Product References
6-Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD-1 to inhibit PD-1 signalling and enhance T cell function.
Immunology
Liu L,Lei Y,Zheng Z,Zhou X,Chen S,Zeng G,Yu L,Wang P,Chen L
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2023
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.
Molecular pain
Lenert ME,Szabo-Pardi TA,Burton MD
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2023
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Nature communications
Choi BJ,Park MH,Park KH,Han WH,Yoon HJ,Jung HY,Hong JY,Chowdhury MR,Kim KY,Lee J,Song IS,Pang M,Choi MK,Gulbins E,Reichel M,Kornhuber J,Hong CW,Kim C,Kim SH,Schuchman EH,Jin HK,Bae JS
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy.
Theranostics
Jiang Q,Qiao B,Lin X,Cao J,Zhang N,Guo H,Liu W,Zhu L,Xie X,Wan L,Tang R,Liang B,Wang D,Wang Z,Zhou Y,Ran H,Li P
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Mar 07 00:00:00 EST 2022
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.
Theranostics
Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Aug 16 00:00:00 EDT 2022
Organoids capture tissue-specific innate lymphoid cell development in mice and humans.
Cell reports
Jowett GM,Read E,Roberts LB,Coman D,Vilà González M,Zabinski T,Niazi U,Reis R,Trieu TJ,Danovi D,Gentleman E,Vallier L,Curtis MA,Lord GM,Neves JF
14-0251-86 was used in Co-culture Assay to demonstrate that human epithelial cells recapitulate maturation of ILC from a stringent systemic human ILCP population, but only when the organoid-associated stromal cells are depleted.
Tue Aug 30 00:00:00 EDT 2022
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation.
Frontiers in cell and developmental biology
Li Z,Zhang W,Luo F,Li J,Yang W,Zhu B,Wu Q,Wang X,Sun C,Xie Y,Xu B,Wang Z,Qian F,Chen J,Wan Y,Hu W
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Neutralization
Sat Jun 26 00:00:00 EDT 2021
TRPM8 channel augments T-cell activation and proliferation.
Cell biology international
Acharya TK,Tiwari A,Majhi RK,Goswami C
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.
Molecular medicine reports
Huo J,Liu T,Li F,Song X,Hou X
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Mar 17 00:00:00 EDT 2021
Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.
Frontiers in immunology
Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.
International journal of molecular sciences
Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Immunohistochemistry
Sat Apr 03 00:00:00 EDT 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Aug 30 00:00:00 EDT 2021
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.
Journal of neuroinflammation
Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sat Jan 30 00:00:00 EST 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis.
BMC endocrine disorders
Wei Y,Jing J,Peng Z,Liu X,Wang X
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Jan 28 00:00:00 EST 2022
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
Cell
Ho JSY,Angel M,Ma Y,Sloan E,Wang G,Martinez-Romero C,Alenquer M,Roudko V,Chung L,Zheng S,Chang M,Fstkchyan Y,Clohisey S,Dinan AM,Gibbs J,Gifford R,Shen R,Gu Q,Irigoyen N,Campisi L,Huang C,Zhao N,Jones JD,van Knippenberg I,Zhu Z,Moshkina N,Meyer L,Noel J,Peralta Z,Rezelj V,Kaake R,Rosenberg B,Wang B,Wei J,Paessler S,Wise HM,Johnson J,Vannini A,Amorim MJ,Baillie JK,Miraldi ER,Benner C,Brierley I,Digard P,Łuksza M,Firth AE,Krogan N,Greenbaum BD,MacLeod MK,van Bakel H,Garcìa-Sastre A,Yewdell JW,Hutchinson E,Marazzi I
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Oct 07 00:00:00 EDT 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Oct 05 00:00:00 EDT 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-0251-86 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 EDT 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Jul 30 00:00:00 EDT 2020
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Cell reports
Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Western Blot
Tue Mar 03 00:00:00 EST 2020
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.
Cell reports
Flosbach M,Oberle SG,Scherer S,Zecha J,von Hoesslin M,Wiede F,Chennupati V,Cullen JG,List M,Pauling JK,Baumbach J,Kuster B,Tiganis T,Zehn D
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Jul 28 00:00:00 EDT 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Science advances
Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H
14-0251-86 was used in Flow Cytometry to demonstrate the endogenous existence of a micropeptide encoded by a transcript annotated as "non-protein coding" and characterize a micropeptide as a regulator of antigen presentation and a suppressor of inflammatory diseases.
Fri May 01 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-0251-86 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Jun 11 00:00:00 EDT 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Jan 30 00:00:00 EST 2019
SCGN deficiency results in colitis susceptibility.
eLife
Sifuentes-Dominguez LF,Li H,Llano E,Liu Z,Singla A,Patel AS,Kathania M,Khoury A,Norris N,Rios JJ,Starokadomskyy P,Park JY,Gopal P,Liu Q,Tan S,Chan L,Ross T,Harrison S,Venuprasad K,Baker LA,Jia D,Burstein E
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Oct 30 00:00:00 EDT 2019
Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.
Scientific reports
Uehara M,Li X,Sheikhi A,Zandi N,Walker B,Saleh B,Banouni N,Jiang L,Ordikhani F,Dai L,Yonar M,Vohra I,Kasinath V,Orgill DP,Khademhosseini A,Annabi N,Abdi R
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Apr 25 00:00:00 EDT 2019
Modulating Shrimp Tropomyosin-Mediated Allergy: Hypoallergen DNA Vaccines Induce Regulatory T Cells to Reduce Hypersensitivity in Mouse Model.
