Product References
PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats.
Inflammopharmacology
Farid HA,Sayed RH,El-Shamarka ME,Abdel-Salam OME,El Sayed NS
MA5-15739 was used in Western Blotting to reveal that roflumilast exerted neuroprotective effects in rotenone-induced neurotoxicity in rats.
Mon Apr 01 00:00:00 EDT 2024
Methyl carbamates of phosphatidylethanolamines and phosphatidylserines reveal bacterial contamination in mitochondrial lipid extracts of mouse embryonic fibroblasts.
Scientific reports
Castellaneta A,Porcelli V,Losito I,Barile S,Maresca A,Del Dotto V,Guadalupi LS,Calvano CD,Carelli V,Palmieri L,Cataldi TRI
MA5-15739 was used in Western Blotting to investigate the presence and origin of methyl carbamates of phospholipids in mitochondrial extracts from mouse embryonic fibroblasts, differentiating between two possible routes of synthesis (chemical transformation involving phosgene and methanol, or an enzymatic methoxycarbonylation reaction due to bacterial contamination).
Sat Aug 26 00:00:00 EDT 2023
The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.
Frontiers in cell and developmental biology
Metzler VM,de Brot S,Haigh DB,Woodcock CL,Lothion-Roy J,Harris AE,Nilsson EM,Ntekim A,Persson JL,Robinson BD,Khani F,Laursen KB,Gudas LJ,Toss MS,Madhusudan S,Rakha E,Heery DM,Rutland CS,Mongan NP,Jeyapalan JN
MA5-15739 was used in Western Blotting to elucidate the individual and cooperative functions of KDM1A and KDM5B in prostate cancer.
Tue May 09 00:00:00 EDT 2023
Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process.
Frontiers in neuroscience
Kasakura N,Murata Y,Shindo A,Kitaoka S,Furuyashiki T,Suzuki K,Segi-Nishida E
MA5-15739 was used in Western Blotting to demonstrate that high NT-3 levels in the hippocampus regulate the activation of mature DG neurons and suppress the early phase of neurogenic processes, suggesting a possible role of NT-3 in the regulation of adult hippocampal function under stress conditions.
Tue Aug 15 00:00:00 EDT 2023
HIV-1 release requires Nef-induced caspase activation.
PloS one
Segura J,Ireland J,Zou Z,Roth G,Buchwald J,Shen TJ,Fischer E,Moir S,Chun TW,Sun PD
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L.
Thu Feb 16 00:00:00 EST 2023
Specific Forms of Graphene Quantum Dots Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells.
International journal of molecular sciences
Ku TH,Shen WT,Hsieh CT,Chen GS,Shia WC
MA5-15739 was used in Western Blotting to indicate that these GQDs induce apoptosis and G2/M cell cycle arrest in specific breast cancer subtypes and could potentially be used for treating breast cancers.
Fri Feb 17 00:00:00 EST 2023
Hyperglycaemia-induced impairment of the autorhythmicity and gap junction activity of mouse embryonic stem cell-derived cardiomyocyte-like cells.
Histochemistry and cell biology
Menzele A,Aboalgasm H,Ballo R,Gwanyanya A
MA5-15739 was used in Western Blotting to investigate the effect of hyperglycaemia on the pulsatile activity of stem cell-derived cardiomyocytes.
Sat Apr 01 00:00:00 EDT 2023
Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke.
EBioMedicine
Hong X,Jian Y,Ding S,Zhou J,Zheng X,Zhang H,Zhou B,Zhuang C,Wan J,Tong X
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that deficits of Kir4.1 channels in NG2 glia leads to the myelin loss of axons in a transient ischemic mouse model and that luteolin treatment promotes remyelination of axons.
Sun Jan 01 00:00:00 EST 2023
CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease.
Cells
Brustovetsky T,Khanna R,Brustovetsky N
MA5-15739 was used in Western Blotting to suggest that CRMP2, in a phosphorylation-dependent manner, participates in the regulation of mitochondrial morphology and motility, and modulates neuronal survival in AD.
Sat Apr 29 00:00:00 EDT 2023
Lovastatin, an Up-Regulator of Low-Density Lipoprotein Receptor, Enhances Follicular Development in Mouse Ovaries.
International journal of molecular sciences
Kim YJ,Cho YI,Jang J,Koo YD,Park SW,Lee JH
MA5-15739 was used in Western Blotting to investigate whether upregulation of low-density lipoprotein receptor expression using lovastatin enhances ovarian activity in mice.
Fri Apr 14 00:00:00 EDT 2023
Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function.
iScience
Bjornson KJ,Vanderplow AM,Yang Y,Anderson DR,Kermath BA,Cahill ME
MA5-15739 was used in Western Blotting to investigate how the pattern of Rap1 trafficking to synapses likely underlies its effects on the stability of select dendritic spine subtypes.
Fri Sep 15 00:00:00 EDT 2023
iPSC-derived neural precursor cells engineering GBA1 recovers acid β-glucosidase deficiency and diminishes α-synuclein and neuropathology.
Molecular therapy. Methods & clinical development
Peng Y,Liou B,Lin Y,Mayhew CN,Fleming SM,Sun Y
MA5-15739 was used in Western Blotting to support the therapeutic benefit of intravenous delivery of iPSC-derived NPCs overexpressing GCase in mitigating nGD and parkinsons disease phenotypes and establish the feasibility of combined cell and gene therapy for GBA1-associated parkinsons disease.
Thu Jun 08 00:00:00 EDT 2023
Nanotubes from bacteriophage tail sheath proteins: internalisation by cancer cells and macrophages.
Nanoscale advances
Gabrielaitis D,Zitkute V,Saveikyte L,Labutyte G,Skapas M,Meskys R,Casaite V,Sasnauskiene A,Neniskyte U
MA5-15739 was used in Western Blotting to demonstrate that gp053 nanotubes retained the cargo's enzymatic activity post-assembly and had the capacity to enter cancer cells.
Tue Jul 11 00:00:00 EDT 2023
Plp1 in the enteric nervous system is preferentially expressed during early postnatal development in mouse as DM20, whose expression appears reliant on an intronic enhancer.
Frontiers in cellular neuroscience
Patyal P,Fil D,Wight PA
MA5-15739 was used in Western Blotting to investigate Plp1 expression at the mRNA and protein levels in the intestine of mice at different ages (postnatal days 2, 9, 21, and 88).
Tue Jun 13 00:00:00 EDT 2023
A single chlamydial protein reshapes the plasma membrane and serves as recruiting platform for central endocytic effector proteins.
Communications biology
Spona D,Hanisch PT,Hegemann JH,Mölleken K
MA5-15739 was used in Inhibition Assays to show that upon adhesion to the host cell, the human pathogenic bacterium Chlamydia pneumoniae secretes the scaffolding effector protein CPn0677, which binds to the inner leaflet of the invaginating host's PM, induces inwardly directed, negative membrane curvature, and forms a recruiting platform for the membrane-deforming BAR-domain containing proteins Pacsin and SNX9.
Sat May 13 00:00:00 EDT 2023
Hsa_circ_0070440 promotes lung adenocarcinoma progression by SLC7A11-mediated-ferroptosis.
Histology and histopathology
Zhao Y,Cui Q,Shen J,Shen W,Weng Y
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that circ_0070440 contributed to malignant progression and suppressed ferroptosis of lung adenocarcinoma (LUAD) by sponging miR-485-5p and upregulating SLC7A11 expression.
Fri Dec 01 00:00:00 EST 2023
Ligustroflavone exerts neuroprotective activity through suppression of NLRP1 inflammasome in ischaemic stroke mice.
Experimental and therapeutic medicine
Bi F,Bai Y,Zhang Y,Liu W
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that LIG played an important role in anti-inflammatory and neuroprotective activity in MCAO models of ischaemic stroke.
Sun Jan 01 00:00:00 EST 2023
ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.
JCI insight
Kumar S,Fan X,Rasouly HM,Sharma R,Salant DJ,Lu W
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify a key role of ZEB2 in maintaining the cell fate of FOXD1+ stromal progenitors during kidney development, whereas loss of ZEB2 leads to differentiation of FOXD1+ stromal progenitors into myofibroblasts and kidney fibrosis.
Tue Jan 10 00:00:00 EST 2023
TEQUILA-seq: a versatile and low-cost method for targeted long-read RNA sequencing.
Nature communications
Wang F,Xu Y,Wang R,Zhang B,Smith N,Notaro A,Gaerlan S,Kutschera E,Kadash-Edmondson KE,Xing Y,Lin L
MA5-15739 was used in Western Blotting to identify transcript isoforms enriched in specific subtypes and discover novel transcript isoforms in extensively studied cancer genes such as TP53.
Tue Aug 08 00:00:00 EDT 2023
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.
Communications biology
Verma N,Velmurugan GV,Winford E,Coburn H,Kotiya D,Leibold N,Radulescu L,Despa S,Chen KC,Van Eldik LJ,Nelson PT,Wilcock DM,Jicha GA,Stowe AM,Goldstein LB,Powel DK,Walton JH,Navedo MF,Nystoriak MA,Murray AJ,Biessels GJ,Troakes C,Zetterberg H,Hardy J,Lashley T,Despa F
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show in human tissues and AD-model rats that bloodborne islet amyloid polypeptide (amylin) secreted from the pancreas perturbs cerebral Aβ clearance.
Tue Jan 03 00:00:00 EST 2023
Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors.
Biological & pharmaceutical bulletin
Matsuura S,Nishimoto Y,Endo A,Shiraki H,Suzuki K,Segi-Nishida E
MA5-15739 was used in Western Blotting to clarify temporal changes in the neuroinflammatory responses in the hippocampus and the response of dentate gyrus (DG) neurons using peripheral lipopolysaccharide (LPS)-challenged mice.
Tue Sep 05 00:00:00 EDT 2023
Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium.
International journal of molecular sciences
Song YS,Zaitoun IS,Wang S,Darjatmoko SR,Sorenson CM,Sheibani N
MA5-15739 was used in Western Blotting to demonstrate retinal endothelial cells (ECs) prepared from Cyp1b1-deficient (Cyp1b1-/-) mice exhibits increased estrogen receptor-α (ERα) activity and expresses higher levels of BMP6.
Thu Jan 26 00:00:00 EST 2023
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin α5.
Bone research
Zhao D,Hua R,Riquelme MA,Cheng H,Guda T,Xu H,Gu S,Jiang JX
MA5-15739 was used in Western Blotting to show an indispensable role of integrin α5 in osteocytes in the anabolic action of mechanical loading on skeletal tissue through activation of hemichannels and PGE2-evoked gene expression.
Mon Jul 18 00:00:00 EDT 2022
A comparison of DNA repair pathways to achieve a site-specific gene modification of the Bruton's tyrosine kinase gene.
Molecular therapy. Nucleic acids
Gray DH,Santos J,Keir AG,Villegas I,Maddock S,Trope EC,Long JD,Kuo CY
MA5-15739 was used in Western Blot to compare three methods of targeted insertion — homology-directed repair (HDR), homology-independent targeted integration (HITI), and precise integration into target chromosome (PITCh) — to achieve a permanent gene-therapy-based cure for X-linked agammaglobulinemia.
Tue Mar 08 00:00:00 EST 2022
Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Zhang H,Puviindran V,Nadesan P,Ding X,Shen L,Tang YJ,Tsushima H,Yahara Y,Ban GI,Zhang GF,Karner CM,Alman BA
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that glutaminase-mediated glutamine metabolism played distinct roles in enchondromas and chondrosarcomas with IDH1 or IDH2 mutations.
Sun May 01 00:00:00 EDT 2022
Differential effects of 5-fluorouracil and oxaliplatin on autophagy in chemoresistant colorectal cancer cells.
Journal of cellular biochemistry
Zitkute V,Kukcinaviciute E,Jonusiene V,Starkuviene V,Sasnauskiene A
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that in the context of autophagy, 5-FU and OxaPt have different effects on HCT116 and SW620 cell lines and their chemoresistant sublines.
Wed Jun 01 00:00:00 EDT 2022
Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Nature
Owji AP,Yu K,Kittredge A,Wang J,Zhang Y,Yang T
MA5-15739 was used in Western Blotting to uncover a directional permeability of BEST2 to glutamate that heavily favours glutamate exit, identify glutamine synthetase (GS) as a binding partner of BEST2 in the ciliary body of the eye, and solve the structure of the BEST2-GS complex.
Tue Nov 01 00:00:00 EDT 2022
Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway.
International journal of molecular sciences
Diniz A,Alves MG,Candeias E,Duarte AI,Moreira PI,Silva BM,Oliveira PF,Rato L
MA5-15739 was used in Western Blotting to find a significant decrease in the activities of SOD, CAT, and GPx, consistent with the lower antioxidant capacity and higher protein nitration and lipid peroxidation detected in the epididymis of the T2DM rats.
Wed Aug 10 00:00:00 EDT 2022
DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis.
BMC biology
Kim Y,Kim DY,Zhang H,Bae CR,Seong D,Kim Y,Song J,Kim YM,Kwon YG
MA5-15739 was used in Western Blot to study the role of DIX domain containing 1 (DIXDC1) in vasculature, facilitating the crosstalk between VEGF/VEGFR2 and Wnt/ β-catenin signaling pathways.
Thu Feb 10 00:00:00 EST 2022
Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics.
Cancers
Taiarol L,Bigogno C,Sesana S,Kravicz M,Viale F,Pozzi E,Monza L,Carozzi VA,Meregalli C,Valtorta S,Moresco RM,Koch M,Barbugian F,Russo L,Dondio G,Steinkühler C,Re F
MA5-15739 was used in Western Blotting to provide the proof of concept for a delivery system that can improve the in vivo half-life and increase the brain delivery of Givinostat, a pan-HDAC inhibitor.
Thu Jun 16 00:00:00 EDT 2022
Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells.
Redox biology
Kumar R,Soni H,Afolabi JM,Kanthakumar P,Mankuzhy PD,Iwhiwhu SA,Adebiyi A
MA5-15739 was used in Western Blotting to demonstrate that H2O2 triggered ECE1-dependent ET1-3 production in neonatal pig proximal tubule (PT) epithelial cells.
Thu Sep 01 00:00:00 EDT 2022
Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface.
BMC ophthalmology
Yang M,Lennikov A,Chang K,Ashok A,Lee C,Cho KS,Utheim TP,Dartt DA,Chen DF
MA5-15739 was used in Western Blotting to conclude that TcES, but not TpES, induces corneal epithelial damage in mice by disrupting mucin homeostasis, thus TpES may represent a safer and more effective ES approach for treating retinal neurodegeneration clinically.
Thu Dec 15 00:00:00 EST 2022
The Autism Spectrum Disorder-Associated Bacterial Metabolite p-Cresol Derails the Neuroimmune Response of Microglial Cells Partially via Reduction of ADAM17 and ADAM10.
International journal of molecular sciences
Zheng Y,Prince NZ,Peralta Marzal LN,Ahmed S,Garssen J,Perez Pardo P,Kraneveld AD
MA5-15739 was used in Western Blotting to demonstrate a partial role of ADAM10 and ADAM17 in the derailed innate immune response of microglial cells associated with pCS-induced ASD pathogenesis.
Tue Sep 20 00:00:00 EDT 2022
An Orally Bioavailable and Highly Efficacious Inhibitor of CDK9/FLT3 for the Treatment of Acute Myeloid Leukemia.
Cancers
Anshabo AT,Bantie L,Diab S,Lenjisa J,Kebede A,Long Y,Heinemann G,Karanjia J,Noll B,Basnet SKC,Li M,Milne R,Albrecht H,Wang S
MA5-15739 was used in Western Blot to demonstrate the potential of CDDD11-8 towards the future development of a novel AML treatment.
Tue Feb 22 00:00:00 EST 2022
Milking It for All It's Worth: The Effects of Environmental Enrichment on Maternal Nurturance, Lactation Quality, and Offspring Social Behavior.
eNeuro
DeRosa H,Caradonna SG,Tran H,Marrocco J,Kentner AC
MA5-15739 was used in Western Blotting to highlight potential deficiencies in the use of "gold standard" laboratory housing in the attempt to design translationally relevant animal models in biomedical research.
Mon Aug 29 00:00:00 EDT 2022
Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80.
Nature cancer
Shahbandi A,Chiu FY,Ungerleider NA,Kvadas R,Mheidly Z,Sun MJS,Tian D,Waizman DA,Anderson AY,Machado HL,Pursell ZF,Rao SG,Jackson JG
MA5-15739 was used in Western Blotting to reveal the challenge of eliminating residual disease populated by senescent cells expressing redundant immune inhibitory pathways and highlight the need for rational immune targeting strategies.
Thu Dec 01 00:00:00 EST 2022
Atorvastatin attenuates pulmonary fibrosis in mice and human lung fibroblasts, by the regulation of myofibroblast differentiation and apoptosis.
Journal of biochemical and molecular toxicology
Yildirim M,Kayalar O,Atahan E,Oztay F
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the effect of atorvastatin (ATR) in fibrotic mouse lung and human lung fibroblasts (MRC5s).
