Product References
In chronic lymphocytic leukemia, activation of the thrombopoietin receptor promotes T-cell inhibitory properties, contributing to immunosuppression.
European journal of haematology
Ringelstein-Harlev S,Fanadka M,Horowitz NA,Bettman NP,Katz T
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Preventive effects of Mycobacterium tuberculosis DNA vaccines on the mouse model with latent tuberculosis infection.
Frontiers in immunology
Liang Y,Li X,Yang Y,Xiao L,Liang Y,Mi J,Xue Y,Gong W,Wang L,Wang J,Zhang J,Shi Y,Peng B,Chen X,Zhao W,Wu X
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Fri Mar 03 00:00:00 EST 2023
AHR/TET2/NT5E axis downregulation is associated with the risk of systemic lupus erythematosus and its progression.
Immunology
Cheng HH,Hung-Ke L,Sheu ML,Lee CY,Tsai YC,Lai DW
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.
Frontiers in oncology
Babl N,Hofbauer J,Matos C,Voll F,Menevse AN,Rechenmacher M,Mair R,Beckhove P,Herr W,Siska PJ,Renner K,Kreutz M,Schnell A
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2023
Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer.
JCI insight
Masuda K,Kornberg A,Miller J,Lin S,Suek N,Botella T,Secener KA,Bacarella AM,Cheng L,Ingham M,Rosario V,Al-Mazrou AM,Lee-Kong SA,Kiran RP,Stoeckius M,Smibert P,Del Portillo A,Oberstein PE,Sims PA,Yan KS,Han A
14-4776-82 was used in Immunohistochemistry to study the functional and phenotypic heterogeneity of T-cell infiltrates and their contribution to clinical outcomes in colorectal cancer using drpolet-based single cell RNA sequencing.
Fri Apr 08 00:00:00 EDT 2022
Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity.
Nature communications
Bradley D,Smith AJ,Blaszczak A,Shantaram D,Bergin SM,Jalilvand A,Wright V,Wyne KL,Dewal RS,Baer LA,Wright KR,Stanford KI,Needleman B,Brethauer S,Noria S,Renton D,Joseph JJ,Lovett-Racke A,Liu J,Hsueh WA
14-4776-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to study the mechanisms regulating adipose tissue regulatory T cells numbers in humans.
Sat Sep 24 00:00:00 EDT 2022
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19.
Cell reports. Medicine
Feyaerts D,Hédou J,Gillard J,Chen H,Tsai ES,Peterson LS,Ando K,Manohar M,Do E,Dhondalay GKR,Fitzpatrick J,Artandi M,Chang I,Snow TT,Chinthrajah RS,Warren CM,Wittman R,Meyerowitz JG,Ganio EA,Stelzer IA,Han X,Verdonk F,Gaudillière DK,Mukherjee N,Tsai AS,Rumer KK,Jacobsen DR,Bjornson-Hooper ZB,Jiang S,Saavedra SF,Valdés Ferrer SI,Kelly JD,Furman D,Aghaeepour N,Angst MS,Boyd SD,Pinsky BA,Nolan GP,Nadeau KC,Gaudillière B,McIlwain DR
14-4776-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for prevention and/or treatment of COVID-19 progression.
Tue Jul 19 00:00:00 EDT 2022
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Immunity
Schwabenland M,Salié H,Tanevski J,Killmer S,Lago MS,Schlaak AE,Mayer L,Matschke J,Püschel K,Fitzek A,Ondruschka B,Mei HE,Boettler T,Neumann-Haefelin C,Hofmann M,Breithaupt A,Genc N,Stadelmann C,Saez-Rodriguez J,Bronsert P,Knobeloch KP,Blank T,Thimme R,Glatzel M,Prinz M,Bengsch B
14-4776-82 was used in Mass cytometry to identify profound neuroinflammation with activation of innate and adaptive immune cells as correlates of COVID-19 neuropathology, with implications for potential therapeutic strategies.
Tue Jul 13 00:00:00 EDT 2021
FABP4 facilitates inflammasome activation to induce the Treg/Th17 imbalance in preeclampsia via forming a positive feedback with IL-17A.
Molecular therapy. Nucleic acids
Chang GP,Yang XL,Liu W,Lin S,Yang SL,Zhao MY
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Fri Jun 04 00:00:00 EDT 2021
VX-765 reduces neuroinflammation after spinal cord injury in mice.
Neural regeneration research
Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Wed Sep 01 00:00:00 EDT 2021
VX-765 reduces neuroinflammation after spinal cord injury in mice.
Neural regeneration research
Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Wed Sep 01 00:00:00 EDT 2021
Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
Molecular medicine reports
You Y,Huang S,Liu H,Fan C,Liu K,Wang Z
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Sun Aug 01 00:00:00 EDT 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Ex vivo expansion of dysfunctional regulatory T lymphocytes restores suppressive function in Parkinson's disease.
NPJ Parkinson's disease
Thome AD,Atassi F,Wang J,Faridar A,Zhao W,Thonhoff JR,Beers DR,Lai EC,Appel SH
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Thu May 13 00:00:00 EDT 2021
Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis.
Frontiers in immunology
Wang W,Wang X,Lu S,Lv H,Zhao T,Xie G,Du Y,Fan Y,Xu L
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed Oct 20 00:00:00 EDT 2021
SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells.
Heliyon
Singh Y,Trautwein C,Fendel R,Krickeberg N,Berezhnoy G,Bissinger R,Ossowski S,Salker MS,Casadei N,Riess O
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Unmasking the immune microecology of ductal carcinoma in situ with deep learning.
NPJ breast cancer
Narayanan PL,Raza SEA,Hall AH,Marks JR,King L,West RB,Hernandez L,Guppy N,Dowsett M,Gusterson B,Maley C,Hwang ES,Yuan Y
14-4776-82 was used in Immunohistochemistry to demonstrate that technological developments in deep convolutional neural networks and digital pathology can enable an automated morphological and microenvironmental analysis of DCIS, providing a new way to study differential immune ecology for individual ducts and identify new markers of progression.
Mon Mar 01 00:00:00 EST 2021
Unmasking the immune microecology of ductal carcinoma in situ with deep learning.
NPJ breast cancer
Narayanan PL,Raza SEA,Hall AH,Marks JR,King L,West RB,Hernandez L,Guppy N,Dowsett M,Gusterson B,Maley C,Hwang ES,Yuan Y
14-4776-82 was used in Immunohistochemistry to demonstrate that technological developments in deep convolutional neural networks and digital pathology can enable an automated morphological and microenvironmental analysis of DCIS, providing a new way to study differential immune ecology for individual ducts and identify new markers of progression.
