Product References
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
Antioxidants (Basel, Switzerland)
Qiao P,Sun Y,Wang Y,Lin S,An Y,Wang L,Liu J,Huang Y,Yang B,Zhou H
Fri Apr 28 00:00:00 EDT 2023
Ginsenoside Rh2 inhibits CBP/p300-mediated FOXO3a acetylation and epilepsy-induced oxidative damage via the FOXO3a-KEAP1-NRF2 pathway.
European journal of pharmacology
Wu J,Wang S,Zhao W,Li M,Li S
Sun Feb 05 00:00:00 EST 2023
HMSCs exosome-derived miR-199a-5p attenuates sulfur mustard-associated oxidative stress via the CAV1/NRF2 signalling pathway.
Journal of cellular and molecular medicine
Gong C,Gu Z,Zhang X,Xu Q,Mao G,Pei Z,Meng W,Cen J,Liu J,He X,Sun M,Xiao K
Tue Aug 01 00:00:00 EDT 2023
Effects of protocatechuic acid on antioxidant capacity, mitochondrial biogenesis and skeletal muscle fiber transformation.
The Journal of nutritional biochemistry
Yang L,Chen X,Chen D,Yu B,He J,Luo Y,Zheng P,Chen H,Yan H,Huang Z
Thu Jun 01 00:00:00 EDT 2023
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling.
Molecular medicine (Cambridge, Mass.)
Xu L,Cai J,Li C,Yang M,Duan T,Zhao Q,Xi Y,Sun L,He L,Tang C,Sun L
Mon Apr 24 00:00:00 EDT 2023
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.
Toxicology letters
Hou Z,Yan M,Li H,Wang W,You S,Wang M,Du T,Gong H,Li W,Guo L,Wei S,Zhang B,Ji M,Chen X
Sat Apr 15 00:00:00 EDT 2023
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
EBioMedicine
Wang Y,Tang B,Li H,Zheng J,Zhang C,Yang Z,Tan X,Luo P,Ma L,Wang Y,Long L,Chen Z,Xiao Z,Ma L,Zhou J,Wang Y,Shi C
Sat Apr 01 00:00:00 EDT 2023
Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis.
Antioxidants (Basel, Switzerland)
Zhang X,Cui K,Wang X,Tong Y,Liu C,Zhu Y,You Q,Jiang Z,Guo X
Mon May 08 00:00:00 EDT 2023
Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation.
Journal of ethnopharmacology
Wang SJ,Ye W,Li WY,Tian W,Zhang M,Sun Y,Feng YD,Liu CX,Liu SY,Cao W,Meng JR,Li XQ
Wed Mar 01 00:00:00 EST 2023
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Frontiers in pharmacology
Chen T,Hu Y,Lu L,Zhao Q,Tao X,Ding B,Chen S,Zhu J,Guo X,Lin Z
Tue Mar 28 00:00:00 EDT 2023
Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells.
Toxicology letters
Komatsu M,Funakoshi T,Aki T,Unuma K,Uemura K
Sat Apr 01 00:00:00 EDT 2023
Elsholtzia bodinieri Vaniot ameliorated acute lung injury in mice by regulating pyroptosis, inflammation, oxidative stress and macrophage polarization.
Journal of ethnopharmacology
Jiang X,Sun J,Guo S,Zhao Z,Chen Y,Cao J,Liu Y,Cheng G,Tian L,Li Y
Wed May 10 00:00:00 EDT 2023
Apple polyphenols improve intestinal barrier function by enhancing antioxidant capacity and suppressing inflammation in weaning piglets.
Animal science journal = Nihon chikusan Gakkaiho
Guo Z,Chen X,Huang Z,Chen D,Yu J,Yan H,Chen H,He J,Zheng P,Luo Y,Yu B
Thu Jun 16 00:00:00 EDT 2022
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.
Acta pharmacologica Sinica
Li JW,Wang RL,Xu J,Sun KY,Jiang HM,Sun ZY,Lv ZY,Xu XQ,Wu R,Guo H,Jiang Q,Shi DQ
Tue Feb 01 00:00:00 EST 2022
Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway.
European journal of pharmacology
Wang L,Zeng YQ,Gu JH,Song R,Cang PH,Xu YX,Shao XX,Pu LJ,Luo HY,Zhou XF
Tue Apr 05 00:00:00 EDT 2022
Dietary L-theanine supplementation improves lipid metabolism and antioxidant capacity in weaning piglets.
Animal biotechnology
Chen X,Chen L,Qin Y,Mao Z,Huang Z,Jia G,Zhao H,Liu G
Thu Dec 01 00:00:00 EST 2022
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in vivo.