Fri Jul 01 00:00:00 EDT 2022
Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma.
International journal of molecular sciences
Park JW,Choi J,Lee J,Park JM,Kim SM,Min JH,Seo DY,Goo SH,Kim JH,Kwon OK,Lee K,Ahn KS,Oh SR,Lee JW
MA5-15739 was used in Western Blotting to reveal that the increases in eosinophils/Th2 cytokines/MCP-1 in the bronchoalveolar lavage fluid and IgE in the serum of OVA-induced mice with allergic asthma were effectively inhibited by Methyl p-coumarate administration.
Mon Nov 28 00:00:00 EST 2022
Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival.
Frontiers in cell and developmental biology
Vargas G,Cortés O,Arias-Muñoz E,Hernández S,Cerda-Troncoso C,Hernández L,González AE,Tatham MH,Bustamante HA,Retamal C,Cancino J,Varas-Godoy M,Hay RT,Rojas-Fernández A,Cavieres VA,Burgos PV
MA5-15739 was used in Western Blotting to explored whether HERPUD1 stability could work as a negative regulator of autophagy.
Tue Mar 22 00:00:00 EDT 2022
IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation.
Cellular signalling
Mercier V,Boucher G,Devost D,Bourque K,Alikashani A,Beauchamp C,Bitton A,Foisy S,Goyette P,Charron G,Hébert TE,Rioux JD
MA5-15739 was used in Western Blotting to define the signalling and biological pathways downstream of GPR65 activation and evaluate the impact of GPR65*231Leu on these.
Sun May 01 00:00:00 EDT 2022
Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding.
The Journal of biological chemistry
Timmermans S,Verhoog NJD,Van Looveren K,Dewaele S,Hochepied T,Eggermont M,Gilbert B,Boerema-de Munck A,Vanderhaeghen T,Vanden Berghe J,Garcia Gonzalez N,Vandewalle J,Bloch Y,Provost M,Savvides SN,De Bosscher K,Declercq W,Rottier RJ,Louw A,Libert C
MA5-15739 was used in Western Blotting to conclude that even a mutation as subtle as I634A, at a position not directly involved in ligand interactions sensu stricto, can still influence ligand binding and have a lethal outcome.
Tue Feb 01 00:00:00 EST 2022
Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
Cell
Puno MR,Lima CD
MA5-15739 was used in Western Blotting to determine cryogenic electron microscopy structures of human nuclear exosome targeting (NEXT) complexes bound to RNA that reveal mechanistic insights to substrate recognition and early steps that precede RNA handover to the exosome.
Thu Jun 09 00:00:00 EDT 2022
Mebendazole Increases Anticancer Activity of Radiotherapy in Radiotherapy-Resistant Triple-Negative Breast Cancer Cells by Enhancing Natural Killer Cell-Mediated Cytotoxicity.
International journal of molecular sciences
Choi HS,Ko YS,Jin H,Kang KM,Ha IB,Jeong H,Lee JH,Jeong BK,Kim HJ
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that MBZ + RT have an enhanced anticancer effect in TNBC which acquires radiation resistance through blocking cell cycle progression, initiating DNA double-strand breaks, and promoting NK cell-mediated cytotoxicity.
Wed Dec 07 00:00:00 EST 2022
Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor.
Nature chemical biology
Cao X,Khitun A,Harold CM,Bryant CJ,Zheng SJ,Baserga SJ,Slavoff SA
MA5-15739 was used in Western Blotting to identify nascent alt-proteins in human cells.
Wed Jun 01 00:00:00 EDT 2022
Cancer Chemopreventive Potential and Chemical Profiling of Euphorbia abyssinica Endowed with Docking Studies.
ACS omega
Ahmed SR,Hamed AR,Ali MI,Sedeek MS,Abelyan N,Al-Sanea MM
MA5-15739 was used in Western Blot to chemically profiling the fruit and aerial part extracts of Euphorbia abyssinica.
Tue Feb 01 00:00:00 EST 2022
Naringin attenuates fructose-induced NAFLD progression in rats through reducing endogenous triglyceride synthesis and activating the Nrf2/HO-1 pathway.
Frontiers in pharmacology
Pengnet S,Sumarithum P,Phongnu N,Prommaouan S,Kantip N,Phoungpetchara I,Malakul W
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that oral administration of naringin protects against fructose-induced hepatic steatosis by decreasing DNL and TG synthesis and that naringin could prevent NAFLD progression via targeting the Nrf2/HO-1 and the NF-κB/TNF-α pathways.
Tue Jan 03 00:00:00 EST 2023
Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-κB signaling pathway.
Molecular medicine (Cambridge, Mass.)
Yu Z,Su G,Zhang L,Liu G,Zhou Y,Fang S,Zhang Q,Wang T,Huang C,Huang Z,Li L
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that ICT plays roles in inhibiting the inflammatory response and achieving neuroprotection by regulating GPER-ERK-NF-κB signaling and then inhibiting microglial activation and M1 polarization while promoting M2 polarization, which provides a new therapeutic for against cerebral ischemic stroke.
Sat Nov 26 00:00:00 EST 2022
Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines.
Translational vision science & technology
Gallo RA,Qureshi F,Strong TA,Lang SH,Pino KA,Dvoriantchikova G,Pelaez D
MA5-15739 was used in Western Blotting to establish Müller glia (MG) cell lines from the regeneration-competent frog and the regeneration-deficient mouse.
Fri Apr 01 00:00:00 EDT 2022
Derivation and Characterization of Murine and Amphibian Müller Glia Cell Lines.
Translational vision science & technology
Gallo RA,Qureshi F,Strong TA,Lang SH,Pino KA,Dvoriantchikova G,Pelaez D
MA5-15739 was used in Western Blotting to establish Müller glia (MG) cell lines from the regeneration-competent frog and the regeneration-deficient mouse.
Fri Apr 01 00:00:00 EDT 2022
Reprogramming of glucocorticoid receptor function by hypoxia.
EMBO reports
Vanderhaeghen T,Timmermans S,Watts D,Paakinaho V,Eggermont M,Vandewalle J,Wallaeys C,Van Wyngene L,Van Looveren K,Nuyttens L,Dewaele S,Vanden Berghe J,Lemeire K,De Backer J,Dirkx L,Vanden Berghe W,Caljon G,Ghesquière B,De Bosscher K,Wielockx B,Palvimo JJ,Beyaert R,Libert C
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to investigate the impact of hypoxia on the hepatic response of glucocorticoid receptor (GR) to dexamethasone (DEX) in mice via RNA-sequencing.
Wed Jan 05 00:00:00 EST 2022
Adiponectin triggers breast cancer cell death via fatty acid metabolic reprogramming.
Journal of experimental & clinical cancer research : CR
Pham DV,Park PH
MA5-15739 was used in Immunocytochemistry to elucidate the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provides evidence for the connection between its metabolic actions and suppression of breast cancer.
Wed Jan 05 00:00:00 EST 2022
Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis.
Journal of neuroinflammation
Chen D,Jia G,Zhang Y,Mao H,Zhao L,Li W,Chen Y,Ni Y
MA5-15739 was used in Western Blot to demonstrate a novel protective role of Sox2 in mature and terminally differentiated cochlear hair cells by inhibiting inflammation.
Mon Feb 28 00:00:00 EST 2022
Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) Is Upregulated in Breast Epithelial-Mesenchymal Transition and Responds to Oxidative Stress.
Molecular & cellular proteomics : MCP
Wang Q,Karvelsson ST,Kotronoulas A,Gudjonsson T,Halldorsson S,Rolfsson O
MA5-15739 was used in Western Blotting to demonstrate that GFPT2 controls growth and invasion in the D492 EMT model, is a marker for oxidative stress, and associated with poor prognosis in claudin-low breast cancer.
Tue Feb 01 00:00:00 EST 2022
Structures and gating mechanisms of human bestrophin anion channels.
Nature communications
Owji AP,Wang J,Kittredge A,Clark Z,Zhang Y,Hendrickson WA,Yang T
MA5-15739 was used in Western Blotting to report cryo-EM structures of wild-type human Best1 and Best2 in various states at up to 1.8 Å resolution.
Mon Jul 04 00:00:00 EDT 2022
P2Y2R-Mediated PAK1 Activation Is Involved in ESM-1 Overexpression in RT-R-MDA-MB-231 through FoxO1 Regulation.
Cancers
Jin H,Kim HJ
MA5-15739 was used in Western Blotting to identify the mechanism by which ESM-1 is overexpressed in RT-R-MDA-MB-231 cells. RT-R-MDA-MB-231 cells were treated with various ESM-1 transcription factor inhibitors, and only the FoxO1 inhibitor downregulated ESM-1 expression.
Fri Aug 26 00:00:00 EDT 2022
Scaffold Protein Lnx1 Stabilizes EphB Receptor Kinases for Synaptogenesis.
Frontiers in molecular neuroscience
Li N,Chen S,Xu NJ,Sun S,Chen JJ,Liu XD
MA5-15739 was used in Western Blotting to reveal a molecular mechanism whereby the Lnx1-EphB complex controls postsynaptic structure for synapse maturation during the adolescent period.
Sat Jul 16 00:00:00 EDT 2022
Calcitriol Inhibits Proliferation and Potentially Induces Apoptosis in B16-F10 Cells.
Medical science monitor basic research
Sutedja EK,Amarassaphira D,Goenawan H,Susanti Pratiwi Y,Sylviana N,Setiabudiawan B,Suwarsa O,Tina Dewi Judistiani R,Supratman U,Lesmana R
MA5-15739 was used in Western Blotting to show that B16-F10 cells are capable of calcitriol uptake, with a peak uptake time at 60 min after administration.
Thu May 05 00:00:00 EDT 2022
Tyrosine phosphorylation of S1PR1 leads to chaperone BiP-mediated import to the endoplasmic reticulum.
The Journal of cell biology
Anwar M,Amin MR,Balaji Ragunathrao VA,Matsche J,Karginov A,Minshall RD,Mo GCH,Komarova Y,Mehta D
MA5-15739 was used in Western Blotting to identify Y143-phosphorylated S1PR1 as a potential target for prevention of endothelial barrier breakdown under inflammatory conditions.
Mon Nov 01 00:00:00 EDT 2021
Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
Journal of medicinal chemistry
Lee KH,Yen WC,Lin WH,Wang PC,Lai YL,Su YC,Chang CY,Wu CS,Huang YC,Yang CM,Chou LH,Yeh TK,Chen CT,Shih C,Hsieh HP
MA5-15739 was used in Western Blot to show that oral administration of 12 mesylate delayed the MC38 murine colon tumor growth and reversed the immunosuppressive tumor microenvironment with the increased M1/M2 ratio.
Thu Oct 14 00:00:00 EDT 2021
Attenuation of inward rectifier potassium current contributes to the α1-adrenergic receptor-induced proarrhythmicity in the caval vein myocardium.
Acta physiologica (Oxford, England)
Ivanova AD,Filatova TS,Abramochkin DV,Atkinson A,Dobrzynski H,Kokaeva ZG,Merzlyak EM,Pustovit KB,Kuzmin VS
MA5-15739 was used in Western Blotting to investigate the electrophysiological effects of α1-adrenoreceptor stimulation in the rat superior vena cava myocardium, which is one of the sources of proarrhythmic activity.
Thu Apr 01 00:00:00 EDT 2021
A comparative analysis of SARS-CoV-2 antivirals characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19.
Journal of virology
de Vries M,Mohamed AS,Prescott RA,Valero-Jimenez AM,Desvignes L,O'Connor R,Steppan C,Devlin JC,Ivanova E,Herrera A,Schinlever A,Loose P,Ruggles K,Koralov SB,Anderson AS,Binder J,Dittmann M
MA5-15739 was used in Western Blot to provide in vitro evidence for the potential of PF-00835231 as an effective SARS-CoV-2 antiviral and addresses concerns that emerged based on prior studies in non-human in vitro models.
Wed Mar 10 00:00:00 EST 2021
Common tumor-suppressive signaling of thyroid hormone receptor beta in breast and thyroid cancer cells.
Molecular carcinogenesis
Bolf EL,Gillis NE,Davidson CD,Cozzens LM,Kogut S,Tomczak JA,Frietze S,Carr FE
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that TRβ dampens epithelial to mesenchymal transition pathway and alters several lipid metabolism and chromatin remodeling processes.
Wed Dec 01 00:00:00 EST 2021
Developmental maturation of the colonic uptake process of the microbiota-generated thiamin pyrophosphate.
American journal of physiology. Gastrointestinal and liver physiology
Sabui S,Romero JM,Said HM
MA5-15739 was used in Western Blot to demonstrate, for the first time, to our knowledge, that colonic TPP uptake process and cTPPT expression are developmentally upregulated and that this upregulation is likely driven via transcriptional mechanism.
Sat May 01 00:00:00 EDT 2021
NF-κB activation in retinal microglia is involved in the inflammatory and neovascularization signaling in laser-induced choroidal neovascularization in mice.
Experimental cell research
Hikage F,Lennikov A,Mukwaya A,Lachota M,Ida Y,Utheim TP,Chen DF,Huang H,Ohguro H
MA5-15739 was used in Western Blotting to indicate that NF-κB activation in microglia and it's migration capacity is involved in the development of laser CNV in mice. Its suppression by NF-κB inhibition might be a promising therapeutic strategy for wet AMD.
Tue Jun 01 00:00:00 EDT 2021
α- Linolenic acid modulates phagocytosis and endosomal pathways of extracellular Tau in microglia.
Cell adhesion & migration
Desale SE,Chinnathambi S
MA5-15739 was used in Western Blotting to suggest that microglia could be influenced to reduce extracellular Tau seed with dietary fatty acids.
Wed Dec 01 00:00:00 EST 2021
Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer.
Cancer medicine
Rashid M,Ali R,Almuzzaini B,Song H,AlHallaj A,Abdulkarim AA,Mohamed Baz O,Al Zahrani H,Mustafa Sabeena M,Alharbi W,Hussein M,Boudjelal M
MA5-15739 was used in Western Blotting to report the discovery of a mutation in the CSF2RB gene of a breast cancer patient and the cell line KAIMRC1.
Mon Nov 01 00:00:00 EDT 2021
The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice.
The Journal of nutrition
Helman SL,Wilkins SJ,McKeating DR,Perkins AV,Whibley PE,Cuffe JSM,Simmons DG,Fuqua BK,Vulpe CD,Wallace DF,O'Callaghan JL,Pelzer ES,Anderson GJ,Frazer DM
MA5-15739 was used in Western Blotting to indicate that Zp is not essential for the efficient transfer of iron to the fetus in mice and is localized predominantly in the maternal decidua.
Sat Sep 04 00:00:00 EDT 2021
A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CLpro inhibitor PF-00835231 as a potential new treatment for COVID-19.
bioRxiv : the preprint server for biology
de Vries M,Mohamed AS,Prescott RA,Valero-Jimenez AM,Desvignes L,O'Connor R,Steppan C,Devlin JC,Ivanova E,Herrera A,Schinlever A,Loose P,Ruggles K,Koralov SB,Anderson AS,Binder J,Dittmann M
MA5-15739 was used in Western Blotting to provide in vitro evidence for the potential of PF-00835231 as an effective antiviral for SARS-CoV-2, addresses concerns from non-human in vitro models, and supports further studies with this compound.
Fri Feb 19 00:00:00 EST 2021
Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2.
Cells
Ali R,Al Zahrani H,Barhoumi T,Alhallaj A,Mashhour A,Alshammari MA,Alshawakir YA,Baz O,Alanazi AH,Khan AL,Al Nikhli H,Al Balwi MA,Al Riyees L,Boudjelal M
MA5-15739 was used in Western Blot to report the establishment of a naturally immortalized highly tumorigenic and triple-negative breast cancer cell line, KAIMRC2.
Mon May 24 00:00:00 EDT 2021
α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia.
Molecular biomedicine
Desale SE,Chinnathambi S
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that dietary supplement of ALA could play a neuroprotective role and slow down the AD pathology.
Tue Feb 09 00:00:00 EST 2021
α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia.
Molecular biomedicine
Desale SE,Chinnathambi S
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that dietary supplement of ALA could play a neuroprotective role and slow down the AD pathology.
Tue Feb 09 00:00:00 EST 2021
Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs).
Cancers
Koch K,Hartmann R,Suwala AK,Rios DH,Kamp MA,Sabel M,Steiger HJ,Willbold D,Sharma A,Kahlert UD,Maciaczyk J
MA5-15739 was used in Western Blot to study the metabolic dependencies of glioblastoma stem-like cells with high-resolution proton nuclear magnetic resonance spectroscopy.
Mon Nov 29 00:00:00 EST 2021
Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social memory.
Molecular psychiatry
Liu XD,Ai PH,Zhu XN,Pan YB,Halford MM,Henkemeyer M,Feng DF,Xu TL,Sun S,Xu NJ
MA5-15739 was used in Western Blotting to reveal crucial roles of postsynaptic NMDAR multiprotein complex that regulates the formation of initial social memory during the adolescent period.