Mon Mar 01 00:00:00 EST 2021
Microbial exposure during early human development primes fetal immune cells.
Cell
Mishra A,Lai GC,Yao LJ,Aung TT,Shental N,Rotter-Maskowitz A,Shepherdson E,Singh GSN,Pai R,Shanti A,Wong RMM,Lee A,Khyriem C,Dutertre CA,Chakarov S,Srinivasan KG,Shadan NB,Zhang XM,Khalilnezhad S,Cottier F,Tan ASM,Low G,Chen P,Fan Y,Hor PX,Lee AKM,Choolani M,Vermijlen D,Sharma A,Fuks G,Straussman R,Pavelka N,Malleret B,McGovern N,Albani S,Chan JKY,Ginhoux F
14-4776-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to indicate selective presence of live microbes in fetal organs during the 2nd trimester of gestation and have broader implications toward the establishment of immune competency and priming before birth.
Thu Jun 24 00:00:00 EDT 2021
Viable bacterial colonization is highly limited in the human intestine in utero.
Nature medicine
Rackaityte E,Halkias J,Fukui EM,Mendoza VF,Hayzelden C,Crawford ED,Fujimura KE,Burt TD,Lynch SV
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques - an experimental study.
Transplant international : official journal of the European Society for Organ Transplantation
Berglund E,Alonso-Guallart P,Danton M,Sellberg F,Binder C,Fröbom R,Berglund D,Llore N,Sakai H,Iuga A,Ekanayake-Alper D,Reimann KA,Sachs DH,Sykes M,Griesemer A
14-4776-82 was used in Flow Cytometry to report the safety profile and efficacy of two modifications of the same anti-CD2 monoclonal antibody in cynomolgus macaques.
Wed Jan 01 00:00:00 EST 2020
Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal Cancer.
Cell reports. Medicine
Li S,Simoni Y,Becht E,Loh CY,Li N,Lachance D,Koo SL,Lim TP,Tan EKW,Mathew R,Nguyen A,Golovato J,Berkson JD,Prlic M,Lee B,Minot SS,Nagarajan N,Dey N,Tan DSW,Tan IB,Newell EW
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Jun 23 00:00:00 EDT 2020
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.
JCI insight
Henderson LA,Hoyt KJ,Lee PY,Rao DA,Jonsson AH,Nguyen JP,Rutherford K,Julé AM,Charbonnier LM,Case S,Chang MH,Cohen EM,Dedeoglu F,Fuhlbrigge RC,Halyabar O,Hazen MM,Janssen E,Kim S,Lo J,Lo MS,Meidan E,Son MBF,Sundel RP,Stoll ML,Nusbaum C,Lederer JA,Chatila TA,Nigrovic PA
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Thu Mar 26 00:00:00 EDT 2020
CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.
Journal of neuroinflammation
Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ
14-4776-82 was used in Immunohistochemistry (Frozen) to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.
Sat Aug 29 00:00:00 EDT 2020
Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer.
Cancers
Bauman JE,Ohr J,Gooding WE,Ferris RL,Duvvuri U,Kim S,Johnson JT,Soloff AC,Wallweber G,Winslow J,Gaither-Davis A,Grandis JR,Stabile LP
14-4776-82 was used in Flow Cytometry to establish the recommended Phase II dose (RP2D). Secondary objectives included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).
Thu Jun 11 00:00:00 EDT 2020
Proinflammatory and regulatory mechanisms in allergic contact dermatitis caused by methylchloroisothiazolinone and methylisothiazolinone.
Experimental dermatology
Goes HFO,Virgens AR,de Carvalho GC,Pietrobon AJ,Branco ACCC,Oliveira LMDS,Fernandes IG,Pereira NV,Sotto MN,Dos Reis VMS,Sato MN
14-4776-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to indicate that the regulatory process at the induction phase of ACD is a crucial mechanism.
Fri May 01 00:00:00 EDT 2020
T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.
Investigative ophthalmology & visual science
Yang X,Zeng Q,Göktas E,Gopal K,Al-Aswad L,Blumberg DM,Cioffi GA,Liebmann JM,Tezel G
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2019
Umbilical cord blood‑derived Helios‑positive regulatory T cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway.
Molecular medicine reports
Li X,Li D,Shi Q,Huang X,Ju X
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma.
Nature communications
Tian D,Yang L,Wang S,Zhu Y,Shi W,Zhang C,Jin H,Tian Y,Xu H,Sun G,Liu K,Zhang Z,Zhang D
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed Sep 18 00:00:00 EDT 2019
Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
JCI insight
Dawson NA,Lamarche C,Hoeppli RE,Bergqvist P,Fung VC,McIver E,Huang Q,Gillies J,Speck M,Orban PC,Bush JW,Mojibian M,Levings MK
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Thu Mar 21 00:00:00 EDT 2019
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.
Oncoimmunology
Triulzi T,Forte L,Regondi V,Di Modica M,Ghirelli C,Carcangiu ML,Sfondrini L,Balsari A,Tagliabue E
14-4776 was used in Immunohistochemistry to investigate the relationship between HER2 activity and the pro-trastuzumab tumour immune milieu.
Tue Jan 12 00:00:00 EST 2021
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.
Oncoimmunology
Triulzi T,Forte L,Regondi V,Di Modica M,Ghirelli C,Carcangiu ML,Sfondrini L,Balsari A,Tagliabue E
14-4776 was used in Immunohistochemistry to investigate the relationship between HER2 activity and the pro-trastuzumab tumour immune milieu.
Tue Jan 12 00:00:00 EST 2021
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Scientific reports
Wang Z,Sun K,Xiao Y,Feng B,Mikule K,Ma X,Feng N,Vellano CP,Federico L,Marszalek JR,Mills GB,Hanke J,Ramaswamy S,Wang J
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Feb 12 00:00:00 EST 2019
Lymphoid Aggregates in the CNS of Progressive Multiple Sclerosis Patients Lack Regulatory T Cells.
Frontiers in immunology
Bell L,Lenhart A,Rosenwald A,Monoranu CM,Berberich-Siebelt F
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunofluorescence
Thu Oct 22 00:00:00 EDT 2020
Lymphoid Aggregates in the CNS of Progressive Multiple Sclerosis Patients Lack Regulatory T Cells.
Frontiers in immunology
Bell L,Lenhart A,Rosenwald A,Monoranu CM,Berberich-Siebelt F
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunofluorescence
Thu Oct 22 00:00:00 EDT 2020
Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.