International journal of molecular sciences
Wai CYY,Leung NYH,Leung PSC,Chu KH
14-0251-86 was used in In vivo experiments to demonstrate the potency of hypoallergen-encoding DNA vaccines as a therapeutic strategy for human shellfish allergy via the vigorous induction of functional Treg cells.
Thu Sep 19 00:00:00 EDT 2019
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
14-0251 was used in Flow cytometry/Cell sorting to reveal the innate-like pathogenic function of antigen non-related memory CD4+ T cells, which contribute to the development of autoimmune diseases.
Tue Feb 12 00:00:00 EST 2019
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
PloS one
Mathä L,Shim H,Steer CA,Yin YH,Martinez-Gonzalez I,Takei F
14-0251-86 was used in Flow Cytometry to suggest that female ILC2s are more readily activated than male ILC2s due to their gene expression at the naïve state, which is potentially influenced by the lung environment.
Mon Dec 16 00:00:00 EST 2019
Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.
Immunity
Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-0251 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-0251 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.
The Journal of allergy and clinical immunology
Bloodworth MH,Rusznak M,Pfister CC,Zhang J,Bastarache L,Calvillo SA,Chappell JD,Boyd KL,Toki S,Newcomb DC,Stier MT,Zhou W,Goleniewska K,Moore ML,Hartert TV,Niswender KD,Peebles RS
14-0251 was used in Flow cytometry/Cell sorting to investigate the effect of activating the GLP-1R signalling pathway on mice mimicking severe respiratory infection.
Wed Aug 01 00:00:00 EDT 2018
A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Duperret EK,Liu S,Paik M,Trautz A,Stoltz R,Liu X,Ze K,Perales-Puchalt A,Reed C,Yan J,Xu X,Weiner DB
14-0251 was used in Flow cytometry/Cell sorting to investigate if MAGE-A immunogens have the capacity to target multiple MAGE-A family members to prevent tumor immune escape.
Sat Dec 01 00:00:00 EST 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Mar 22 00:00:00 EDT 2019
Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy.
Cancer research
Taylor A,Rothstein D,Rudd CE
14-0251 was used in Flow cytometry/Cell sorting to show how GSK-3 inhibitors that downregulate PD-1 expression can enhance CD8+ T-cell function in cancer therapy to a similar degree as PD-1 blocking antibodies, offering a next-generation approach in the design of immunotherapeutic approaches for cancer management.
Thu Feb 01 00:00:00 EST 2018
Divergent Roles of Interferon-γ and Innate Lymphoid Cells in Innate and Adaptive Immune Cell-Mediated Intestinal Inflammation.
Frontiers in immunology
Brasseit J,Kwong Chung CKC,Noti M,Zysset D,Hoheisel-Dickgreber N,Genitsch V,Corazza N,Mueller C
14-0251 was used in Flow cytometry/Cell sorting to investigate the role of aberrant interferon gamma in experimental mouse models of innate and adaptive immune cell-mediated intestinal inflammation using genetically and microbiota-stabilised hosts.
Thu Feb 14 00:00:00 EST 2019
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ferdinand JR,Richard AC,Meylan F,Al-Shamkhani A,Siegel RM
14-0251 was used in Flow cytometry/Cell sorting to suggest differential roles for membrane and soluble TL1A on adaptive and innate immune cells and have implications for the consequences of blocking these two forms of TL1A.
Thu Feb 15 00:00:00 EST 2018
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.
Experimental and therapeutic medicine
Wei Y,Zhang Z,Wang F,Zhou S
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Jun 15 00:00:00 EDT 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-0251 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
The Journal of experimental medicine
Singh PB,Pua HH,Happ HC,Schneider C,von Moltke J,Locksley RM,Baumjohann D,Ansel KM
14-0251 was used in Flow cytometry/Cell sorting to establish the physiological requirements for miRNAs in ILC2 homeostasis and immune function ans compare the global miRNA repertoire of resting and activated ILC2s and T helper type 2 cells.
Mon Dec 04 00:00:00 EST 2017
TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB.
EMBO molecular medicine
Huang SC,Wei PC,Hwang-Verslues WW,Kuo WH,Jeng YM,Hu CM,Shew JY,Huang CS,Chang KJ,Lee EY,Lee WH
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Neutralization
Fri Dec 01 00:00:00 EST 2017
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
14025186 was used in flow cytometry to characterize conventional and regulatory T cells during pregnancy
Tue Jan 10 00:00:00 EST 2017
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.
Journal of virology
Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK
14-0251 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.
Mon May 15 00:00:00 EDT 2017
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
Journal of immunology (Baltimore, Md. : 1950)
Leech JM,Lacey KA,Mulcahy ME,Medina E,McLoughlin RM
14025186 was used in flow cytometry to define the functions of IL-10 during Staphylococcus aureus
Wed Mar 15 00:00:00 EDT 2017
miR-451 limits CD4+ T cell proliferative responses to infection in mice.
Immunologic research
Chapman LM,Ture SK,Field DJ,Morrell CN
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.
Tue Aug 01 00:00:00 EDT 2017
Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities.