Sun Aug 01 00:00:00 EDT 2021
The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity.
Scientific reports
Carruthers NJ,Strieder-Barboza C,Caruso JA,Flesher CG,Baker NA,Kerk SA,Ky A,Ehlers AP,Varban OA,Lyssiotis CA,Lumeng CN,Stemmer PM,O'Rourke RW
MA5-15739 was used in Western Blotting to identify genes and proteins regulated by type 2 diabetes to elucidate aberrant cellular metabolic and signalling mediators.
Mon Aug 30 00:00:00 EDT 2021
Stem cell transplantation rescued a primary open-angle glaucoma mouse model.
eLife
Xiong S,Kumar A,Tian S,Taher EE,Yang E,Kinchington PR,Xia X,Du Y
MA5-15739 was used in Western Blotting to show trabecular meshwork stem cells could act as a potential therapy for curing glaucoma.
Thu Jan 28 00:00:00 EST 2021
Nutmeg extract potentially alters characteristics of white adipose tissue in rats.
Veterinary medicine and science
Lesmana R,Siannoto M,Nugraha GI,Goenawan H,Feinisa AK,Pratiwi YS,Veronica F,Tarawan VM,Susianti S,Supratman U
MA5-15739 was used in Western Blot to explore the effect of nutmeg seed extract (NuSE) as a potential inductor of WAT browning.
Mon Mar 01 00:00:00 EST 2021
Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition.
Cancers
Dang TT,Morales JC
MA5-15739 was used in Western Blot to show that loss of CENP-I (Centromere Protein I) leads to increased endogenous 53BP1 foci and R-loop formation, while reducing cellular survival after ionizing radiation and Niraparib, a PARP1 small molecule inhibitor, exposures.
Sat Jun 26 00:00:00 EDT 2021
Skullcapflavone II Suppresses TNF-α/IFN-γ-Induced TARC, MDC, and CTSS Production in HaCaT Cells.
International journal of molecular sciences
Lee H,Lee DH,Oh JH,Chung JH
MA5-15739 was used in Western Blotting to indicate that SFII inhibits TNF-α/IFN-γ-induced TARC, MDC, and CTSS expression by regulating STAT1, NF-κB, and p38 MAPK signaling pathways.
Wed Jun 16 00:00:00 EDT 2021
Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation.
Molecules (Basel, Switzerland)
Yeom J,Ma S,Kim JK,Lim YH
MA5-15739 was used in Western Blotting to investigate the therapeutic effect of OXY in rats with dextran sulfate sodium (DSS)-induced acute colitis.
Fri Apr 30 00:00:00 EDT 2021
Thyroid Hormone Receptor Beta Inhibits PI3K-Akt-mTOR Signaling Axis in Anaplastic Thyroid Cancer via Genomic Mechanisms.
Journal of the Endocrine Society
Davidson CD,Bolf EL,Gillis NE,Cozzens LM,Tomczak JA,Carr FE
MA5-15739 was used in Western Blot to show that thyroid hormone receptor β suppresses phosphoinositide 3 kinase signaling in anaplastic thyroid cancer cell lines through unreported genomic mechanisms.
Sun Aug 01 00:00:00 EDT 2021
An engineered microfluidic blood-brain barrier model to evaluate the anti-metastatic activity of β-boswellic acid.
Biotechnology journal
Vakilian S,Alam K,Al-Kindi J,Jamshidi-Adegani F,Rehman NU,Tavakoli R,Al-Riyami K,Hasan A,Zadjali F,Csuk R,Al-Harrasi A,Al-Hashmi S
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to screen the effect of β-boswellic acid (β-BA) on the metastasis of MDA-MB-231 cells through the BBB in static and dynamic conditions using the Geltrex-based Transwell and microfluidic BBB models.
Fri Oct 01 00:00:00 EDT 2021
The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors.
International journal of molecular sciences
Timmerman DM,Eleveld TF,Gillis AJM,Friedrichs CC,Hillenius S,Remmers TL,Sriram S,Looijenga LHJ
MA5-15739 was used in Western Blotting to suggest that TP53 mutations contribute to the cisplatin-resistant phenotype of mediastinal GCTs and, therefore, are a potential candidate for targeted treatment.
Fri Oct 29 00:00:00 EDT 2021
The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis.
Antioxidants (Basel, Switzerland)
Mazur-Bialy AI,Pocheć E
MA5-15739 was used in Western Blotting to evaluate the kinetics of antioxidant properties of the adipomyokine irisin administered shortly before or after macrophage activation to assess its effect on the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/HMGB1 pathway.
Mon Jan 11 00:00:00 EST 2021
New Born Calf Serum Can Induce Spheroid Formation in Breast Cancer KAIMRC1 Cell Line.
Frontiers in molecular biosciences
Ali R,Huwaizi S,Alhallaj A,Al Subait A,Barhoumi T,Al Zahrani H,Al Anazi A,Latif Khan A,Boudjelal M
MA5-15739 was used in Immunocytochemistry to develop a novel and easy method to produce spheroids from the newly isolated KAIMRC1 cell line in vitro.
Tue Jan 11 00:00:00 EST 2022
Disruption of pulmonary resolution mediators contribute to exacerbated silver nanoparticle-induced acute inflammation in a metabolic syndrome mouse model.
Toxicology and applied pharmacology
Alqahtani S,Xia L,Jannasch A,Ferreira C,Franco J,Shannahan JH
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate AgNP exposure disrupts inflammatory resolution, specifically 14-HDHA and 17-HDHA derived SPMs, in MetS contributing to exacerbated acute inflammatory responses.
Mon Nov 15 00:00:00 EST 2021
Combined Targeting of PARG and Wee1 Causes Decreased Cell Survival and DNA Damage in an S-Phase-Dependent Manner.
Molecular cancer research : MCR
Agostini LC,Jain A,Shupp A,Nevler A,McCarthy G,Bussard KM,Yeo CJ,Brody JR
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate the efficacy and mechanism of action of targeting both PARG and Wee1 in PDAC and colorectal carcinoma cells.
Mon Feb 01 00:00:00 EST 2021
Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response.
Life science alliance
Silveira MA,Tav C,Bérube-Simard FA,Cuppens T,Leclercq M,Fournier É,Côté MC,Droit A,Bilodeau S
MA5-15739 was used in Western Blotting to show that high levels of the stress response master regulator, the heat shock factor 1 (HSF1), are associated with antiestrogen resistance in breast cancer cells.
Sat May 01 00:00:00 EDT 2021
Sirt1 coordinates with ERα to regulate autophagy and adiposity.
Cell death discovery
Tao Z,Shi L,Parke J,Zheng L,Gu W,Dong XC,Liu D,Wang Z,Olumi AF,Cheng Z
MA5-15739 was used in Western Blotting to show that the energy sensor Sirt1 mediates sex difference in adiposity by regulating autophagy and adipogenesis in partnership with estrogen receptor α (ERα).
Mon Mar 15 00:00:00 EDT 2021
Key Role of Microglial Matrix Metalloproteinases in Choroidal Neovascularization.
Frontiers in cellular neuroscience
Kim J,Kim JH,Do JY,Lee JY,Yanai R,Lee IK,Suk K,Park DH
MA5-15739 was used in Western Blotting to study a newly identified potential role for early microglial MMP-9 expression in CNV, and furthermore that modulating microglial MMP expression is a novel putative therapeutic for CNV.
Tue Mar 16 00:00:00 EDT 2021
7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy.
PloS one
Zaitoun IS,Song YS,Suscha A,El Ragaby M,Sorenson CM,Sheibani N
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to assess the utility of 7,8-dihydroxyflavone (DHF) in protecting the mouse retinal vasculature during oxygen-induced ischemic retinopathy.
Fri Jan 07 00:00:00 EST 2022
Stroke subtype-dependent synapse elimination by reactive gliosis in mice.
Nature communications
Shi X,Luo L,Wang J,Shen H,Li Y,Mamtilahun M,Liu C,Shi R,Lee JH,Tian H,Zhang Z,Wang Y,Chung WS,Tang Y,Yang GY
MA5-15739 was used in Western Blot to suggest that reactive microgliosis and astrogliosis play individual roles in mediating synapse engulfment in pathologically distinct murine stroke models and preventing this process could rescue synapse loss.
Fri Nov 26 00:00:00 EST 2021
Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease.
Cells
Brustovetsky T,Khanna R,Brustovetsky N
MA5-15739 was used in Western Blot to suggest that CRMP2 may regulate mitochondrial dynamics in a phosphorylation-dependent manner and modulate neuronal survival in HD.
Mon Nov 15 00:00:00 EST 2021
Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet.
Molecules (Basel, Switzerland)
Lin TA,Ke BJ,Cheng SC,Lee CL
MA5-15739 was used in Western Blot to investigate the effect of water and ethanol extraction products in red quinoa bran on the prevention of liquid alcoholic diet-induced acute liver injury in mice.
Thu Nov 18 00:00:00 EST 2021
Full-length isoform transcriptome of the developing human brain provides further insights into autism.
Cell reports
Chau KK,Zhang P,Urresti J,Amar M,Pramod AB,Chen J,Thomas A,Corominas R,Lin GN,Iakoucheva LM
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine the relationships between splicing isoform expression in the brain and de novo loss-of-function mutations from individuals with NDDs.
Tue Aug 31 00:00:00 EDT 2021
Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1.
Science bulletin
Chen YT,Hu Y,Yang QY,Liu XD,Son JS,de Avila JM,Zhu MJ,Du M
MA5-15739 was used in Western Blotting to investigate the impacts of prenatal hyper glucocorticoids on postnatal brown adipose tissue thermogenesis and underlying regulations.
Mon Mar 15 00:00:00 EDT 2021
Structural and functional characterization of the bestrophin-2 anion channel.
Nature structural & molecular biology
Owji AP,Zhao Q,Ji C,Kittredge A,Hopiavuori A,Fu Z,Ward N,Clarke OB,Shen Y,Zhang Y,Hendrickson WA,Yang T
MA5-15739 was used in Western Blotting to report cryo-EM structures of bovine bestrophin-2 (bBest2) bound and unbound by Ca2+ at 2.4- and 2.2-Å resolution, respectively.
Wed Apr 01 00:00:00 EDT 2020
BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer.
Cell death and differentiation
Shahbandi A,Rao SG,Anderson AY,Frey WD,Olayiwola JO,Ungerleider NA,Jackson JG
MA5-15739 was used in Western Blotting to look into cancer cells that have survived chemotherapy by entering senescence can be eliminated using BH3 mimetic drugs that target BCL-XL or BCL-XL/MCL1.
Sun Nov 01 00:00:00 EDT 2020
LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer.
Molecular therapy. Nucleic acids
Meng X,Sun W,Yu J,Zhou Y,Gu Y,Han J,Zhou L,Jiang X,Wang C
MA5-15739 was used in Western Blotting to uncover a mechanism for the LINC00460-miR-149-5p/miR-150-5p-mutant p53 feedback loop in oxaliplatin resistance of CRC, and they provide potential therapeutic targets for tumor chemoresistance.
Fri Dec 04 00:00:00 EST 2020
Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer's disease mice.
Translational neurodegeneration
Ai PH,Chen S,Liu XD,Zhu XN,Pan YB,Feng DF,Chen S,Xu NJ,Sun S
MA5-15739 was used in Western Blotting to show Alzheimer's disease mice display improved emotional function and memory as a result of paroxetine administration.
Tue May 12 00:00:00 EDT 2020
A chalcone derivative, 1m-6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation-induced endothelial dysfunction.
British journal of pharmacology
Chen LW,Tsai MC,Chern CY,Tsao TP,Lin FY,Chen SJ,Tsui PF,Liu YW,Lu HJ,Wu WL,Lin WS,Tsai CS,Lin CS
MA5-15739 was used in Western Blot to develop an effective chalcone derivative with antiatherogenic potential.
Tue Dec 01 00:00:00 EST 2020
CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma.
British journal of cancer
Mo XT,Leung TH,Tang HW,Siu MK,Wan PK,Chan KK,Cheung AN,Ngan HY
MA5-15739 was used in Western Blot to demonstrate the carcinogenic properties of CD109 in cervical cancer enabled via CD109/EGFR/STAT3 signalling.
Tue Sep 01 00:00:00 EDT 2020
Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p.
Frontiers in cell and developmental biology
Jankowska KI,McGill J,Pezeshkpoor B,Oldenburg J,Sauna ZE,Atreya CD
MA5-15739 was used in Western Blotting to established orthogonal in vivo RNA-affinity purification approach was utilized to directly identify a group of F8-interacting miRNAs and we tested them for F8/FVIII suppression.
Mon Sep 28 00:00:00 EDT 2020
The sialyltransferase ST6GAL1 protects against radiation-induced gastrointestinal damage.
Glycobiology
Punch PR,Irons EE,Manhardt CT,Marathe H,Lau JTY
MA5-15739 was used in Western Blotting to investigate the contribution of ST6GAL1 to susceptibility to total body irradiation in vivo.
Mon Jul 20 00:00:00 EDT 2020
Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology.
American journal of physiology. Endocrinology and metabolism
Martins AD,Jarak I,Morais T,Carvalho RA,Oliveira PF,Monteiro MP,Alves MG
MA5-15739 was used in Western Blotting to study whether caloric restriction (CR) changes testicular metabolic profile and ultimately sperm quality.
Wed Jan 01 00:00:00 EST 2020
Noncanonical function of long myosin light chain kinase in increasing ER-PM junctions and augmentation of SOCE.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Srivastava N,Tauseef M,Amin R,Joshi B,Joshi JC,Kini V,Klomp J,Li W,Knezevic N,Barbera N,Siddiqui S,Obukhov A,Karginov A,Levitan I,Komarova Y,Mehta D
MA5-15739 was used in Western Blotting to show that thapsigargin and thrombin-induced SOCE was markedly reduced in Mylk-L-/- endothelial cells (EC) or MYLK-L-depleted human EC.
Tue Sep 01 00:00:00 EDT 2020
Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Griffiths KK,Wang A,Wang L,Tracey M,Kleiner G,Quinzii CM,Sun L,Yang G,Perez-Zoghbi JF,Licznerski P,Yang M,Jonas EA,Levy RJ
MA5-15739 was used in Western Blot to demonstrate that FMRP deficiency results in inefficient oxidative phosphorylation during the neurodevelopment and suggest that dysfunctional mitochondria may contribute to the FXS phenotype.
Mon Jun 01 00:00:00 EDT 2020
Porf-2 Inhibits Tumor Cell Migration Through the MMP-2/9 Signaling Pathway in Neuroblastoma and Glioma.
Frontiers in oncology
Li XY,Huang GH,Liu QK,Yang XT,Wang K,Luo WZ,Liang TS,Yuan SP,Zhen YW,Yan DM
MA5-15739 was used in Western Blotting to demonstrate that Porf-2 is capable of suppressing tumor cell migration via its GAP domain and the downregulation of MMP-2/9.
Mon Sep 28 00:00:00 EDT 2020
Uncovering a Shared Epitope-Activated Protein Citrullination Pathway.
Journal of immunology (Baltimore, Md. : 1950)
van Drongelen V,Ali WH,Holoshitz J
MA5-15739 was used in Western Blotting to demonstrate that stimulation of murine macrophages with LPS or DTT facilitated cell surface translocation of calreticulin, which in turn enabled increased SE-activated calcium signaling and activation of peptidylarginine deiminase with the resultant increased cellular abundance of citrullinated proteins.
Sat Aug 01 00:00:00 EDT 2020
Expression level of NEAT1 differentiates benign and malignant thyroid nodules by regulating NEAT1/miR‑9/PTEN and NEAT1/miR‑124/PDCD6 signalling.
International journal of molecular medicine
Zhao L,Zhou N,Zhao P
MA5-15739 was used in Western Blotting to investigate differences in expression of long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1), microRNA (miR)-9, miR-124, PTEN and programmed cell death protein 6 (PDCD6), in benign and malignant thyroid nodules.
Sun Nov 01 00:00:00 EDT 2020
Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network.
Journal of Cancer
Zhu D,Shao M,Yang J,Fang M,Liu S,Lou D,Gao R,Liu Y,Li A,Lv Y,Mo Z,Fan Q
MA5-15739 was used in Western Blot to explore the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC).
Mon Sep 28 00:00:00 EDT 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
MA5-15739 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 EST 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
MA5-15739 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 EST 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
MA5-15739 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 EST 2020
Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.
Experimental cell research
Lennikov A,Mukwaya A,Fan L,Saddala MS,De Falco S,Huang H
MA5-15739 was used in Western Blot, Immunohistochemistry to investigate the role of placental growth factor/vascular endothelial growth factor (PlGF-VEGF) heterodimers involved in the blood-retinal barrier breakdown and the associated mechanism.
Tue Dec 15 00:00:00 EST 2020
Androgen up-regulation of Twist1 gene expression is mediated by ETV1.
PeerJ
Khatiwada P,Kannan A,Malla M,Dreier M,Shemshedini L
MA5-15739 was used in Western Blotting to demonstrate that Twist1 as an indirect target of the androgen receptor and androgen regulation through Ets Variant 1 (ETV1).
