Product References
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.
Nature communications
Wiedmann L,De Angelis Rigotti F,Vaquero-Siguero N,Donato E,Espinet E,Moll I,Alsina-Sanchis E,Bohnenberger H,Fernandez-Florido E,Mülfarth R,Vacca M,Gerwing J,Conradi LC,Ströbel P,Trumpp A,Mogler C,Fischer A,Rodriguez-Vita J
12-0251-82 was used in Flow cytometry/Cell sorting to identify hyaluronan and proteoglycan link protein-1 (HAPLN1) as a prognostic marker and as a driver for peritoneal metastasis in pancreatic ductal adenocarcinoma.
Mon Apr 24 00:00:00 EDT 2023
Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy.
Nature communications
Liu X,Zhuang Y,Huang W,Wu Z,Chen Y,Shan Q,Zhang Y,Wu Z,Ding X,Qiu Z,Cui W,Wang Z
12-0251-82 was used in Flow cytometry/Cell sorting to show in an orthotopic pancreatic cancer model in male mice that the hydrogel microsphere vaccine transforms the immunologically cold tumour microenvironment into hot in a safe and efficient manner, thus significantly increasing survival and inhibiting the growth of distant metastases.
Tue Jul 11 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
12-0251-82 was used in Immunohistochemistry to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 EST 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
12-0251-82 was used in Flow cytometry/Cell sorting to identify Aiolos as a pivotal regulator of CD4-CTL and TFH programming and highlight its potential as a target for manipulating CD4+ T cell responses.
Fri Mar 24 00:00:00 EDT 2023
Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis.
FEBS open bio
No authors listed
12-0251 was used in Flow cytometry/Cell sorting to suggest that Parecoxib inhibits the inflammatory response and has protective effects against sepsis in mice, and may have potential as a novel therapeutic method for treating sepsis.
Sat Jan 01 00:00:00 EST 2022
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2.
Nature communications
Wilson AS,Randall KL,Pettitt JA,Ellyard JI,Blumenthal A,Enders A,Quah BJ,Bopp T,Parish CR,Brüstle A
12-0251-82 was used in Flow Cytometry to show that neutrophil extracellular traps, web-like DNA structures which are extruded from neutrophils upon activation, through their protein component histones, directly activate T cells and specifically enhance Th17 cell differentiation.
Wed Jan 26 00:00:00 EST 2022
Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer.
Frontiers in immunology
Crupi MJF,Taha Z,Janssen TJA,Petryk J,Boulton S,Alluqmani N,Jirovec A,Kassas O,Khan ST,Vallati S,Lee E,Huang BZ,Huh M,Pikor L,He X,Marius R,Austin B,Duong J,Pelin A,Neault S,Azad T,Breitbach CJ,Stojdl DF,Burgess MF,McComb S,Auer R,Diallo JS,Ilkow CS,Bell JC
12-0251-82 was used in Flow cytometry/Cell sorting to establish combination regimens with immune checkpoint inhibitors for aggressive colorectal peritoneal metastases.
Tue Nov 22 00:00:00 EST 2022
Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells.
Frontiers in microbiology
Wu Y,Li D,Wang H,Wan X
12-0251-82 was used in Flow cytometry/Cell sorting to show that PCPs have pharmacological and biological effects on FP-induced septic mice, and its molecular mechanism is related to antioxidative, anti-inflammation, anti-apoptosis, and the reduction of Treg activity in splenic cells.
Sat Jul 16 00:00:00 EDT 2022
Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways.
Frontiers in immunology
Dong X,Zhang J,Zhang Q,Liang Z,Xu Y,Zhao Y,Zhang B
12-0251-82 was used in Flow cytometry/Cell sorting to reveal that Dhx9, a cytosolic nuclear sensor recognizes viral DNA or RNA, playing an important role in mTEC development and function in mice.
Tue Jun 21 00:00:00 EDT 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
12-0251-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
12-0251-82 was used in Flow Cytometry to reveal that the expression of epigenetic regulator Sirt6 in TECs is crucial for the development and differentiation of mTECs, which highlights the importance of Sirt6 in the establishment of central immune tolerance.
Wed Apr 21 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
12-0251 was used in Flow cytometry/Cell sorting to indicate that cell-permeable transgelin-2 have a potential clinical value as a cancer immunotherapy based on DCs.
Wed Mar 17 00:00:00 EDT 2021
Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis.
BMC endocrine disorders
Wei Y,Jing J,Peng Z,Liu X,Wang X
12-0251 was used in Flow cytometry/Cell sorting to show that MiR-23b-3p offset the effects of acacetin on body weight, fat percent, inflammatory cytokines levels and expressions of markers of regulatory T cells (Treg cells) and T helper 17 cells (Th17 cells), NEU1 and miR-23b-3p.
Mon Mar 29 00:00:00 EDT 2021
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Science advances
Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J
12-0251 was used in Flow cytometry/Cell sorting to test a hypothesis that an age-related reduction in C-C chemokine receptor type 7 (CCR7)-dependent egress of immune cells through the lymphatic vasculature mediates some aspects of brain aging and potentially exacerbates cognitive decline and Alzheimer's disease-like brain β-amyloid (Aβ) pathology.
Sat May 01 00:00:00 EDT 2021
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.
Immunity
McGinley AM,Sutton CE,Edwards SC,Leane CM,DeCourcey J,Teijeiro A,Hamilton JA,Boon L,Djouder N,Mills KHG
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that a key function of IL-17A in central nervous system (CNS) autoimmunity is to recruit IL-1β-secreting myeloid cells that prime pathogenic γδT17 and Th17 cells.
Tue Feb 18 00:00:00 EST 2020
Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Eixarch H,Calvo-Barreiro L,Costa C,Reverter-Vives G,Castillo M,Gil V,Del Río JA,Montalban X,Espejo C
12-0251-82 was used in Flow Cytometry to suggest a role for BMPs in early immune events that take place in myelin oligodendrocyte glycoprotein (MOG)-induced EAE.
Thu Oct 01 00:00:00 EDT 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
12-0251 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
12-0251 was used in Flow cytometry/Cell sorting to study the mechanism by which mesenchymal stem cells can treat steroid resistant acute graft-versus-host disease.
Wed Jan 01 00:00:00 EST 2020
A novel inhibitory role of microRNA-224 in particulate matter 2.5-induced asthmatic mice by inhibiting TLR2.
Journal of cellular and molecular medicine
Li P,Wang J,Guo F,Zheng B,Zhang X
12-0251-82 was used in Flow cytometry/Cell sorting to explore the effect of miR-224 on PM2.5-induced asthmatic mice.
Sun Mar 01 00:00:00 EST 2020
Interleukin-38 protects against sepsis by augmenting immunosuppressive activity of CD4+ CD25+ regulatory T cells.
Journal of cellular and molecular medicine
Ge Y,Huang M,Wu Y,Dong N,Yao YM
12-0251-82 was used in Flow Cytometry to investigate the role of IL-38 in mediating the activity of CD4+ CD25+ Tregs during sepsis.
Wed Jan 01 00:00:00 EST 2020
IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion.
Molecular medicine reports
Liu M,Li Z,Yao W,Zeng X,Wang L,Cheng J,Ma B,Zhang R,Min W,Wang H
12-0251-82 was used in Flow Cytometry to investigate whether an iindoleamine 2,3‚dioxygenase (IDO) inhibitor synergized with radiotherapy (RT) can further inhibit tumor growth.
Wed Jan 01 00:00:00 EST 2020
Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation.
Immunobiology
Jaiswal AK,Makhija S,Stahr N,Sandey M,Suryawanshi A,Mishra A
12-0251-82 was used in Flow Cytometry to support a model in which Alternaria sensitization in airways induce a circuitry of glycolysis and PKM2 regulation that confers an acute activation of APCs in the lung, whose targeting might represent a strategy for asthma treatment.
Wed Jul 01 00:00:00 EDT 2020
Regulation of T cell receptor signaling by protein acyltransferase DHHC21.