Oncology reports
Masuda J,Takayama E,Strober W,Satoh A,Morimoto Y,Honjo Y,Ichinohe T,Tokuno SI,Ishizuka T,Nakata T,Mizutani A,Umemura N,Kitani A,Fuss IJ,Shigehiro T,Kawaki H,Mizuno-Kamiya M,Kondoh N,Seno M
14-0251 was used in Flow cytometry/Cell sorting to suggest that the mode of tumor development has differential effects on systemic immunity that may, in turn, influence approaches to treatment of cancer patients.
Sat Jul 01 00:00:00 EDT 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon May 15 00:00:00 EDT 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
14025186 was used in flow cytometry to assess if aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts
Fri Jan 06 00:00:00 EST 2017
Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster.
Scientific reports
Kim M,Kim TJ,Kim HM,Doh J,Lee KM
Wed Jan 11 00:00:00 EST 2017
A robust in vitro model for trans-lymphatic endothelial migration.
Scientific reports
Xiong Y,Brinkman CC,Famulski KS,Mongodin EF,Lord CJ,Hippen KL,Blazar BR,Bromberg JS
14-0251 was used in Flow cytometry/Cell sorting to establish an in vitro system to evaluate lymphatic Trans-endothelial migration for various cell types across primary mouse and human lymphatic endothelial cells.
Tue May 09 00:00:00 EDT 2017
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Nature communications
Mbofung RM,McKenzie JA,Malu S,Zhang M,Peng W,Liu C,Kuiatse I,Tieu T,Williams L,Devi S,Ashkin E,Xu C,Huang L,Zhang M,Talukder AH,Tripathi SC,Khong H,Satani N,Muller FL,Roszik J,Heffernan T,Allison JP,Lizee G,Hanash SM,Proia D,Amaria R,Davis RE,Hwu P
14-0251 was used in Flow cytometry to show HSP90 inhibitors can potentiate T-cell-mediated anti-tumor immune responses to enhance T-cell-mediated killing of melanoma cells.
Wed Sep 06 00:00:00 EDT 2017
CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model.
Oncoimmunology
Gebauer C,Pignolet B,Yshii L,Mauré E,Bauer J,Liblau R
14-0251 was used in Flow cytometry/Cell sorting to provide further insight into the cellular mechanisms whereby a potent anti-tumor immunity triggers a cancer-associated autoimmune disease, and may therefore help to develop new therapeutic strategies against PND.
Tue Jan 12 00:00:00 EST 2021
Characterization of c-Maf+Foxp3- Regulatory T Cells Induced by Repeated Stimulation of Antigen-Presenting B Cells.
Scientific reports
Chien CH,Yu HC,Chen SY,Chiang BL
14025186 was used in flow cytometry to generate and characterize Treg-of-B cells
Wed Apr 12 00:00:00 EDT 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
14025186 was used in flow cytometry to assess the role of p38 signaling in limiting regulatory T cell induction
Fri Feb 03 00:00:00 EST 2017
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-0251 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 EDT 2016
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Nature immunology
Mujal AM,Gilden JK,Gérard A,Kinoshita M,Krummel MF
14-0251 was used in Flow cytometry/Cell sorting to characterise T cells lacking the septin cytoskeleton.
Tue Mar 01 00:00:00 EST 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
14-0251 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 EDT 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.
Circulation research
Li J,McArdle S,Gholami A,Kimura T,Wolf D,Gerhardt T,Miller J,Weber C,Ley K
14-0251-86 was used in Flow Cytometry to investigate the role of CCR5 in regulating T-cell homing to the atherosclerotic aorta and the functionality of the CCR5+ T effector cells.
Fri May 13 00:00:00 EDT 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-0251 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 EDT 2016
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS
14-0251 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.
Tue Nov 01 00:00:00 EDT 2016
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Autophagy
Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Aug 02 00:00:00 EDT 2016
Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells.
Cancer immunology, immunotherapy : CII
Foy SP,Mandl SJ,dela Cruz T,Cote JJ,Gordon EJ,Trent E,Delcayre A,Breitmeyer J,Franzusoff A,Rountree RB
14-0251 was used in Flow cytometry/Cell sorting to help elucidate evidence of enhanced clinical benefit from combining CTLA-4 blockade with poxvirus-based active immunotherapy.
Sun May 01 00:00:00 EDT 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population.
Journal of immunology (Baltimore, Md. : 1950)
Ju X,Silveira PA,Hsu WH,Elgundi Z,Alingcastre R,Verma ND,Fromm PD,Hsu JL,Bryant C,Li Z,Kupresanin F,Lo TH,Clarke C,Lee K,McGuire H,Fazekas de St Groth B,Larsen SR,Gibson J,Bradstock KF,Clark GJ,Hart DN
14025186 was used in flow cytometry to determine which cells express CD83
Thu Dec 15 00:00:00 EST 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0251 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen LC,Nicholson YT,Rosborough BR,Thomson AW,Raimondi G
14-0251 was used in Flow cytometry/Cell sorting to provide a framework for how the migratory behaviour of Treg and Tconv might be differentially regulated for therapeutic purposes.
Mon Aug 15 00:00:00 EDT 2016
CryJ-LAMP DNA Vaccines for Japanese Red Cedar Allergy Induce Robust Th1-Type Immune Responses in Murine Model.
Journal of immunology research
Su Y,Connolly M,Marketon A,Heiland T
14-0251 was used in Flow cytometry/Cell sorting to suggest the CryJ-LAMP Vaccine has a potential as an effective therapeutic for JRC induced allergy by skewing Th1/Th2 responses.
