Product References
Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells.
Science advances
Petrelli F,Scandella V,Montessuit S,Zamboni N,Martinou JC,Knobloch M
MA3-028 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to highlight the importance of metabolism for NSPC regulation and identify an important pathway through which mitochondrial pyruvate import controls NSPC quiescence and activation.
Wed Mar 01 00:00:00 EST 2023
Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues.
International journal of molecular sciences
Solier S,Mondini M,Meziani L,Jacquel A,Lacout C,Berghe TV,Julé Y,Martinou JC,Pierron G,Rivière J,Deloger M,Dupuy C,Slama-Schwok A,Droin N,Vandenabeele P,Auberger P,Deutsch E,El-Benna J,Dang PM,Solary E
MA3-028 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Sample Prep to demonstrate that activated caspase-3 and caspase-7 are located to the vicinity of the mitochondria in CSF1-treated human monocytes.
Sun Feb 19 00:00:00 EST 2023
Carnosinase-1 Knock-Out Reduces Kidney Fibrosis in Type-1 Diabetic Mice on High Fat Diet.
Antioxidants (Basel, Switzerland)
Pfeffer T,Wetzel C,Kirschner P,Bartosova M,Poth T,Schwab C,Poschet G,Zemva J,Bulkescher R,Damgov I,Thiel C,Garbade SF,Klingbeil K,Peters V,Schmitt CP
MA3-028 was used in Western Blotting to investigate the effects of carnosine and anserine supplementation in diabetic nephropathy in mice.
Wed Jun 14 00:00:00 EDT 2023
Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes.
Genome biology
Soto I,Couvillion M,Hansen KG,McShane E,Moran JC,Barrientos A,Churchman LS
MA3-028 was used in Western Blotting to propose that human OXPHOS complexes are synthesized proportionally to each other, with mitonuclear balance relying on the regulation of OXPHOS subunit translation across cellular compartments, which may represent a proteostasis vulnerability.
Tue Aug 09 00:00:00 EDT 2022
A neurogenic signature involving monoamine Oxidase-A controls human thermogenic adipose tissue development.
eLife
Solivan-Rivera J,Yang Loureiro Z,DeSouza T,Desai A,Pallat S,Yang Q,Rojas-Rodriguez R,Ziegler R,Skritakis P,Joyce S,Zhong D,Nguyen T,Corvera S
MA3-028 was used in Immunohistochemistry-immunofluorescence to reveal species-specific cell type dependencies controlling the development of thermogenic adipose tissue and point to human adipocyte MAOA as a potential target for metabolic disease therapy.
Thu Sep 15 00:00:00 EDT 2022
Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases.
Frontiers in pharmacology
Suárez-Rivero JM,Pastor-Maldonado CJ,Romero-González A,Gómez-Fernandez D,Povea-Cabello S,Álvarez-Córdoba M,Villalón-García I,Talaverón-Rey M,Suárez-Carrillo A,Munuera-Cabeza M,Sánchez-Alcázar JA
MA3-028 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to identify a potentially beneficial molecule, pterostilbene (a resveratrol analogue), as mitochondrial booster in drug screenings.
Tue Apr 05 00:00:00 EDT 2022
Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions.
Frontiers in cell and developmental biology
Biswas H,Zhao SJ,Makinwa Y,Bassett JS,Musich PR,Liu JY,Zou Y
MA3-028 was used in Proximity Ligation Assay (PLA) to suggest that the isomerization-induced structural changes of ATR define both its subcellular location and compartment-specific functions and play an essential role in promoting cell survival and DNA damage responses.
Sun Oct 08 00:00:00 EDT 2023
Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism.
Nature communications
Katona M,Bartók Á,Nichtova Z,Csordás G,Berezhnaya E,Weaver D,Ghosh A,Várnai P,Yule DI,Hajnóczky G
MA3-028 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, STORM Imaging to show means to visualize the capture of motile IP3 receptors (IP3Rs) at ERMCs and document the immediate consequences for calcium signaling and metabolism.
Wed Nov 09 00:00:00 EST 2022
UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases.
Orphanet journal of rare diseases
Suárez-Rivero JM,Pastor-Maldonado CJ,Povea-Cabello S,Álvarez-Córdoba M,Villalón-García I,Talaverón-Rey M,Suárez-Carrillo A,Munuera-Cabeza M,Reche-López D,Cilleros-Holgado P,Piñero-Perez R,Sánchez-Alcázar JA
MA3-028 was used in Western Blotting to provide compelling evidence to propose the activation of intrinsic cellular compensatory mechanisms as promising therapeutic strategy for mitochondrial diseases.
Tue May 17 00:00:00 EDT 2022
The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.
EMBO reports
Brunet MA,Jacques JF,Nassari S,Tyzack GE,McGoldrick P,Zinman L,Jean S,Robertson J,Patani R,Roucou X
MA3-028 was used in Western Blotting to demonstrate that FUS is a bicistronic gene and suggests that both proteins, FUS and altFUS, cooperate in toxic mechanisms.
Thu Jan 07 00:00:00 EST 2021
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling.
Frontiers in cell and developmental biology
Cartes-Saavedra B,Macuada J,Lagos D,Arancibia D,Andrés ME,Yu-Wai-Man P,Hajnóczky G,Eisner V
MA3-028 was used in Western Blot to study the possible outcomes of OPA1 and its ADOA-linked mutations in Ca2+ homeostasis using rescue and overexpression strategies in Opa1-deficient and wild-type murine embryonic fibroblasts (MEFs), respectively and in human ADOA-derived fibroblasts.
Wed Feb 16 00:00:00 EST 2022
His domain protein tyrosine phosphatase and Rabaptin-5 couple endo-lysosomal sorting of EGFR with endosomal maturation.
Journal of cell science
Parkinson G,Roboti P,Zhang L,Taylor S,Woodman P
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Immunocytochemistry
Mon Nov 01 00:00:00 EDT 2021
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs.
Nature communications
Todkar K,Chikhi L,Desjardins V,El-Mortada F,Pépin G,Germain M
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Mar 30 00:00:00 EDT 2021
Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells.
Cell death & disease
Lopez-Crisosto C,Díaz-Vegas A,Castro PF,Rothermel BA,Bravo-Sagua R,Lavandero S
MA3-028 was used in Immunocytochemistry-immunofluorescence to test a hypothesis that mitochondrial stress favors an expansion of functional contacts between mitochondria and ER, thereby increasing mitochondrial metabolism as part of a protective response.
Mon Jun 28 00:00:00 EDT 2021
STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion.
