Product References
6-Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD-1 to inhibit PD-1 signalling and enhance T cell function.
Immunology
Liu L,Lei Y,Zheng Z,Zhou X,Chen S,Zeng G,Yu L,Wang P,Chen L
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2023
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.
Molecular pain
Lenert ME,Szabo-Pardi TA,Burton MD
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Inhibition Assays
Mon Feb 13 00:00:00 EST 2023
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.
Molecular pain
Lenert ME,Szabo-Pardi TA,Burton MD
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Inhibition Assays
Mon Feb 13 00:00:00 EST 2023
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Nature communications
Choi BJ,Park MH,Park KH,Han WH,Yoon HJ,Jung HY,Hong JY,Chowdhury MR,Kim KY,Lee J,Song IS,Pang M,Choi MK,Gulbins E,Reichel M,Kornhuber J,Hong CW,Kim C,Kim SH,Schuchman EH,Jin HK,Bae JS
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy.
Theranostics
Jiang Q,Qiao B,Lin X,Cao J,Zhang N,Guo H,Liu W,Zhu L,Xie X,Wan L,Tang R,Liang B,Wang D,Wang Z,Zhou Y,Ran H,Li P
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Mar 07 00:00:00 EST 2022
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.
Theranostics
Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Aug 16 00:00:00 EDT 2022
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation.
Frontiers in cell and developmental biology
Li Z,Zhang W,Luo F,Li J,Yang W,Zhu B,Wu Q,Wang X,Sun C,Xie Y,Xu B,Wang Z,Qian F,Chen J,Wan Y,Hu W
16-0251-85 was used in Functional assay to investigate the protective effects of Schistosoma japonicum on allergic airway inflammation.
Sat Jun 26 00:00:00 EDT 2021
Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation.
Frontiers in cell and developmental biology
Li Z,Zhang W,Luo F,Li J,Yang W,Zhu B,Wu Q,Wang X,Sun C,Xie Y,Xu B,Wang Z,Qian F,Chen J,Wan Y,Hu W
16-0251-85 was used in Functional assay to investigate the protective effects of Schistosoma japonicum on allergic airway inflammation.
Sat Jun 26 00:00:00 EDT 2021
TRPM8 channel augments T-cell activation and proliferation.
Cell biology international
Acharya TK,Tiwari A,Majhi RK,Goswami C
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.
Molecular medicine reports
Huo J,Liu T,Li F,Song X,Hou X
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Mar 17 00:00:00 EDT 2021
Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.
Frontiers in immunology
Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.
International journal of molecular sciences
Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Immunohistochemistry
Sat Apr 03 00:00:00 EDT 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Aug 30 00:00:00 EDT 2021
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.
Journal of neuroinflammation
Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat Jan 30 00:00:00 EST 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis.
BMC endocrine disorders
Wei Y,Jing J,Peng Z,Liu X,Wang X
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Jan 28 00:00:00 EST 2022
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
Cell
Ho JSY,Angel M,Ma Y,Sloan E,Wang G,Martinez-Romero C,Alenquer M,Roudko V,Chung L,Zheng S,Chang M,Fstkchyan Y,Clohisey S,Dinan AM,Gibbs J,Gifford R,Shen R,Gu Q,Irigoyen N,Campisi L,Huang C,Zhao N,Jones JD,van Knippenberg I,Zhu Z,Moshkina N,Meyer L,Noel J,Peralta Z,Rezelj V,Kaake R,Rosenberg B,Wang B,Wei J,Paessler S,Wise HM,Johnson J,Vannini A,Amorim MJ,Baillie JK,Miraldi ER,Benner C,Brierley I,Digard P,Łuksza M,Firth AE,Krogan N,Greenbaum BD,MacLeod MK,van Bakel H,Garcìa-Sastre A,Yewdell JW,Hutchinson E,Marazzi I
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Oct 07 00:00:00 EDT 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Oct 05 00:00:00 EDT 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Jul 30 00:00:00 EDT 2020
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Cell reports
Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Western Blot
Tue Mar 03 00:00:00 EST 2020
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.
Cell reports
Flosbach M,Oberle SG,Scherer S,Zecha J,von Hoesslin M,Wiede F,Chennupati V,Cullen JG,List M,Pauling JK,Baumbach J,Kuster B,Tiganis T,Zehn D
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jul 28 00:00:00 EDT 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells.