Mon Sep 28 00:00:00 EDT 2020
The preventive effect of Apocynum venetum polyphenols on D-galactose-induced oxidative stress in mice.
Experimental and therapeutic medicine
Guo H,Kuang Z,Zhang J,Zhao X,Pu P,Yan J
MA5-15739 was used in Western Blot to study the preventive effect of AVP against D-galactose-induced oxidative stress in a mouse model.
Wed Jan 01 00:00:00 EST 2020
Hypoxia and transforming growth factor β1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts.
Physiological reports
Senavirathna LK,Huang C,Pushparaj S,Xu D,Liu L
MA5-15739 was used in Western Blotting to show mRNAs and lncRNAs in human pulmonary fibroblasts are regulated by synergistic interaction between hypoxia and TGFβ1.
Wed Jan 01 00:00:00 EST 2020
EphB2 mediates social isolation-induced memory forgetting.
Translational psychiatry
Wu XR,Zhang Y,Liu XD,Han WB,Xu NJ,Sun S
MA5-15739 was used in Western Blotting to indicate that social isolation gives rise to memory forgetting by disrupting EphB2-mediated synaptic plasticity, which may provide a potential target for preventing memory loss caused by social isolation or loneliness.
Mon Nov 09 00:00:00 EST 2020
A slow, efficient and safe nanoplatform of tailored ZnS QD-mycophenolic acid conjugates for in vitro drug delivery against dengue virus 2 genome replication.
Nanoscale advances
Dungdung R,Bayal M,Valliyott L,Unniyampurath U,Nair SS,Pilankatta R
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that the Selectivity Index 50 (SI50) of the ZnS QD-MPA conjugate was two orders higher than that of free MPA with lower cytotoxicity.
Tue Dec 15 00:00:00 EST 2020
Adaptation to Endoplasmic Reticulum Stress Enhances Resistance of Oral Cancer Cells to Cisplatin by Up-Regulating Polymerase η and Increasing DNA Repair Efficiency.
International journal of molecular sciences
Chen CY,Kawasumi M,Lan TY,Poon CL,Lin YS,Wu PJ,Chen YC,Chen BH,Wu CH,Lo JF,Weng RR,Sun YC,Hung KF
MA5-15739 was used in Western Blotting to uncover that adaptation to ER stress enhances DNA repair and damage tolerance, with which stressed cells gain resistance to chemotherapeutics.
Thu Dec 31 00:00:00 EST 2020
A novel protective role of sacubitril/valsartan in cyclophosphamide induced lung injury in rats: impact of miRNA-150-3p on NF-κB/MAPK signaling trajectories.
Scientific reports
Abdel-Latif GA,Elwahab AHA,Hasan RA,ElMongy NF,Ramzy MM,Louka ML,Schaalan MF
MA5-15739 was used in Western Blotting to conclude that sacubitril/valsartan effectively abrogated the CP induced lung inflammation and fibrosis, providing a potential promising protection that could be linked to their ability to inhibit miR-150-3p via inhibition of NF-κB and MAPK signaling pathways.
Mon Aug 03 00:00:00 EDT 2020
Loss-of-function of EBP50 is a new cause of hereditary peripheral neuropathy: EBP50 functions in peripheral nerve system.
Glia
Song GJ,Gupta DP,Rahman MH,Park HT,Al Ghouleh I,Bisello A,Lee MG,Park JY,Park HH,Jun JH,Chung KW,Choi BO,Suk K
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show for the first time that loss of function due to EBP50 gene deficiency or mutation can cause peripheral neuropathy.
Tue Sep 01 00:00:00 EDT 2020
Maf1 regulates dendritic morphogenesis and influences learning and memory.
Cell death & disease
Chen K,Zhu L,Guo L,Pan YB,Feng DF
MA5-15739 was used in Western Blotting to show for the first time that Maf1 inhibits dendritic morphogenesis and the growth of dendritic spines through AKT-mTOR signaling by increasing PTEN expression.
Thu Jul 30 00:00:00 EDT 2020
Oxyresveratrol Induces Autophagy via the ER Stress Signaling Pathway, and Oxyresveratrol-Induced Autophagy Stimulates MUC2 Synthesis in Human Goblet Cells.
Antioxidants (Basel, Switzerland)
Yeom J,Ma S,Lim YH
MA5-15739 was used in Western Blotting to investigate the effect of OXY in autophagy and it's effect on MUC2 expression in human intestinal goblet cells.
Thu Mar 05 00:00:00 EST 2020
Adiponectin receptor fragmentation in mouse models of type 1 and type 2 diabetes.
Archives of autoimmune diseases
Frabutt D,Stull N,Pineros AR,Tersey SA,Scheuner D,Mastracci TL,Pugia MJ
MA5-15739 was used in Immunohistochemistry to investigate physiological variations in the concentrations of CTF in non-obese diabetic (NOD/ShiLtJ) mice and C57BL/6 mice with diet-induced obesity (DIO) as models of diabetes types 1 and 2, respectively.
Sat Aug 21 00:00:00 EDT 2021
Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion.
Theranostics
Zhang LY,Pan J,Mamtilahun M,Zhu Y,Wang L,Venkatesh A,Shi R,Tu X,Jin K,Wang Y,Zhang Z,Yang GY
MA5-15739 was used in Western Blotting to explore whether activated microglia aggravate white matter injury via complement C3-C3aR pathway after chronic cerebral hypoperfusion.
Fri Apr 02 00:00:00 EDT 2021
MiR-203-3p inhibits the oxidative stress, inflammatory responses and apoptosis of mice podocytes induced by high glucose through regulating Sema3A expression.
Open life sciences
Chen J,Xu Q,Zhang W,Zhen Y,Cheng F,Hua G,Lan J,Tu C
MA5-15739 was used in Western Blot to reveal that miR-203-3p alleviated the podocyte injury induced by HG via regulating Sema3A expression.
Tue Apr 06 00:00:00 EDT 2021
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis.
Nature communications
Dinh PC,Paudel D,Brochu H,Popowski KD,Gracieux MC,Cores J,Huang K,Hensley MT,Harrell E,Vandergriff AC,George AK,Barrio RT,Hu S,Allen TA,Blackburn K,Caranasos TG,Peng X,Schnabel LV,Adler KB,Lobo LJ,Goshe MB,Cheng K
MA5-15739 was used in Western Blotting to show that an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis.
Fri Feb 28 00:00:00 EST 2020
Blood-Borne ST6GAL1 Regulates Immunoglobulin Production in B Cells.
Frontiers in immunology
Irons EE,Punch PR,Lau JTY
MA5-15739 was used in Western Blotting to determine the effect of extracellular ST6GAL1 in B cell immunoglobulin production.
Thu Mar 25 00:00:00 EDT 2021
Graphene oxide nanofilm and the addition of L-glutamine can promote development of embryonic muscle cells.
Journal of nanobiotechnology
Zielińska-Górska M,Hotowy A,Wierzbicki M,Bałaban J,Sosnowska M,Jaworski S,Strojny B,Chwalibog A,Sawosz E
MA5-15739 was used in Western Blotting to study the interaction between surface properties, culture medium composition and heterogeneous cell culture.
Fri May 15 00:00:00 EDT 2020
Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells.
Cell reports
Erra Díaz F,Ochoa V,Merlotti A,Dantas E,Mazzitelli I,Gonzalez Polo V,Sabatté J,Amigorena S,Segura E,Geffner J
MA5-15739 was used in Flow Cytometry to investigate the role of pH on the differentiation of monocytes into dendritic cells.
Tue May 05 00:00:00 EDT 2020
In Vitro Evaluation of Lignin-Containing Nanocellulose.
Materials (Basel, Switzerland)
Kim D,Jeong J,Ryu JA,Choi SR,Lee JM,Bunch H
MA5-15739 was used in Western Blotting to indicate that L-MFC displays cell-type-dependent sensitivity and suggest that L-MFC could serve as a new eco-friendly material that is relatively safe for humans.
Wed Jul 29 00:00:00 EDT 2020
Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma.
Journal of neuroinflammation
Yang X,Zeng Q,Barış M,Tezel G
MA5-15739 was used in Western Blotting to determine the value of astroglial NF-κB as a potential treatment target for immunomodulation in experimental mouse glaucoma.
Fri Aug 28 00:00:00 EDT 2020
Mechanoadaptive organization of stress fiber subtypes in epithelial cells under cyclic stretches and stretch release.
Scientific reports
Roshanzadeh A,Nguyen TT,Nguyen KD,Kim DS,Lee BK,Lee DW,Kim ES
MA5-15739 was used in Western Blotting to propose a model for stretch-induced responses of the cytoplasm and nucleus in epithelial cells based on different mechanoadaptive properties of stress fibre subtypes.
Thu Oct 29 00:00:00 EDT 2020
Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS.
Nature communications
Wu X,Niculite CM,Preda MB,Rossi A,Tebaldi T,Butoi E,White MK,Tudoran OM,Petrusca DN,Jannasch AS,Bone WP,Zong X,Fang F,Burlacu A,Paulsen MT,Hancock BA,Sandusky GE,Mitra S,Fishel ML,Buechlein A,Ivan C,Oikonomopoulos S,Gorospe M,Mosley A,Radovich M,Davé UP,Ragoussis J,Nephew KP,Mari B,McIntyre A,Konig H,Ljungman M,Cousminer DL,Macchi P,Ivan M
MA5-15739 was used in Western Blot to provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem.
Mon Sep 21 00:00:00 EDT 2020
Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq.
Nature communications
Brockway S,Wang G,Jackson JM,Amici DR,Takagishi SR,Clutter MR,Bartom ET,Mendillo ML
MA5-15739 was used in Western Blotting to develop Quantitative and Multiplexed Analysis of Phenotype by Sequencing (QMAP-Seq), which leverages next-generation sequencing for pooled high-throughput chemical-genetic profiling.
Thu Nov 12 00:00:00 EST 2020
Saccharide analog, 2-deoxy-d-glucose enhances 4-1BB-mediated antitumor immunity via PD-L1 deglycosylation.
Molecular carcinogenesis
Kim B,Sun R,Oh W,Kim AMJ,Schwarz JR,Lim SO
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest a new immunotherapeutic strategy to enhance antitumor immunity by PD-L1 deglycosylation and 4-1BB stimulation in triple-negative breast cancer (TNBC).
Wed Jul 01 00:00:00 EDT 2020
Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress.
International journal of molecular sciences
Dang TT,Morales JC
MA5-15739 was used in Western Blotting to demonstrate a role for POLA2 in DSB repair and resistance to genotoxic stress.
Mon Jun 15 00:00:00 EDT 2020
Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells.
Scientific reports
Dubey T,Gorantla NV,Chandrashekara KT,Chinnathambi S
MA5-15739 was used in Immunocytochemistry-immunoflourescence to study the protective role of Rose Bengal against Tau aggregation and cytoskeleton modulations.
Thu Jul 23 00:00:00 EDT 2020
Inhibitors of BRAF dimers using an allosteric site.
Nature communications
Cotto-Rios XM,Agianian B,Gitego N,Zacharioudakis E,Giricz O,Wu Y,Zou Y,Verma A,Poulikakos PI,Gavathiotis E
MA5-15739 was used in Western Blotting to demonstrate the significant value of screening specific phenotypic assays with additional kinase inhibitors to identify alternative uses and targets.
Tue Sep 01 00:00:00 EDT 2020
The impact of regional astrocyte interferon-γ signaling during chronic autoimmunity: a novel role for the immunoproteasome.
Journal of neuroinflammation
Smith BC,Sinyuk M,Jenkins JE,Psenicka MW,Williams JL
MA5-15739 was used in Western Blotting to reveal a protective role for IFNγ in chronic neuroinflammation and identify a novel function of the iP in astrocytes during CNS autoimmunity.
Fri Jun 12 00:00:00 EDT 2020
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV.
Nature communications
Zhao Y,Ye X,Shehata M,Dunker W,Xie Z,Karijolich J
MA5-15739 was used in Western Blotting to demonstrate that NMD restricts KSHV lytic reactivation.
Fri Jul 03 00:00:00 EDT 2020
T-2 Toxin-Induced Oxidative Stress Leads to Imbalance of Mitochondrial Fission and Fusion to Activate Cellular Apoptosis in the Human Liver 7702 Cell Line.
Toxins
Yang J,Guo W,Wang J,Yang X,Zhang Z,Zhao Z
MA5-15739 was used in Western Blotting to indicate that altered mitochondrial dynamics induced by oxidative stress with T-2 toxin exposure likely contribute to mitochondrial injury and HL-7702 cell apoptosis.
Fri Jan 10 00:00:00 EST 2020
Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.
Cell
Dong MB,Wang G,Chow RD,Ye L,Zhu L,Dai X,Park JJ,Kim HR,Errami Y,Guzman CD,Zhou X,Chen KY,Renauer PA,Du Y,Shen J,Lam SZ,Zhou JJ,Lannin DR,Herbst RS,Chen S
MA5-15739 was used in Western Blot to identify genomic regulators of tumor infiltration and degranulation in CD8 T cells directly under cancer immunotherapy settings.
Thu Aug 22 00:00:00 EDT 2019
Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses.
Cancer research
Daher B,Parks SK,Durivault J,Cormerais Y,Baidarjad H,Tambutte E,Pouysségur J,Vučetić M
MA5-15739 was used in Western Blotting to show the cystine/glutamate exchanger xCT is essential for amino acid and redox homeostasis and its inhibition has potential for anticancer therapy by inducing ferroptosis.
Thu Aug 01 00:00:00 EDT 2019
Targeting the Temporal Dynamics of Hypoxia-Induced Tumor-Secreted Factors Halts Tumor Migration.
Cancer research
Singh M,Tian XJ,Donnenberg VS,Watson AM,Zhang J,Stabile LP,Watkins SC,Xing J,Sant S
MA5-15739 was used in Western Blotting to study temporal dynamics of tumor-secreted microenvironmental factors in inducing tumor migration.
Sat Jun 01 00:00:00 EDT 2019
MicroRNA-148a/b-3p regulates angiogenesis by targeting neuropilin-1 in endothelial cells.
Experimental & molecular medicine
Kim H,Ko Y,Park H,Zhang H,Jeong Y,Kim Y,Noh M,Park S,Kim YM,Kwon YG
MA5-15739 was used in Western Blotting to demonstrate that miR-148a/b-3p is a therapeutic candidate for overcoming endothelial cell dysfunction and angiogenic disorders.
Wed Nov 13 00:00:00 EST 2019
Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival.
The Journal of cell biology
Tonnessen-Murray CA,Frey WD,Rao SG,Shahbandi A,Ungerleider NA,Olayiwola JO,Murray LB,Vinson BT,Chrisey DB,Lord CJ,Jackson JG
MA5-15739 was used in Western Blotting to show that chemotherapy-induced senescent cells frequently engulf both neighboring senescent or nonsenescent tumor cells at a remarkable frequency.
Mon Nov 04 00:00:00 EST 2019
Human IFIT proteins inhibit lytic replication of KSHV: A new feed-forward loop in the innate immune system.
PLoS pathogens
Li D,Swaminathan S
MA5-15739 was used in Western Blotting to study the effects of Kaposi's sarcoma-associated herpesvirus lytic replication on IFIT expression in epithelial cells.
Fri Feb 01 00:00:00 EST 2019
Spatial Determination of Neuronal Diversification in the Olfactory Epithelium.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Coleman JH,Lin B,Louie JD,Peterson J,Lane RP,Schwob JE
MA5-15739 was used in Western Blotting to demonstrate that, via transplantation of stem and progenitor cells from dorsal OE into ventral OE, in mice of both sexes, nonautonomous spatial cues can direct the spatially circumscribed differentiation of olfactory sensory neurons.
Wed Jan 30 00:00:00 EST 2019
Cell Cycle Arrest in G2/M Phase Enhances Replication of Interferon-Sensitive Cytoplasmic RNA Viruses via Inhibition of Antiviral Gene Expression.
Journal of virology
Bressy C,Droby GN,Maldonado BD,Steuerwald N,Grdzelishvili VZ
MA5-15739 was used in Western Blot to investigate how the cell cycle affects replication of vesicular stomatitis viruses.
Fri Feb 15 00:00:00 EST 2019
SALM4 regulates angiogenic functions in endothelial cells through VEGFR2 phosphorylation at Tyr1175.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kim DY,Park JA,Kim Y,Noh M,Park S,Lie E,Kim E,Kim YM,Kwon YG
MA5-15739 was used in Western Blotting to report that synaptic adhesion-like molecule 4 regulates a specific VEGFR2 phosphorylation site.
Sun Sep 01 00:00:00 EDT 2019
4-Phenylbutyrate Ameliorates Anxiety Disorder by Inhibiting Endoplasmic Reticulum Stress after Diffuse Axonal Injury.
Journal of neurotrauma
Huang GH,Chen K,Sun YY,Zhu L,Sun ZL,Feng DF
MA5-15739 was used in Western Blotting to show that DAI can trigger ER stress and unfolded protein response (UPR) activation in both the acute and chronic periods, leading to cell death and anxiety disorder.
