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Antibody detects endogenous levels of total NACAD.
May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NAC-alpha domain-containing protein 1
Gene Aliases: KIAA0363; NACAD
UniProt ID: (Human) O15069
Entrez Gene ID: (Human) 23148
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