Frontiers in cell and developmental biology
Li C,Liu J,Hou W,Kang R,Tang D
MA3-028 was used in Western Blotting to show that the ER protein STING1 (also known as STING or TMEM173) promotes ferroptosis in human pancreatic cancer cell lines by increasing MFN1/2-dependent mitochondrial fusion, but not mitophagy-mediated mitochondrial removal.
Fri Jul 02 00:00:00 EDT 2021
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration.
Cell research
Zhou S,Zhang W,Cai G,Ding Y,Wei C,Li S,Yang Y,Qin J,Liu D,Zhang H,Shao X,Wang J,Wang H,Yang W,Wang H,Chen S,Hu P,Sun L
MA3-028 was used in Western Blotting to indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration.
Tue Dec 01 00:00:00 EST 2020
Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics.
Nature cell biology
Rey T,Zaganelli S,Cuillery E,Vartholomaiou E,Croisier M,Martinou JC,Manley S
MA3-028 was used in Immunocytochemistry to investigate the internal architecture of MRGs using fluorescence super-resolution localization microscopy and correlative electron microscopy, and found that the MRG ultrastructure consists of compacted RNA embedded within a protein cloud.
Thu Oct 01 00:00:00 EDT 2020
PP2A Regulates Phosphorylation-Dependent Isomerization of Cytoplasmic and Mitochondrial-Associated ATR by Pin1 in DNA Damage Responses.
Frontiers in cell and developmental biology
Makinwa Y,Cartwright BM,Musich PR,Li Z,Biswas H,Zou Y
MA3-028 was used in Western Blotting to report that Pin1's activity on cis ATR requires the phosphorylation of the S428 residue of ATR and describe the molecular mechanism by which Pin1-mediated ATR isomerization in the cytoplasm is regulated.
Fri Oct 02 00:00:00 EDT 2020
PP2A Regulates Phosphorylation-Dependent Isomerization of Cytoplasmic and Mitochondrial-Associated ATR by Pin1 in DNA Damage Responses.
Frontiers in cell and developmental biology
Makinwa Y,Cartwright BM,Musich PR,Li Z,Biswas H,Zou Y
MA3-028 was used in Western Blotting to report that Pin1's activity on cis ATR requires the phosphorylation of the S428 residue of ATR and describe the molecular mechanism by which Pin1-mediated ATR isomerization in the cytoplasm is regulated.
Fri Oct 02 00:00:00 EDT 2020
OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation.
Nature communications
Sharanek A,Burban A,Laaper M,Heckel E,Joyal JS,Soleimani VD,Jahani-Asl A
MA3-028 was used in Western Blotting to show that suppression of OSMR improves glioblastoma response to IR and prolongs lifespan.
Mon Aug 17 00:00:00 EDT 2020
BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.
Cell death & disease
Pedley R,King LE,Mallikarjun V,Wang P,Swift J,Brennan K,Gilmore AP
MA3-028 was used in Western Blot, Immunocytochemistry to identify regulators of apoptotic priming in mitosis, using Bid as bait.
Fri Oct 16 00:00:00 EDT 2020
BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.
Cell death & disease
Pedley R,King LE,Mallikarjun V,Wang P,Swift J,Brennan K,Gilmore AP
MA3-028 was used in Western Blot, Immunocytochemistry to identify regulators of apoptotic priming in mitosis, using Bid as bait.
Fri Oct 16 00:00:00 EDT 2020
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
Nutrients
Monsalves-Alvarez M,Morales PE,Castro-Sepulveda M,Sepulveda C,Rodriguez JM,Chiong M,Eisner V,Lavandero S,Troncoso R
MA3-028 was used in Western Blotting to suggest that short, but not long-term, β-hydroxybutyrate supplementation increases exercise capacity, associated with modifications in mitochondrial morphology and function in mouse skeletal muscle.
Mon Jun 29 00:00:00 EDT 2020
Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473.
Nature metabolism
Tran KV,Brown EL,DeSouza T,Jespersen NZ,Nandrup-Bus C,Yang Q,Yang Z,Desai A,Min SY,Rojas-Rodriguez R,Lundh M,Feizi A,Willenbrock H,Larsen TJ,Severinsen MCK,Malka K,Mozzicato AM,Deshmukh AS,Emanuelli B,Pedersen BK,Fitzgibbons T,Scheele C,Corvera S,Nielsen S
MA3-028 was used in Immunocytochemistry to show that human thermogenic adipocytes specifically express a primate-specific long non-coding RNA, LINC00473 which is highly correlated with UCP1 expression and decreased in obesity and type-2 diabetes.
Fri May 01 00:00:00 EDT 2020
Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Patten DA,Ouellet M,Allan DS,Germain M,Baird SD,Harper ME,Richardson RB
MA3-028 was used in Western Blotting to hypothesize that mitochondrial remodeling, comprising both structural and functional alterations, following ionizing radiation may underlie some of the tenets of radiobiology.
Thu Aug 01 00:00:00 EDT 2019
Hypoxia induces rapid, STAT3 and ROS dependent, mitochondrial translocation of RelA(p65) and IκBα.
Bioscience reports
Ivanova IG,Perkins ND
MA3-028 was used in Western Blotting to show that only the RelA NF-κB subunit and its inhibitor IκBα reside within mitochondria, whilst p50 is found in the endoplasmic reticulum (ER).
Mon Sep 30 00:00:00 EDT 2019
Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.
Cell reports
Debattisti V,Horn A,Singh R,Seifert EL,Hogarth MW,Mazala DA,Huang KT,Horvath R,Jaiswal JK,Hajnóczky G
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Oct 29 00:00:00 EDT 2019
Identification of calnexin as a diacylglycerol acyltransferase-2 interacting protein.
PloS one
Brandt C,McFie PJ,Vu H,Chumala P,Katselis GS,Stone SJ
MA3-028 was used in Western Blotting to identify calnexin as a diacylglycerol acyltransferase-2 interacting protein.
Fri Oct 18 00:00:00 EDT 2019
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
The Journal of biological chemistry
Lomash RM,Petralia RS,Holtzclaw LA,Tsuda MC,Wang YX,Badger JD,Cameron HA,Youle RJ,Roche KW
MA3-028 was used in Immunocytochemistry-immunoflourescence to conclude that the brain-specific dynamin GTPase neurolastin exhibits stress-responsive localization to mitochondria and is required for proper mitochondrial morphology.
Fri Jul 26 00:00:00 EDT 2019
Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.
