Product References
Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury.
Asian journal of pharmaceutical sciences
Li Y,Zhang M,Li S,Zhang L,Kim J,Qiu Q,Lu W,Wang J
14-0081-82 was used in Flow cytometry/Cell sorting to propose a combinatorial strategy by conjugating GB with highly lipophilic docosahexaenoic acid (DHA) to obtain a covalent complex GB-DHA, which can not only enhance the pharmacological effect of GB, but can also be encapsulated in liposomes stably.
Wed Mar 01 00:00:00 EST 2023
Neurogenetic identification of mosquito sensory neurons.
iScience
Konopka JK,Task D,Poinapen D,Potter CJ
14-0081-82 was used in Immunohistochemistry to introduce a valuable genetic tool for the functional analysis of Anopheles mosquito neurobiology and initiates characterization of the sensory neurons that guide mosquito behavior.
Fri May 19 00:00:00 EDT 2023
Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth.
Oncogene
Jin Y,Pan Y,Zheng S,Liu Y,Xu J,Peng Y,Zhang Z,Wang Y,Xiong Y,Xu L,Mu K,Chen S,Zheng F,Yuan Y,Fu J
14-0081-82 was used in Immunohistochemistry to investigate the role and mechanism for EGLN3-induced stabilization of Erk3.
Tue Mar 01 00:00:00 EST 2022
The gut metabolite indole-3 propionate promotes nerve regeneration and repair.
Nature
Serger E,Luengo-Gutierrez L,Chadwick JS,Kong G,Zhou L,Crawford G,Danzi MC,Myridakis A,Brandis A,Bello AT,Müller F,Sanchez-Vassopoulos A,De Virgiliis F,Liddell P,Dumas ME,Strid J,Mani S,Dodd D,Di Giovanni S
14-0081-82 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation to demonstrate the ability of a microbiome-derived metabolite, such as IPA, to facilitate regeneration and functional recovery of sensory axons through an immune-mediated mechanism.
Fri Jul 01 00:00:00 EDT 2022
Targeted gene silencing in the nervous system with CRISPR-Cas13.
Science advances
Powell JE,Lim CKW,Krishnan R,McCallister TX,Saporito-Magriña C,Zeballos MA,McPheron GD,Gaj T
14-0081-82 was used in Immunohistochemistry to demonstrate that RfxCas13d, a Cas13 ortholog with favorable characteristics to other family members, can be delivered to the mouse spinal cord and brain to silence neurodegeneration-associated genes.
Fri Jan 21 00:00:00 EST 2022
Age-induced prostaglandin E2 impairs mitochondrial fitness and increases mortality to influenza infection.
Nature communications
Chen J,Deng JC,Zemans RL,Bahmed K,Kosmider B,Zhang M,Peters-Golden M,Goldstein DR
14-0081-82 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation to identify prostaglandin E2 as a factor within the aged lung that compromise host defense to IAV by impairing the proliferation of alveolar macrophages.
Wed Nov 09 00:00:00 EST 2022
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Claes C,England WE,Danhash EP,Kiani Shabestari S,Jairaman A,Chadarevian JP,Hasselmann J,Tsai AP,Coburn MA,Sanchez J,Lim TE,Hidalgo JLS,Tu C,Cahalan MD,Lamb BT,Landreth GE,Spitale RC,Blurton-Jones M,Davtyan H
14-0081-82 was used in Immunohistochemistry to provide the first evidence that the PLCG2-P522R variant increases the capacity of microglia to recruit T cells and present antigens, promoting a microglial transcriptional state that has recently been shown to be reduced in AD patient brains.
Sat Oct 01 00:00:00 EDT 2022
Therapeutic potential of highly functional codon-optimized microutrophin for muscle-specific expression.
Scientific reports
Starikova AV,Skopenkova VV,Polikarpova AV,Reshetov DA,Vassilieva SG,Velyaev OA,Shmidt AA,Savchenko IM,Soldatov VO,Egorova TV,Bardina MV
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Mon Jan 17 00:00:00 EST 2022
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Man K,Chen Z
14-0081-82 was used in Flow Cytometry to evaluate the potential of recombinant adeno-associated virus (rAAV)-vectored, PD1-based vaccination in the tumor microenvironment (TME) to activate antigen-specific T cell responses in the immune-competent murine mesothelioma model.
Fri Mar 26 00:00:00 EDT 2021
Oncolytic Herpes Simplex Virus Type 2 Can Effectively Inhibit Colorectal Cancer Liver Metastasis by Modulating the Immune Status in the Tumor Microenvironment and Inducing Specific Antitumor Immunity.
Human gene therapy
Zhang W,Zeng B,Hu X,Zou L,Liang J,Song Y,Liu B,Liu S
14-0081 was used in Immunohistochemistry to show that oHSV2 can effectively kill the primary tumour and attack distal and metastatic tumours by inducing immune responses, resulting in lasting antitumour efficacy and preventing tumour recurrence.
Mon Feb 01 00:00:00 EST 2021
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells.
Frontiers in immunology
Di Giorgio E,Wang L,Xiong Y,Christensen LM,Akimova T,Han R,Samanta A,Trevisanut M,Brancolini C,Beier UH,Hancock WW
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Suppression of IL-23-mediated psoriasis-like inflammation by regulatory B cells.
Scientific reports
Mizumaki K,Horii M,Kano M,Komuro A,Matsushita T
14-0081-82 was used in Flow Cytometry, Immunohistochemistry to investigate the role of regulator B-cells in interleukin-23-mediated psoriasis-like inflammation in mice.
Fri Jan 22 00:00:00 EST 2021
Suppression of IL-23-mediated psoriasis-like inflammation by regulatory B cells.
Scientific reports
Mizumaki K,Horii M,Kano M,Komuro A,Matsushita T
14-0081-82 was used in Flow Cytometry, Immunohistochemistry to investigate the role of regulator B-cells in interleukin-23-mediated psoriasis-like inflammation in mice.
Fri Jan 22 00:00:00 EST 2021
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Frontiers in immunology
Wang Y,Gu T,Tian X,Li W,Zhao R,Yang W,Gao Q,Li T,Shim JH,Zhang C,Liu K,Lee MH
14-0081-82 was used in Immunohistochemistry to demonstrate that the PD-L1 inhibitor 1 can act to prevent T-cell exhaustion in immune checkpoint inhibition therapies using PD-L1.
Wed Sep 29 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction.
eLife
Ramos MIP,Tian L,de Ruiter EJ,Song C,Paucarmayta A,Singh A,Elshof E,Vijver SV,Shaik J,Bosiacki J,Cusumano Z,Jensen C,Willumsen N,Karsdal MA,Liu L,Langermann S,Willems S,Flies D,Meyaard L
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Jun 14 00:00:00 EDT 2021
MiR-146a regulates regulatory T cells to suppress heart transplant rejection in mice.
Cell death discovery
Lu J,Wang W,Li P,Wang X,Gao C,Zhang B,Du X,Liu Y,Yang Y,Qi F
14-0081-82 was used in Immunohistochemistry to investigate microRNA-146a (miR-146a), a miRNA that is widely expressed in Tregs and closely related to their homeostasis and function, with the aim of enhancing the function of Tregs by regulating miR-146a and then suppressing transplant rejection.
Thu Jun 17 00:00:00 EDT 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
14-0081-82 was used in Immunocytochemistry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 EDT 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-0081-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
The Journal of experimental medicine
Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2020
The active contribution of OPCs to neuroinflammation is mediated by LRP1.
Acta neuropathologica
Fernández-Castañeda A,Chappell MS,Rosen DA,Seki SM,Beiter RM,Johanson DM,Liskey D,Farber E,Onengut-Gumuscu S,Overall CC,Dupree JL,Gaultier A
14-0081 was used in Immunocytochemistry-Immunofluorescence to place OPCs as major regulators of neuroinflammation in an LRP1-dependent fashion.
Sat Feb 01 00:00:00 EST 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Oct 07 00:00:00 EDT 2020
Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination.
Nano letters
Son S,Nam J,Zenkov I,Ochyl LJ,Xu Y,Scheetz L,Shi J,Farokhzad OC,Moon JJ
14-0081-85 was used in Immunocytochemistry to report a new class of nanocapsules, termed sugar-capsules, entirely composed of polysaccharides derived from the microbial cell wall.
Wed Mar 11 00:00:00 EDT 2020
IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.
Arteriosclerosis, thrombosis, and vascular biology
Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J
14-0081 was used in Immunohistochemistry to demonstrate that IgE deficiency reduced atherosclerosis lesion burden, lesion lipid deposition, smooth muscle cell and endothelial cell contents, chemokine MCP (monocyte chemoattractant protein)-1 expression and macrophage accumulation.
Sun Mar 01 00:00:00 EST 2020
Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses.
Antiviral research
Matyushenko V,Kotomina T,Kudryavtsev I,Mezhenskaya D,Prokopenko P,Matushkina A,Sivak K,Muzhikyan A,Rudenko L,Isakova-Sivak I
14-0081-82 was used in Flow Cytometry to assess the induction of influenza- and respiratory syncytial virus-specific T cells in response to live attenuated influenza vaccine vector-based vaccination.
Thu Oct 01 00:00:00 EDT 2020
Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy.
Cancer immunology, immunotherapy : CII
Wachowska M,Stachura J,Tonecka K,Fidyt K,Braniewska A,Sas Z,Kotula I,Rygiel TP,Boon L,Golab J,Muchowicz A
14-0081-82 was used in Flow Cytometry to investigate the antitumor potential of photodynamic therapy combined with indoleamine 2,3-dioxygenase 1 inhibitor in the murine 4T1 and E0771 orthotopic breast cancer models.
Mon Jun 01 00:00:00 EDT 2020
CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy.
Journal of virology
Mockus TE,Netherby-Winslow CS,Atkins HM,Lauver MD,Jin G,Ren HM,Lukacher AE
14-0081-82 was used in Flow Cytometry to define biomarkers to stratify risk of progressive multifocal leukoencephalopathy and develop anti-JC polyomavirus interventions in patients suffering from progressive multifocal leukoencephalopathy.
Tue Mar 31 00:00:00 EDT 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-0081-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 EDT 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
Importance of the Immunodominant CD8+ T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection.
Infection and immunity
Gibbins MP,Müller K,Glover M,Liu J,Putrianti ED,Bauza K,Reyes-Sandoval A,Matuschewski K,Silvie O,Hafalla JCR
14-0081-82 was used in Flow Cytometry to characterise the importance of the immunodominant circumsporozoite protein-derived epitope SYIPSAEKI of Plasmodium berghei in both sporozoite- and vaccine-induced protection in murine infection models.
Fri Sep 18 00:00:00 EDT 2020
TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis.
Cancers
Chan YL,Lai WC,Chen JS,Tseng JT,Chuang PC,Jou J,Lee CT,Sun HS
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Wed Jul 08 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy.
Communications biology
Zhou L,Chen L,Hu X,Lu Y,Liu W,Sun Y,Yao T,Dong C,Shi S
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Fri Jul 03 00:00:00 EDT 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Wong YC,Huang H,Man K,Chen Z
14-0081-82 was used in Flow Cytometry to demonstrate that TWIST1, the basic helix-loop-helix transcription factor, was associated with human mesothelioma tumorigenesis and is required for the invasion and metastasis of mesothelioma in the immune-competent murine AB1 model.
Fri Mar 27 00:00:00 EDT 2020
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.
Science advances
Ma C,Yang D,Wang B,Wu C,Wu Y,Li S,Liu X,Lassen K,Dai L,Yang S
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2020
Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation.
Oncoimmunology
Lee GJ,Jun Y,Yoo HY,Jeon YK,Lee D,Lee S,Kim J
14-0081-82 was used in Immunohistochemistry (Paraffin) to to describe a murine model which expresses the human RHOA mutant gene product in a T-cell specific manner and develops AITL-like symptoms.
Wed May 13 00:00:00 EDT 2020
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
PloS one
Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Nov 16 00:00:00 EST 2020
T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis.
Nature communications
Napier RJ,Lee EJ,Davey MP,Vance EE,Furtado JM,Snow PE,Samson KA,Lashley SJ,Brown BR,Horai R,Mattapallil MJ,Xu B,Callegan MC,Uebelhoer LS,Lancioni CL,Vehe RK,Binstadt BA,Smith JR,Caspi RR,Rosenzweig HL
14-0081-82 was used in Flow Cytometry to reveal a non-conventional, T cell-intrinsic function for Nod2 in suppression of Th17 immunity and experimental uveitis.
Mon Oct 26 00:00:00 EDT 2020
In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Journal for immunotherapy of cancer
Clark PA,Sriramaneni RN,Jin WJ,Jagodinsky JC,Bates AM,Jaquish AA,Anderson BR,Le T,Lubin JA,Chakravarty I,Arthur IS,Heinze CM,Guy EI,Kler J,Klar KA,Carlson PM,Kim KM,Kuo JS,Morris ZS
14-0081 was used in Immunohistochemistry to test whether in situ vaccination inhibits the development of brain metastases in a murine melanoma model.
Wed Jul 01 00:00:00 EDT 2020
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
NPJ vaccines
Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Sep 19 00:00:00 EDT 2023
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
14-0081-82 was used in Immunohistochemistry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 EST 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0081-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-0081 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 EST 2019
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.
Blood
Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE
14-0081-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.
Thu Jul 11 00:00:00 EDT 2019
GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.
Cancer research
Salem M,Wallace C,Velegraki M,Li A,Ansa-Addo E,Metelli A,Kwon H,Riesenberg B,Wu B,Zhang Y,Guglietta S,Sun S,Liu B,Li Z
14-0081-82 was used in Flow Cytometry to demonstrate that loss of GARP in Treg cells leads to spontaneous inflammation with highly activated CD4+ and CD8+ T cells and development of enteritis.
Fri Mar 15 00:00:00 EDT 2019
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
PLoS biology
Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A
14-0081-82 was used in Flow Cytometry to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.
Fri Mar 01 00:00:00 EST 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-0081-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 EST 2019
JNK signaling coordinates with ecdysone signaling to promote pruning of Drosophila sensory neuron dendrites.
Development (Cambridge, England)
Zhu S,Chen R,Soba P,Jan YN
14-0081 was used in Immunohistochemistry to investigate the function of JNK signaling in dendrite pruning using Drosophila class IV dendritic arborization (c4da) neurons as a model.
Wed Apr 17 00:00:00 EDT 2019
Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction.
Biochimica et biophysica acta. Molecular basis of disease
Wang Y,Liu CL,Fang W,Zhang X,Yang C,Li J,Liu J,Sukhova GK,Gurish MF,Libby P,Shi GP,Zhang J
14-0081-85 was used in Immunohistochemistry (Frozen) to study the role of mouse mast cell protease-4 in cardiac dysfunction post-myocardial infarction.