The Journal of nutritional biochemistry
Chen X,Zhang M,Xue Y,Liang D,An W,Jia G,Zhao H,Liu G,Huang Z
Sat Jan 01 00:00:00 EST 2022
Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.
Experimental and therapeutic medicine
Wang WX,Zhao ZR,Bai Y,Li YX,Gao XN,Zhang S,Sun YB
Fri Apr 01 00:00:00 EDT 2022
Sevoflurane preconditioning prevents acute renal injury caused by ischemia-reperfusion in mice via activation of the Nrf2 signaling pathway.
Experimental and therapeutic medicine
Wang WX,Zhao ZR,Bai Y,Li YX,Gao XN,Zhang S,Sun YB
Fri Apr 01 00:00:00 EDT 2022
Realgar-induced nephrotoxicity via ferroptosis in mice.
Journal of applied toxicology : JAT
Zhang S,Cao S,Zhou H,Li L,Hu Q,Mao X,Ji S
Tue Nov 01 00:00:00 EDT 2022
Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.
Cells
Alannan M,Fatrouni H,Trézéguet V,Dittrich-Domergue F,Moreau P,Siegfried G,Liet B,Khatib AM,Grosset CF,Badran B,Fayyad-Kazan H,Merched AJ
Fri Dec 23 00:00:00 EST 2022
Salvianolate ameliorates renal tubular injury through the Keap1/Nrf2/ARE pathway in mouse kidney ischemia-reperfusion injury.
Journal of ethnopharmacology
Sun D,Cui S,Ma H,Zhu P,Li N,Zhang X,Zhang L,Xuan L,Li J
Fri Jul 15 00:00:00 EDT 2022
Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation.
The Journal of nutritional biochemistry
Xie K,Li Y,He G,Zhao X,Chen D,Yu B,Luo Y,Mao X,Huang Z,Yu J,Luo J,Zheng P,Yan H,Li H,He J
Thu Dec 01 00:00:00 EST 2022
Dual antioxidant activity and the related mechanisms of a novel pentapeptide GLP4 from the fermented mycelia of Ganoderma lingzhi.
Food & function
Huang P,Luo FJ,Ma YC,Wang SX,Huang J,Qin DD,Xue FF,Liu BY,Wu Q,Wang XL,Liu GQ
Tue Aug 30 00:00:00 EDT 2022
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Journal of agricultural and food chemistry
Du L,Hao YM,Yang YH,Zheng Y,Wu ZJ,Zhou MQ,Wang BZ,Wang YM,Wu H,Su GH
Wed Mar 09 00:00:00 EST 2022
Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway.
Evidence-based complementary and alternative medicine : eCAM
Sun H,Wang J,Bi W,Zhang F,Chi K,Shi L,Yuan T,Ma K,Gao X
Thu Dec 14 00:00:00 EST 2023
Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.
Cell death & disease
Ni L,Xiao J,Zhang D,Shao Z,Huang C,Wang S,Wu Y,Tian N,Sun L,Wu A,Zhou Y,Wang X,Zhang X
Thu Feb 10 00:00:00 EST 2022
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Antioxidants (Basel, Switzerland)
Wang K,Tang Y,Wu X,Liang H,Chen D,Yu B,He J,Mao X,Huang Z,Yan H,Wu A,Luo Y,Zheng P,Yu J,Wang H,Luo J
Sun Sep 18 00:00:00 EDT 2022
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Li S,Ma Y,Ye S,Su Y,Hu D,Xiao F
Wed Jun 01 00:00:00 EDT 2022
Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4.
Stem cell research & therapy
Sun F,Sun Y,Zhu J,Wang X,Ji C,Zhang J,Chen S,Yu Y,Xu W,Qian H
Fri Jul 15 00:00:00 EDT 2022
Effect of dietary L-theanine supplementation on skeletal muscle fiber type transformation in weaning piglets.
Animal biotechnology
Chen X,Chen L,Qin Y,Mao Z,Jia G,Zhao H,Liu G,Huang Z
Thu Dec 01 00:00:00 EST 2022
Dihydromyricetin Enhances Intestinal Antioxidant Capacity of Growing-Finishing Pigs by Activating ERK/Nrf2/HO-1 Signaling Pathway.
Antioxidants (Basel, Switzerland)
Wei C,Chen X,Chen D,Yu B,Zheng P,He J,Chen H,Yan H,Luo Y,Huang Z
Sat Apr 02 00:00:00 EDT 2022
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Oxidative medicine and cellular longevity
Han GJ,Min XZ,Ma SS,Ding C,Wang XQ
Tue Dec 20 00:00:00 EST 2022
Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.