Cell reports
Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT
16-0251 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Tue Mar 10 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jun 11 00:00:00 EDT 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Distinct Requirements of CHD4 during B Cell Development and Antibody Response.
Cell reports
Yen WF,Sharma R,Cols M,Lau CM,Chaudhry A,Chowdhury P,Yewdell WT,Vaidyanathan B,Sun A,Coffre M,Pucella JN,Chen CC,Jasin M,Sun JC,Rudensky AY,Koralov SB,Chaudhuri J
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Apr 30 00:00:00 EDT 2019
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Jan 30 00:00:00 EST 2019
SCGN deficiency results in colitis susceptibility.
eLife
Sifuentes-Dominguez LF,Li H,Llano E,Liu Z,Singla A,Patel AS,Kathania M,Khoury A,Norris N,Rios JJ,Starokadomskyy P,Park JY,Gopal P,Liu Q,Tan S,Chan L,Ross T,Harrison S,Venuprasad K,Baker LA,Jia D,Burstein E
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Oct 30 00:00:00 EDT 2019
Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.
Scientific reports
Uehara M,Li X,Sheikhi A,Zandi N,Walker B,Saleh B,Banouni N,Jiang L,Ordikhani F,Dai L,Yonar M,Vohra I,Kasinath V,Orgill DP,Khademhosseini A,Annabi N,Abdi R
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Apr 25 00:00:00 EDT 2019
Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.
Immunity
Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
STAT5BN642H is a driver mutation for T cell neoplasia.
The Journal of clinical investigation
Pham HTT,Maurer B,Prchal-Murphy M,Grausenburger R,Grundschober E,Javaheri T,Nivarthi H,Boersma A,Kolbe T,Elabd M,Halbritter F,Pencik J,Kazemi Z,Grebien F,Hengstschläger M,Kenner L,Kubicek S,Farlik M,Bock C,Valent P,Müller M,Rülicke T,Sexl V,Moriggl R
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jan 02 00:00:00 EST 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Mar 22 00:00:00 EDT 2019
CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Frontiers in immunology
Cobbold SP,Adams E,Howie D,Waldmann H
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Jan 31 00:00:00 EST 2022
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
16-0251-85 was used in Functional assay to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
16-0251-85 was used in Functional assay to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Schloss J,Ali R,Racine JJ,Chapman HD,Serreze DV,DiLorenzo TP
16-0251 was used in Flow cytometry/Cell sorting to establish an NOD mouse model for the study of a class I MHC allele, HLA-B*39:06.
Tue May 15 00:00:00 EDT 2018
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.
Experimental and therapeutic medicine
Wei Y,Zhang Z,Wang F,Zhou S
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Jun 15 00:00:00 EDT 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB.
EMBO molecular medicine
Huang SC,Wei PC,Hwang-Verslues WW,Kuo WH,Jeng YM,Hu CM,Shew JY,Huang CS,Chang KJ,Lee EY,Lee WH
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Neutralization
Fri Dec 01 00:00:00 EST 2017
TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB.
EMBO molecular medicine
Huang SC,Wei PC,Hwang-Verslues WW,Kuo WH,Jeng YM,Hu CM,Shew JY,Huang CS,Chang KJ,Lee EY,Lee WH
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Neutralization
Fri Dec 01 00:00:00 EST 2017
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.
Journal of virology
Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK
16-0251 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.
Mon May 15 00:00:00 EDT 2017
Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation.
Gene therapy
Sun Y,Peng S,Yang A,Farmer E,Wu TC,Hung CF
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice.
Molecular medicine reports
Tang A,Li C,Chen Z,Li T
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon May 15 00:00:00 EDT 2017
Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.
JCI insight
Ikutani M,Tsuneyama K,Kawaguchi M,Fukuoka J,Kudo F,Nakae S,Arita M,Nagai Y,Takaki S,Takatsu K
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Apr 06 00:00:00 EDT 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Armc5 deletion causes developmental defects and compromises T-cell immune responses.
Nature communications
Hu Y,Lao L,Mao J,Jin W,Luo H,Charpentier T,Qi S,Peng J,Hu B,Marcinkiewicz MM,Lamarre A,Wu J
16-0251 was used in Flow cytometry/Cell sorting to study the developmental defects caused by ARMC5 deletion and how T-cell immune responses are compromised.