Molecular biology reports
Fan Y,Shayahati B,Tewari R,Boehning D,Akimzhanov AM
12-0251-82 was used in Flow Cytometry to investigate if DHHC protein acyltransferases can play an essential role in regulation of T cell-mediated immunity.
Sat Aug 01 00:00:00 EDT 2020
miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling.
Cell reports
Hines MJ,Coffre M,Mudianto T,Panduro M,Wigton EJ,Tegla C,Osorio-Vasquez V,Kageyama R,Benhamou D,Perez O,Bajwa S,McManus MT,Ansel KM,Melamed D,Koralov SB
12-0251 was used in Flow cytometry/Cell sorting to suggest a critical role for the miR-29-PTEN-PI3K regulatory axis in mature B lymphocytes.
Tue Dec 01 00:00:00 EST 2020
MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-Type-Specific Manner.
Cell reports
Cordeiro B,Jeon P,Boukhaled GM,Corrado M,Lapohos O,Roy DG,Williams K,Jones RG,Gruenheid S,Sagan SM,Krawczyk CM
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that miR-9 facilitates the transition of DCs from steady state to mature state by regulating the expression of several negative regulators of DC function in a cell-type-specific manner.
Tue May 05 00:00:00 EDT 2020
Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3+ Treg Cells by Multiparameter Flow Cytometry.
STAR protocols
Li C,Park JH
12-0251 was used in Flow cytometry/Cell sorting to reveal the cytokine responsiveness of individual T cells.
Fri Dec 18 00:00:00 EST 2020
Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.
Cell reports
Piao W,Xiong Y,Li L,Saxena V,Smith KD,Hippen KL,Paluskievicz C,Willsonshirkey M,Blazar BR,Abdi R,Bromberg JS
12-0251 was used in Flow cytometry/Cell sorting to demonstrate the role of regulatory T cells in enhancing leukocyte migration through endothelial barriers.
Tue Jan 28 00:00:00 EST 2020
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
12-0251-82 was used in Immunocytochemistry to examine immunomodulatory properties of potential probiotic strains in Crohn's disease and colitis.
Tue Mar 24 00:00:00 EDT 2020
Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer.
Journal for immunotherapy of cancer
Bai F,Zhang P,Fu Y,Chen H,Zhang M,Huang Q,Li D,Li B,Wu K
12-0251 was used in Flow cytometry/Cell sorting to show that ANXA1 expression is associated with lower survival and a higher risk of breast malignancy.
Wed Apr 01 00:00:00 EDT 2020
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
12-0251 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of two commercial multispecies probiotics-Lactibiane iki and Vivomixx-on the clinical outcome of established experimental autoimmune encephalomyelitis (EAE).
Tue Apr 07 00:00:00 EDT 2020
[Effect of Fei-Liu-Ping ointment combined with cyclophosphamide on lung cancer cell proliferation and acidic microenvironment].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Geng L,Lv J,Fan J
12-0251-82 was used in Flow Cytometry to observe the effects of Fei-Liu-Ping ointment and chemotherapy on mice with lung cancer, and to explore the inherent mechanism of action from the point of acidic microenvironment and apoptosis.
Sat Apr 18 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
12-0251 was used in Flow cytometry/Cell sorting to suggest a revised model for ILC differentiation that redefines the cell-fate potential of helper-ILC-restricted Zbtb16+ ILCPs.
Tue Apr 16 00:00:00 EDT 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
12-0251 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
The Journal of clinical investigation
Yamamoto A,Hester J,Macklin PS,Kawai K,Uchiyama M,Biggs D,Bishop T,Bull K,Cheng X,Cawthorne E,Coleman ML,Crockford TL,Davies B,Dow LE,Goldin R,Kranc K,Kudo H,Lawson H,McAuliffe J,Milward K,Scudamore CL,Soilleux E,Issa F,Ratcliffe PJ,Pugh CW
12-0251-82 was used in Functional assay to study the effect of stabilizing HIF levels in adult mice through PHD2 enzyme silencing on multi-lineage leukocytosis and features of autoimmunity.
Tue Jun 04 00:00:00 EDT 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
12-0251-82 was used in Flow Cytometry to performed immunophenotypic analysis of bone marrow cells and splenocytes from both genders of three commonly used murine strains (C57BL/6NCr, 129/SvHsd, and BALB/cAnNCr).
Tue Jan 01 00:00:00 EST 2019
T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling.
Advances in wound care
Wang X,Balaji S,Steen EH,Li H,Rae MM,Blum AJ,Miao Q,Butte MJ,Bollyky PL,Keswani SG
12-0251-82 was used in Flow Cytometry to implicate adaptive immunity in the regulation of scarring phenotypes.
Fri Nov 01 00:00:00 EDT 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
12-0251 was used in Flow cytometry/Cell sorting to investigate the antitumor and immunomodulatory effects of CS2164.
Tue Oct 01 00:00:00 EDT 2019
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
12-0251 was used in Flow cytometry/Cell sorting to investigate the underlying sex differences that may contribute to differential footpad delayed-type hypersensitivity responses using wildtype and four core genotypes mice and popliteal lymphnode cellularity and gene expression.
Wed Jan 30 00:00:00 EST 2019
Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation.
Frontiers in immunology
Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K
12-0251 was used in Flow cytometry/Cell sorting to investigate the specific function α7 nAChRs on T cells and antigen presenting cells (APCs) in mice.
Fri Aug 21 00:00:00 EDT 2020
Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.
Scientific reports
Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM
12-0251-82 was used in Flow Cytometry to demonstrate a novel role for TNAP activity in shaping the dynamic interactions within the brain-immune axis.
Wed Dec 11 00:00:00 EST 2019
SCGN deficiency results in colitis susceptibility.
eLife
Sifuentes-Dominguez LF,Li H,Llano E,Liu Z,Singla A,Patel AS,Kathania M,Khoury A,Norris N,Rios JJ,Starokadomskyy P,Park JY,Gopal P,Liu Q,Tan S,Chan L,Ross T,Harrison S,Venuprasad K,Baker LA,Jia D,Burstein E
12-0251-82 was used in Flow cytometry/Cell sorting to report the identification of an ultra rare missense variant (NM_006998.3:c.230G > A;p.Arg77His) in the SCGN gene causing Mendelian early-onset ulcerative colitis.
Wed Oct 30 00:00:00 EDT 2019
The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.
Frontiers in pharmacology
Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK
12-0251 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.
Wed Sep 30 00:00:00 EDT 2020
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
12-0251-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Glucose lowering by SGLT2-inhibitor empagliflozin accelerates atherosclerosis regression in hyperglycemic STZ-diabetic mice.
Scientific reports
Pennig J,Scherrer P,Gissler MC,Anto-Michel N,Hoppe N,Füner L,Härdtner C,Stachon P,Wolf D,Hilgendorf I,Mullick A,Bode C,Zirlik A,Goldberg IJ,Willecke F
12-0251-82 was used in Flow Cytometry to determine whether glucose lowering by empagliflozin accelerates atherosclerosis regression in a mouse model.
Fri Nov 29 00:00:00 EST 2019
Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells.
Immunity
Hu G,Cui K,Fang D,Hirose S,Wang X,Wangsa D,Jin W,Ried T,Liu P,Zhu J,Rothenberg EV,Zhao K
12-0251 was used in Flow cytometry/Cell sorting to find that abrupt genome-wide changes at all three levels of chromatin organization occur during the transition from double-negative stage 2 (DN2) to DN3, accompanying the T lineage commitment.
Tue Feb 20 00:00:00 EST 2018
RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.
Immunity
Wu B,Zhang S,Guo Z,Wang G,Zhang G,Xie L,Lou J,Chen X,Wu D,Bergmeier W,Zheng J,Wan YY
12-0251 was used in Flow cytometry/Cell sorting to indicate that a distinct molecular program directs pTh17 cell generation and reveals targets for treating pTh17 cell-related pathology and diseases.
Tue Nov 20 00:00:00 EST 2018
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
12-0251 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.
Mon Aug 13 00:00:00 EDT 2018
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A
12-0251 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.
Tue May 15 00:00:00 EDT 2018
Regulatory T-Cells Mediate IFN-α-Induced Resistance against Antigen-Induced Arthritis.