Sat Jun 01 00:00:00 EDT 2019
Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.
Molecular medicine (Cambridge, Mass.)
Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Mon Jul 15 00:00:00 EDT 2019
Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.
Molecular medicine (Cambridge, Mass.)
Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Mon Jul 15 00:00:00 EDT 2019
Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8+ T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection.
Immune network
Son J,Cho YW,Woo YJ,Baek YA,Kim EJ,Cho Y,Kim JY,Kim BS,Song JJ,Ha SJ
14-0081-82 was used in Flow Cytometry to understand the level of AMP-activated protein kinase activation required for optimal memory T cell differentiation.
Mon Apr 01 00:00:00 EDT 2019
Extrinsic Acquisition of CD80 by Antigen-Specific CD8+ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection.
Immune network
Son J,Ha SJ
14-0081-82 was used in Flow Cytometry to investigate the origin and physiological role of CD80 on CD8+ T cells.
Thu Aug 01 00:00:00 EDT 2019
Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Percopo CM,Ma M,Brenner TA,Krumholz JO,Break TJ,Laky K,Rosenberg HF
14-0081 was used in Flow cytometry/Cell sorting to examine the role of the pleiotropic cytokine IL-6 in acute infection with pneumonia virus of mice.
Fri Feb 01 00:00:00 EST 2019
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Pain research & management
Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Dec 16 00:00:00 EST 2019
Hemozoin produced by mammals confers heme tolerance.
eLife
Pek RH,Yuan X,Rietzschel N,Zhang J,Jackson L,Nishibori E,Ribeiro A,Simmons W,Jagadeesh J,Sugimoto H,Alam MZ,Garrett L,Haldar M,Ralle M,Phillips JD,Bodine DM,Hamza I
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Western Blot
Tue Oct 01 00:00:00 EDT 2019
Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients.
Scientific data
Zhang Y,Zheng L,Zhang L,Hu X,Ren X,Zhang Z
14-0081-82 was used in Flow Cytometry to investigate the basic properties of tumour-infiltrating T cells (TILs) such as the functional state, migratory capability and clonal expansion.
Wed Jul 24 00:00:00 EDT 2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology
Liu C,Whitener RL,Lin A,Xu Y,Chen J,Savinov A,Leiding JW,Wallet MA,Mathews CE
14-0081-82 was used in Flow Cytometry to demonstrate that Ncf1 (p47phox) is required for activation and effector function of CD8+ T cells by acting both intrinsically within the T cell as well as within professional antigen presenting cells.
Wed Sep 09 00:00:00 EDT 2020
CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.
Theranostics
Kristensen LK,Fröhlich C,Christensen C,Melander MC,Poulsen TT,Galler GR,Lantto J,Horak ID,Kragh M,Nielsen CH,Kjaer A
14-0081 was used in Immunohistochemistry to develop radio-tracers, for detection and assessment of whole body CD4+ and CD8a+ status, in order to predict responses of tumours to an immune checkpoint inhibitor.
Fri Aug 28 00:00:00 EDT 2020
Activation of CD8⁺ T Cell Responses after Melanoma Antigen Targeting to CD169⁺ Antigen Presenting Cells in Mice and Humans.
Cancers
van Dinther D,Lopez Venegas M,Veninga H,Olesek K,Hoogterp L,Revet M,Ambrosini M,Kalay H,Stöckl J,van Kooyk Y,den Haan JMM
14-0081 was used in Flow cytometry/Cell sorting to indicate that Ab-mediated antigen targeting to CD169 is a potential strategy for the induction of melanoma-specific T cell responses in mice and in humans.
Tue Feb 05 00:00:00 EST 2019
Prim-O-glucosylcimifugin enhances the antitumour effect of PD-1 inhibition by targeting myeloid-derived suppressor cells.
Journal for immunotherapy of cancer
Gao W,Zhang X,Yang W,Dou D,Zhang H,Tang Y,Zhong W,Meng J,Bai Y,Liu Y,Yang L,Chen S,Liu H,Yang C,Sun T
14-0081-82 was used in Flow Cytometry to investigate if a potential option for enhancing the efficacy of PD-1 inhibitors in clinical applications exists.
Wed Aug 28 00:00:00 EDT 2019
90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma.
Communications biology
Hernandez R,Walker KL,Grudzinski JJ,Aluicio-Sarduy E,Patel R,Zahm CD,Pinchuk AN,Massey CF,Bitton AN,Brown RJ,Sondel PM,Morris ZS,Engle JW,Capitini CM,Weichert JP
Wed Apr 22 00:00:00 EDT 2020
Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
JCI insight
Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.
Thu Jun 20 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-0081 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-0081 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
EnanDIM - a novel family of L-nucleotide-protected TLR9 agonists for cancer immunotherapy.
Journal for immunotherapy of cancer
Kapp K,Volz B,Curran MA,Oswald D,Wittig B,Schmidt M
14-0081 was used in Immunohistochemistry to show that EnanDIM® comprise a novel family of TLR9 agonists that facilitate an efficacious activation of both innate and adaptive immunity.
Tue Jan 08 00:00:00 EST 2019
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-0081 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.
The Journal of experimental medicine
Delpoux A,Michelini RH,Verma S,Lai CY,Omilusik KD,Utzschneider DT,Redwood AJ,Goldrath AW,Benedict CA,Hedrick SM
14-0081 was used in Flow cytometry/Cell sorting to show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells.
Mon Feb 05 00:00:00 EST 2018
Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy.
Cancer research
Taylor A,Rothstein D,Rudd CE
14-0081 was used in Flow cytometry/Cell sorting to show how GSK-3 inhibitors that downregulate PD-1 expression can enhance CD8+ T-cell function in cancer therapy to a similar degree as PD-1 blocking antibodies, offering a next-generation approach in the design of immunotherapeutic approaches for cancer management.
Thu Feb 01 00:00:00 EST 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Majri SS,Fritz JM,Villarino AV,Zheng L,Kanellopoulou C,Chaigne-Delalande B,Grönholm J,Niemela JE,Afzali B,Biancalana M,Pittaluga S,Sun A,Cohen JL,Holland SM,O'Shea JJ,Uzel G,Lenardo MJ
14-0081 was used in Flow cytometry/Cell sorting to show that STAT5B, a transcription factor downstream of multiple cytokines involved in RICD, is essential for triggering apoptosis of mouse and human TEM cells, and that altered STAT5B transcriptional activity drives immunodeficiency and dysfunction.
Mon Jan 01 00:00:00 EST 2018
Inhibiting TrxR suppresses liver cancer by inducing apoptosis and eliciting potent antitumor immunity.
Oncology reports
Lei H,Wang G,Zhang J,Han Q
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.
Nature communications
Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Mar 02 00:00:00 EST 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Wed Mar 28 00:00:00 EDT 2018
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.
Scientific reports
Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Tue Feb 13 00:00:00 EST 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.
Frontiers in physiology
Lim D,Kim W,Lee C,Bae H,Kim J
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.
Cell reports
Ravussin A,Youm YH,Sander J,Ryu S,Nguyen K,Varela L,Shulman GI,Sidorov S,Horvath TL,Schultze JL,Dixit VD
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Jul 31 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Nov 08 00:00:00 EST 2018
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.
mSphere
Quach D,Collins F,Parameswaran N,McCabe L,Britton RA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses.
Frontiers in immunology
Min CK,Kim HI,Ha NY,Kim Y,Kwon EK,Yen NTH,Youn JI,Jeon YK,Inn KS,Choi MS,Cho NH
14-0081 was used in Flow cytometry/Cell sorting to show that the induction of the type I IFN/IL-10 axis by O. tsutsugamushi infection might play a significant role in the suppression of T cell responses and contribute to the short longevity of cell-mediated immunity, often observed in scrub typhus patients.
Mon Sep 30 00:00:00 EDT 2019
Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization.
Cancer research
Tan B,Shi X,Zhang J,Qin J,Zhang N,Ren H,Qian M,Siwko S,Carmon K,Liu Q,Han H,Du B,Liu M
14-0081-82 was used in Flow cytometry/Cell sorting to identify Lgr4 as a critical switch in TAMs polarization and a potentially good drug target for cancer immune therapy.
Sat Sep 01 00:00:00 EDT 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 EDT 2018
Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4⁺CD25⁺ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.
International journal of molecular sciences
Jeron A,Boehme JD,Volckmar J,Gereke M,Yevsa T,Geffers R,Guzmán CA,Schreiber J,Stegemann-Koniszewski S,Bruder D
14-0081 was used in Flow cytometry/Cell sorting to study the effects of respiratory bacterial carriage on the immune system and its implications for secondary responses.
Sat Sep 01 00:00:00 EDT 2018
Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway.
Cell reports
Chen YH,Kratchmarov R,Lin WW,Rothman NJ,Yen B,Adams WC,Nish SA,Rathmell JC,Reiner SL
14-0081 was used in Flow cytometry/Cell sorting to show that receptor-associated class I phosphatidylinositol 3-kinase (PI3K) signaling activity, indexed by phosphatidylinositol (3,4,5)-trisphosphate (PIP3) staining, is spatially restricted to the microtubule-organizing center and subsequently to one pole of the mitotic spindle in activated T and B lymphocytes.
Tue Jan 23 00:00:00 EST 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
14-0081 was used in Flow cytometry/Cell sorting to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.
Wed Sep 26 00:00:00 EDT 2018
Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.
Cancer cell
Leanza L,Romio M,Becker KA,Azzolini M,Trentin L,Managò A,Venturini E,Zaccagnino A,Mattarei A,Carraretto L,Urbani A,Kadow S,Biasutto L,Martini V,Severin F,Peruzzo R,Trimarco V,Egberts JH,Hauser C,Visentin A,Semenzato G,Kalthoff H,Zoratti M,Gulbins E,Paradisi C,Szabo I
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that specific pharmacological targeting of a mitochondrial potassium channel can lead to reactive oxygen species-mediated selective apoptosis of cancer cells in vivo, without significant side effects.
Mon Apr 10 00:00:00 EDT 2017
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.
Nature immunology
Minguet S,Kläsener K,Schaffer AM,Fiala GJ,Osteso-Ibánez T,Raute K,Navarro-Lérida I,Hartl FA,Seidl M,Reth M,Del Pozo MA
14-0081 was used in Flow cytometry/Cell sorting to study the role of Caveolin-1 in controlling the distribution of nanoclusters of isotype-specific B cell antigen receptors on the surface of B cells.
Sun Oct 01 00:00:00 EDT 2017
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-0081 was used in Immunohistochemistry to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.
The Journal of clinical investigation
Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.
The Journal of clinical investigation
Sindhava VJ,Oropallo MA,Moody K,Naradikian M,Higdon LE,Zhou L,Myles A,Green N,Nündel K,Stohl W,Schmidt AM,Cao W,Dorta-Estremera S,Kambayashi T,Marshak-Rothstein A,Cancro MP
14-0081 was used in Flow cytometry/Cell sorting to describe a relationship among the B cell receptor, TLR9, and cytokine signals that regulate B cell responses to DNA-containing antigens.
Mon May 01 00:00:00 EDT 2017
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction.
The Journal of clinical investigation
Ramjee V,Li D,Manderfield LJ,Liu F,Engleka KA,Aghajanian H,Rodell CB,Lu W,Ho V,Wang T,Li L,Singh A,Cibi DM,Burdick JA,Singh MK,Jain R,Epstein JA
14-0081 was used in Flow cytometry to suggest that epicardial Hippo signalling plays a key role in adaptive immune regulation during the post-myocardial infarction recovery phase.
Wed Mar 01 00:00:00 EST 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H
14-0081 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.
Sun Jan 01 00:00:00 EST 2017
Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA,Novack DV,Murphy TL,Murphy KM
14-0081 was used in Flow cytometry/Cell sorting to suggest that there is an unrecognized but critical role for RelB within the nonhematopoietic niche that controls normal myelopoiesis.
Tue Apr 11 00:00:00 EDT 2017
A non-canonical function of Ezh2 preserves immune homeostasis.
EMBO reports
Vasanthakumar A,Xu D,Lun AT,Kueh AJ,van Gisbergen KP,Iannarella N,Li X,Yu L,Wang D,Williams BR,Lee SC,Majewski IJ,Godfrey DI,Smyth GK,Alexander WS,Herold MJ,Kallies A,Nutt SL,Allan RS
14-0081 was used in Flow cytometry/Cell sorting to identify a chromatin-independent function of enhancer of zeste 2 that impacts on the development of the immune system.
Sat Apr 01 00:00:00 EDT 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Frontiers in immunology
Briet C,Bourdenet G,Rogner UC,Becourt C,Tardivel I,Drouot L,Arnoult C,do Rego JC,Prevot N,Massaad C,Boyer O,Boitard C
14-0081 was used in Flow cytometry/Cell sorting to characterise the ICOSL-/-NOD model.
Wed Nov 20 00:00:00 EST 2019
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-0081-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.
European journal of immunology
Mohr F,Fischer JC,Nikolaus M,Stemberger C,Dreher S,Verschoor A,Haas T,Poeck H,Busch DH
14-0081 was used in Flow cytometry/Cell sorting to demonstrate how reversible Fab multimer-based murine regulatory T cell (Treg) isolation can prevent conventional antibody label-induced interferences, and offer higher potency when applied to Treg-based therapies.
Fri Dec 01 00:00:00 EST 2017
Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.
Journal of virology
Huang CY,Yao HW,Wang LC,Shen FH,Hsu SM,Chen SH
14-0081 was used in Flow cytometry/Cell sorting to investigate the significance of viral thymidine kinase and host T cells for the persistence of Herpes simplex virus-1 in neural tissues.
Wed Feb 15 00:00:00 EST 2017
Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.
Chinese medical journal
Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sat May 20 00:00:00 EDT 2017
Immunological phenotype of the murine Lrba knockout.
Immunology and cell biology
Gámez-Díaz L,Neumann J,Jäger F,Proietti M,Felber F,Soulas-Sprauel P,Perruzza L,Grassi F,Kögl T,Aichele P,Kilimann M,Grimbacher B,Jung S
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2017
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.
Journal of immunology (Baltimore, Md. : 1950)
Leigh ND,O'Neill RE,Du W,Chen C,Qiu J,Ashwell JD,McCarthy PL,Chen GL,Cao X
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.
Sat Jul 01 00:00:00 EDT 2017
Absence of miR-182 Augments Cardiac Allograft Survival.
