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Product Details
BS-6855R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NALP4, amino acids 351-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-a and IL-1-b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappa-B activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cancer/testis antigen 58; CT58; NACHT, leucine rich repeat and PYD containing 4; NACHT, leucine rich repeat and PYD containing 4A; NACHT, leucine rich repeat and PYD containing 4E; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NACHT, LRR and PYD domains-containing protein 4A; NACHT, LRR and PYD domains-containing protein 4E; NACHT/LRR/pyrin domain-containing protein 4; NALP, epsilon; NALP-epsilon; NALP-ita; NLR family, pyrin domain containing 4; NLR family, pyrin domain containing 4E; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2
Gene Aliases: 4930406H16Rik; CLR19.5; CT58; E330021B02; E330028A19Rik; Nalp-epsilon; Nalp-eta; Nalp-ita; NALP4; Nalp4a; Nalp4e; NLRP4; Nlrp4a; Nlrp4e; PAN2; PYPAF4; RGD1561918; RGD1563529; RNH2
UniProt ID: (Human) Q96MN2, (Mouse) Q8BU40, (Mouse) Q66X19
Entrez Gene ID: (Human) 147945, (Rat) 499069, (Rat) 292545, (Mouse) 243880, (Mouse) 446099
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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