Frontiers in immunology
Chenna Narendra S,Chalise JP,Biggs S,Kalinke U,Magnusson M
Mon Apr 08 00:00:00 EDT 2019
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
12-0251-82 was used in Flow Cytometry to study the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioural and pathological outcomes in Alzheimer's disease.
Fri Jun 15 00:00:00 EDT 2018
Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice.
Experimental and therapeutic medicine
Masuda J,Takayama E,Ichinohe T,Strober W,Mizuno-Kamiya M,Ikawa T,Kitani A,Kawaki H,Fuss I,Kawamoto H,Seno A,Vaidyanath A,Umemura N,Mizutani A,Kasai T,Honjo Y,Satoh A,Murakami H,Katsura Y,Kondoh N,Seno M
12-0251 was used in Flow cytometry/Cell sorting to study the mechanism of immunosuppression by mesenchymal stem cells, in particular those derived from adipose tissue.
Thu Nov 01 00:00:00 EDT 2018
SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.
Nature communications
Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K
12-0251 was used in Flow cytometry/Cell sorting to define the molecular mechanisms that govern the transcription factor activity of ROR-γt in the regulation of IL-17.
Tue Oct 30 00:00:00 EDT 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
12-0251 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling.
Nature communications
Piao W,Xiong Y,Famulski K,Brinkman CC,Li L,Toney N,Wagner C,Saxena V,Simon T,Bromberg JS
12-0251 was used in Flow cytometry/Cell sorting to demonstrate the importance of LTΒR signaling in leukocyte migration and LEC and lymphatic vessel function, and show that antagonist peptides may serve as lead compounds for therapeutic applications.
Wed Aug 01 00:00:00 EDT 2018
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.
Cell host & microbe
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri B
12-0251-82 was used in Flow cytometry/Cell sorting to show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen.
Wed Nov 14 00:00:00 EST 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
12-0251 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
Immunity, inflammation and disease
Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P
12-0251 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.
Fri Jun 01 00:00:00 EDT 2018
CD9+ Regulatory B Cells Induce T Cell Apoptosis via IL-10 and Are Reduced in Severe Asthmatic Patients.
Frontiers in immunology
Brosseau C,Durand M,Colas L,Durand E,Foureau A,Cheminant MA,Bouchaud G,Castan L,Klein M,Magnan A,Brouard S
12-0251 was used in Flow cytometry/Cell sorting to study CD9+ B cell defects in causing lack of regulation of inflammation in patients with severe asthma.
Fri Oct 25 00:00:00 EDT 2019
IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection.
Cell reports
Fabié A,Mai LT,Dagenais-Lussier X,Hammami A,van Grevenynghe J,Stäger S
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that IRF-5 is increasingly expressed in interferon (IFN)-γ+ CD4 T cells over the course of L. donovani infection.
Tue Jul 31 00:00:00 EDT 2018
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Nature
Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR
Thu Sep 28 00:00:00 EDT 2017
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Immunity
Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that glucokinase-dependent glycolysis regulates regulatory T cell migration.
Tue Nov 21 00:00:00 EST 2017
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Immunity
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH
12-0251-82 was used in Flow Cytometry to investigate how different subtypes of T cell antigen-presenting cell contribute to determining viral set point and disease outcome.
Tue Nov 21 00:00:00 EST 2017
CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.
Molecular cell
Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K
Thu Sep 21 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
12-0251 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.
Mon Jun 05 00:00:00 EDT 2017
Erythropoietin Receptor-Mediated Molecular Crosstalk Promotes T Cell Immunoregulation and Transplant Survival.
Journal of the American Society of Nephrology : JASN
Purroy C,Fairchild RL,Tanaka T,Baldwin WM,Manrique J,Madsen JC,Colvin RB,Alessandrini A,Blazar BR,Fribourg M,Donadei C,Maggiore U,Heeger PS,Cravedi P
12-0251 was used in Flow cytometry/Cell sorting to delineate the protolerogenic properties of EPO in inhibiting conventional T cells while simultaneously promoting Treg induction.
Tue Aug 01 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
12-0251-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
12-0251 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells.
Frontiers in immunology
Zayoud M,Marcu-Malina V,Vax E,Jacob-Hirsch J,Elad-Sfadia G,Barshack I,Kloog Y,Goldstein I
12-0251 was used in Flow cytometry/Cell sorting to test the therapeutic and immunomodulatory effects of farnesylthiosalicylic acid and its derivative 5-fluoro-FTS in the rat adjuvant-induced arthritis model.
Wed Nov 20 00:00:00 EST 2019
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Oncogene
Sochalska M,Schuler F,Weiss JG,Prchal-Murphy M,Sexl V,Villunger A
12-0251 was used in Flow cytometry/Cell sorting to analyse the role of the anti-apoptotic protein, BCL2A1/A1, in blood cancers driven by either the MYC or ABL kinases.
Sat Apr 01 00:00:00 EDT 2017
Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy.
International journal of cancer
Santos JM,Havunen R,Siurala M,Cervera-Carrascon V,Tähtinen S,Sorsa S,Anttila M,Karell P,Kanerva A,Hemminki A
12-0251 was used in Flow cytometry/Cell sorting to study the efficacy and safety of intratumorally administered IL-2 coding adenoviruses in combination with lymphocyte therapy in Syrian hamsters bearing pancreatic tumours.
Sun Oct 01 00:00:00 EDT 2017
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Immunology
Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.
Mon May 01 00:00:00 EDT 2017
The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
Immunology
Gonçalves AC,Ferreira LS,Manente FA,de Faria CMQG,Polesi MC,de Andrade CR,Zamboni DS,Carlos IZ
Thu Jun 01 00:00:00 EDT 2017
Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Strandt H,Pinheiro DF,Kaplan DH,Wirth D,Gratz IK,Hammerl P,Thalhamer J,Stoecklinger A
12-0251 was used in Flow cytometry/Cell sorting to study the function of Langerhans cells in vivo, without altering the dendritic cell subset composition in the skin.
Fri Sep 01 00:00:00 EDT 2017
The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW
12-0251 was used in Flow cytometry/Cell sorting to support the hypothesis that the Ox40/Ox40L pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1.
Tue Aug 15 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
12-0251 was used in Flow cytometry/Cell sorting to suggest that IL-2C treatment can alleviate inflammation and maintain blood vessel stability after traumatic brain injury.
Thu Oct 01 00:00:00 EDT 2020
ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells.
Molecular medicine reports
Zhou H,Wang L,Xu Q,Liu Q,Liu H,Qiu W,Hu T,Lv Y,Zhang Q
Fri Dec 01 00:00:00 EST 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
12025182 was used in flow cytometry to assess if aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts
Fri Jan 06 00:00:00 EST 2017
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.
Oncoimmunology
Lewis KE,Selby MJ,Masters G,Valle J,Dito G,Curtis WR,Garcia R,Mink KA,Waggie KS,Holdren MS,Grosso JF,Korman AJ,Jure-Kunkel M,Dillon SR
12-0251 was used in Flow cytometry/Cell sorting to investigate the efficacy of immune-modulatory interleukin-21 combined with checkpoint blockade in several syngeneic mouse tumor models.
Tue Jan 12 00:00:00 EST 2021
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
12-0251 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.
Mon Feb 06 00:00:00 EST 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
12-0251 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 EDT 2022
Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade.
Oncoimmunology
Secondini C,Coquoz O,Spagnuolo L,Spinetti T,Peyvandi S,Ciarloni L,Botta F,Bourquin C,Rüegg C
12-0251 was used in Flow cytometry/Cell sorting to investigate the effect of VEGF/VEGFR-2 axis inhibition on lung metastasis, myeloid-derived suppressor cells and regulatory T cells.
Tue Jan 12 00:00:00 EST 2021
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
12-0251 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.
Thu Aug 24 00:00:00 EDT 2017
Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter.
Respiratory research
Jaligama S,Saravia J,You D,Yadav N,Lee GI,Shrestha B,Cormier SA
Fri Jan 13 00:00:00 EST 2017
Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models.
