Product References
BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity.
Journal for immunotherapy of cancer
Wu B,Qi L,Chiang HC,Pan H,Zhang X,Greenbaum A,Stark E,Wang LJ,Chen Y,Haddad BR,Clagett D,Isaacs C,Elledge R,Horvath A,Hu Y,Li R
48-5698-82 was used in Flow cytometry/Cell sorting to report that mouse Brca1 knockout (KO) in mature T lymphocytes compromises host antitumor immune response to transplanted syngeneic mouse mammary tumors.
Wed Feb 01 00:00:00 EST 2023
Spermatogonial fate in mice with increased activin A bioactivity and testicular somatic cell tumours.
Frontiers in cell and developmental biology
Whiley PAF,Nathaniel B,Stanton PG,Hobbs RM,Loveland KL
48-5698-82 was used in Flow cytometry/Cell sorting to show for the first time that chronically elevated activin A affects spermatogonial stem cells fate in vivo.
Sat Aug 12 00:00:00 EDT 2023
Toll-like receptor mediated inflammation directs B cells towards protective antiviral extrafollicular responses.
Nature communications
Lam JH,Baumgarth N
48-5698-82 was used in Flow cytometry/Cell sorting to show that influenza infection rapidly induces EFRs, generating protective antibodies via Toll-like receptor (TLR)-mediated mechanisms that are both B cell intrinsic and extrinsic.
Wed Jul 05 00:00:00 EDT 2023
Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment.
Nature communications
Reda M,Ngamcherdtrakul W,Nelson MA,Siriwon N,Wang R,Zaidan HY,Bejan DS,Reda S,Hoang NH,Crumrine NA,Rehwaldt JPC,Bindal A,Mills GB,Gray JW,Yantasee W
48-5698-82 was used in Flow cytometry/Cell sorting to highlight a rational combination strategy to augment existing therapies by utilizing our nanoparticle platform that can load multiple cargo types at once.
Sat Jul 23 00:00:00 EDT 2022
Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment.
Nature communications
Reda M,Ngamcherdtrakul W,Nelson MA,Siriwon N,Wang R,Zaidan HY,Bejan DS,Reda S,Hoang NH,Crumrine NA,Rehwaldt JPC,Bindal A,Mills GB,Gray JW,Yantasee W
48-5698-82 was used in Flow cytometry/Cell sorting to highlight a rational combination strategy to augment existing therapies by utilizing our nanoparticle platform that can load multiple cargo types at once.
Sat Jul 23 00:00:00 EDT 2022
Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.
iScience
Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS
48-5698-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.
Fri Jun 17 00:00:00 EDT 2022
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
48-5698-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 EST 2022
The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
eLife
Li S,Bern MD,Miao B,Fan C,Xing X,Inoue T,Piersma SJ,Wang T,Colonna M,Kurosaki T,Yokoyama WM
48-5698-82 was used in Flow cytometry/Cell sorting to investigate the role of Bach2 in natural killer (NK) cell development, revealing that Bach2 expression peaked in immature CD27+CD11b+ cells, and its deficiency led to increased proportions of terminally differentiated NK cells with enhanced granzyme and cytokine production, as well as improved NK cell-mediated control of tumor metastasis.
Mon Oct 03 00:00:00 EDT 2022
Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages.
eLife
Lopes N,Boucherit N,Santamaria JC,Provin N,Charaix J,Ferrier P,Giraud M,Irla M
48-5698-82 was used in Flow cytometry/Cell sorting to reveal that self-reactive CD4+ thymocytes control multiple unsuspected facets from immature stages of mTECs, which determines their heterogeneity.
Mon Feb 21 00:00:00 EST 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
48-5698-82 was used in Flow Cytometry to determine response to chemical signalling caused by endogenous retrovirus in skin microbiota.
Thu Jul 08 00:00:00 EDT 2021
Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses.
Cancer research
Cousin N,Cap S,Dihr M,Tacconi C,Detmar M,Dieterich LC
48-5698-82 was used in Immunocytochemistry to present a new lymphatic-specific PD-L1 knockout mouse model reveals that lymphatic endothelial PD-L1 expression reduces tumor immunity, inducing apoptosis in tumor-specific CD8+ central memory cells in tumor-draining lymph nodes.
