Product References
AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression.
Immunology
Cheng HH,Hung-Ke L,Sheu ML,Lee CY,Tsai YC,Lai DW
11-4776-42 was used in Flow Cytometry to provide novel insights for the development of therapeutic approaches for SLE and related autoimmune diseases.
Sat Apr 01 00:00:00 EDT 2023
EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis.
Arthritis research & therapy
Park JS,Yang SC,Jeong HY,Lee SY,Ryu JG,Choi JW,Kang HY,Kim SM,Hwang SH,Cho ML,Park SH
11-4776-42 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) to investigate the efficacy of EC-18 on the development of RA.
Thu Nov 17 00:00:00 EST 2022
Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity.
Nature communications
Piekarska K,Urban-Wójciuk Z,Kurkowiak M,Pelikant-Małecka I,Schumacher A,Sakowska J,Spodnik JH,Arcimowicz Ł,Zielińska H,Tymoniuk B,Renkielska A,Siebert J,Słomińska E,Trzonkowski P,Hupp T,Marek-Trzonkowska NM
11-4776-42 was used in Flow Cytometry to demonstrate that both direct and indirect contact with allogeneic ASCs improves therapeutic potential of Tregs (Regulatory T cells).
Mon Feb 14 00:00:00 EST 2022
P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.
Frontiers in immunology
Schall N,Talamini L,Wilhelm M,Jouvin-Marche E,Muller S
11-4776-42 was used in Flow cytometry/Cell sorting to suggest that P140 belongs to a new family of non-immunosuppressive immunoregulators that do not correct T and B cell abnormalities but rather contribute to the clearance of deleterious T and B cells.
Tue Jun 21 00:00:00 EDT 2022
SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
Heliyon
Singh Y,Trautwein C,Fendel R,Krickeberg N,Berezhnoy G,Bissinger R,Ossowski S,Salker MS,Casadei N,Riess O
11-4776-42 was used in Flow Cytometry to study the effects of SARS-CoV-2 virus infection on immune and metabolic functions in human cells.
Tue Jun 01 00:00:00 EDT 2021
Standardized 11-color flow cytometry panel for the functional phenotyping of human T regulatory cells.
Journal of biological methods
Manuszak C,Brainard M,Thrash E,Hodi FS,Severgnini M
11-4776 was used in Flow cytometry/Cell sorting to characterize Tregs and provide insight into their functional status and immunosuppressive capacity.
Mon Sep 28 00:00:00 EDT 2020
Effects of Desflurane and Sevoflurane anesthesia on regulatory T cells in patients undergoing living donor kidney transplantation: a randomized intervention trial.
BMC anesthesiology
Chutipongtanate A,Prukviwat S,Pongsakul N,Srisala S,Kamanee N,Arpornsujaritkun N,Gesprasert G,Apiwattanakul N,Hongeng S,Ittichaikulthol W,Sumethkul V,Chutipongtanate S
11-4776 was used in Flow cytometry/Cell sorting to investigate effects of desflurane and sevoflurane anesthesia on peripheral blood Tregs induction in patients undergoing living donor kidney transplantation.
Thu Aug 27 00:00:00 EDT 2020
Decreased effector regulatory T cells and increased activated CD4+ T cells in premature ovarian insufficiency.
American journal of reproductive immunology (New York, N.Y. : 1989)
Kobayashi M,Nakashima A,Yoshino O,Yoshie M,Ushijima A,Ito M,Ono Y,Shima T,Kawamura K,Ishizuka B,Saito S
11-4776-42 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) to examine the relationship between peripheral blood regulatory T (Treg) cells and autoantibodies in POI.
Sat Jun 01 00:00:00 EDT 2019
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells.
Nature immunology
Aschenbrenner D,Foglierini M,Jarrossay D,Hu D,Weiner HL,Kuchroo VK,Lanzavecchia A,Notarbartolo S,Sallusto F
11-4776 was used in Flow cytometry/Cell sorting to identify c-MAF as a relevant factor that drives two highly divergent post-activation fates of human TH17 cells.
Mon Oct 01 00:00:00 EDT 2018
Secretory High-Mobility Group Box 1 Protein Affects Regulatory T Cell Differentiation in Neuroblastoma Microenvironment In Vitro.