Sat Jun 01 00:00:00 EDT 2019
Inositol pyrophosphates and Akt/PKB: Is the pancreatic β-cell the exception to the rule?
Cellular signalling
Kim J,Darè E,Rajasekaran SS,Ryu SH,Berggren PO,Barker CJ
MA5-15739 was used in Western Blot to conclude that pharmacological strategies to knock down IP6K activity might not have the same positive output in the β-cell as in other insulin regulated tissues.
Sat Jun 01 00:00:00 EDT 2019
MAPK/ERK pathway inhibition is a promising treatment target for adrenocortical tumors.
Journal of cellular biochemistry
Pereira SS,Monteiro MP,Costa MM,Ferreira J,Alves MG,Oliveira PF,Jarak I,Pignatelli D
MA5-15739 was used in Western Blotting to evaluate the role of two mitogen activated protein kinase signalling pathways in the adrenocortical tumorigenesis.
Tue Jan 01 00:00:00 EST 2019
ANO6 promotes cell proliferation and invasion in glioma through regulating the ERK signaling pathway.
OncoTargets and therapy
Xuan ZB,Wang YJ,Xie J
MA5-15739 was used in Western Blotting to reveal that ANO6 activated ERK signalling pathway through promoting the nuclear translocation of ERK to increase the proliferation and invasion of glioblastoma cells.
Mon Apr 11 00:00:00 EDT 2022
SRPX and HMCN1 regulate cancer‑associated fibroblasts to promote the invasiveness of ovarian carcinoma.
Oncology reports
Liu CL,Pan HW,Torng PL,Fan MH,Mao TL
MA5-15739 was used in Western Blotting to study the role of cancer-associated fibroblasts in promoting ovarian cancer invasion using clinical ovarian cancer specimens.
Sun Dec 01 00:00:00 EST 2019
Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats.
Journal of applied microbiology
Ducray HAG,Globa L,Pustovyy O,Morrison E,Vodyanoy V,Sorokulova I
MA5-15739 was used in Western Blotting to evaluate efficacy of Saccharomyces cerevisiae fermentate prebiotic in protection of intestinal barrier integrity in rats during heat stress, to analyze the impact of heat stress and preventive treatment with EH on the structure of the gut microbiota.
Tue Oct 01 00:00:00 EDT 2019
Danggui buxue tang inhibited mesangial cell proliferation and extracellular matrix accumulation through GAS5/NF-κB pathway.
Bioscience reports
Zhang R,Han X,Huang T,Wang X
MA5-15739 was used in Western Blotting to explore the effect of Danggui buxue tang (DGT) on the proliferation of high glucose (HG)-induced mesangial cells and accumulation of extracellular matrix in mesangial cells.
Wed Oct 30 00:00:00 EDT 2019
Replication of HIV-1 envelope protein cytoplasmic domain variants in permissive and restrictive cells.
Virology
Staubus AO,Alfadhli A,Barklis RL,Barklis E
MA5-15739 was used in Western Blotting to study how cytoplasmic tails (CT) elements regulate HIV-1 envelope (Env) protein function.
Sun Dec 01 00:00:00 EST 2019
Fasudil may induce the differentiation of bone marrow mesenchymal stem cells into neuron‑like cells via the Wnt/β‑catenin pathway.
Molecular medicine reports
Hu Y,Li X,Huang G,Wang J,Lu W
MA5-15739 was used in Western Blotting to investigate the effect of fasudil on the differentiation of mesenchymal stem cells into neuron-like cells.
Mon Apr 01 00:00:00 EDT 2019
Glutamine synthetase in avian muscle contributes to a positive myogenic response to ammonia compared with mammalian muscle.
American journal of physiology. Regulatory, integrative and comparative physiology
Stern RA,Mozdziak PE
MA5-15739 was used in Western Blotting to identify differences between avian and mammalian myogenic response to applied ammonia and glutamine.
Mon Jul 01 00:00:00 EDT 2019
Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis.
Experimental and therapeutic medicine
Zang J,Ye J,Zhang C,Sha M,Gao J
MA5-15739 was used in Western Blot to suggest that chemokines secreted by senescent hepatocytes can upregulate activity in natural killer cells through the CXCL-10/CXCR3 axis.
Fri Nov 01 00:00:00 EDT 2019
Glucocorticoid-Induced Autophagy Protects Osteocytes Against Oxidative Stress Through Activation of MAPK/ERK Signaling.
JBMR plus
Kar R,Riquelme MA,Hua R,Jiang JX
MA5-15739 was used in Western Blotting to study the effect of glucocorticoid induced autophagy on oxidative stress in osteocytes.
Mon Apr 01 00:00:00 EDT 2019
Protective Effects of Kuding Tea (Ilex kudingcha C. J. Tseng) Polyphenols on UVB-Induced Skin Aging in SKH1 Hairless Mice.
Molecules (Basel, Switzerland)
Yi R,Zhang J,Sun P,Qian Y,Zhao X
MA5-15739 was used in Western Blotting to study the protective effects of Kuding tea polyphenols on ultraviolet B-induced skin injury of SKH1 hairless mice.
Wed Mar 13 00:00:00 EDT 2019
Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model.
PloS one
Bral M,Pawlick R,Marfil-Garza B,Dadheech N,Hefler J,Thiesen A,Shapiro AMJ
MA5-15739 was used in Western Blotting to show application of pan-caspase inhibitor F573 can decrease markers of cellular injury, decrease evidence of apoptosis, and improve cytokine profile in murine liver ischemia reperfusion injury.
Thu Apr 02 00:00:00 EDT 2020
Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression.
Frontiers in immunology
Javitt A,Barnea E,Kramer MP,Wolf-Levy H,Levin Y,Admon A,Merbl Y
MA5-15739 was used in Western Blotting to examine the effect that TNFα and IFNγ stimulation may exert on the immunopeptidome landscape of lung cancer cells.
Mon Jan 06 00:00:00 EST 2020
Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice.
The Journal of biological chemistry
Lebeau PF,Byun JH,Platko K,MacDonald ME,Poon SV,Faiyaz M,Seidah NG,Austin RC
MA5-15739 was used in Western Blotting to examine the effect of hepatic steatosis on LDLR expression and circulating LDL cholesterol levels.
Fri Jun 07 00:00:00 EDT 2019
Treatment of established TH2 cells with 4μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion.
BMC immunology
Poe C,Youngblood C,Hodge K,Kemp K
MA5-15739 was used in Western Blotting to study the mechanism of action of 4μ8c in Th2 cells.
Thu Jan 10 00:00:00 EST 2019
The c-Myc-regulated miR-17-92 cluster mediates ATRA-induced APL cell differentiation.
Asia-Pacific journal of clinical oncology
Yu X,Hu Y,Wu Y,Fang C,Lai J,Chen S,Li Y,Zeng C,Zeng Y
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify miR-17-92 as a target gene of c-Myc during ATRA-induced granulocytic differentiation.
Sun Dec 01 00:00:00 EST 2019
CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release.
eLife
Ajasin DO,Rao VR,Wu X,Ramasamy S,Pujato M,Ruiz AP,Fiser A,Bresnick AR,Kalpana GV,Prasad VR
MA5-15739 was used in Western Blotting to show that CCL2-mediated increase in virus production requires Gag late motif LYPX present in HIV-1B, but absent in HIV-1C, and ALIX protein that recruits ESCRT III complex.
Fri Jun 07 00:00:00 EDT 2019
Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells.
Science advances
Sanderson SM,Mikhael PG,Ramesh V,Dai Z,Locasale JW
MA5-15739 was used in Western Blotting to demonstrate that many factors, particularly nutrition, can overwhelm the effects of metabolic gene deletions on metabolism.
Sat Jun 01 00:00:00 EDT 2019
N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration.
eLife
Kon E,Calvo-Jiménez E,Cossard A,Na Y,Cooper JA,Jossin Y
MA5-15739 was used in Western Blotting to reveal novel functions for FGFRs in cortical projection neuron migration, suggest a physiological role for FGFR and N-Cadherin interaction in vivo and identify Reelin as an extracellular upstream regulator and Erk1/2 as downstream effectors of FGFRs during neuron migration.
Wed Oct 02 00:00:00 EDT 2019
Helicobacter pylori-activated gastric fibroblasts induce epithelial-mesenchymal transition of gastric epithelial cells in vitro in a TGF-β-dependent manner.
Helicobacter
Krzysiek-Maczka G,Wrobel T,Targosz A,Szczyrk U,Strzalka M,Ptak-Belowska A,Czyz J,Brzozowski T
MA5-15739 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to determine the phenotypic properties of gastric fibroblasts exposed to Hp (cagA+vacA+) infection and their influence on normal epithelial RGM-1 cells.
Tue Oct 01 00:00:00 EDT 2019
ASB6 Promotes the Stemness Properties and Sustains Metastatic Potential of Oral Squamous Cell Carcinoma Cells by Attenuating ER Stress.
International journal of biological sciences
Hung KF,Liao PC,Chen CK,Chiu YT,Cheng DH,Kawasumi M,Kao SY,Lo JF
MA5-15739 was used in Western Blotting to study the role of cellular and molecular role of ASB6 in the malignancy of oral squamous cell carcinoma.
Mon Mar 16 00:00:00 EDT 2020
LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea.
Biomolecules
Flores R,Jin X,Chang J,Zhang C,Cogan DG,Schaefer EJ,Kruth HS
MA5-15739 was used in Western Blotting to examine the expression of LCAT by the cell types that comprise from anterior to posterior the three layers of the cornea.
Tue Nov 26 00:00:00 EST 2019
Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Immunity
Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN
MA5-15739 was used in Western Blotting to study the role of transient receptor potential melastatin-like 7 in mediating the cytosolic Ca2+ elevations essential for lipopolysaccharide-induced macrophage activation.
Tue Jan 16 00:00:00 EST 2018
Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation.
Nucleic acids research
Li T,Wang L,Du Y,Xie S,Yang X,Lian F,Zhou Z,Qian C
MA5-15739 was used in Western Blotting to present the crystal structure of DNMT1 RFTS domain in complex with ubiquitin and highlight a unique ubiquitin binding mode for the RFTS domain.
Fri Apr 06 00:00:00 EDT 2018
Mitochondrial alternative oxidase-dependent autophagy involved in ethylene-mediated drought tolerance in Solanum lycopersicum.
Plant biotechnology journal
Zhu T,Zou L,Li Y,Yao X,Xu F,Deng X,Zhang D,Lin H
MA5-15739 was used in Western Blotting to study the response of mitochondrial alternative oxidase to drought in Solanum lycopersicum.
Sat Dec 01 00:00:00 EST 2018
Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1.
The Journal of cell biology
Liu XD,Zhu XN,Halford MM,Xu TL,Henkemeyer M,Xu NJ
MA5-15739 was used in Western blotting following immunoprecipitation to define a retrograde trans-synaptic regulation required for integration of post- and presynaptic structure that participates in building hippocampal neural circuits during the adolescence period.
Mon Nov 05 00:00:00 EST 2018
Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1.
The Journal of cell biology
Liu XD,Zhu XN,Halford MM,Xu TL,Henkemeyer M,Xu NJ
MA5-15739 was used in Western blotting following immunoprecipitation to define a retrograde trans-synaptic regulation required for integration of post- and presynaptic structure that participates in building hippocampal neural circuits during the adolescence period.
Mon Nov 05 00:00:00 EST 2018
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
PLoS pathogens
Tsai K,Courtney DG,Cullen BR
MA5-15739 was used in Western Blotting to study the role of adenosine methylation at the N6 position in the regulation of polyomavirus simian virus 40 gene expression.
Thu Feb 01 00:00:00 EST 2018
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult.
Molecular neurobiology
Cabezas R,Vega-Vela NE,González-Sanmiguel J,González J,Esquinas P,Echeverria V,Barreto GE
MA515739 was used in western blot to discuss mechanisms associated with platelet-derived growth factor, subtype BB protection against oxidative damage
Sun Apr 01 00:00:00 EDT 2018
Influenza A virus-derived siRNAs increase in the absence of NS1 yet fail to inhibit virus replication.
RNA (New York, N.Y.)
Tsai K,Courtney DG,Kennedy EM,Cullen BR
MA5-15739 was used in Western Blotting to demonstrate that these siRNAs have little if any inhibitory effect on IAV gene expression.
Sat Sep 01 00:00:00 EDT 2018
GW4064 attenuates lipopolysaccharide‑induced hepatic inflammation and apoptosis through inhibition of the Toll‑like receptor 4‑mediated p38 mitogen‑activated protein kinase signaling pathway in mice.
International journal of molecular medicine
Liu HM,Lee TY,Liao JF
MA5-15739 was used in Western Blotting to investigate the capacity of GW4064 to protect the livers of mice from lipopolysaccharide-induced inflammation and apoptosis.
Thu Mar 01 00:00:00 EST 2018
Insights into the mechanisms underlying the inactivation of HIV-1 proviruses by CRISPR/Cas.
Virology
Mefferd AL,Bogerd HP,Irwan ID,Cullen BR
MA5-15739 was used in Western Blotting to report that two sgRNAs specific for the HIV-1 transactivation response element produce opposite results.
Sun Jul 01 00:00:00 EDT 2018
Myokine irisin-induced protection against oxidative stress in vitro. Involvement of heme oxygenase-1 and antioxidazing enzymes superoxide dismutase-2 and glutathione peroxidase.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Mazur-Bialy AI,Kozlowska K,Pochec E,Bilski J,Brzozowski T
MA5-15739 was used in Western Blotting to determine the ability of irisin to interact with reactive oxygen species in RAW 264.7 murine macrophages.
Thu Feb 01 00:00:00 EST 2018
A dock derived compound against laminin receptor (37 LR) exhibits anti-cancer properties in a prostate cancer cell line model.
Oncotarget
Umbaugh CS,Diaz-Quiñones A,Neto MF,Shearer JJ,Figueiredo ML
MA5-15739 was used in Western Blotting to identify a compound with potential for future development in treating tumour growth and inhibiting angiogenesis.
Fri Jan 19 00:00:00 EST 2018
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
Nature communications
Zhao Y,Ye X,Dunker W,Song Y,Karijolich J
MA5-15739 was used in Western Blotting to study the relationship between RNA processing and innate immunity, and demonstrate that an antiviral innate immune response can be elicited by the sensing of misprocessed cellular RNAs.
Mon Nov 19 00:00:00 EST 2018
Hepatoprotective Effects of Lactobacillus on Carbon Tetrachloride-Induced Acute Liver Injury in Mice.
International journal of molecular sciences
Chen X,Zhang J,Yi R,Mu J,Zhao X,Yang Z
MA5-15739 was used in Western Blotting to investigate and compare the effects of heat-killed and live Lactobacillus on carbon tetrachloride-induced acute liver injury in mice.
Sun Jul 29 00:00:00 EDT 2018
NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
JCI insight
Barruet E,Morales BM,Cain CJ,Ton AN,Wentworth KL,Chan TV,Moody TA,Haks MC,Ottenhoff TH,Hellman J,Nakamura MC,Hsiao EC
MA5-15739 was used in Western Blotting to examine the potential link between bone morphogenetic proteins and inflammation in patients with fibrodysplasia ossificans progressiva.
Thu Nov 15 00:00:00 EST 2018
Metabolomics reveals critical adrenergic regulatory checkpoints in glycolysis and pentose-phosphate pathways in embryonic heart.
The Journal of biological chemistry
Peoples JNR,Maxmillian T,Le Q,Nadtochiy SM,Brookes PS,Porter GA,Davidson VL,Ebert SN
MA5-15739 was used in Western Blotting to study the effects of adrenergic hormones on metabolism in the embryonic heart.
Fri May 04 00:00:00 EDT 2018
Complement activation contributes to perioperative neurocognitive disorders in mice.
Journal of neuroinflammation
Xiong C,Liu J,Lin D,Zhang J,Terrando N,Wu A
MA5-15739 was used in Western Blotting to evaluate the possible role for C3/C3a receptor signalling following orthopaedic surgery.
Tue Sep 04 00:00:00 EDT 2018
Leptin Promotes Allergic Airway Inflammation through Targeting the Unfolded Protein Response Pathway.
Scientific reports
Zheng H,Wu D,Wu X,Zhang X,Zhou Q,Luo Y,Yang X,Chock CJ,Liu M,Yang XO
MA5-15739 was used in Western Blotting to study how obesity-associated elevation of leptin increases the risk of asthma.
Mon Jun 11 00:00:00 EDT 2018
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture.
Frontiers in neuroscience
Lukiw WJ,Cong L,Jaber V,Zhao Y
MA5-15739 was used in Western Blotting to characterise a neuron-specific effect of a human gastrointestinal-tract microbiome-derived neurotoxin on decreased neurofilament light abundance in both sporadic Alzheimer's disease temporal lobe neocortex in vivo and in lipopolysaccharide-stressed HNG cells in vitro.