Scientific reports
Chen CY,Wang PY,Hutzen B,Sprague L,Swain HM,Love JK,Stanek JR,Boon L,Conner J,Cripe TP
12-0251 was used in Flow cytometry/Cell sorting to show the combination of PD-1 blockade and oHSV-1 may be an effective treatment strategy for childhood soft tissue sarcoma.
Wed May 24 00:00:00 EDT 2017
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.
The Journal of experimental medicine
Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D
12-0251 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.
Mon Sep 19 00:00:00 EDT 2016
The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses.
Frontiers in immunology
Akhmatova NK,Kurbatova EA,Akhmatov EA,Egorova NB,Logunov DY,Gening ML,Sukhova EV,Yashunsky DV,Tsvetkov YE,Nifantiev NE
12-0251 was used in Flow cytometry/Cell sorting to evaluate the effects of immunisation with a synthetic hexasaccharide conjugate, with and without an adjuvant, on TLR activation, dendritic cell maturation, and cytokine production in mice.
Fri Jul 22 00:00:00 EDT 2016
Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.
Mucosal immunology
Gold MJ,Hiebert PR,Park HY,Stefanowicz D,Le A,Starkey MR,Deane A,Brown AC,Liu G,Horvat JC,Ibrahim ZA,Sukkar MB,Hansbro PM,Carlsten C,VanEeden S,Sin DD,McNagny KM,Knight DA,Hirota JA
12-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms governing induction of innate immune responses and allergic sensitisation by particulate matter.
Sun May 01 00:00:00 EDT 2016
The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population.
Journal of immunology (Baltimore, Md. : 1950)
Ju X,Silveira PA,Hsu WH,Elgundi Z,Alingcastre R,Verma ND,Fromm PD,Hsu JL,Bryant C,Li Z,Kupresanin F,Lo TH,Clarke C,Lee K,McGuire H,Fazekas de St Groth B,Larsen SR,Gibson J,Bradstock KF,Clark GJ,Hart DN
12025182 was used in flow cytometry to determine which cells express CD83
Thu Dec 15 00:00:00 EST 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
12-0251 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
Helios Controls a Limited Subset of Regulatory T Cell Functions.
Journal of immunology (Baltimore, Md. : 1950)
Sebastian M,Lopez-Ocasio M,Metidji A,Rieder SA,Shevach EM,Thornton AM
12-0251 was used in Flow cytometry/Cell sorting to determine the beneficial effects of the transcription factor, Helios, for Treg maintenance, differentiation, and survival.
Fri Jan 01 00:00:00 EST 2016
IKKβ-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1/Th17 cell activation and compromising blood brain barrier.
Molecular neurodegeneration
Lee MJ,Bing SJ,Choi J,Jang M,Lee G,Lee H,Chang BS,Jee Y,Lee SJ,Cho IH
12-0251 was used in Flow cytometry/Cell sorting to suggest that IKK/NF-kB-induced myeloid cell activation exacerbates experimental autoimmune encephalomyelitis through activating Th1 and Th17 responses and weakening the blood brain barrier.
Fri Jul 22 00:00:00 EDT 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
12-0251 was used in Magnetic cell separation to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Thu Mar 03 00:00:00 EST 2016
The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.
PloS one
Braun J,Meixner A,Brachner A,Foisner R
12-0251 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.
Fri Aug 12 00:00:00 EDT 2016
IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.
PloS one
Put K,Brisse E,Avau A,Imbrechts M,Mitera T,Janssens R,Proost P,Fallarino F,Wouters CH,Matthys P
12-0251 was used in Flow cytometry/Cell sorting to unravel the role of IDO1, an immune-modulatory enzyme, in the pathogenesis of certain inflammatory diseases.
Mon Aug 08 00:00:00 EDT 2016
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nature communications
Meininger I,Griesbach RA,Hu D,Gehring T,Seeholzer T,Bertossi A,Kranich J,Oeckinghaus A,Eitelhuber AC,Greczmiel U,Gewies A,Schmidt-Supprian M,Ruland J,Brocker T,Heissmeyer V,Heyd F,Krappmann D
12-0251 was used in Flow cytometry/Cell sorting to study how TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
Tue Apr 12 00:00:00 EDT 2016
Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells.
Scientific reports
do Canto FB,Campos SM,Granato A,da Silva RF,de Paiva LS,Nóbrega A,Bellio M,Fucs R
12-0251 was used in Flow cytometry/Cell sorting to show that augmentation of naïve T cell numbers in the inoculum of RAG KO mice suppresses colon disease and promotes immune homeostasis.
Wed Jun 29 00:00:00 EDT 2016
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
The Journal of clinical investigation
Millet A,Martin KR,Bonnefoy F,Saas P,Mocek J,Alkan M,Terrier B,Kerstein A,Tamassia N,Satyanarayanan SK,Ariel A,Ribeil JA,Guillevin L,Cassatella MA,Mueller A,Thieblemont N,Lamprecht P,Mouthon L,Perruche S,Witko-Sarsat V
12-0251 was used in Flow cytometry/Cell sorting to investigate disruption of immune silencing by proteinase 3 on apoptotic cells.
Mon Nov 02 00:00:00 EST 2015
IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.
Journal of immunology (Baltimore, Md. : 1950)
Otero DC,Fares-Frederickson NJ,Xiao M,Baker DP,David M
12-0251 was used in Flow cytometry/Cell sorting to investigate the mechanism by which interferon beta limits T cell responses and its potential therapeutic use for multiple sclerosis.
Mon Jun 01 00:00:00 EDT 2015
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NI,Cowan JE,Nakamura K,Bacon A,Baik S,White AJ,Parnell SM,Jenkinson EJ,Jenkinson WE,Anderson G
12-0251 was used in Flow cytometry/Cell sorting to elucidate the conditions controlling medullary thymic epithelial cell (mTEC) homeostasis and the production of mTEC-dependent Foxp3(+) Tregs.
Tue Sep 15 00:00:00 EDT 2015
Aryl Hydrocarbon Receptor Protects Lungs from Cockroach Allergen-Induced Inflammation by Modulating Mesenchymal Stem Cells.
Journal of immunology (Baltimore, Md. : 1950)
Xu T,Zhou Y,Qiu L,Do DC,Zhao Y,Cui Z,Wang H,Liu X,Saradna A,Cao X,Wan M,Gao P
12-0251 was used in Flow cytometry/Cell sorting to investigate whether AhR can sense cockroach allergens and modulate allergen-induced lung inflammation, showing that it protects from inflammation by modulating MSCs.
Tue Dec 15 00:00:00 EST 2015
MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.
Journal of immunology (Baltimore, Md. : 1950)
Singh Y,Garden OA,Lang F,Cobb BS
12-0251 was used in Flow cytometry/Cell sorting to understand miRNA function in Treg development..
Tue Dec 15 00:00:00 EST 2015
A noninflammatory immune response in aged DNA Aβ42-immunized mice supports its safety for possible use as immunotherapy in AD patients.
Neurobiology of aging
Lambracht-Washington D,Rosenberg RN
12-0251 was used in Immunofluorescence to compare anti-Aβ42 antibody levels in mice after different immunisation approaches and doses.
Sun Mar 01 00:00:00 EST 2015
Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via interleukin 10 and downregulates Th1 effector cells.
Infection and immunity
Ruiz Díaz P,Mucci J,Meira MA,Bogliotti Y,Musikant D,Leguizamón MS,Campetella O
12-0251 was used in Flow cytometry/Cell sorting to identify the interferons and interleukins released by immune cells in response to Trypanosoma cruzi infection.
Fri May 01 00:00:00 EDT 2015
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
12-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 EST 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
12-0251 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.
Oncoimmunology
Du Four S,Maenhout SK,De Pierre K,Renmans D,Niclou SP,Thielemans K,Neyns B,Aerts JL
12-0251 was used in Flow cytometry/Cell sorting to study the increased infiltration of immune cells and reduced suppressive capacity of monocytic MDSCs following Axitinib dosing in an intracranial mouse melanoma model.
Wed Apr 01 00:00:00 EDT 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 EST 2015
Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets.