Cellular and molecular gastroenterology and hepatology
Bamidele AO,Svingen PA,Sagstetter MR,Sarmento OF,Gonzalez M,Braga Neto MB,Kugathasan S,Lomberk G,Urrutia RA,Faubion WA
14-4776 was used in Western Blotting to study whether a physical interaction between FOXP3 and the epigenetic enzyme enhancer of zeste homologue 2 is essential for gene co-repressive function.
Mon Apr 29 00:00:00 EDT 2019
Tumor Characteristics Associated with Benefit from Pembrolizumab in Advanced Non-Small Cell Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hu-Lieskovan S,Lisberg A,Zaretsky JM,Grogan TR,Rizvi H,Wells DK,Carroll J,Cummings A,Madrigal J,Jones B,Gukasyan J,Shintaku IP,Slamon D,Dubinett S,Goldman JW,Elashoff D,Hellmann MD,Ribas A,Garon EB
14-4776-82 was used in Immunohistochemistry to assess the association between baseline tumor characteristics (TMB, PD-L1, CD4, and CD8) and clinical features and outcome in 38 patients with advanced NSCLC treated with pembrolizumab (median follow-up of 4.5 years, range 3.8-5.5 years).
Thu Aug 15 00:00:00 EDT 2019
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody.
Oncoimmunology
Dao T,Mun SS,Scott AC,Jarvis CA,Korontsvit T,Yang Z,Liu L,Klatt MG,Guerreiro M,Selvakumar A,Brea EJ,Oh C,Liu C,Scheinberg DA
14-4776-82 was used in Flow cytometry/Cell sorting to generate a T cell receptor mimic antibody, "Foxp3-#32," recognizing a Foxp3-derived epitope in the context of HLA-A*02:01.
Tue May 09 00:00:00 EDT 2023
Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.
Frontiers in immunology
Di Giovangiulio M,Rizzo A,Franzè E,Caprioli F,Facciotti F,Onali S,Favale A,Stolfi C,Fehling HJ,Monteleone G,Fantini MC
14-4776-82 was used in Flow Cytometry to investigate the functional role of T helper type 1-like Tregs in the dextran sulfate model of colitis.
Wed Oct 21 00:00:00 EDT 2020
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
Cancer cell
Arce Vargas F,Furness AJS,Litchfield K,Joshi K,Rosenthal R,Ghorani E,Solomon I,Lesko MH,Ruef N,Roddie C,Henry JY,Spain L,Ben Aissa A,Georgiou A,Wong YNS,Smith M,Strauss D,Hayes A,Nicol D,O'Brien T,Mårtensson L,Ljungars A,Teige I,Frendéus B,Pule M,Marafioti T,Gore M,Larkin J,Turajlic S,Swanton C,Peggs KS,Quezada SA
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Apr 09 00:00:00 EDT 2018
Immune rebound associates with a favorable clinical response to autologous HSCT in systemic sclerosis patients.
Blood advances
Arruda LCM,Malmegrim KCR,Lima-Júnior JR,Clave E,Dias JBE,Moraes DA,Douay C,Fournier I,Moins-Teisserenc H,Alberdi AJ,Covas DT,Simões BP,Lansiaux P,Toubert A,Oliveira MC
14-4776 was used in Flow cytometry/Cell sorting to evaluate the immunological mechanisms associated with clinical outcomes after autologous hematopoietic stem cell transplantation (AHSCT), focusing on regulatory T- (Treg) and B- (Breg) cell immune reconstitution, 31 systemic sclerosis (SSc) patients underwent simultaneous clinical and immunological evaluations over 36-month posttransplantation follow-up.
Tue Jan 23 00:00:00 EST 2018
Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Chambers ES,Nanzer AM,Pfeffer PE,Richards DF,Martineau AR,Griffiths CJ,Corrigan CJ,Hawrylowicz CM
14-4776 was used in Flow cytometry/Cell sorting to determine whether clinical glucocorticoid sensitivity of severe asthmatics is reflected in differences in peripheral blood dendritic cell subsets.
Mon Jan 01 00:00:00 EST 2018
Analysis of immunobiologic markers in primary and recurrent glioblastoma.
Journal of neuro-oncology
Rahman M,Kresak J,Yang C,Huang J,Hiser W,Kubilis P,Mitchell D
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Sun Apr 01 00:00:00 EDT 2018
Analysis of immunobiologic markers in primary and recurrent glioblastoma.
Journal of neuro-oncology
Rahman M,Kresak J,Yang C,Huang J,Hiser W,Kubilis P,Mitchell D
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Sun Apr 01 00:00:00 EDT 2018
Induction of porcine-specific regulatory T cells with high specificity and expression of IL-10 and TGF-β1 using baboon-derived tolerogenic dendritic cells.
Xenotransplantation
Li M,Eckl J,Abicht JM,Mayr T,Reichart B,Schendel DJ,Pohla H
14-4776 was used in Flow cytometry/Cell sorting to generate baboon-derived tolerogenic dendritic cells that allow subsequent induction of porcine-specific Treg cells displaying high porcine-antigen specificity and expression of IL-10 and TGF-β1.
Mon Jan 01 00:00:00 EST 2018
CD8+ T cells with high TGF‑β1 expression cause lymph node fibrosis following HIV infection.
Molecular medicine reports
Huang L,Deng J,Xu W,Wang H,Shi L,Wu F,Wu D,Nei W,Zhao M,Mao P,Zhou X
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Sun Jul 01 00:00:00 EDT 2018
Effect of TGF-β1 on blood CD4+CD25high regulatory T cell proliferation and Foxp3 expression during non-small cell lung cancer blood metastasis.
Experimental and therapeutic medicine
Hu Y,Qi W,Sun L,Zhou H,Zhou B,Yang Z
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed Jan 31 00:00:00 EST 2018
Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma.
Oncoimmunology
Bajor DL,Mick R,Riese MJ,Huang AC,Sullivan B,Richman LP,Torigian DA,George SM,Stelekati E,Chen F,Melenhorst JJ,Lacey SF,Xu X,Wherry EJ,Gangadhar TC,Amaravadi RK,Schuchter LM,Vonderheide RH
14-4776 was used in Flow cytometry/Cell sorting to report long-term clinical outcomes and immune responses observed from a phase 1 trial of agonist CD40 monoclonal antibody and blocking CTLA-4 mAb in patients with metastatic melanoma.
Tue Jan 12 00:00:00 EST 2021
Intradermal injection of low dose human regulatory T cells inhibits skin inflammation in a humanized mouse model.