Journal of oncology
Vanichapol T,Chiangjong W,Panachan J,Anurathapan U,Chutipongtanate S,Hongeng S
11-4776 was used in Flow cytometry/Cell sorting to elucidate the role of the neuroblastoma microenvironment in promoting regulatory T cell phenotype.
Thu Oct 05 00:00:00 EDT 2023
CD8+ T cells with high TGF‑β1 expression cause lymph node fibrosis following HIV infection.
Molecular medicine reports
Huang L,Deng J,Xu W,Wang H,Shi L,Wu F,Wu D,Nei W,Zhao M,Mao P,Zhou X
11-4776-42 was used in Flow cytometry/Cell sorting to investigate the mechanism of LN fibrosis, the expression of transforming growth factor (TGF)‚β1 was determined in the LNs of HIV‚infected individuals by immunohistochemistry and fluorescence‚based flow cytometry.
Sun Jul 01 00:00:00 EDT 2018
Effect of TGF-β1 on blood CD4+CD25high regulatory T cell proliferation and Foxp3 expression during non-small cell lung cancer blood metastasis.
Experimental and therapeutic medicine
Hu Y,Qi W,Sun L,Zhou H,Zhou B,Yang Z
11-4776-42 was used in Flow Cytometry to provide a theoretical basis for the immunomodulatory processes during non-small cell lung cancer (NSCLC) blood metastasis.
Wed Aug 01 00:00:00 EDT 2018
Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis.
Nature communications
Kimura K,Hohjoh H,Fukuoka M,Sato W,Oki S,Tomi C,Yamaguchi H,Kondo T,Takahashi R,Yamamura T
11-4776 was used in Flow cytometry/Cell sorting to show that exosomal let-7i regulates MS pathogenesis by blocking the IGF1R/TGFBR1 pathway.
Tue Jan 02 00:00:00 EST 2018
Clinical significance of CCR7+CD8+ T cells in kidney transplant recipients with allograft rejection.
Scientific reports
Kim KW,Kim BM,Doh KC,Cho ML,Yang CW,Chung BH
11-4776 was used in Flow cytometry/Cell sorting to reveal the impact of CCR7+CD8+ T cells has on the proliferation and differentiation of T cells into effector cells in kidney transplant patients.
Mon Jun 11 00:00:00 EDT 2018
Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.
International journal of nanomedicine
Tomić S,Ilić N,Kokol V,Gruden-Movsesijan A,Mihajlović D,Bekić M,Sofronić-Milosavljević L,Čolić M,Vučević D
11-4776 was used in Flow cytometry/Cell sorting to investigate how differentially functionalised cellulose nanofibrils affect dendritic cell properties, their viability, morphology, differentiation and maturation potential, and the capacity to regulate T cell-mediated immune response.
Mon Dec 31 00:00:00 EST 2018
The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets.
Scandinavian journal of immunology
Albayati Z,Alyami A,Alomar S,Middleton D,Bonnett L,Aleem S,Flanagan BF,Christmas SE
11-4776-42 was used in Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin) to show that CMV influences HLA-G expression in healthy subjects and may contribute to viral immune evasion.
Wed Nov 01 00:00:00 EDT 2017
siRNA‑mediated knockdown of T‑bet and RORγt contributes to decreased inflammation in pre‑eclampsia.
Molecular medicine reports
Wang J,Wen ZQ,Cheng XY,Mei TY,Chen ZF,Su LX
11-4776-42 was used in Flow Cytometry to determine whether a decrease in the expression of T‚bet can restore immune balance and alleviate the systemic inflammatory response present in preeclampsia.
Wed Nov 01 00:00:00 EDT 2017
Protective effect of 1α,25-dihydroxyvitamin D3 on effector CD4+ T cell induced injury in human renal proximal tubular epithelial cells.
PloS one
Chung BH,Kim BM,Doh KC,Cho ML,Kim KW,Yang CW
11-4776 was used in Flow cytometry/Cell sorting to suggest that vitamin D may have a significant role in the regulation of inflammation in allograft tissue in kidney transplant recipients.
Mon Aug 28 00:00:00 EDT 2017
T cell subsets: an immunological biomarker to predict progression to clinical arthritis in ACPA-positive individuals.