Oncotarget
Ehx G,Hannon M,Beguin Y,Humblet-Baron S,Baron F
12-0251 was used in Flow cytometry/Cell sorting to evaluate a novel staining method with the potential to monitor the responses of various Treg subsets to IL-2 therapy.
Tue Dec 22 00:00:00 EST 2015
Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.
PloS one
Yong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH
12-0251 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter.
Wed Jun 08 00:00:00 EDT 2016
Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice.
Scientific reports
Singh K,Hjort M,Thorvaldson L,Sandler S
12-0251 was used in Flow cytometry/Cell sorting to investigate the use of Helios and Nrp1 as markers for thymic-derived Tregs, showing that Helios may be a more reliable marker than Nrp1.
Wed Jan 14 00:00:00 EST 2015
An Oriental Medicine, Hyungbangpaedok-San Attenuates Motor Paralysis in an Experimental Model of Multiple Sclerosis by Regulating the T Cell Response.
PloS one
Choi JH,Lee MJ,Jang M,Kim EJ,Shim I,Kim HJ,Lee S,Lee SW,Kim YO,Cho IH
12-0251 was used in Flow cytometry/Cell sorting to investigate the beneficial effects of Hyungbangpaedok-san treatment in experimental autoimmune encephalomyelitis mice immunized with myelin oligodendrocyte glycoprotein peptide.
Wed Jun 01 00:00:00 EDT 2016
Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
Nature immunology
Au-Yeung BB,Melichar HJ,Ross JO,Cheng DA,Zikherman J,Shokat KM,Robey EA,Weiss A
12-0251 was used in Flow cytometry/Cell sorting to show that CD4(+)CD8(+) thymocytes integrate multiple, transient, Zap70-dependent signals over more than 36 h to reach a cumulative threshold for positive selection.
Tue Jul 01 00:00:00 EDT 2014
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
12-0251 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice.
Arthritis & rheumatology (Hoboken, N.J.)
Ding Y,Li J,Yang P,Luo B,Wu Q,Zajac AJ,Wildner O,Hsu HC,Mountz JD
12-0251 was used in Flow cytometry/Cell sorting to indicate that high levels of IL-21 selectively enhance Tfh cell differentiation but inhibit Tfr cell commitment and the suppressive function of Tfr cells on Tfh cells and B cells.
Mon Sep 01 00:00:00 EDT 2014
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.
The Journal of allergy and clinical immunology
Gold MJ,Antignano F,Halim TY,Hirota JA,Blanchet MR,Zaph C,Takei F,McNagny KM
12-0251 was used in Flow cytometry/Cell sorting to reveal a critical role for ILC2s in the development of adaptive type 2 responses to local antigen exposure.
Tue Apr 01 00:00:00 EDT 2014
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.
eLife
Baptista AP,Roozendaal R,Reijmers RM,Koning JJ,Unger WW,Greuter M,Keuning ED,Molenaar R,Goverse G,Sneeboer MM,den Haan JM,Boes M,Mebius RE
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of MHC-II in lymph node stromal cells, showing that stromal cells constrain immunity through MHC-II expression.
Wed Nov 19 00:00:00 EST 2014
Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo.
Journal of leukocyte biology
Rojo JM,Ojeda G,Acosta YY,Montes-Casado M,Criado G,Portolés P
12-0251 was used in Flow cytometry/Cell sorting to show that TCR/CD3 complexes in CD4(+)CD25(+)Foxp3(+) Tregs differ quantitatively and qualitatively from the rest of the CD4(+) population.
Sat Mar 01 00:00:00 EST 2014
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Journal of leukocyte biology
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
12-0251 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.
Sat Nov 01 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
12-0251 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Fujiwara H,Maeda Y,Kobayashi K,Nishimori H,Matsuoka K,Fujii N,Kondo E,Tanaka T,Chen L,Azuma M,Yagita H,Tanimoto M
12-0251 was used in Flow cytometry/Cell sorting to clarify that programed death-ligand 1 deficiency in host tissues, not hematopoietic cells, is associated with exacerbated chronic graft-versus-host disease.
Mon Sep 01 00:00:00 EDT 2014
Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Mercadante AC,Perobelli SM,Alves AP,Gonçalves-Silva T,Mello W,Gomes-Santos AC,Miyoshi A,Azevedo V,Faria AM,Bonomo A
12-0251 was used in Flow cytometry/Cell sorting to suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of graft-versus-leukemia in allogenic HSCT.
Sat Feb 15 00:00:00 EST 2014
Functional effects of TGF-β1 on mesenchymal stem cell mobilization in cockroach allergen-induced asthma.
Journal of immunology (Baltimore, Md. : 1950)
Gao P,Zhou Y,Xian L,Li C,Xu T,Plunkett B,Huang SK,Wan M,Cao X
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of TGF-β1 in mesenchymal stem cell migration in allergic asthma.
Thu May 15 00:00:00 EDT 2014
Autoimmune vitiligo does not require the ongoing priming of naive CD8 T cells for disease progression or associated protection against melanoma.
Journal of immunology (Baltimore, Md. : 1950)
Byrne KT,Zhang P,Steinberg SM,Turk MJ
12-0251 was used in Flow Cytometry to demonstrate that ongoing CD8 T-cell-mediated autoimmune vitiligo is a weakly immunogenic event perpetuated by long-lived T-cells.
Sat Feb 15 00:00:00 EST 2014
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.
Journal of immunology (Baltimore, Md. : 1950)
Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
12-0251 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.
Fri Aug 01 00:00:00 EDT 2014
The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Marquet M,Garot A,Bender S,Carrion C,Rouaud P,Lecardeur S,Denizot Y,Cogné M,Pinaud E
12-0251 was used in Flow cytometry/Cell sorting to study the VH gene repertoire and IgH expression in developing B-lineage cells.
Fri Aug 01 00:00:00 EDT 2014
Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection.
Particle and fibre toxicology
Lee GI,Saravia J,You D,Shrestha B,Jaligama S,Hebert VY,Dugas TR,Cormier SA
12-0251 was used in Flow cytometry/Cell sorting to study how EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.
Thu Oct 30 00:00:00 EDT 2014
Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.
Nature communications
Lin CC,Bradstreet TR,Schwarzkopf EA,Sim J,Carrero JA,Chou C,Cook LE,Egawa T,Taneja R,Murphy TL,Russell JH,Edelson BT
12-0251 was used in Flow cytometry/Cell sorting to study the factors affecting pathogenicity of TH cells in experimental autoimmune encephalomyelitis (EAE), showing that Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in EAE.
Thu Apr 03 00:00:00 EDT 2014
Synergic silencing of costimulatory molecules prevents cardiac allograft rejection.
Journal of translational medicine
Zhang X,Liu Y,Zhang G,Shi J,Zhang X,Zheng X,Jiang AT,Zhang ZX,Johnston N,Siu KS,Chen R,Lian D,Koos D,Quan D,Min WP
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that the simultaneous silencing of CD40 and CD80 prevents allograft rejection.
Thu May 22 00:00:00 EDT 2014
Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions.
PloS one
Khattar M,Miyahara Y,Schroder PM,Xie A,Chen W,Stepkowski SM
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of IL-2 during early events of T cell activation, showing that IL-21 is a critical regulator of T cell survival during priming under IL-2 deprivation.
Mon Sep 08 00:00:00 EDT 2014
Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells.
Blood
Pasquet L,Douet JY,Sparwasser T,Romagnoli P,van Meerwijk JP
12-0251 was used in Flow cytometry/Cell sorting to assess if persistence of administered regulatory T cells is required for long-term maintenance of tolerance to allografts.
Thu May 23 00:00:00 EDT 2013
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
The Journal of experimental medicine
Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
12-0251 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.
Mon Apr 08 00:00:00 EDT 2013
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Goto R,You S,Zaitsu M,Chatenoud L,Wood KJ
12-0251 was used in Flow cytometry/Cell sorting to investigate the result of delayed anti-CD3 therapy on the number and dominance of alloreactive/graft infiltrating cells.
Mon Jul 01 00:00:00 EDT 2013
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice.