Biochemical and biophysical research communications
Zhou Z,Li H,Bai S,Xu Z,Jiao Y
Sat Apr 16 00:00:00 EDT 2022
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Bioorganic & medicinal chemistry
Wang W,Xiong L,Li Y,Song Z,Sun D,Li H,Chen L
Tue Feb 15 00:00:00 EST 2022
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Biochemistry and cell biology = Biochimie et biologie cellulaire
Zhou W,Dong G,Gao G,He Z,Xu J,Aziz S,Ma L,Zhao W
Mon Aug 01 00:00:00 EDT 2022
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Biochemical pharmacology
Ni L,Lin Z,Hu S,Shi Y,Jiang Z,Zhao J,Zhou Y,Wu Y,Tian N,Sun L,Wu A,Pan Z,Zhang X,Wang X
Fri Apr 01 00:00:00 EDT 2022
Apple Polyphenols Improve Intestinal Antioxidant Capacity and Barrier Function by Activating the Nrf2/Keap1 Signaling Pathway in a Pig Model.
Journal of agricultural and food chemistry
Huang T,Che Q,Chen X,Chen D,Yu B,He J,Chen H,Yan H,Zheng P,Luo Y,Huang Z
Wed Jun 22 00:00:00 EDT 2022
Procyanidins inhibit zearalenone-induced apoptosis and oxidative stress of porcine testis cells through activation of Nrf2 signaling pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yan R,Wang H,Zhu J,Wang T,Nepovimova E,Long M,Li P,Kuca K,Wu W
Fri Jul 01 00:00:00 EDT 2022
Elsholtzia bodinieri Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses.
International journal of molecular sciences
Sun J,Jiang X,Chen Y,Guo S,Zhao Z,Cao J,Liu Y,Cheng G,Li Y,Tian L
Fri Dec 09 00:00:00 EST 2022
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
International immunopharmacology
Huo K,Ma KG,Guo QY,Duan P,Xu J
Fri Jul 01 00:00:00 EDT 2022
Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway.
Frontiers in molecular neuroscience
Du H,Zhou X,Shi L,Xia M,Wang Y,Guo N,Hu H,Zhang P,Yang H,Zhu F,Teng Z,Liu C,Zhao M
Wed Mar 16 00:00:00 EDT 2022
Using Collagen Peptides From the Skin of Monkfish (Lophius litulon) to Ameliorate Kidney Damage in High-Fat Diet Fed Mice by Regulating the Nrf2 Pathway and NLRP3 Signaling.
Frontiers in nutrition
Miao B,Zheng J,Zheng G,Tian X,Zhang W,Yuan F,Yang Z
Mon May 02 00:00:00 EDT 2022
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
Frontiers in pharmacology
Guo K,Liu R,Jing R,Wang L,Li X,Zhang K,Fu M,Ye J,Hu Z,Zhao W,Xu N
Fri Nov 18 00:00:00 EST 2022
Dietary ferulic acid supplementation improves intestinal antioxidant capacity and intestinal barrier function in weaned piglets.
Animal biotechnology
Chen X,Wang Y,Chen D,Yu B,Huang Z
Fri Apr 01 00:00:00 EDT 2022
Monkfish (Lophius litulon) Peptides Ameliorate High-Fat-Diet-Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation via Regulation of Intestinal Flora.
Molecules (Basel, Switzerland)
Ren X,Miao B,Cao H,Tian X,Shen L,Yang Z,Yuan F,Ding Y
Wed Dec 28 00:00:00 EST 2022
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
Journal of ethnopharmacology
Zhen D,Liu C,Huang T,Fu D,Bai X,Ma Q,Jiang M,Gong G
Wed Oct 05 00:00:00 EDT 2022
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo.
International journal of molecular sciences
Shi K,Xiao Y,Dong Y,Wang D,Xie Y,Tu J,Xu K,Zhou Z,Cao G,Liu Y
Sat Dec 17 00:00:00 EST 2022
Limonin Inhibits IL-1β-Induced Inflammation and Catabolism in Chondrocytes and Ameliorates Osteoarthritis by Activating Nrf2.
Oxidative medicine and cellular longevity
Jin J,Lv X,Wang B,Ren C,Jiang J,Chen H,Chen X,Gu M,Pan Z,Tian N,Wu A,Sun L,Gao W,Wang X,Zhang X,Wu Y,Zhou Y
Mon Feb 07 00:00:00 EST 2022
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Oxidative medicine and cellular longevity
Liu J,Wu Q,Yang T,Yang F,Guo T,Zhou Y,Han S,Luo Y,Guo T,Luo F,Lin Q
Fri Feb 04 00:00:00 EST 2022
miR-98-5p protects against cerebral ischemia/reperfusion injury through anti-apoptosis and anti-oxidative stress in mice.