Sun Aug 01 00:00:00 EDT 2021
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
mAbs
Schofield DJ,Percival-Alwyn J,Rytelewski M,Hood J,Rothstein R,Wetzel L,McGlinchey K,Adjei G,Watkins A,Machiesky L,Chen W,Andrews J,Groves M,Morrow M,Stewart RA,Leinster A,Wilkinson RW,Hammond SA,Luheshi N,Dobson C,Oberst M
48-5698-82 was used in Flow cytometry/Cell sorting to show that anti-PD-L1 and anti-CTLA-4 murine surrogates with pharmacologic properties similar to those of durvalumab and tremelimumab demonstrated anti-tumor activity in a subset of commonly used mouse syngeneic tumor models.
Thu Oct 14 00:00:00 EDT 2021
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
mAbs
Schofield DJ,Percival-Alwyn J,Rytelewski M,Hood J,Rothstein R,Wetzel L,McGlinchey K,Adjei G,Watkins A,Machiesky L,Chen W,Andrews J,Groves M,Morrow M,Stewart RA,Leinster A,Wilkinson RW,Hammond SA,Luheshi N,Dobson C,Oberst M
48-5698-82 was used in Flow cytometry/Cell sorting to show that anti-PD-L1 and anti-CTLA-4 murine surrogates with pharmacologic properties similar to those of durvalumab and tremelimumab demonstrated anti-tumor activity in a subset of commonly used mouse syngeneic tumor models.
Thu Oct 14 00:00:00 EDT 2021
Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells.
Proceedings of the National Academy of Sciences of the United States of America
Ronin E,Pouchy C,Khosravi M,Hilaire M,Grégoire S,Casrouge A,Kassem S,Sleurs D,Martin GH,Chanson N,Lombardi Y,Lalle G,Wajant H,Auffray C,Lucas B,Marodon G,Grinberg-Bleyer Y,Salomon BL
48-5698-82 was used in Flow cytometry/Cell sorting to show that endogenous Treg cells specifically suppress an autoimmune disease by acting in the target tissue during overt inflammation.
Tue Mar 30 00:00:00 EDT 2021
Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation.
Journal for immunotherapy of cancer
Wu B,Chiang HC,Sun X,Yuan B,Mitra P,Hu Y,Curiel TJ,Li R
48-5698 was used in Flow cytometry/Cell sorting to uncover a previously unrecognised role of adipocyte PD-L1 in mitigating obesity-related inflammation and metabolic dysfunction.
Sat Aug 01 00:00:00 EDT 2020
Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses.
Cell reports
Diaz-Salazar C,Sun JC
48-5698 was used in Flow cytometry/Cell sorting to support a mechanism whereby cytotoxic innate and adaptive lymphocytes cooperate to ensure viral clearance and the establishment of robust clonal NK cell responses.
Tue Sep 22 00:00:00 EDT 2020
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.
Nature communications
Harsha Krovi S,Zhang J,Michaels-Foster MJ,Brunetti T,Loh L,Scott-Browne J,Gapin L
48-5698 was used in Flow cytometry/Cell sorting to highlight the common requirements for the development of innate-like T cells with a focus on how Hivep3 impacts the maturation of these lymphocytes.
Mon Dec 07 00:00:00 EST 2020
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer.
Journal for immunotherapy of cancer
Bai F,Zhang P,Fu Y,Chen H,Zhang M,Huang Q,Li D,Li B,Wu K
48-5698 was used in Flow cytometry/Cell sorting to show that ANXA1 expression is associated with lower survival and a higher risk of breast malignancy.
Wed Apr 01 00:00:00 EDT 2020
TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Cell reports
Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP
48-5698 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.
Tue Apr 07 00:00:00 EDT 2020
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
48-5698-82 was used in Flow Cytometry to show that during obesity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance and impaired glucose and lipid metabolism.