Tue Feb 07 00:00:00 EST 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
16-0251 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
16-0251 was used in Flow cytometry/Cell sorting to demonstrate the importance of TfR1 in adaptive immunity.
Fri Jan 01 00:00:00 EST 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.
The Journal of clinical investigation
Ohmura S,Mizuno S,Oishi H,Ku CJ,Hermann M,Hosoya T,Takahashi S,Engel JD
16-0251 was used in Flow cytometry/Cell sorting to show that Tce1 is necessary and sufficient for critical aspects of Gata3 T cell-specific transcriptional activity.
Tue Mar 01 00:00:00 EST 2016
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Autophagy
Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Aug 02 00:00:00 EDT 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Accumulation of Regulatory T Cells and Chronic Inflammation in the Middle Ear in a Mouse Model of Chronic Otitis Media with Effusion Induced by Combined Eustachian Tube Blockage and Nontypeable Haemophilus influenzae Infection.
Infection and immunity
Hirano T,Kodama S,Kawano T,Suzuki M
16-0251 was used in Functional assays to indicate that regulatory T-cells confer infectious tolerance to Nontypeable Haemophilus influenzae in the middle ear.
Fri Jan 01 00:00:00 EST 2016
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Molecular medicine reports
Gu L,Deng WS,Sun XF,Zhou H,Xu Q
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.
Autoimmunity
Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model.
Experimental and therapeutic medicine
Ruan G,Tao B,Wang D,Li Y,Wu J,Yin G
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sun May 15 00:00:00 EDT 2016
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nature communications
Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jun 21 00:00:00 EDT 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model.
Inflammation and regeneration
Tamura R,Uemoto S,Tabata Y
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Mar 31 00:00:00 EDT 2022
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.
International journal of obesity (2005)
Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
16-0251 was used in Flow cytometry/Cell sorting to identify a novel leukocyte receptor, TARM1, and investigate the mechanisms underlying its proinflammatory effects.
Thu Oct 01 00:00:00 EDT 2015
Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.
Endocrinology
Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA
16-0251 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.
Thu Oct 01 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
16-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 EST 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β.
BMC immunology
Wang X,Wang W,Xu J,Wu S,Le Q
16-0251 was used in Flow cytometry/Cell sorting to investigate the potential effect of the application of ATRA and TGF-β on immunological tolerance and the treatment of posttransplant rejection.
Thu Mar 19 00:00:00 EDT 2015
Oral Administration of Heat-Killed Mycobacterium manresensis Delays Progression toward Active Tuberculosis in C3HeB/FeJ Mice.
Frontiers in microbiology
Cardona P,Marzo-Escartín E,Tapia G,Díaz J,García V,Varela I,Vilaplana C,Cardona PJ
16-0251 was used in Functional assays to suggest that the use of heat-killed M. manresensis could be a new and promising tool for avoiding active TB induction and as adjunctive to TB treatment.
Mon Jan 18 00:00:00 EST 2016
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
16-0251 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jul 01 00:00:00 EDT 2014
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
PLoS pathogens
Le Saout C,Hasley RB,Imamichi H,Tcheung L,Hu Z,Luckey MA,Park JH,Durum SK,Smith M,Rupert AW,Sneller MC,Lane HC,Catalfamo M
16-0251 was used in Flow cytometry/Cell sorting to define the mechanisms behind immune cell maintenance in HIV infected individuals.
Sat Mar 01 00:00:00 EST 2014
γδ T cells restrain extrathymic development of Foxp3+-inducible regulatory T cells via IFN-γ.
European journal of immunology
Visperas A,Shen B,Min B
16-0251 was used in Flow cytometry/Cell sorting to reveal a novel function of γδ T cells in limiting the generation of iTreg cells, potentially balancing immunity and tolerance.
Fri Aug 01 00:00:00 EDT 2014
Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jul 15 00:00:00 EDT 2014
IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Lajoie S,Lewkowich I,Herman NS,Sproles A,Pesce JT,Wynn TA,Grusby MJ,Hamid Q,Wills-Karp M
16-0251 was used in Flow cytometry/Cell sorting to suggest that IL-21 plays an important role in the allergic diathesis by enhancing Th2 cytokine production through multiple mechanisms.
