang X,Li Z,Chen L,Ma Q,Fan P

Fri Oct 22 00:00:00 EDT 2021

Photobiomodulation Therapy Attenuates Anxious-Depressive-Like Behavior in the TgF344 Rat Model.

Journal of Alzheimer's disease : JAD

Yang L,Wu C,Tucker L,Dong Y,Li Y,Xu P,Zhang Q

Thu Dec 16 00:00:00 EST 2021

Stimulation of ROS Generation by Extract of Warburgia ugandensis Leading to G₀/G₁ Cell Cycle Arrest and Antiproliferation in A549 Cells.

Antioxidants (Basel, Switzerland)

Zhang YL,Chen GL,Liu Y,Zhuang XC,Guo MQ

Thu Sep 30 00:00:00 EDT 2021

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

International journal of biological sciences

Wang CM,Li HF,Wang XK,Li WG,Su Q,Xiao X,Hao TF,Chen W,Zhang YW,Zhang HY,Wu W,Hu ZR,Zhao GY,Huo MY,He YL,Zhang CH

Thu Mar 17 00:00:00 EDT 2022

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

International journal of biological sciences

Wang CM,Li HF,Wang XK,Li WG,Su Q,Xiao X,Hao TF,Chen W,Zhang YW,Zhang HY,Wu W,Hu ZR,Zhao GY,Huo MY,He YL,Zhang CH

Thu Mar 17 00:00:00 EDT 2022

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

International journal of biological sciences

Wang CM,Li HF,Wang XK,Li WG,Su Q,Xiao X,Hao TF,Chen W,Zhang YW,Zhang HY,Wu W,Hu ZR,Zhao GY,Huo MY,He YL,Zhang CH

Thu Mar 17 00:00:00 EDT 2022

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

International journal of biological sciences

Wang CM,Li HF,Wang XK,Li WG,Su Q,Xiao X,Hao TF,Chen W,Zhang YW,Zhang HY,Wu W,Hu ZR,Zhao GY,Huo MY,He YL,Zhang CH

Thu Mar 17 00:00:00 EDT 2022

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

International journal of biological sciences

Wang CM,Li HF,Wang XK,Li WG,Su Q,Xiao X,Hao TF,Chen W,Zhang YW,Zhang HY,Wu W,Hu ZR,Zhao GY,Huo MY,He YL,Zhang CH

Thu Mar 17 00:00:00 EDT 2022

Ailanthus Altissima-derived Ailanthone enhances Gastric Cancer Cell Apoptosis by Inducing the Repression of Base Excision Repair by Downregulating p23 Expression.

International journal of biological sciences

Wang CM,Li HF,Wang XK,Li WG,Su Q,Xiao X,Hao TF,Chen W,Zhang YW,Zhang HY,Wu W,Hu ZR,Zhao GY,Huo MY,He YL,Zhang CH

Thu Mar 17 00:00:00 EDT 2022

MiR-320b/RAD21 axis affects hepatocellular carcinoma radiosensitivity to ionizing radiation treatment through DNA damage repair signaling.

Cancer science

Wang J,Zhao H,Yu J,Xu X,Jing H,Li N,Tang Y,Wang S,Li Y,Cai J,Jin J

Mon Feb 01 00:00:00 EST 2021

The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress.

Oxidative medicine and cellular longevity

Tian J,Wang Y,Ding M,Zhang Y,Chi J,Wang T,Jiao B,Jian Z,Yi X,Huang Y,Liu L,Li K,Chen J,Wang G,Gao T,Li C,Li Q

Thu Feb 17 00:00:00 EST 2022

Identification of Potential Prognostic Biomarker for Predicting Survival in Multiple Myeloma Using Bioinformatics Analysis and Experiments.

Frontiers in genetics

Zhou J,Zhang M,Zhang Y,Shi X,Liu L,Yao R

Wed Sep 29 00:00:00 EDT 2021

ZMYND8 Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth.

Cancer research

Wang Y,Luo M,Chen Y,Wang Y,Zhang B,Ren Z,Bao L,Wang Y,Wang JE,Fu YX,Luo W,Wang Y

Fri Jan 01 00:00:00 EST 2021

DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.

Oncology reports

Luo W,Zhang H,Liang X,Xia R,Deng H,Yi Q,Lv L,Qian L

Fri May 01 00:00:00 EDT 2020

5-(3,4,5-trimethoxybenzoyl)-4-methyl-2-(p-tolyl) imidazol (BZML) targets tubulin and DNA to induce anticancer activity and overcome multidrug resistance in colorectal cancer cells.

