Proteintech

NDUFS1 Polyclonal Antibody

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Antibody Testing Data (14)

NDUFS1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 14

NDUFS1 Antibody (12444-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA) fixed HeLa cells stained for NDUFS1 rabbit pAb (12444-1-AP) at dilution of 1:50 and alpha Tubulin mouse mAb (66031-1-IG) at dilution of 1:100, further stained with Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) for 12444-1-AP, and Alexa Fluor 594-conjugated AffiniPure Goat Anti-mouse IGG (H+L) for 66031-1-IG.

NDUFS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NDUFS1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12444-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 56 publications 56 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NDUFS1 Fusion Protein Ag3135 (1-305 aa encoded by BC030833)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLRIPVRKA LVGLSKSPKG CVRTTATAAS NLIEVFVDGQ SVMVEPGTTV LQACEKVGMQ IPRFCYHERL SVAGNCRMCL VEIEKAPKVV AACAMPVMKG WNILTNSEKS KKAREGVMEF LLANHPLDCP ICDQGGECDL QDQSMMFGND RSRFLEGKRA VEDKNIGPLV KTIMTRCIQC TRCIRFASEI AGVDDLGTTG RGNDMQVGTY IEKMFMSELS GNIIDICPVG ALTSKPYAFT AQPWETRKTE SIDVMDAVGS NIVVSTRTGE VMRILPRMHE DINEEWISDK TRFAYDGLKR QRLTEP (1-305 aa encoded by B C030833)

Target Information

The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

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Assembly factors for the membrane arm of human complex I.

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Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults.

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Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults.

Nature neuroscience

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Sun Sep 04 00:00:00 EDT 2011

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults.

Nature neuroscience

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Sun Sep 04 00:00:00 EDT 2011

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults.

Nature neuroscience

Alvarez-Fischer D,Fuchs J,Castagner F,Stettler O,Massiani-Beaudoin O,Moya KL,Bouillot C,Oertel WH,Lombès A,Faigle W,Joshi RL,Hartmann A,Prochiantz A

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Apoptosis-inducing factor is a target gene of C/EBPα and participates in adipocyte differentiation.

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Bioinformatics

Protein Aliases: CI-75kD; complex I 75kDa subunit; complex I, mitochondrial respiratory chain, 75-kD subunit; Complex I-75kD; MGC26839; mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase); NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; NDUFS-1; OTTHUMP00000206345

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Gene Aliases: 5830412M15Rik; 9930026A05Rik; CI-75k; CI-75Kd; NDUFS1; PRO1304

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UniProt ID: (Human) P28331, (Rat) Q66HF1, (Mouse) Q91VD9

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Entrez Gene ID: (Human) 4719, (Rat) 301458, (Mouse) 227197

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Function(s)

protein binding NADH dehydrogenase (ubiquinone) activity electron carrier activity metal ion binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding molecular_function NADH dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H iron-sulfur cluster binding reductase

Process(es)

mitochondrial electron transport, NADH to ubiquinone apoptotic mitochondrial changes mitochondrial respiratory chain complex I assembly cellular respiration ATP metabolic process regulation of mitochondrial membrane potential reactive oxygen species metabolic process biological_process ATP synthesis coupled electron transport transport oxidation-reduction process

Performance Guarantee

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NDUFS1 Polyclonal Antibody

NDUFS1 Antibody (12444-1-AP) in ICC/IF

Product Details

12444-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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