Tue Jul 01 00:00:00 EDT 2014
The regulatory T cells induction by epicutaneous immunotherapy is sustained and mediates long-term protection from eosinophilic disorders in peanut-sensitized mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Dioszeghy V,Mondoulet L,Dhelft V,Ligouis M,Puteaux E,Dupont C,Benhamou PH
16-0251 was used in Functional assays to suggest that EPIT induces long-term tolerance in peanut-sensitized mice.
Sun Jun 01 00:00:00 EDT 2014
A novel synthetic mycolic Acid inhibits bronchial hyperresponsiveness and allergic inflammation in a mouse model of asthma.
Allergy, asthma & immunology research
Kim YJ,Kim HJ,Jeong SK,Lee SH,Kang MJ,Yu HS,Jung YH,Seo JH,Kim BJ,Yu J,Park SJ,Lee YC,Hong SJ
16-0251 was used in in vivo experiments to observe the anti-inflammatory effects of a novel synthetic mycolic acid (sMA) in a mouse model of asthma.
Wed Jan 01 00:00:00 EST 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
Nature communications
Li Q,Zou J,Wang M,Ding X,Chepelev I,Zhou X,Zhao W,Wei G,Cui J,Zhao K,Wang HY,Wang RF
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
A dual role for autophagy in a murine model of lung cancer.
Nature communications
Rao S,Tortola L,Perlot T,Wirnsberger G,Novatchkova M,Nitsch R,Sykacek P,Frank L,Schramek D,Komnenovic V,Sigl V,Aumayr K,Schmauss G,Fellner N,Handschuh S,Glösmann M,Pasierbek P,Schlederer M,Resch GP,Ma Y,Yang H,Popper H,Kenner L,Kroemer G,Penninger JM
16-0251 was used in in vivo experiments to demonstrate that, in KRas(G12D)-driven lung cancer, Atg5-regulated autophagy accelerates tumour progression.
Tue Nov 24 00:00:00 EST 2015
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Nature immunology
Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ
16-0251 was used in Flow cytometry/Cell sorting to provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation.
Wed May 01 00:00:00 EDT 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2013
CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance.
American journal of physiology. Endocrinology and metabolism
Guo CA,Kogan S,Amano SU,Wang M,Dagdeviren S,Friedline RH,Aouadi M,Kim JK,Czech MP
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.
Vaccine
Beverley P,Ronan E,Lee L,Arnold I,Bolinger B,Powrie F,Tchilian E
16-0251 was used in Flow cytometry/Cell sorting to show that exposure to environmental microorganisms can alter the protective immune response to a parenterally administered subunit vaccine.
Mon Feb 04 00:00:00 EST 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes.
PloS one
Diaz-de-Durana Y,Lau J,Knee D,Filippi C,Londei M,McNamara P,Nasoff M,DiDonato M,Glynne R,Herman AE
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
16-0251 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 EDT 2014
Foxp3+ regulatory T cells are required for recovery from severe sepsis.
PloS one
Kühlhorn F,Rath M,Schmoeckel K,Cziupka K,Nguyen HH,Hildebrandt P,Hünig T,Sparwasser T,Huehn J,Pötschke C,Bröker BM
16-0251 was used in Flow cytometry/Cell sorting to determine the sufficiency of the suppressive capacity of Tregs for controlling inflammation due to sepsis.
Fri Jan 10 00:00:00 EST 2014
Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice.
PloS one
Schroder PM,Khattar M,Deng R,Xie A,Chen W,Stepkowski SM
16-0251 was used in Flow cytometry/Cell sorting to study the effect of transient anti-TCRB and anti-LFA1 mAb combination therapy on T cell responses and prolonged allograft survival in mice.
Thu Feb 20 00:00:00 EST 2014
Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants.
Blood
Hongo D,Tang X,Dutt S,Nador RG,Strober S
16-0251 was used in Functional assays to demonstrate that natural killer cells promote tolerance to organ grafts by regulating the expression of receptors and cytokines by Tregs.
Thu Feb 09 00:00:00 EST 2012
Interactions between NKT cells and Tregs are required for tolerance to combined bone marrow and organ transplants.
Blood
Hongo D,Tang X,Dutt S,Nador RG,Strober S
16-0251 was used in Functional assays to demonstrate that natural killer cells promote tolerance to organ grafts by regulating the expression of receptors and cytokines by Tregs.
Thu Feb 09 00:00:00 EST 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
16-0251 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
16-0251 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
16-0251 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
Peroxisome proliferator-activated receptor γ B cell-specific-deficient mice have an impaired antibody response.
