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Invitrogen
PPAR gamma Recombinant Rabbit Monoclonal Antibody (JF101-4)
Product Details
MA5-32533
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JF101-4
Immunogen
Synthetic peptide within Human PPAR gamma aa 107-150
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2809810
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma 2; peroxisome proliferator activated receptor gamma 4; peroxisome proliferator activator receptor, gamma; peroxisome proliferator-activated nuclear receptor gamma variant 1; Peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; PPARy
Gene Aliases: CIMT1; GLM1; NR1C3; PPAR-gamma; PPAR-gamma2; PPARG; PPARG1; PPARG2; PPARgamma; PPARgamma2
UniProt ID: (Human) P37231, (Mouse) P37238, (Rat) O88275
Entrez Gene ID: (Human) 5468, (Mouse) 19016, (Rat) 25664
core promoter sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
prostaglandin receptor activity
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein phosphatase binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
activating transcription factor binding
identical protein binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoid X receptor binding
arachidonic acid binding
alpha-actinin binding
RNA polymerase II regulatory region DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
metal ion binding
WW domain binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
placenta development
negative regulation of acute inflammatory response
transcription initiation from RNA polymerase II promoter
lipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
G-protein coupled receptor signaling pathway
heart development
response to nutrient
regulation of blood pressure
response to cold
response to mechanical stimulus
macrophage derived foam cell differentiation
negative regulation of macrophage derived foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
long-chain fatty acid transport
fatty acid oxidation
monocyte differentiation
negative regulation of cell growth
epithelial cell differentiation
response to caffeine
organ regeneration
response to retinoic acid
cellular response to insulin stimulus
negative regulation of collagen biosynthetic process
response to vitamin A
response to lipid
peroxisome proliferator activated receptor signaling pathway
response to immobilization stress
response to diuretic
glucose homeostasis
response to starvation
regulation of circadian rhythm
lipoprotein transport
steroid hormone mediated signaling pathway
response to estrogen
innate immune response
cell fate commitment
positive regulation of fat cell differentiation
low-density lipoprotein particle receptor biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
cell maturation
rhythmic process
negative regulation of smooth muscle cell proliferation
positive regulation of oligodendrocyte differentiation
white fat cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of telomerase activity
lipid homeostasis
response to low-density lipoprotein particle
positive regulation of phagocytosis, engulfment
negative regulation of interferon-gamma-mediated signaling pathway
regulation of cholesterol transporter activity
regulation of transcription involved in cell fate commitment
cellular response to retinoic acid
cellular response to vitamin E
cellular response to prostaglandin E stimulus
cellular response to hyperoxia
response to metformin
negative regulation of pancreatic stellate cell proliferation
negative regulation of cytokine production
response to dietary excess
diet induced thermogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
negative regulation of cell proliferation
response to light stimulus
regulation of gene expression
regulation of lipid metabolic process
intracellular receptor signaling pathway
response to food
positive regulation of apoptotic process
fat cell differentiation
regulation of fat cell differentiation
brown fat cell differentiation
cellular response to lithium ion
cellular response to organic cyclic compound
negative regulation of peptide hormone secretion
negative regulation of cellular response to insulin stimulus
fatty acid metabolic process
response to organic substance
response to organic cyclic compound
response to drug
cellular response to prostaglandin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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