Product References
6-Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD-1 to inhibit PD-1 signalling and enhance T cell function.
Immunology
Liu L,Lei Y,Zheng Z,Zhou X,Chen S,Zeng G,Yu L,Wang P,Chen L
17-0251-82 was used in Flow Cytometry to reveal a novel anti-tumour mechanism for the drug 6-mercaptopurine (6-MP) and suggests that 6-MP warrants further clinical evaluation for other tumour types.
Sun Oct 01 00:00:00 EDT 2023
The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation.
FEBS letters
Li Y,Ruan GX,Chen W,Huang H,Zhang R,Wang J,Ouyang Y,Zhu Z,Meng L,Wang R,Huo J,Xu S,Ou X
17-0251-82 was used in Flow Cytometry to demonstrate an essential role of Wac-mediated ubH2B in PC differentiation and shed light on the epigenetic mechanisms underlying this process.
Sat Jul 01 00:00:00 EDT 2023
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Neurology(R) neuroimmunology & neuroinflammation
Gupta S,Simic M,Sagan SA,Shepherd C,Duecker J,Sobel RA,Dandekar R,Wu GF,Wu W,Pak JE,Hauser SL,Lim W,Wilson MR,Zamvil SS
17-0251-82 was used in Flow cytometry/Cell sorting to observe that anti-CD19 CAR-T cells ameliorated experimental autoimmune encephalomyelitis and thoroughly deplete B cells in peripheral tissues and in the CNS.
Wed Mar 01 00:00:00 EST 2023
Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells.
Cancer research
Chowdhury S,Kar A,Bhowmik D,Gautam A,Basak D,Sarkar I,Ghosh P,Sarkar D,Deka A,Chakraborty P,Mukhopadhyay A,Mehrotra S,Basak S,Paul S,Chatterjee S
17-0251-82 was used in Flow cytometry/Cell sorting to delineate the metabolic configuration of CD8+ T cells required for stable effector function in tumors and present an affordable approach to promote the efficacy of CD8+ T cells for adoptive T-cell therapy.
Mon Jul 18 00:00:00 EDT 2022
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Mucosal immunology
Ninnemann J,Winsauer C,Bondareva M,Kühl AA,Lozza L,Durek P,Lissner D,Siegmund B,Kaufmann SHE,Mashreghi MF,Nedospasov SA,Kruglov AA
17-0251-82 was used in Flow cytometry/Cell sorting to show how anti-TNF therapy induces mucosal healing by increasing IL-22 availability and implicates new therapeutic opportunities for IBD.
Fri Apr 01 00:00:00 EDT 2022
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.
BMC pharmacology & toxicology
Yang Y,Song S,Nie Y,Chen R,Chen P
17-0251-82 was used in Flow Cytometry to demonstrate that lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.
Tue Mar 22 00:00:00 EDT 2022
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis.
Theranostics
Yao RQ,Li ZX,Wang LX,Li YX,Zheng LY,Dong N,Wu Y,Xia ZF,Billiar TR,Ren C,Yao YM
17-0251-82 was used in Flow cytometry/Cell sorting to find a conserved and potentially targetable immunoregulatory program within DCs that associates with hyperinflammation and organ dysfunction early following sepsis induction.
Fri Jul 15 00:00:00 EDT 2022
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
Science immunology
Christian DA,Adams TA,Shallberg LA,Phan AT,Smith TE,Abraha M,Perry J,Ruthel G,Clark JT,Pritchard GH,Aronson LR,Gossa S,McGavern DB,Kedl RM,Hunter CA
17-0251-82 was used in Flow Cytometry to investigate how conventional type 1 dendritic cells (cDC1s) in the peritoneal cavity's omentum coordinate innate responses to microbial challenge and provide secondary signals required for CD8+ T cell expansion and memory formation, particularly after intraperitoneal immunization with Toxoplasma gondii.
Fri Sep 30 00:00:00 EDT 2022
Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner.
Journal of autoimmunity
Bogie JFJ,Vanmierlo T,Vanmol J,Timmermans S,Mailleux J,Nelissen K,Wijnands E,Wouters K,Stinissen P,Gustafsson JÅ,Steffensen KR,Mulder M,Zelcer N,Hendriks JJA
17-0251-82 was used in Flow cytometry/Cell sorting to show that LXRα and LXRβ have an opposite impact on immune cell function and disease severity in the experimental autoimmune encephalomyelitis model, an experimental multiple sclerosis model.
Mon Nov 01 00:00:00 EDT 2021
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Abrignani S,Addo R,Akdis M,Andrä I,Andreata F,Annunziato F,Arranz E,Bacher P,Bari S,Barnaba V,Barros-Martins J,Baumjohann D,Beccaria CG,Bernardo D,Boardman DA,Borger J,Böttcher C,Brockmann L,Burns M,Busch DH,Cameron G,Cammarata I,Cassotta A,Chang Y,Chirdo FG,Christakou E,Čičin-Šain L,Cook L,Corbett AJ,Cornelis R,Cosmi L,Davey MS,De Biasi S,De Simone G,Del Zotto G,Delacher M,Di Rosa F,Di Santo J,Diefenbach A,Dong J,Dörner T,Dress RJ,Dutertre CA,Eckle SBG,Eede P,Evrard M,Falk CS,Feuerer M,Fillatreau S,Fiz-Lopez A,Follo M,Foulds GA,Fröbel J,Gagliani N,Galletti G,Gangaev A,Garbi N,Garrote JA,Geginat J,Gherardin NA,Gibellini L,Ginhoux F,Godfrey DI,Gruarin P,Haftmann C,Hansmann L,Harpur CM,Hayday AC,Heine G,Hernández DC,Herrmann M,Hoelsken O,Huang Q,Huber S,Huber JE,Huehn J,Hundemer M,Hwang WYK,Iannacone M,Ivison SM,Jäck HM,Jani PK,Keller B,Kessler N,Ketelaars S,Knop L,Knopf J,Koay HF,Kobow K,Kriegsmann K,Kristyanto H,Krueger A,Kuehne JF,Kunze-Schumacher H,Kvistborg P,Kwok I,Latorre D,Lenz D,Levings MK,Lino AC,Liotta F,Long HM,Lugli E,MacDonald KN,Maggi L,Maini MK,Mair F,Manta C,Manz RA,Mashreghi MF,Mazzoni A,McCluskey J,Mei HE,Melchers F,Melzer S,Mielenz D,Monin L,Moretta L,Multhoff G,Muñoz LE,Muñoz-Ruiz M,Muscate F,Natalini A,Neumann K,Ng LG,Niedobitek A,Niemz J,Almeida LN,Notarbartolo S,Ostendorf L,Pallett LJ,Patel AA,Percin GI,Peruzzi G,Pinti M,Pockley AG,Pracht K,Prinz I,Pujol-Autonell I,Pulvirenti N,Quatrini L,Quinn KM,Radbruch H,Rhys H,Rodrigo MB,Romagnani C,Saggau C,Sakaguchi S,Sallusto F,Sanderink L,Sandrock I,Schauer C,Scheffold A,Scherer HU,Schiemann M,Schildberg FA,Schober K,Schoen J,Schuh W,Schüler T,Schulz AR,Schulz S,Schulze J,Simonetti S,Singh J,Sitnik KM,Stark R,Starossom S,Stehle C,Szelinski F,Tan L,Tarnok A,Tornack J,Tree TIM,van Beek JJP,van de Veen W,van Gisbergen K,Vasco C,Verheyden NA,von Borstel A,Ward-Hartstonge KA,Warnatz K,Waskow C,Wiedemann A,Wilharm A,Wing J,Wirz O,Wittner J,Yang JHM,Yang J
17-0251-82 was used in Flow cytometry/Cell sorting to provide the key aspects to consider when performing flow cytometry experiments.
Wed Dec 01 00:00:00 EST 2021
Dynamic changes in the systemic immune responses of spinal cord injury model mice.
Neural regeneration research
Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B
17-0251 was used in Flow cytometry/Cell sorting to decipher the dynamics of systemic immune responses, initiated by spinal cord injury.
Mon Feb 01 00:00:00 EST 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
17-0251-82 was used in Flow Cytometry to identify disease-relevant regulators of T cell fate by examining mutations that modify risk for multiple sclerosis.
Tue Aug 24 00:00:00 EDT 2021
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
Frontiers in immunology
Di Giorgio E,Wang L,Xiong Y,Christensen LM,Akimova T,Han R,Samanta A,Trevisanut M,Brancolini C,Beier UH,Hancock WW
17-0251-82 was used in Flow Cytometry to report that as with Mef2d, the deletion of Mef2c in Tregs switches off the expression of Il10 and Icos and leads to enhanced antitumor immunity in syngeneic models of lung cancer.
