Product References
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Cancer cell
Yan C,Zheng L,Jiang S,Yang H,Guo J,Jiang LY,Li T,Zhang H,Bai Y,Lou Y,Zhang Q,Liang T,Schamel W,Wang H,Yang W,Wang G,Zhu ZJ,Song BL,Xu C
Mon Jul 10 00:00:00 EDT 2023
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
Journal of cardiovascular translational research
Zou X,Liao Y,Liu Z,Xu X,Sun W,Qin H,Wang H,Liu J,Jing T
Wed Feb 01 00:00:00 EST 2023
Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma.
Frontiers in oncology
Zheng K,Hou Y,Zhang Y,Wang F,Sun A,Yang D
Tue Mar 07 00:00:00 EST 2023
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
eLife
Coates HW,Capell-Hattam IM,Olzomer EM,Du X,Farrell R,Yang H,Byrne FL,Brown AJ
Thu Jan 19 00:00:00 EST 2023
Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.
Redox biology
Kong Y,Wu M,Wan X,Sun M,Zhang Y,Wu Z,Li C,Liang X,Gao L,Ma C,Yue X
Sat Jul 01 00:00:00 EDT 2023
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data.
Cancer cell international
Zhou Z,Tang J,Lu Y,Jia J,Luo T,Su K,Dai X,Zhang H,Liu O
Sat Feb 25 00:00:00 EST 2023
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6.
Journal of lipid research
Qian L,Scott NA,Capell-Hattam IM,Draper EA,Fenton NM,Luu W,Sharpe LJ,Brown AJ
Mon May 01 00:00:00 EDT 2023
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.
Cancer discovery
Ye Z,Ai X,Yang K,Yang Z,Fei F,Liao X,Qiu Z,Gimple RC,Yuan H,Huang H,Gong Y,Xiao C,Yue J,Huang L,Saulnier O,Wang W,Zhang P,Dai L,Wang X,Wang X,Ahn YH,You C,Xu J,Wan X,Taylor MD,Zhao L,Rich JN,Zhou S
Mon Apr 03 00:00:00 EDT 2023
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Biological & pharmaceutical bulletin
Zhou H,Xu L,Shi Y,Gu S,Wu N,Liu F,Huang Y,Qian Z,Xue W,Wang X,Chen F
Thu Jan 05 00:00:00 EST 2023
SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro.
Molecular biology reports
Zhao F,Huang Y,Zhang Y,Li X,Chen K,Long Y,Li F,Ma X
Fri Jul 01 00:00:00 EDT 2022
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
International journal of biological sciences
Li J,Yang T,Wang Q,Li Y,Wu H,Zhang M,Qi H,Zhang H,Li J
Tue Jul 12 00:00:00 EDT 2022
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
International journal of biological sciences
Li J,Yang T,Wang Q,Li Y,Wu H,Zhang M,Qi H,Zhang H,Li J
Tue Jul 12 00:00:00 EDT 2022
Downregulated ferroptosis-related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma.
CNS neuroscience & therapeutics
Yao L,Li J,Zhang X,Zhou L,Hu K
Thu Dec 01 00:00:00 EST 2022
Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression.
Molecular therapy : the journal of the American Society of Gene Therapy
Hu LP,Huang W,Wang X,Xu C,Qin WT,Li D,Tian G,Li Q,Zhou Y,Chen S,Nie HZ,Hao Y,Song J,Zhang XL,Sundquist J,Sundquist K,Li J,Jiang SH,Zhang ZG,Ji J
Wed Oct 05 00:00:00 EDT 2022
Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xu XY,Choi HS,Park SY,Kim JK,Seo KH,Kim H,Kim YJ
Sat Jan 01 00:00:00 EST 2022
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Cell reports
Wang Y,Wang Y,Ding L,Ren X,Wang B,Wang L,Zhao S,Yue X,Wu Z,Li C,Liang X,Ma C,Gao L
Tue Nov 29 00:00:00 EST 2022
Acetyl-CoA Deficiency Is Involved in the Regulation of Iron Overload on Lipid Metabolism in Apolipoprotein E Knockout Mice.