European journal of immunology
Yu Y,Wang D,Kaosaard K,Liu C,Fu J,Haarberg K,Anasetti C,Beg AA,Yu XZ
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of c-Rel in transplant tolerance and graft-versus-host disease (GVHD), showing that it is an essential transcription factor for the development of acute GVHD.
Sun Sep 01 00:00:00 EDT 2013
Sox4 is required for the survival of pro-B cells.
Journal of immunology (Baltimore, Md. : 1950)
Sun B,Mallampati S,Gong Y,Wang D,Lefebvre V,Sun X
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of Sox4 in development of mature B cells, showing that it is required for pro-B cell survival.
Fri Mar 01 00:00:00 EST 2013
Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis.
Carcinogenesis
Chopra M,Riedel SS,Biehl M,Krieger S,von Krosigk V,Bäuerlein CA,Brede C,Jordan Garrote AL,Kraus S,Schäfer V,Ritz M,Mattenheimer K,Degla A,Mottok A,Einsele H,Wajant H,Beilhack A
12-0251 was used in Flow cytometry/Cell sorting to reveal a novel role for TNF and its receptor, TNFR2, in the progression of metastasis in a melanoma mouse model of lung metastasis.
Sat Jun 01 00:00:00 EDT 2013
The crosstalk: Tumor-infiltrating lymphocytes rich in regulatory T cells suppressed cancer-associated fibroblasts.
Acta oncologica (Stockholm, Sweden)
Fu Z,Zuo Y,Li D,Xu W,Li D,Chen H,Zheng S
12-0251 was used in Flow cytometry/Cell sorting to investigate the suppression of CAFs and NFs by Tregs-rich TILs.
Fri Nov 01 00:00:00 EDT 2013
Ontogeny and localization of the cells produce IL-2 in healthy animals.
Cytokine
Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M
12-0251 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..
Fri Mar 01 00:00:00 EST 2013
Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses.
PloS one
Medeiros MM,da Silva HB,Reis AS,Barboza R,Thompson J,Lima MR,Marinho CR,Tadokoro CE
12-0251 was used in Flow cytometry/Cell sorting to determine that malaria parasite accumulation could be an escape mechanism to avoid sterile immunity sponsored by a tolerogenic environment.
Wed Dec 17 00:00:00 EST 2014
Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.
PloS one
Chopra M,Lang I,Salzmann S,Pachel C,Kraus S,Bäuerlein CA,Brede C,Garrote AL,Mattenheimer K,Ritz M,Schwinn S,Graf C,Schäfer V,Frantz S,Einsele H,Wajant H,Beilhack A
12-0251 was used in Flow cytometry/Cell sorting to assess the mechanisms underlying the contribution of tumour necrosis factor to carcinogenesis.
Mon May 12 00:00:00 EDT 2014
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
12-0251 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
Suppression of autoimmune retinal inflammation by an antiangiogenic drug.
PloS one
Yoshimura T,Benny O,Bazinet L,D'Amato RJ
12-0251 was used in Flow cytometry/Cell sorting to discover that Lodamin suppresses T cell receptor mediated T cell proliferation and reduces the production of Th1 and Th17 cells.
Tue Jan 21 00:00:00 EST 2014
Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.
Blood
Savino B,Castor MG,Caronni N,Sarukhan A,Anselmo A,Buracchi C,Benvenuti F,Pinho V,Teixeira MM,Mantovani A,Locati M,Bonecchi R
12-0251 was used in Flow cytometry/Cell sorting to study how control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
Thu May 31 00:00:00 EDT 2012
Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.
Cellular & molecular immunology
Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y
12-0251 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.
Sun Jan 01 00:00:00 EST 2012
Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury.
The Journal of clinical investigation
Li L,Huang L,Ye H,Song SP,Bajwa A,Lee SJ,Moser EK,Jaworska K,Kinsey GR,Day YJ,Linden J,Lobo PI,Rosin DL,Okusa MD
12-0251 was used in Flow cytometry/Cell sorting to show that mice with A2AR-deficient dendritic cells are more susceptible to kidney ischemia/reperfusion injury.
Thu Nov 01 00:00:00 EDT 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
12-0251 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
The Journal of experimental medicine
Yokosuka T,Takamatsu M,Kobayashi-Imanishi W,Hashimoto-Tane A,Azuma M,Saito T
12-0251 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of PD-1-mediated suppression of T cell activation, showing that it inhibits T cell receptor signalling via SHP2.
Mon Jun 04 00:00:00 EDT 2012
Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells.
Cancer research
Tang S,Moore ML,Grayson JM,Dubey P
12-0251 was used in Flow cytometry/Cell sorting to evaluate the effects of concomitant castration and immunisation on T cell function in mice.
Sun Apr 15 00:00:00 EDT 2012
Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist.
Immunology and cell biology
Walker KM,Rytelewski M,Mazzuca DM,Meilleur SA,Mannik LA,Yue D,Brintnell WC,Welch I,Cairns E,Haeryfar SM
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that treatment with a Th2-skewing iNKT cell agonist prevents citrulline-induced autoimmune arthritis.
Sun Jul 01 00:00:00 EDT 2012
Splenic morphological changes are accompanied by altered baseline immunity in a mouse model of sickle-cell disease.
The American journal of pathology
Szczepanek SM,McNamara JT,Secor ER,Natarajan P,Guernsey LA,Miller LA,Ballesteros E,Jellison E,Thrall RS,Andemariam B
12-0251 was used in Flow cytometry/Cell sorting to investigate the relationship between functional asplenia from infarctions and increased infectious mortality in a mouse model of sickle-cell disease.
Thu Nov 01 00:00:00 EDT 2012
Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.
Journal of immunology (Baltimore, Md. : 1950)
Panzer M,Sitte S,Wirth S,Drexler I,Sparwasser T,Voehringer D
12-0251 was used in Flow cytometry/Cell sorting to determine whether different classes of T cells can be converted into IL-4-expressing Th2 cells in vivo by infection of mice with gastrointestinal helminth.
Sun Jan 15 00:00:00 EST 2012
Arsenic trioxide exerts antitumor activity through regulatory T cell depletion mediated by oxidative stress in a murine model of colon cancer.
Journal of immunology (Baltimore, Md. : 1950)
Thomas-Schoemann A,Batteux F,Mongaret C,Nicco C,Chéreau C,Annereau M,Dauphin A,Goldwasser F,Weill B,Lemare F,Alexandre J
12-0251 was used in Flow cytometry/Cell sorting to examine the potential for As(2)O(3) to enhance adoptive immunotherapy strategies in human cancer.
Sat Dec 01 00:00:00 EST 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
12-0251 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
CD5-dependent CK2 activation pathway regulates threshold for T cell anergy.
Journal of immunology (Baltimore, Md. : 1950)
Sestero CM,McGuire DJ,De Sarno P,Brantley EC,Soldevila G,Axtell RC,Raman C
12-0251 was used in Flow cytometry/Cell sorting to determine the physiological significance of CD5-dependent casein kinase 2 activation in T cells.
Sat Sep 15 00:00:00 EDT 2012
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
PloS one
Madireddi S,Schabowsky RH,Srivastava AK,Sharma RK,Yolcu ES,Shirwan H
12-0251 was used in Flow cytometry/Cell sorting to investigate whether 4-1BBL can prevent the conversion of effector CD4+ cells into induced T regulatory cells in tumour settings.
Tue Feb 19 00:00:00 EST 2013
Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson's disease.
Journal of neuroinflammation
St-Amour I,Bousquet M,Paré I,Drouin-Ouellet J,Cicchetti F,Bazin R,Calon F
12-0251 was used in Flow cytometry/Cell sorting to investigate the potential neurorestorative effect of IVIg treatment in mice.
Tue Oct 09 00:00:00 EDT 2012
Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.
PloS one
Simonetta F,Gestermann N,Martinet KZ,Boniotto M,Tissières P,Seddon B,Bourgeois C
12-0251 was used in Flow cytometry/Cell sorting to elucidate the mechanisms governing Treg cell survival and homeostasis.
Wed Sep 26 00:00:00 EDT 2012
Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.
PloS one
Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.
