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Product Details
PA5-75527
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 762-807 of Human KCNH1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719255
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH1 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH1 is activated at the onset of myoblast differentiation. KCNH1 is highly expressed in brain and in myoblasts. Overexpression of KCNH1 may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of KCNH1 results in two transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAG channel 1; EAG1; ether a go-go; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; potassium channel, voltage gated eag related subfamily H, member 1; Potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; r-eag; Voltage-gated delayed rectifier potassium channel KCNH1; Voltage-gated potassium channel subunit Kv10.1
Gene Aliases: EAG; EAG1; h-eag; hEAG1; KCNH1; Kv10.1; M-eag; TMBTS; ZLS1
UniProt ID: (Human) O95259, (Rat) Q63472, (Mouse) Q60603
Entrez Gene ID: (Human) 3756, (Rat) 65198, (Mouse) 16510
phosphorelay sensor kinase activity
delayed rectifier potassium channel activity
protein binding
calmodulin binding
protein kinase binding
cyclic nucleotide binding
identical protein binding
ion channel binding
protein heterodimerization activity
14-3-3 protein binding
voltage-gated potassium channel activity
signal transducer activity
ion channel activity
voltage-gated ion channel activity
potassium channel activity
ion channel
phosphorelay signal transduction system
startle response
potassium ion transport
myoblast fusion
signal transduction by protein phosphorylation
regulation of ion transmembrane transport
regulation of cell proliferation
regulation of membrane potential
cellular response to calcium ion
potassium ion transmembrane transport
ion transmembrane transport
transport
ion transport
signal transduction
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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