Scientific reports
Landman S,de Oliveira VL,van Erp PEJ,Fasse E,Bauland SCG,Joosten I,Koenen HJPM
14-4776 was used in Immunohistochemistry to evaluate if local delivery of low numbers of human regulatory T cells by intradermal injection prevents skin inflammation in the humanised mouse huPBL-SCID-huSkin allograft model.
Tue Jul 03 00:00:00 EDT 2018
Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis.
Nature communications
Gaddis DE,Padgett LE,Wu R,McSkimming C,Romines V,Taylor AM,McNamara CA,Kronenberg M,Crotty S,Thomas MJ,Sorci-Thomas MG,Hedrick CC
14-4776 was used in Flow cytometry/Cell sorting to deduce that modulation of the cellular fate of Treg cells and the resulting influence on the immune response during atherosclerosis is due to Apolipoprotein AI.
Thu Mar 15 00:00:00 EDT 2018
OX40L/OX40 axis impairs follicular and natural Treg function in human SLE.
JCI insight
Jacquemin C,Augusto JF,Scherlinger M,Gensous N,Forcade E,Douchet I,Levionnois E,Richez C,Lazaro E,Duffau P,Truchetet ME,Seneschal J,Couzi L,Pellegrin JL,Viallard JF,Schaeverbeke T,Pascual V,Contin-Bordes C,Blanco P
14-4776 was used in Immunohistochemistry-immunofluorescence to study the mechanisms respsonsible for the Treg deficiency in systemic lupus erythematosus.
Thu Dec 20 00:00:00 EST 2018
Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.
Cell research
Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Boardman DA,Philippeos C,Fruhwirth GO,Ibrahim MA,Hannen RF,Cooper D,Marelli-Berg FM,Watt FM,Lechler RI,Maher J,Smyth LA,Lombardi G
14477682 was used in flow cytometry to observe that the use of chimeric antigen receptor technology is a clinically applicable refinement of regulatory T cell therapy for organ transplantation
Sat Apr 01 00:00:00 EDT 2017
A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.
Frontiers in immunology
García-Hernández ML,Uribe-Uribe NO,Espinosa-González R,Kast WM,Khader SA,Rangel-Moreno J
14-4776 was used in Immunofluorescence to suggest that COX2 and Treg are attractive therapeutic targets that can enhance TLO-driven tumor immunity against prostate cancer.
Wed Nov 20 00:00:00 EST 2019
Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1.
Journal of virology
Miller SM,Miles B,Guo K,Folkvord J,Meditz AL,McCarter MD,Levy DN,MaWhinney S,Santiago ML,Connick E
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Fri Sep 01 00:00:00 EDT 2017
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
Clinical and experimental immunology
Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH
14477682 was used in flow cytometry to examine the potential of IL-2 to enhance T regulatory cell therapy
Thu Jun 01 00:00:00 EDT 2017
Cutting Edge: Increased Autoimmunity Risk in Glycogen Storage Disease Type 1b Is Associated with a Reduced Engagement of Glycolysis in T Cells and an Impaired Regulatory T Cell Function.
Journal of immunology (Baltimore, Md. : 1950)
Melis D,Carbone F,Minopoli G,La Rocca C,Perna F,De Rosa V,Galgani M,Andria G,Parenti G,Matarese G
14477682 was used in western blot to examine the effect of glucose-6-phosphate transporter mutation on immune cell homeostasis and CD4+ T cell functions
Mon May 15 00:00:00 EDT 2017
Therapeutic immune monitoring of CD4+CD25+ T cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors.
Oncology letters
Lu Z,Xu N,Zhou X,Gao G,Li L,Huang J,Li Y,Lu Q,He B,Pan C,Liu X
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Alteration of Th17 and Foxp3+ regulatory T cells in patients with unexplained recurrent spontaneous abortion before and after the therapy of hCG combined with immunoglobulin.
Experimental and therapeutic medicine
Sha J,Liu F,Zhai J,Liu X,Zhang Q,Zhang B
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
Kim JM,Kwon CHD,Joh JW,Sinn DH,Choi GS,Park JB,Kang ES,Lee SK
14477682 was used in flow cytometry to characterize the periferal blood lymphocytes phenotype in tacrolimus-treated liver transplanted patients.
Mon Mar 19 00:00:00 EDT 2018
HDAC inhibition potentiates immunotherapy in triple negative breast cancer.
Oncotarget
Terranova-Barberio M,Thomas S,Ali N,Pawlowska N,Park J,Krings G,Rosenblum MD,Budillon A,Munster PN
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue Dec 26 00:00:00 EST 2017
Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment.
Oncotarget
Syed Khaja AS,Toor SM,El Salhat H,Faour I,Ul Haq N,Ali BR,Elkord E
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue May 16 00:00:00 EDT 2017
Serial immunomonitoring of cancer patients receiving combined antagonistic anti-CD40 and chemotherapy reveals consistent and cyclical modulation of T cell and dendritic cell parameters.
BMC cancer
McDonnell AM,Cook A,Robinson BWS,Lake RA,Nowak AK
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Thu Jun 15 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis.
The Journal of clinical investigation
Cheng HY,Gaddis DE,Wu R,McSkimming C,Haynes LD,Taylor AM,McNamara CA,Sorci-Thomas M,Hedrick CC
14-4776 was used in Flow cytometry/Cell sorting to indicate that ABCG1 regulates T cell differentiation into Tregs, highlighting a pathway by which cholesterol accumulation can influence T cell homeostasis in atherosclerosis.
Thu Sep 01 00:00:00 EDT 2016
Pulmonary sarcoidosis is associated with high-level inducible co-stimulator (ICOS) expression on lung regulatory T cells--possible implications for the ICOS/ICOS-ligand axis in disease course and resolution.
Clinical and experimental immunology
Sakthivel P,Grunewald J,Eklund A,Bruder D,Wahlström J
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Younis RH,Han KL,Webb TJ
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Development of Type 2, But Not Type 1, Leprosy Reactions is Associated with a Severe Reduction of Circulating and In situ Regulatory T-Cells.
The American journal of tropical medicine and hygiene
Vieira AP,Trindade MÂ,Pagliari C,Avancini J,Sakai-Valente NY,Duarte AJ,Benard G
Fri Apr 01 00:00:00 EDT 2016
Development of Type 2, But Not Type 1, Leprosy Reactions is Associated with a Severe Reduction of Circulating and In situ Regulatory T-Cells.
The American journal of tropical medicine and hygiene
Vieira AP,Trindade MÂ,Pagliari C,Avancini J,Sakai-Valente NY,Duarte AJ,Benard G
Fri Apr 01 00:00:00 EDT 2016
Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.