Fri Dec 17 00:00:00 EST 2021
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Frontiers in immunology
Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K
17-0251-82 was used in Flow Cytometry to enable the design of strategies to target the IDO1 and AHR pathways for enhancing anti-tumor immunity in ovarian cancer.
Fri Oct 29 00:00:00 EDT 2021
Obesity results in adipose tissue T cell exhaustion.
JCI insight
Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN
17-0251-82 was used in Flow Cytometry to assess adipose tissue T cells activation and inflammatory potential within mouse and human stromal vascular fraction.
Thu Apr 22 00:00:00 EDT 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
17-0251-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
CD80 Expression on Tumor Cells Alters Tumor Microenvironment and Efficacy of Cancer Immunotherapy by CTLA-4 Blockade.
Cancers
Vackova J,Polakova I,Johari SD,Smahel M
17-0251-82 was used in Flow Cytometry to conclude that the immunosuppressive role of tumor-cell-expressed CD80 should be considered in research into biomarkers for the prediction of cancer patients' sensitivity to immune checkpoint inhibitors and for the development of a tumor-cell-specific CD80 blockade.
Fri Apr 16 00:00:00 EDT 2021
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.
Nature immunology
Hu W,Wang ZM,Feng Y,Schizas M,Hoyos BE,van der Veeken J,Verter JG,Bou-Puerto R,Rudensky AY
17-0251-82 was used in flow cytometry to show that Treg cells are functional in settings of established broad-spectrum systemic inflammation and are capable of affording sustained reset of immune homeostasis.
Wed Sep 01 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
17-0251-82 was used in Flow Cytometry to conclude that combined hEGFR and CD25-targeted NIR-PIT is a promising treatment for hEGFR expressing cancers in which Treg cells play an immunosuppressive role.
Sat May 01 00:00:00 EDT 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
17-0251-82 was used in Flow cytometry/Cell sorting to assess the sphingosine-1-phosphate receptor modulator fingolimod as a preclinical candidate for the treatment of acute ischaemic stroke according to the Stroke Therapy Academic Industry Roundtable (STAIR) preclinical recommendations.
Tue Jun 01 00:00:00 EDT 2021
Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Zhou J,Lu Y,Wu W,Feng Y
17-0251-82 was used in Flow Cytometry to show that the restoration of Treg populations by taurine normalizes the inflammatory response, reduces AR symptomology, and reduces histopathologic signs of AR.
Sat Jun 19 00:00:00 EDT 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
17-0251-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells.
Cell metabolism
Su W,Chapman NM,Wei J,Zeng H,Dhungana Y,Shi H,Saravia J,Zhou P,Long L,Rankin S,Kc A,Vogel P,Chi H
17-0251-82 was used in Flow Cytometry to identify bidirectional metabolic signaling, specifically between immunoreceptor signaling and metabolism-mediated posttranslational lipid modifications, for the differentiation and maintenance of eTreg cells.
Tue Dec 01 00:00:00 EST 2020
MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.
The Journal of clinical investigation
Di Giorgio E,Wang L,Xiong Y,Akimova T,Christensen LM,Han R,Samanta A,Trevisanut M,Bhatti TR,Beier UH,Hancock WW
17-0251 was used in Flow cytometry/Cell sorting to study the role played by MEF2D in sustaining effector Foxp3+ Treg functions without abrogating their basal actions suggests its suitability for drug discovery efforts in cancer therapy.
Tue Dec 01 00:00:00 EST 2020
Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
The Journal of clinical investigation
Xiong Y,Wang L,Di Giorgio E,Akimova T,Beier UH,Han R,Trevisanut M,Kalin JH,Cole PA,Hancock WW
17-0251 was used in Flow cytometry/Cell sorting to analyse the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1 or Hdac2 and Lsd1 enzymes.
Wed Apr 01 00:00:00 EDT 2020
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
The Journal of experimental medicine
Oda SK,Anderson KG,Ravikumar P,Bonson P,Garcia NM,Jenkins CM,Zhuang S,Daman AW,Chiu EY,Bates BM,Greenberg PD
17-0251-82 was used in Flow Cytometry to develop enhanced adoptive T cell therapy using immunomodulatory fusion proteins for use in solid tumours.
Mon Dec 07 00:00:00 EST 2020
Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
Cancer immunology research
Huetter J,Gritzan U,Gutcher I,Doecke WD,Luetke-Eversloh MV,Golfier S,Roider HG,Frisk AL,Hunter J,Pow A,Drake A,Levine Z,Levy O,Azulay M,Barbiro I,Cojocaru G,Vaknin I,Kreft B,Roese L
17-0251 was used in Flow cytometry/Cell sorting to show that BAY 1905254 is a potential drug candidate for cancer immunotherapy.
Wed Jul 01 00:00:00 EDT 2020
Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice.
Aging cell
Runyan CE,Welch LC,Lecuona E,Shigemura M,Amarelle L,Abdala-Valencia H,Joshi N,Lu Z,Nam K,Markov NS,McQuattie-Pimentel AC,Piseaux-Aillon R,Politanska Y,Sichizya L,Watanabe S,Williams KJN,Budinger GRS,Sznajder JI,Misharin AV
17-0251 was used in Flow cytometry/Cell sorting to suggest that a loss of phagocytic function in a CX3CR1+ tissue-resident skeletal muscle macrophage population in old mice precludes satellite cell proliferation and recovery of skeletal muscle function after influenza A pneumonia.
Tue Sep 01 00:00:00 EDT 2020
Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.
Experimental and therapeutic medicine
Kang J,Feng D,Yang F,Tian X,Han W,Jia H
17-0251 was used in Flow cytometry/Cell sorting to study the therapeutic effect of rapamycin was compared with methylprednisolone (MP) on EAM.
Wed Jul 01 00:00:00 EDT 2020
Oxaliplatin-induced haematological toxicity and splenomegaly in mice.
PloS one
Lees JG,White D,Keating BA,Barkl-Luke ME,Makker PGS,Goldstein D,Moalem-Taylor G
17-0251 was used in Flow cytometry/Cell sorting to investigate oxaliplatin-induced haematological toxicities and splenomegaly in mice.
Thu Oct 29 00:00:00 EDT 2020
Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants.
Scientific reports
Wang L,Wang Z,Han R,Samanta A,Ge G,Levin LS,Levine MH,Hancock WW
17-0251 was used in Flow cytometry/Cell sorting to tested whether peri-transplant costimulation blockade could prolong VCA survival and required donor bone-marrow cells, given that bone-marrow might promote graft immunogenicity or graft-versus-host disease.
Tue Jun 09 00:00:00 EDT 2020
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Cell reports
Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that pyruvate oxidation by T cell precursors is necessary for optimal αβ T cell development.
Tue Mar 03 00:00:00 EST 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
17-0251-82 was used in Flow Cytometry to suggest that mini dendritic cell (DC) may serve as a facile and potent vaccine to boost anticancer immunotherapy.
Wed Apr 01 00:00:00 EDT 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
17-0251 was used in Flow cytometry/Cell sorting to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
17-0251 was used in Flow cytometry/Cell sorting to suggest that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.
Mon Jun 14 00:00:00 EDT 2021
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
NPJ vaccines
Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S
17-0251 was used in Flow cytometry/Cell sorting to demonstrate safe inclusion of IL-1β as an adjuvant in vaccination strategies, leading to full protection of mice against a high influenza virus challenge dose by raising potent T cell responses.
Tue Sep 19 00:00:00 EDT 2023
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Nature
Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D
17-0251-82 was used in Flow Cytometry to show drainage of gut-draining lymph nodes can resolve conflicting tolerogenic and inflammatory intestinal responses by encouraging antigen targeting to specific gut segments.
Wed May 01 00:00:00 EDT 2019
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
17-0251 was used in Flow cytometry/Cell sorting to identify two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORγt, two key transcription factors known to define innate and adaptive lymphocyte subsets.
Thu Oct 31 00:00:00 EDT 2019
Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1.
Molecular therapy oncolytics
Zhu Y,Hu X,Feng L,Yang Z,Zhou L,Duan X,Cheng S,Zhang W,Liu B,Zhang K
17-0251-82 was used in Flow Cytometry to develop a novel oncolytic herpes simplex virus 2 (HSV2) encoding an anti-human programmed cell death 1 (PD-1) monoclonal antibody (oHSV2-aPD1) and demostrate its therapeutic efficacy.
Fri Dec 20 00:00:00 EST 2019
A new role for Notch in the control of polarity and asymmetric cell division of developing T cells.