Wed Mar 15 00:00:00 EDT 2017
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Molecular medicine reports
Gu L,Deng WS,Sun XF,Zhou H,Xu Q
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.
Journal of neuroimmunology
Keil M,Sonner JK,Lanz TV,Oezen I,Bunse T,Bittner S,Meyer HV,Meuth SG,Wick W,Platten M
14025186 was used in flow cytometry to investigate the role of general control non-derepressible 2 in resolving autoimmune neuroinflammation
Mon Aug 15 00:00:00 EDT 2016
Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model.
Experimental and therapeutic medicine
Ruan G,Tao B,Wang D,Li Y,Wu J,Yin G
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sun May 15 00:00:00 EDT 2016
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nature communications
Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Jun 21 00:00:00 EDT 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model.
Inflammation and regeneration
Tamura R,Uemoto S,Tabata Y
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Mar 31 00:00:00 EDT 2022
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
Nature communications
O'Leary CE,Riling CR,Spruce LA,Ding H,Kumar S,Deng G,Liu Y,Seeholzer SH,Oliver PM
14025186 was used in flow cytometry to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways
Mon Apr 18 00:00:00 EDT 2016
Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow's milk casein-induced allergic responses in mice.
Scientific reports
Kim AR,Kim HS,Kim DK,Nam ST,Kim HW,Park YH,Lee D,Lee MB,Lee JH,Kim B,Beaven MA,Kim HS,Kim YM,Choi WS
14-0251 was used in Flow cytometry/Cell sorting to discover that mesenteric IL-10-producing regulatory B cells control food allergy via Foxp3(+) regulatory T cells.
Wed Jan 20 00:00:00 EST 2016
Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow's milk casein-induced allergic responses in mice.
Scientific reports
Kim AR,Kim HS,Kim DK,Nam ST,Kim HW,Park YH,Lee D,Lee MB,Lee JH,Kim B,Beaven MA,Kim HS,Kim YM,Choi WS
14-0251 was used in Flow cytometry/Cell sorting to discover that mesenteric IL-10-producing regulatory B cells control food allergy via Foxp3(+) regulatory T cells.
Wed Jan 20 00:00:00 EST 2016
Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling.
Scientific reports
Pane JA,Fleming FE,Graham KL,Thomas HE,Kay TW,Coulson BS
14-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms of diabetes acceleration by rotaviruses.
Wed Jul 13 00:00:00 EDT 2016
Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.
Oncoimmunology
Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB
14-0251 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.
Tue Jan 12 00:00:00 EST 2021
GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal.
Cell death & disease
Le Q,Yao W,Chen Y,Yan B,Liu C,Yuan M,Zhou Y,Ma L
14025186 was used in flow cytometry to use knockout mice to determine if GRK6 contributes to hematopoiesis
Thu Nov 24 00:00:00 EST 2016
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
14-0251 was used in Flow cytometry/Cell sorting to investigate whether the CpG-binding protein Cxxc1 plays a role in thymocyte development.
Mon May 23 00:00:00 EDT 2016
The MEK inhibitor trametinib separates murine graft-versus-host disease from graft-versus-tumor effects.
JCI insight
Itamura H,Shindo T,Tawara I,Kubota Y,Kariya R,Okada S,Komanduri KV,Kimura S
14-0251 was used in Flow cytometry/Cell sorting to confirm that trametinib selectively suppresses graft-versus-host disease inducing T cells while sparing antitumor T cells in vivo.
Thu Jul 07 00:00:00 EDT 2016
IL-7 signalling represses Bcl-6 and the TFH gene program.
Nature communications
McDonald PW,Read KA,Baker CE,Anderson AE,Powell MD,Ballesteros-Tato A,Oestreich KJ
14-0251 was used in Flow cytometry/Cell sorting to study the effect of differential cytokine signalling on TFH and TCM development from TH1 cells.
Fri Jan 08 00:00:00 EST 2016
Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells.
Scientific reports
do Canto FB,Campos SM,Granato A,da Silva RF,de Paiva LS,Nóbrega A,Bellio M,Fucs R
14-0251 was used in Flow cytometry/Cell sorting to show that augmentation of naïve T cell numbers in the inoculum of RAG KO mice suppresses colon disease and promotes immune homeostasis.
Wed Jun 29 00:00:00 EDT 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
14-0251-86 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 EDT 2016
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-0251 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.
PLoS pathogens
Mitagami Y,Yasunaga J,Kinosada H,Ohshima K,Matsuoka M
14-0251 was used in Flow cytometry/Cell sorting to investigate the effect of interferon-γ on inflammation and T-cell lymphoma development in HTLV-1 bZIP factor transgenic mice.
Sat Aug 01 00:00:00 EDT 2015
Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models.
Molecular cancer therapeutics
Cuadrado-Castano S,Ayllon J,Mansour M,de la Iglesia-Vicente J,Jordan S,Tripathi S,García-Sastre A,Villar E
14-0251 was used in Flow cytometry/Cell sorting to demonstrate an augmented agent for cancer therapy which exploits the oncolytic properties of Newcastle disease virus.
Fri May 01 00:00:00 EDT 2015
Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.
International journal of obesity (2005)
Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2015
Regulation of asymmetric division and CD8+ T lymphocyte fate specification by protein kinase Cζ and protein kinase Cλ/ι.