Molecules (Basel, Switzerland)
Luo G,Xiang L,Xiao L
Thu Aug 04 00:00:00 EDT 2022
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
Molecular cell
McKenna MJ,Adams BM,Chu V,Paulo JA,Shao S
Thu Nov 17 00:00:00 EST 2022
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma.
Frontiers in immunology
You W,Ke J,Chen Y,Cai Z,Huang ZP,Hu P,Wu X
Tue Jun 21 00:00:00 EDT 2022
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Nature cancer
Guo C,Wan R,He Y,Lin SH,Cao J,Qiu Y,Zhang T,Zhao Q,Niu Y,Jin Y,Huang HY,Wang X,Tan L,Thomas RK,Zhang H,Chen L,Wong KK,Hu L,Ji H
Sun May 01 00:00:00 EDT 2022
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.
Cancer research
Hong Z,Liu T,Wan L,Fa P,Kumar P,Cao Y,Prasad CB,Qiu Z,Liu J,Wang H,Li Z,Wang QE,Guo P,Guo D,Yilmaz AS,Lu L,Papandreou I,Jacob NK,Yan C,Zhang X,She QB,Ma Z,Zhang J
Fri Apr 01 00:00:00 EDT 2022
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.
Cancer research
Hong Z,Liu T,Wan L,Fa P,Kumar P,Cao Y,Prasad CB,Qiu Z,Liu J,Wang H,Li Z,Wang QE,Guo P,Guo D,Yilmaz AS,Lu L,Papandreou I,Jacob NK,Yan C,Zhang X,She QB,Ma Z,Zhang J
Fri Apr 01 00:00:00 EDT 2022
Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression.
The EMBO journal
Gouirand V,Gicquel T,Lien EC,Jaune-Pons E,Da Costa Q,Finetti P,Metay E,Duluc C,Mayers JR,Audebert S,Camoin L,Borge L,Rubis M,Leca J,Nigri J,Bertucci F,Dusetti N,Iovanna JL,Tomasini R,Bidaut G,Guillaumond F,Vander Heiden MG,Vasseur S
Mon May 02 00:00:00 EDT 2022
Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer.
Cancer research
Shangguan X,Ma Z,Yu M,Ding J,Xue W,Qi J
Fri Sep 02 00:00:00 EDT 2022
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Cancer research
Ho GY,Kyran EL,Bedo J,Wakefield MJ,Ennis DP,Mirza HB,Vandenberg CJ,Lieschke E,Farrell A,Hadla A,Lim R,Dall G,Vince JE,Chua NK,Kondrashova O,Upstill-Goddard R,Bailey UM,Dowson S,Roxburgh P,Glasspool RM,Bryson G,Biankin AV,Cooke SL,Ratnayake G,McNally O,Traficante N,DeFazio A,Weroha SJ,Bowtell DD,McNeish IA,Papenfuss AT,Scott CL,Barker HE
Fri Dec 02 00:00:00 EST 2022
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Frontiers in pharmacology
Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY
Mon Jun 26 00:00:00 EDT 2023
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Frontiers in pharmacology
Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY
Mon Jun 26 00:00:00 EDT 2023
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Frontiers in pharmacology
Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY
Mon Jun 26 00:00:00 EDT 2023
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Frontiers in pharmacology
Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY
Mon Jun 26 00:00:00 EDT 2023
Comparative analysis of transient receptor potential channel 5 opposite strand-induced gene expression patterns and protein-protein interactions in triple-negative breast cancer.
Oncology letters
Peng J,Pei S,Cui Y,Xia Y,Huang Y,Wu X,Zheng M,Weng M,Han X,Fu H,Yang L,Zhou W,Fu Z,Wang S,Xie H
Mon Aug 01 00:00:00 EDT 2022
Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.