Journal of cell science
Charnley M,Ludford-Menting M,Pham K,Russell SM
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that Notch signalling controls the distribution of Notch1 itself and cell fate determinants, α-adaptin and Numb, and cooperated with CXCR4 signalling to drive polarity during T cell development.
Thu Oct 24 00:00:00 EDT 2019
Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland.
Investigative ophthalmology & visual science
Lee HK,Kim KW,Ryu JS,Jeong HJ,Lee SM,Kim MK
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that a unilateral cut of the corneal nerve results in activation of immune cells on the ocular surface and dysregulation of lacrimal secretion bilaterally through the bidirectional neuronal signals.
Wed Jan 02 00:00:00 EST 2019
Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection.
Parasite (Paris, France)
Song Y,Xu J,Wang X,Yang Y,Bai X,Pang J,Wang X,Yu M,Liu M,Liu X,Sun S
17-0251 was used in Flow cytometry/Cell sorting to examine immune cells and cytokine profiles of Trichinella spiralis infected mice by Meso Scale Discovery (MSD) and flow cytometry.
Fri May 08 00:00:00 EDT 2020
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
17-0251 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.
Nature communications
Bae J,Choi SP,Isono K,Lee JY,Park SW,Choi CY,Han J,Kim SH,Lee HH,Park K,Jin HY,Lee SJ,Park CG,Koseki H,Lee YS,Chun T
17-0251-82 was used in Flow cytometry/Cell sorting to determine the role of PHc2 in controlling the mobilisation of hematopoietic stem and progenitor cells.
Fri Aug 02 00:00:00 EDT 2019
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
17-0251 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
Modulating Shrimp Tropomyosin-Mediated Allergy: Hypoallergen DNA Vaccines Induce Regulatory T Cells to Reduce Hypersensitivity in Mouse Model.
International journal of molecular sciences
Wai CYY,Leung NYH,Leung PSC,Chu KH
17-0251-82 was used in Flow Cytometry to demonstrate the potency of hypoallergen-encoding DNA vaccines as a therapeutic strategy for human shellfish allergy via the vigorous induction of functional Treg cells.
Thu Sep 19 00:00:00 EDT 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
17-0251 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
ACS nano
Lu J,Liu X,Liao YP,Wang X,Ahmed A,Jiang W,Ji Y,Meng H,Nel AE
17-0251 was used in Flow cytometry/Cell sorting to develop a chemo-immunotherapy approach to reduce the high mortality of metastatic breast cancer, utilising a liposomal carrier to trigger immunogenic cell death.
Tue Nov 27 00:00:00 EST 2018
Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.
Frontiers in immunology
Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K
17-0251 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.
Tue Jun 25 00:00:00 EDT 2019
The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.
Frontiers in immunology
Baur J,Otto C,Steger U,Klein-Hessling S,Muhammad K,Pusch T,Murti K,Wismer R,Germer CT,Klein I,Müller N,Serfling E,Avots A
17-0251 was used in Flow cytometry/Cell sorting to show that the activity of nuclear factors of activated T cells-c1 supports the acute rejection of heterotopic heart allografts.
Wed Nov 20 00:00:00 EST 2019
Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice.
Chinese medicine
Fu YJ,Yan YQ,Qin HQ,Wu S,Shi SS,Zheng X,Wang PC,Chen XY,Tang XL,Jiang ZY
17-0251 was used in Flow cytometry/Cell sorting to show traditional chinese medicines Guizhi-and-Mahuang decoction and Yinqiao powder can provide anti-influenza functions.
Mon Mar 21 00:00:00 EDT 2022
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
17-0251 was used in Flow cytometry/Cell sorting to investigate the effects of baicalin on controlling the pulmonary infection and improving the prognosis in influenza A virus infection.
Thu Oct 01 00:00:00 EDT 2020
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells.
Cell reports
Ogawa C,Bankoti R,Nguyen T,Hassanzadeh-Kiabi N,Nadeau S,Porritt RA,Couse M,Fan X,Dhall D,Eberl G,Ohnmacht C,Martins GA
17-0251-82 was used in Flow Cytometry to study the role of Blimp-1 as a crucial regulator of the Foxp3+RORγt+ regulatory T cell subset.
Tue Oct 02 00:00:00 EDT 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
17-0251 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 EDT 2018
Experimental Combined Immunotherapy of Tumours with Major Histocompatibility Complex Class I Downregulation.
International journal of molecular sciences
Grzelak A,Polakova I,Smahelova J,Vackova J,Pekarcikova L,Tachezy R,Smahel M
17-0251 was used in Flow cytometry/Cell sorting to investigate immunotherapy in the mouse TC-1/A9 model of human papillomavirus type 16-associated tumours characterised by major histocompatibility complex class I downregulation.
Wed Nov 21 00:00:00 EST 2018
Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.
Frontiers in immunology
Cheng Y,Zhu X,Wang X,Zhuang Q,Huyan X,Sun X,Huang J,Zhan B,Zhu X
17-0251 was used in Flow cytometry/Cell sorting to introduce the first evidence that PD-1 plays a critical role in Trichinella spiralis infection-attenuated collagen-induced arthritis in a mouse model by regulating the CD4+ T cell function, which may provide the new insights into the mechanisms of helminth-induced immunomodulation of host autoimmunity.
Mon Jan 28 00:00:00 EST 2019
Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.
Arteriosclerosis, thrombosis, and vascular biology
Wang L,Wang Y,Zhang C,Li J,Meng Y,Dou M,Noguchi CT,Di L
17-0251-82 was used in Flow cytometry/Cell sorting to examine the potential mechanism by which GSK3 in modulating obesity-induced visceral adipose tissue (VAT) inflammation.
Sat Sep 01 00:00:00 EDT 2018
The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors.
Frontiers in immunology
Moreno ACR,Porchia BFMM,Pagni RL,Souza PDC,Pegoraro R,Rodrigues KB,Barros TB,Aps LRMM,de Araújo EF,Calich VLG,Ferreira LCS
17-0251 was used in Flow cytometry/Cell sorting to study the use of the combination of melatonin, a neuroimmunomodulator molecule, and an indoleamine 2,3-dioxygenase inhibitor to improve the efficacy of an immunotherapy targeting human papillomavirus.
Thu Sep 19 00:00:00 EDT 2019
Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells.
Genome biology
Koohy H,Bolland DJ,Matheson LS,Schoenfelder S,Stellato C,Dimond A,Várnai C,Chovanec P,Chessa T,Denizot J,Manzano Garcia R,Wingett SW,Freire-Pritchett P,Nagano T,Hawkins P,Stephens L,Elderkin S,Spivakov M,Fraser P,Corcoran AE,Varga-Weisz PD
17-0251 was used in Flow cytometry/Cell sorting to profile gene expression and chromatin features genome-wide, in bone marrow pro-B and pre-B cells from young and aged mice.
Wed Sep 05 00:00:00 EDT 2018
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
17-0251 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
17-0251-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 EST 2017
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
17-0251 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment.
Nature immunology
Kitagawa Y,Ohkura N,Kidani Y,Vandenbon A,Hirota K,Kawakami R,Yasuda K,Motooka D,Nakamura S,Kondo M,Taniuchi I,Kohwi-Shigematsu T,Sakaguchi S
17-0251 was used in Flow cytometry/Cell sorting to suggest that Satb1-dependent Treg cell-specific super-enhancer activation is crucial for Treg cell lineage specification in the thymus.
Wed Feb 01 00:00:00 EST 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
17-0251 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
The Journal of allergy and clinical immunology
Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM
17-0251 was used in Flow cytometry/Cell sorting to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.
Wed Feb 01 00:00:00 EST 2017
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
17-0251 was used in Flow cytometry/Cell sorting to study the endocrine regulation of conventional and regulatory T cells during reproduction.
Tue Jan 10 00:00:00 EST 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
17-0251 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells.
Frontiers in immunology
Yang WC,Hwang YS,Chen YY,Liu CL,Shen CN,Hong WH,Lo SM,Shen CR
17-0251 was used in Flow cytometry/Cell sorting to suggest the essential role of IL-4 in supporting Treg-mediated immune suppression, which may benefit the development of therapeutic strategies for autoimmune diseases.
Sun Apr 10 00:00:00 EDT 2022
In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.
PLoS pathogens
Marsden MD,Loy BA,Wu X,Ramirez CM,Schrier AJ,Murray D,Shimizu A,Ryckbosch SM,Near KE,Chun TW,Wender PA,Zack JA
17-0251 was used in Flow cytometry/Cell sorting to show that cells latently-infected by HIV exhibit both "kick" and "kill" strategies upon virus reactivation with a bryostatin 1 analogue.
Fri Sep 01 00:00:00 EDT 2017
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.
Journal of virology
Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK
17-0251 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.