Experimental and therapeutic medicine
Zhao J,Ma J,Zhang X,Li Q,Yang X
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis.
Journal of clinical research in pediatric endocrinology
Şıklar Z,Karataş D,Doğu F,Hacıhamdioğlu B,İkincioğulları A,Berberoğlu M
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin.
Medicine
Legorreta-Haquet MV,Chávez-Rueda K,Chávez-Sánchez L,Cervera-Castillo H,Zenteno-Galindo E,Barile-Fabris L,Burgos-Vargas R,Álvarez-Hernández E,Blanco-Favela F
14477682 was used in flow cytometry to examine the relationship between prolactin and T regulatory cells in patients with systemic lupus erythematosus
Mon Feb 01 00:00:00 EST 2016
The prognostic effects of tumor infiltrating regulatory T cells and myeloid derived suppressor cells assessed by multicolor flow cytometry in gastric cancer patients.
Oncotarget
Choi HS,Ha SY,Kim HM,Ahn SM,Kang MS,Kim KM,Choi MG,Lee JH,Sohn TS,Bae JM,Kim S,Kang ES
14-4776 was used in Flow cytometry/Cell sorting to demonstrate that in gastric cancer, a high frequency of Tregs among tumour-infiltrating CD4+ T cells is favourable, but an increased proportion of MDSCs is an adverse independent prognostic factor.
Tue Feb 16 00:00:00 EST 2016
Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells.
Oncoimmunology
Seebauer CT,Brunner S,Glockzin G,Piso P,Ruemmele P,Schlitt HJ,Geissler EK,Fichtner-Feigl S,Kesselring R
14-4776 was used in Immunohistochemistry to characterise the immunological tumour microenvironment in proliferation, senescence and neovascularization.
Tue Jan 12 00:00:00 EST 2021
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
JCI insight
Seay HR,Yusko E,Rothweiler SJ,Zhang L,Posgai AL,Campbell-Thompson M,Vignali M,Emerson RO,Kaddis JS,Ko D,Nakayama M,Smith MJ,Cambier JC,Pugliese A,Atkinson MA,Robins HS,Brusko TM
14-4776 was used in Immunohistochemistry to assess the tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes.
Thu Dec 08 00:00:00 EST 2016
Activation of myeloid dendritic cells, effector cells and regulatory T cells in lichen planus.
Journal of translational medicine
Domingues R,de Carvalho GC,Aoki V,da Silva Duarte AJ,Sato MN
14-4776 was used in Flow cytometry/Cell sorting to identify that TLR activation has an adjuvant role in inducing both innate and adaptive immune responses.
Fri Jun 10 00:00:00 EDT 2016
PD-1 marks dysfunctional regulatory T cells in malignant gliomas.
JCI insight
Lowther DE,Goods BA,Lucca LE,Lerner BA,Raddassi K,van Dijk D,Hernandez AL,Duan X,Gunel M,Coric V,Krishnaswamy S,Love JC,Hafler DA
14-4776 was used in Flow cytometry/Cell sorting to study how high PD-1 expression on human Tregs identifies dysfunctional, exhausted Tregs secreting IFN-γ that exist in healthy individuals and are enriched in tumor infiltrates.
Thu Apr 21 00:00:00 EDT 2016
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
Nature immunology
De Rosa V,Galgani M,Porcellini A,Colamatteo A,Santopaolo M,Zuchegna C,Romano A,De Simone S,Procaccini C,La Rocca C,Carrieri PB,Maniscalco GT,Salvetti M,Buscarinu MC,Franzese A,Mozzillo E,La Cava A,Matarese G
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Western Blot
Sun Nov 01 00:00:00 EDT 2015
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
Nature immunology
De Rosa V,Galgani M,Porcellini A,Colamatteo A,Santopaolo M,Zuchegna C,Romano A,De Simone S,Procaccini C,La Rocca C,Carrieri PB,Maniscalco GT,Salvetti M,Buscarinu MC,Franzese A,Mozzillo E,La Cava A,Matarese G
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Western Blot
Sun Nov 01 00:00:00 EDT 2015
Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Weed DT,Vella JL,Reis IM,De la Fuente AC,Gomez C,Sargi Z,Nazarian R,Califano J,Borrello I,Serafini P
14477682 was used in flow cytometry to study the immune effects of tadalafil in patients with head and neck squamous cell carcinoma.
Thu Jan 01 00:00:00 EST 2015
Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Yamada Y,Nadazdin O,Boskovic S,Lee S,Zorn E,Smith RN,Colvin RB,Madsen JC,Cosimi AB,Kawai T,Benichou G
14-4776 was used in Flow cytometry/Cell sorting to investigate the effect of repeated IL-2 injections on renal allograft tolerance in monkeys.
Tue Dec 01 00:00:00 EST 2015
Expression of TIM-3, Human β-defensin-2, and FOXP3 and Correlation with Disease Activity in Pediatric Crohn's Disease with Infliximab Therapy.
Gut and liver
Kim MJ,Lee WY,Choe YH
14-4776 was used in Flow cytometry/Cell sorting to suggests that both the adaptive and innate immune systems are closely linked to each other in CD pathogenesis.
Sat May 23 00:00:00 EDT 2015
Role of dendritic cells in the pathogenesis of Whipple's disease.
Infection and immunity
Schinnerling K,Geelhaar-Karsch A,Allers K,Friebel J,Conrad K,Loddenkemper C,Kühl AA,Erben U,Ignatius R,Moos V,Schneider T
14-4776 was used in Immunohistochemistry on paraffin embedded tissues to indicate that dysfunctional IL-12 production by DC provides suboptimal conditions for priming of T. whipplei-specific T cells.
Sun Feb 01 00:00:00 EST 2015
Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART.
Retrovirology
DaFonseca S,Niessl J,Pouvreau S,Wacleche VS,Gosselin A,Cleret-Buhot A,Bernard N,Tremblay C,Jenabian MA,Routy JP,Ancuta P
14477682 was used in flow cytometry to elucidate Th17 cell polarization, depletion, and restoration in response to HIV infection and antiretroviral therapy
Thu Apr 30 00:00:00 EDT 2015
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Nature medicine
Schubert D,Bode C,Kenefeck R,Hou TZ,Wing JB,Kennedy A,Bulashevska A,Petersen BS,Schäffer AA,Grüning BA,Unger S,Frede N,Baumann U,Witte T,Schmidt RE,Dueckers G,Niehues T,Seneviratne S,Kanariou M,Speckmann C,Ehl S,Rensing-Ehl A,Warnatz K,Rakhmanov M,Thimme R,Hasselblatt P,Emmerich F,Cathomen T,Backofen R,Fisch P,Seidl M,May A,Schmitt-Graeff A,Ikemizu S,Salzer U,Franke A,Sakaguchi S,Walker LSK,Sansom DM,Grimbacher B
14-4776 was used in Flow cytometry/Cell sorting to demonstrate the consequences for mice with mutations in CTLA4, an essential negative regulator of immune responses.