Transplantation
Wei L,Kaul V,Qu X,Xiong X,Lau AH,Iwai N,Martinez OM,Krams SM
14-0081 was used in Immunohistochemistry-immunofluorescence to show that miR-182 contributes to the T-cell responses to alloantigen especially under costimulation blockade.
Wed Mar 01 00:00:00 EST 2017
The inflammatory phase of fracture healing is influenced by oestrogen status in mice.
European journal of medical research
Haffner-Luntzer M,Fischer V,Prystaz K,Liedert A,Ignatius A
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Thu Jul 06 00:00:00 EDT 2017
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA biology
Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu May 04 00:00:00 EDT 2017
miR-451 limits CD4+ T cell proliferative responses to infection in mice.
Immunologic research
Chapman LM,Ture SK,Field DJ,Morrell CN
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.
Tue Aug 01 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells.
Virology
Qin Q,Lauver M,Maru S,Lin E,Lukacher AE
14-0081-82 was used in Flow Cytometry to show differentiation of protective virus-specific memory CD8 T cells in patients can be promoted by reducing viral load during persistent polyomavirus infection.
Wed Feb 01 00:00:00 EST 2017
Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.
Experimental and therapeutic medicine
Wang J,Gao ZP,Qin S,Liu CB,Zou LL
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2017
Transient Treg depletion enhances therapeutic anti-cancer vaccination.
Immunity, inflammation and disease
Fisher SA,Aston WJ,Chee J,Khong A,Cleaver AL,Solin JN,Ma S,Lesterhuis WJ,Dick I,Holt RA,Creaney J,Boon L,Robinson B,Lake RA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon May 15 00:00:00 EDT 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.
Scientific reports
Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Jan 06 00:00:00 EST 2017
Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.
Scientific reports
Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G
Mon Jan 09 00:00:00 EST 2017
Identification of inhibitors of myeloid-derived suppressor cells activity through phenotypic chemical screening.
Oncoimmunology
Schröder M,Loos S,Naumann SK,Bachran C,Krötschel M,Umansky V,Helming L,Swee LK
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Nov 16 00:00:00 EST 2017
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nature communications
Rossey I,Gilman MS,Kabeche SC,Sedeyn K,Wrapp D,Kanekiyo M,Chen M,Mas V,Spitaels J,Melero JA,Graham BS,Schepens B,McLellan JS,Saelens X
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
14-0081 was used in Flow Cytometry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.
Fri Dec 01 00:00:00 EST 2017
Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.
Stem cell research & therapy
Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ
14-0081 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.
Mon Jan 23 00:00:00 EST 2017
Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model.
Oncotarget
Rincón E,Cejalvo T,Kanojia D,Alfranca A,Rodríguez-Milla MÁ,Gil Hoyos RA,Han Y,Zhang L,Alemany R,Lesniak MS,García-Castro J
14-0081 was used in Immunohistochemistry-immunofluorescence to demonstrate the homing capacity of mouse Celyvir to CMT64 tumours.
Tue Jul 11 00:00:00 EDT 2017
C3d regulates immune checkpoint blockade and enhances antitumor immunity.
JCI insight
Platt JL,Silva I,Balin SJ,Lefferts AR,Farkash E,Ross TM,Carroll MC,Cascalho M
14-0081 was used in Immunofluorescence to investigate the mechanisms by which tumours engage T cell checkpoint regulators and expanding Tregs, showing that C3d regulates immune checkpoint blockade and enhances antitumor immunity.
Thu May 04 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-0081-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
14-0081 was used in Western Blotting to help prove the concept that subcutaneous and subconjunctival injection of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD.
Mon Feb 06 00:00:00 EST 2017
CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis.
Frontiers in cellular and infection microbiology
Suwandi A,Bargen I,Pils MC,Krey M,Zur Lage S,Singh AK,Basler T,Falk CS,Seidler U,Hornef MW,Goethe R,Weiss S
14-0081 was used in Immunohistochemistry to reveal the specific ability of MAP to aggravate intestinal inflammation and clinical symptoms.
Tue Sep 19 00:00:00 EDT 2017
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.
Nature
Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.
Nature
Verbist KC,Guy CS,Milasta S,Liedmann S,Kamiński MM,Wang R,Green DR
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Apr 21 00:00:00 EDT 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology
Xing S,Li F,Zeng Z,Zhao Y,Yu S,Shan Q,Li Y,Phillips FC,Maina PK,Qi HH,Liu C,Zhu J,Pope RM,Musselman CA,Zeng C,Peng W,Xue HH
14-0081 was used in Flow cytometry/Cell sorting to reveal that sequence-specific transcription factors can utilise intrinsic HDAC activity to guard cell identity by repressing lineage-inappropriate genes.
Wed Jun 01 00:00:00 EDT 2016
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Nature immunology
Mujal AM,Gilden JK,Gérard A,Kinoshita M,Krummel MF
14-0081 was used in Flow cytometry/Cell sorting to characterise T cells lacking the septin cytoskeleton.
Tue Mar 01 00:00:00 EST 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-0081 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 EDT 2016
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
The Journal of clinical investigation
Wang J,Mizui M,Zeng LF,Bronson R,Finnell M,Terhorst C,Kyttaris VC,Tsokos GC,Zhang ZY,Kontaridis MI
14-0081 was used in Flow cytometry/Cell sorting to explore the effect of inhibiting SHP2 on T cell activation, ERK/MAPK signalling and the production of cytokines associated with organ damage in sufferers of systemic lupus erythematosus.
Wed Jun 01 00:00:00 EDT 2016
Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation.
The Journal of clinical investigation
López-Posadas R,Becker C,Günther C,Tenzer S,Amann K,Billmeier U,Atreya R,Fiorino G,Vetrano S,Danese S,Ekici AB,Wirtz S,Thonn V,Watson AJ,Brakebusch C,Bergö M,Neurath MF,Atreya I
14-0081 was used in Immunohistochemistry to uncover deficient prenylation of Rho-A as a key player in the pathogenesis of inflammatory bowel diseases.
Mon Feb 01 00:00:00 EST 2016
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS
14-0081 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.
Tue Nov 01 00:00:00 EDT 2016
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.
The Journal of experimental medicine
Everts B,Tussiwand R,Dreesen L,Fairfax KC,Huang SC,Smith AM,O'Neill CM,Lam WY,Edelson BT,Urban JF,Murphy KM,Pearce EJ
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of CD8α+ and CD103+ dendritic cells in suppressing helminth-driven type 2 immune responses.
Mon Jan 11 00:00:00 EST 2016
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Frontiers in immunology
Akk A,Springer LE,Pham CT
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
14-0081 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 EST 2016
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.
PLoS pathogens
Maelfait J,Roose K,Vereecke L,Mc Guire C,Sze M,Schuijs MJ,Willart M,Ibañez LI,Hammad H,Lambrecht BN,Beyaert R,Saelens X,van Loo G
14-0081 was used in Flow cytometry/Cell sorting to investigate the function of A20 in club cells in antiviral immunity, showing that deficiency in A20 protects against influenza virus infection.
Fri Jan 01 00:00:00 EST 2016
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
PLoS pathogens
Kandasamy M,Suryawanshi A,Tundup S,Perez JT,Schmolke M,Manicassamy S,Manicassamy B
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid inducible gene-I in antiviral host responses.
Fri Jul 01 00:00:00 EDT 2016
Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Lo TH,Silveira PA,Fromm PD,Verma ND,Vu PA,Kupresanin F,Adam R,Kato M,Cogger VC,Clark GJ,Hart DN
14-0081 was used in Flow cytometry/Cell sorting to study CD302 expression and its potential immunological function in mouse models.
Mon Aug 01 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0081 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Transplantation
Molinero LL,Yin D,Lei YM,Chen L,Wang Y,Chong AS,Alegre ML
14-0081 was used in Flow cytometry/Cell sorting to study the mechanism by which obesity reduces the survival of organs in transplantation.
Sun May 01 00:00:00 EDT 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sun May 15 00:00:00 EDT 2016
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.
Nature communications
Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Jun 08 00:00:00 EDT 2016
Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.
BMC complementary and alternative medicine
Zhang S,Liu X,Mei L,Wang H,Fang F
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Aug 31 00:00:00 EDT 2016
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.
Scientific reports
Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Sep 13 00:00:00 EDT 2016
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.
Scientific reports
Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Sep 13 00:00:00 EDT 2016
MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury.
PloS one
Bombeiro AL,Thomé R,Oliveira Nunes SL,Monteiro Moreira B,Verinaud L,Oliveira AL
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Wed Jul 26 00:00:00 EDT 2017
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.
Nature communications
Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Oct 21 00:00:00 EDT 2016
In vitro Differentiation of Murine Innate Lymphoid Cells from Common Lymphoid Progenitor Cells.
Bio-protocol
Seehus C,Kaye J
14008182 was used in flow cytometry to detail how to obtain innate lymphoid cells from isolated common lymphoid progenitors
Sun Mar 20 00:00:00 EDT 2016
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.
PloS one
Huang B,Gomez-Rodriguez J,Preite S,Garrett LJ,Harper UL,Schwartzberg PL
14-0081 was used in Flow cytometry/Cell sorting to elucidate the contribution of the SLAM receptors in immunodysregulation observed in X-linked lymphoproliferative syndrome Type 1.
Mon Jul 24 00:00:00 EDT 2017
Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation.
Scientific reports
Hu HT,Umemori H,Hsueh YP
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunoprecipitation
Thu Sep 15 00:00:00 EDT 2016
Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation.
Scientific reports
Hu HT,Umemori H,Hsueh YP
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunoprecipitation
Thu Sep 15 00:00:00 EDT 2016
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
14-0081 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 EDT 2016
Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.
Oncoimmunology
Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB
14-0081 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.
Tue Jan 12 00:00:00 EST 2021
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
14-0081 was used in Flow cytometry/Cell sorting to investigate whether the CpG-binding protein Cxxc1 plays a role in thymocyte development.
Mon May 23 00:00:00 EDT 2016
Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.
PLoS genetics
Lomada D,Jain M,Bolner M,Reeh KA,Kang R,Reddy MC,DiGiovanni J,Richie ER
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that in addition to the NFkB pathway, Stat3-mediated signals play an essential role in regulating mTEC cellularity and medullary region homeostasis.
Fri Jan 01 00:00:00 EST 2016
Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.
eLife
Westernberg L,Conche C,Huang YH,Rigaud S,Deng Y,Siegemund S,Mukherjee S,Nosaka L,Das J,Sauer K
14-0081 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the establishment of the Notch-dependent nature of β-selection.
Thu Feb 11 00:00:00 EST 2016
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.
Nature communications
Cruz AC,Ramaswamy M,Ouyang C,Klebanoff CA,Sengupta P,Yamamoto TN,Meylan F,Thomas SK,Richoz N,Eil R,Price S,Casellas R,Rao VK,Lippincott-Schwartz J,Restifo NP,Siegel RM
14-0081 was used in Flow cytometry/Cell sorting to elucidate how palmitoylation defects in the Fas/CD95 receptor impact primary immune cells.
Fri Dec 23 00:00:00 EST 2016
Commensal-dendritic-cell interaction specifies a unique protective skin immune signature.
Nature
Naik S,Bouladoux N,Linehan JL,Han SJ,Harrison OJ,Wilhelm C,Conlan S,Himmelfarb S,Byrd AL,Deming C,Quinones M,Brenchley JM,Kong HH,Tussiwand R,Murphy KM,Merad M,Segre JA,Belkaid Y
14-0081 was used in Immunofluorescence to demonstrate that defined commensals dominantly affect skin immunity and identify the cellular mediators involved in this specification.
Thu Apr 02 00:00:00 EDT 2015
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
Nature biotechnology
Chen HJ,Sun J,Huang Z,Hou H,Arcilla M,Rakhilin N,Joe DJ,Choi J,Gadamsetty P,Milsom J,Nandakumar G,Longman R,Zhou XK,Edwards R,Chen J,Chen KY,Bu P,Wang L,Xu Y,Munroe R,Abratte C,Miller AD,Gümüş ZH,Shuler M,Nishimura N,Edelmann W,Shen X,Lipkin SM
14-0081 was used in Flow cytometry/Cell sorting to create chemokine-targeted mouse models that recapitulate the majority of common human somatic CRC mutations.
Mon Jun 01 00:00:00 EDT 2015
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2015
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance.
Cell
Steinert EM,Schenkel JM,Fraser KA,Beura LK,Manlove LS,Igyártó BZ,Southern PJ,Masopust D
14-0081 was used in Immunofluorescence to indicate that most host cells are surveyed for reinfection by segregated residents rather than by recirculating cells that migrate throughout the blood and body.
Thu May 07 00:00:00 EDT 2015
CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.
Immunity
Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW
14-0081 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cells locate virus-infected cells within tissues, showing that the CXCR3 chemokine receptor enables migration for the destruction of virus-infected cells.
Tue Mar 17 00:00:00 EDT 2015
CXCR3 chemokine receptor enables local CD8(+) T cell migration for the destruction of virus-infected cells.
Immunity
Hickman HD,Reynoso GV,Ngudiankama BF,Cush SS,Gibbs J,Bennink JR,Yewdell JW
14-0081 was used in Flow cytometry/Cell sorting to investigate how CD8(+) T cells locate virus-infected cells within tissues, showing that the CXCR3 chemokine receptor enables migration for the destruction of virus-infected cells.
Tue Mar 17 00:00:00 EDT 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-0081-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 EST 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-0081 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 EST 2015
Class-switched memory B cells remodel BCRs within secondary germinal centers.
Nature immunology
McHeyzer-Williams LJ,Milpied PJ,Okitsu SL,McHeyzer-Williams MG
14-0081 was used in Magnetic cell separation to demonstrate that vaccine boosts re-activate a cyclic germinal centre transcriptional program in class-switched memory B cells to remodel existing antibody specificities and enhance durable immunological protection.
Sun Mar 01 00:00:00 EST 2015
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.
The Journal of clinical investigation
Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-0081 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.
The Journal of experimental medicine
Omilusik KD,Best JA,Yu B,Goossens S,Weidemann A,Nguyen JV,Seuntjens E,Stryjewska A,Zweier C,Roychoudhuri R,Gattinoni L,Bird LM,Higashi Y,Kondoh H,Huylebroeck D,Haigh J,Goldrath AW
14-0081-82 was used in Flow Cytometry to study the upregulation of ZEB2 by activated T cells, specifically in the KLRG1(hi) effector CD8(+) T cell subset.
Mon Nov 16 00:00:00 EST 2015
CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages.
The Journal of experimental medicine
Kitamura T,Qian BZ,Soong D,Cassetta L,Noy R,Sugano G,Kato Y,Li J,Pollard JW
14-0081 was used in Flow cytometry/Cell sorting to report that inhibition of CC-chemokine receptor 1 may have a low toxicity, therapeutic impact in metastatic disease.
