Product References
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
25-5698-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses.
Cancer immunology research
Fedoriw A,Shi L,O'Brien S,Smitheman KN,Wang Y,Hou J,Sherk C,Rajapurkar S,Laraio J,Williams LJ,Xu C,Han G,Feng Q,Bedford MT,Wang L,Barbash O,Kruger RG,Hwu P,Mohammad HP,Peng W
25-5698-82 was used in Flow cytometry/Cell sorting to indicate that type I PRMT inhibition exhibits immunomodulatory properties and synergizes with immune checkpoint blockade to induce durable antitumor responses in a T cell-dependent manner, suggesting that type I PRMT inhibition can potentiate an antitumor immunity in refractory settings.
Fri Apr 01 00:00:00 EDT 2022
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
Nature communications
Chiang HY,Lu HH,Sudhakar JN,Chen YW,Shih NS,Weng YT,Shui JW
25-5698-82 was used in Flow Cytometry to conclude that IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5+ stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ+ T cells.
Tue Feb 15 00:00:00 EST 2022
Functional virus-specific memory T cells survey glioblastoma.
Cancer immunology, immunotherapy : CII
Ning J,Gavil NV,Wu S,Wijeyesinghe S,Weyu E,Ma J,Li M,Grigore FN,Dhawan S,Skorput AGJ,Musial SC,Chen CC,Masopust D,Rosato PC
25-5698-82 was used in Flow cytometry/Cell sorting to indicate that virus-specific memory T cells are a significant part of the glioblastoma immune microenvironment and may be leveraged to promote anti-tumoral immunity.
Mon Aug 01 00:00:00 EDT 2022
Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells.
Genes & diseases
Yang L,Jing Y,Kang D,Jiang P,Li N,Zhou X,Chen Y,Westerberg LS,Liu C
25-5698-82 was used in Flow Cytometry to identify the role of USP18 in Tregs differentiation and its suppressive function.
Sat May 01 00:00:00 EDT 2021
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
The Journal of clinical investigation
Tilstam PV,Schulte W,Holowka T,Kim BS,Nouws J,Sauler M,Piecychna M,Pantouris G,Lolis E,Leng L,Bernhagen J,Fingerle-Rowson G,Bucala R
25-5698-82 was used in flow cytometry to study Mif-/- and Mif-2-/- mice to polymicrobial sepsis and observed a survival benefit with Mif but not Mif-2 deficiency.
Wed Dec 01 00:00:00 EST 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
25-5698-82 was used in Flow Cytometry to understand the molecular mechanism underlying the generation of follicular helper T cells.
Mon Dec 20 00:00:00 EST 2021
Obesity results in adipose tissue T cell exhaustion.
JCI insight
Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN
25-5698-82 was used in Flow Cytometry to assess adipose tissue T cells activation and inflammatory potential within mouse and human stromal vascular fraction.
Thu Apr 22 00:00:00 EDT 2021
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
25-5698-82 was used in Flow Cytometry to reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.
Thu Jan 09 00:00:00 EST 2020
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential.
Nature immunology
Derecka M,Herman JS,Cauchy P,Ramamoorthy S,Lupar E,Grün D,Grosschedl R
25-5698-82 was used in Flow Cytometry to investigate how transcriptional changes in bone marrow (BM) mesenchymal stromal cells result in long-lasting effects on hematopoietic stem cells.
Sun Mar 01 00:00:00 EST 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
25-5698 was used in Flow cytometry/Cell sorting to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 EST 2020
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
25-5698-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 EDT 2020
CX3CR1 positively regulates BCR signaling coupled with cell metabolism via negatively controlling actin remodeling.
Cellular and molecular life sciences : CMLS
Li N,Jiang P,Chen A,Luo X,Jing Y,Yang L,Kang D,Chen Q,Liu J,Chang J,Jellusova J,Miller H,Westerberg L,Wang CY,Gong Q,Liu C
25-5698-82 was used in Flow Cytometry to study the effect of CX3CR1 deficiency on BCR signalling and B cell differentiation using CX3CR1 KO mice.