Journal of immunology (Baltimore, Md. : 1950)
Metz PJ,Arsenio J,Kakaradov B,Kim SH,Remedios KA,Oakley K,Akimoto K,Ohno S,Yeo GW,Chang JT
14-0251 was used in Immunocytochemistry-immunoflourescence to show that PKCζ and PKCλ/i regulate asymmetric localization of effector fate-associated factors during the first CD8+ T cell division in vivo.
Sun Mar 01 00:00:00 EST 2015
Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S
14-0251-86 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.
Sun Mar 15 00:00:00 EDT 2015
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Park HJ,Park JS,Jeong YH,Son J,Ban YH,Lee BH,Chen L,Chang J,Chung DH,Choi I,Ha SJ
14-0251 was used in Flow cytometry/Cell sorting to define PD-1 upregulated on Treg cells and its interaction with PD-1 ligand on effector T cells as one cause for the potent T cell suppression.
Mon Jun 15 00:00:00 EDT 2015
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.
Molecular and cellular biology
Fabbiano S,Menacho-Márquez M,Robles-Valero J,Pericacho M,Matesanz-Marín A,García-Macías C,Sevilla MA,Montero MJ,Alarcón B,López-Novoa JM,Martín P,Bustelo XR
14-0251 was used in Flow cytometry/Cell sorting to determine that TREG cells constitute a first protective barrier against hypertension-driven tissue fibrosis.
Thu Oct 01 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Full activation of CD4+ T cells early during sepsis requires specific antigen.
Shock (Augusta, Ga.)
Schmoeckel K,Traffehn S,Eger C,Pötschke C,Bröker BM
14-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms of T-cell activation and its consequences during sepsis, showing that full activation requires a specific antigen.
Sun Feb 01 00:00:00 EST 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation.
PloS one
Derkow K,Krüger C,Dembny P,Lehnardt S
14-0251 was used in Flow cytometry/Cell sorting to investigate the crosstalk between γδ T cells and microglia activated by Toll-like receptors in the context of neuronal damage.
Tue May 17 00:00:00 EDT 2016
Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.
Scientific reports
Singh K,Kadesjö E,Lindroos J,Hjort M,Lundberg M,Espes D,Carlsson PO,Sandler S,Thorvaldson L
14-0251 was used in Flow cytometry/Cell sorting to suggest that insufficient IL-35 levels play a pivotal role in the development of T1D and that treatment with IL-35 should be investigated in treatment of T1D and other autoimmune diseases.
Thu Jul 30 00:00:00 EDT 2015
T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens.
Cell reports
Voisinne G,Nixon BG,Melbinger A,Gasteiger G,Vergassola M,Altan-Bonnet G
14-0251 was used in Neutralization experiments to identify the PI3K pathway as being critical for integrating the antigen and cytokine responses necessary for controlling cell-cycle entry.
Tue May 26 00:00:00 EDT 2015
Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica.
PloS one
Zhou S,Jin X,Chen X,Zhu J,Xu Z,Wang X,Liu F,Hu W,Zhou L,Su C
14-0251 was used in Functional assays to identify SjHSP60 as a major parasitic contributor of Treg induction in S. japonicum egg antigens.
Tue Jun 14 00:00:00 EDT 2016
Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
PloS one
Tamehiro N,Oda H,Shirai M,Suzuki H
14-0251 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.
Mon Apr 25 00:00:00 EDT 2016
Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice.
Journal of neuroinflammation
Djukic M,Sostmann N,Bertsch T,Mecke M,Nessler S,Manig A,Hanisch UK,Triebel J,Bollheimer LC,Sieber C,Nau R
14-0251 was used in Flow cytometry/Cell sorting to suggest a detrimental role of vitamin D deficiency in bacterial central nervous system infections.
Wed Jan 07 00:00:00 EST 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.
Nature immunology
Xiao N,Eto D,Elly C,Peng G,Crotty S,Liu YC
14-0251 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms that regulate the induction of T(FH) cells, showing that Itch is required.
Tue Jul 01 00:00:00 EDT 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-0251 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America
Rashkovan M,Vadnais C,Ross J,Gigoux M,Suh WK,Gu W,Kosan C,Möröy T
14-0251 was used in Flow cytometry/Cell sorting to show how the protein Miz-1 restricts p53-dependent apoptosis in pro-B and pre-T cells actively rearranging antigen receptor genes.
Tue Dec 16 00:00:00 EST 2014
Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hongo D,Tang X,Baker J,Engleman EG,Strober S
14-0251 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms required for suitable immune tolerance for combined bone marrow and heart transplant acceptance in mice.
Sat Nov 01 00:00:00 EDT 2014
Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.
Diabetes
Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C
14-0251 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.
Sun Jun 01 00:00:00 EDT 2014
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
Journal of immunology (Baltimore, Md. : 1950)
Duong S,Condotta SA,Rai D,Martin MD,Griffith TS,Badovinac VP
14-0251 was used in Flow cytometry/Cell sorting to study the role of sepsis in shaping the quantity and functionality of infection- or vaccine-induced memory CD8 T cells.
Tue Apr 15 00:00:00 EDT 2014
Regulatory CD4+ T cells promote B cell anergy in murine lupus.