Chemico-biological interactions

Bai Z,Liu X,Guan Q,Ding N,Wei Q,Tong B,Zhao M,Zhang W,Ma L

Sun Jan 05 00:00:00 EST 2020

Telomere dysfunction activates YAP1 to drive tissue inflammation.

Nature communications

Chakravarti D,Hu B,Mao X,Rashid A,Li J,Li J,Liao WT,Whitley EM,Dey P,Hou P,LaBella KA,Chang A,Wang G,Spring DJ,Deng P,Zhao D,Liang X,Lan Z,Lin Y,Sarkar S,Terranova C,Deribe YL,Blutt SE,Okhuysen P,Zhang J,Vilar E,Nielsen OH,Dupont A,Younes M,Patel KR,Shroyer NF,Rai K,Estes MK,Wang YA,Bertuch AA,DePinho RA

Mon Sep 21 00:00:00 EDT 2020

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Aging

Zou K,Li Z,Zhang Y,Mu L,Chen M,Wang R,Deng W,Zou L,Liu J

Wed Dec 09 00:00:00 EST 2020

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Aging

Zou K,Li Z,Zhang Y,Mu L,Chen M,Wang R,Deng W,Zou L,Liu J

Wed Dec 09 00:00:00 EST 2020

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Aging

Zou K,Li Z,Zhang Y,Mu L,Chen M,Wang R,Deng W,Zou L,Liu J

Wed Dec 09 00:00:00 EST 2020

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Cell proliferation

Ju JQ,Li XH,Pan MH,Xu Y,Sun MH,Xu Y,Sun SC

Thu Oct 01 00:00:00 EDT 2020

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Cell proliferation

Ju JQ,Li XH,Pan MH,Xu Y,Sun MH,Xu Y,Sun SC

Thu Oct 01 00:00:00 EDT 2020

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Cell proliferation

Ju JQ,Li XH,Pan MH,Xu Y,Sun MH,Xu Y,Sun SC

Thu Oct 01 00:00:00 EDT 2020

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Cell proliferation

Ju JQ,Li XH,Pan MH,Xu Y,Sun MH,Xu Y,Sun SC

Thu Oct 01 00:00:00 EDT 2020

Promotion effects of mono-2-ethyhexyl phthalate (MEHP) on migration and invasion of human melanoma cells via activation of TGF-β signals.

Cell biochemistry and function

Fan P,Li Z,Zuo C,Fang M

Wed Jan 01 00:00:00 EST 2020

Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting.

Theranostics

Ren L,Feng W,Shao J,Ma J,Xu M,Zhu BZ,Zheng N,Liu S

Wed Apr 28 00:00:00 EDT 2021

A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.

Journal of cellular and molecular medicine

Jia Y,Jin H,Gao L,Yang X,Wang F,Ding H,Chen A,Tan S,Zhang F,Shao J,Wang S,Zheng S

Fri May 01 00:00:00 EDT 2020

A Heterojunction Structured WO_2.9-WSe₂ Nanoradiosensitizer Increases Local Tumor Ablation and Checkpoint Blockade Immunotherapy upon Low Radiation Dose.

ACS nano

Dong X,Cheng R,Zhu S,Liu H,Zhou R,Zhang C,Chen K,Mei L,Wang C,Su C,Liu X,Gu Z,Zhao Y

Tue May 26 00:00:00 EDT 2020

Ginsenoside Rb1 Ameliorates Age-Related Myocardial Dysfunction by Regulating the NF-[Formula: see text]B Signaling Pathway.

The American journal of Chinese medicine

Ke SY,Liu DH,Wu L,Yu XG,Wang M,Shi GY,Wen RH,Zhou B,Hao BS,Liu Y,Zhu JM,Qian XX

Wed Oct 21 00:00:00 EDT 2020

Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement.

Biomaterials

Zhou R,Wang H,Yang Y,Zhang C,Dong X,Du J,Yan L,Zhang G,Gu Z,Zhao Y

Tue Jan 01 00:00:00 EST 2019

Tumor microenvironment-manipulated radiocatalytic sensitizer based on bismuth heteropolytungstate for radiotherapy enhancement.

Biomaterials

Zhou R,Wang H,Yang Y,Zhang C,Dong X,Du J,Yan L,Zhang G,Gu Z,Zhao Y

Tue Jan 01 00:00:00 EST 2019

Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer.