Mon Dec 01 00:00:00 EST 2014
HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.
The Journal of clinical investigation
Araya N,Sato T,Ando H,Tomaru U,Yoshida M,Coler-Reilly A,Yagishita N,Yamauchi J,Hasegawa A,Kannagi M,Hasegawa Y,Takahashi K,Kunitomo Y,Tanaka Y,Nakajima T,Nishioka K,Utsunomiya A,Jacobson S,Yamano Y
14-4776 was used in Flow cytometry/Cell sorting to study the cellular changes leading to the development of an inflammatory response to Human T-lymphotropic virus type 1 infection.
Fri Aug 01 00:00:00 EDT 2014
Memory regulatory T cells reside in human skin.
The Journal of clinical investigation
Sanchez Rodriguez R,Pauli ML,Neuhaus IM,Yu SS,Arron ST,Harris HW,Yang SH,Anthony BA,Sverdrup FM,Krow-Lucal E,MacKenzie TC,Johnson DS,Meyer EH,Löhr A,Hsu A,Koo J,Liao W,Gupta R,Debbaneh MG,Butler D,Huynh M,Levin EC,Leon A,Hoffman WY,McGrath MH,Alvarado MD,Ludwig CH,Truong HA,Maurano MM,Gratz IK,Abbas AK,Rosenblum MD
14-4776 was used in Immunofluorescence in immunohistochemistry on frozen tissues to characterise, both phenotypically and functionally, regulatory T cells in human skin.
Sat Mar 01 00:00:00 EST 2014
Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade.
Cancer immunology research
Cooper ZA,Juneja VR,Sage PT,Frederick DT,Piris A,Mitra D,Lo JA,Hodi FS,Freeman GJ,Bosenberg MW,McMahon M,Flaherty KT,Fisher DE,Sharpe AH,Wargo JA
14-4776 was used in Flow cytometry/Cell sorting to show anti-PD1 or anti-PDL1, with a BRAF inhibitor caused an enhanced response, significantly prolonging survival and slowing tumor growth.
Tue Jul 01 00:00:00 EDT 2014
Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Singh K,Stempora L,Harvey RD,Kirk AD,Larsen CP,Blazar BR,Kean LS
14-4776 was used in Flow cytometry/Cell sorting to suggest that rapamycin may be a necessary addition to Treg immunotherapy, and that tacrolimus may be deleterious to Treg integrity posttransfer.
Mon Dec 01 00:00:00 EST 2014
Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda.
Mucosal immunology
Prodger JL,Hirbod T,Kigozi G,Nalugoda F,Reynolds SJ,Galiwango R,Shahabi K,Serwadda D,Wawer MJ,Gray RH,Kaul R
14-4776 was used in Flow cytometry/Cell sorting to show that HESN foreskins had elevated α-defensins and HIV-neutralizing IgAs.
Thu May 01 00:00:00 EDT 2014
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.
Breast cancer research : BCR
García-Martínez E,Gil GL,Benito AC,González-Billalabeitia E,Conesa MA,García García T,García-Garre E,Vicente V,Ayala de la Peña F
14-4776 was used in Immunohistochemistry to investigate the association between the immune cell response to chemotherapy and breast cancer outcome.
Sat Nov 29 00:00:00 EST 2014
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.
Breast cancer research : BCR
García-Martínez E,Gil GL,Benito AC,González-Billalabeitia E,Conesa MA,García García T,García-Garre E,Vicente V,Ayala de la Peña F
14-4776 was used in Immunohistochemistry to investigate the association between the immune cell response to chemotherapy and breast cancer outcome.
Sat Nov 29 00:00:00 EST 2014
Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer.
Breast cancer research : BCR
García-Martínez E,Gil GL,Benito AC,González-Billalabeitia E,Conesa MA,García García T,García-Garre E,Vicente V,Ayala de la Peña F
14-4776 was used in Immunohistochemistry to investigate the association between the immune cell response to chemotherapy and breast cancer outcome.
Sat Nov 29 00:00:00 EST 2014
In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17.
The Journal of investigative dermatology
Keijsers RRMC,Hendriks AGM,van Erp PEJ,van Cranenbroek B,van de Kerkhof PCM,Koenen HJPM,Joosten I
14-4776 was used in Immunohistochemistry to study the involvement of IL-17-producing immune cells in psoriasis using a model of human skin inflammation.
Thu May 01 00:00:00 EDT 2014
Selective targeting of Toll-like receptors and OX40 inhibit regulatory T-cell function in follicular lymphoma.
International journal of cancer
Voo KS,Foglietta M,Percivalle E,Chu F,Nattamai D,Harline M,Lee ST,Bover L,Lin HY,Baladandayuthapani V,Delgado D,Luong A,Davis RE,Kwak LW,Liu YJ,Neelapu SS
14-4776 was used in Flow cytometry/Cell sorting to assess novel adjuvants that may enhance the efficacy of antitumour immunotherapeutic strategies by inhibiting Tregs.
Mon Dec 15 00:00:00 EST 2014
Isolation of human antigen-specific regulatory T cells with high suppressive function.
European journal of immunology
Noyan F,Lee YS,Zimmermann K,Hardtke-Wolenski M,Taubert R,Warnecke G,Knoefel AK,Schulde E,Olek S,Manns MP,Jaeckel E
14477682 was used in flow cytometry to show that latency-associated peptide and glycoprotein A repetitions predominant identify human antigen-specific T regulatory cells
Mon Sep 01 00:00:00 EDT 2014
Hemin controls T cell polarization in sickle cell alloimmunization.
Journal of immunology (Baltimore, Md. : 1950)
Zhong H,Bao W,Friedman D,Yazdanbakhsh K
14-4776 was used in Flow cytometry/Cell sorting to investigate whether monocyte control of T cell polarisation differs between alloimmunised and non-alloimmunised sickle cell disease patients.
Tue Jul 01 00:00:00 EDT 2014
CD20+ B cell depletion alters T cell homing.