Small GTPases
Patil H,Yoon D,Bhowmick R,Cai Y,Cho KI,Ferreira PA
MA3-028 was used in Western Blotting to support that Ran GTPase-dependent and independent and moonlighting roles of Ranbp2 or domains thereof and ubc9 control selectively age-dependent, neural-type and mitochondrial functions.
Fri Mar 01 00:00:00 EST 2019
Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism.
Cell death & disease
Naghdi S,Slovinsky WS,Madesh M,Rubin E,Hajnóczky G
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Oct 09 00:00:00 EDT 2018
The Protein Coded by a Short Open Reading Frame, Not by the Annotated Coding Sequence, Is the Main Gene Product of the Dual-Coding Gene MIEF1.
Molecular & cellular proteomics : MCP
Delcourt V,Brunelle M,Roy AV,Jacques JF,Salzet M,Fournier I,Roucou X
MA3-028 was used in Western Blotting to determine levels of both proteins encoded by MIEF1 in two human cells lines and in human colon.
Sat Dec 01 00:00:00 EST 2018
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.
Free radical biology & medicine
Blecha J,Novais SM,Rohlenova K,Novotna E,Lettlova S,Schmitt S,Zischka H,Neuzil J,Rohlena J
MA3-028 was used in SDS-PAGE to report that quiescent cells, despite increased utilization of the ETC and enhanced supercomplex assembly, are less susceptible to cell death induced by ETC disruption when glucose is not limiting.
Wed Nov 01 00:00:00 EDT 2017
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer.
Antioxidants & redox signaling
Rohlenova K,Sachaphibulkij K,Stursa J,Bezawork-Geleta A,Blecha J,Endaya B,Werner L,Cerny J,Zobalova R,Goodwin J,Spacek T,Alizadeh Pesdar E,Yan B,Nguyen MN,Vondrusova M,Sobol M,Jezek P,Hozak P,Truksa J,Rohlena J,Dong LF,Neuzil J
MA3-028 was used in Western Blotting to investigate whether disruption of the electron transport chain is a viable strategy to eliminate Her2high disease.
Tue Jan 10 00:00:00 EST 2017
Drug Library Screening for the Identification of Ionophores That Correct the Mistrafficking Disorder Associated with Oxalosis Kidney Disease.
SLAS discovery : advancing life sciences R & D
Hou S,Madoux F,Scampavia L,Janovick JA,Conn PM,Spicer TP
MA3-028 was used in Western Blotting to study a cell-based high-content assay to identify potential pharmacoperones for the treatment of oxalosis kidney disease.
Tue Aug 01 00:00:00 EDT 2017
Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.
PloS one
Liu T,Krysiak K,Shirai CL,Kim S,Shao J,Ndonwi M,Walter MJ
MA3028 was used in western blot to determine that HSPA9 knockdown is associated with increased TP53 expression and activity
Fri Aug 25 00:00:00 EDT 2017
The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules.
The Journal of biological chemistry
Zaganelli S,Rebelo-Guiomar P,Maundrell K,Rozanska A,Pierredon S,Powell CA,Jourdain AA,Hulo N,Lightowlers RN,Chrzanowska-Lightowlers ZM,Minczuk M,Martinou JC
MA3-028 was used in western blot to identify components of mitochondrial RNA granules
Fri Mar 17 00:00:00 EDT 2017
Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey.
PloS one
Dunham J,van de Vis R,Bauer J,Wubben J,van Driel N,Laman JD,'t Hart BA,Kap YS
MA3-028 was used in Immunocytochemistry to indicate that pathogenic mechanisms in the rhesus monkey experimental autoimmune encephalomyelitis model may in the end lead to induction of oxidative stress and injury.
Mon Dec 11 00:00:00 EST 2017
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice.
Nature medicine
Min SY,Kady J,Nam M,Rojas-Rodriguez R,Berkenwald A,Kim JH,Noh HL,Kim JK,Cooper MP,Fitzgibbons T,Brehm MA,Corvera S
MA3-028 was used in immunocytochemistry to study human 'brite/beige' adipocytes and how they develop from capillary networks and how their implantation improves metabolic homeostasis in mice
Tue Mar 01 00:00:00 EST 2016
Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α.
Cancer research
Lim S,Liu H,Madeira da Silva L,Arora R,Liu Z,Phillips JB,Schmitt DC,Vu T,McClellan S,Lin Y,Lin W,Piazza GA,Fodstad O,Tan M
MA3-028 was used in western blot to study the reprogramming of glucose metabolism in cancer cells by ROS-mediated stabilization of HIF1alpha via the immunoregulatory protein B7-H3
Fri Apr 15 00:00:00 EDT 2016
E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity.
Proceedings of the National Academy of Sciences of the United States of America
Lacroix M,Rodier G,Kirsh O,Houles T,Delpech H,Seyran B,Gayte L,Casas F,Pessemesse L,Heuillet M,Bellvert F,Portais JC,Berthet C,Bernex F,Brivet M,Boutron A,Le Cam L,Sardet C
MA3028 was used in western blot to report that E4F1 is a master regulator of the pyruvate dehydrogenase complex
Tue Sep 27 00:00:00 EDT 2016
Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation.
Biochemical pharmacology
Torres G,Morales PE,García-Miguel M,Norambuena-Soto I,Cartes-Saavedra B,Vidal-Peña G,Moncada-Ruff D,Sanhueza-Olivares F,San Martín A,Chiong M
MA3-028 was used in western blot to elucidate how inhibition of vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation occurs by glucagon-like peptide 1
Tue Mar 15 00:00:00 EDT 2016
FABP-1 gene ablation impacts brain endocannabinoid system in male mice.
Journal of neurochemistry
Martin GG,Chung S,Landrock D,Landrock KK,Huang H,Dangott LJ,Peng X,Kaczocha M,Seeger DR,Murphy EJ,Golovko MY,Kier AB,Schroeder F
MA3-028 was used in western blot to assess the impact of brain endocannabinoid system in male mice by Fabp-1 gene ablation
Mon Aug 01 00:00:00 EDT 2016
Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome.
The Biochemical journal
Brandt C,McFie PJ,Stone SJ
MA3028 was used in western blot to demonstrate that DGAT2 and MGAT2 are substrates of the endoplasmic reticulum-associated degradation pathway
Sat Oct 15 00:00:00 EDT 2016
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Molecular biology of the cell
Mills KM,Brocardo MG,Henderson BR
MA3-028 was used in immunocytochemistry and western blot to report a role for adenomatous polyposis coli in the transport of mitochondria
Mon Feb 01 00:00:00 EST 2016
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Molecular biology of the cell
Mills KM,Brocardo MG,Henderson BR
MA3-028 was used in immunocytochemistry and western blot to report a role for adenomatous polyposis coli in the transport of mitochondria
Mon Feb 01 00:00:00 EST 2016
Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane.