Tue Sep 29 00:00:00 EDT 2020
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
MA5-15739 was used in Western Blot to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Cell metabolism
Liberti MV,Dai Z,Wardell SE,Baccile JA,Liu X,Gao X,Baldi R,Mehrmohamadi M,Johnson MO,Madhukar NS,Shestov AA,Chio IIC,Elemento O,Rathmell JC,Schroeder FC,McDonnell DP,Locasale JW
MA5-15739 was used in Western Blotting to develop a predictive model for selective targeting of the Warburg effect.
Tue Oct 03 00:00:00 EDT 2017
Ufm1 inhibits LPS-induced endothelial cell inflammatory responses through the NF-κB signaling pathway.
International journal of molecular medicine
Li YY,Zhang GY,He JP,Zhang DD,Kong XX,Yuan HM,Chen FL
MA5-15739 was used in Western Blotting to show that Ufm1 is upregulated in LPS-induced inflammation and Ufm1 plays an inhibitory role in inflammatory responses by targeting NF-κB nuclear translocation.
Mon May 01 00:00:00 EDT 2017
Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features.
Journal of physiology and biochemistry
Yadav S,Tiwari V,Singh M,Yadav RK,Roy S,Devi U,Gautam S,Rawat JK,Ansari MN,Saeedan AS,Prakash A,Saraf SA,Kaithwas G
MA5-15739 was used in western blot to assess the effect of alpha-linolenic acid and gamma-linolenic acid in an autism model
Mon May 01 00:00:00 EDT 2017
Oxygen Levels Regulate the Development of Human Cortical Radial Glia Cells.
Cerebral cortex (New York, N.Y. : 1991)
Ortega JA,Sirois CL,Memi F,Glidden N,Zecevic N
MA5-15739 was used in Western Blotting to analyse the effects of oxygen levels on human cortical progenitors during active neurogenesis, corresponding to the second trimester of gestation.
Sat Jul 01 00:00:00 EDT 2017
TRPV4 channels contribute to renal myogenic autoregulation in neonatal pigs.
American journal of physiology. Renal physiology
Soni H,Peixoto-Neves D,Matthews AT,Adebiyi A
MA5-15739 was used in Western Blotting to indicate that TRPV4 channels are mechanosensors in neonatal pig preglomerular vascular SMCs and contribute to renal myogenic autoregulation.
Wed Nov 01 00:00:00 EDT 2017
Hypothermia exerts early neuroprotective effects involving protein conjugation of SUMO‑2/3 in a rat model of middle cerebral artery occlusion.
Molecular medicine reports
Li G,Liu X,Su Z,Zhang D
MA5-15739 was used in Western Blotting to investigate changes in the level of small ubiquitin-related modifier protein when neurons are exposed to oxygen-glucose deprivation.
Fri Sep 01 00:00:00 EDT 2017
Regulation of autophagy inhibition and inflammatory response in glioma by Wnt signaling pathway.
Oncology letters
Wang T,Chen Z,Zhang W
MA5-15739 was used in Western Blotting to investigate the mechanism of the function of Wnt signalling pathway in regulating autophagy and the inflammatory response in glioma cells.
Fri Dec 01 00:00:00 EST 2017
Protective effect and mechanism of estrogen receptor β on myocardial infarction in mice.
Experimental and therapeutic medicine
Zhang JB,Guo CL
MA5-15739 was used in Western Blotting to explore the protective effect and mechanism of oestrogen receptor Β on myocardial infarction in mice.
Tue Aug 01 00:00:00 EDT 2017
The c-Jun N-terminal kinase prevents oxidative stress induced by UV and thermal stresses in corals and human cells.
Scientific reports
Courtial L,Picco V,Grover R,Cormerais Y,Rottier C,Labbe A,Pagès G,Ferrier-Pagès C
MA5-15739 was used in Western Blotting to suggest that an ancestral response, involving the JNK pathway, is remarkably conserved from corals to human, protecting cells from the adverse environmental effects.
Tue Apr 04 00:00:00 EDT 2017
Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus in vitro.
The Journal of biological chemistry
Zhu J,Miao Q,Tan Y,Guo H,Liu T,Wang B,Chen Z,Li C,Liu G
MA5-15739 was used in Western Blotting to construct a mutant rabbit haemorrhagic disease virus with a receptor-recognition motif in its capsid protein, enabling its culture in vitro.
Fri May 26 00:00:00 EDT 2017
Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions.
Marine drugs
Hung YP,Lee CL
MA5-15739 was used in Western Blotting to examine the anti-liver fibrosis effects and mechanisms of different Cordyceps militaris-fermented products in murine liver fibrosis.
Thu Jun 08 00:00:00 EDT 2017
p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells.
The Journal of biological chemistry
Nickless A,Cheruiyot A,Flanagan KC,Piwnica-Worms D,Stewart SA,You Z
MA5-15739 was used in Western Blotting to study the underlying mechanism gene expression reprogramming induced by persistent DNA damage.
Fri Sep 15 00:00:00 EDT 2017
Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium.
BBA clinical
Vishnyakova PA,Volodina MA,Tarasova NV,Marey MV,Kan NE,Khodzhaeva ZS,Vysokikh MY,Sukhikh GT
MA5-15739 was used in Western Blotting to suggest that crucial molecular changes in the maternal myometrium occur with the development of preeclampsia.
Fri Dec 01 00:00:00 EST 2017
Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.
PloS one
Asam K,Staniszewski A,Zhang H,Melideo SL,Mazzeo A,Voronkov M,Huber KL,Pérez E,Stock M,Stock JB,Arancio O,Nicholls RE
MA5-15739 was used in Western Blotting to investigate whether eicosanoyl-5-hydroxytryptamide protects animals from the pathological effects of exposure to elevated levels of soluble oligomeric beta-amyloid.
Mon Jan 08 00:00:00 EST 2018
Different pathogenicities of Rice stripe virus from the insect vector and from viruliferous plants.
The New phytologist
Zhao W,Yang P,Kang L,Cui F
MA5-15739 was used in western blot to investigate how persistent viruses acquire pathogenicity from insect vectors
Fri Apr 01 00:00:00 EDT 2016
NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways.
Frontiers in immunology
Yuen J,Pluthero FG,Douda DN,Riedl M,Cherry A,Ulanova M,Kahr WH,Palaniyar N,Licht C
MA5-15739 was used in western blot to compare activation of complement both on their own NETs and bacteria via non-alternative and alternative pathways by NETosing neutrophils
Thu May 05 00:00:00 EDT 2016
Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus.
Frontiers in immunology
Lin TH,Cheng CC,Su HH,Huang NC,Chen JJ,Kang HY,Chang TH
MA5-15739 was used in Western Blotting to examine the effect of lipopolysaccharide on the expression of the proallergic cytokines thymic stromal lymphopoietin and interleukin 33 in H292 cells.
Wed Nov 20 00:00:00 EST 2019
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
Oxidative medicine and cellular longevity
Zou P,Liu L,Zheng LD,Payne KK,Manjili MH,Idowu MO,Zhang J,Schmelz EM,Cheng Z
MA5-15739 was used in western blot to study mitochondrial biogenesis and mitophagy in cancer cells
Mon Mar 13 00:00:00 EDT 2017
DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties.
Oncogenesis
Little AC,Sham D,Hristova M,Danyal K,Heppner DE,Bauer RA,Sipsey LM,Habibovic A,van der Vliet A
MA5-15739 was used in western blot to elucidate the role of DUOX1 silencing in lung cancer development or progression
Mon Oct 03 00:00:00 EDT 2016
The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication.
Journal of molecular biology
Lopez AP,Kugelman JR,Garcia-Rivera J,Urias E,Salinas SA,Fernandez-Zapico ME,Llano M
MA5-15739 was used in Western Blotting to demonstrate the association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 in HIV-1 infection.
Sun Jul 17 00:00:00 EDT 2016
Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice.
Disease models & mechanisms
Gil VS,Bhagat G,Howell L,Zhang J,Kim CH,Stengel S,Vega F,Zelent A,Petrie K
MA5-15739 was used in western blot to study histone deacetylase 9 in diffuse large B-cell lymphoma
Thu Dec 01 00:00:00 EST 2016
Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis.
The international journal of biochemistry & cell biology
Meneses MJ,Bernardino RL,Sá R,Silva J,Barros A,Sousa M,Silva BM,Oliveira PF,Alves MG
MA5-15739 was used in western blot to evaluate the effects of pioglitazone on human Sertoli cells metabolism
Sat Oct 01 00:00:00 EDT 2016
FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes.
Cell cycle (Georgetown, Tex.)
Liu L,Zheng LD,Zou P,Brooke J,Smith C,Long YC,Almeida FA,Liu D,Cheng Z
MA5-15739 was used in western blot to learn suppression of autophagy and lipid droplet growth in adipocytes by FoxO1 antagonist
Tue Aug 02 00:00:00 EDT 2016
α-Chymotrypsin regulates free fatty acids and UCHL-1 to ameliorate N-methyl nitrosourea induced mammary gland carcinoma in albino wistar rats.
Inflammopharmacology
Rani A,Roy S,Singh M,Devi U,Yadav RK,Gautam S,Rawat JK,Ansari MN,Saeedan AS,Prakash A,Kaithwas G
MA5-15739 was used in western blot to determine the effect of alpha-chymotrypsin on methyl nitrosourea-induced mammary gland carcinoma using albino wistar rats
Sat Oct 01 00:00:00 EDT 2016
The Role of Sonic Hedgehog in the Specification of Human Cortical Progenitors In Vitro.
Cerebral cortex (New York, N.Y. : 1991)
Radonjić NV,Memi F,Ortega JA,Glidden N,Zhan H,Zecevic N
MA5-15739 was used in western blot to study the relation between human cortical formation and impaired sonic hedgehog signaling
Fri Jan 01 00:00:00 EST 2016
Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics.
Molecular and cellular endocrinology
Martins AD,Sá R,Monteiro MP,Barros A,Sousa M,Carvalho RA,Silva BM,Oliveira PF,Alves MG
MA5-15739 was used in western blot to examine the effect of ghrelin in human Sertoli cells metabolism
Sat Oct 15 00:00:00 EDT 2016
Stiffness of pancreatic cancer cells is associated with increased invasive potential.
Integrative biology : quantitative biosciences from nano to macro
Nguyen AV,Nyberg KD,Scott MB,Welsh AM,Nguyen AH,Wu N,Hohlbauch SV,Geisse NA,Gibb EA,Robertson AG,Donahue TR,Rowat AC
MA5-15739 was used in western blot to report that stiffer pancreatic ductal adenocarcinoma cells are more invasive than more compliant cells
Mon Dec 05 00:00:00 EST 2016
Effects of acupuncture on cortical expression of Wnt3a, β-catenin and Sox2 in a rat model of traumatic brain injury.
Acupuncture in medicine : journal of the British Medical Acupuncture Society
Zhang YM,Dai QF,Chen WH,Jiang ST,Chen SX,Zhang YJ,Tang CZ,Cheng SB
MA5-15739 was used in western blot to assess the effects of acupuncture treatment on the expression of Wnt/beta-catenin signaling pathway-related genes in rats with traumatic brain injury
Mon Feb 01 00:00:00 EST 2016
An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.
The Journal of biological chemistry
Druso JE,Endo M,Lin MC,Peng X,Antonyak MA,Meller S,Cerione RA
MA5-15739 was used in Western Blotting to demonstrate that Cdc42 plays essential roles, establishing proper epithelial cell polarity and tissue homeostasis, in mammary gland function post pregnancy.
Fri Apr 22 00:00:00 EDT 2016
ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries.
Nature communications
Bowles J,Feng CW,Miles K,Ineson J,Spiller C,Koopman P
MA5-15739 was used in western blot to identify a retinoic acid-synthesizing enzyme, ALDH1A1, that is expressed in fetal ovaries
Fri Feb 19 00:00:00 EST 2016
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood.
Nature communications
Rebo J,Mehdipour M,Gathwala R,Causey K,Liu Y,Conboy MJ,Conboy IM
MA5-15739 was used in western blot to study the benefits of heterochronic parabiosis in young and old mice
Tue Nov 22 00:00:00 EST 2016
Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma.
PloS one
Roy A,Femel J,Huijbers EJ,Spillmann D,Larsson E,Ringvall M,Olsson AK,Åbrink M
MA5-15739 was used in western blot to analyze prevention of metastasis in murine mammary carcinoma by targeting serglycin
Mon Jul 10 00:00:00 EDT 2017
A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs.
Nature biotechnology
Choi J,Lee S,Mallard W,Clement K,Tagliazucchi GM,Lim H,Choi IY,Ferrari F,Tsankov AM,Pop R,Lee G,Rinn JL,Meissner A,Park PJ,Hochedlinger K
MA5-15739 was used in western blot to study the cellular origin of human induced pluripotent stem cells and human embryonic stem cells
Sun Nov 01 00:00:00 EDT 2015
Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7.
PLoS pathogens
Pfoh R,Lacdao IK,Georges AA,Capar A,Zheng H,Frappier L,Saridakis V
MA5-15739 was used in western blot to study the binding of ICP0 to USP7.
Mon Jun 01 00:00:00 EDT 2015
Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rolyan H,Tyurina YY,Hernandez M,Amoscato AA,Sparvero LJ,Nmezi BC,Lu Y,Estécio MR,Lin K,Chen J,He RR,Gong P,Rigatti LH,Dupree J,Bayır H,Kagan VE,Casaccia P,Padiath QS
MA5-15739 was used in western blot to elucidate the mechanisms by which increased LMNB1 levels cause autosomal dominant leukodystrophy
Wed Aug 26 00:00:00 EDT 2015
Dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone in male reproductive health: Implications of differential regulation of human Sertoli cells metabolic profile.
The Journal of steroid biochemistry and molecular biology
Dias TR,Alves MG,Almeida SP,Silva J,Barros A,Sousa M,Silva BM,Silvestre SM,Oliveira PF
MA5-15739 was used in western blot to assess the effects of dehydroepiandrosterone and 7-oxo-dehydroepiandrosterone on human Sertoli cells metabolism and oxidative profile.
Sun Nov 01 00:00:00 EDT 2015
Co-culture of 3D tumor spheroids with fibroblasts as a model for epithelial-mesenchymal transition in vitro.
Experimental cell research
Kim SA,Lee EK,Kuh HJ
MA5-15739 was used in western blot to develop a 3D model for studying tumors by co-culturing HT-29 tumor spheroids with CCD-18co fibroblasts
Wed Jul 15 00:00:00 EDT 2015
Effects of Ras homolog gene family, member C gene silencing combined with rapamycin on hepatocellular carcinoma cell growth.
Molecular medicine reports
Xie SL,Zhu MG,Chen GF,Wang GY,Lv GY
MA5-15739 was used in Western Blotting to investigate the effectiveness of RNAi in silencing RhoC, to inhibit the growth of hepatocellular carcinoma cells.
Thu Oct 01 00:00:00 EDT 2015
Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.
The Journal of biological chemistry
Nieves-Cintrón M,Nystoriak MA,Prada MP,Johnson K,Fayer W,Dell'Acqua ML,Scott JD,Navedo MF
MA5-15739 was used in western blot to assess if impaired voltage-gated K(+) channel function contributes to arterial tone during diabetes
Fri Mar 20 00:00:00 EDT 2015
Novel Insertion Mutation in KCNJ5 Channel Produces Constitutive Aldosterone Release From H295R Cells.
Molecular endocrinology (Baltimore, Md.)
Hardege I,Xu S,Gordon RD,Thompson AJ,Figg N,Stowasser M,Murrell-Lagnado R,O'Shaughnessy KM
MA5-15739 was used in western blot to investigate KCNJ5 mutations in Australian primary aldosteronism samples
Thu Oct 01 00:00:00 EDT 2015
AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.
Circulation research
Nystoriak MA,Nieves-Cintrón M,Nygren PJ,Hinke SA,Nichols CB,Chen CY,Puglisi JL,Izu LT,Bers DM,Dell'acqua ML,Scott JD,Santana LF,Navedo MF
MA5-15739 was used in western blot to test if AKAP150 mediates BKCa channel suppression during hyperglycemia and diabetes mellitus
Fri Feb 14 00:00:00 EST 2014
Control of glutamine metabolism by the tumor suppressor Rb.
Oncogene
Reynolds MR,Lane AN,Robertson B,Kemp S,Liu Y,Hill BG,Dean DC,Clem BF
MA5-15739 was used in western blot to determine whether the tumor suppressor Rb is involved in glutamine metabolism
Thu Jan 30 00:00:00 EST 2014
Papillomavirus E6 PDZ interactions can be replaced by repression of p53 to promote episomal human papillomavirus genome maintenance.
Journal of virology
Brimer N,Vande Pol SB
MA5-15739 was used in western blot to study episomal HPV genome maintenance
Sat Mar 01 00:00:00 EST 2014
Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Carcinogenesis
Tanwar PS,Mohapatra G,Chiang S,Engler DA,Zhang L,Kaneko-Tarui T,Ohguchi Y,Birrer MJ,Teixeira JM
MA5-15739 was used in western blot to study the role of LKB1 and PTEN loss in ovarian surface epithelial cells in the development of the papillary serous histotype of ovarian cancer
Sat Mar 01 00:00:00 EST 2014
The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.