Cancer science
Jiang H,Tang E,Chen Y,Liu H,Zhao Y,Lin M,He L
Tue Mar 01 00:00:00 EST 2022
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
Cancer management and research
Liu Y,Fang L,Liu W
Sun Apr 24 00:00:00 EDT 2022
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
Cancer management and research
Liu Y,Fang L,Liu W
Sun Apr 24 00:00:00 EDT 2022
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
The Journal of biological chemistry
Grunkemeyer TJ,Ghosh S,Patel AM,Sajja K,Windak J,Basrur V,Kim Y,Nesvizhskii AI,Kennedy RT,Marsh ENG
Thu Jul 01 00:00:00 EDT 2021
HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis.
Molecular therapy. Nucleic acids
Zhang Z,Wen H,Peng B,Weng J,Zeng F
Fri Jun 04 00:00:00 EDT 2021
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
EMBO reports
Sun H,Li L,Li W,Yang F,Zhang Z,Liu Z,Du W
Tue Oct 05 00:00:00 EDT 2021
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
EMBO reports
Sun H,Li L,Li W,Yang F,Zhang Z,Liu Z,Du W
Tue Oct 05 00:00:00 EDT 2021
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
EMBO reports
Sun H,Li L,Li W,Yang F,Zhang Z,Liu Z,Du W
Tue Oct 05 00:00:00 EDT 2021
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
EMBO reports
Sun H,Li L,Li W,Yang F,Zhang Z,Liu Z,Du W
Tue Oct 05 00:00:00 EDT 2021
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
EMBO reports
Sun H,Li L,Li W,Yang F,Zhang Z,Liu Z,Du W
Tue Oct 05 00:00:00 EDT 2021
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
EMBO reports
Sun H,Li L,Li W,Yang F,Zhang Z,Liu Z,Du W
Tue Oct 05 00:00:00 EDT 2021
A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer.
Frontiers in cell and developmental biology
Yan Y,Cai J,Huang Z,Cao X,Tang P,Wang Z,Zhang F,Xia S,Shen B
Wed Sep 08 00:00:00 EDT 2021
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
Cancer communications (London, England)
He L,Li H,Pan C,Hua Y,Peng J,Zhou Z,Zhao Y,Lin M
Sun Aug 01 00:00:00 EDT 2021
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
Cancer communications (London, England)
He L,Li H,Pan C,Hua Y,Peng J,Zhou Z,Zhao Y,Lin M
Sun Aug 01 00:00:00 EDT 2021
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Nature communications
Kalogirou C,Linxweiler J,Schmucker P,Snaebjornsson MT,Schmitz W,Wach S,Krebs M,Hartmann E,Puhr M,Müller A,Spahn M,Seitz AK,Frank T,Marouf H,Büchel G,Eckstein M,Kübler H,Eilers M,Saar M,Junker K,Röhrig F,Kneitz B,Rosenfeldt MT,Schulze A
Fri Aug 20 00:00:00 EDT 2021
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Nature communications
Kalogirou C,Linxweiler J,Schmucker P,Snaebjornsson MT,Schmitz W,Wach S,Krebs M,Hartmann E,Puhr M,Müller A,Spahn M,Seitz AK,Frank T,Marouf H,Büchel G,Eckstein M,Kübler H,Eilers M,Saar M,Junker K,Röhrig F,Kneitz B,Rosenfeldt MT,Schulze A
Fri Aug 20 00:00:00 EDT 2021
The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.
The Journal of biological chemistry
Coates HW,Capell-Hattam IM,Brown AJ
Tue Aug 31 00:00:00 EDT 2021
MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE.
Frontiers in cell and developmental biology
Yang F,Kou J,Liu Z,Li W,Du W
Mon Jun 28 00:00:00 EDT 2021
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
The Biochemical journal
Scott NA,Sharpe LJ,Capell-Hattam IM,Gullo SJ,Luu W,Brown AJ
Fri Jan 31 00:00:00 EST 2020
The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.