Journal of immunology (Baltimore, Md. : 1950)
Liu Y,Liu A,Iikuni N,Xu H,Shi FD,La Cava A
14-0251 was used in Flow cytometry/Cell sorting to identify a mechanism by which regulatory T-cells can control production of autoantibodies in lupus B-cells.
Thu May 01 00:00:00 EDT 2014
B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lamagna C,Hu Y,DeFranco AL,Lowell CA
14-0251-86 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.
Sat Feb 01 00:00:00 EST 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
Nature communications
Li Q,Zou J,Wang M,Ding X,Chepelev I,Zhou X,Zhao W,Wei G,Cui J,Zhao K,Wang HY,Wang RF
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-0251 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 EDT 2015
Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection.
Journal of neuroinflammation
Ribes S,Meister T,Ott M,Redlich S,Janova H,Hanisch UK,Nessler S,Nau R
14-0251 was used in Flow cytometry/Cell sorting to suggest that systemic administration of CpG ODN may help to prevent bacterial CNS infections in immunocompromised individuals.
Thu Jan 23 00:00:00 EST 2014
Hematopoietic progenitor cell lines with myeloid and lymphoid potential.
Nature methods
Redecke V,Wu R,Zhou J,Finkelstein D,Chaturvedi V,High AA,Häcker H
14-0251 was used in Flow cytometry/Cell sorting to develop methods to investigate immune-cell differentiation and function, showing that immortalised hematopoietic progenitor cell lines can be produced, with myeloid and lymphoid potential.
Thu Aug 01 00:00:00 EDT 2013
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.
Kidney international
Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X
14-0251 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.
Sun Sep 01 00:00:00 EDT 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Delicate balance among three types of T cells in concurrent regulation of tumor immunity.
Cancer research
Izhak L,Ambrosino E,Kato S,Parish ST,O'Konek JJ,Weber H,Xia Z,Venzon D,Berzofsky JA,Terabe M
14-0251 was used in Flow cytometry/Cell sorting to study the dominance of regulatory T cells and type II natural killer T cells in the colorectal and renal tumour environment.
Fri Mar 01 00:00:00 EST 2013
Aire deficiency promotes TRP-1-specific immune rejection of melanoma.
Cancer research
Zhu ML,Nagavalli A,Su MA
14-0251 was used in Flow cytometry/Cell sorting to show how Aire deficiency can enhance immune responses against melanoma and offer a logical strategy to enhance immune rejection of melanoma.
Mon Apr 01 00:00:00 EDT 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
TGF-β signalling is required for CD4⁺ T cell homeostasis but dispensable for regulatory T cell function.
PLoS biology
Sledzińska A,Hemmers S,Mair F,Gorka O,Ruland J,Fairbairn L,Nissler A,Müller W,Waisman A,Becher B,Buch T
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that TGF-β signalling is not necessary for peripheral tolerance on mature CD4&8314 T cells.
Tue Oct 01 00:00:00 EDT 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
14-0251 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance.
American journal of physiology. Endocrinology and metabolism
Guo CA,Kogan S,Amano SU,Wang M,Dagdeviren S,Friedline RH,Aouadi M,Kim JK,Czech MP
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD
14-0251 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.
Tue Jan 01 00:00:00 EST 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-0251 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 EDT 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes.
PloS one
Diaz-de-Durana Y,Lau J,Knee D,Filippi C,Londei M,McNamara P,Nasoff M,DiDonato M,Glynne R,Herman AE
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
14-0251 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
Combination of SLC administration and Tregs depletion is an attractive strategy for targeting hepatocellular carcinoma.
Molecular cancer
Chen L,Zhou S,Qin J,Hu H,Ma H,Liu B,Wang X,Ma J,Ye S,Zhong C,Zhou G,Liang C
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that intratumoral co-administration of secondary lymphoid tissue chemokine and anti-CD25 mAbs are an effective treatment for hepatocellular carcinoma.
Thu Dec 05 00:00:00 EST 2013
Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction.
PloS one
Duwaerts CC,Sun EP,Cheng CW,van Rooijen N,Gregory SH
14-0251 was used in Flow cytometry/Cell sorting to investigate whether iNKT and Kupffer cell suppression of neutrophil-dependent liver injury is interdependent, showing that cross-activation allows suppression of injury.
Fri Jul 11 00:00:00 EDT 2014
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
14-0251 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 EDT 2014
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0251 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Castillo EF,Dekonenko A,Arko-Mensah J,Mandell MA,Dupont N,Jiang S,Delgado-Vargas M,Timmins GS,Bhattacharya D,Yang H,Hutt J,Lyons CR,Dobos KM,Deretic V
14-0251 was used in Flow cytometry/Cell sorting to study the role of autophagy during immune responses to tuberculosis.
Tue Nov 13 00:00:00 EST 2012
Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.
Journal of controlled release : official journal of the Controlled Release Society
Jhunjhunwala S,Balmert SC,Raimondi G,Dons E,Nichols EE,Thomson AW,Little SR
14-0251 was used in Flow cytometry/Cell sorting to investigate alternative strategies to achieve an in situ increase in regulatory T cell abundance.
Tue Apr 10 00:00:00 EDT 2012
Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Koga T,Ichinose K,Mizui M,Crispín JC,Tsokos GC
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that calcium/calmodulin-dependent protein kinase IV plays a central role in development of autoimmunity in MRL/lpr mice.
Mon Oct 01 00:00:00 EDT 2012
Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis.