Mon Jun 29 00:00:00 EDT 2015
Injury and subsequent regeneration of muscles for activation of local innate immunity to facilitate the development and relapse of autoimmune myositis in C57BL/6 mice.
Arthritis & rheumatology (Hoboken, N.J.)
Kimura N,Hirata S,Miyasaka N,Kawahata K,Kohsaka H
14-0081 was used in Immunohistochemistry to determine whether injury and regeneration of the skeletal muscles induce an inflammatory milieu that facilitates autoimmune myositis development and relapse.
Wed Apr 01 00:00:00 EDT 2015
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Dai M,Yip YY,Hellstrom I,Hellstrom KE
14008182 was used in flow cytometry to test the efficacy of combining different monoclonal antibodies to treat cancer
Sun Mar 01 00:00:00 EST 2015
β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.
Cancer research
Hong Y,Manoharan I,Suryawanshi A,Majumdar T,Angus-Hill ML,Koni PA,Manicassamy B,Mellor AL,Munn DH,Manicassamy S
14-0081 was used in Flow cytometry/Cell sorting to show that dendritic cells in the tumour microenvironment acquire the ability to metabolise vitamin A to produce retinoic acid, driving immune tolerance.
Sun Feb 15 00:00:00 EST 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Genes & development
Miyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C
14-0081 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells.
Sun Feb 15 00:00:00 EST 2015
CD31 signals confer immune privilege to the vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Cheung K,Ma L,Wang G,Coe D,Ferro R,Falasca M,Buckley CD,Mauro C,Marelli-Berg FM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2015
CD31 signals confer immune privilege to the vascular endothelium.
Proceedings of the National Academy of Sciences of the United States of America
Cheung K,Ma L,Wang G,Coe D,Ferro R,Falasca M,Buckley CD,Mauro C,Marelli-Berg FM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
PD-1 or PD-L1 Blockade Restores Antitumor Efficacy Following SSX2 Epitope-Modified DNA Vaccine Immunization.
Cancer immunology research
Rekoske BT,Smith HA,Olson BM,Maricque BB,McNeel DG
14-0081 was used in Flow cytometry/Cell sorting to determine that vaccines aimed at eliciting effector CD8(+) T cells may have improved function when combined with PD-1 pathway inhibitors.
Sat Aug 01 00:00:00 EDT 2015
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
PLoS biology
Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ
14-0081 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
Tue Dec 01 00:00:00 EST 2015
Imaging Tolerance Induction in the Classic Medawar Neonatal Mouse Model: Active Roles of Multiple F1-Donor Cell Types.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Bascom RA,Tao KS,Tollenaar SL,West LJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunocytochemistry
Tue Sep 01 00:00:00 EDT 2015
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
EMBO reports
Walsh NC,Waters LR,Fowler JA,Lin M,Cunningham CR,Brooks DG,Rehg JE,Morse HC,Teitell MA
14-0081 was used in Flow cytometry/Cell sorting to show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers.
Mon Jun 01 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.
Oncogene
Dodd K,Nance S,Quezada M,Janke L,Morrison JB,Williams RT,Beere HM
14-0081 was used in Immunohistochemistry on frozen tissues to support a role for tumor-derived HSP70 in facilitating anti-tumor immunity to limit tumor growth.
Thu Mar 05 00:00:00 EST 2015
A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
Mucosal immunology
Dunne A,Mielke LA,Allen AC,Sutton CE,Higgs R,Cunningham CC,Higgins SC,Mills KH
14-0081 was used in Flow cytometry/Cell sorting to investigate the identification and characterisation of novel TLR2-activating lipoproteins from B. pertussis.
Fri May 01 00:00:00 EDT 2015
Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.
Mucosal immunology
Bertin S,Lozano-Ruiz B,Bachiller V,García-Martínez I,Herdman S,Zapater P,Francés R,Such J,Lee J,Raz E,González-Navajas JM
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that DUSP6 regulates CD4+ T-cell activation and differentiation by inhibiting TCR-dependent ERK1/2 activation.
Fri May 01 00:00:00 EDT 2015
Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.
Mucosal immunology
Jiang TT,Chaturvedi V,Ertelt JM,Xin L,Clark DR,Kinder JM,Way SS
14-0081 was used in Flow cytometry/Cell sorting to study susceptibility against Candida albicans fungal infectiong following eradication of commensal enteric bacteria, showing loss of commensal bacteria enhances antifungal immunity through robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, suggesting that enteric bacteria restrains activation of some immune components.
Wed Jul 01 00:00:00 EDT 2015
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine
Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A
14-0081 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.
Thu Oct 01 00:00:00 EDT 2015
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS pathogens
Napier RJ,Norris BA,Swimm A,Giver CR,Harris WA,Laval J,Napier BA,Patel G,Crump R,Peng Z,Bornmann W,Pulendran B,Buller RM,Weiss DS,Tirouvanziam R,Waller EK,Kalman D
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that potentiation of the immune response by imatinib may facilitate clearance of diverse microbial pathogens.
Sun Mar 01 00:00:00 EST 2015
Low doses of imatinib induce myelopoiesis and enhance host anti-microbial immunity.
PLoS pathogens
Napier RJ,Norris BA,Swimm A,Giver CR,Harris WA,Laval J,Napier BA,Patel G,Crump R,Peng Z,Bornmann W,Pulendran B,Buller RM,Weiss DS,Tirouvanziam R,Waller EK,Kalman D
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that potentiation of the immune response by imatinib may facilitate clearance of diverse microbial pathogens.
Sun Mar 01 00:00:00 EST 2015
IL-4 Induced Innate CD8+ T Cells Control Persistent Viral Infection.
PLoS pathogens
Lee A,Park SP,Park CH,Kang BH,Park SH,Ha SJ,Jung KC
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-4-induced innate CD8+ T cells control chronic virus infection.
Thu Oct 01 00:00:00 EDT 2015
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.
PLoS pathogens
Pascutti MF,Geerman S,Slot E,van Gisbergen KP,Boon L,Arens R,van Lier RA,Wolkers MC,Nolte MA
14-0081 was used in Flow cytometry/Cell sorting to study resolution of chronic viral infection through GITR-mediated co-stimulation enhancing CD8 T cell responses.
Sun Mar 01 00:00:00 EST 2015
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.
PLoS pathogens
Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC
14-0081 was used in Flow cytometry/Cell sorting to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.
Mon Jun 01 00:00:00 EDT 2015
Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer.
Journal of innate immunity
Rogers GL,Suzuki M,Zolotukhin I,Markusic DM,Morel LM,Lee B,Ertl HC,Herzog RW
14-0081 was used in Flow cytometry/Cell sorting to investigate the functions of TLR2, TLR9 and the downstream signalling adaptor MyD88 in antibody and CD8+ T-cell responses.
Mon Jan 25 00:00:00 EST 2016
Activated NKT cells imprint NK-cell differentiation, functionality and education.
European journal of immunology
Riese P,Trittel S,May T,Cicin-Sain L,Chambers BJ,Guzmán CA
14-0081-82 was used in Flow Cytometry to study the cellular cross-talk between natural killer T cells and natural killer cells.
Mon Jun 01 00:00:00 EDT 2015
Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models.
Molecular cancer therapeutics
Cuadrado-Castano S,Ayllon J,Mansour M,de la Iglesia-Vicente J,Jordan S,Tripathi S,García-Sastre A,Villar E
14-0081 was used in Flow cytometry/Cell sorting to demonstrate an augmented agent for cancer therapy which exploits the oncolytic properties of Newcastle disease virus.
Fri May 01 00:00:00 EDT 2015
T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue.
Journal of immunology (Baltimore, Md. : 1950)
Lebrun A,Portocarrero C,Kean RB,Barkhouse DA,Faber M,Hooper DC
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Sun Nov 01 00:00:00 EDT 2015
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Journal of immunology (Baltimore, Md. : 1950)
Sun C,Schattgen SA,Pisitkun P,Jorgensen JP,Hilterbrand AT,Wang LJ,West JA,Hansen K,Horan KA,Jakobsen MR,O'Hare P,Adler H,Sun R,Ploegh HL,Damania B,Upton JW,Fitzgerald KA,Paludan SR
14-0081 was used in Flow cytometry/Cell sorting to report that murine gammaherpesvirus 68 induces very limited innate immune responses through DNA-stimulated pathways.
Sun Feb 15 00:00:00 EST 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-0081 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
14-0081 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 EST 2015
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones DD,Wilmore JR,Allman D
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.
Sun Nov 15 00:00:00 EST 2015
Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S
14-0081-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.
Sun Mar 15 00:00:00 EDT 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-0081 was used in Functional assays to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 EDT 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-0081 was used in Functional assays to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 EDT 2015
IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Guo Y,Luan L,Rabacal W,Bohannon JK,Fensterheim BA,Hernandez A,Sherwood ER
14-0081 was used in Neutralization experiments to investigate the effect of IL-15 SA on physiologic and immunologic functions of mice.
Tue Sep 01 00:00:00 EDT 2015
A Subset of CD8αβ+ Invariant NKT Cells in a Humanized Mouse Model.
Journal of immunology (Baltimore, Md. : 1950)
Wen X,Kim S,Xiong R,Li M,Lawrenczyk A,Huang X,Chen SY,Rao P,Besra GS,Dellabona P,Casorati G,Porcelli SA,Akbari O,Exley MA,Yuan W
14-0081 was used in Blocking experiments to establish an extensively humanized mouse model phenotypically and functionally reflecting the human CD1d/iNKT TCR system.
Sat Aug 15 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45.
Human vaccines & immunotherapeutics
Vijayachari P,Vedhagiri K,Mallilankaraman K,Mathur PP,Sardesai NY,Weiner DB,Ugen KE,Muthumani K
14-0081 was used in Flow cytometry/Cell sorting to test the efficacy of a synthetic consensus DNA vaccine developed against the Leptospira membrane lipoprotein LipL45, demonstrating that this LipL45 based DNA immunogen has potential as a anti-Leptospira vaccine.
Wed May 04 00:00:00 EDT 2016
Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.
Human vaccines & immunotherapeutics
Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Mon May 16 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.
Immunobiology
Mott KR,Maazi H,Allen SJ,Zandian M,Matundan H,Ghiasi YN,Sharifi BG,Underhill D,Akbari O,Ghiasi H
14-0081 was used in Immunohistochemistry to demonstrate that Batf3-/- mice express CD8α + dendritic cells without any known infection.
Wed Apr 01 00:00:00 EDT 2015
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.
Stem cell reports
Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Tue Nov 10 00:00:00 EST 2015
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.
Stem cell reports
Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Tue Nov 10 00:00:00 EST 2015
Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries.
Oncotarget
Huang HN,Chan YL,Hui CF,Wu JL,Wu CJ,Chen JY
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunohistochemistry
Sat May 30 00:00:00 EDT 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-0081 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice.
PloS one
Khodadadi L,Cheng Q,Alexander T,Sercan-Alp Ö,Klotsche J,Radbruch A,Hiepe F,Hoyer BF,Taddeo A
14-0081 was used in Flow cytometry/Cell sorting to suggest that the effective depletion of LLPCs using bortezomib in combination with a therapy that continuously targeting B cells as their precursors may prevent the regeneration of autoreactive LLPCs.
Mon May 23 00:00:00 EDT 2016
All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β.
BMC immunology
Wang X,Wang W,Xu J,Wu S,Le Q
14-0081 was used in Flow cytometry/Cell sorting to investigate the potential effect of the application of ATRA and TGF-β on immunological tolerance and the treatment of posttransplant rejection.
Thu Mar 19 00:00:00 EDT 2015
Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.
PloS one
Bradfute SB,Anthony SM,Stuthman KS,Ayithan N,Tailor P,Shaia CI,Bray M,Ozato K,Bavari S
14-0081 was used in Functional assays to analyse the expression levels of various cytokines in the serum of mice given an Ebola virus-like particle.
Tue Feb 23 00:00:00 EST 2016
Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice.
PloS one
Honjo T,Chyu KY,Dimayuga PC,Lio WM,Yano J,Trinidad P,Zhao X,Zhou J,Cercek B,Shah PK
14-0081 was used in an ELISA assay to conclude that immunization with p210 vaccine attenuated AngII-induced hypertension and renal fibrosis.
Wed Apr 06 00:00:00 EDT 2016
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2015
Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.
mBio
Chastain EM,Getts DR,Miller SD
14-0081 was used in Flow cytometry/Cell sorting to determine that disease-susceptible SJL/J mice lacked a unique innate immune population, which plays a role in early CNS virus clearance.
Tue Aug 04 00:00:00 EDT 2015
Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.
Nature communications
Brown EM,Wlodarska M,Willing BP,Vonaesch P,Han J,Reynolds LA,Arrieta MC,Uhrig M,Scholz R,Partida O,Borchers CH,Sansonetti PJ,Finlay BB
14-0081 was used in Flow cytometry/Cell sorting to provide evidence indicating that both diet and microbes combine to contribute to the aetiology of environmental enteropathy.
Tue Aug 04 00:00:00 EDT 2015
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.
Scientific reports
Moniaga CS,Watanabe S,Honda T,Nielsen S,Hara-Chikuma M
14-0081 was used in Flow cytometry/Cell sorting to suggest that AQP9 is required for the development of sensitisation during cutaneous acquired immune responses via regulating neutrophil function.
Thu Oct 22 00:00:00 EDT 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.
PloS one
Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A
14-0081 was used in Magnetic cell separation to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.
Mon Oct 19 00:00:00 EDT 2015
Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.
Scientific reports
Casiraghi C,Márquez AC,Shanina I,Horwitz MS
14-0081 was used in Flow cytometry/Cell sorting to investigate the cause of enhanced experimental autoimmune encephalomyelitis following infection with murine γ-herpesvirus 68.
Thu Sep 10 00:00:00 EDT 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
14-0081 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 EDT 2014
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
14-0081 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 EDT 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0081 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.
The Journal of clinical investigation
Koga T,Hedrich CM,Mizui M,Yoshida N,Otomo K,Lieberman LA,Rauen T,Crispín JC,Tsokos GC
14-0081 was used in Flow cytometry/Cell sorting to investigate the factors that promote Th17-driven autoimmunity.
Thu May 01 00:00:00 EDT 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-0081 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kim TS,Cavnar MJ,Cohen NA,Sorenson EC,Greer JB,Seifert AM,Crawley MH,Green BL,Popow R,Pillarsetty N,Veach DR,Ku AT,Rossi F,Besmer P,Antonescu CR,Zeng S,Dematteo RP
14-0081 was used in Flow cytometry/Cell sorting to explore the ability of PLX3397 to deplete tumour-associated macrophages in gastrointestinal stromal cancer models.