Journal of immunology (Baltimore, Md. : 1950)
Kap YS,van Driel N,Laman JD,Tak PP,'t Hart BA
14-4776 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of CD20 depletion in the treatment of autoimmune inflammatory disorders, showing that CD20+ B cell depletion alters T cell homing.
Thu May 01 00:00:00 EDT 2014
Immune responses induced by T-cell vaccination in patients with rheumatoid arthritis.
Human vaccines & immunotherapeutics
Ivanova I,Seledtsova G,Mamaev S,Shishkov A,Seledtsov V
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Jun 22 00:00:00 EDT 2015
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
PloS one
Tang Y,Xu X,Guo S,Zhang C,Tang Y,Tian Y,Ni B,Lu B,Wang H
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Tue Jan 06 00:00:00 EST 2015
A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments.
BMC infectious diseases
Dos-Santos WL,Pagliari C,Santos LG,Almeida VA,e Silva TL,Coutinho Jde J,Souza T,Duarte MI,de Freitas LA,Costa CH
14-4776 was used in Immunohistochemistry on paraffin embedded tissues to study the distribution of leukocyte populations and of cytokine-producing cells in the spleen of a patient with visceral leishmaniasis resistant to clinical treatment.
Tue Sep 09 00:00:00 EDT 2014
The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface.
PloS one
Lee F,Luevano M,Veys P,Yong K,Madrigal A,Shaw BE,Saudemont A
14-4776 was used in Flow cytometry/Cell sorting to discover that there was no direct correlation between cell surface CD52 density and depleting effects of CAMPATH-1H.
Tue Nov 10 00:00:00 EST 2015
Immunopathogenesis of dengue hemorrhagic fever: contribution to the study of human liver lesions.
Journal of medical virology
Pagliari C,Quaresma JA,Fernandes ER,Stegun FW,Brasil RA,de Andrade HF,Barros V,Vasconcelos PF,Duarte MI
14-4776-82 was used in Immunohistochemistry-paraffin to characterize cytokines and some factors present in liver lesions and their possible role in the pathogenesis of hepatic injury.
Tue Jul 01 00:00:00 EDT 2014
Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells.
Blood
Peters JH,Koenen HJ,Fasse E,Tijssen HJ,Ijzermans JN,Groenen PJ,Schaap NP,Kwekkeboom J,Joosten I
14-4776 was used in Immunohistochemistry to suggest that human secondary lymphoid organs aid in the maintenance and regulation of regulatory T-cell function and homeostasis.
Thu Sep 26 00:00:00 EDT 2013
High PD-1 expression and suppressed cytokine signaling distinguish T cells infiltrating follicular lymphoma tumors from peripheral T cells.
Blood
Myklebust JH,Irish JM,Brody J,Czerwinski DK,Houot R,Kohrt HE,Timmerman J,Said J,Green MR,Delabie J,Kolstad A,Alizadeh AA,Levy R
14-4776 was used in Immunohistochemistry to identify that T cells infiltrating follicular lymphoma tumours are non-responsive to cytokines, in contrast to the corresponding autologous peripheral blood subset.
Thu Feb 21 00:00:00 EST 2013
Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.
The Journal of clinical investigation
Mueller C,Chulay JD,Trapnell BC,Humphries M,Carey B,Sandhaus RA,McElvaney NG,Messina L,Tang Q,Rouhani FN,Campbell-Thompson M,Fu AD,Yachnis A,Knop DR,Ye GJ,Brantly M,Calcedo R,Somanathan S,Richman LP,Vonderheide RH,Hulme MA,Brusko TM,Wilson JM,Flotte TR
14-4776 was used in Immunohistochemistry on frozen tissues to suggest that i.m. delivery of rAAV type 1-AAT induces a T regulatory response that allows ongoing transgene expression.
Sun Dec 01 00:00:00 EST 2013
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.
Science translational medicine
Matsuoka K,Koreth J,Kim HT,Bascug G,McDonough S,Kawano Y,Murase K,Cutler C,Ho VT,Alyea EP,Armand P,Blazar BR,Antin JH,Soiffer RJ,Ritz J
14-4776 was used in Flow cytometry/Cell sorting to define the mechanisms of action of IL-2 therapy for chronic graft-versus-host disease, showing that therapy restores regulatory T cell homeostasis.
Wed Apr 03 00:00:00 EDT 2013
Human regulatory T cells do not suppress the antitumor immunity in the bone marrow: a role for bone marrow stromal cells in neutralizing regulatory T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Guichelaar T,Emmelot ME,Rozemuller H,Martini B,Groen RW,Storm G,Lokhorst HM,Martens AC,Mutis T
14-4776 was used in Flow cytometry/Cell sorting to investigate Treg immunobiology and indicate the conditional benefits of future Treg-based terapies.
Fri Mar 15 00:00:00 EDT 2013
T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge.
The British journal of dermatology
Gambichler T,Terras S,Kampilafkos P,Kreuter A,Skrygan M
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunofluorescence
Sun Dec 01 00:00:00 EST 2013
Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T-cell exhaustion in reducing T-cell responses.
The Journal of investigative dermatology
Dowlatshahi M,Huang V,Gehad AE,Jiang Y,Calarese A,Teague JE,Dorosario AA,Cheng J,Nghiem P,Schanbacher CF,Thakuria M,Schmults CD,Wang LC,Clark RA
14-4776 was used in Flow cytometry/Cell sorting to identify tumor-specific T cells with suppressed activity in Merkel cell carcinoma tumors.
Mon Jul 01 00:00:00 EDT 2013
Human T cells upregulate CD69 after coculture with xenogeneic genetically-modified pig mesenchymal stromal cells.
Cellular immunology
Li J,Andreyev O,Chen M,Marco M,Iwase H,Long C,Ayares D,Shen Z,Cooper DK,Ezzelarab MB
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Jan 20 00:00:00 EST 2014
Short communication: HIV+ viremic slow progressors maintain low regulatory T cell numbers in rectal mucosa but exhibit high T cell activation.
AIDS research and human retroviruses
Shaw JM,Hunt PW,Critchfield JW,McConnell DH,Garcia JC,Pollard RB,Somsouk M,Deeks SG,Shacklett BL
14-4776 was used in Flow cytometry/Cell sorting to suggest that the HIV+ viremic slow progressor phenotype is associated with high immune activation but low numbers of mucosal regulatory T-cells.
Tue Jan 01 00:00:00 EST 2013
Reduced immunosuppressive properties of axitinib in comparison with other tyrosine kinase inhibitors.