Mon May 15 00:00:00 EDT 2017
Herpes Simplex Virus Glycoprotein D Targets a Specific Dendritic Cell Subset and Improves the Performance of Vaccines to Human Papillomavirus-Associated Tumors.
Molecular cancer therapeutics
Porchia BFMM,Moreno ACR,Ramos RN,Diniz MO,de Andrade LHTM,Rosa DS,Barbuto JAM,Boscardin SB,Ferreira LCS
17-0251 was used in Flow cytometry/Cell sorting to characterise a therapeutic antitumour vaccine based on the genetic fusion of the Herpes simplex virus-1 glycoprotein D with the E7 oncoprotein from human papillomavirus-16.
Fri Sep 01 00:00:00 EDT 2017
Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation.
Gene therapy
Sun Y,Peng S,Yang A,Farmer E,Wu TC,Hung CF
17-0251 was used in Flow cytometry/Cell sorting to assess the therapeutic efficacy of intravaginal immunisation with human papillomavirus pcDNA3-CRT/E7 followed by electroporation.
Sat Jul 01 00:00:00 EDT 2017
Changes in CD4+CD25+ Tregs in the pathogenesis of atherosclerosis in ApoE-/- mice.
Experimental biology and medicine (Maywood, N.J.)
Xue-Mei L,Jie C,Xuan D,Xiao-Xing L,Chun-Lin H,Yu-Jie L
17-0251 was used in Flow cytometry/Cell sorting to observe the pathological characteristics of atherosclerotic plaques in the aortic walls of ApoE-/-and C57BL/6J mice and the changes of CD4+CD25+regulatory T cells in atherosclerotic mice.
Mon May 01 00:00:00 EDT 2017
TLR2-/- Mice Display Increased Clearance of Dermatophyte Trichophyton mentagrophytes in the Setting of Hyperglycemia.
Frontiers in cellular and infection microbiology
Almeida DF,Fraga-Silva TF,Santos AR,Finato AC,Marchetti CM,Golim MA,Lara VS,Arruda MS,Venturini J
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response.
Mon Sep 18 00:00:00 EDT 2017
LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells.
Oncoimmunology
Liu H,Zhang Y,Liu Z,Wang P,Mo X,Fu W,Liu W,Cheng Y,Han W
17-0251 was used in Flow cytometry/Cell sorting to reveal a tumor-inhibiting role for LYG1 through promoting the activation, proliferation, and function of CD4+T cells in antitumor immune responses, offering implications for novel tumor immunotherapy.
Tue Jan 12 00:00:00 EST 2021
Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function.
Scientific reports
Huang J,Wang L,Dahiya S,Beier UH,Han R,Samanta A,Bergman J,Sotomayor EM,Seto E,Kozikowski AP,Hancock WW
17-0251 was used in Flow cytometry/Cell sorting to examine the effects of global histone/protein deacetylase inhibition on regulatory T cell function.
Thu Aug 17 00:00:00 EDT 2017
Culture supernatant of adipose stem cells can ameliorate allergic airway inflammation via recruitment of CD4+CD25+Foxp3 T cells.
Stem cell research & therapy
Yu HS,Park MK,Kang SA,Cho KS,Mun SJ,Roh HJ
17-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which adipose tissue stem cells (ASCs) reduce allergic symptoms and eosinophilic inflammation following injection, showing that culture supernatant of ASCs also reduced allergic airway inflammation.
Mon Jan 23 00:00:00 EST 2017
Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression.
Nature communications
Lu J,Liu X,Liao YP,Salazar F,Sun B,Jiang W,Chang CH,Jiang J,Wang X,Wu AM,Meng H,Nel AE
17-0251 was used in Flow cytometry/Cell sorting to investigate how significant tumour reduction or eradication is accomplishable by recruiting cytotoxic T lymphocytes, concomitant with down-regulation of Foxp3+ T cells.
Mon Nov 27 00:00:00 EST 2017
Respiratory Syncytial Virus Exacerbates OVA-mediated asthma in mice through C5a-C5aR regulating CD4+T cells Immune Responses.
Scientific reports
Hu X,Li X,Hu C,Qin L,He R,Luo L,Tang W,Feng J
17-0251 was used in Flow cytometry/Cell sorting to indicate that respiratory syncytial virus infection can increase C5a and C5aR expression in the pathogenesis of infected, asthmatic mice.
Thu Nov 09 00:00:00 EST 2017
Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apobtm2Sgy/Ldlrtm1Her/J mice.
Scientific reports
Thota LN,Ponnusamy T,Philip S,Lu X,Mundkur L
17-0251 was used in Flow cytometry/Cell sorting to evaluate the effect of multi-antigenic construct expressing three peptides AHC in stabilising advanced atherosclerosis in Apobtm2Sgy/Ldlrtm1Her/J mice.
Wed Jun 21 00:00:00 EDT 2017
Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.
Frontiers in cellular and infection microbiology
Wang C,Liu P,Luo J,Ding H,Gao Y,Sun L,Luo F,Liu X,He H
17-0251 was used in Flow cytometry/Cell sorting to show geldanamycin plays an important role in attenuating virus infection-induced acute lung injury/acute respiratory distress syndrome by reducing the host's inflammatory responses.
Mon Feb 26 00:00:00 EST 2018
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
17-0251 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.
The Journal of experimental medicine
Wan X,Thomas JW,Unanue ER
17-0251 was used in Flow cytometry/Cell sorting to investigate the interactions of insulin-specific T and B lymphocytes using T cell and B cell receptor transgenic mice.
Mon May 30 00:00:00 EDT 2016
Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.
Frontiers in immunology
Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE
17-0251 was used in Flow cytometry/Cell sorting to show that blocking the intrinsic apoptosis pathway with a Bcl-2/Bcl-xL inhibitor (ABT-737) caused a selective depletion of effector T cells and a relative enrichment of Tregs in vivo.
Mon Mar 14 00:00:00 EDT 2016
β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.
Mucosal immunology
Schippers A,Muschaweck M,Clahsen T,Tautorat S,Grieb L,Tenbrock K,Gaßler N,Wagner N
17-0251 was used in Flow cytometry/Cell sorting to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of inflammatory bowel disease.
Tue Mar 01 00:00:00 EST 2016
Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.
Disease models & mechanisms
Atkinson SM,Hoffmann U,Hamann A,Bach E,Danneskiold-Samsøe NB,Kristiansen K,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A
17-0251 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T cells in delayed-type hypersensitivity arthritis through depletion, and the rescuing effect of IL-7 in connection to regulatory T cell depletion.
Fri Apr 01 00:00:00 EDT 2016
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R
17-0251 was used in Flow cytometry/Cell sorting to show that small perturbations in TCR signal transduction pathways can have profound consequences on T cell differentiation and the development of autoimmune disease.
Fri Jul 15 00:00:00 EDT 2016
Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease.
Journal of hematology & oncology
Fransolet G,Ehx G,Somja J,Delens L,Hannon M,Muller J,Dubois S,Drion P,Caers J,Humblet-Baron S,Delvenne P,Beguin Y,Conteduca G,Baron F
17-0251 was used in Flow cytometry/Cell sorting to assessed the impact of azacytidine on cGVHD in a murine model of sclerodermic cGVHD.
Mon Jul 04 00:00:00 EDT 2016
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Oncoimmunology
Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL
17-0251 was used in Flow cytometry/Cell sorting to show that bone morphogenetic protein-4 causes immunosuppression by augmenting PD-L1 expression in the mesenchymal subset of lung cancer cells.
Tue Jan 12 00:00:00 EST 2021
Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads.
Bio-protocol
Alloatti A,Kotsias F,Hoffmann E,Amigorena S
17-0251 was used in Flow cytometry/Cell sorting to develop a protocol for evaluating antigen cross-presentation by dendritic cells, both in vivo and ex vivo.
Sun Nov 20 00:00:00 EST 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
17-0251-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Cell reports
Cowan JE,McCarthy NI,Anderson G
17-0251 was used in Flow cytometry/Cell sorting to investigate CCR7 and Rag2pGFP levels during Treg development, showing that CCR7 controls thymus recirculation, but not production and emigration, of Foxp3(+) T cells.
Tue Feb 09 00:00:00 EST 2016
Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.
The Journal of biological chemistry
Maganti AV,Tersey SA,Syed F,Nelson JB,Colvin SC,Maier B,Mirmira RG
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that PPAR-γ activation directly improves Β cell function and survival in non-obese diabetic mice.
Fri Oct 21 00:00:00 EDT 2016
Mycobacterium tuberculosis Induces Expansion of Foxp3 Positive CD4 T-cells with a Regulatory Profile in Tuberculin Non-sensitized Healthy Subjects: Implications for Effective Immunization against TB.