Oncology letters
Gao S,Chen X,Jin H,Ren S,Liu Z,Fang X,Zhang G
MA3-028 was used in western blot to study increased dissociation of hexokinase II from mitochondrial outer membrane by overexpression or ErbB2 rendering breast cancer cells susceptible to 3-BrPA
Mon Feb 01 00:00:00 EST 2016
MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.
The Journal of biological chemistry
Vanderperre B,Cermakova K,Escoffier J,Kaba M,Bender T,Nef S,Martinou JC
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Fri Aug 05 00:00:00 EDT 2016
Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle.
The Journal of biological chemistry
De La Fuente S,Fernandez-Sanz C,Vail C,Agra EJ,Holmstrom K,Sun J,Mishra J,Williams D,Finkel T,Murphy E,Joseph SK,Sheu SS,Csordás G
MA3028 was used in immunohistochemistry and western blot to test if mitochondrial calcium uniporter concentrated at the mitochondria-sarcoplasmic reticulum interface promotes calcium transfer
Fri Oct 28 00:00:00 EDT 2016
Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy.
The Journal of biological chemistry
Akabane S,Matsuzaki K,Yamashita S,Arai K,Okatsu K,Kanki T,Matsuda N,Oka T
MA3-028 was used in western blot to investigate the contribution of PINK1 and PARKIN to cell death
Fri Jul 29 00:00:00 EDT 2016
ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1.
Molecular cell
Hilton BA,Li Z,Musich PR,Wang H,Cartwright BM,Serrano M,Zhou XZ,Lu KP,Zou Y
MA3-028 was used in western blot to investigate the role of mitochondrial ATR during the response to UV damage
Thu Oct 01 00:00:00 EDT 2015
Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.
Journal of the American Society of Nephrology : JASN
Randles MJ,Woolf AS,Huang JL,Byron A,Humphries JD,Price KL,Kolatsi-Joannou M,Collinson S,Denny T,Knight D,Mironov A,Starborg T,Korstanje R,Humphries MJ,Long DA,Lennon R
MA3-028 was used in western blot to determine the strain- and sex-dependent glomerular extracellular matrix signatures.
Tue Dec 01 00:00:00 EST 2015
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Naghdi S,Várnai P,Hajnóczky G
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Oct 13 00:00:00 EDT 2015
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Proceedings of the National Academy of Sciences of the United States of America
Naghdi S,Várnai P,Hajnóczky G
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Oct 13 00:00:00 EDT 2015
The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function.
Cellular signalling
Tembe V,Martino-Echarri E,Marzec KA,Mok MT,Brodie KM,Mills K,Lei Y,DeFazio A,Rizos H,Kettle E,Boadle R,Henderson BR
MA3-028 was used in western blot to describe the localization of BARD1 and study its interaction with p53
Tue Sep 01 00:00:00 EDT 2015
Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling.
Pharmacological reports : PR
Yang N,Han F,Cui H,Huang J,Wang T,Zhou Y,Zhou J
MA3-028 was used in western blot to assess the effect of matrine on STAT3 signaling in cholangiocarcinoma cells
Wed Apr 01 00:00:00 EDT 2015
Effects of chronic cerebral hypoperfusion and low-dose progesterone treatment on apoptotic processes, expression and subcellular localization of key elements within Akt and Erk signaling pathways in rat hippocampus.
Neuroscience
Stanojlović M,Guševac I,Grković I,Zlatković J,Mitrović N,Zarić M,Horvat A,Drakulić D
MA3-028 was used in western blot to assess how chronic cerebral hypoperfusion and repeated low-dose progesterone treatment affect neurodegenerative processes and behavior
Thu Dec 17 00:00:00 EST 2015
Centrosome-intrinsic mechanisms modulate centrosome integrity during fever.
Molecular biology of the cell
Vertii A,Zimmerman W,Ivshina M,Doxsey S
MA3-028 was used in immunocytochemistry to investigate centrosome regulation during fever
Thu Oct 01 00:00:00 EDT 2015
Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.
Experimental hematology
Krysiak K,Tibbitts JF,Shao J,Liu T,Ndonwi M,Walter MJ
MA3-028 was used in western blot to assess the effects of Hspa9 haploinsufficiency on hematopoiesis using zebrafish
Wed Apr 01 00:00:00 EDT 2015
Nanocurcumin Prevents Hypoxia Induced Stress in Primary Human Ventricular Cardiomyocytes by Maintaining Mitochondrial Homeostasis.
PloS one
Nehra S,Bhardwaj V,Ganju L,Saraswat D
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Immunofluorescence
Fri Jun 17 00:00:00 EDT 2016
Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
PLoS genetics
Isbel L,Srivastava R,Oey H,Spurling A,Daxinger L,Puthalakath H,Whitelaw E
MA3-028 was used in western blot to perform a mutagenesis screen for modifiers of epigenetic gene silencing using a cell line with a mutation in Trim33
Tue Dec 01 00:00:00 EST 2015
Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome.
PLoS genetics
Isbel L,Srivastava R,Oey H,Spurling A,Daxinger L,Puthalakath H,Whitelaw E
MA3-028 was used in western blot to perform a mutagenesis screen for modifiers of epigenetic gene silencing using a cell line with a mutation in Trim33
Tue Dec 01 00:00:00 EST 2015
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.
Nature communications
Robertson J,Jacquemet G,Byron A,Jones MC,Warwood S,Selley JN,Knight D,Humphries JD,Humphries MJ
MA3-028 was used in western blot to study phosphorylation events at sites of adhesion
Fri Feb 13 00:00:00 EST 2015
Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
Nature immunology
Odendall C,Dixit E,Stavru F,Bierne H,Franz KM,Durbin AF,Boulant S,Gehrke L,Cossart P,Kagan JC
MA3-028 was used in immunocytochemistry to elucidate type I interferon-independent viral immune responses.
Fri Aug 01 00:00:00 EDT 2014
Promotion of p53 expression and reactive oxidative stress production is involved in zerumbone-induced cisplatin sensitization of non-small cell lung cancer cells.
Biochimie
Hu Z,Zeng Q,Zhang B,Liu H,Wang W
MA3-028 was used in western blot to determine the effect of zerumbone on p53 signaling and assess if zerumbone has anti-cancer effects on non-small cell lung cancer
Mon Dec 01 00:00:00 EST 2014
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.