Sun Nov 01 00:00:00 EDT 2020
Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis.
The Journal of investigative dermatology
Özcan A,Sahin D,Impellizzieri D,Nguyen TT,Hafner J,Yawalkar N,Kurzbach D,Tan G,Akdis CA,Nilsson J,Boyman O,Kolios AGA
25-5698 was used in Flow cytometry/Cell sorting to show that MTX coupled with gold nanoparticles (GNPs) demonstrates superior antiinflammatory efficacy than MTX alone in an imiquimod-induced mouse model, significantly reducing γδ T cells, CD4+ T cells, and neutrophils.
Fri May 01 00:00:00 EDT 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
25-5698 was used in Flow cytometry/Cell sorting to study the mechanism that controls the development of αβ T cell lineages in the thymus.
Mon May 04 00:00:00 EDT 2020
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.
Nature communications
Harsha Krovi S,Zhang J,Michaels-Foster MJ,Brunetti T,Loh L,Scott-Browne J,Gapin L
25-5698 was used in Flow cytometry/Cell sorting to highlight the common requirements for the development of innate-like T cells with a focus on how Hivep3 impacts the maturation of these lymphocytes.
Mon Dec 07 00:00:00 EST 2020
Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection.
Cell reports
Sandu I,Cerletti D,Oetiker N,Borsa M,Wagen F,Spadafora I,Welten SPM,Stolz U,Oxenius A,Claassen M
25-5698-82 was used in Flow Cytometry to reveal that exhausted cells are heterogeneous, adopt organ-specific transcriptomic profiles, and can be divided into five main functional subpopulations: advanced exhaustion, effector-like, intermediate, proliferating, or memory-like.
Tue Aug 25 00:00:00 EDT 2020
Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.
Nature communications
Sudhakar JN,Lu HH,Chiang HY,Suen CS,Hwang MJ,Wu SY,Shen CN,Chang YM,Li FA,Liu FT,Shui JW
25-5698 was used in Flow cytometry/Cell sorting to show in gut epithelial cells, galectin-9 is enriched in lysosomes and predominantly binds to lysosome-associated membrane protein 2 (Lamp2) in a Asn(N)-glycan dependent manner.
Thu Aug 27 00:00:00 EDT 2020
A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves.
Immunity
Kolter J,Feuerstein R,Zeis P,Hagemeyer N,Paterson N,d'Errico P,Baasch S,Amann L,Masuda T,Lösslein A,Gharun K,Meyer-Luehmann M,Waskow C,Franzke CW,Grün D,Lämmermann T,Prinz M,Henneke P
25-5698 was used in Flow cytometry/Cell sorting to delineate the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging.
Tue Jun 18 00:00:00 EDT 2019
Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.
Immunity
Wallrapp A,Burkett PR,Riesenfeld SJ,Kim SJ,Christian E,Abdulnour RE,Thakore PI,Schnell A,Lambden C,Herbst RH,Khan P,Tsujikawa K,Xavier RJ,Chiu IM,Levy BD,Regev A,Kuchroo VK
25-5698-82 was used in Flow Cytometry to show that ILC2s expressed both the neuropeptide calcitonin gene-related peptide and its receptor.
Tue Oct 15 00:00:00 EDT 2019
Causes and Consequences of miR-150-5p Dysregulation in Myasthenia Gravis.
Frontiers in immunology
Cron MA,Maillard S,Truffault F,Gualeni AV,Gloghini A,Fadel E,Guihaire J,Behin A,Berrih-Aknin S,Le Panse R
25-5698 was used in Flow cytometry/Cell sorting to show miR-150-5p dysregulation can increase death of CD4+ and CD8+ T cells and induce overexpression of pro-apoptotic genes normally targeted by miR-150.
Tue Aug 04 00:00:00 EDT 2020
The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis-Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation.