Thu May 01 00:00:00 EDT 2014
Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Cancer research
Guéry L,Dubrot J,Lippens C,Brighouse D,Malinge P,Irla M,Pot C,Reith W,Waldburger JM,Hugues S
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of Ag-presenting CpG-activated pDCs in Th17 differentiation and antitumor immunity.
Sat Nov 15 00:00:00 EST 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
14-0081 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 EDT 2014
Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
Proceedings of the National Academy of Sciences of the United States of America
Lee WY,Sanz MJ,Wong CH,Hardy PO,Salman-Dilgimen A,Moriarty TJ,Chaconas G,Marques A,Krawetz R,Mody CH,Kubes P
14-0081 was used in Flow cytometry/Cell sorting to demonstrate a novel, critical extravascular invariant natural killer T cell-mediated mechanism of immune surveillance in joints.
Tue Sep 23 00:00:00 EDT 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-0081 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 EDT 2014
Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ
14-0081 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.
Tue Oct 14 00:00:00 EDT 2014
STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.
Cancer immunology research
Ohkuri T,Ghosh A,Kosaka A,Zhu J,Ikeura M,David M,Watkins SC,Sarkar SN,Okada H
14-0081 was used in Flow cytometry/Cell sorting to display a potential use of STING agonists for the development of effective immunotherapy.
Mon Dec 01 00:00:00 EST 2014
Gene targeting in NOD mouse embryos using zinc-finger nucleases.
Diabetes
Chen YG,Forsberg MH,Khaja S,Ciecko AE,Hessner MJ,Geurts AM
14-0081 was used in Flow cytometry/Cell sorting to investigate how to generate gene-targeted knockouts in a pure NOD background by using ZFNs without potential confounding factors introduced by contaminating genetic materials obtained from other strains.
Wed Jan 01 00:00:00 EST 2014
Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.
Diabetes
Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C
14-0081 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.
Sun Jun 01 00:00:00 EDT 2014
The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions.
Frontiers in immunology
Nandagopal N,Ali AK,Komal AK,Lee SH
14-0081 was used in Flow cytometry/Cell sorting to investigate whether the effect of IL-15 priming of NK cells can be extended to other cytokines, showing a critical role of the IL-15-PI3K-mTOR in NK effector functions.
Mon May 05 00:00:00 EDT 2014
IL-18, but not IL-12, induces production of IFN-γ in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin.
The Journal of investigative dermatology
Gosmann C,Frazer IH,Mattarollo SR,Blumenthal A
14-0081 was used in Flow cytometry/Cell sorting to show that IL-18 contributes to inducing IFN-γ in an immunosuppressive cutaneous environment caused by viral oncogene-driven hyperplasia.
Wed Oct 01 00:00:00 EDT 2014
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
PLoS pathogens
Le Saout C,Hasley RB,Imamichi H,Tcheung L,Hu Z,Luckey MA,Park JH,Durum SK,Smith M,Rupert AW,Sneller MC,Lane HC,Catalfamo M
14008182 was used in flow cytometry to investigate the effects of lymphopenia and chronic exposure to IFN on T cell homeostasis
Sat Mar 01 00:00:00 EST 2014
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
European journal of immunology
Brinkhoff B,Ostroumov D,Heemcke J,Woller N,Gürlevik E,Manns MP,Longerich T,Zender L,Harty JT,Kubicka S,Kühnel F,Wirth TC
14-0081-82 was used in Flow Cytometry to develop a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid microspheres followed by booster vaccination with Listeria monocytogenes vectors.
Tue Apr 01 00:00:00 EDT 2014
Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.
European journal of immunology
Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T
14-0081 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.
Wed Oct 01 00:00:00 EDT 2014
Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells.
Cancer immunology, immunotherapy : CII
Kosaka A,Ohkuri T,Okada H
14-0081 was used in Flow cytometry/Cell sorting to evaluate the therapeutic effects and underlying mechanisms of a combination regimen with an agonist CD40 mAb and the COX-2 inhibitor celecoxib.
Fri Aug 01 00:00:00 EDT 2014
MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2.
Journal of virology
Davies ML,Sei JJ,Siciliano NA,Xu RH,Roscoe F,Sigal LJ,Eisenlohr LC,Norbury CC
14-0081 was used in Flow cytometry/Cell sorting to investigate the ability of the innate sensing molecule Toll-like receptor 2 and the signalling molecule MyD88 to influence the innate and adaptive immune response to vaccinia virus following systemic or dermal infection.
Sat Mar 01 00:00:00 EST 2014
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.
Immunology and cell biology
Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA
14-0081 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.
Sat Nov 01 00:00:00 EDT 2014
Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.
Immunology and cell biology
Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that T-cell colitogenicity is achieved through multiple processes, offering a therapeutic rationale by intervening these pathways.
Wed Jan 01 00:00:00 EST 2014
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunology and cell biology
Zvezdova E,Lee J,El-Khoury D,Barr V,Akpan I,Samelson L,Love PE
14-0081 was used in Flow cytometry/Cell sorting to investigate the functional importance of different Themis1 domains.
Mon Sep 01 00:00:00 EDT 2014
Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ
14-0081 was used in Flow cytometry/Cell sorting to define the expression profile, scavenging activity, and ligand specificity of CCL2 receptors on mouse leukocytes.
Tue Jul 01 00:00:00 EDT 2014
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
Journal of immunology (Baltimore, Md. : 1950)
Duong S,Condotta SA,Rai D,Martin MD,Griffith TS,Badovinac VP
14-0081 was used in Flow cytometry/Cell sorting to study the role of sepsis in shaping the quantity and functionality of infection- or vaccine-induced memory CD8 T cells.
Tue Apr 15 00:00:00 EDT 2014
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.
Sat Mar 15 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-0081-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K
14-0081 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.
Sat Mar 01 00:00:00 EST 2014
Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors.
Journal of immunology (Baltimore, Md. : 1950)
Chernova I,Jones DD,Wilmore JR,Bortnick A,Yucel M,Hershberg U,Allman D
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of subpopulations of bone marrow plasma cells in long-term humoral responses to T cell-dependent Ag.
Sat Nov 15 00:00:00 EST 2014
Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Saunders AE,Shim YA,Johnson P
14-0081 was used in Flow cytometry/Cell sorting to demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation.
Mon Sep 15 00:00:00 EDT 2014
IFNαR signaling in effector but not regulatory T cells is required for immune dysregulation during type I IFN-dependent inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950)
Srivastava S,Koch LK,Campbell DJ
14-0081 was used in Flow cytometry/Cell sorting to study how chronic IFN expression can drive inflammatory disease via its direct effects on effector, but not regulatory, T cells.
Mon Sep 15 00:00:00 EDT 2014
B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lamagna C,Hu Y,DeFranco AL,Lowell CA
14-0081-82 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.
Sat Feb 01 00:00:00 EST 2014
Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.
Journal of immunology (Baltimore, Md. : 1950)
Nagaoka M,Hatta Y,Kawaoka Y,Malherbe LP
14-0081 was used in Flow cytometry/Cell sorting to compare CD4 T cell responses induced by peptides displaying varying binding half-lives with MHC class II before and after influenza virus infection.
Mon Sep 15 00:00:00 EDT 2014
Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii.
International journal for parasitology
Patil V,Zhao Y,Shah S,Fox BA,Rommereim LM,Bzik DJ,Yap GS
14-0081 was used in Flow cytometry/Cell sorting to highlight the multi-functionality of macrophages as they respond to diverse microbial and endogenous stimuli.
Sat Feb 01 00:00:00 EST 2014
KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.
Autoimmunity
Koga T,Mizui M,Yoshida N,Otomo K,Lieberman LA,Crispín JC,Tsokos GC
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism of CaMK4 on Treg cells in systemic lupus erythematosus, showing that inhibition promotes generation and function of Foxp3+ Tregs.
Sat Nov 01 00:00:00 EDT 2014
Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice.
PloS one
Rauen J,Kreer C,Paillard A,van Duikeren S,Benckhuijsen WE,Camps MG,Valentijn AR,Ossendorp F,Drijfhout JW,Arens R,Burgdorf S
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that mannosylation of synthetic long peptides augments the induction of a cytotoxic T-cell response.
Mon Oct 26 00:00:00 EDT 2015
Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.
Journal of inflammation research
Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC
14-0081 was used in Flow cytometry/Cell sorting to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.
Thu Mar 27 00:00:00 EDT 2014
Systemic and mucosal immune reactivity upon Mycobacterium avium ssp. paratuberculosis infection in mice.
PloS one
Koc A,Bargen I,Suwandi A,Roderfeld M,Tschuschner A,Rath T,Gerlach GF,Hornef M,Goethe R,Weiss S,Roeb E
14-0081 was used in Flow cytometry/Cell sorting to study immune responses to Mycobacterium avium ssp. paratuberculosis infection to assess a link to the development of Crohn's disease.
Fri May 29 00:00:00 EDT 2015
A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome.
Acta neuropathologica communications
Yang M,Rainone A,Shi XQ,Fournier S,Zhang J
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Jan 08 00:00:00 EST 2014
Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy.
Molecular cancer
Chang LS,Leng CH,Yeh YC,Wu CC,Chen HW,Huang HM,Liu SJ
14-0081 was used in Functional assays to assess the anti-tumour efficacy of a combination therapy of TLR9 agonist and rlipo-E7m.
Wed Mar 19 00:00:00 EDT 2014
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
PloS one
Geherin SA,Wilson RP,Jennrich S,Debes GF
14-0081 was used in Flow cytometry/Cell sorting to assess the role of CXCR4 for T cell egress from chronically inflamed skin.
Wed Jan 14 00:00:00 EST 2015
A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.
PloS one
Leigh ND,Bian G,Ding X,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X
14-0081 was used in Flow cytometry/Cell sorting to assess the immunogenic capabilities of CBLB502, a toll-like receptor 5 agonist.
Wed Sep 17 00:00:00 EDT 2014
The use of anchored agonists of phagocytic receptors for cancer immunotherapy: B16-F10 murine melanoma model.
PloS one
Janotová T,Jalovecká M,Auerová M,Švecová I,Bruzlová P,Maierová V,Kumžáková Z,Cunátová Š,Vlčková Z,Caisová V,Rozsypalová P,Lukáčová K,Vácová N,Wachtlová M,Salát J,Lieskovská J,Kopecký J,Ženka J
14-0081 was used in Flow cytometry/Cell sorting to assess the anti-tumour potential of fusing phagocytic receptor agonists to cancer cells.
Thu Sep 18 00:00:00 EDT 2014
The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus.
PloS one
Costes LM,van der Vliet J,Farro G,Matteoli G,van Bree SH,Olivier BJ,Nolte MA,Boeckxstaens GE,Cailotto C
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that intestinal manipulation results in two distinct phenomena: local intestinal inflammation and a decrease in splenic cellularity.
Fri Nov 06 00:00:00 EST 2015
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-0081 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 EDT 2015
CD8α dendritic cells drive establishment of HSV-1 latency.
PloS one
Mott KR,Allen SJ,Zandian M,Konda B,Sharifi BG,Jones C,Wechsler SL,Town T,Ghiasi H
14-0081 was used in Immunohistochemistry to investigate the impact of CD8α dendritic cells on HSV-1 latency in mice.
Tue Jan 20 00:00:00 EST 2015
Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis.
The Journal of biological chemistry
Bhattacharya A,Parillon X,Zeng S,Han S,Eissa NT
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Sep 19 00:00:00 EDT 2014
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-0081 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-0081 was used in Immunocytochemistry to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 EST 2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-0081 was used in Immunocytochemistry to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 EST 2013
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.
Immunity
Mandl JN,Monteiro JP,Vrisekoop N,Germain RN
14-0081 was used in Flow cytometry/Cell sorting to provide evidence for a connection between thymic recognition events and foreign antigen-driven T cell responses.
Thu Feb 21 00:00:00 EST 2013
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Cell host & microbe
Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW
14-0081 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.
Wed Feb 13 00:00:00 EST 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Nature immunology
Keating R,Hertz T,Wehenkel M,Harris TL,Edwards BA,McClaren JL,Brown SA,Surman S,Wilson ZS,Bradley P,Hurwitz J,Chi H,Doherty PC,Thomas PG,McGargill MA
14-0081 was used in Flow cytometry/Cell sorting to investigate the immunological mechanisms that promote heterosubtypic immunity, showing that mTOR modulates the antibody response to provide cross-protective immunity to lethal infection.
Sun Dec 01 00:00:00 EST 2013
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Nature immunology
Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ
14-0081 was used in Flow cytometry/Cell sorting to provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation.
Wed May 01 00:00:00 EDT 2013
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Nature immunology
Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB
14-0081 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.
Tue Jan 01 00:00:00 EST 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-0081 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-0081-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 EDT 2013
Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
Blood
Nijagal A,Derderian C,Le T,Jarvis E,Nguyen L,Tang Q,Mackenzie TC
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms of antigen presentation that induce a tolerant post-transplant immune response.
Thu May 30 00:00:00 EDT 2013
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
The Journal of clinical investigation
Huber M,Heink S,Pagenstecher A,Reinhard K,Ritter J,Visekruna A,Guralnik A,Bollig N,Jeltsch K,Heinemann C,Wittmann E,Buch T,Prazeres da Costa O,Brüstle A,Brenner D,Mak TW,Mittrücker HW,Tackenberg B,Kamradt T,Lohoff M
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of IL-17-producing CD8+ T cells in multiple sclerosis using a murine model.
Tue Jan 01 00:00:00 EST 2013
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.
The Journal of clinical investigation
Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM
14-0081 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.
Sun Dec 01 00:00:00 EST 2013
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.
Kidney international
Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X
14-0081 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.
Sun Sep 01 00:00:00 EDT 2013
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
The Journal of experimental medicine
Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N
14-0081 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.
Mon Nov 18 00:00:00 EST 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-0081 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 EST 2013
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.
The Journal of experimental medicine
Mielke LA,Jones SA,Raverdeau M,Higgs R,Stefanska A,Groom JR,Misiak A,Dungan LS,Sutton CE,Streubel G,Bracken AP,Mills KH
14-0081 was used in Flow cytometry/Cell sorting to provide novel insights into the molecular events controlling IL-22 transcription.
Mon Jun 03 00:00:00 EDT 2013
Antigen-coated poly α-hydroxy acid based microparticles for heterologous prime-boost adenovirus based vaccinations.
Biomaterials
Lemke CD,Geary SM,Joshi VB,Salem AK
14-0081 was used in Flow cytometry/Cell sorting to provide support for using poly α-hydroxy acid-based microparticles in prime-boost viral vaccination strategies geared toward the safer, and potentially more efficient, generation of anti-tumor immunity.