Journal of biochemistry
Yu S,Zhai J,Yu J,Yang Q,Yang J
Fri Mar 05 00:00:00 EST 2021
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Journal of agricultural and food chemistry
Zhang Q,Su G,Yang Q,Wei Z,Wang J,Zheng L,Zhao M
Wed Sep 15 00:00:00 EDT 2021
Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro.
Molecules (Basel, Switzerland)
Chen J,Chen Y,Zheng Y,Zhao J,Yu H,Zhu J,Li D
Mon Sep 13 00:00:00 EDT 2021
Dietary dihydromyricetin supplementation enhances antioxidant capacity and improves lipid metabolism in finishing pigs.
Food & function
Guo Z,Chen X,Huang Z,Chen D,Yu B,Chen H,Yu J,Yan H,Zheng P,Luo Y
Mon Aug 02 00:00:00 EDT 2021
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Food science & nutrition
Chen Y,Liang J,Liang X,Chen J,Wang Y,Cao J,Sun C,Ye J,Chen Q
Thu Apr 01 00:00:00 EDT 2021
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Oxidative medicine and cellular longevity
Ni B,Pei W,Qu Y,Zhang R,Chu X,Wang Y,Huang X,You H
Mon Feb 14 00:00:00 EST 2022
A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway.
Bioorganic chemistry
Tan Q,Fang Y,Peng X,Zhou H,Xu J,Gu Q
Fri Oct 01 00:00:00 EDT 2021
Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.
International immunopharmacology
Zhu Z,Hu R,Li J,Xing X,Chen J,Zhou Q,Sun J
Thu Jul 01 00:00:00 EDT 2021
Cyanidin-3-O-glucoside and its metabolite protocatechuic acid ameliorate 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced cytotoxicity in HepG2 cells by regulating apoptotic and Nrf2/p62 pathways.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Zhao L,Zhou N,Zhang H,Pan F,Ai X,Wang Y,Hao S,Wang C
Mon Nov 01 00:00:00 EDT 2021
Antioxidant properties of red raspberry extract alleviate hepatic fibrosis via inducing apoptosis and transdifferentiation of activated hepatic stellate cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Wu TH,Wang PW,Lin TY,Yang PM,Li WT,Yeh CT,Pan TL
Wed Dec 01 00:00:00 EST 2021
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Oxidative medicine and cellular longevity
Ma N,Yang X,Qi C,Yu Q,Zhu C,Ren H
Wed May 19 00:00:00 EDT 2021
Proteomics analysis in the kidney of mice following oral feeding Realgar.
Journal of ethnopharmacology
Zhang S,Li C,Feng T,Cao S,Zhou H,Li L,Hu Q,Mao X,Ji S
Thu Jul 15 00:00:00 EDT 2021
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Frontiers in pharmacology
Li C,Zhang S,Li L,Hu Q,Ji S
Fri Nov 13 00:00:00 EST 2020
Role of CYP4F2 as a novel biomarker regulating malignant phenotypes of liver cancer cells via the Nrf2 signaling axis.
Oncology letters
Wan S,Pan Q,Yang G,Kuang J,Luo S
Thu Oct 01 00:00:00 EDT 2020
Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liang Y,Zheng B,Li J,Shi J,Chu L,Han X,Chu X,Zhang X,Zhang J
Sun Nov 01 00:00:00 EDT 2020
Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets.
Nutrients
Wang Y,Chen X,Huang Z,Chen D,Yu B,Yu J,Chen H,He J,Luo Y,Zheng P
Sat Dec 12 00:00:00 EST 2020
Induction of Nrf2 pathway by Dendrobium nobile Lindl. alkaloids protects against carbon tetrachloride induced acute liver injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Li S,Zhou J,Xu S,Li J,Liu J,Lu Y,Shi J,Zhou S,Wu Q
Sun Sep 01 00:00:00 EDT 2019
CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses.
Acta pharmacologica Sinica
Liu DD,Yuan X,Chu SF,Chen C,Ren Q,Luo P,Lin MY,Wang SS,Zhu TB,Ai QD,Zang YD,Zhang DM,He X,Huang ZH,Sun HS,Feng ZP,Chen NH
Mon Apr 01 00:00:00 EDT 2019
Procyanidin B2 mitigates behavioral impairment and protects myelin integrity in cuprizone-induced schizophrenia in mice.
RSC advances
Tian H,Sun W,Zhang Q,Li X,Sang Y,Li J,Niu Y,Ding H
Wed Jun 27 00:00:00 EDT 2018