Autophagy
Jin SM,Youle RJ
MA3-028 was used in Western Blotting to suggest that the accumulation of unfolded proteins in mitochondria is a physiological trigger of mitophagy.
Fri Nov 01 00:00:00 EDT 2013
Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
The Journal of cell biology
Nair R,Lauks J,Jung S,Cooke NE,de Wit H,Brose N,Kilimann MW,Verhage M,Rhee J
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Immunofluorescence
Mon Jan 07 00:00:00 EST 2013
Neurobeachin regulates neurotransmitter receptor trafficking to synapses.
The Journal of cell biology
Nair R,Lauks J,Jung S,Cooke NE,de Wit H,Brose N,Kilimann MW,Verhage M,Rhee J
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Immunofluorescence
Mon Jan 07 00:00:00 EST 2013
Role of p53 in cAMP/PKA pathway mediated apoptosis.
Apoptosis : an international journal on programmed cell death
Rahimi A,Lee YY,Abdella H,Doerflinger M,Gangoda L,Srivastava R,Xiao K,Ekert PG,Puthalakath H
MA3-028 was used in western blot to study the role of p53 in apoptosis mediated by the cAMP/PKA signaling pathway
Sun Dec 01 00:00:00 EST 2013
Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: effects on energy metabolism.
Psychoneuroendocrinology
Adzic M,Lukic I,Mitic M,Djordjevic J,Elaković I,Djordjevic A,Krstic-Demonacos M,Matić G,Radojcic M
MA3-028 was used in western blot to study the influence of gender on the effects of fluoxetine treatment on mitochondrial glucocortocoid receptor phosphorylation in different brain regions of stressed rats
Sun Dec 01 00:00:00 EST 2013
HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.
Molecular cell
Rinaldo C,Moncada A,Gradi A,Ciuffini L,D'Eliseo D,Siepi F,Prodosmo A,Giorgi A,Pierantoni GM,Trapasso F,Guarguaglini G,Bartolazzi A,Cundari E,Schininà ME,Fusco A,Soddu S
MA3-028 was used in western blot to study the role of HIPK2 in the control of cytokinesis and preventing tetraploidization
Fri Jul 13 00:00:00 EDT 2012
Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats.
Progress in neuro-psychopharmacology & biological psychiatry
Djordjevic A,Djordjevic J,Elaković I,Adzic M,Matić G,Radojcic MB
MA3-028 was used in western blot to investigate the effect of fluoxetine on hippocampal plasticity, apoptosis and depressive-like behavior in rats
Tue Jan 10 00:00:00 EST 2012
Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.
The Journal of biological chemistry
Jeanes AI,Wang P,Moreno-Layseca P,Paul N,Cheung J,Tsang R,Akhtar N,Foster FM,Brennan K,Streuli CH
MA3-028 was used in western blot to study the role of the specific beta-containing integrins in the proliferation and migration of mammary epithelial cells
Fri Jul 13 00:00:00 EDT 2012
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.
Nature communications
Ding Y,Liu Z,Desai S,Zhao Y,Liu H,Pannell LK,Yi H,Wright ER,Owen LB,Dean-Colomb W,Fodstad O,Lu J,LeDoux SP,Wilson GL,Tan M
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Jun 11 00:00:00 EDT 2013
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.
Nature communications
Ding Y,Liu Z,Desai S,Zhao Y,Liu H,Pannell LK,Yi H,Wright ER,Owen LB,Dean-Colomb W,Fodstad O,Lu J,LeDoux SP,Wilson GL,Tan M
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Tue Jun 11 00:00:00 EDT 2013
Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing.
Small GTPases
Brooks R,Williamson R,Bass M
MA3-028 was used in western blot to study the mechanism by which syndecan-4 promotes fibroblast migration during wound healing
Wed Apr 03 00:00:00 EDT 2013
Beclin 1-independent autophagy contributes to apoptosis in cortical neurons.
Autophagy
Grishchuk Y,Ginet V,Truttmann AC,Clarke PG,Puyal J
MA3-028 was used in Immunocytochemistry to investigate the role of autophagy in the apoptosis of primary cortical neurons treated with staurosporine.
Sat Oct 01 00:00:00 EDT 2011
Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis.
Molecular cancer research : MCR
Chen X,Wong JY,Wong P,Radany EH
MA3-028 was used in western blot to investigate the mechanism for cancer radiosensitization induced by histone deacetylase inhibitors
Fri Apr 01 00:00:00 EDT 2011
An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Vanderperre B,Staskevicius AB,Tremblay G,McCoy M,O'Neill MA,Cashman NR,Roucou X
MA3-028 was used in immunocytochemistry to study the expression and function of overlapping open reading frames in the prion protein gene PRNP
Fri Jul 01 00:00:00 EDT 2011
Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respectively.
The Journal of biological chemistry
Chung YW,Kim HK,Kim IY,Yim MB,Chock PB
MA3-028 was used in western blot to investigate the effect of PKC on MnSOD expression in human cells
Fri Aug 26 00:00:00 EDT 2011
Different expression of alpha and beta mitochondrial estrogen receptors in the aging rat brain: interaction with respiratory complex V.
Experimental gerontology
Alvarez-Delgado C,Mendoza-Rodríguez CA,Picazo O,Cerbón M
MA3-028 was used in western blot to investigate the distribution of mitochondrial estrogen receptor alpha and beta in the aging rat brain
Sun Aug 01 00:00:00 EDT 2010
Oxidative stress causes reversible changes in mitochondrial permeability and structure.
Experimental gerontology
Cole NB,Daniels MP,Levine RL,Kim G
MA3-028 was used in immunocytochemistry and western blot to investigate the influence of oxidative stress on mitochondrial structure and function
Sun Aug 01 00:00:00 EDT 2010
Chronic social isolation compromises the activity of both glutathione peroxidase and catalase in hippocampus of male wistar rats.
Cellular and molecular neurobiology
Djordjevic J,Djordjevic A,Adzic M,Radojcic MB
MA3-028 was used in western blot to investigate the effect of chronic social isolation on the activity of glutathione peroxidase and catalase in the hippocampus of male wistar rats
Thu Jul 01 00:00:00 EDT 2010
A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.
Journal of Alzheimer's disease : JAD
Amadoro G,Corsetti V,Stringaro A,Colone M,D'Aguanno S,Meli G,Ciotti M,Sancesario G,Cattaneo A,Bussani R,Mercanti D,Calissano P
MA3-028 was used in western blot to investigate the role of a NH2 tau fragment in neuronal mitochondria
Mon Dec 20 00:00:00 EST 2010
Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis.