Fri Mar 01 00:00:00 EST 2013
Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.
EMBO molecular medicine
Kollmann K,Pestka JM,Kühn SC,Schöne E,Schweizer M,Karkmann K,Otomo T,Catala-Lehnen P,Failla AV,Marshall RP,Krause M,Santer R,Amling M,Braulke T,Schinke T
14-0081 was used in Flow cytometry/Cell sorting to analyse the impact of GlcNAc-1-phosphotransferase deficiency on skeletal alterations in a mouse model of mucolipidosis type II.
Sun Dec 01 00:00:00 EST 2013
Dose-dense chemotherapy improves mechanisms of antitumor immune response.
Cancer research
Chang CL,Hsu YT,Wu CC,Lai YZ,Wang C,Yang YC,Wu TC,Hung CF
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Generation of hypoallergenic neoglycoconjugates for dendritic cell targeted vaccination: a novel tool for specific immunotherapy.
Journal of controlled release : official journal of the Controlled Release Society
Weinberger EE,Himly M,Myschik J,Hauser M,Altmann F,Isakovic A,Scheiblhofer S,Thalhamer J,Weiss R
14-0081 was used in Flow cytometry/Cell sorting to investigate carbohydrate-mediated targeting of allergens to dermal antigen-presenting cells and its influence on immunogenicity and allergenicity.
Mon Jan 28 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
14-0081 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.
Journal of immunology (Baltimore, Md. : 1950)
Kearl TJ,Jing W,Gershan JA,Johnson BD
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that a blockade of the PD-1/PD-L1 pathway yields positive antitumour results.
Sat Jun 01 00:00:00 EDT 2013
Temporal requirements for B cells in the establishment of CD4 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Mollo SB,Zajac AJ,Harrington LE
14-0081 was used in Flow cytometry/Cell sorting to demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses.
Sun Dec 15 00:00:00 EST 2013
Peripheral tissue homing receptors enable T cell entry into lymph nodes and affect the anatomical distribution of memory cells.
Journal of immunology (Baltimore, Md. : 1950)
Brinkman CC,Rouhani SJ,Srinivasan N,Engelhard VH
14-0081 was used in Flow cytometry/Cell sorting to characterise the expression of different cell surface markers on T cells present within different regions of lymph nodes.
Sun Sep 01 00:00:00 EDT 2013
An alternative role for Foxp3 as an effector T cell regulator controlled through CD40.
Journal of immunology (Baltimore, Md. : 1950)
Vaitaitis GM,Carter JR,Waid DM,Olmstead MH,Wagner DH
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of CD40 in pathogenic T cell development in diabetes.
Mon Jul 15 00:00:00 EDT 2013
Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Stolp J,Mariño E,Batten M,Sierro F,Cox SL,Grey ST,Silveira PA
14-0081 was used in Flow cytometry/Cell sorting to investigate the underlying causes of augmented marginal zone B cell production in NOD mice.
Mon Jul 01 00:00:00 EDT 2013
Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Wu C,Song J,Götte M,Sorokin L
14-0081 was used in Flow cytometry/Cell sorting to investigate how the choroid plexus epithelium is a novel source of IL-6 in EAE and demonstrate that its expression negatively correlates with syndecan-1 expression at this site.
Fri Nov 01 00:00:00 EDT 2013
The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SY,Goverman JM
14-0081 was used in Flow cytometry/Cell sorting to analyse the role of Tim-3 signalling within various innate immune cells on the development of experimental autoimmune encephalomyelitis.
Wed May 15 00:00:00 EDT 2013
Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950)
He LZ,Prostak N,Thomas LJ,Vitale L,Weidlick J,Crocker A,Pilsmaker CD,Round SM,Tutt A,Glennie MJ,Marsh H,Keler T
14-0081 was used in Neutralization experiments to develop a fully human IgG1 mAb to human CD27 with agonist activity.
Tue Oct 15 00:00:00 EDT 2013
Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD
14-0081 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.
Tue Jan 01 00:00:00 EST 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-0081 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 EDT 2013
Cdc42 promotes host defenses against fatal infection.
Infection and immunity
Lee K,Boyd KL,Parekh DV,Kehl-Fie TE,Baldwin HS,Brakebusch C,Skaar EP,Boothby M,Zent R
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of Cdc42-dependent signalling in fibroblasts, showing that it promotes host defences against fatal infection.
Thu Aug 01 00:00:00 EDT 2013
CD38 controls the innate immune response against Listeria monocytogenes.
Infection and immunity
Lischke T,Heesch K,Schumacher V,Schneider M,Haag F,Koch-Nolte F,Mittrücker HW
14-0081 was used in Flow cytometry/Cell sorting to evaluate the key enzymes governing the innate immune response.
Fri Nov 01 00:00:00 EDT 2013
TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.
Developmental biology
Bai X,Trowbridge JJ,Riley E,Lee JA,DiBiase A,Kaartinen VM,Orkin SH,Zon LI
14-0081 was used in Flow cytometry/Cell sorting to study the role of TIF1γ in murine erythropoiesis and to assess its function in other blood lineages.
Tue Jan 15 00:00:00 EST 2013
In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.
PloS one
Cabrera M,Pewe LL,Harty JT,Frevert U
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Mar 18 00:00:00 EDT 2014
In vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected mice.
PloS one
Cabrera M,Pewe LL,Harty JT,Frevert U
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Mar 18 00:00:00 EDT 2014
A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.
PloS one
Schuster C,Brosi H,Stifter K,Boehm BO,Schirmbeck R
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Tue Apr 08 00:00:00 EDT 2014
A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.
PloS one
Schuster C,Brosi H,Stifter K,Boehm BO,Schirmbeck R
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Immunofluorescence
Tue Apr 08 00:00:00 EDT 2014
Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection.
PloS one
Obregón-Henao A,Henao-Tamayo M,Orme IM,Ordway DJ
14-0081 was used in Flow cytometry/Cell sorting to compare the bacterial burden, lung pathology and Gr1(int)CD11b(+) myeloid-derived suppressor cell immune responses in M. tuberculosis infected mice.
Fri Jun 20 00:00:00 EDT 2014
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
PloS one
Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.
Tue Oct 10 00:00:00 EDT 2017
Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection.
PloS one
Stoppelenburg AJ,Salimi V,Hennus M,Plantinga M,Huis in 't Veld R,Walk J,Meerding J,Coenjaerts F,Bont L,Boes M
14-0081 was used in Flow cytometry/Cell sorting to elucidate whether local IL-17A facilitates the innate neutrophil infiltration into RSV infected lungs prior to adaptive immunity.
Tue Feb 24 00:00:00 EST 2015
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Jun 13 00:00:00 EDT 2013
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
14-0081 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 EDT 2013
Neutrophils transport antigen from the dermis to the bone marrow, initiating a source of memory CD8+ T cells.
Immunity
Duffy D,Perrin H,Abadie V,Benhabiles N,Boissonnas A,Liard C,Descours B,Reboulleau D,Bonduelle O,Verrier B,Van Rooijen N,Combadière C,Combadière B
14-0081 was used in Immunocytochemistry to demonstrate how antigen is transported to the bone marrow, providing a source of virus-specific memory CD8+ T-cells.
Fri Nov 16 00:00:00 EST 2012
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0081 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-0081 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Blood
Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K
14-0081 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.
Thu Jun 14 00:00:00 EDT 2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-0081 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
The Journal of experimental medicine
Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of Tph-1 in regulation of immunity.
Mon Oct 22 00:00:00 EDT 2012
An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Murphy KA,Lechner MG,Popescu FE,Bedi J,Decker SA,Hu P,Erickson JR,O'Sullivan MG,Swier L,Salazar AM,Olin MR,Epstein AL,Ohlfest JR
14-0081 was used in Flow cytometry/Cell sorting to investigate the combination of a tumor lysate vaccine with a panel of costimulatory molecules for treatment of gliomas.
Sat Sep 01 00:00:00 EDT 2012
T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.
Cancer research
Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM
14-0081 was used in Immunohistochemistry on frozen tissues to evaluate the mechanisms by which activated lymphocytes fail to infiltrate tumours, showing concordance between low tumour growth, high T-cell infiltration and the presence of high endothelial venules promoted by Treg cells.
Thu Nov 01 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
14-0081 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.
Oncogene
Darlington Y,Nguyen TA,Moon SH,Herron A,Rao P,Zhu C,Lu X,Donehower LA
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.
European journal of immunology
Auger JL,Haasken S,Steinert EM,Binstadt BA
14-0081 was used in Flow cytometry/Cell sorting to highlight dual TCR-β expression as a mechanism that can enhance the maturation of autoreactive pathogenic T cells and lead to more rapid development of autoimmune disease.
Sat Sep 01 00:00:00 EDT 2012
Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung.
Journal of virology
Jennrich S,Lee MH,Lynn RC,Dewberry K,Debes GF
14-0081 was used in Flow cytometry/Cell sorting to find that in a murine model of influenza A virus infection, CD8 effector T cells migrated from the infected lung in a CCR7-dependent manner.
Sun Apr 01 00:00:00 EDT 2012
CTLA-4 blockade expands infiltrating T cells and inhibits cancer cell repopulation during the intervals of chemotherapy in murine mesothelioma.
Molecular cancer therapeutics
Wu L,Yun Z,Tagawa T,Rey-McIntyre K,de Perrot M
14-0081 was used in in vivo experiments to evaluate the impact of CTLA-4 blockade on the early stages of tumour development in a subcutaneous murine mesothelioma model.
Wed Aug 01 00:00:00 EDT 2012
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Ding X,Bian G,Leigh ND,Qiu J,McCarthy PL,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X
14-0081 was used in Flow cytometry/Cell sorting to investigate the effect of CBLB502 on graft-versus-tumour activity.
Thu Nov 15 00:00:00 EST 2012
Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Koga T,Ichinose K,Mizui M,Crispín JC,Tsokos GC
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that calcium/calmodulin-dependent protein kinase IV plays a central role in development of autoimmunity in MRL/lpr mice.
Mon Oct 01 00:00:00 EDT 2012
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
Journal of immunology (Baltimore, Md. : 1950)
Wensveen FM,Unger PP,Kragten NA,Derks IA,ten Brinke A,Arens R,van Lier RA,Eldering E,van Gisbergen KP
14-0081 was used in Flow cytometry/Cell sorting to investigate how BIm-dependent apoptosis is initiated in CD8 T cells.
Tue May 01 00:00:00 EDT 2012
Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Sawaguchi M,Tanaka S,Nakatani Y,Harada Y,Mukai K,Matsunaga Y,Ishiwata K,Oboki K,Kambayashi T,Watanabe N,Karasuyama H,Nakae S,Inoue H,Kubo M
14-0081 was used in Flow cytometry/Cell sorting to demonstrate an indispensable role for MCs as effector cells in AHR.
Wed Feb 15 00:00:00 EST 2012
Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.
Journal of immunology (Baltimore, Md. : 1950)
Yang RK,Kalogriopoulos NA,Rakhmilevich AL,Ranheim EA,Seo S,Kim K,Alderson KL,Gan J,Reisfeld RA,Gillies SD,Hank JA,Sondel PM
14-0081 was used in Immunohistochemistry to study how IT-IC resulted in increased numbers of activated T and NK cells within tumours, better IC retention in the tumour, enhanced inhibition of tumour growth, and improved survival compared with i.v.-IC.
Sat Sep 01 00:00:00 EDT 2012
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
Journal of immunology (Baltimore, Md. : 1950)
Zuklys S,Mayer CE,Zhanybekova S,Stefanski HE,Nusspaumer G,Gill J,Barthlott T,Chappaz S,Nitta T,Dooley J,Nogales-Cadenas R,Takahama Y,Finke D,Liston A,Blazar BR,Pascual-Montano A,Holländer GA
14-0081 was used in Flow cytometry/Cell sorting to investigate the cues provided by thymic epithelial cells to produce the differentiation of a diverse T cell repertoire, showing that microRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
Mon Oct 15 00:00:00 EDT 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
14-0081 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 EST 2012
Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Martin MD,Condotta SA,Harty JT,Badovinac VP
14-0081 was used in Flow cytometry/Cell sorting to investigate cell-autonomous functional differences between naive and memory CD8 T cells.
Wed Feb 01 00:00:00 EST 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.
Infection and immunity
Kanistanon D,Powell DA,Hajjar AM,Pelletier MR,Cohen IE,Way SS,Skerrett SJ,Wang X,Raetz CR,Ernst RK
14-0081 was used in Flow cytometry/Cell sorting to study the pathogenic effects of LPS modifications at the lipid A component of a Francisella novicida mutant.
Thu Mar 01 00:00:00 EST 2012
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.
Genesis (New York, N.Y. : 2000)
Berquam-Vrieze KE,Swing DA,Tessarollo L,Dupuy AJ
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2012
Characterization and use of a rabbit-anti-mouse VPAC1 antibody by flow cytometry.
Journal of immunological methods
Hermann RJ,Van der Steen T,Vomhof-Dekrey EE,Al-Badrani S,Wanjara SB,Failing JJ,Haring JS,Dorsam GP
14-0081 was used in Flow cytometry/Cell sorting to establish a well-characterized and species-specific α-mVPAC1 pAb for VPAC1 surface measurement.
Tue Feb 28 00:00:00 EST 2012
Recombinant lipidated HPV E7 induces a Th-1-biased immune response and protective immunity against cervical cancer in a mouse model.
PloS one
Huang CY,Chen JJ,Shen KY,Chang LS,Yeh YC,Chen IH,Chong P,Liu SJ,Leng CH
14-0081 was used in Functional assays to demonstrate that rlipo-E7m could be a promising candidate for treating HPV-associated tumors.
Wed Jan 16 00:00:00 EST 2013
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
14-0081 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 EDT 2012
CD69 does not affect the extent of T cell priming.
PloS one
Alari-Pahissa E,Notario L,Lorente E,Vega-Ramos J,Justel A,López D,Villadangos JA,Lauzurica P
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of CD69 in T cell activation, showing that CD69 does not affect the extent of T cell priming.
Mon May 06 00:00:00 EDT 2013
β-defensin 2 as an adjuvant promotes anti-melanoma immune responses and inhibits the growth of implanted murine melanoma in vivo.
PloS one
Mei HF,Jin XB,Zhu JY,Zeng AH,Wu Q,Lu XM,Li XB,Shen J
14-0081 was used in Flow cytometry/Cell sorting to evaluate possible function of β-defensin 2 as a positive regulator, promoting anti-tumour NK and T cell responses in vivo.
Tue Jul 31 00:00:00 EDT 2012
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression.