Tue Jun 11 00:00:00 EDT 2013
Pharyngeal microflora disruption by antibiotics promotes airway hyperresponsiveness after respiratory syncytial virus infection.
PloS one
Ni K,Li S,Xia Q,Zang N,Deng Y,Xie X,Luo Z,Luo Y,Wang L,Fu Z,Liu E
12-0251 was used in Flow cytometry/Cell sorting to demonstrate that antibiotic treatment clears pharyngeal commensal bacteria and depletes levels of pulmonary Tregs.
Wed Nov 28 00:00:00 EST 2012
Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice.
PloS one
Baru AM,Untucht C,Ganesh V,Hesse C,Mayer CT,Sparwasser T
12-0251 was used in Flow cytometry/Cell sorting to define culture conditions for efficient generation of eGFP(+)Foxp3(+) iTregs by use of DEREG mice.
Thu Feb 14 00:00:00 EST 2013
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Nature immunology
Motomura Y,Kitamura H,Hijikata A,Matsunaga Y,Matsumoto K,Inoue H,Atarashi K,Hori S,Watarai H,Zhu J,Taniguchi M,Kubo M
12-0251-82 was used in Flow cytometry/Cell sorting to indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in Th1 cells, and IL-10 in Th1, Th2, Treg and NKT cells.
Sun May 01 00:00:00 EDT 2011
Centrosome docking at the immunological synapse is controlled by Lck signaling.
The Journal of cell biology
Tsun A,Qureshi I,Stinchcombe JC,Jenkins MR,de la Roche M,Kleczkowska J,Zamoyska R,Griffiths GM
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of Lck signalling in the control of centrosome docking at the immunological synapse.
Mon Feb 21 00:00:00 EST 2011
A role for IL-27 in limiting T regulatory cell populations.
Journal of immunology (Baltimore, Md. : 1950)
Wojno ED,Hosken N,Stumhofer JS,O'Hara AC,Mauldin E,Fang Q,Turka LA,Levin SD,Hunter CA
12-0251 was used in Flow cytometry/Cell sorting to show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation.
Fri Jul 01 00:00:00 EDT 2011
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Journal of cell science
Meziane el K,Randle SJ,Nelson DE,Lomonosov M,Laman H
12-0251 was used in Flow cytometry/Cell sorting to test the ability of Fbxo7 to transform haematopoietic pro-B cells.
Fri Jul 01 00:00:00 EDT 2011
A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer.
Nature communications
Reppert S,Boross I,Koslowski M,Türeci Ö,Koch S,Lehr HA,Finotto S
12-0251 was used in Flow cytometry/Cell sorting to elucidate the role of the cytokine IL-17A in lung cancer and its potential for use in cancer therapy.
Tue Dec 20 00:00:00 EST 2011
Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.
BMC immunology
Gustafsson K,Calounova G,Hjelm F,Kriz V,Heyman B,Grönvik KO,Mostoslavsky G,Welsh M
12-0251 was used in Flow cytometry/Cell sorting to suggest that Shb is an important modulator of TCR signalling, that can regulate the murine peripheral CD4+ Th2 cell response.
Tue Jan 11 00:00:00 EST 2011
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.
The Journal of biological chemistry
Brockmeyer C,Paster W,Pepper D,Tan CP,Trudgian DC,McGowan S,Fu G,Gascoigne NR,Acuto O,Salek M
12-0251 was used in an ELISA assay to investigate the kinetics of signal propagation after TCR-induced protein tyrosine phosphorylation.
Fri Mar 04 00:00:00 EST 2011
Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model.
Toxicological sciences : an official journal of the Society of Toxicology
Schulz VJ,Smit JJ,Willemsen KJ,Fiechter D,Hassing I,Bleumink R,Boon L,van den Berg M,van Duursen MB,Pieters RH
12-0251 was used in Flow cytometry/Cell sorting to study whether activation of aryl hydrocarbon receptors can suppress development of food allergic responses.
Sat Oct 01 00:00:00 EDT 2011
In vivo SPECT reporter gene imaging of regulatory T cells.
PloS one
Sharif-Paghaleh E,Sunassee K,Tavaré R,Ratnasothy K,Koers A,Ali N,Alhabbab R,Blower PJ,Lechler RI,Smyth LA,Mullen GE,Lombardi G
12-0251 was used in Flow cytometry/Cell sorting to validate a new technique to study the migratory patterns of T reg cells in vivo.
Fri Apr 06 00:00:00 EDT 2012
CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes.
Nature immunology
Barral P,Polzella P,Bruckbauer A,van Rooijen N,Besra GS,Cerundolo V,Batista FD
12-0251 was used in Flow cytometry/Cell sorting to investigate how and where invariant natural killer T cells encounter antigens in vivo.
Thu Apr 01 00:00:00 EDT 2010
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
The Journal of experimental medicine
Thompson ED,Enriquez HL,Fu YX,Engelhard VH
12-0251 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.
Mon Aug 02 00:00:00 EDT 2010
Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T-cell recruitment in a mouse model of psoriasis.
The Journal of investigative dermatology
Wang H,von Rohrscheidt J,Roehrbein J,Peters T,Sindrilaru A,Kess D,Preissner KT,Scharffetter-Kochanek K
12-0251 was used in Flow cytometry/Cell sorting to indicate that interaction between LFA-1 and ICAM-1 is causally involved in the pathogenesis of psoriasiform skin inflammation.
Mon Mar 01 00:00:00 EST 2010
8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.
Journal of immunology (Baltimore, Md. : 1950)
Singh TP,Schön MP,Wallbrecht K,Michaelis K,Rinner B,Mayer G,Schmidbauer U,Strohmaier H,Wang XJ,Wolf P
12-0251 was used in Flow cytometry/Cell sorting to elucidate the mechanism of PUVA for treatment of psoriasis, showing that inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involves CTLA4 signalling.
Tue Jun 15 00:00:00 EDT 2010
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B
12-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.
Mon Feb 15 00:00:00 EST 2010
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Grausenburger R,Bilic I,Boucheron N,Zupkovitz G,El-Housseiny L,Tschismarov R,Zhang Y,Rembold M,Gaisberger M,Hartl A,Epstein MM,Matthias P,Seiser C,Ellmeier W
12-0251 was used in Flow cytometry/Cell sorting to provide genetic evidence that HDAC1 is an essential HDAC that controls the magnitude of an inflammatory response by modulating cytokine expression in effector T cells.
Wed Sep 15 00:00:00 EDT 2010
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production.
Blood
Fang C,Zhang X,Miwa T,Song WC
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of complement receptors in development of inflammatory T-helper 17 cells.
Thu Jul 30 00:00:00 EDT 2009
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN
Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD
12-0251 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.
Sat Aug 01 00:00:00 EDT 2009
Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Zhou Q,Yan J,Putheti P,Wu Y,Sun X,Toxavidis V,Tigges J,Kassam N,Enjyoji K,Robson SC,Strom TB,Gao W
12-0251 was used in Flow cytometry/Cell sorting to study how besides Tregs, CD39 is also expressed on pre-existing memory T cells of Th1-, Th2- and Th17-types with heightened alloreactivity.
Thu Oct 01 00:00:00 EDT 2009
Lack of TNFR2 expression by CD4(+) T cells exacerbates experimental colitis.
European journal of immunology
Dayer Schneider J,Seibold I,Saxer-Sekulic N,Paredes BE,Saurer L,Mueller C
12-0251 was used in Flow cytometry/Cell sorting to assess the role of TNF receptor 2 signalling in the CD4(+) T-cell transfer model of colitis.
Wed Jul 01 00:00:00 EDT 2009
Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.
Journal of leukocyte biology
Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D
12-0251 was used in Flow cytometry/Cell sorting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..
Tue Sep 01 00:00:00 EDT 2009
CD1d-based combination therapy eradicates established tumors in mice.
Journal of immunology (Baltimore, Md. : 1950)
Teng MW,Sharkey J,McLaughlin NM,Exley MA,Smyth MJ
12-0251 was used in Flow cytometry/Cell sorting to test an approach to directly activate/mature antigen presenting cells using anti-CD1d mAbs for the treatment of cancer.