Oncotarget
Trinh DL,Elwi AN,Kim SW
MA3-028 was used in immunocytochemistry and western blot to study the interaction between Tid1 and p53 and its influence on p53 subcellular localization and apoptosis
Fri Oct 01 00:00:00 EDT 2010
Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis.
Oncotarget
Trinh DL,Elwi AN,Kim SW
MA3-028 was used in immunocytochemistry and western blot to study the interaction between Tid1 and p53 and its influence on p53 subcellular localization and apoptosis
Fri Oct 01 00:00:00 EDT 2010
Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.
The Journal of biological chemistry
Owens TW,Foster FM,Valentijn A,Gilmore AP,Streuli CH
MA3-028 was used in immunocytochemistry and western blot to study the function of X-linked inhibitor of apoptosis protein XIAP during mitochondrial permeabilization
Fri Jan 08 00:00:00 EST 2010
Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization.
The Journal of biological chemistry
Owens TW,Foster FM,Valentijn A,Gilmore AP,Streuli CH
MA3-028 was used in immunocytochemistry and western blot to study the function of X-linked inhibitor of apoptosis protein XIAP during mitochondrial permeabilization
Fri Jan 08 00:00:00 EST 2010
Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria.
Cell cycle (Georgetown, Tex.)
Irvine M,Philipsz S,Frausto M,Mijatov B,Gallagher SJ,Fung C,Becker TM,Kefford RF,Rizos H
MA3-028 was used in western blot to investigate the mitochondrial targeting of p14ARF tumor suppressor
Mon Feb 15 00:00:00 EST 2010
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.
The EMBO journal
Mancini F,Di Conza G,Pellegrino M,Rinaldo C,Prodosmo A,Giglio S,D'Agnano I,Florenzano F,Felicioni L,Buttitta F,Marchetti A,Sacchi A,Pontecorvi A,Soddu S,Moretti F
MA3-028 was used in western blot to study the role of mitochondrial MDM4 in regulating the p53-mediated intrinsic-apoptotic pathway
Wed Jul 08 00:00:00 EDT 2009
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Science signaling
Humphries JD,Byron A,Bass MD,Craig SE,Pinney JW,Knight D,Humphries MJ
MA3-028 was used in western blot to report a method to isolate complexes associated with integrin adhesion receptors
Tue Sep 08 00:00:00 EDT 2009
Mitochondrial Lon protease is a human stress protein.
Free radical biology & medicine
Ngo JK,Davies KJ
MA3-028 was used in western blot to study the induction the mitochondrial Lon protease by multiple cellular stressors and its role as a general stress-protector
Wed Apr 15 00:00:00 EDT 2009
The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats.
The international journal of biochemistry & cell biology
Adzic M,Djordjevic A,Demonacos C,Krstic-Demonacos M,Radojcic MB
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Sun Nov 01 00:00:00 EDT 2009
Calpain 1 and Calpastatin expression is developmentally regulated in rat brain.
Experimental neurology
Li Y,Bondada V,Joshi A,Geddes JW
MA3-028 was used in western blot to investigate the regulation of calpain 1 and calpastatin during rat brain development
Tue Dec 01 00:00:00 EST 2009
Helix 3 is necessary and sufficient for prion protein's anti-Bax function.
Journal of neurochemistry
Laroche-Pierre S,Jodoin J,LeBlanc AC
MA3-028 was used in western blot to study the role of helix 3 in the anti-Bax function of prion protein
Sun Feb 01 00:00:00 EST 2009
Chronic social isolation is related to both upregulation of plasticity genes and initiation of proapoptotic signaling in Wistar rat hippocampus.
Journal of neural transmission (Vienna, Austria : 1996)
Djordjevic A,Adzic M,Djordjevic J,Radojcic MB
MA3-028 was used in western blot to study the effect of chronic social isolation on neuronal plasticity and apoptosis
Tue Dec 01 00:00:00 EST 2009
HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells.
Cancer biotherapy & radiopharmaceuticals
Chen X,Wong P,Radany E,Wong JY
MA3-028 was used in western blot to study the impact of low concentration of valproic acid on radiation response of colorectal cancer cells
Tue Dec 01 00:00:00 EST 2009
Loss of anti-Bax function in Gerstmann-Sträussler-Scheinker syndrome-associated prion protein mutants.
PloS one
Jodoin J,Misiewicz M,Makhijani P,Giannopoulos PN,Hammond J,Goodyer CG,LeBlanc AC
MA3-028 was used in western blot to study the role of the anti-Bax function of PrP in prion disease pathology
Fri Aug 14 00:00:00 EDT 2009
Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma.
Cancer letters
Fujita Y,Nakanishi T,Miyamoto Y,Hiramatsu M,Mabuchi H,Miyamoto A,Shimizu A,Takubo T,Tanigawa N
MA3-028 was used in western blot to investigate an autoantibody against Hsp70 in esophageal squamous cell carcinoma patients
Sun May 18 00:00:00 EDT 2008
Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
The Journal of biological chemistry
Rardin MJ,Wiley SE,Murphy AN,Pagliarini DJ,Dixon JE
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Fri May 30 00:00:00 EDT 2008
Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
The Journal of biological chemistry
Rardin MJ,Wiley SE,Murphy AN,Pagliarini DJ,Dixon JE
Published figure using mtHSP70 monoclonal antibody (Product # MA3-028) in Western Blot
Fri May 30 00:00:00 EDT 2008
Targets of caspase-6 activity in human neurons and Alzheimer disease.
Molecular & cellular proteomics : MCP
Klaiman G,Petzke TL,Hammond J,Leblanc AC
MA3-028 was used in western blot to identify those components regulated by caspase-6 in human neurons
Fri Aug 01 00:00:00 EDT 2008
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice.
The Journal of clinical investigation
Tang X,Zhu Y,Han L,Kim AL,Kopelovich L,Bickers DR,Athar M
MA3-028 was used in immunocytochemistry to indicate that reconstituting p53 tumor suppressor functions may inhibit UVB-induced skin carcinogenesis
Sat Dec 01 00:00:00 EST 2007
The N-terminal conformation of Bax regulates cell commitment to apoptosis.