Annals of the rheumatic diseases
Hunt L,Hensor EM,Nam J,Burska AN,Parmar R,Emery P,Ponchel F
11-4776 was used in Flow cytometry/Cell sorting to demonstrate how T cell subset dysregulation in Anticitrullinated protein antibody+ individuals predates the onset of inflammatory arthritis, and can predict risk of onset.
Sat Oct 01 00:00:00 EDT 2016
Differentiation of ICOS+ and ICOS- recent thymic emigrant regulatory T cells (RTE T regs) during normal pregnancy, pre-eclampsia and HELLP syndrome.
Clinical and experimental immunology
Wagner MI,Jöst M,Spratte J,Schaier M,Mahnke K,Meuer S,Zeier M,Steinborn A
11-4776 was used in Flow cytometry/Cell sorting to propose that regular differentiation of ICOS(+) and ICOS(-) CD45RA(+) CD31(+) RTE Tregs ensures a healthy pregnancy course and disturbed differentiation is associated with the occurrence of pre-eclampsia and HELLP syndrome.
Fri Jan 01 00:00:00 EST 2016
Safety and immunologic benefits of conversion to sirolimus in kidney transplant recipients with long-term exposure to calcineurin inhibitors.
The Korean journal of internal medicine
Yu JH,Kim KW,Kim BM,Chung BH,Cho ML,Choi BS,Park CW,Kim YS,Yang CW
11-4776 was used in Flow cytometry/Cell sorting to evaluate the safety and immunologic benefits of conversion to Sirolimus in stable kidney transplant recipients exposed to calcineurin inhibitors for long periods.
Sun May 01 00:00:00 EDT 2016
The role of interleukin-1 beta in the pathophysiology of Schnitzler's syndrome.
Arthritis research & therapy
de Koning HD,Schalkwijk J,Stoffels M,Jongekrijg J,Jacobs JF,Verwiel E,Koenen HJ,Preijers F,Holzinger D,Joosten I,van der Meer JW,Simon A
11-4776 was used in Flow cytometry/Cell sorting to examine the effect of in-vivo IL-1 inhibition on serum markers of inflammation and cellular immune responses.
Wed Jul 22 00:00:00 EDT 2015
Regulatory and Helper Follicular T Cells and Antibody Avidity to Simian Immunodeficiency Virus Glycoprotein 120.
Journal of immunology (Baltimore, Md. : 1950)
Blackburn MJ,Zhong-Min M,Caccuri F,McKinnon K,Schifanella L,Guan Y,Gorini G,Venzon D,Fenizia C,Binello N,Gordon SN,Miller CJ,Franchini G,Vaccari M
11-4776 was used in Flow cytometry/Cell sorting to demonstrate changes in the TFH/TFR ratio during chronic infection and suggest possible mechanisms for the unchecked expansion of TFH cells in HIV/SIV infection.
Thu Oct 01 00:00:00 EDT 2015
Increase of Th17 Cell Phenotype in Kidney Transplant Recipients with Chronic Allograft Dysfunction.
PloS one
Chung BH,Kim KW,Kim BM,Doh KC,Cho ML,Yang CW
11-4776 was used in Flow cytometry/Cell sorting to determine the association of Th17 cell phenotype with chronic allograft dysfunction, showing an increase in Th17 phenotype in kidney transplant recipients with allograft dysfunction.
Mon Jun 27 00:00:00 EDT 2016
Optimization of adipose tissue-derived mesenchymal stem cells by rapamycin in a murine model of acute graft-versus-host disease.
Stem cell research & therapy
Kim KW,Moon SJ,Park MJ,Kim BM,Kim EK,Lee SH,Lee EJ,Chung BH,Yang CW,Cho ML
11-4776 was used in Flow cytometry/Cell sorting to optimize the functional properties of MSCs to increase the protection for bone marrow transplantation recipients from the lethal acute graft-versus-host disease development.
Fri Oct 23 00:00:00 EDT 2015
Induction of Multiple Immune Regulatory Pathways with Differential Impact in HCV/HIV Coinfection.