Cellular and molecular gastroenterology and hepatology

Currey N,Jahan Z,Caldon CE,Tran PN,Benthani F,De Lacavalerie P,Roden DL,Gloss BS,Campos C,Bean EG,Bullman A,Reibe-Pal S,Dinger ME,Febbraio MA,Clarke SJ,Dahlstrom JE,Kohonen-Corish MRJ

Fri Jan 17 00:00:00 EST 2020

Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane.

Theranostics

Xu X,Wang D,Zheng C,Gao B,Fan J,Cheng P,Liu B,Yang L,Luo Z

Mon Jun 29 00:00:00 EDT 2020

Conditioned medium derived from human amniotic stem cells delays H2O2‑induced premature senescence in human dermal fibroblasts.

International journal of molecular medicine

Pan C,Lang H,Zhang T,Wang R,Lin X,Shi P,Zhao F,Pang X

Fri Nov 01 00:00:00 EDT 2019

Single-Cell RNA Transcriptome Helps Define the Limbal/Corneal Epithelial Stem/Early Transit Amplifying Cells and How Autophagy Affects This Population.

Investigative ophthalmology & visual science

Kaplan N,Wang J,Wray B,Patel P,Yang W,Peng H,Lavker RM

Thu Aug 01 00:00:00 EDT 2019

Extremely Effective Chemoradiotherapy by Inducing Immunogenic Cell Death and Radio-Triggered Drug Release under Hypoxia Alleviation.

ACS applied materials & interfaces

Zhu C,Guo X,Luo L,Wu Z,Luo Z,Jiang M,Zhang J,Qin B,Shi Y,Lou Y,Qiu Y,You J

Wed Dec 18 00:00:00 EST 2019

EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway.

Bioscience reports

Zhou X,Zheng J,Tang Y,Lin Y,Wang L,Li Y,Liu C,Wu D,Cai L

Mon Sep 30 00:00:00 EDT 2019

Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.

Cell proliferation

Bai Z,Gao M,Xu X,Zhang H,Xu J,Guan Q,Wang Q,Du J,Li Z,Zuo D,Zhang W,Wu Y

Wed Aug 01 00:00:00 EDT 2018

Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.

Cell proliferation

Bai Z,Gao M,Xu X,Zhang H,Xu J,Guan Q,Wang Q,Du J,Li Z,Zuo D,Zhang W,Wu Y

Wed Aug 01 00:00:00 EDT 2018

Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.

Cellular and molecular neurobiology

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Sun Apr 01 00:00:00 EDT 2018

Role of Peroxiredoxin 2 in the Protection Against Ferrous Sulfate-Induced Oxidative and Inflammatory Injury in PC12 Cells.

Cellular and molecular neurobiology

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Sun Apr 01 00:00:00 EDT 2018

The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria.

Infection and immunity

Liu Q,Zhao Y,Zheng L,Zhu X,Cui L,Cao Y

Wed Aug 01 00:00:00 EDT 2018

The Glycosylphosphatidylinositol Transamidase Complex Subunit PbGPI16 of Plasmodium berghei Is Important for Inducing Experimental Cerebral Malaria.

Infection and immunity

Liu Q,Zhao Y,Zheng L,Zhu X,Cui L,Cao Y

Wed Aug 01 00:00:00 EDT 2018

Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.

FEBS open bio

Hong F,Wan L,Liu J,Huang K,Xiao Z,Zhang Y,Shi C

Thu Mar 01 00:00:00 EST 2018

Histone methylation regulates Hif-1 signaling cascade in activation of hepatic stellate cells.

FEBS open bio

Hong F,Wan L,Liu J,Huang K,Xiao Z,Zhang Y,Shi C

Thu Mar 01 00:00:00 EST 2018

Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway.

Scientific reports

Zhou L,Wang H,Jing J,Yu L,Wu X,Lu Z

Thu Sep 13 00:00:00 EDT 2018

Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway.

Scientific reports

Zhou L,Wang H,Jing J,Yu L,Wu X,Lu Z

Thu Sep 13 00:00:00 EDT 2018

Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.

Cancer medicine

Chen X,Wu L,Li D,Xu Y,Zhang L,Niu K,Kong R,Gu J,Xu Z,Chen Z,Sun J

Wed Aug 01 00:00:00 EDT 2018

Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.