Journal of clinical & cellular immunology
Hirsch CS,Rojas R,Wu M,Toossi Z
17-0251 was used in Flow cytometry/Cell sorting to investigate the basis of iT-reg expansion in response to MTB stimulation, in the absence of prior T cell antigen responsiveness.
Wed Jun 01 00:00:00 EDT 2016
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
PloS one
Goldstein JD,Burlion A,Zaragoza B,Sendeyo K,Polansky JK,Huehn J,Piaggio E,Salomon BL,Marodon G
17-0251 was used in Flow cytometry/Cell sorting to investigate the role of the JAK/STAT pathway in controlling Foxp3 in the short term, showing dynamic regulation of Foxp3 expression.
Thu Aug 25 00:00:00 EDT 2016
HtrA2 suppresses autoimmune arthritis and regulates activation of STAT3.
Scientific reports
Lee SH,Moon YM,Seo HB,Kim SY,Kim EK,Yi J,Nam MK,Min JK,Park SH,Rhim H,Cho ML
17-0251 was used in Flow cytometry/Cell sorting to study the suppression of autoimmune arthritis and regulation of STAT3 activation via HtrA2.
Fri Dec 23 00:00:00 EST 2016
PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.
PloS one
Jones K,Ballesteros A,Mentink-Kane M,Warren J,Rattila S,Malech H,Kang E,Dveksler G
17-0251 was used in Flow cytometry/Cell sorting to investigate whether pregnancy-specific glycoprotein 9, a potential predictive biomarker of pre-eclampsia, plays an immunoregulatory role during pregnancy.
Wed Jul 26 00:00:00 EDT 2017
A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.
JCI insight
Srivastava N,Iyer S,Sudan R,Youngs C,Engelman RW,Howard KT,Russo CM,Chisholm JD,Kerr WG
17-0251 was used in Flow cytometry/Cell sorting to investigate how SHIPi represents an approach that permits control of obesity and diet-induced metabolic syndrome without apparent toxicity.
Thu Jul 21 00:00:00 EDT 2016
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.
The Journal of clinical investigation
Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW
17-0251 was used in Flow cytometry/Cell sorting to show that histone/protein deacetylase 3 is essential for the normal development and suppressive functions of thymic and peripheral FOXP3+ Tregs.
Mon Mar 02 00:00:00 EST 2015
Improved antitumor activity of immunotherapy with BRAF and MEK inhibitors in BRAF(V600E) melanoma.
Science translational medicine
Hu-Lieskovan S,Mok S,Homet Moreno B,Tsoi J,Robert L,Goedert L,Pinheiro EM,Koya RC,Graeber TG,Comin-Anduix B,Ribas A
17-0251 was used in Flow cytometry/Cell sorting to investigate the use of BRAF and MEK inhibitors with immunotherapy in patients with BRAF(V600E) melanoma.
Wed Mar 18 00:00:00 EDT 2015
T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.
Journal of the American Society of Nephrology : JASN
Noel S,Martina MN,Bandapalle S,Racusen LC,Potteti HR,Hamad AR,Reddy SP,Rabb H
17-0251 was used in Flow cytometry/Cell sorting to study how T lymphocyte-specific activation of Nrf2 protects from IR-induced AKI, and investigate the novel mechanism of tissue protection behind this.
Tue Dec 01 00:00:00 EST 2015
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NI,Cowan JE,Nakamura K,Bacon A,Baik S,White AJ,Parnell SM,Jenkinson EJ,Jenkinson WE,Anderson G
17-0251 was used in Flow cytometry/Cell sorting to elucidate the conditions controlling medullary thymic epithelial cell (mTEC) homeostasis and the production of mTEC-dependent Foxp3(+) Tregs.
Tue Sep 15 00:00:00 EDT 2015
Mucosal immunization with the live attenuated vaccine SPY1 induces humoral and Th2-Th17-regulatory T cell cellular immunity and protects against pneumococcal infection.
Infection and immunity
Xu X,Wang H,Liu Y,Wang Y,Zeng L,Wu K,Wang J,Ma F,Xu W,Yin Y,Zhang X
17-0251 was used in Flow cytometry/Cell sorting to determine the immune cell subsets that contribute to the protection conferred by the live attenuated SPY1 vaccine.
Thu Jan 01 00:00:00 EST 2015
Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.
Infection and immunity
Leroux LP,Nishi M,El-Hage S,Fox BA,Bzik DJ,Dzierszinski FS
17-0251 was used in Flow cytometry/Cell sorting to show that Toxoplasma gondii modulates the expression of key components of the MHC-II antigen presentation pathway in professional antigen-presenting cells.
Thu Oct 01 00:00:00 EDT 2015
Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.
BioMed research international
Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC
17-0251-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.
Mon Aug 01 00:00:00 EDT 2016
CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitis.
Oncotarget
Concepcion AR,Salas JT,Sáez E,Sarvide S,Ferrer A,Portu A,Uriarte I,Hervás-Stubbs S,Oude Elferink RP,Prieto J,Medina JF
17-0251 was used in Flow cytometry/Cell sorting to study the behaviour of intrahepatic T cells during different stages of life within Ae2a,b(-/-) mice.
Tue Oct 06 00:00:00 EDT 2015
Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model.
Oncotarget
Wu L,Wu MO,De la Maza L,Yun Z,Yu J,Zhao Y,Cho J,de Perrot M
17-0251 was used in Flow cytometry/Cell sorting to investigate the local and abscopal effects of targeting the CTLA-4 T cell inhibitory receptor in a murine mesothelioma model.
Wed May 20 00:00:00 EDT 2015
CD4(+)CD25(-)Foxp3(+) T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax.
Journal of translational medicine
Tang Y,Peng LP,Qin GX,Sun JT,Xu LJ,Jiang YF
17-0251 was used in Flow cytometry/Cell sorting to determine that CD4(+)CD25(-)Foxp3(+) T cells play a role in tuberculous hydrothorax rather than malignant hydrothorax.
Tue Aug 18 00:00:00 EDT 2015
Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation.
Acta pharmacologica Sinica
Baek SY,Lee J,Lee DG,Park MK,Lee J,Kwok SK,Cho ML,Park SH
17-0251 was used in Flow cytometry/Cell sorting to identify the mechanisms underlying the effects of ursolic acid on collagen-induced arthritis.
Mon Sep 01 00:00:00 EDT 2014
Protein-bound polysaccharide-K reduces the proportion of regulatory T cells in vitro and in vivo.
Oncology reports
Aoki R,Iijima H,Kato M,Uchida M,Wada T,Murata M,Ogawa K,Naritaka Y,Yoshimatsu K
17-0251 was used in Flow cytometry/Cell sorting to investigate the potential of PSK to augment antitumour immunity.
Wed Jan 01 00:00:00 EST 2014
Immune privilege of the CNS is not the consequence of limited antigen sampling.
Scientific reports
Harris MG,Hulseberg P,Ling C,Karman J,Clarkson BD,Harding JS,Zhang M,Sandor A,Christensen K,Nagy A,Sandor M,Fabry Z
17-0251 was used in Flow cytometry/Cell sorting to define the mechanisms contributing to CNS immune privilege.
Fri Mar 21 00:00:00 EDT 2014
Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.
PloS one
Nouri M,Bredberg A,Weström B,Lavasani S
17-0251 was used in Flow cytometry/Cell sorting to show that disruption of intestinal homeostasis is an early and immune-mediated event in experimental autoimmune encephalomyelitis.
Thu May 14 00:00:00 EDT 2015
Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells.
PloS one
Wang X,Qin J,Zhao RC,Zenke M
17-0251 was used in Flow cytometry/Cell sorting to compare immunogenicity of fibroblast- and sertoli cell-derived iPS cells, showing that sertoli cell-derived iPS cells have lower immunogenicity.
Tue Nov 17 00:00:00 EST 2015
Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.
PloS one
Maneva-Radicheva L,Amatya C,Parker C,Ellefson J,Radichev I,Raghavan A,Charles ML,Williams MS,Robbins MS,Savinov AY
17-0251 was used in Flow cytometry/Cell sorting to reveal that the protein, DM199, may benefit type 1 diabetics by attenuating autoimmunity and improving beta cell health.
Wed Jun 10 00:00:00 EDT 2015
Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.
Arteriosclerosis, thrombosis, and vascular biology
Ait-Oufella H,Herbin O,Lahoute C,Coatrieux C,Loyer X,Joffre J,Laurans L,Ramkhelawon B,Blanc-Brude O,Karabina S,Girard CA,Payré C,Yamamoto K,Binder CJ,Murakami M,Tedgui A,Lambeau G,Mallat Z
17-0251 was used in Flow cytometry/Cell sorting to study the proatherogenic properties of PLA2G10, a type of several secreted phospholipase A2.