Frontiers in immunology
Cho H,Kikuchi M,Li Y,Nakamoto N,Amorosa VK,Valiga ME,Chang KM
11-4776 was used in Flow cytometry/Cell sorting to examine the frequency, phenotype, and effector function of circulating T cell subsets in patients with chronic HCV and/or HIV infection.
Tue Jul 29 00:00:00 EDT 2014
Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.
Nature communications
Willmann KL,Klaver S,Doğu F,Santos-Valente E,Garncarz W,Bilic I,Mace E,Salzer E,Conde CD,Sic H,Májek P,Banerjee PP,Vladimer GI,Haskoloğlu S,Bolkent MG,Küpesiz A,Condino-Neto A,Colinge J,Superti-Furga G,Pickl WF,van Zelm MC,Eibel H,Orange JS,Ikincioğulları A,Boztuğ K
11-4776 was used in Flow cytometry/Cell sorting to study the effect of a biallelic mutation in the gene encoding NF-κB-inducing kinase on immune cell populations.
Wed Nov 19 00:00:00 EST 2014
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection.
Nature medicine
Park SH,Veerapu NS,Shin EC,Biancotto A,McCoy JP,Capone S,Folgori A,Rehermann B
11-4776 was used in Flow cytometry/Cell sorting to investigate the effect of subinfectious exposure to hepatitis C virus on T cell-mediated protection.
Sun Dec 01 00:00:00 EST 2013
Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells.
Blood
Peters JH,Koenen HJ,Fasse E,Tijssen HJ,Ijzermans JN,Groenen PJ,Schaap NP,Kwekkeboom J,Joosten I
11-4776 was used in Flow cytometry/Cell sorting to suggest that human secondary lymphoid organs aid in the maintenance and regulation of regulatory T-cell function and homeostasis.
Thu Sep 26 00:00:00 EDT 2013
Effects of adjuvant chemoradiotherapy on the frequency and function of regulatory T cells in patients with head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Schuler PJ,Harasymczuk M,Schilling B,Saze Z,Strauss L,Lang S,Johnson JT,Whiteside TL
11-4776 was used in Flow cytometry/Cell sorting to examine the effects of adjuvant chemoradiotherapy on regulatory T cell numbers and function in head and neck squamous cell carcinoma patients.
Sun Dec 01 00:00:00 EST 2013
The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells.
Neuro-oncology
Fang L,Lowther DE,Meizlish ML,Anderson RC,Bruce JN,Devine L,Huttner AJ,Kleinstein SH,Lee JY,Stern JN,Yaari G,Lovato L,Cronk KM,O'Connor KC
11-4776 was used in Flow cytometry/Cell sorting to study the phenotype and characteristics of infiltrating T and B cells that populate meningiomas.
Fri Nov 01 00:00:00 EDT 2013
Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients.
British journal of cancer
Jie HB,Gildener-Leapman N,Li J,Srivastava RM,Gibson SP,Whiteside TL,Ferris RL
11-4776 was used in Flow cytometry/Cell sorting to compare the immunosuppressive phenotypes and function of intratumoural Tregs with peripheral blood Tregs from head and neck squamous cell carcinoma patients.
Tue Nov 12 00:00:00 EST 2013
IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis.
Journal of immunology (Baltimore, Md. : 1950)
Younas M,Hue S,Lacabaratz C,Guguin A,Wiedemann A,Surenaud M,Beq S,Croughs T,Lelièvre JD,Lévy Y
11-4776 was used in Flow cytometry/Cell sorting to show that IL-7 negatively regulates human memory Tregs through CD39 down modulation leading to Th17 conversion.
Sun Sep 15 00:00:00 EDT 2013
CD4⁺CD73⁺ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression.
AIDS (London, England)
Schuler PJ,Macatangay BJ,Saze Z,Jackson EK,Riddler SA,Buchanan WG,Hilldorfer BB,Mellors JW,Whiteside TL,Rinaldo CR
11-4776 was used in Flow cytometry/Cell sorting to assess suppression of T-cell function by exogenous ADO and CD4+ CD73+ T cells.
Wed Jun 19 00:00:00 EDT 2013
Incomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment.
PloS one
Rueda CM,Velilla PA,Chougnet CA,Rugeles MT
11-4776 was used in Flow cytometry/Cell sorting to assess the frequency and phenotype of regulatory T-cells within CMV and HIV patients on different treatment regimes.