Fri Jul 24 00:00:00 EDT 2020
MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation.
Haematologica
Crisafulli L,Muggeo S,Uva P,Wang Y,Iwasaki M,Locatelli S,Anselmo A,Colombo FS,Carlo-Stella C,Cleary ML,Villa A,Gentner B,Ficara F
48-5698 was used in Flow cytometry/Cell sorting to investigate the contribution of micro-RNA in the regulation of self-renewal vs differentiation.
Sun Sep 01 00:00:00 EDT 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
48-5698 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 EDT 2019
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
48-5698 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice.
Proceedings of the National Academy of Sciences of the United States of America
Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER
48-5698 was used in Flow cytometry/Cell sorting to study the role of resident macrophages of the pancreatic islets in the initiation of autoimmune diabetes of NOD mice.
Tue Nov 28 00:00:00 EST 2017
Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.
Mucosal immunology
Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL
48-5698 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.
Mon May 01 00:00:00 EDT 2017
Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion.
The Journal of investigative dermatology
Donovan P,Dubey OA,Kallioinen S,Rogers KW,Muehlethaler K,Müller P,Rimoldi D,Constam DB
48-5698 was used in Immunocytochemistry to test whether a potential tumorigenic role for Activin signaling in melanoma may be curtailed in xenografts by the absence of a functional immune system.
Fri Dec 01 00:00:00 EST 2017
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.
Science (New York, N.Y.)
Soucie EL,Weng Z,Geirsdóttir L,Molawi K,Maurizio J,Fenouil R,Mossadegh-Keller N,Gimenez G,VanHille L,Beniazza M,Favret J,Berruyer C,Perrin P,Hacohen N,Andrau JC,Ferrier P,Dubreuil P,Sidow A,Sieweke MH
48-5698 was used in Flow cytometry/Cell sorting to investigate the mechanisms that accomplish self-renewal of differentiated macrophages.
Fri Feb 12 00:00:00 EST 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
48-5698 was used in Flow cytometry/Cell sorting to show in mice, that maternal hepatitis B virus (HBV) impairs CD8(+) T cell responses to HBV in her offspring, resulting in HBV persistence.
Tue May 17 00:00:00 EDT 2016
A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells.
PLoS pathogens
Ersching J,Basso AS,Kalich VL,Bortoluci KR,Rodrigues MM
48-5698 was used in Flow cytometry/Cell sorting to demonstrate a newly described mechanism of CD8+ T cell priming by CD4+ Foxp3+ T cells during Trypanosoma cruzi infection.
Wed Jun 01 00:00:00 EDT 2016
Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors.
EBioMedicine
Holmgaard RB,Zamarin D,Lesokhin A,Merghoub T,Wolchok JD
48-5698 was used in Flow cytometry/Cell sorting to study the invovlement of myeloid-derived suppressor cells in IDO-expressing B16 tumour progression and therapy resistance.
Fri Apr 01 00:00:00 EDT 2016
Beta-Chemokine CCL15 Affects the Adhesion and Migration of Hematopoietic Progenitor Cells.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
Richter R,Rüster B,Bistrian R,Forssmann WG,Seifried E,Henschler R
48-5698 was used in Flow cytometry/Cell sorting to point to a regulation of HPCs by CCL15 and ultimately improve HPC short-term engraftment in stem cell transplantation.
Thu Jan 01 00:00:00 EST 2015
Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Little MC,Hurst RJ,Else KJ
48-5698 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.
Sat Nov 01 00:00:00 EDT 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
48-5698 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 EST 2014
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
48-5698 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.
Nature immunology
Pang IK,Ichinohe T,Iwasaki A
Fri Mar 01 00:00:00 EST 2013
Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens.
Journal of immunology (Baltimore, Md. : 1950)
Yammani RD,Haas KM
Mon Apr 01 00:00:00 EDT 2013
Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.
PloS one
Liu J,Copland DA,Horie S,Wu WK,Chen M,Xu Y,Paul Morgan B,Mack M,Xu H,Nicholson LB,Dick AD
Thu Jan 15 00:00:00 EST 2015