Journal of immunology (Baltimore, Md. : 1950)
Ramon S,Bancos S,Thatcher TH,Murant TI,Moshkani S,Sahler JM,Bottaro A,Sime PJ,Phipps RP
16-0251 was used in Flow cytometry/Cell sorting to study how PPARγ expression in B cells is required for an efficient B cell-mediated immune response by regulating B cell differentiation and Ab production.
Thu Nov 15 00:00:00 EST 2012
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function.
Journal of immunology (Baltimore, Md. : 1950)
Sawant DV,Sehra S,Nguyen ET,Jadhav R,Englert K,Shinnakasu R,Hangoc G,Broxmeyer HE,Nakayama T,Perumal NB,Kaplan MH,Dent AL
16-0251 was used in Flow cytometry/Cell sorting to investigate the role of Bcl6 in Treg function.
Thu Nov 15 00:00:00 EST 2012
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
16-0251 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 EDT 2012
Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells.
The European respiratory journal
Preston JA,Thorburn AN,Starkey MR,Beckett EL,Horvat JC,Wade MA,O'Sullivan BJ,Thomas R,Beagley KW,Gibson PG,Foster PS,Hansbro PM
16-0251 was used in Flow cytometry/Cell sorting to identify the potential for the development of therapeutic agents for asthma from S. pneumoniae.
Sat Jan 01 00:00:00 EST 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
16-0251 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
16-0251 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Saba I,Kosan C,Vassen L,Klein-Hitpass L,Möröy T
16-0251 was used in Flow cytometry/Cell sorting to demonstrate the crucial role of the Miz-1 protein for the pre-T cell β-selection checkpoint.
Thu Sep 15 00:00:00 EDT 2011
An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene.
Molecular and cellular biology
Hosoya-Ohmura S,Lin YH,Herrmann M,Kuroha T,Rao A,Moriguchi T,Lim KC,Hosoya T,Engel JD
16-0251 was used in Flow cytometry/Cell sorting to show that neither of the Gata3 promoters is alone capable of directing Gata3 transcription in T lymphocytes.
Sun May 01 00:00:00 EDT 2011
Effect of CD4(+)CD25(+) regulatory T cells in the development of anterior chamber-associated immune deviation.
International journal of ophthalmology
Ji SX,Yin XL,Yang PZ
16-0251 was used in Functional assays to investigate whether CD4(+)CD25(+) regulatory T cells play a role in the development of anterior chamber-associated immune deviation.
Thu Aug 23 00:00:00 EDT 2012
Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
PloS one
Kar UK,Srivastava MK,Andersson A,Baratelli F,Huang M,Kickhoefer VA,Dubinett SM,Rome LH,Sharma S
16-0251 was used in Western Blotting to demonstrate that the vault nanocapsule can efficiently deliver CCL21 to recruit antitumour effectors, sustain antitumour activity and inhibit tumour growth.
Tue May 03 00:00:00 EDT 2011
Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells.
Blood
Coghill JM,Carlson MJ,Panoskaltsis-Mortari A,West ML,Burgents JE,Blazar BR,Serody JS
16-0251 was used in Flow cytometry/Cell sorting to investigate the role of MHC disparity between donor and recipient, in the attenuated graft-versus-host disease responses of murine T cells lacking CCR7.
Thu Jun 10 00:00:00 EDT 2010
Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions.
The Journal of experimental medicine
Fletcher AL,Lukacs-Kornek V,Reynoso ED,Pinner SE,Bellemare-Pelletier A,Curry MS,Collier AR,Boyd RL,Turley SJ
16-0251 was used in Flow cytometry/Cell sorting to study the lymph node stromal subsets responsible for presentation of peripheral tissue-restricted antigens to CD8+ T cells, showing that lymph node fibroblastic reticular cells are responsible for this under both steady-state and inflammatory conditions.
Mon Apr 12 00:00:00 EDT 2010
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.
Cancer research
Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G
16-0251 was used in Flow cytometry/Cell sorting to delineate the importance of IFNAR-dependent functions in TLR3-mediated tumour suppression.