PloS one
Gao X,Zhu Y,Li G,Huang H,Zhang G,Wang F,Sun J,Yang Q,Zhang X,Lu B
14-0081 was used in Flow cytometry/Cell sorting to reveal a new role for TIM-3 as an important immune regulator in the tumour microenvironment.
Fri Jun 29 00:00:00 EDT 2012
Role of inflammasomes in host defense against Citrobacter rodentium infection.
The Journal of biological chemistry
Liu Z,Zaki MH,Vogel P,Gurung P,Finlay BB,Deng W,Lamkanfi M,Kanneganti TD
14-0081 was used in Flow cytometry/Cell sorting to investigate how mice lacking the inflammasome components Nlrp3, Nlrc4, and caspase-1 were hypersusceptible to C. rodentium-induced gastrointestinal inflammation.
Fri May 11 00:00:00 EDT 2012
Intranasal administration of dsRNA analog poly(I:C) induces interferon-α receptor-dependent accumulation of antigen experienced T cells in the airways.
PloS one
McNally B,Willette M,Ye F,Partida-Sanchez S,Flaño E
14-0081 was used in Flow cytometry/Cell sorting to elucidate the airway immune cell response to intranasally administered poly(I:C).
Tue Jun 11 00:00:00 EDT 2013
Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells.
PloS one
Schallenberg S,Petzold C,Tsai PY,Sparwasser T,Kretschmer K
14-0081 was used in Flow cytometry/Cell sorting to perform a comparative analysis of thymic Treg cell development and peripheral compartments of mature Treg cells in various transgenic Foxp3-fluorochrome reporter mouse strains.
Thu Jan 10 00:00:00 EST 2013
An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice.
PloS one
Barth T,Schmidt D,Botteron C,Nguyen TT,Ritter U,Männel DN,Lechner A
14-0081 was used in Flow cytometry/Cell sorting to analyse T cell subsets in the lymph nodes of CCR6-deficient mice over the course of Leishmania major infection.
Wed Mar 06 00:00:00 EST 2013
A subset of interleukin-21+ chemokine receptor CCR9+ T helper cells target accessory organs of the digestive system in autoimmunity.
Immunity
McGuire HM,Vogelzang A,Ma CS,Hughes WE,Silveira PA,Tangye SG,Christ D,Fulcher D,Falcone M,King C
14-0081 was used in Immunohistochemistry to characterise a T helper cell subset marked by coexpression of the cytokine interleukin 21 and CCR9.
Fri Apr 22 00:00:00 EDT 2011
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.
Immunity
Hall JA,Cannons JL,Grainger JR,Dos Santos LM,Hand TW,Naik S,Wohlfert EA,Chou DB,Oldenhove G,Robinson M,Grigg ME,Kastenmayer R,Schwartzberg PL,Belkaid Y
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid in responses to infection, showing that it is essential in the promotion of CD4(+) T cell effector responses.
Fri Mar 25 00:00:00 EDT 2011
Two-stage cooperative T cell receptor-peptide major histocompatibility complex-CD8 trimolecular interactions amplify antigen discrimination.
Immunity
Jiang N,Huang J,Edwards LJ,Liu B,Zhang Y,Beal CD,Evavold BD,Zhu C
14-0081 was used as a Control in experiments to delineate the trimolecular binding kinetics at the T cell membrane between the TCR, CD8 and pMHC glycoproteins.
Fri Jan 28 00:00:00 EST 2011
IL-10 elicits IFNγ-dependent tumor immune surveillance.
Cancer cell
Mumm JB,Emmerich J,Zhang X,Chan I,Wu L,Mauze S,Blaisdell S,Basham B,Dai J,Grein J,Sheppard C,Hong K,Cutler C,Turner S,LaFace D,Kleinschek M,Judo M,Ayanoglu G,Langowski J,Gu D,Paporello B,Murphy E,Sriram V,Naravula S,Desai B,Medicherla S,Seghezzi W,McClanahan T,Cannon-Carlson S,Beebe AM,Oft M
14-0081 was used in Neutralization experiments to demonstrate the contribution of IL-10 to immune cell function and therefore tumour growth.
Tue Dec 13 00:00:00 EST 2011
Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.
Gastroenterology
Aoki N,Kido M,Iwamoto S,Nishiura H,Maruoka R,Tanaka J,Watanabe T,Tanaka Y,Okazaki T,Chiba T,Watanabe N
14-0081 was used in Neutralization experiments to identify induction sites, responsible T-cell subsets, and key molecules for induction of autoimmune hepatitis.
Fri Apr 01 00:00:00 EDT 2011
GM-CSF in the lung protects against lethal influenza infection.
American journal of respiratory and critical care medicine
Huang FF,Barnes PF,Feng Y,Donis R,Chroneos ZC,Idell S,Allen T,Perez DR,Whitsett JA,Dunussi-Joannopoulos K,Shams H
14-0081 was used in Flow cytometry/Cell sorting to determine if increased expression of granulocyte/macrophage colony-stimulating factor in the lung increases resistance to influenza.
Fri Jul 15 00:00:00 EDT 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-0081 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
The Journal of clinical investigation
Sindrilaru A,Peters T,Wieschalka S,Baican C,Baican A,Peter H,Hainzl A,Schatz S,Qi Y,Schlecht A,Weiss JM,Wlaschek M,Sunderkötter C,Scharffetter-Kochanek K
14-0081 was used in Immunofluorescence to study human subjects with chronic venous leg ulcers and devise a human and mouse disease model for macrophage-driven chronic inflammation.
Tue Mar 01 00:00:00 EST 2011
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation
Nijagal A,Wegorzewska M,Jarvis E,Le T,Tang Q,MacKenzie TC
14-0081 was used in Flow cytometry/Cell sorting to investigate whether maternal cells trafficking into the fetus impose the barrier to effective in utero hematopoietic cell transplantation, showing that maternal T cells limit engraftment.
Tue Feb 01 00:00:00 EST 2011
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
14-0081 was used in Functional assays to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 EDT 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-0081 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 EST 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-0081 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 EST 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
14-0081 was used in Functional assays to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.
Mon Mar 14 00:00:00 EDT 2011
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine
Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2011
The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy.
Cancer research
Fu T,He Q,Sharma P
14-0081 was used in Flow cytometry/Cell sorting to identify mechanisms that elicit clinical benefit in the setting of anti-CTLA-4 therapy.
Mon Aug 15 00:00:00 EDT 2011
Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4(+) and CD8(+) T cells.
Cancer research
González-Martín A,Gómez L,Lustgarten J,Mira E,Mañes S
14-0081 was used in Flow cytometry/Cell sorting to investigate the relevance of the chemokine receptor CCR5 in tumoural immune control.
Mon Aug 15 00:00:00 EDT 2011
Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells.
Cancer research
Kitajima M,Ito T,Tumes DJ,Endo Y,Onodera A,Hashimoto K,Motohashi S,Yamashita M,Nishimura T,Ziegler SF,Nakayama T
14-0081 was used in Immunodepletion to demonstrate that memory Th2 cells can induce antitumor immunity through IL-4-induced activation of NK cells.
Fri Jul 15 00:00:00 EDT 2011
Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.
Proceedings of the National Academy of Sciences of the United States of America
Sauer JD,Pereyre S,Archer KA,Burke TP,Hanson B,Lauer P,Portnoy DA
14-0081 was used in Flow cytometry/Cell sorting to determine the consequences of inflammasome activation during infection and in the development of long-term immunity.
Tue Jul 26 00:00:00 EDT 2011
Centrosome docking at the immunological synapse is controlled by Lck signaling.
The Journal of cell biology
Tsun A,Qureshi I,Stinchcombe JC,Jenkins MR,de la Roche M,Kleczkowska J,Zamoyska R,Griffiths GM
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of Lck signalling in the control of centrosome docking at the immunological synapse.
Mon Feb 21 00:00:00 EST 2011
Polarized alloantigen presentation by airway epithelial cells contributes to direct CD8+ T cell activation in the airway.
American journal of respiratory cell and molecular biology
Kreisel D,Lai J,Richardson SB,Ibricevic A,Nava RG,Lin X,Li W,Kornfeld CG,Miller MJ,Brody SL,Gelman AE,Krupnick AS
14-0081 was used in Flow cytometry/Cell sorting to study alloantigen presentation by airway epithelial cells directing CD8+ T cell activation, and how this may be targeted clinically post transplantation.
Wed Jun 01 00:00:00 EDT 2011
IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.
European journal of immunology
Yang Q,Li G,Zhu Y,Liu L,Chen E,Turnquist H,Zhang X,Finn OJ,Chen X,Lu B
14-0081 was used in Flow cytometry/Cell sorting to study expression of the IL-33 receptor ST2 by type 1 cytotoxic T cells.
Tue Nov 01 00:00:00 EDT 2011
The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.
Journal of virology
Allen SJ,Hamrah P,Gate D,Mott KR,Mantopoulos D,Zheng L,Town T,Jones C,von Andrian UH,Freeman GJ,Sharpe AH,BenMohamed L,Ahmed R,Wechsler SL,Ghiasi H
14-0081 was used in Immunofluorescence to suggest that PD-1 and Tim-3 are facilitators of CD8(+) T cell exhaustion and dormancy in herpes simplex virus-1 infection.
Sun May 01 00:00:00 EDT 2011
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Published figure using CD8a monoclonal antibody (Product # 14-0081-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.
Journal of immunology (Baltimore, Md. : 1950)
Van Belle TL,Esplugues E,Liao J,Juntti T,Flavell RA,von Herrath MG
14-0081 was used in Flow cytometry/Cell sorting to elucidate the role of IL-17 in viral infections and type 1 diabetes.
Thu Sep 15 00:00:00 EDT 2011
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.
Journal of immunology (Baltimore, Md. : 1950)
Hoves S,Sutton VR,Haynes NM,Hawkins ED,Fernández Ruiz D,Baschuk N,Sedelies KA,Schnurr M,Stagg J,Andrews DM,Villadangos JA,Trapani JA
14-0081 was used in Flow cytometry/Cell sorting to reveal a critical and previously unsuspected role for granzymes A and B in dictating immunogenicity by influencing the mode of tumour cell death.
Mon Aug 01 00:00:00 EDT 2011
Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa Y,Takamatsu H,Okuno T,Kang S,Nojima S,Kimura T,Kataoka TR,Ikawa M,Toyofuku T,Katayama I,Kumanogoh A
14-0081 was used in Flow cytometry/Cell sorting to screen semaphorins for immune involvement, identifying Sema4B as a suppressor of basophil-mediated Th2-skewing.
Tue Mar 01 00:00:00 EST 2011
T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.
Journal of immunology (Baltimore, Md. : 1950)
Bou Ghanem EN,Nelson CC,D'Orazio SE
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive CD8(+) T cells to rapidly secrete IFN-γ.
Tue Feb 01 00:00:00 EST 2011
Peripheral T cells re-enter the thymus and interfere with central tolerance induction.
Journal of immunology (Baltimore, Md. : 1950)
Edelmann SL,Marconi P,Brocker T
14-0081 was used in Flow cytometry/Cell sorting to propose that adoptively transferred activated T cells can specifically alter the endogenous T cell repertoire.
Sun May 15 00:00:00 EDT 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-0081 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 EDT 2011
Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Weiss KA,Christiaansen AF,Fulton RB,Meyerholz DK,Varga SM
14-0081 was used in Flow cytometry/Cell sorting to evaluate the role of IL-10 in the modulation of the respiratory syncytial virus-specific immune response.
Thu Sep 15 00:00:00 EDT 2011
Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type I IFNs independent of H2-DM regulation.
Journal of immunology (Baltimore, Md. : 1950)
Strong BS,Unanue ER
14-0081 was used in Flow cytometry/Cell sorting to study the role of TLR ligands and interferons on the assembly of peptide-MHC II complexes.
Thu Sep 01 00:00:00 EDT 2011
Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.
PloS one
Petersen TR,Sika-Paotonu D,Knight DA,Simkins HM,Hermans IF
14-0081 was used in Flow cytometry/Cell sorting to investigate whether transfer of antigen between APCs is a mechanism to spread antigen to cells with specialised stimulatory functions.
Thu Mar 31 00:00:00 EDT 2011
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications
Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M
14-0081 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Tue Sep 20 00:00:00 EDT 2011
Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.
PloS one
Elpek KG,Bellemare-Pelletier A,Malhotra D,Reynoso ED,Lukacs-Kornek V,DeKruyff RH,Turley SJ
14-0081 was used in Flow cytometry/Cell sorting to investigate whether local environments can influence the transcriptome of DC subsets, showing that lymphoid organ-resident dendritic cells exhibit unique transcriptomes based on site.
Fri Feb 24 00:00:00 EST 2012
Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.
PloS one
Grespi F,Ottina E,Yannoutsos N,Geley S,Villunger A
14-0081 was used in Flow cytometry/Cell sorting to evaluate the suitability of the lac-operon/lac-repressor (lacO/lacI) system for the regulation of the Vav-gene promoter, and the importance of IPTG.
Mon Mar 21 00:00:00 EDT 2011
The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth.
Blood
Cavassani KA,Carson WF,Moreira AP,Wen H,Schaller MA,Ishii M,Lindell DM,Dou Y,Lukacs NW,Keshamouni VG,Hogaboam CM,Kunkel SL
14-0081 was used in Flow cytometry/Cell sorting to investigate the contribution of regulatory T cells to post sepsis immune defects and tumour growth.
Thu Jun 03 00:00:00 EDT 2010
Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells.
Blood
Coghill JM,Carlson MJ,Panoskaltsis-Mortari A,West ML,Burgents JE,Blazar BR,Serody JS
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of MHC disparity between donor and recipient, in the attenuated graft-versus-host disease responses of murine T cells lacking CCR7.
Thu Jun 10 00:00:00 EDT 2010
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Cancer research
Klages K,Mayer CT,Lahl K,Loddenkemper C,Teng MW,Ngiow SF,Smyth MJ,Hamann A,Huehn J,Sparwasser T
14-0081 was used in Flow cytometry/Cell sorting to suggest that selective Treg targeting strategies combined with vaccinations against tumor-associated (self) antigens have the potential to evoke efficient antitumor responses without inducing overt autoimmunity.
Fri Oct 15 00:00:00 EDT 2010
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.
Cancer research
Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G
14-0081 was used in Flow cytometry/Cell sorting to delineate the importance of IFNAR-dependent functions in TLR3-mediated tumour suppression.
Thu Apr 01 00:00:00 EDT 2010
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-0081 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 EDT 2010
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.