Cancer medicine

Chen X,Wu L,Li D,Xu Y,Zhang L,Niu K,Kong R,Gu J,Xu Z,Chen Z,Sun J

Wed Aug 01 00:00:00 EDT 2018

Lead Induces Genotoxicity via Oxidative Stress and Promoter Methylation of DNA Repair Genes in Human Lymphoblastoid TK6 Cells.

Medical science monitor : international medical journal of experimental and clinical research

Liu X,Wu J,Shi W,Shi W,Liu H,Wu X

Fri Jun 22 00:00:00 EDT 2018

Lead Induces Genotoxicity via Oxidative Stress and Promoter Methylation of DNA Repair Genes in Human Lymphoblastoid TK6 Cells.

Medical science monitor : international medical journal of experimental and clinical research

Liu X,Wu J,Shi W,Shi W,Liu H,Wu X

Fri Jun 22 00:00:00 EDT 2018

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.

ACS nano

Yong Y,Zhang C,Gu Z,Du J,Guo Z,Dong X,Xie J,Zhang G,Liu X,Zhao Y

Tue Jul 25 00:00:00 EDT 2017

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.

ACS nano

Yong Y,Zhang C,Gu Z,Du J,Guo Z,Dong X,Xie J,Zhang G,Liu X,Zhao Y

Tue Jul 25 00:00:00 EDT 2017

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.

ACS nano

Yong Y,Zhang C,Gu Z,Du J,Guo Z,Dong X,Xie J,Zhang G,Liu X,Zhao Y

Tue Jul 25 00:00:00 EDT 2017

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.

ACS nano

Yong Y,Zhang C,Gu Z,Du J,Guo Z,Dong X,Xie J,Zhang G,Liu X,Zhao Y

Tue Jul 25 00:00:00 EDT 2017

Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.

ACS nano

Yong Y,Zhang C,Gu Z,Du J,Guo Z,Dong X,Xie J,Zhang G,Liu X,Zhao Y

Tue Jul 25 00:00:00 EDT 2017

Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.

Free radical biology & medicine

Mikuła-Pietrasik J,Uruski P,Pakuła M,Maksin K,Szubert S,Woźniak A,Naumowicz E,Szpurek D,Tykarski A,Książek K

Fri Sep 01 00:00:00 EDT 2017

Oxidative stress contributes to hepatocyte growth factor-dependent pro-senescence activity of ovarian cancer cells.

Free radical biology & medicine

Mikuła-Pietrasik J,Uruski P,Pakuła M,Maksin K,Szubert S,Woźniak A,Naumowicz E,Szpurek D,Tykarski A,Książek K

Fri Sep 01 00:00:00 EDT 2017

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Journal of agricultural and food chemistry

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J,Zhou Z

Wed Jul 26 00:00:00 EDT 2017

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Journal of agricultural and food chemistry

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J,Zhou Z

Wed Jul 26 00:00:00 EDT 2017

Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.

Chemico-biological interactions

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Tue Aug 01 00:00:00 EDT 2017

Tert-butylhydroquinone protects PC12 cells against ferrous sulfate-induced oxidative and inflammatory injury via the Nrf2/ARE pathway.

Chemico-biological interactions

Xu W,Li F,Xu Z,Sun B,Cao J,Liu Y

Tue Aug 01 00:00:00 EDT 2017

Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Tang Q,Ji F,Wang J,Guo L,Li Y,Bao Y

Wed Nov 15 00:00:00 EST 2017

Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Tang Q,Ji F,Wang J,Guo L,Li Y,Bao Y

Wed Nov 15 00:00:00 EST 2017

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Plant foods for human nutrition (Dordrecht, Netherlands)

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J

Fri Dec 01 00:00:00 EST 2017

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Plant foods for human nutrition (Dordrecht, Netherlands)

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J

Fri Dec 01 00:00:00 EST 2017

The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes.

The Journal of biological chemistry

Zhao H,Han Z,Liu X,Gu J,Tang F,Wei G,Jin Y

Fri May 19 00:00:00 EDT 2017

The chromatin remodeler Chd4 maintains embryonic stem cell identity by controlling pluripotency- and differentiation-associated genes.

The Journal of biological chemistry

Zhao H,Han Z,Liu X,Gu J,Tang F,Wei G,Jin Y

Fri May 19 00:00:00 EDT 2017

MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells.

Cancer cell international

Huang D,Bian G,Pan Y,Han X,Sun Y,Wang Y,Shen G,Cheng M,Fang X,Hu S

Fri Mar 11 00:00:00 EST 2022

Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.

Radiation research