Cell reports
Tan JME,van der Stoel MM,van den Berg M,van Loon NM,Moeton M,Scholl E,van der Wel NN,Kovačević I,Hordijk PL,Loregger A,Huveneers S,Zelcer N
Tue Aug 04 00:00:00 EDT 2020
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Cell metabolism
Fu Y,Sun Y,Wang M,Hou Y,Huang W,Zhou D,Wang Z,Yang S,Tang W,Zhen J,Li Y,Wang X,Liu M,Zhang Y,Wang B,Liu G,Yu X,Sun J,Zhang C,Yi F
Tue Dec 01 00:00:00 EST 2020
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.
Journal of cell science
Volkmar N,Thezenas ML,Louie SM,Juszkiewicz S,Nomura DK,Hegde RS,Kessler BM,Christianson JC
Wed Jan 16 00:00:00 EST 2019
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.
Journal of cell science
Volkmar N,Thezenas ML,Louie SM,Juszkiewicz S,Nomura DK,Hegde RS,Kessler BM,Christianson JC
Wed Jan 16 00:00:00 EST 2019
FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB.
Molecular biology of the cell
Pronk MCA,Majolée J,Loregger A,van Bezu JSM,Zelcer N,Hordijk PL,Kovačević I
Fri Mar 01 00:00:00 EST 2019
FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB.
Molecular biology of the cell
Pronk MCA,Majolée J,Loregger A,van Bezu JSM,Zelcer N,Hordijk PL,Kovačević I
Fri Mar 01 00:00:00 EST 2019
Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.
Biochimica et biophysica acta. Molecular and cell biology of lipids
Coates HW,Chua NK,Brown AJ
Fri Nov 01 00:00:00 EDT 2019
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.
The Biochemical journal
Chua NK,Scott NA,Brown AJ
Fri Sep 20 00:00:00 EDT 2019
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Nature
Garcia-Bermudez J,Baudrier L,Bayraktar EC,Shen Y,La K,Guarecuco R,Yucel B,Fiore D,Tavora B,Freinkman E,Chan SH,Lewis C,Min W,Inghirami G,Sabatini DM,Birsoy K
Fri Mar 01 00:00:00 EST 2019
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
Scientific reports
Werner E,Alter A,Deng Q,Dammer EB,Wang Y,Yu DS,Duong DM,Seyfried NT,Doetsch PW
Thu Aug 29 00:00:00 EDT 2019
N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2.
The Journal of biological chemistry
Nguyen KT,Lee CS,Mun SH,Truong NT,Park SK,Hwang CS
Fri Jan 04 00:00:00 EST 2019
Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum.
Journal of biochemistry
Honsho M,Dorninger F,Abe Y,Setoyama D,Ohgi R,Uchiumi T,Kang D,Berger J,Fujiki Y
Tue Oct 01 00:00:00 EDT 2019
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Experimental cell research
Zhang C,Zhang H,Zhang M,Lin C,Wang H,Yao J,Wei Q,Lu Y,Chen Z,Xing G,Cao X
Tue Oct 15 00:00:00 EDT 2019
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
EMBO reports
Stefanovic-Barrett S,Dickson AS,Burr SP,Williamson JC,Lobb IT,van den Boomen DJ,Lehner PJ,Nathan JA
Tue May 01 00:00:00 EDT 2018
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
EMBO reports
Stefanovic-Barrett S,Dickson AS,Burr SP,Williamson JC,Lobb IT,van den Boomen DJ,Lehner PJ,Nathan JA
Tue May 01 00:00:00 EDT 2018
Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Arteriosclerosis, thrombosis, and vascular biology
Loregger A,Raaben M,Tan J,Scheij S,Moeton M,van den Berg M,Gelberg-Etel H,Stickel E,Roitelman J,Brummelkamp T,Zelcer N
Wed Nov 01 00:00:00 EDT 2017
Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Arteriosclerosis, thrombosis, and vascular biology
Loregger A,Raaben M,Tan J,Scheij S,Moeton M,van den Berg M,Gelberg-Etel H,Stickel E,Roitelman J,Brummelkamp T,Zelcer N
Wed Nov 01 00:00:00 EDT 2017
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Molecular and cellular biology
Loregger A,Cook EC,Nelson JK,Moeton M,Sharpe LJ,Engberg S,Karimova M,Lambert G,Brown AJ,Zelcer N
Fri Jan 15 00:00:00 EST 2016
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Molecular and cellular biology
Loregger A,Cook EC,Nelson JK,Moeton M,Sharpe LJ,Engberg S,Karimova M,Lambert G,Brown AJ,Zelcer N
Fri Jan 15 00:00:00 EST 2016
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.