Sat Aug 01 00:00:00 EDT 2009
Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival.
Journal of immunology (Baltimore, Md. : 1950)
Chen Q,Davidson TS,Huter EN,Shevach EM
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of TLRs in adaptive immunity and in regulatory T cells.
Thu Oct 01 00:00:00 EDT 2009
Enhanced susceptibility to Leishmania infection in resistant mice in the absence of immediate early response gene X-1.
Journal of immunology (Baltimore, Md. : 1950)
Akilov OE,Ustyugova IV,Zhi L,Hasan T,Wu MX
12-0251 was used in Flow cytometry/Cell sorting to explore a potential role for immediate early response gene X-1 in control of the susceptibility to Leishmania major infection.
Tue Dec 15 00:00:00 EST 2009
GITR Blockade Facilitates Treg Mediated Allograft Survival.
Transplantation
Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF
12-0251 was used in Flow cytometry/Cell sorting to study how inflammation and other innate immune signals may activate antigen presenting cells to up-regulate GITR.
Fri Nov 27 00:00:00 EST 2009
Nylon wool purification alters the activation of T cells.
Molecular immunology
Wohler JE,Barnum SR
12-0251 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.
Sun Feb 01 00:00:00 EST 2009
Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling.
Infection and immunity
Mahon RN,Rojas RE,Fulton SA,Franko JL,Harding CV,Boom WH
12-0251 was used in Flow cytometry/Cell sorting to investigate whether M. tuberculosis could directly inhibit CD4(+) T-cell activation.
Thu Oct 01 00:00:00 EDT 2009
Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis.
PloS one
Poffenberger MC,Straka N,El Warry N,Fang D,Shanina I,Horwitz MS
12-0251 was used in Flow cytometry/Cell sorting to investigate the mechanism by which coxsackievirus infection leads to chronic autoimmune pathology, showing that lack of IL-6 heightens the early immune response.
Thu Jul 09 00:00:00 EDT 2009
Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells.
International journal of clinical and experimental medicine
Fan H,Wang J,Zhou X,Liu Z,Zheng SG
12-0251 was used in Flow cytometry/Cell sorting to investigate the use of TGF-beta-induced Treg cells to protect MHC-mismatched organ grafts from rejection in a clinical setting.
Tue Aug 25 00:00:00 EDT 2009
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.
Cell research
Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N
12-0251 was used in Flow cytometry/Cell sorting to investigate the role that IFNγ plays in mesenchymal stem cell mediated suppression of T cell proliferation.
Fri Aug 01 00:00:00 EDT 2008
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.
Immunity
Tang Q,Adams JY,Penaranda C,Melli K,Piaggio E,Sgouroudis E,Piccirillo CA,Salomon BL,Bluestone JA
12-0251 was used in Flow cytometry/Cell sorting to suggest intra-islet Treg cell dysfunction secondary to defective IL-2 production as a cause of breakdown of self-tolerance and development of diabetes.
Thu May 01 00:00:00 EDT 2008
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-0251 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.
The Journal of clinical investigation
Wang H,Peters T,Sindrilaru A,Kess D,Oreshkova T,Yu XZ,Seier AM,Schreiber H,Wlaschek M,Blakytny R,Röhrbein J,Schulz G,Weiss JM,Scharffetter-Kochanek K
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in the pathogenesis of psoriasis, showing that the TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18.
Tue Jul 01 00:00:00 EDT 2008
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-0251 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.
Hepatology (Baltimore, Md.)
You Q,Cheng L,Kedl RM,Ju C
12-0251 was used in Flow cytometry/Cell sorting to examine the ability of Kupffer cells to present antigens and to suppress T cell activation by splenic dendritic cells.
Mon Sep 01 00:00:00 EDT 2008
CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype.
International immunology
Guo Z,Jang MH,Otani K,Bai Z,Umemoto E,Matsumoto M,Nishiyama M,Yamasaki M,Ueha S,Matsushima K,Hirata T,Miyasaka M
12-0251 was used in Flow cytometry/Cell sorting to investigate the functions of CD4(+)CD25(+) Tregs in the gut, showing that Tregs in the small intestinal lamina propria show an effector/memory phenotype.
Sat Mar 01 00:00:00 EST 2008
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
12-0251 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 EDT 2007
Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses.
The Journal of experimental medicine
Reiley WW,Jin W,Lee AJ,Wright A,Wu X,Tewalt EF,Leonard TO,Norbury CC,Fitzpatrick L,Zhang M,Sun SC
12-0251 was used in Flow cytometry/Cell sorting to show that the deubiquitinating enzyme, CYLD, plays a pivotal role in regulating T cell activation and homeostasis.
Mon Jun 11 00:00:00 EDT 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 EDT 2007
Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses.
Cancer research
Tuve S,Chen BM,Liu Y,Cheng TL,Touré P,Sow PS,Feng Q,Kiviat N,Strauss R,Ni S,Li ZY,Roffler SR,Lieber A
Fri Jun 15 00:00:00 EDT 2007
TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets.
Journal of leukocyte biology
Pyzik M,Piccirillo CA
12-0251 was used in Flow cytometry/Cell sorting to investigate the effects of TGF-beta on the induction or maintenance of regulatory functions in different T cell subsets.
Wed Aug 01 00:00:00 EDT 2007
Novel exosome-targeted CD4+ T cell vaccine counteracting CD4+25+ regulatory T cell-mediated immune suppression and stimulating efficient central memory CD8+ CTL responses.
Journal of immunology (Baltimore, Md. : 1950)
Hao S,Liu Y,Yuan J,Zhang X,He T,Wu X,Wei Y,Sun D,Xiang J
12-0251 was used in Flow cytometry/Cell sorting to study the effects of a novel exosome-targeted CD4+ T cell vaccine.
Sat Sep 01 00:00:00 EDT 2007
Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Silver PB,Agarwal RK,Su SB,Suffia I,Grajewski RS,Luger D,Chan CC,Mahdi RM,Nickerson JM,Caspi RR
12-0251 was used in Flow cytometry/Cell sorting to show that expression of a privileged retinal Ag in the periphery through hydrodynamic DNA vaccination affords protection from experimental autoimmune uveitis.
Mon Oct 15 00:00:00 EDT 2007
A key role of dendritic cells in probiotic functionality.
PloS one
Foligne B,Zoumpopoulou G,Dewulf J,Ben Younes A,Chareyre F,Sirard JC,Pot B,Grangette C
12-0251 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in the anti-inflammatory potential of probiotic lactic acid bacteria.
Wed Mar 21 00:00:00 EDT 2007
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Immunity
Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B
12-0251 was used in Flow cytometry/Cell sorting to investigate the generation of IL-17-producing T cells from naive CD4 T cells, showing that TGFbeta supports de novo differentiation of IL-17-producing T cells.
Wed Feb 01 00:00:00 EST 2006
Thymic output in aged mice.
Proceedings of the National Academy of Sciences of the United States of America
Hale JS,Boursalian TE,Turk GL,Fink PJ
12-0251 was used in Flow cytometry/Cell sorting to analyse the function and population dynamics of newly emigrated T-cells in aged mice.
Tue May 30 00:00:00 EDT 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
12-0251 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
12-0251 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
Distinct roles of IL-7 and stem cell factor in the OP9-DL1 T-cell differentiation culture system.
Experimental hematology
Wang H,Pierce LJ,Spangrude GJ
12-0251 was used in Flow cytometry/Cell sorting to demonstrate specific roles of SCF, IL-7, and Flt3L in promoting efficient T-lineage differentiation.
Fri Dec 01 00:00:00 EST 2006
Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.
Molecular and cellular biology
Yu CT,Feng MH,Shih HM,Lai MZ
12-0251 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.
Mon Jul 01 00:00:00 EDT 2002
Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.
Molecular and cellular biology
Yu CT,Feng MH,Shih HM,Lai MZ
12-0251 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.
Mon Jul 01 00:00:00 EDT 2002
Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.
Molecular and cellular biology
Yu CT,Feng MH,Shih HM,Lai MZ
12-0251 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.
Mon Jul 01 00:00:00 EDT 2002