Tue Sep 23 00:00:00 EDT 2014
Suppression of tumour-specific CD4⁺ T cells by regulatory T cells is associated with progression of human colorectal cancer.
Gut
Betts G,Jones E,Junaid S,El-Shanawany T,Scurr M,Mizen P,Kumar M,Jones S,Rees B,Williams G,Gallimore A,Godkin A
11-4776 was used in Flow cytometry/Cell sorting to demonstrate that CRC presence drives the activity of Tregs and the suppression of CD4+ T-cell responses to tumour-associated antigens.
Wed Aug 01 00:00:00 EDT 2012
Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.
Blood
Chaidos A,Patterson S,Szydlo R,Chaudhry MS,Dazzi F,Kanfer E,McDonald D,Marin D,Milojkovic D,Pavlu J,Davis J,Rahemtulla A,Rezvani K,Goldman J,Roberts I,Apperley J,Karadimitris A
11-4776 was used in Flow cytometry/Cell sorting to demonstrate that higher doses of CD4 iNKT cells in PBSC grafts are associated with protection from aGVHD.
Thu May 24 00:00:00 EDT 2012
B cell-associated immune profiles in patients with end-stage renal disease (ESRD).
Experimental & molecular medicine
Kim KW,Chung BH,Jeon EJ,Kim BM,Choi BS,Park CW,Kim YS,Cho SG,Cho ML,Yang CW
11-4776 was used in Flow cytometry/Cell sorting to demonstrate significantly altered B cell-associated immunity.
Fri Aug 31 00:00:00 EDT 2012
Term and preterm labor: decreased suppressive activity and changes in composition of the regulatory T-cell pool.
Immunology and cell biology
Schober L,Radnai D,Schmitt E,Mahnke K,Sohn C,Steinborn A
11-4776 was used in Flow cytometry/Cell sorting to contrast the immune cell populations in women who gave birth prematurely and those who gave birth after the full term.
Thu Nov 01 00:00:00 EDT 2012
IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.
Journal of molecular medicine (Berlin, Germany)
Schilling B,Harasymczuk M,Schuler P,Egan JE,Whiteside TL
11-4776 was used in Flow cytometry/Cell sorting to show that IRX-2 favours IFN-γ-driven T cell polarization towards Teff cells and could be considered as a promising component of future antitumor therapies.
Wed Feb 01 00:00:00 EST 2012
Immunological parameters associated with the development of allergic rhinitis: a preliminary prospective study.
American journal of rhinology & allergy
Uekusa Y,Inamine A,Yonekura S,Horiguchi S,Fujimura T,Sakurai D,Yamamoto H,Suzuki H,Hanazawa T,Okamoto Y
11-4776 was used in Flow cytometry/Cell sorting to examine immunological titres in patients sensitised to cedar pollen but who have not developed pollinosis.
Fri Aug 17 00:00:00 EDT 2012
Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.
PloS one
Khoo AL,Koenen HJ,Chai LY,Sweep FC,Netea MG,van der Ven AJ,Joosten I
11-4776 was used in Flow cytometry/Cell sorting to reveal that seasonal fluctuations in vitamin D3 levels may partially explain seasonal variation in immune status.
Mon May 14 00:00:00 EDT 2012
DR(high+)CD45RA(-)-Tregs potentially affect the suppressive activity of the total Treg pool in renal transplant patients.
PloS one
Schaier M,Seissler N,Schmitt E,Meuer S,Hug F,Zeier M,Steinborn A
11-4776 was used in Flow cytometry/Cell sorting to demonstrate that the suppressive activity of the total Treg pool strongly depends on the presence of these Treg cells.
Fri Aug 03 00:00:00 EDT 2012
The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.
PloS one
Millrud CR,Månsson Kvarnhammar A,Uddman R,Björnsson S,Riesbeck K,Cardell LO
11-4776 was used in Flow cytometry/Cell sorting to characterise blood leukocyte activation in head and neck squamous cell carcinoma.
Tue Jun 11 00:00:00 EDT 2013
Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation.
Cellular immunology
Williams KM,Dotson AL,Otto AR,Kohlmeier JE,Benedict SH
11-4776 was used in Flow cytometry/Cell sorting to investigate the effects of costimulating surface proteins CD28 and ICAM-1 on naive T cell differentiation.
