Proteintech

VEGFA Monoclonal Antibody (2E2H9)

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Antibody Testing Data (11)
Published Figures (8)

VEGFA Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 19

VEGFA Antibody (66828-1-IG) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed MCF-7 cells using VEGFA antibody (Product # 66828-1-IG, Clone: 2E2H9 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

VEGFA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

VEGFA Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

66828-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 66 publications 66 publications

Immunohistochemistry (IHC)

View 13 publications 13 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:400

View 6 publications 6 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2E2H9

Immunogen

VEGFA Fusion Protein Ag13500 (26-321 aa encoded by BC065522)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize all VEGFA isoforms.

Immunogen sequence: AAASRGQGP EPAPGGGVEG VGARGVALKL FVQLLGCSRF GGAVVRAGEA EPSGAARSAS SGREEPQPEE GEEEEEKEEE RGPQWRLGAR KPGSWTGEAA VCADSAPAAR APQALARASG RGGRVARRGA EESGPPHSPS RRGSASRAGP GRASETMNFL LSWVHWSLAL LLYLHHAKWS QAAPMAEGGG QNHHEVVKFM DVYQRSYCHP IETLVDIFQE YPDEIEYIFK PSCVPLMRCG GCCNDEGLEC VPTEESNITM QIMRIKPHQG QHIGEMSFLQ HNKCECRPKK DRARQEKCDK PRR (26-321 aa encoded by BC065522)

Target Information

VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma.

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Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma.

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Proliferation inhibition and apoptosis promotion by dual silencing of VEGF and Survivin in human osteosarcoma.

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Fri Nov 22 00:00:00 EST 2019

Bioinformatics

Protein Aliases: L-VEGF; MGC70609; RP1-261G23.1; VAS; Vascular endothelial growth factor A, long form; vascular endothelial growth factor A121; vascular endothelial growth factor A165; Vascular permeability factor; Vasculotropin; VEGF1; VEGFMGC70609; VPF; VPF ant

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Gene Aliases: MVCD1; VEGF; VEGFA; VPF

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UniProt ID: (Human) H3BLW7

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Entrez Gene ID: (Human) 7422

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Function(s)

fibronectin binding cytokine activity platelet-derived growth factor receptor binding vascular endothelial growth factor receptor binding protein binding growth factor activity heparin binding chemoattractant activity identical protein binding protein homodimerization activity vascular endothelial growth factor receptor 1 binding vascular endothelial growth factor receptor 2 binding protein heterodimerization activity receptor agonist activity extracellular matrix binding growth factor

Process(es)

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VEGFA Monoclonal Antibody (2E2H9)

VEGFA Antibody (66828-1-IG) in ICC/IF

Product Details

66828-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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