Channels (Austin, Tex.)
Liu J,Supnet C,Sun S,Zhang H,Good L,Popugaeva E,Bezprozvanny I
MA5-15739 was used in western blot to assess the importance of RyanR type 3 in Alzheimer disease pathology
Tue Jun 16 00:00:00 EDT 2015
Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury.
Journal of neuroinflammation
Li ZW,Li JJ,Wang L,Zhang JP,Wu JJ,Mao XQ,Shi GF,Wang Q,Wang F,Zou J
MA5-15739 was used in western blot to study the control of excessive reactive astrogliosis and improved functional recovery in a rat model of spinal cord injury treated with an EGFR tyrosine kinase inhibitor
Sat Apr 05 00:00:00 EDT 2014
Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection.
PloS one
Notari L,Riera DC,Sun R,Bohl JA,McLean LP,Madden KB,van Rooijen N,Vanuytsel T,Urban JF,Zhao A,Shea-Donohue T
MA5-15739 was used in western blot to study the enteric nematode infection-induced type 2 immune response and the the role of macrophages in the associated impairment of epithelial glucose absorption
Tue Nov 11 00:00:00 EST 2014
Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy.
PloS one
Gurel Z,Zaro BW,Pratt MR,Sheibani N
MA5-15739 was used in western blot to identify murine retinal pericyte proteins that are modified by O-GlcNAC and the potential role of p53 O-GlcNAcylation in the pathogenesis of diabetic retinopathy
Thu Dec 18 00:00:00 EST 2014
Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats.
Pathogens and disease
Lafferty MK,Fantry L,Bryant J,Jones O,Hammoud D,Weitzmann MN,Lewis GK,Garzino-Demo A,Reid W
MA5-15739 was used in western blot to investigate the mechanisms underlying dysregulated osteoclastogenesis in HIV
Sun Jun 01 00:00:00 EDT 2014
The promotion of functional recovery and nerve regeneration after spinal cord injury by lentiviral vectors encoding Lingo-1 shRNA delivered by Pluronic F-127.
Biomaterials
Wu HF,Cen JS,Zhong Q,Chen L,Wang J,Deng DY,Wan Y
MA5-15739 was used in western blot to examine the effects of Lingo-1 knockdown on recovery after spinal cord injury
Fri Feb 01 00:00:00 EST 2013
Dynamic mast cell-stromal cell interactions promote growth of pancreatic cancer.
Cancer research
Ma Y,Hwang RF,Logsdon CD,Ullrich SE
MA5-15739 was used in western blot to determine whether mast cells promote growth of pancreatic cancer
Mon Jul 01 00:00:00 EDT 2013
Amylin deposition in the brain: A second amyloid in Alzheimer disease?
Annals of neurology
Jackson K,Barisone GA,Diaz E,Jin LW,DeCarli C,Despa F
MA5-15739-1MG was used in western blot to study the formation of amylin amyloid deposits in the cerebrovascular system and the implications for Alzheimer's disease
Tue Oct 01 00:00:00 EDT 2013
Pravastatin attenuates hypertension, oxidative stress, and angiogenic imbalance in rat model of placental ischemia-induced hypertension.
Hypertension (Dallas, Tex. : 1979)
Bauer AJ,Banek CT,Needham K,Gillham H,Capoccia S,Regal JF,Gilbert JS
MA5-15739 was used in western blot to study the effects of prevastatin on placental ischemia-induced hypertension
Wed May 01 00:00:00 EDT 2013
Integration of protein abundance and structure data reveals competition in the ErbB signaling network.
Science signaling
Kiel C,Verschueren E,Yang JS,Serrano L
MA5-15739 was used in western blot to study the ERbB signaling network with a view to understanding the basis for context-specific signaling plasticity
Tue Dec 17 00:00:00 EST 2013
In vitro Intestinal Mucosal Epithelial Responses to Wild-Type Salmonella Typhi and Attenuated Typhoid Vaccines.
Frontiers in immunology
Fiorentino M,Lammers KM,Levine MM,Sztein MB,Fasano A
MA5-15739 was used in western blot to assess in vitro the effects of several S. Typhi strains and the licensed Ty21a typhoid vaccine on intestinal barrier function and immune response
Fri Feb 15 00:00:00 EST 2013
Up-regulation of vitamin B1 homeostasis genes in breast cancer.
The Journal of nutritional biochemistry
Zastre JA,Hanberry BS,Sweet RL,McGinnis AC,Venuti KR,Bartlett MG,Govindarajan R
MA5-15739 was used in western blot to determine whether vitamin B1 homeostasis is altered in breast cancer
Sun Sep 01 00:00:00 EDT 2013
Follicle-stimulating hormone inhibits apoptosis in ovarian cancer cells by regulating the OCT4 stem cell signaling pathway.
International journal of oncology
Zhang Z,Zhu Y,Lai Y,Wu X,Feng Z,Yu Y,Bast RC,Wan X,Xi X,Feng Y
MA5-15739 was used in western blot to study the role of the OCT4 stem cell pathway in the mechanism by which FSH inhibits ovarian cancer cell apoptosis and the therapeutic implications
Tue Oct 01 00:00:00 EDT 2013
Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt.
World journal of gastroenterology
Deng G,Huang XJ,Luo HW,Huang FZ,Liu XY,Wang YH
MA5-15739 was used in western blot to study whether treatment with a virus expressing Akt can protect against liver cirrhosis in the rat carbon tetrachloride model
Thu Jul 03 00:00:00 EDT 2014
Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity.
American journal of physiology. Cell physiology
Palenski TL,Gurel Z,Sorenson CM,Hankenson KD,Sheibani N
MA5-15739 was used in western blot to study the role of Cyp1B1 in angiogenesis
Sun Dec 01 00:00:00 EST 2013
TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.
Journal of cell science
Huai J,Vögtle FN,Jöckel L,Li Y,Kiefer T,Ricci JE,Borner C
MA5-15739 was used in western blot to study the mechanisms of TNF?-induced lysosomal membrane permeability
Sun Sep 01 00:00:00 EDT 2013
The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A.
Toxicology and applied pharmacology
Sato S,Shirakawa H,Tomita S,Tohkin M,Gonzalez FJ,Komai M
MA5-15739 was used in western blot to investigate crosstalk between metallothionein 2A and the aryl hydrocarbon receptor
Fri Nov 15 00:00:00 EST 2013
Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome.
Neurogastroenterology and motility
Matricon J,Muller E,Accarie A,Meleine M,Etienne M,Voilley N,Busserolles J,Eschalier A,Lazdunski M,Bourdu S,Gelot A,Ardid D
MA5-15739 was used in western blot to study colonic hypersensitivity in a rat irritable bowel syndrome model and the roles of peripheral NGF and ASIC1a
Fri Nov 01 00:00:00 EDT 2013
Programmed cell death is impaired in the developing brain of FMR1 mutants.
Developmental neuroscience
Cheng Y,Corbin JG,Levy RJ
MA5-15739 was used in western blot to assess apoptosis in the developing brain of FMR1 mutants
Wed Mar 19 00:00:00 EDT 2014
XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress.
Cell reports
Merret R,Descombin J,Juan YT,Favory JJ,Carpentier MC,Chaparro C,Charng YY,Deragon JM,Bousquet-Antonelli C
MA5-15739 was used in western blot to study transcriptome changes in the heat stress response of Arabidopisis
Thu Dec 12 00:00:00 EST 2013
Caveolin-1 associated adenovirus entry into human corneal cells.
PloS one
Yousuf MA,Zhou X,Mukherjee S,Chintakuntlawar AV,Lee JY,Ramke M,Chodosh J,Rajaiya J
MA5-15739 was used in western blot to study HA-dvD endocytosis into corneal cells
Tue Aug 05 00:00:00 EDT 2014
Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle.
The Journal of biological chemistry
Löffler MG,Birkenfeld AL,Philbrick KM,Belman JP,Habtemichael EN,Booth CJ,Castorena CM,Choi CS,Jornayvaz FR,Gassaway BM,Lee HY,Cartee GD,Philbrick W,Shulman GI,Samuel VT,Bogan JS
MA5-15739 was used in western blot to study the increased rate of whole body fasting glucose metabolism in transgenic mice expressing a truncated form of TUG in skeletal muscle
Fri Jul 12 00:00:00 EDT 2013
Modulation of vascular cell function by bim expression.
International journal of cell biology
Morrison ME,Palenski TL,Jamali N,Sheibani N,Sorenson CM
MA5-15739 was used in western blot to study modulation of vascular cell function by bim expression
Fri Nov 29 00:00:00 EST 2013
Insulin receptor signaling in cones.
The Journal of biological chemistry
Rajala A,Dighe R,Agbaga MP,Anderson RE,Rajala RV
MA5-15739 was used in western blot to study the insulin signaling pathway in murine cones
Fri Jul 05 00:00:00 EDT 2013
Effects of adult exposure to bisphenol a on genes involved in the physiopathology of rat prefrontal cortex.
PloS one
Castro B,Sánchez P,Torres JM,Ortega E
MA5-15739-1MG was used in western blot to study the molecular basis for the pathophysiological effects of bisphenol A on the prefrontal cortex of adult rats
Mon May 26 00:00:00 EDT 2014
Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin.
Biochimica et biophysica acta
Berge EO,Huun J,Lillehaug JR,Lønning PE,Knappskog S
MA5-15739 was used in western blot to characterize p53 mutants identified in breast cancers with suboptimal therapeutic reponses
Fri Mar 01 00:00:00 EST 2013
Estrogen inhibits renal cell carcinoma cell progression through estrogen receptor-β activation.
PloS one
Yu CP,Ho JY,Huang YT,Cha TL,Sun GH,Yu DS,Chang FW,Chen SP,Hsu RJ
MA5-15739 was used in western blot to study the role of ER-beta activation in the mechanism by which estrogen inhibits the progression of renal cell carcinoma
Tue Sep 03 00:00:00 EDT 2013
Upregulation of proapoptotic microRNA mir-125a after massive small bowel resection in rats.
Annals of surgery
Balakrishnan A,Stearns AT,Park PJ,Dreyfuss JM,Ashley SW,Rhoads DB,Tavakkolizadeh A
MA5-15739 was used in western blot to study the ability of major bowel resection to dramatically upregulate apoptosis-inducing miRNA-125a in a rat model
Sun Apr 01 00:00:00 EDT 2012
Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans.
Diabetes
Stull AJ,Wang ZQ,Zhang XH,Yu Y,Johnson WD,Cefalu WT
MA5-15739 was used in western blot to determine the relationship between skeletal muscle PTP1B and whole-body insulin sensitivity
Fri Jun 01 00:00:00 EDT 2012
Acute lung inflammatory response and injury after hemorrhagic shock are more severe in postpartum rabbits.
Critical care medicine
Sheng C,Yu YH,Zhao KS,Huang LP,Lodato RF,Wang ZJ,Wang CH,Wang SH,Zha DS
MA5-15739 was used in western blot to study acute respiratory distress syndrome in post-partum rabbits following hemorrhagic shock
Tue May 01 00:00:00 EDT 2012
Replication of minute virus of mice in murine cells is facilitated by virally induced depletion of p21.
Journal of virology
Adeyemi RO,Pintel DJ
MA5-15739 was used in Western Blotting to elucidate the mechanisms facilitating the replication of minute virus of mice in murine cells.
Wed Aug 01 00:00:00 EDT 2012
Tripchlorolide induces cell death in lung cancer cells by autophagy.
International journal of oncology
Chen L,Liu Q,Huang Z,Wu F,Li Z,Chen X,Lin T
MA5-15739 was used in western blot to study the ability of tripchlorolide to promote lung cancer cell death via the induction of autophagy
Sun Apr 01 00:00:00 EDT 2012
Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue.
Arthritis research & therapy
Gheorghe KR,Sadique S,Leclerc P,Idborg H,Wobst I,Catrina AI,Jakobsson PJ,Korotkova M
MA5-15739 was used in western blot to study the lack of effect of glucocorticoids and methotrexate on the expression of 15-prostaglandin dehydrogenase in the synovial tissue of rheumatoid arthritis patients
Tue May 22 00:00:00 EDT 2012
Hsp40 regulates the amount of keratin proteins via ubiquitin-proteasome pathway in cultured human cells.
International journal of molecular medicine
Yamazaki S,Uchiumi A,Katagata Y
MA5-15739 was used in western blot to gain insights into the regulation of keratins
Wed Feb 01 00:00:00 EST 2012
Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.
Endocrinology
Tanaka Y,Park JH,Tanwar PS,Kaneko-Tarui T,Mittal S,Lee HJ,Teixeira JM
MA5-15739 was used in western blot to examine whether conditional deletion of tuberous sclerosis 1 affects fertility in female mice
Sun Jan 01 00:00:00 EST 2012
Cholesterol-lowering drugs inhibit lectin-like oxidized low-density lipoprotein-1 receptor function by membrane raft disruption.
Molecular pharmacology
Matarazzo S,Quitadamo MC,Mango R,Ciccone S,Novelli G,Biocca S
MA5-15739 was used in western blot to investigate the mechanisms by which statins disrupt LOX-1 function
Wed Aug 01 00:00:00 EDT 2012
Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis.
Journal of proteomics
Thouvenot E,Urbach S,Vigy O,Séveno M,Galéotti N,Nguyen G,Bockaert J,Marin P
MA5-15739 was used in western blot to identify variations in protein release by neurons during apoptosis
Fri Dec 21 00:00:00 EST 2012
Pentamidine sensitizes chronic myelogenous leukemia K562 cells to TRAIL-induced apoptosis.
Leukemia research
Qiu G,Jiang J,Liu XS
MA5-15739 was used in western blot to study the effects of pentamidine on leukemia cell lines
Thu Nov 01 00:00:00 EDT 2012
Androgens inhibit tumor necrosis factor-α-induced cell adhesion and promote tube formation of human coronary artery endothelial cells.
Steroids
Liao CH,Lin FY,Wu YN,Chiang HS
MA5-15739 was used in western blot to study the mechanisms by which androgens modulate human coronary artery endothelial cell function
Fri Jun 01 00:00:00 EDT 2012
Downregulation of keratins 8, 18 and 19 influences invasiveness of human cultured squamous cell carcinoma and adenocarcinoma cells.
Experimental and therapeutic medicine
Uchiumi A,Yamashita M,Katagata Y
MA5-15739 was used in western blot to examine the relation between keratins and invasiveness of squamous cell carcinoma and adenocarcinoma cells
Thu Mar 01 00:00:00 EST 2012
GroEL1, from Chlamydia pneumoniae, induces vascular adhesion molecule 1 expression by p37(AUF1) in endothelial cells and hypercholesterolemic rabbit.
PloS one
Huang CY,Shih CM,Tsao NW,Chen YH,Li CY,Chang YJ,Chang NC,Ou KL,Lin CY,Lin YW,Nien CH,Lin FY
MA5-15739 was used in western blot to study the mechanisms by which Clamydia pneumonia GroEL1 induces VCAM-1 expression and promotes atherogenesis
Fri Mar 22 00:00:00 EDT 2013
Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells.
PloS one
Vanoverberghe K,Lehen'kyi V,Thébault S,Raphaël M,Vanden Abeele F,Slomianny C,Mariot P,Prevarskaya N
MA5-15739 was used in western blot to study the modulation of store-operated calcium entry by cytoskeletal reorganization in cells that have undergone neuroendocrine-differentiation
Tue May 07 00:00:00 EDT 2013
Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice.
International journal of nanomedicine
Wang ZQ,Yu Y,Zhang XH,Floyd ZE,Boudreau A,Lian K,Cefalu WT
MA5-15739 was used in western blot to compare the effects of dietary fibers on hepatic cellular signaling in mice.
Thu Jan 24 00:00:00 EST 2013
Down-regulation of the PI3K/Akt signaling pathway and induction of apoptosis in CA46 Burkitt lymphoma cells by baicalin.
Journal of experimental & clinical cancer research : CR
Huang Y,Hu J,Zheng J,Li J,Wei T,Zheng Z,Chen Y
MA5-15739 was used in western blot to study the ability of the flavone baicalin to downregulate PI3 kinase/Akt signaling and induce apoptosis in Burkitt lymphoma cells
Sun May 20 00:00:00 EDT 2012
NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Cardiovascular research
Radwański PB,Poelzing S
MA5-15739 was used in western blot to investigate the involvement of NCX in arrhythmias in a model of Andersen-Tawil syndrome
Sat Oct 01 00:00:00 EDT 2011
An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.
The Journal of nutritional biochemistry
Wang ZQ,Ribnicky D,Zhang XH,Zuberi A,Raskin I,Yu Y,Cefalu WT
MA5-15739 was used in western blot to investigate the effect of Artemisia dracunculus L. extract PMI 5011 on insulin sensitivity and insulin receptor signaling
Sat Jan 01 00:00:00 EST 2011
Co-expression of laminin β3 and γ2 chains and epigenetic inactivation of laminin α3 chain in gastric cancer.