Fri Dec 02 00:00:00 EST 2011
Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets.
Journal of immunological methods
Schuler PJ,Harasymczuk M,Schilling B,Lang S,Whiteside TL
11-4776 was used in Flow cytometry/Cell sorting to investigate how CD4(+)CD39(+) Treg capture on immunobeads led to a discovery of two CD39(+) subsets.
Thu Jun 30 00:00:00 EDT 2011
Association between regulatory T cell activity and sepsis and outcome of severely burned patients: a prospective, observational study.
Critical care (London, England)
Huang LF,Yao YM,Dong N,Yu Y,He LX,Sheng ZY
11-4776 was used in Flow cytometry/Cell sorting to investigate the significance of changes in regulatory T cell activity, and its relationship with sepsis and patients with major burns.
Wed Sep 15 00:00:00 EDT 2010
In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction.
Proceedings of the National Academy of Sciences of the United States of America
Blatner NR,Bonertz A,Beckhove P,Cheon EC,Krantz SB,Strouch M,Weitz J,Koch M,Halverson AL,Bentrem DJ,Khazaie K
11-4776 was used in Flow cytometry/Cell sorting to identify that mast cells induce Treg to switch function and escalate inflammation in CRC without losing T-cell-suppressive properties.
Tue Apr 06 00:00:00 EDT 2010
Histone/protein deacetylase inhibitors increase suppressive functions of human FOXP3+ Tregs.
Clinical immunology (Orlando, Fla.)
Akimova T,Ge G,Golovina T,Mikheeva T,Wang L,Riley JL,Hancock WW
11-4776 was used in Flow cytometry/Cell sorting to investigate the effect of HDAC inhibitors on Tregs.
Wed Sep 01 00:00:00 EDT 2010
Gender specificity of altered human immune cytokine profiles in aging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Goetzl EJ,Huang MC,Kon J,Patel K,Schwartz JB,Fast K,Ferrucci L,Madara K,Taub DD,Longo DL
11-4776 was used in Flow cytometry/Cell sorting to study the gender specificity of altered human immune cytokine profiles in ageing.
Wed Sep 01 00:00:00 EDT 2010
Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2).
Journal of molecular medicine (Berlin, Germany)
Czystowska M,Strauss L,Bergmann C,Szajnik M,Rabinowich H,Whiteside TL
11-4776 was used in Flow cytometry/Cell sorting to investigate the sensitivity and resistance of Treg and RC to granzyme/perforin-mediated death.
Tue Jun 01 00:00:00 EDT 2010
Mechanisms of immune suppression for CD8+ T cells by human corneal endothelial cells via membrane-bound TGFbeta.
Investigative ophthalmology & visual science
Yamada Y,Sugita S,Horie S,Yamagami S,Mochizuki M
11-4776 was used in Flow cytometry/Cell sorting to determine whether CD8(+) T cells in vitro are suppressed or converted into regulators by human corneal endothelial cells.
Sat May 01 00:00:00 EDT 2010
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Biology of reproduction
Mjösberg J,Berg G,Jenmalm MC,Ernerudh J
11-4776 was used in Flow cytometry/Cell sorting to study the chemokine receptor expression profiles in human pregnancy decidua to monitor levels of TH1, TH2, TH17 and Treg cells.
Thu Apr 01 00:00:00 EDT 2010
CD4+ CD25+ Foxp3+ regulatory T cells, dendritic cells, and circulating cytokines in uncomplicated malaria: do different parasite species elicit similar host responses?
Infection and immunity
Gonçalves RM,Salmazi KC,Santos BA,Bastos MS,Rocha SC,Boscardin SB,Silber AM,Kallás EG,Ferreira MU,Scopel KK
11-4776 was used in Flow cytometry/Cell sorting to compare the differences in the immune responses induced by both Plasmodium falciparum and Plasmodium vivax.
Mon Nov 01 00:00:00 EDT 2010
CD25 appears non essential for human peripheral T(reg) maintenance in vivo.
