Invitrogen

PPAR gamma Recombinant Rabbit Monoclonal Antibody (ARC0155)

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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

MA5-35338

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0155

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PPAR gamma (P37231)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849239

Product Specific Information

Immunogen sequence: LSVMEDHSHS FDIKPFTTVD FSSISTPHYE DIPFTRTDPV VADYKYDLKL QEYQSAIKVE PASPPYYSEK TQLYNKPHEE PSNSLMAIEC RVCGDKASGF H

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; peroxisome proliferator activator receptor, gamma; Peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; PPARy

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Gene Aliases: Nr1c3; Pparg

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UniProt ID: (Rat) O88275

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Entrez Gene ID: (Rat) 25664

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Function(s)
RNA polymerase II regulatory region DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding transcription factor binding drug binding zinc ion binding enzyme binding protein phosphatase binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity activating transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding retinoid X receptor binding arachidonic acid binding alpha-actinin binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of cytokine production placenta development negative regulation of acute inflammatory response transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter fatty acid metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction heart development regulation of blood pressure negative regulation of cell proliferation response to cold response to light stimulus response to mechanical stimulus response to organic substance negative regulation of macrophage derived foam cell differentiation negative regulation of receptor biosynthetic process negative regulation of cholesterol storage negative regulation of sequestering of triglyceride response to organic cyclic compound long-chain fatty acid transport regulation of lipid metabolic process fatty acid oxidation monocyte differentiation negative regulation of cell growth epithelial cell differentiation response to caffeine organ regeneration response to food response to retinoic acid cellular response to insulin stimulus negative regulation of collagen biosynthetic process response to vitamin A response to lipid peroxisome proliferator activated receptor signaling pathway response to immobilization stress response to diuretic response to drug glucose homeostasis response to starvation regulation of circadian rhythm lipoprotein transport positive regulation of apoptotic process steroid hormone mediated signaling pathway response to estrogen cell fate commitment fat cell differentiation regulation of fat cell differentiation positive regulation of fat cell differentiation low-density lipoprotein particle receptor biosynthetic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation cell maturation rhythmic process negative regulation of smooth muscle cell proliferation positive regulation of oligodendrocyte differentiation white fat cell differentiation brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of telomerase activity response to low-density lipoprotein particle positive regulation of phagocytosis, engulfment negative regulation of interferon-gamma-mediated signaling pathway regulation of transcription involved in cell fate commitment cellular response to lithium ion cellular response to retinoic acid cellular response to vitamin E cellular response to prostaglandin stimulus cellular response to prostaglandin E stimulus cellular response to organic cyclic compound cellular response to hyperoxia negative regulation of peptide hormone secretion negative regulation of cellular response to insulin stimulus response to metformin negative regulation of pancreatic stellate cell proliferation
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