Fri Mar 01 00:00:00 EST 2013
Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's disease.
Mucosal immunology
Ishikawa D,Okazawa A,Corridoni D,Jia LG,Wang XM,Guanzon M,Xin W,Arseneau KO,Pizarro TT,Cominelli F
17-0251 was used in Flow cytometry/Cell sorting to demonstrate regulatory T-cell dysfunction in a spontaneous model of Crohn's disease-like ileitis.
Fri Mar 01 00:00:00 EST 2013
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Inflammatory bowel diseases
Klimesova K,Kverka M,Zakostelska Z,Hudcovic T,Hrncir T,Stepankova R,Rossmann P,Ridl J,Kostovcik M,Mrazek J,Kopecny J,Kobayashi KS,Tlaskalova-Hogenova H
17-0251 was used in Flow cytometry/Cell sorting to compare the populations of regulatory T cells in the colons of untreated and antibiotic-treated mice with colitis-associated cancer.
Wed May 01 00:00:00 EDT 2013
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kipari T,Hadoke PW,Iqbal J,Man TY,Miller E,Coutinho AE,Zhang Z,Sullivan KM,Mitic T,Livingstone DE,Schrecker C,Samuel K,White CI,Bouhlel MA,Chinetti-Gbaguidi G,Staels B,Andrew R,Walker BR,Savill JS,Chapman KE,Seckl JR
17-0251 was used in Flow cytometry/Cell sorting to determine the effects of 11Β-Hydroxysteroid dehydrogenase type-1 deficiency on atherosclerosis and its inflammation.
Mon Apr 01 00:00:00 EDT 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that increased expression of Prdm14 drives development of T-Cell acute lymphoblastic leukemia in mice.
Fri Nov 01 00:00:00 EDT 2013
IL-17 gene ablation does not impact Treg-mediated suppression of graft-versus-host disease after bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Colonna L,Florek M,Leveson-Gower DB,Sega EI,Baker J,Smith AT,Negrin RS
17-0251 was used in Flow cytometry/Cell sorting to indicate that blocking Th17 conversion does not affect the GVHD suppressive ability of highly purified natural regulatory T-cells.
Fri Nov 01 00:00:00 EDT 2013
Parental dietary fat intake alters offspring microbiome and immunity.
Journal of immunology (Baltimore, Md. : 1950)
Myles IA,Fontecilla NM,Janelsins BM,Vithayathil PJ,Segre JA,Datta SK
17-0251 was used in Flow cytometry/Cell sorting to reveal that parental fat consumption can leave a "lard legacy", impacting offspring immunity and health.
Sun Sep 15 00:00:00 EDT 2013
Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice.
World journal of gastroenterology
Zhao HM,Huang XY,Zuo ZQ,Pan QH,Ao MY,Zhou F,Liu HN,Liu ZY,Liu DY
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that probiotics treat experimental colitis by increasing regulatory T-cell number and regulating Th1 and Th2 cytokine ratios.
Thu Feb 07 00:00:00 EST 2013
Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Dighe AS,Yang S,Madhu V,Balian G,Cui Q
17-0251 was used in Flow cytometry/Cell sorting to investigate whether MSCs can be used for bone repair, showing that interferon gamma and T cells inhibit osteogenesis induced by allogeneic MSCs.
Fri Feb 01 00:00:00 EST 2013
Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development.
The Journal of biological chemistry
Wong LY,Hatfield JK,Brown MA
17-0251 was used in Flow cytometry/Cell sorting to investigate the factors that influence the development of Th17 cells, showing that lineage gene expression is set by Ikaros.
Fri Dec 06 00:00:00 EST 2013
Analysis of the dynamics of infiltrating CD4(+) T cell subsets in the heart during experimental Trypanosoma cruzi infection.
PloS one
Sanoja C,Carbajosa S,Fresno M,Gironès N
17-0251 was used in Flow cytometry/Cell sorting to compare CD4+ T cell subsets after infection with the T. cruzi Y strain in susceptible and nonsusceptible mice.
Thu Jan 16 00:00:00 EST 2014
Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection.
PloS one
Silva-Filho JL,Souza MC,Ferreira-Dasilva CT,Silva LS,Costa MF,Padua TA,Henriques Md,Morrot A,Savino W,Caruso-Neves C,Pinheiro AA
17-0251 was used in Flow cytometry/Cell sorting to provide evidence for the potential role of Ang II in regulating the splenic immune response.
Tue Nov 26 00:00:00 EST 2013
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
17-0251 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 EST 2012
Regulatory T-cell response to apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Ait-Oufella H,Yu W,Fredrikson GN,Aubier B,Perez N,Barateau V,Nilsson J,Tedgui A,Mallat Z
17-0251 was used in Flow cytometry/Cell sorting to investigate how the induction of a specific Treg cell response to Apolipoprotein B100-derived peptides reduces the development and progression of atherosclerosis in mice.
Thu Mar 01 00:00:00 EST 2012
Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes.
Oncogene
Zaynagetdinov R,Stathopoulos GT,Sherrill TP,Cheng DS,McLoed AG,Ausborn JA,Polosukhin VV,Connelly L,Zhou W,Fingleton B,Peebles RS,Prince LS,Yull FE,Blackwell TS
17-0251 was used in Flow cytometry/Cell sorting to study whether nuclear factor kP provides an interface between persistent lung inflammation and carcinogenesis.
Thu Jun 28 00:00:00 EDT 2012
Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
The Journal of infectious diseases
Angin M,Kwon DS,Streeck H,Wen F,King M,Rezai A,Law K,Hongo TC,Pyo A,Piechocka-Trocha A,Toth I,Pereyra F,Ghebremichael M,Rodig SJ,Milner DA,Richter JM,Altfeld M,Kaufmann DE,Walker BD,Addo MM
17-0251 was used in Flow cytometry/Cell sorting to study the frequency and function of Tregs in HIV-1-infected individuals.
Tue May 15 00:00:00 EDT 2012
The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis.
Cancer immunology, immunotherapy : CII
Garrison K,Hahn T,Lee WC,Ling LE,Weinberg AD,Akporiaye ET
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that combining a TGF-β signalling inhibitor with anti-OX40 is a viable approach for treating metastatic breast cancer.
Sun Apr 01 00:00:00 EDT 2012
Cellular and cytokine-dependent immunosuppressive mechanisms of grm1-transgenic murine melanoma.
Cancer immunology, immunotherapy : CII
Alb M,Sie C,Adam C,Chen S,Becker JC,Schrama D
17-0251 was used in Flow cytometry/Cell sorting to investigate the cellular and cytokine-dependent immunosuppressive mechanisms in tumour-bearing grm1-transgenic mice.
Sat Dec 01 00:00:00 EST 2012
Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice.
Arthritis research & therapy
Xiao ZY,Chen SH,Cheng JP,Zhou WX,Zhang YX,Yang RF,Yun LH
17-0251 was used in Flow cytometry/Cell sorting to demonstrate the protective effects of Y27 against autoimmune nephritis.
Thu Nov 01 00:00:00 EDT 2012
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Martinez RJ,Zhang N,Thomas SR,Nandiwada SL,Jenkins MK,Binstadt BA,Mueller DL
17-0251 was used in Flow cytometry/Cell sorting to suggest that autoimmune arthritis develops in the setting of lymphopenia when Foxp3(+)CD4(+) regulatory T cells are insufficient to functionally inactivate all autoreactive CD4(+) T cells that encounter self-Ag.
Sun Jan 01 00:00:00 EST 2012
A critical role for Rictor in T lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P
17-0251 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.
Wed Aug 15 00:00:00 EDT 2012
Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.
The Journal of nutrition
Monk JM,Jia Q,Callaway E,Weeks B,Alaniz RC,McMurray DN,Chapkin RS
17-0251 was used in Flow cytometry/Cell sorting to test the hypothesis that (n-3) PUFA is protective against colonic inflammation during colitis.
Sun Jan 01 00:00:00 EST 2012
Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.
BMC gastroenterology
Majowicz A,van der Marel S,te Velde AA,Meijer SL,Petry H,van Deventer SJ,Ferreira V
17-0251 was used in Flow cytometry/Cell sorting to identify a new method to generate in vitro iTreg cells (TregPMA cells) with demonstrated functionality in vivo.
Mon Dec 03 00:00:00 EST 2012
MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.
PloS one
Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH
17-0251 was used in Flow cytometry/Cell sorting to investigate the role of miR-155 in the mechanisms involved in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function.
Thu Mar 28 00:00:00 EDT 2013
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.