PloS one
de Goër de Herve MG,Gonzales E,Hendel-Chavez H,Décline JL,Mourier O,Abbed K,Jacquemin E,Taoufik Y
11-4776 was used in Flow cytometry/Cell sorting to find that CD25 appears non essential for human T(reg) peripheral maintenance in vivo.
Fri Jul 30 00:00:00 EDT 2010
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death.
Blood
Mougiakakos D,Johansson CC,Kiessling R
11-4776 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying elevated numbers of Tregs in hematologic and solid malignancies.
Thu Apr 09 00:00:00 EDT 2009
Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation.
Science translational medicine
Davies JK,Nadler LM,Guinan EC
11-4776 was used in Flow cytometry/Cell sorting to showcase a methodology to preserve beneficial donor T cell effects while reducing graft-versus-host disease during transplantation.
Wed Oct 07 00:00:00 EDT 2009
Vaccine-specific local T cell reactivity in immunotherapy-associated vitiligo in melanoma patients.
Cancer immunology, immunotherapy : CII
Jacobs JF,Aarntzen EH,Sibelt LA,Blokx WA,Boullart AC,Gerritsen MJ,Hoogerbrugge PM,Figdor CG,Adema GJ,Punt CJ,de Vries IJ
11-4776 was used in Immunohistochemistry to show that functional CD8(+) T cells specific for melanoma differentiation antigens used in a melanoma immunotherapy trial, do not only invade the tumor, but also the vitiligo lesions.
Thu Jan 01 00:00:00 EST 2009
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Wang J,Huizinga TW,Toes RE
11-4776 was used in Flow cytometry/Cell sorting to investigate methods to convert T cells into Treg cells, showing that retinoic acid can be used for de novo generation of Tregs.
Tue Sep 15 00:00:00 EDT 2009
The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease.
Journal of immunology (Baltimore, Md. : 1950)
Wenink MH,Santegoets KC,Roelofs MF,Huijbens R,Koenen HJ,van Beek R,Joosten I,Meyer-Wentrup F,Mathsson L,Ronnelid J,Adema GJ,Bonvini E,Koenig S,van den Berg WB,van Riel PL,Radstake TR
11-4776 was used in Flow cytometry/Cell sorting to demonstrate role of inhibitory Fc gamma IIb receptor in the dampening of TLR4-mediated immune responses.
Thu Oct 01 00:00:00 EDT 2009
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Law JP,Hirschkorn DF,Owen RE,Biswas HH,Norris PJ,Lanteri MC
11-4776 was used in Flow cytometry/Cell sorting to develop a multiparameter flow cytometric panel with Foxp3 for optimal identification of Tregs.
Tue Dec 01 00:00:00 EST 2009
Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin.
PloS one
Strauss L,Czystowska M,Szajnik M,Mandapathil M,Whiteside TL
11-4776 was used in Flow cytometry/Cell sorting to study IL-2R-gamma chain signalling, survival pathways, resistance to apoptosis, and the expansion of human regulatory T cells responding to rapamycin.
Mon Jun 22 00:00:00 EDT 2009
CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients.
Cell cycle (Georgetown, Tex.)
Ju S,Qiu H,Zhou X,Zhu B,Lv X,Huang X,Li J,Zhang Y,Liu L,Ge Y,Johnson DE,Ju S,Shu Y
11-4776 was used in Flow cytometry/Cell sorting to study a subpopulation of CD4+CD25hiTreg cells in the peripheral blood of non-small cell lung cancer patients.
Sat Aug 15 00:00:00 EDT 2009
Safety and immunologic response of a viral vaccine to prostate-specific antigen in combination with radiation therapy when metronomic-dose interleukin 2 is used as an adjuvant.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lechleider RJ,Arlen PM,Tsang KY,Steinberg SM,Yokokawa J,Cereda V,Camphausen K,Schlom J,Dahut WL,Gulley JL
11-4776 was used in Flow cytometry/Cell sorting to assess the efficacy of IL-2 as a biological adjuvant in a prostate cancer vaccine.
Fri Aug 15 00:00:00 EDT 2008
Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Yokokawa J,Cereda V,Remondo C,Gulley JL,Arlen PM,Schlom J,Tsang KY
11-4776 was used in Flow cytometry/Cell sorting to compare the levels of Tregs in the peripheral blood of healthy donors and patients with various stages of prostate cancer.