Thu Apr 01 00:00:00 EDT 2010
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
Proceedings of the National Academy of Sciences of the United States of America
Humrich JY,Morbach H,Undeutsch R,Enghard P,Rosenberger S,Weigert O,Kloke L,Heimann J,Gaber T,Brandenburg S,Scheffold A,Huehn J,Radbruch A,Burmester GR,Riemekasten G
16-0251 was used in Neutralization experiments to demonstrate that impairment of the Treg-IL-2 axis induces a progressive homeostatic imbalance of Treg and effector Tcon.
Tue Jan 05 00:00:00 EST 2010
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.
Proceedings of the National Academy of Sciences of the United States of America
Ishikawa E,Miyake Y,Hara H,Saito T,Yamasaki S
16-0251 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying this ligand-independent pre-T-cell receptor (TCR) signalling in vivo, showing that germ-line elimination of electric charge on pre-T-cell receptor impairs autonomous signaling for beta-selection and TCR repertoire formation.
Tue Nov 16 00:00:00 EST 2010
Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand.
Immunology and cell biology
Petersen TR,Sika-Paotonu D,Knight DA,Dickgreber N,Farrand KJ,Ronchese F,Hermans IF
16-0251 was used in Neutralization experiments to investigate the impact of eliciting T-cell help from activated iNKT cells using alpha-galactosylceramide, showing potent anti-tumour response.
Thu Jul 01 00:00:00 EDT 2010
Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma.
Journal of immunology (Baltimore, Md. : 1950)
Anraku M,Tagawa T,Wu L,Yun Z,Keshavjee S,Zhang L,Johnston MR,de Perrot M
16-0251 was used in in vivo experiments to evaluate the potential of a combined Treg blockade-permetrexed anti-tumour treatment.
Thu Jul 15 00:00:00 EDT 2010
Attenuation of allergen-induced airway hyperresponsiveness is mediated by airway regulatory T cells.
American journal of physiology. Lung cellular and molecular physiology
Burchell JT,Wikstrom ME,Stumbles PA,Sly PD,Turner DJ
16-0251 was used in Functional assays to elucidate the cellular mechanisms involved in respiratory tolerance to inhaled allergens.
Sun Mar 01 00:00:00 EST 2009
Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis.
PloS one
Chan AS,Jensen KK,Skokos D,Doty S,Lederman HK,Kaplan RN,Rafii S,Rivella S,Lyden D
16-0251 was used in Flow cytometry/Cell sorting to identify Id1 as crucial for the dynamic cross-talk between bone and bone marrow haematopoietic cells.
Tue Nov 24 00:00:00 EST 2009
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
The Journal of experimental medicine
Sun CM,Hall JA,Blank RB,Bouladoux N,Oukka M,Mora JR,Belkaid Y
16-0251 was used in Flow cytometry/Cell sorting to investigate how the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
Mon Aug 06 00:00:00 EDT 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 EDT 2007
Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses.
Cancer research
Tuve S,Chen BM,Liu Y,Cheng TL,Touré P,Sow PS,Feng Q,Kiviat N,Strauss R,Ni S,Li ZY,Roffler SR,Lieber A
Fri Jun 15 00:00:00 EDT 2007
Dendritic cells program non-immunogenic prostate-specific T cell responses beginning at early stages of prostate tumorigenesis.
The Prostate
Mihalyo MA,Hagymasi AT,Slaiby AM,Nevius EE,Adler AJ
16-0251 was used in Neutralization experiments to suggest that tolerogenicity is an early and general property of prostate tumors.
Sun Apr 01 00:00:00 EDT 2007
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
Molecular and cellular biology
Dai X,Chen Y,Schuman J,Hua Z,Adamson JW,Wen R,Wang D
Published figure using CD25 monoclonal antibody (Product # 16-0251-85) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2006
Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment.
Proceedings of the National Academy of Sciences of the United States of America
Vosshenrich CA,Cumano A,Müller W,Di Santo JP,Vieira P
16-0251 was used in Flow cytometry/Cell sorting to study the biological activities of thymic stromal lymphopoietin in B cell development at distinct ages in the mouse.
Tue Jul 27 00:00:00 EDT 2004
Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements.
The Journal of experimental medicine
Oberdoerffer P,Novobrantseva TI,Rajewsky K
16-0251 was used in Flow cytometry/Cell sorting to demonstrate that expression of a VJ1-joint inserted into its position in the Ig locus is independent of Ig rearrangements.
Mon May 05 00:00:00 EDT 2003