International journal of oncology
Ii M,Yamamoto H,Taniguchi H,Adachi Y,Nakazawa M,Ohashi H,Tanuma T,Sukawa Y,Suzuki H,Sasaki S,Imai K,Shinomura Y
MA5-15739 was used in western blot to clarify alterations of LM-332 in gastric carcinoma
Thu Sep 01 00:00:00 EDT 2011
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
The American journal of pathology
Palmer K,Saglam B,Whitehead C,Stock O,Lappas M,Tong S
MA5-15739 was used in western blot to investigate the placental expression of COMT in preeclampsia
Wed Jun 01 00:00:00 EDT 2011
Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts.
Arthritis research & therapy
Turner-Brannen E,Choi KY,Lippert DN,Cortens JP,Hancock RE,El-Gabalawy H,Mookherjee N
MA5-15739 was used in western blot to examine the impact of IDR-1002 on IL?-induced inflammatory responses
Thu Aug 11 00:00:00 EDT 2011
Lipid metabolism and peroxisome proliferator-activated receptor signaling pathways participate in late-phase liver regeneration.
Journal of proteome research
Yuan X,Yan S,Zhao J,Shi D,Yuan B,Dai W,Jiao B,Zhang W,Miao M
MA5-15739 was used in western blot to study the mechanisms of late-phase liver regeneration
Fri Mar 04 00:00:00 EST 2011
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression.
American journal of physiology. Heart and circulatory physiology
Han P,Cai W,Wang Y,Lam CK,Arvanitis DA,Singh VP,Chen S,Zhang H,Zhang R,Cheng H,Kranias EG
MA5-15739 was used in western blot to investigate the relationship between histidine-rich calcium binding protein HRC S96A variant overexpression and human arrhythmias
Sat Oct 01 00:00:00 EDT 2011
Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.
Investigative ophthalmology & visual science
Ivanovic I,Anderson RE,Le YZ,Fliesler SJ,Sherry DM,Rajala RV
MA5-15739 was used in western blot to investigate the role of phosphoinositide 3-kinase p85alpha subunit for the development and survival of cone photoreceptors
Wed Jun 01 00:00:00 EDT 2011
Targeting prostate cancer angiogenesis through metastasis-associated protein 1 (MTA1).
The Prostate
Kai L,Wang J,Ivanovic M,Chung YT,Laskin WB,Schulze-Hoepfner F,Mirochnik Y,Satcher RL,Levenson AS
MA5-15739 was used in western blot to study the role of MTA-1 overexpression in prostate cancer pathogenesis
Tue Feb 15 00:00:00 EST 2011
The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.
Developmental biology
Sánchez NS,Hill CR,Love JD,Soslow JH,Craig E,Austin AF,Brown CB,Czirok A,Camenisch TD,Barnett JV
MA5-15739 was used in western blot to identify the mechanism by which TGF?R3 signals coronary vessel formation
Sat Oct 15 00:00:00 EDT 2011
Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Neoplasia (New York, N.Y.)
Ou WB,Hubert C,Corson JM,Bueno R,Flynn DL,Sugarbaker DJ,Fletcher JA
MA5-15739 was used in western blot to study the therapeutic potential of inhibiting multiple receptor tyrosone kinases in mesothelioma
Sat Jan 01 00:00:00 EST 2011
Transient receptor potential A1 and cannabinoid receptor activity in human normal and hyperplastic prostate: relation to nerves and interstitial cells.
European urology
Gratzke C,Weinhold P,Reich O,Seitz M,Schlenker B,Stief CG,Andersson KE,Hedlund P
MA5-15739 was used in western blot to study TRPA1 and cannabinoid receptor activity in human prostate
Sat May 01 00:00:00 EDT 2010
Polycomb complexes act redundantly to repress genomic repeats and genes.
Genes & development
Leeb M,Pasini D,Novatchkova M,Jaritz M,Helin K,Wutz A
MA5-15739 was used in western blot to study the redundancy of polycomb repressive complexes-1 and -2 during differentiation of pluripotent embryonic stem cells
Mon Feb 01 00:00:00 EST 2010
Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells.
American journal of obstetrics and gynecology
Zhu XM,Han T,Wang XH,Li YH,Yang HG,Luo YN,Yin GW,Yao YQ
MA5-15739 was used in western blot to study the effects of miR-152 overexpression on human leukocyte antigen-G expression and NK cytolytic activity in a human trophoblast cell line
Tue Jun 01 00:00:00 EDT 2010
Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.
International journal of cancer
Kai L,Samuel SK,Levenson AS
MA5-15739 was used in western blot to study a novel epigenetic mechanism by which resveratol promotes prostate cancer cell apoptosis
Thu Apr 01 00:00:00 EDT 2010
Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity.
Acta pharmacologica Sinica
Ou YQ,Zhu Wb,Li Y,Qiu PX,Huang YJ,Xie J,He SM,Zheng XK,Leng TD,Xu D,Yan GM
MA5-15739 was used in western blot to investigate whether aspirin is able to augment gemcitabine-induced cytotoxicity in human pancreatic cancer cells
Fri Jan 01 00:00:00 EST 2010
Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells.
Vascular pharmacology
Zhu W,He S,Li Y,Qiu P,Shu M,Ou Y,Zhou Y,Leng T,Xie J,Zheng X,Xu D,Su X,Yan G
MA5-15739 was used in western blot to determine the mechanism by which triptolide suppresses angiogenesis of anaplastic thyroid carcinoma
Wed Sep 29 00:00:00 EDT 2010
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Hubbard LL,Ballinger MN,Thomas PE,Wilke CA,Standiford TJ,Kobayashi KS,Flavell RA,Moore BB
MA5-15739 was used in western blot to determine how PGE(2) suppresses pulmonary defenses post-bone marrow transplant
Tue Jun 01 00:00:00 EDT 2010
Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.
Cell cycle (Georgetown, Tex.)
Tavana O,Benjamin CL,Puebla-Osorio N,Sang M,Ullrich SE,Ananthaswamy HN,Zhu C
MA5-15739 was used in western blot to study the effects of absence of p53-dependent apoptosis
Sun Aug 15 00:00:00 EDT 2010
Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan.
Cellular signalling
Craig EA,Parker P,Austin AF,Barnett JV,Camenisch TD
MA5-15739 was used in western blot to study the roles of hyaluronan and MEKK1 in the regulation of epicardial cell fate
Tue Jun 01 00:00:00 EDT 2010
Androgens stimulate telomerase expression, activity and phosphorylation in ovarian adenocarcinoma cells.
Molecular and cellular endocrinology
Nourbakhsh M,Golestani A,Zahrai M,Modarressi MH,Malekpour Z,Karami-Tehrani F
MA5-15739 was used in western blot to investigate the effect of androgens on telomerase in ovarian adenocarcinoma cells
Wed Dec 15 00:00:00 EST 2010
TGFβ2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion.
Experimental cell research
Craig EA,Austin AF,Vaillancourt RR,Barnett JV,Camenisch TD
MA5-15739 was used in western blot to study the role of TGF?2 and hyaluronan during epicardial EMT
Fri Dec 10 00:00:00 EST 2010
Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation.
Toxicology mechanisms and methods
Bhadauria S,Mishra R,Kanchan R,Tripathi C,Srivastava A,Tiwari A,Sharma S
MA5-15739 was used in western blot to identify the key components of the INH-induced apoptotic pathway
Tue Jun 01 00:00:00 EDT 2010
Rimonabant is a dual inhibitor of acyl CoA:cholesterol acyltransferases 1 and 2.
Biochemical and biophysical research communications
Netherland C,Thewke DP
MA5-15739 was used in western blot to study the ability of the CB1 antagonist rimonabant to inhibit ACAT-1 and ACAT-2
Fri Aug 06 00:00:00 EDT 2010
Hypermethylation of HLA class I gene is associated with HLA class I down-regulation in human gastric cancer.
Tissue antigens
Ye Q,Shen Y,Wang X,Yang J,Miao F,Shen C,Zhang J
MA5-15739 was used in western blot to investigate the effect of methylation status on HLA class I expression in cancers
Fri Jan 01 00:00:00 EST 2010
Opposing effects of two tissue transglutaminase protein isoforms in neuroblastoma cell differentiation.
The Journal of biological chemistry
Tee AEL,Marshall GM,Liu PY,Xu N,Haber M,Norris MD,Iismaa SE,Liu T
MA5-15739 was used in western blot to study the effects of tissue transglutaminase protein isoforms in neuroblastoma cell differentiation
Fri Feb 05 00:00:00 EST 2010
Basal and oxidative stress-induced expression of metallothionein is decreased in ascending aortic aneurysms of bicuspid aortic valve patients.
Circulation
Phillippi JA,Klyachko EA,Kenny JP,Eskay MA,Gorman RC,Gleason TG
MA5-15739 was used in western blot to investigate the link between metallothionein and ascending aortic aneurysms
Tue May 12 00:00:00 EDT 2009
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Proceedings of the National Academy of Sciences of the United States of America
Thangarajah H,Yao D,Chang EI,Shi Y,Jazayeri L,Vial IN,Galiano RD,Du XL,Grogan R,Galvez MG,Januszyk M,Brownlee M,Gurtner GC
MA5-15739 was used in western blot to determine whether hypoxic up-regulation of VEGF is impaired in diabetes
Tue Aug 11 00:00:00 EDT 2009
Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder.
The Journal of urology
Gratzke C,Streng T,Park A,Christ G,Stief CG,Hedlund P,Andersson KE
MA5-15739 was used in western blot to study cannabinoid receptors 1 and 2 in the rat, monkey and human bladder
Wed Apr 01 00:00:00 EDT 2009
Size-dependent regulation of Snail2 by hyaluronan: its role in cellular invasion.
Glycobiology
Craig EA,Parker P,Camenisch TD
MA5-15739 was used in western blot to study the signal transduction mechanisms activated by various sized hyaluronans
Sat Aug 01 00:00:00 EDT 2009
IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia.
Stem cells (Dayton, Ohio)
Thangarajah H,Vial IN,Chang E,El-Ftesi S,Januszyk M,Chang EI,Paterno J,Neofytou E,Longaker MT,Gurtner GC
MA5-15739 was used in western blot to study the ability of hypoxia to induce a pro-angiogenic phenotype in adipose stromal cells
Thu Jan 01 00:00:00 EST 2009
Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis.
Mediators of inflammation
Fu Y,Wang W,Tong J,Pan Q,Long Y,Qian W,Hou X
MA5-15739 was used in western blot to determine whether Th17 cells are involved in the development of gastrointestinal hypermotitility in an experimental model
Wed Feb 24 00:00:00 EST 2010
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.
Molecular pharmacology
Zhu W,Ou Y,Li Y,Xiao R,Shu M,Zhou Y,Xie J,He S,Qiu P,Yan G
MA5-15739 was used in western blot to determine whether triplolide has efficacy against human anaplastic thyroid carcinoma cells
Wed Apr 01 00:00:00 EDT 2009
JNK and p38 were involved in hypoxia and reoxygenation-induced apoptosis of cultured rat cerebellar granule neurons.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
Liu AL,Wang XW,Liu AH,Su XW,Jiang WJ,Qiu PX,Yan GM
MA5-15739 was used in western blot to study the role of JNK and p38 in reperfusion injury in a cultured rat cerebellar granule neuron model of stroke
Sun Mar 01 00:00:00 EST 2009
Homologous recombination but not nucleotide excision repair plays a pivotal role in tolerance of DNA-protein cross-links in mammalian cells.
The Journal of biological chemistry
Nakano T,Katafuchi A,Matsubara M,Terato H,Tsuboi T,Masuda T,Tatsumoto T,Pack SP,Makino K,Croteau DL,Van Houten B,Iijima K,Tauchi H,Ide H
MA5-15739 was used in western blot to study the role of hmologous recombination and nucleotide excision repair in tolerance of DNA-protein cross-links in mammalian cells
Fri Oct 02 00:00:00 EDT 2009
Th17 cells influence intestinal muscle contraction during Trichinella spiralis infection.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
Fu Y,Wang W,Tong J,Pan Q,Long Y,Qian W,Hou X
MA5-15739 was used in western blot to determine whether Th17 cells are involved in the development of gastrointestinal hypermotility
Sat Aug 01 00:00:00 EDT 2009
Induction of ERBB2 nuclear transport after radiation in breast cancer cells.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
Luo B,Yu S,Zhuang L,Xia S,Zhao Z,Rong L
MA5-15739 was used in western blot to investigate the nuclear transport of ERBB2 in breast cancer cells after radiation
Mon Jun 01 00:00:00 EDT 2009
Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis.
Cancer research
Li Z,Jiang J,Wang Z,Zhang J,Xiao M,Wang C,Lu Y,Qin Z
MA5-15739 was used in western blot to investigate the significance of interleukin-4 upregulation in tumor cells
Sat Nov 01 00:00:00 EDT 2008
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages.
PLoS biology
Chiu SY,Asai N,Costantini F,Hsu W
MA5-15739 was used in western blot to investigate the influence of SUMO-specific protease 2 on trophoblast lineage development
Tue Dec 16 00:00:00 EST 2008
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1.
Molecular pharmacology
Chen HH,Song IS,Hossain A,Choi MK,Yamane Y,Liang ZD,Lu J,Wu LY,Siddik ZH,Klomp LW,Savaraj N,Kuo MT
MA5-15739 was used in western blot to study mechanisms of cellular sensitization to cisplatin toxicity
Mon Sep 01 00:00:00 EDT 2008
Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells.
Molecular pharmacology
Song IS,Chen HH,Aiba I,Hossain A,Liang ZD,Klomp LW,Kuo MT
MA5-15739 was used in western blot to investigate the regulation of copper homeostasis in mammalian cells
Mon Sep 01 00:00:00 EDT 2008
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans.
The Journal of experimental medicine
An G,Wei B,Xia B,McDaniel JM,Ju T,Cummings RD,Braun J,Xia L
MA5-15739 was used in western blot to study the role of intestinal core 3 O-glycans in the susceptibility of mice to colitis and colorectal cancer
Mon Jun 11 00:00:00 EDT 2007
Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis.
Acta pharmacologica Sinica
Cao L,Cao DX,Su XW,Chen LJ,Liu AL,Jian WJ,Wu YP,Qiu PX,Yan GM
MA5-15739 was used in western blot to study the role of PI3 kinase/Akt pathway activation in protecting cultured cerebellar granule neurons against low K(+)-induced apoptosis
Thu Feb 01 00:00:00 EST 2007
Regulation of sarco/endoplasmic and plasma membrane calcium ATPase gene expression by calcium in cultured human lens epithelial cells.
Cell calcium
Marian MJ,Mukhopadhyay P,Borchman D,Tang D,Paterson CA
MA5-15739 was used in western blot to study the effect of calcium on the expression of the PMCA and SERCA Ca(2+)-ATPases in a human lens epithelial cell line
Mon Jan 01 00:00:00 EST 2007
Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells.
Cancer research
Thebault S,Flourakis M,Vanoverberghe K,Vandermoere F,Roudbaraki M,Lehen'kyi V,Slomianny C,Beck B,Mariot P,Bonnal JL,Mauroy B,Shuba Y,Capiod T,Skryma R,Prevarskaya N
MA5-15739 was used in western blot to study the role of TRPC6 channels in agonist-induced Ca(2+) entry and prostate cancer epithelial cell proliferation
Wed Feb 15 00:00:00 EST 2006
Mouse opsin promoter-directed Cre recombinase expression in transgenic mice.
Molecular vision
Le YZ,Zheng L,Zheng W,Ash JD,Agbaga MP,Zhu M,Anderson RE
MA5-15739 was used in western blot to generate mouse opsin promoter-controlled Cre transgenic mice
Tue Apr 18 00:00:00 EDT 2006
Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells.
Pharmacological research
Yang DS,Miao XD,Ye ZM,Feng J,Xu RZ,Huang X,Ge FF
MA5-15739 was used in western blot to study the mechanism by which aurin induces apoptosis in human osteosarcoma U2OS cells
Tue Nov 01 00:00:00 EST 2005
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
Journal of neuroinflammation
Ehrhart J,Obregon D,Mori T,Hou H,Sun N,Bai Y,Klein T,Fernandez F,Tan J,Shytle RD
MA5-15739 was used in western blot to study the effect of CB2 stimulation on microglial activation
Mon Dec 12 00:00:00 EST 2005
Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhang X,Li Y,Huang Q,Wang H,Yan B,Dewhirst MW,Li CY
MA5-15739 was used in western blot to study the mechanisms by which integrin-linked kinase overexpresson increases the resistance of tumour cells to hyperthermia
Sat Mar 01 00:00:00 EST 2003
Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
Circulation
Zhang X,Hu K,Li CY
MA5-15739 was used in western blot to study the ability of integrin-linked kinase overexpression to prevent oxidized LDL-induced vascular endothelial cell death
Tue Dec 04 00:00:00 EST 2001