Cell death and differentiation
Upton JP,Valentijn AJ,Zhang L,Gilmore AP
MA3-028 was used in immunocytochemistry to study the role of Bax N-terminal conformation in controling the commitment to apoptosis
Tue May 01 00:00:00 EDT 2007
Defective retrotranslocation causes loss of anti-Bax function in human familial prion protein mutants.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jodoin J,Laroche-Pierre S,Goodyer CG,LeBlanc AC
MA3-028 was used in western blot to study the mechanism of the anti-Bax function of familial PrP mutants
Wed May 09 00:00:00 EDT 2007
Chronic exposure to sub-lethal beta-amyloid (Abeta) inhibits the import of nuclear-encoded proteins to mitochondria in differentiated PC12 cells.
Journal of neurochemistry
Sirk D,Zhu Z,Wadia JS,Shulyakova N,Phan N,Fong J,Mills LR
MA3-028 was used in western blot to investigate the influence of Abeta on protein transport from nucleus to mitochondira
Sat Dec 01 00:00:00 EST 2007
The Mcf1 toxin induces apoptosis via the mitochondrial pathway and apoptosis is attenuated by mutation of the BH3-like domain.
Cellular microbiology
Dowling AJ,Waterfield NR,Hares MC,Le Goff G,Streuli CH,ffrench-Constant RH
MA3-028 was used in immunocytochemistry to investigate the mechanism for the induction of apoptosis by Mcf1 toxin
Mon Oct 01 00:00:00 EDT 2007
The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.
The Journal of biological chemistry
Yi H,Friedman JL,Ferreira PA
MA3-028 was used in Western Blotting to study how the CLD of RanBP2 acts as a novel auxiliary modulator of the UPS activity.
Fri Nov 30 00:00:00 EST 2007
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.
The Journal of biological chemistry
Ahuja N,Schwer B,Carobbio S,Waltregny D,North BJ,Castronovo V,Maechler P,Verdin E
MA3-028 was used in western blot to study the regulation of insulin secretion by SIRT4
Fri Nov 16 00:00:00 EST 2007
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.
The EMBO journal
Cheung EC,Joza N,Steenaart NA,McClellan KA,Neuspiel M,McNamara S,MacLaurin JG,Rippstein P,Park DS,Shore GC,McBride HM,Penninger JM,Slack RS
MA3-028 was used in western blot to dissociate the dual functions of apoptosis-inducing factor (AIF) in controlling mitochondrial structure and apoptosis
Wed Sep 06 00:00:00 EDT 2006
Molecular morphology and toxicity of cytoplasmic prion protein aggregates in neuronal and non-neuronal cells.
Journal of neurochemistry
Grenier C,Bissonnette C,Volkov L,Roucou X
MA3-028 was used in immunocytochemistry to study the role of cytoplasmic prion protein in prion disease pathogenesis
Thu Jun 01 00:00:00 EDT 2006
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.
The Journal of biological chemistry
Tomita Y,Marchenko N,Erster S,Nemajerova A,Dehner A,Klein C,Pan H,Kessler H,Pancoska P,Moll UM
MA3-028 was used in western blot to study the interaction between wild-type p53 and Bcl2 and its effect on mitochondrial permeabilization.
Fri Mar 31 00:00:00 EST 2006
Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells.
Cell death and differentiation
Roucou X,Giannopoulos PN,Zhang Y,Jodoin J,Goodyer CG,LeBlanc A
MA3-028 was used in western blot to study the inhibition of the proapoptotic Bax conformational change by cellular prion protein in human neurons and breast carcinoma cells
Fri Jul 01 00:00:00 EDT 2005
Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis.
FEBS letters
Nemajerova A,Wolff S,Petrenko O,Moll UM
MA3-028 was used in western blot to study the role of viral and cellular oncogenes in the mitochondrial translocation of p53 in apoptosis
Mon Nov 07 00:00:00 EST 2005
53BP2 induces apoptosis through the mitochondrial death pathway.
Genes to cells : devoted to molecular & cellular mechanisms
Kobayashi S,Kajino S,Takahashi N,Kanazawa S,Imai K,Hibi Y,Ohara H,Itoh M,Okamoto T
MA3-028 was used in western blot to investigate the role of 53BP2 in the mitochondrial death pathway
Tue Mar 01 00:00:00 EST 2005
Hepatitis C virus core protein inhibits mitochondrial electron transport and increases reactive oxygen species (ROS) production.
The Journal of biological chemistry
Korenaga M,Wang T,Li Y,Showalter LA,Chan T,Sun J,Weinman SA
MA3-028 was used in western blot to demonstrate the effect of hepatitis C virus core protein on mitochondrial electron transport and reactive oxygen species production.
Fri Nov 11 00:00:00 EST 2005
Tumor cell pseudopodial protrusions. Localized signaling domains coordinating cytoskeleton remodeling, cell adhesion, glycolysis, RNA translocation, and protein translation.
The Journal of biological chemistry
Jia Z,Barbier L,Stuart H,Amraei M,Pelech S,Dennis JW,Metalnikov P,O'Donnell P,Nabi IR
MA3-028 was used in western blot to demonstrate the role of Rho/ROCK activation in RNA translocation to pseudopodial protrusions in epithelial tumor cells.
Fri Aug 26 00:00:00 EDT 2005
Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss.
Cancer research
Wang J,Ladrech S,Pujol R,Brabet P,Van De Water TR,Puel JL
MA3-028 was used in immunocytochemistry to demonstrate the effect of caspase inhibitors on cisplatin-induced hearing loss.
Wed Dec 15 00:00:00 EST 2004
Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Kaur K,Rani G,Widodo N,Nagpal A,Taira K,Kaul SC,Wadhwa R
MA3-028 was used in immunocytochemistry to investigate the effect of leaf extract from Ashwagandha on cell proliferation and oxidative status
Wed Dec 01 00:00:00 EST 2004
Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies.
Human molecular genetics
Ugalde C,Vogel R,Huijbens R,Van Den Heuvel B,Smeitink J,Nijtmans L
MA3-028 was used in western blot to study the assembly mechanism of human mitochondrial complex I.
Fri Oct 15 00:00:00 EDT 2004
Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival.
Molecular and cellular biology
Lo JF,Hayashi M,Woo-Kim S,Tian B,Huang JF,Fearns C,Takayama S,Zapata JM,Yang Y,Lee JD
MA3-028 was used in immunocytochemistry to study the function of Tid1 during early mammalian development.
Mon Mar 01 00:00:00 EST 2004
A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria.
The Journal of biological chemistry
Ventura A,Maccarana M,Raker VA,Pelicci PG
MA3-028 was used in western blot to investigate the role of p46Shc in the mitochondria-related signal transduction pathways.
Fri Jan 16 00:00:00 EST 2004
Translocation of full-length Bid to mitochondria during anoikis.