Cell
Teijaro JR,Walsh KB,Cahalan S,Fremgen DM,Roberts E,Scott F,Martinborough E,Peach R,Oldstone MB,Rosen H
17-0251 was used in Flow cytometry/Cell sorting to elucidate cellular and signalling mechanisms that are important in initiating cytokine storm.
Fri Sep 16 00:00:00 EDT 2011
Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses.
The Journal of experimental medicine
Ohmichi Y,Hirakawa J,Imai Y,Fukuda M,Kawashima H
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that PNAd is essential for lymphocyte homing to NALT and nasal allergic responses.
Mon May 09 00:00:00 EDT 2011
Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells.
Diabetes
Muller YD,Golshayan D,Ehirchiou D,Wyss JC,Giovannoni L,Meier R,Serre-Beinier V,Puga Yung G,Morel P,Bühler LH,Seebach JD
17-0251 was used in Flow cytometry/Cell sorting to evaluate how STZ-induced diabetes affects adaptive immunity and the consequences thereof on allograft rejection.
Thu Sep 01 00:00:00 EDT 2011
A role for IL-27 in limiting T regulatory cell populations.
Journal of immunology (Baltimore, Md. : 1950)
Wojno ED,Hosken N,Stumhofer JS,O'Hara AC,Mauldin E,Fang Q,Turka LA,Levin SD,Hunter CA
17-0251 was used in Flow cytometry/Cell sorting to show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation.
Fri Jul 01 00:00:00 EDT 2011
Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Merck E,Lees RK,Voyle RB,Held W,MacDonald HR
17-0251 was used in Flow cytometry/Cell sorting to investigate the role of Ly49D-mediated ITAM signaling, showing that it impairs development by bypassing the pre-TCR checkpoint.
Fri Jul 01 00:00:00 EDT 2011
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.
Journal of immunology (Baltimore, Md. : 1950)
Hams E,McCarron MJ,Amu S,Yagita H,Azuma M,Chen L,Fallon PG
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that the coinhibitory B7-H1/programmed death 1 pathway can limit the expansion of T(FH) cells and constrain Ag-specific Ig responses.
Sun May 15 00:00:00 EDT 2011
Involvement of twisted gastrulation in T cell-independent plasma cell production.
Journal of immunology (Baltimore, Md. : 1950)
Tsalavos S,Segklia K,Passa O,Petryk A,O'Connor MB,Graf D
17-0251 was used in Flow cytometry/Cell sorting to report that Twisted gastrulation (TWSG1), is expressed in activated B cells and regulates T-independent B cell responses.
Wed Jun 15 00:00:00 EDT 2011
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
The Journal of surgical research
Brennan TV,Tang Q,Liu FC,Hoang V,Bi M,Bluestone JA,Kang SM
17-0251 was used in Flow cytometry/Cell sorting to evaluate whether Tregs with a defined allospecificity are more effective than polyclonal Tregs at suppressing allograft rejection.
Fri Jul 01 00:00:00 EDT 2011
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice.
PloS one
Ohsugi T,Kumasaka T
17-0251 was used in Flow cytometry/Cell sorting to identify the primary T-cell subsets involved in the development of arthropathy in Tax transgenic mice.
Fri Apr 01 00:00:00 EDT 2011
CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection.
PLoS neglected tropical diseases
Turner JD,Jenkins GR,Hogg KG,Aynsley SA,Paveley RA,Cook PC,Coles MC,Mountford AP
17-0251 was used in Flow cytometry/Cell sorting to suggest a role for CD4+CD25+FoxP3+ Tregs in regulating pathology of Th2 colonic granulomas during during intestinal schistosomiasis.
Mon Aug 01 00:00:00 EDT 2011
B cell depletion reduces the development of atherosclerosis in mice.
The Journal of experimental medicine
Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z
17-0251 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.
Mon Aug 02 00:00:00 EDT 2010
B cell depletion reduces the development of atherosclerosis in mice.
The Journal of experimental medicine
Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z
17-0251 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.
Mon Aug 02 00:00:00 EDT 2010
C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells.
European journal of immunology
Weaver DJ,Reis ES,Pandey MK,Köhl G,Harris N,Gerard C,Köhl J
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that C5aR signalling in DCs affects the development of immune cells.
Mon Mar 01 00:00:00 EST 2010
Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.
Cancer gene therapy
Whelan MC,Casey G,MacConmara M,Lederer JA,Soden D,Collins JK,Tangney M,O'Sullivan GC
17-0251 was used in Flow cytometry/Cell sorting to study the use of a combined immunogene therapy and regulatory T-cell inactivation against weakly immunogenic solid tumours.
Thu Jul 01 00:00:00 EDT 2010
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
17-0251 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.
Journal of molecular medicine (Berlin, Germany)
Polansky JK,Schreiber L,Thelemann C,Ludwig L,Krüger M,Baumgrass R,Cording S,Floess S,Hamann A,Huehn J
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that the methylation state of the CpG motifs within the TSDR controls its transcriptional activity rather than a Treg-specific transcription factor network.
Fri Oct 01 00:00:00 EDT 2010
Immunoregulatory properties of mouse limbal stem cells.
Journal of immunology (Baltimore, Md. : 1950)
Holan V,Pokorna K,Prochazkova J,Krulova M,Zajicova A
17-0251 was used in Flow cytometry/Cell sorting to suggest that stem cells from fresh adult limbal tissue possess immunomodulatory properties and inhibit proinflammatory immune reactions.
Mon Feb 15 00:00:00 EST 2010
Antigen aggregation decides the fate of the allergic immune response.
Journal of immunology (Baltimore, Md. : 1950)
Zaborsky N,Brunner M,Wallner M,Himly M,Karl T,Schwarzenbacher R,Ferreira F,Achatz G
17-0251 was used in Flow cytometry/Cell sorting to elucidate the molecular background of hypoallergenicity using Betula verrucosa.
Fri Jan 15 00:00:00 EST 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
17-0251 was used in Flow cytometry/Cell sorting to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Kitamura K,Farber JM,Kelsall BL
17-0251 was used in Flow cytometry/Cell sorting to conclude that CCR6 expression on Treg cells was required for the full function of Treg cell-mediated suppression in a model of colitis.
Wed Sep 15 00:00:00 EDT 2010
T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950)
Jones TG,Finkelman FD,Austen KF,Gurish MF
17-0251 was used in Flow cytometry/Cell sorting to reveal an unexpected role for T regulatory cells in antigen-induced pulmonary inflammation.
Sun Aug 01 00:00:00 EDT 2010
Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy.
Journal of immunology (Baltimore, Md. : 1950)
Rolla S,Ria F,Occhipinti S,Di Sante G,Iezzi M,Spadaro M,Nicolò C,Ambrosino E,Merighi IF,Musiani P,Forni G,Cavallo F
17-0251 was used in Flow cytometry/Cell sorting to assess the therapeutic efficacy of a combination anti-rErbb2 vaccine treatment for blocking tumour progression.
Tue Jun 01 00:00:00 EDT 2010
Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor.
Investigative ophthalmology & visual science
Zhang L,Ma J,Takeuchi M,Usui Y,Hattori T,Okunuki Y,Yamakawa N,Kezuka T,Kuroda M,Goto H
17-0251 was used in Flow cytometry/Cell sorting to examine whether the aryl hydrocarbon receptor-mediated effect of TCDD suppresses mouse experimental autoimmune uveitis, showing that it induces differentiation of Tregs.
Thu Apr 01 00:00:00 EDT 2010
IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation.
Immunology letters
Wang G,Khattar M,Guo Z,Miyahara Y,Linkes SP,Sun Z,He X,Stepkowski SM,Chen W
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that IL-2-deprivation conditions create a unique environment for efficient TGF-β-mediated suppression by Tregs.
Mon Aug 16 00:00:00 EDT 2010
Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.
Gene therapy
Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that dystrophin gene transfer induces anti-dystrophin immunity that are diminished by temporal removal of host immune cells.
Wed Sep 01 00:00:00 EDT 2010
Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.
PloS one
Muller YD,Mai G,Morel P,Serre-Beinier V,Gonelle-Gispert C,Yung GP,Ehirchiou D,Wyss JC,Bigenzahn S,Irla M,Heusser C,Golshayan D,Seebach JD,Wekerle T,Bühler LH
17-0251 was used in Flow cytometry/Cell sorting to investigate the effect of combined RAPA/MR1 treatment on rat-to-mouse islet xenograft survival, showing that it induces T regulatory cell mediated tolerance.
Mon Apr 26 00:00:00 EDT 2010
Regulatory T cells modulate postischemic neovascularization.