Fri Feb 15 00:00:00 EST 2008
Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism.
Proceedings of the National Academy of Sciences of the United States of America
Esquerré M,Tauzin B,Guiraud M,Müller S,Saoudi A,Valitutti S
11-4776 was used in Flow cytometry/Cell sorting to identify a previously undescribed mechanism by which reguatory T-cells inhibit effector T-cells.
Tue Feb 19 00:00:00 EST 2008
Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Pascual J,Bloom D,Torrealba J,Brahmbhatt R,Chang Z,Sollinger HW,Knechtle SJ
11-4776 was used in Flow cytometry/Cell sorting to assess the results of calcineurin inhibitor withdrawal after alemtuzumab induction relative to calcineurin inhibitor continuation.
Tue Jul 01 00:00:00 EDT 2008
Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression.
Journal of immunology (Baltimore, Md. : 1950)
Strauss L,Bergmann C,Szczepanski MJ,Lang S,Kirkwood JM,Whiteside TL
11-4776-42 was used in Immunocytochemistry to show that ICOShigh Treg can induce diverse immune responses in RC, depending on activation signals and cytokines present. ICOShigh Treg induce Tr1 or Th2 cells depending on the activation state of RC. In a "Tr1" cytokine milieu, ICOShigh Treg transit to Tr1.
Sat Mar 01 00:00:00 EST 2008
Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus.
PloS one
Kreijveld E,Koenen HJ,van Cranenbroek B,van Rijssen E,Joosten I,Hilbrands LB
11-4776 was used in Flow cytometry/Cell sorting to identify a marker that would help to predict acute rejection following discontinuation of tacrolimus.
Wed Jul 16 00:00:00 EDT 2008
Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation.
PloS one
Peters JH,Preijers FW,Woestenenk R,Hilbrands LB,Koenen HJ,Joosten I
11-4776 was used in Flow cytometry/Cell sorting to demonstrate the high-purity isolation of Treg cells, and show that isolated cells can be cryopreserved and expanded successfully.
Mon Sep 08 00:00:00 EDT 2008
Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy.
PloS one
Tran TA,de Goër de Herve MG,Hendel-Chavez H,Dembele B,Le Névot E,Abbed K,Pallier C,Goujard C,Gasnault J,Delfraissy JF,Balazuc AM,Taoufik Y
11-4776 was used in Flow cytometry/Cell sorting to identify Tregs as a particular compartment within the latent HIV reservoir that may require a specific approach for its purging.
Wed Oct 01 00:00:00 EDT 2008
Expansion of CD4+CD25+ suppressive regulatory T cells from rhesus macaque peripheral blood by FN18/antihuman CD28-coated Dynal beads.
Human immunology
Gansuvd B,Asiedu CK,Goodwin J,Jargal U,Deckard LA,Andrades P,Guarcello V,Thomas JM
11-4776 was used in Flow cytometry/Cell sorting to demonstrate that rhesus macaque suppressive regulatory CD4(+)CD25(+)FOXP3(+) Tregs can be efficiently expanded in vitro under rhesus-specific stimulation.
Fri Jun 01 00:00:00 EDT 2007
Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells.
Blood
Coenen JJ,Koenen HJ,van Rijssen E,Hilbrands LB,Joosten I
11-4776 was used in Flow cytometry/Cell sorting to show that the differential effect of rapamycin and CsA on CD27+ T(REG) subset dominance may favour rapamycin in tolerance-inducing strategies.
Wed Feb 01 00:00:00 EST 2006
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Blood
Epple HJ,Loddenkemper C,Kunkel D,Tröger H,Maul J,Moos V,Berg E,Ullrich R,Schulzke JD,Stein H,Duchmann R,Zeitz M,Schneider T
Wed Nov 01 00:00:00 EST 2006
A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells.
Journal of the American Society of Nephrology : JASN
Lopez M,Clarkson MR,Albin M,Sayegh MH,Najafian N
11-4776 was used in Flow cytometry/Cell sorting to suggest that ATG may promote expansion and generation of regulatory T cells.
Sun Oct 01 00:00:00 EDT 2006
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Hillsamer P,Banham AH,Kim CH
Sat Oct 01 00:00:00 EDT 2005