The Journal of biological chemistry
Valentijn AJ,Gilmore AP
MA3-028 was used in western blot to investigate the role of Bid in anoikis.
Fri Jul 30 00:00:00 EDT 2004
Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.
The Journal of biological chemistry
Nishitai G,Shimizu N,Negishi T,Kishimoto H,Nakagawa K,Kitagawa D,Watanabe T,Momose H,Ohata S,Tanemura S,Asaka S,Kubota J,Saito R,Yoshida H,Mak TW,Wada T,Penninger JM,Azuma N,Nishina H,Katada T
MA3-028 was used in western blot to investigate the mechanism of the mitochondria-mediated apoptosis in embryonic stem cells.
Fri Jan 16 00:00:00 EST 2004
Spatial and temporal changes in Bax subcellular localization during anoikis.
The Journal of cell biology
Valentijn AJ,Metcalfe AD,Kott J,Streuli CH,Gilmore AP
MA3-028 was used in immunocytochemistry to find the relationship between Bax activation complex formation and apoptosis
Mon Aug 18 00:00:00 EDT 2003
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.
Molecular and cellular biology
Wilson-Fritch L,Burkart A,Bell G,Mendelson K,Leszyk J,Nicoloro S,Czech M,Corvera S
MA3-028 was used in western blot to study the mitochondrial alterations during adipocyte differentiation
Sat Feb 01 00:00:00 EST 2003
The mitochondrial barriers segregate agonist-induced calcium-dependent functions in human airway epithelia.
The Journal of general physiology
Ribeiro CM,Paradiso AM,Livraghi A,Boucher RC
MA3-028 was used in immunocytochemistry to investigate the distribution of mitochondria in polarized human airway epithelia
Wed Oct 01 00:00:00 EDT 2003
Isolation and expression of a novel mitochondrial septin that interacts with CRMP/CRAM in the developing neurones.
Genes to cells : devoted to molecular & cellular mechanisms
Takahashi S,Inatome R,Yamamura H,Yanagi S
MA3-028 was used in immunocytochemistry to identify a CRMP/CRAM interacting protein septin in mitochondria
Sat Feb 01 00:00:00 EST 2003
Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.
Cancer research
Bröker LE,Huisman C,Ferreira CG,Rodriguez JA,Kruyt FA,Giaccone G
MA3-028 was used in western blot to investigate the role of late activation of apoptotic pathway in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells.
Mon Jul 15 00:00:00 EDT 2002
Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Lyu YL,Wang JC
MA3-028 was used in western blot to study mitochondrial and nucleic localization of human DNA topoisomerase IIIalpha.
Tue Sep 17 00:00:00 EDT 2002
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase.
The Journal of cell biology
Schwer B,North BJ,Frye RA,Ott M,Verdin E
MA3-028 was used in western blot to characterize a new mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase .
Mon Aug 19 00:00:00 EDT 2002
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c.
The Journal of biological chemistry
Karpinich NO,Tafani M,Rothman RJ,Russo MA,Farber JL
MA3-028 was used in western blot to investigate the sequence of biochemical events that mediates the apoptosis induced by etoposide.
Fri May 10 00:00:00 EDT 2002
Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.
The Journal of biological chemistry
Chatellard-Causse C,Blot B,Cristina N,Torch S,Missotten M,Sadoul R
MA3-028 was used in immunocytochemistry to investigate the role of Alix during the cytoplasmic vacuolization in apoptosis.
Fri Aug 09 00:00:00 EDT 2002
Glutathione levels and BAX activation during apoptosis due to oxidative stress in cells expressing wild-type and mutant cystic fibrosis transmembrane conductance regulator.
The Journal of biological chemistry
Jungas T,Motta I,Duffieux F,Fanen P,Stoven V,Ojcius DM
MA3-028 was used in immunocytochemistry to investigate what regulates the glutathione levels and BAX activation during apoptosis.
Fri Aug 02 00:00:00 EDT 2002
Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex.
The Journal of biological chemistry
Sargsyan E,Baryshev M,Szekely L,Sharipo A,Mkrtchian S
MA3-028 was used in western blot to investigate the function of ERp29 in thyroid cells.
Fri May 10 00:00:00 EDT 2002
The tripartite motif family identifies cell compartments.
The EMBO journal
Reymond A,Meroni G,Fantozzi A,Merla G,Cairo S,Luzi L,Riganelli D,Zanaria E,Messali S,Cainarca S,Guffanti A,Minucci S,Pelicci PG,Ballabio A
MA3-028 was used in immunocytochemistry to demonstrate that the tripartite motif proteins identify specific cell compartments
Tue May 01 00:00:00 EDT 2001
Calcium regulates the association between mitochondria and a smooth subdomain of the endoplasmic reticulum.
The Journal of cell biology
Wang HJ,Guay G,Pogan L,Sauvé R,Nabi IR
MA3-028 was used in immunocytochemistry to demonstrate the role of calcium in mitochondria and endoplasmic reticulum association.
Mon Sep 18 00:00:00 EDT 2000
TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions.
Proceedings of the National Academy of Sciences of the United States of America
Syken J,De-Medina T,Münger K
MA3-028 was used in Immunoprecipitation to study the mitochondrial matrix proteins encoded by TID1, and examine their opposing functions.
Tue Jul 20 00:00:00 EDT 1999
TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions.
Proceedings of the National Academy of Sciences of the United States of America
Syken J,De-Medina T,Münger K
MA3-028 was used in Immunoprecipitation to study the mitochondrial matrix proteins encoded by TID1, and examine their opposing functions.
Tue Jul 20 00:00:00 EDT 1999
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis.
The Journal of cell biology
Desagher S,Osen-Sand A,Nichols A,Eskes R,Montessuit S,Lauper S,Maundrell K,Antonsson B,Martinou JC
MA3-028 was used in immunocytochemistry and western blot to investigate the role of the Bid-induced conformational change of Bax during the mitochondrial cytochrome c release in apoptosis.
Mon Mar 08 00:00:00 EST 1999
Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis.
The Journal of cell biology
Desagher S,Osen-Sand A,Nichols A,Eskes R,Montessuit S,Lauper S,Maundrell K,Antonsson B,Martinou JC
MA3-028 was used in immunocytochemistry and western blot to investigate the role of the Bid-induced conformational change of Bax during the mitochondrial cytochrome c release in apoptosis.
Mon Mar 08 00:00:00 EST 1999
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.jpg?time=20240507?time=20240507 "mtHSP70 Antibody (MA3-028) in WB")
.jpg?time=20240507?time=20240507 "mtHSP70 Antibody (MA3-028) in WB")