Circulation
Zouggari Y,Ait-Oufella H,Waeckel L,Vilar J,Loinard C,Cochain C,Récalde A,Duriez M,Levy BI,Lutgens E,Mallat Z,Silvestre JS
17-0251 was used in Flow cytometry/Cell sorting to study the role of Treg cell activation in postischemic response and vessel growth.
Tue Oct 06 00:00:00 EDT 2009
Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease.
Blood
Pillai AB,George TI,Dutt S,Strober S
17-0251 was used in Flow cytometry/Cell sorting to investigate the interactions between Tregs and NKTs following allogenic bone transplant, showing that NKTs induce IL-4-dependent expansion of Tregs that protects against graft-versus-host disease.
Thu Apr 30 00:00:00 EDT 2009
Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.
Blood
Frank MJ,Dawson DW,Bensinger SJ,Hong JS,Knosp WM,Xu L,Balatoni CE,Allen EL,Shen RR,Bar-Sagi D,Martin GR,Teitell MA
17-0251 was used in Flow cytometry/Cell sorting to determine whether epigenetic silencing of Spry2 plays a role in B-cell lymphomas.
Thu Mar 12 00:00:00 EDT 2009
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
Blood
Peng B,Ye P,Rawlings DJ,Ochs HD,Miao CH
17-0251 was used in Flow cytometry/Cell sorting to study how anti-CD3 can reduce the titers of preexisting anti-FVIII inhibitory antibodies in hemophilia A mice.
Thu Nov 12 00:00:00 EST 2009
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.
The Journal of experimental medicine
Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J
17-0251 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.
Mon Apr 13 00:00:00 EDT 2009
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
17-0251 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.
Cancer research
Du G,Jin L,Han X,Song Z,Zhang H,Liang W
17-0251 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.
Wed Apr 01 00:00:00 EDT 2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes
Parker MJ,Xue S,Alexander JJ,Wasserfall CH,Campbell-Thompson ML,Battaglia M,Gregori S,Mathews CE,Song S,Troutt M,Eisenbeis S,Williams J,Schatz DA,Haller MJ,Atkinson MA
17-0251 was used in Flow cytometry/Cell sorting to investigate the use of ATG and GCSF in therapies to reverse overt hyperglycaemia in a diabetic mouse model.
Thu Oct 01 00:00:00 EDT 2009
Lack of TNFR2 expression by CD4(+) T cells exacerbates experimental colitis.
European journal of immunology
Dayer Schneider J,Seibold I,Saxer-Sekulic N,Paredes BE,Saurer L,Mueller C
17-0251 was used in Flow cytometry/Cell sorting to assess the role of TNF receptor 2 signalling in the CD4(+) T-cell transfer model of colitis.
Wed Jul 01 00:00:00 EDT 2009
Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.
Cancer gene therapy
Boczkowski D,Lee J,Pruitt S,Nair S
17-0251 was used in Flow cytometry/Cell sorting to show significantly enhanced tumor immunity through vaccination with a combination of anti-GITR-secreting dendritic cells and tumor antigen-presenting dendritic cells, providing an effective tumor vaccine adjuvant.
Tue Dec 01 00:00:00 EST 2009
Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Li Z,Mao K,Zou J,Wang Y,Tao Z,Lin G,Tian L,Ji Y,Wu X,Zhu X,Sun S,Chen W,Xiang C,Sun B
17-0251 was used in Flow cytometry/Cell sorting to investigate the role of Dec2 in Th cell differentiation, showing that it is progressively induced at the late stage of Th2 differentiation, and that upregulation of Dec2 can promote Th2 differentiation under Th2-inducing conditions, which is due to CD25 expression elicited by Dec2.
Sun Nov 15 00:00:00 EST 2009
GITR Blockade Facilitates Treg Mediated Allograft Survival.
Transplantation
Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF
17-0251 was used in Flow cytometry/Cell sorting to study how inflammation and other innate immune signals may activate antigen presenting cells to up-regulate GITR.
Fri Nov 27 00:00:00 EST 2009
Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.
Reproduction (Cambridge, England)
Roca V,Calafat M,Larocca L,Ramhorst R,Farina M,Franchi AM,Leirós CP
17-0251 was used in Flow cytometry/Cell sorting to explore the participation of vasoactive intestinal peptide in the implantation sites of normal and pregnant prediabetic nonobese diabetic female mice.
Thu Oct 01 00:00:00 EDT 2009
Modulators of arginine metabolism support cancer immunosurveillance.
BMC immunology
Capuano G,Rigamonti N,Grioni M,Freschi M,Bellone M
17-0251 was used in Flow cytometry/Cell sorting to investigate whether N(G) nitro-L-arginine methyl ester and sildenafil, modulators of the arginine metabolism, can restore antitumor immunity.
Fri Jan 09 00:00:00 EST 2009
Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1.
Journal of immunology (Baltimore, Md. : 1950)
Rynda A,Maddaloni M,Mierzejewska D,Ochoa-Repáraz J,Maslanka T,Crist K,Riccardi C,Barszczewska B,Fujihashi K,McGhee JR,Pascual DW
17-0251 was used in Flow cytometry/Cell sorting to investigate whether targeting a model Ag to microfold cells via psigma1 could induce a state of unresponsiveness, showing that low-dose tolerance is mediated by psigma1.
Tue Apr 15 00:00:00 EDT 2008
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
17-0251 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 EST 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 EDT 2007
Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses.
Cancer research
Tuve S,Chen BM,Liu Y,Cheng TL,Touré P,Sow PS,Feng Q,Kiviat N,Strauss R,Ni S,Li ZY,Roffler SR,Lieber A
Fri Jun 15 00:00:00 EDT 2007
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Luo X,Tarbell KV,Yang H,Pothoven K,Bailey SL,Ding R,Steinman RM,Suthanthiran M
17-0251 was used in Flow cytometry/Cell sorting to reveal a role for DCs in the induction of antigen-specific CD4(+)CD25(+)Foxp3(+) T cells.
Tue Feb 20 00:00:00 EST 2007
Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis.
European journal of immunology
Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A
17-0251 was used in Flow cytometry/Cell sorting to study renal functions and autoantibody production in aged Ja281 KO mice lacking iNKT cells.
Thu Feb 01 00:00:00 EST 2007
TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets.
Journal of leukocyte biology
Pyzik M,Piccirillo CA
17-0251 was used in Flow cytometry/Cell sorting to investigate the effects of TGF-beta on the induction or maintenance of regulatory functions in different T cell subsets.
Wed Aug 01 00:00:00 EDT 2007
Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.
Cancer research
Ambrosino E,Spadaro M,Iezzi M,Curcio C,Forni G,Musiani P,Wei WZ,Cavallo F
17-0251 was used in Flow cytometry/Cell sorting to investigate role of CD4(+)CD25(+)Foxp3(+) Tregs in overcoming immunosurveillance of Erbb2 mammary lesions, showing that immunosurveillance is concealed by a dominant regulatory T-cell self-tolerance.
Tue Aug 01 00:00:00 EDT 2006
In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses.
Journal of virology
Kassim SH,Rajasagi NK,Zhao X,Chervenak R,Jennings SR
17-0251 was used in Flow cytometry/Cell sorting to investigate the role of different dendritic cell subsets in response to herpes simplex virus type 1 infection in mice.
Sat Apr 01 00:00:00 EST 2006
Inactivation of CD4+ CD25+ regulatory T cells during early mycobacterial infection increases cytokine production but does not affect pathogen load.
Immunology and cell biology
Quinn KM,McHugh RS,Rich FJ,Goldsack LM,de Lisle GW,Buddle BM,Delahunt B,Kirman JR
17-0251 was used in Flow cytometry/Cell sorting to investigate whether Mycobacterium tuberculosis exploits natural CD4+CD25+ regulatory T-cells to suppress the effector function of responding host lymphocytes.
Sun Oct 01 00:00:00 EDT 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
17-0251 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.
The Journal of experimental medicine
van Santen HM,Benoist C,Mathis D
17-0251 was used in Flow cytometry/Cell sorting to investigate whether the dose of agonist peptide/MHC ligand influences the efficiency of CD4(+)CD25(+) Treg cell generation.
Mon Nov 15 00:00:00 EST 2004
TOX provides a link between calcineurin activation and CD8 lineage commitment.
The Journal of experimental medicine
Aliahmad P,O'Flaherty E,Han P,Goularte OD,Wilkinson B,Satake M,Molkentin JD,Kaye J
17-0251 was used in Flow cytometry/Cell sorting to demonstrate that up-regulation of TOX in double positive thymocytes is calcineurin dependent, linking the signalling pathway to nuclear changes that occur during positive thymocyte selection..
Mon Apr 19 00:00:00 EDT 2004