World journal of gastroenterology
van der Marel S,Majowicz A,Kwikkers K,van Logtenstein R,te Velde AA,De Groot AS,Meijer SL,van Deventer SJ,Petry H,Hommes DW,Ferreira V
14-0251 was used in Flow cytometry/Cell sorting to explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of regulatory T-cell epitopes in a mouse model of experimental colitis.
Tue Aug 28 00:00:00 EDT 2012
CD69 does not affect the extent of T cell priming.
PloS one
Alari-Pahissa E,Notario L,Lorente E,Vega-Ramos J,Justel A,López D,Villadangos JA,Lauzurica P
14-0251 was used in Flow cytometry/Cell sorting to investigate the role of CD69 in T cell activation, showing that CD69 does not affect the extent of T cell priming.
Mon May 06 00:00:00 EDT 2013
Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells.
PloS one
Schallenberg S,Petzold C,Tsai PY,Sparwasser T,Kretschmer K
14-0251 was used in Flow cytometry/Cell sorting to perform a comparative analysis of thymic Treg cell development and peripheral compartments of mature Treg cells in various transgenic Foxp3-fluorochrome reporter mouse strains.
Thu Jan 10 00:00:00 EST 2013
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.
Immunity
Hall JA,Cannons JL,Grainger JR,Dos Santos LM,Hand TW,Naik S,Wohlfert EA,Chou DB,Oldenhove G,Robinson M,Grigg ME,Kastenmayer R,Schwartzberg PL,Belkaid Y
14-0251 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid in responses to infection, showing that it is essential in the promotion of CD4(+) T cell effector responses.
Fri Mar 25 00:00:00 EDT 2011
NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.
Journal of hepatology
Cheng CW,Duwaerts CC,Rooijen Nv,Wintermeyer P,Mott S,Gregory SH
14-0251 was used in Flow cytometry/Cell sorting to investigate the response of NK cells to liver injury that occurs in a mouse model of biliary obstruction.
Fri Apr 01 00:00:00 EDT 2011
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
14-0251 was used in Functional assays to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 EDT 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-0251 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 EST 2011
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Published figure using CD25 monoclonal antibody (Product # 14-0251-86) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu.
Journal of immunology (Baltimore, Md. : 1950)
Divekar AA,Dubey S,Gangalum PR,Singh RR
14-0251 was used in Flow cytometry/Cell sorting to investigate mechanisms of potential Treg cell defects in systemic lupus erythematosus.
Sat Jan 15 00:00:00 EST 2011
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.
Journal of immunology (Baltimore, Md. : 1950)
Van Belle TL,Esplugues E,Liao J,Juntti T,Flavell RA,von Herrath MG
14-0251 was used in Flow cytometry/Cell sorting to elucidate the role of IL-17 in viral infections and type 1 diabetes.
Thu Sep 15 00:00:00 EDT 2011
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.
Journal of immunology (Baltimore, Md. : 1950)
Hoves S,Sutton VR,Haynes NM,Hawkins ED,Fernández Ruiz D,Baschuk N,Sedelies KA,Schnurr M,Stagg J,Andrews DM,Villadangos JA,Trapani JA
14-0251 was used in Flow cytometry/Cell sorting to reveal a critical and previously unsuspected role for granzymes A and B in dictating immunogenicity by influencing the mode of tumour cell death.
Mon Aug 01 00:00:00 EDT 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-0251 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 EDT 2011
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Chen YG,Scheuplein F,Driver JP,Hewes AA,Reifsnyder PC,Leiter EH,Serreze DV
14-0251 was used in Flow cytometry/Cell sorting to demonstrate the presence of a T1D resistance gene closely linked to the ablated Cd38 allele in the previously reported NOD stock also lacking ART2.
Fri Apr 01 00:00:00 EDT 2011
IL-2 limits IL-12 enhanced lymphocyte proliferation during Leishmania amazonensis infection.
Cellular immunology
Ramer-Tait AE,Petersen CA,Jones DE
14-0251 was used in Flow cytometry/Cell sorting to suggest that during chronic infection with Leishmania amazonensis, IL-2 plays a dominant immunosuppressive role.
Tue Oct 04 00:00:00 EDT 2011
Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.
PloS one
McFarland AP,Savan R,Wagage S,Addison A,Ramakrishnan K,Karwan M,Duong T,Young HA
14-0251 was used in Flow cytometry/Cell sorting to identify a correlation between the loss/down-regulation of IFNAR1 on DCs and exacerbation of colitis.
Fri Feb 18 00:00:00 EST 2011
N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis.
The Journal of biological chemistry
Grigorian A,Araujo L,Naidu NN,Place DJ,Choudhury B,Demetriou M
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that oral GlcNAc inhibits T-helper 1 and 17 responses, suppressing experimental autoimmune encephalomyelitis progression.
Fri Nov 18 00:00:00 EST 2011
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.
Science signaling
Ramadani F,Bolland DJ,Garcon F,Emery JL,Vanhaesebroeck B,Corcoran AE,Okkenhaug K
14-0251 was used in Flow cytometry/Cell sorting to study how either p110alpha or p110delta can mediate tonic signaling from the BCR, but only p110delta can contribute to antigen-dependent activation of B cells.
Tue Aug 10 00:00:00 EDT 2010
Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease.