Genome biology
Haider S,McIntyre A,van Stiphout RG,Winchester LM,Wigfield S,Harris AL,Buffa FM
Wed Jun 29 00:00:00 EDT 2016
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.
Genome biology
Haider S,McIntyre A,van Stiphout RG,Winchester LM,Wigfield S,Harris AL,Buffa FM
Wed Jun 29 00:00:00 EDT 2016
Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.
The Journal of biological chemistry
Honsho M,Abe Y,Fujiki Y
Fri Nov 27 00:00:00 EST 2015
Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.
The Journal of biological chemistry
Honsho M,Abe Y,Fujiki Y
Fri Nov 27 00:00:00 EST 2015
The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
Molecular and cellular biology
Zelcer N,Sharpe LJ,Loregger A,Kristiana I,Cook EC,Phan L,Stevenson J,Brown AJ
Tue Apr 01 00:00:00 EDT 2014
The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
Molecular and cellular biology
Zelcer N,Sharpe LJ,Loregger A,Kristiana I,Cook EC,Phan L,Stevenson J,Brown AJ
Tue Apr 01 00:00:00 EDT 2014
Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
PLoS biology
Suzuki R,Ferris HA,Chee MJ,Maratos-Flier E,Kahn CR
Thu Oct 17 00:00:00 EDT 2013
Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
PLoS biology
Suzuki R,Ferris HA,Chee MJ,Maratos-Flier E,Kahn CR
Thu Oct 17 00:00:00 EDT 2013
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.
eLife
Foresti O,Ruggiano A,Hannibal-Bach HK,Ejsing CS,Carvalho P
Tue Jul 23 00:00:00 EDT 2013
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.
eLife
Foresti O,Ruggiano A,Hannibal-Bach HK,Ejsing CS,Carvalho P
Tue Jul 23 00:00:00 EDT 2013
Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.
The Journal of biological chemistry
Kristiana I,Luu W,Stevenson J,Cartland S,Jessup W,Belani JD,Rychnovsky SD,Brown AJ
Fri Sep 28 00:00:00 EDT 2012
Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.
The Journal of biological chemistry
Kristiana I,Luu W,Stevenson J,Cartland S,Jessup W,Belani JD,Rychnovsky SD,Brown AJ
Fri Sep 28 00:00:00 EDT 2012
Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.
Cell metabolism
Gill S,Stevenson J,Kristiana I,Brown AJ
Wed Mar 02 00:00:00 EST 2011
Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.
Cell metabolism
Gill S,Stevenson J,Kristiana I,Brown AJ
Wed Mar 02 00:00:00 EST 2011
Diabetes and insulin in regulation of brain cholesterol metabolism.
Cell metabolism
Suzuki R,Lee K,Jing E,Biddinger SB,McDonald JG,Montine TJ,Craft S,Kahn CR
Wed Dec 01 00:00:00 EST 2010
Diabetes and insulin in regulation of brain cholesterol metabolism.
Cell metabolism
Suzuki R,Lee K,Jing E,Biddinger SB,McDonald JG,Montine TJ,Craft S,Kahn CR
Wed Dec 01 00:00:00 EST 2010