Proceedings of the National Academy of Sciences of the United States of America
Ishikawa E,Miyake Y,Hara H,Saito T,Yamasaki S
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying this ligand-independent pre-T-cell receptor (TCR) signalling in vivo, showing that germ-line elimination of electric charge on pre-T-cell receptor impairs autonomous signaling for beta-selection and TCR repertoire formation.
Tue Nov 16 00:00:00 EST 2010
Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence.
Proceedings of the National Academy of Sciences of the United States of America
Wakim LM,Woodward-Davis A,Bevan MJ
14-0081 was used in Immunohistochemistry to show that Trm are a specialised population of memory T cells, able to persist in tissues previously thought beyond immune surveillance.
Tue Oct 19 00:00:00 EDT 2010
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens
Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS
14-0081 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.
Fri Mar 19 00:00:00 EDT 2010
Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand.
Immunology and cell biology
Petersen TR,Sika-Paotonu D,Knight DA,Dickgreber N,Farrand KJ,Ronchese F,Hermans IF
14-0081 was used in Flow cytometry/Cell sorting to investigate the impact of eliciting T-cell help from activated iNKT cells using alpha-galactosylceramide, showing potent anti-tumour response.
Thu Jul 01 00:00:00 EDT 2010
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Stem cells (Dayton, Ohio)
Parmar K,Kim J,Sykes SM,Shimamura A,Stuckert P,Zhu K,Hamilton A,Deloach MK,Kutok JL,Akashi K,Gilliland DG,D'andrea A
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of Fancd2 and Usp1 in the maintenance and function of murine hematopoietic stem cells.
Thu Jul 01 00:00:00 EDT 2010
Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
Journal of immunology (Baltimore, Md. : 1950)
Gibbert K,Dietze KK,Zelinskyy G,Lang KS,Barchet W,Kirschning CJ,Dittmer U
14-0081 was used in Flow cytometry/Cell sorting to investigate the mode of action of poly(I:C) in antiretroviral immunotherapy.
Mon Nov 15 00:00:00 EST 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-0081 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-0081 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
Type I IFN signaling constrains IL-17A/F secretion by gammadelta T cells during bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Henry T,Kirimanjeswara GS,Ruby T,Jones JW,Peng K,Perret M,Ho L,Sauer JD,Iwakura Y,Metzger DW,Monack DM
14-0081 was used in Flow cytometry/Cell sorting to determine that type I IFN signalling might contribute to the resistance of mice to infection with other intracellular bacteria.
Thu Apr 01 00:00:00 EDT 2010
Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease.
Journal of immunology (Baltimore, Md. : 1950)
Akiyoshi H,Chung JS,Tomihari M,Cruz PD,Ariizumi K
14-0081 was used in Immunofluorescence to investigate whether the DC-HIL/SD-4 pathway could be a therapeutic target for conditions mediated by selectively activated T cells.
Thu Apr 01 00:00:00 EDT 2010
Differential in vivo clearance and response to secondary heterologous infections by H2(b)-restricted dengue virus-specific CD8+ T cells.
Viral immunology
Beaumier CM,Jaiswal S,West KY,Friberg H,Mathew A,Rothman AL
14-0081 was used in Flow cytometry/Cell sorting to investigate dengue virus-specific T-cell responses in mice.
Fri Oct 01 00:00:00 EDT 2010
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-0081 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 EDT 2009
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
Blood
Ryu SJ,Jung KM,Yoo HS,Kim TW,Kim S,Chang J,Choi EY
14-0081 was used in Flow cytometry/Cell sorting to provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response.
Thu Apr 30 00:00:00 EDT 2009
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.
The Journal of clinical investigation
Heymann F,Meyer-Schwesinger C,Hamilton-Williams EE,Hammerich L,Panzer U,Kaden S,Quaggin SE,Floege J,Gröne HJ,Kurts C
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of several immune cell types within tubulointerstitial mononuclear cell infiltrates in the progression of kidney disease.
Fri May 01 00:00:00 EDT 2009
CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice.
The Journal of clinical investigation
Menke J,Iwata Y,Rabacal WA,Basu R,Yeung YG,Humphreys BD,Wada T,Schwarting A,Stanley ER,Kelley VR
14-0081 was used in Immunohistochemistry on frozen tissues to assess whether CSF-1 has a therapeutic effect following ischaemia/reperfusion injury in mice.
Sat Aug 01 00:00:00 EDT 2009
Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis.
Hepatology (Baltimore, Md.)
Zhang W,Sharma R,Ju ST,He XS,Tao Y,Tsuneyama K,Tian Z,Lian ZX,Fu SM,Gershwin ME
14-0081 was used in Flow cytometry/Cell sorting to investigate whether development of autoimmune cholangitis would be found in mice deficient in components essential for the development and homeostasis of Foxp3+ Tregs.
Sun Feb 01 00:00:00 EST 2009
Migratory and antigen presentation functions of IFN-producing killer dendritic cells.
Cancer research
Himoudi N,Yan M,Bouma G,Morgenstern D,Wallace R,Seddon B,Buddle J,Eddaoudi A,Howe SJ,Cooper N,Anderson J
14-0081 was used in Flow cytometry/Cell sorting to study how BM-IKDCs are capable of cytotoxic killing of tumour targets, and also of potent antigen presentation after encountering antigen in the context of a viable target cell.
Sat Aug 15 00:00:00 EDT 2009
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Min B
14-0081 was used in Flow cytometry/Cell sorting to investigate the conditions and requirements of MHC and DCs for endogenous proliferation of different T-cell subsets.
Tue Dec 01 00:00:00 EST 2009
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.
Diabetes
Emamaullee JA,Davis J,Merani S,Toso C,Elliott JF,Thiesen A,Shapiro AM
14-0081 was used in Immunofluorescence to suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes.
Mon Jun 01 00:00:00 EDT 2009
The dendritic and T cell responses to herpes simplex virus-1 are modulated by dietary vitamin E.
Free radical biology & medicine
Sheridan PA,Beck MA
14-0081 was used in Neutralization experiments to investigate the role of vitamin E on response to herpes simplex virus-1.
Mon Jun 15 00:00:00 EDT 2009
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.
PLoS pathogens
Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.
Wed Apr 01 00:00:00 EDT 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-0081 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
L-arginine deprivation impairs Leishmania major-specific T-cell responses.
European journal of immunology
Munder M,Choi BS,Rogers M,Kropf P
14-0081 was used in Flow cytometry/Cell sorting to investigate the effects of L-arginine deprivation on antigen-specific T cells and macrophages.
Sat Aug 01 00:00:00 EDT 2009
Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.
Journal of virology
Khanolkar A,Hartwig SM,Haag BA,Meyerholz DK,Harty JT,Varga SM
14-0081 was used in Flow cytometry/Cell sorting to demonstrate that TLR4 plays an important role in respiratory CoV pathogenesis.
Tue Sep 01 00:00:00 EDT 2009
CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury.
The Journal of thoracic and cardiovascular surgery
Yang Z,Sharma AK,Linden J,Kron IL,Laubach VE
14-0081 was used in Neutralization experiments to show that CD4(+) T cells play a critical role in stimulating chemokine production and neutrophil chemotaxis during acute pulmonary ischemia-reperfusion injury.
Sun Mar 01 00:00:00 EST 2009
Critical roles of lysosomal acid lipase in T cell development and function.
The American journal of pathology
Qu P,Du H,Wilkes DS,Yan C
14-0081-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.
Sun Mar 01 00:00:00 EST 2009
Local expression of tumor necrosis factor-receptor 1:immunoglobulin G can induce salivary gland dysfunction in a murine model of Sjögren's syndrome.
Arthritis research & therapy
Vosters JL,Yin H,Roescher N,Kok MR,Tak PP,Chiorini JA
14-0081-82 was used in Immunohistochemistry to investigate the effect of a locally expressed tumor necrosis factor inhibitor on the salivary gland function and histopathology in an animal model of Sjögren's syndrome.
Thu May 20 00:00:00 EDT 2010
Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression.
Journal of immunology (Baltimore, Md. : 1950)
Wu C,Rauch U,Korpos E,Song J,Loser K,Crocker PR,Sorokin LM
14-0081 was used in Flow cytometry/Cell sorting to propose a new direct cell-cell interaction-based mechanism regulating the expansion of Tregs during autoimmune and inflammatory processes.
Fri May 15 00:00:00 EDT 2009
Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.
Journal of immunology (Baltimore, Md. : 1950)
Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.
Sun Nov 15 00:00:00 EST 2009
Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.
Journal of immunology (Baltimore, Md. : 1950)
Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.
Sun Nov 15 00:00:00 EST 2009
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.
Journal of immunology (Baltimore, Md. : 1950)
Farrand KJ,Dickgreber N,Stoitzner P,Ronchese F,Petersen TR,Hermans IF
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of langerin(+)CD8alpha(+) dendritic cells in priming T cells, showing that they are critical for cross-priming and IL-12 production in response to systemic antigens.
Tue Dec 15 00:00:00 EST 2009
Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.
Journal of immunology (Baltimore, Md. : 1950)
Farrand KJ,Dickgreber N,Stoitzner P,Ronchese F,Petersen TR,Hermans IF
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of langerin(+)CD8alpha(+) dendritic cells in priming T cells, showing that they are critical for cross-priming and IL-12 production in response to systemic antigens.
Tue Dec 15 00:00:00 EST 2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Virology
Steel CD,Hahto SM,Ciavarra RP
14-0081-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.
Sat Apr 25 00:00:00 EDT 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
14-0081 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0081-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0081-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Blood
Ahonen CL,Wasiuk A,Fuse S,Turk MJ,Ernstoff MS,Suriawinata AA,Gorham JD,Kedl RM,Usherwood EJ,Noelle RJ
14-0081 was used in Flow cytometry/Cell sorting to report the therapeutic effects of combinatorial use of CD40 and TLR agonists as a cancer vaccine.
Sat Mar 15 00:00:00 EDT 2008
Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.
Clinical immunology (Orlando, Fla.)
Kuerten S,Javeri S,Tary-Lehmann M,Lehmann PV,Angelov DN
14-0081 was used in Immunohistochemistry to investigate the histopathological differences between two mouse models of experimental autoimmune encephalomyelitis.
Sat Nov 01 00:00:00 EDT 2008
Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection.
Journal of virology
Kemball CC,Harkins S,Whitton JL
14-0081 was used in Flow cytometry/Cell sorting to evaluate CVB3 epitope-specific CD8(+) and CD4(+) T-cell responses in the spleen, heart and pancreas of mice in vivo.
Thu May 01 00:00:00 EDT 2008
Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950)
Cook L,Miyahara N,Jin N,Wands JM,Taube C,Roark CL,Potter TA,Gelfand EW,O'Brien RL,Born WK
14-0081 was used in Immunohistochemistry to study the mechanism by which dendritic cells enable the development of specific T cells that modulate airway hyperresponsiveness..
Tue Jul 01 00:00:00 EDT 2008
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 EDT 2008
Age-dependent tolerance to an endogenous tumor-associated antigen.
Vaccine
McWilliams JA,Sullivan RT,Jordan KR,McMahan RH,Kemmler CB,McDuffie M,Slansky JE
14-0081 was used in Flow cytometry/Cell sorting to determine the role of gp70 expression in the T cell response to a transplantable CT26 colon carcinoma tumour in mice.
Fri Mar 28 00:00:00 EDT 2008
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.
The Journal of biological chemistry
Kathrein KL,Chari S,Winandy S
14-0081 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional regulator Ikaros in the regulation of the transcriptional repressor of Hes1.
Fri Apr 18 00:00:00 EDT 2008
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
PloS one
Hase K,Takahashi D,Ebisawa M,Kawano S,Itoh K,Ohno H
14-0081 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying autoimmunity associated with AID mutations, showing that AID is a negative regulator of autoreactive B cells.
Thu Aug 21 00:00:00 EDT 2008
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation
Humblet-Baron S,Sather B,Anover S,Becker-Herman S,Kasprowicz DJ,Khim S,Nguyen T,Hudkins-Loya K,Alpers CE,Ziegler SF,Ochs H,Torgerson T,Campbell DJ,Rawlings DJ
14-0081 was used in Flow cytometry/Cell sorting to investigate whether alterations in Treg function might explain Wiskott-Aldrich syndrome pathology, showing that WASp is required for Treg homeostasis.
Thu Feb 01 00:00:00 EST 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-0081 was used in Flow cytometry/Cell sorting to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 EST 2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
14-0081-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40.
Journal of virology
Pinto AK,Jamieson AM,Raulet DH,Hill AB
14-0081 was used in Flow cytometry/Cell sorting to investigate role of NKG2D signalling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40.
Thu Nov 01 00:00:00 EDT 2007
Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.
The American journal of pathology
Crocker SJ,Frausto RF,Whitmire JK,Benning N,Milner R,Whitton JL
14-0081 was used in Flow cytometry/Cell sorting to show that TIMP-1 expression is induced in the myocardium by CVB3 infection.
Sat Dec 01 00:00:00 EST 2007
The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.
The American journal of pathology
Tamagawa-Mineoka R,Katoh N,Ueda E,Takenaka H,Kita M,Kishimoto S
14-0081 was used in Immunohistochemistry to demonstrate how controlling platelet activity may be useful for the treatment of chronic allergic dermatitis.
Fri Jun 01 00:00:00 EDT 2007
Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.
Molecular and cellular biology
Tenno M,Ohtsubo K,Hagen FK,Ditto D,Zarbock A,Schaerli P,von Andrian UH,Ley K,Le D,Tabak LA,Marth JD
14-0081 was used in Flow cytometry/Cell sorting to find that ppGalNAcT-1 plays key roles in cell and glycoprotein selective functions that modulate the haematopoietic system.
Sat Dec 01 00:00:00 EST 2007
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.
The Journal of biological chemistry
Grigorian A,Lee SU,Tian W,Chen IJ,Gao G,Mendelsohn R,Dennis JW,Demetriou M
14-0081 was used in Flow cytometry/Cell sorting to investigate how the environment influences susceptibility to autoimmunity, showing that autoimmunity can be controlled through metabolite flux to N-glycan biosynthesis.
Fri Jul 06 00:00:00 EDT 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-0081 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 EST 2007
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 EST 2006
Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.
Journal of autoimmunity
Sharma R,Zheng L,Guo X,Fu SM,Ju ST,Jarjour WN
14-0081 was used in Flow cytometry/Cell sorting to investigate whether salivary and lacrimal glands are targeted in IL-2 knockout, IL-2Ralpha KO and scurfy mice.
Fri Dec 01 00:00:00 EST 2006
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.jpg?time=20240507?time=20240507 "CD8a Antibody (14-0081-82) in ICC/IF")
.jpg?time=20240507?time=20240507 "CD8a Antibody (14-0081-82) in ICC/IF")