Immunity
Wang D,Diao H,Getzler AJ,Rogal W,Frederick MA,Milner J,Yu B,Crotty S,Goldrath AW,Pipkin ME
25-5698 was used in Flow cytometry/Cell sorting to conclude that Runx3 governs chromatin accessibility during TCR stimulation and enforces the memory CTL developmental program.
Tue Apr 17 00:00:00 EDT 2018
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
25-5698-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 EST 2017
Intestinal helminth infection induces highly functional resident memory CD4+ T cells in mice.
European journal of immunology
Steinfelder S,Rausch S,Michael D,Kühl AA,Hartmann S
25-5698 was used in Flow cytometry/Cell sorting to show that nonlymphoid compartments can serve as reservoirs for Th2 memory cells, and furthermore that innate effector function of Th2 memory cells is restricted to CD4⁺ memory T cells residing in the peritoneal cavity.
Wed Feb 01 00:00:00 EST 2017
Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Michel C,Miller CN,Küchler R,Brors B,Anderson MS,Kyewski B,Pinto S
25-5698 was used in Flow cytometry/Cell sorting to introduce the lectin Tetragonolobus purpureas agglutinin as a novel cell surface marker that allows for such delineation.
Wed Nov 15 00:00:00 EST 2017
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
25-5698 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
25-5698 was used in Flow cytometry/Cell sorting to identify a novel pathway of cross-talk between macrophages and dendritic cells.
Sat Oct 01 00:00:00 EDT 2016
SWEF Proteins Distinctly Control Maintenance and Differentiation of Hematopoietic Stem Cells.
PloS one
Ripich T,Chacón-Martínez CA,Fischer L,Pernis A,Kiessling N,Garbe AI,Jessberger R
25-5698 was used in Flow cytometry/Cell sorting to investigate the role of SWAP-70 and DEF6 in hematopoietic stem and precursor cells.
Mon Jul 31 00:00:00 EDT 2017
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Nature communications
Spanier JA,Frederick DR,Taylor JJ,Heffernan JR,Kotov DI,Martinov T,Osum KC,Ruggiero JL,Rust BJ,Landry SJ,Jenkins MK,McLachlan JB,Fife BT
25-5698 was used in Flow cytometry/Cell sorting to develop a novel approach for the generation and screening of peptide:MHCII reactive mAbs that exploits the use of recombinant peptide:MHC monomers as immunogens.
Mon Jun 13 00:00:00 EDT 2016
IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment.
PloS one
Mahr B,Unger L,Hock K,Pilat N,Baranyi U,Schwarz C,Maschke S,Farkas AM,Wekerle T
25-5698 was used in Flow cytometry/Cell sorting to investigate IL-2 complex treatment as a replacement for regulatory T cell adoptive transfer to promote bone marrow engraftment.
Thu Jun 30 00:00:00 EDT 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
25-5698 was used in Flow cytometry/Cell sorting to study how tumour eradication can be controlled by interdependent IL-7 and IFN-γ signalling in T-cells.
Mon Aug 08 00:00:00 EDT 2016
Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.
International journal for parasitology
Bourke CD,Prendergast CT,Sanin DE,Oulton TE,Hall RJ,Mountford AP
25-5698 was used in Flow cytometry/Cell sorting to indicate that S.mansoni cercariae and their excretory/secretory products act directly upon epidermal keratinocytes.
Sun Mar 01 00:00:00 EST 2015
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.
Nature immunology
Pang IK,Ichinohe T,Iwasaki A
Fri Mar 01 00:00:00 EST 2013
Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens.
Journal of immunology (Baltimore, Md. : 1950)
Yammani RD,Haas KM
Mon Apr 01 00:00:00 EDT 2013
Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.
PloS one
Liu J,Copland DA,Horie S,Wu WK,Chen M,Xu Y,Paul Morgan B,Mack M,Xu H,Nicholson LB,Dick AD
Thu Jan 15 00:00:00 EST 2015