Thorax
Thorburn AN,O'Sullivan BJ,Thomas R,Kumar RK,Foster PS,Gibson PG,Hansbro PM
14-0251 was used in in vivo experiments to demonstrate the potential of a Streptococcus pneumoniae vaccine as an immunoregulatory treatment for asthma.
Wed Dec 01 00:00:00 EST 2010
Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.
PLoS pathogens
Schmidt NW,Butler NS,Badovinac VP,Harty JT
14-0251 was used in Flow cytometry/Cell sorting to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses.
Thu Jul 15 00:00:00 EDT 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-0251 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-0251 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Armstrong AJ,Gebre AK,Parks JS,Hedrick CC
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that ATP-binding cassette transporter G1 regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells.
Fri Jan 01 00:00:00 EST 2010
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.
Immunity
Feuerer M,Shen Y,Littman DR,Benoist C,Mathis D
14-0251 was used in Flow cytometry/Cell sorting to explore when, where and how regulatory T cells exert their influence to control the progression of autoimmune disorders.
Fri Oct 16 00:00:00 EDT 2009
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-0251 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 EDT 2009
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Nature immunology
Marks BR,Nowyhed HN,Choi JY,Poholek AC,Odegard JM,Flavell RA,Craft J
14-0251 was used in Flow cytometry/Cell sorting to demonstrate that T(H)-17 cells, like Treg cells, can be selected by self antigens in the thymus.
Thu Oct 01 00:00:00 EDT 2009
Critical roles of lysosomal acid lipase in T cell development and function.
The American journal of pathology
Qu P,Du H,Wilkes DS,Yan C
14-0251-86 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.
Sun Mar 01 00:00:00 EST 2009
Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells.
International journal of biomedical science : IJBS
Tao X,Ma J,Zhang Y,Yu J,Cai L,Wang J,Zheng SG
14-0251 was used in Flow cytometry/Cell sorting to determine cytokine factors that can affect the ability of TGF-β to induce Foxp3 expression.
Sat Mar 01 00:00:00 EST 2008
Resistance of Foxp3+ regulatory T cells to Nur77-induced apoptosis promotes allograft survival.
PloS one
Tao R,Hancock WW
14-0251 was used in Functional assays to show that compared to conventional CD4 and CD8 T cells, Foxp3+ Tregs are relatively resistant to Nur77-mediated apoptosis.
Wed May 28 00:00:00 EDT 2008
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation
Humblet-Baron S,Sather B,Anover S,Becker-Herman S,Kasprowicz DJ,Khim S,Nguyen T,Hudkins-Loya K,Alpers CE,Ziegler SF,Ochs H,Torgerson T,Campbell DJ,Rawlings DJ
14-0251 was used in Flow cytometry/Cell sorting to investigate whether alterations in Treg function might explain Wiskott-Aldrich syndrome pathology, showing that WASp is required for Treg homeostasis.
Thu Feb 01 00:00:00 EST 2007
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
The Journal of experimental medicine
Sun CM,Hall JA,Blank RB,Bouladoux N,Oukka M,Mora JR,Belkaid Y
14-0251 was used in Flow cytometry/Cell sorting to investigate how the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
Mon Aug 06 00:00:00 EDT 2007
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.
The Journal of experimental medicine
Sather BD,Treuting P,Perdue N,Miazgowicz M,Fontenot JD,Rudensky AY,Campbell DJ
14-0251 was used in Flow cytometry/Cell sorting to investigate the factors which impact regulatory T cell homing receptor expression, tissue distribution and peripheral tolerance maintenance.
Mon Jun 11 00:00:00 EDT 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-0251 was used in Flow cytometry/Cell sorting to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 EST 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-0251 was used in Flow cytometry/Cell sorting to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 EST 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 EDT 2007
Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses.
Cancer research
Tuve S,Chen BM,Liu Y,Cheng TL,Touré P,Sow PS,Feng Q,Kiviat N,Strauss R,Ni S,Li ZY,Roffler SR,Lieber A
Fri Jun 15 00:00:00 EDT 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-0251 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 EST 2007
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.
Proceedings of the National Academy of Sciences of the United States of America
So T,Song J,Sugie K,Altman A,Croft M
14-0251 was used in Blocking experiments to show that OX40 provides a critical synergistic and temporal signal with other noncytokine receptors to modulate nuclear factor of activated T cells c1 and to promote optimal Th2 generation.
Tue Mar 07 00:00:00 EST 2006
The role of CD4 T cells in the pathogenesis of murine AIDS.
Journal of virology
Li W,Green WR
14-0251 was used in Flow cytometry/Cell sorting to investigate the possible regulatory role of natural regulatory T-cells in murine AIDS.
Thu Jun 01 00:00:00 EDT 2006
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
The Journal of experimental medicine
Knoechel B,Lohr J,Kahn E,Bluestone JA,Abbas AK
14-0251 was used in Flow cytometry/Cell sorting to show peripheral T cell reaction to a systemic antigen goes through a phase of effector cell-mediated pathology followed by T reg cell-mediated recovery, and both require IL-2.
Mon Nov 21 00:00:00 EST 2005
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.
Cancer research
Zou L,Barnett B,Safah H,Larussa VF,Evdemon-Hogan M,Mottram P,Wei S,David O,Curiel TJ,Zou W
14-0251 was used in Flow cytometry/Cell sorting to study the homeostatic and pathologic trafficking of Treg cells.
Mon Nov 15 00:00:00 EST 2004