The Journal of biological chemistry
Stehle F,Schulz K,Fahldieck C,Kalich J,Lichtenfels R,Riemann D,Seliger B
14-4776 was used in Flow cytometry/Cell sorting to reveal axitinib, rather than sorafenib, seems to be suitable for implementation in complex cancer treatment regimens.
Fri Jun 07 00:00:00 EDT 2013
Inhibition of CD4+CD25+ regulatory T cell function and conversion into Th1-like effectors by a Toll-like receptor-activated dendritic cell vaccine.
PloS one
Lee MK,Xu S,Fitzpatrick EH,Sharma A,Graves HL,Czerniecki BJ
14-4776 was used in Flow cytometry/Cell sorting to evaluate the mechanisms underlying the antigen-specific antitumour response promoted by vaccination with dendritic cells activated with LPS and IFN-γ.
Tue Jul 22 00:00:00 EDT 2014
Immunologic targeting of FOXP3 in inflammatory breast cancer cells.
PloS one
Nair S,Aldrich AJ,McDonnell E,Cheng Q,Aggarwal A,Patel P,Williams MM,Boczkowski D,Lyerly HK,Morse MA,Devi GR
14-4776 was used in Immunocytochemistry-immunoflourescence to identify FOXP3 as an effective tumour target in inflammatory breast cancer cells.
Tue Jul 09 00:00:00 EDT 2013
Suppression of tumour-specific CD4⁺ T cells by regulatory T cells is associated with progression of human colorectal cancer.
Gut
Betts G,Jones E,Junaid S,El-Shanawany T,Scurr M,Mizen P,Kumar M,Jones S,Rees B,Williams G,Gallimore A,Godkin A
14-4776 was used in Immunohistochemistry to demonstrate that CRC presence drives the activity of Tregs and the suppression of CD4+ T-cell responses to tumour-associated antigens.
Wed Aug 01 00:00:00 EDT 2012
Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients.
Science translational medicine
Clark RA,Watanabe R,Teague JE,Schlapbach C,Tawa MC,Adams N,Dorosario AA,Chaney KS,Cutler CS,Leboeuf NR,Carter JB,Fisher DC,Kupper TS
14-4776 was used in Flow cytometry/Cell sorting to investigate the efficacy of treatment of cutaneous T cell lymphoma using alemtuzumab.
Wed Jan 18 00:00:00 EST 2012
Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach.
British journal of cancer
Yoshii M,Tanaka H,Ohira M,Muguruma K,Iwauchi T,Lee T,Sakurai K,Kubo N,Yashiro M,Sawada T,Hirakawa K
14-4776 was used in Western Blotting to suggest that FoxP3 expression by tumour cells influences immune escape of gastric carcinoma, and the malignant potential of scirrhous gastric carcinoma.
Tue May 08 00:00:00 EDT 2012
A gynecologic oncology group phase II trial of two p53 peptide vaccine approaches: subcutaneous injection and intravenous pulsed dendritic cells in high recurrence risk ovarian cancer patients.
Cancer immunology, immunotherapy : CII
Rahma OE,Ashtar E,Czystowska M,Szajnik ME,Wieckowski E,Bernstein S,Herrin VE,Shams MA,Steinberg SM,Merino M,Gooding W,Visus C,Deleo AB,Wolf JK,Bell JG,Berzofsky JA,Whiteside TL,Khleif SN
14-4776 was used in Flow cytometry/Cell sorting to describe the immune response elicited by two vaccine approaches using the wild-type p53 vaccine.
Thu Mar 01 00:00:00 EST 2012
Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate.
Human reproduction (Oxford, England)
Braundmeier A,Jackson K,Hastings J,Koehler J,Nowak R,Fazleabas A
14-4776 was used in Immunohistochemistry to study how inducing endometriosis can alter the regulatory T cell population in the non-human primate.
Fri Jun 01 00:00:00 EDT 2012
Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate.
Human reproduction (Oxford, England)
Braundmeier A,Jackson K,Hastings J,Koehler J,Nowak R,Fazleabas A
14-4776 was used in Immunohistochemistry to study how inducing endometriosis can alter the regulatory T cell population in the non-human primate.
Fri Jun 01 00:00:00 EDT 2012
Impaired function of regulatory T cells in cord blood of children of allergic mothers.
Clinical and experimental immunology
Hrdý J,Kocourková I,Prokešová L
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2012
A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg.
Journal of immunology (Baltimore, Md. : 1950)
Schoenbrunn A,Frentsch M,Kohler S,Keye J,Dooms H,Moewes B,Dong J,Loddenkemper C,Sieper J,Wu P,Romagnani C,Matzmohr N,Thiel A
14-4776 was used in Immunohistochemistry to understand the effects of a converse 4-1BB and CD40 ligand expression pattern on T cells.
Sat Dec 15 00:00:00 EST 2012
The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Harris RC,Chianese-Bullock KA,Petroni GR,Schaefer JT,Brill LB,Molhoek KR,Deacon DH,Patterson JW,Slingluff CL
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Sun Jan 01 00:00:00 EST 2012
OMIP-006: phenotypic subset analysis of human T regulatory cells via polychromatic flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Murdoch DM,Staats JS,Weinhold KJ
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2012
PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20.
Cellular immunology
Nicholson IC,Mavrangelos C,Bird DR,Bresatz-Atkins S,Eastaff-Leung NG,Grose RH,Gundsambuu B,Hill D,Millard DJ,Sadlon TJ,To S,Zola H,Barry SC,Krumbiegel D
14477682 was used in flow cytometry to use PI16 to identify a subset of migratory functional memory T regulatory cells
Fri Jun 29 00:00:00 EDT 2012
Increased expression of regulatory T cells and down-regulatory molecules in lepromatous leprosy.
The American journal of tropical medicine and hygiene
Palermo ML,Pagliari C,Trindade MA,Yamashitafuji TM,Duarte AJ,Cacere CR,Benard G
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Immunohistochemistry
Tue May 01 00:00:00 EDT 2012
Novel serial positive enrichment technology enables clinical multiparameter cell sorting.
PloS one
Stemberger C,Dreher S,Tschulik C,Piossek C,Bet J,Yamamoto TN,Schiemann M,Neuenhahn M,Martin K,Schlapschy M,Skerra A,Schmidt T,Edinger M,Riddell SR,Germeroth L,Busch DH
14-4776 was used in Flow cytometry/Cell sorting to exhibit novel, low-affinity antibody-derived Fab-fragments for use in clinical cell preparations and research.
Mon Aug 27 00:00:00 EDT 2012
Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.
Oncoimmunology
Brusic A,Hainz U,Wadleigh M,Neuberg D,Su M,Canning CM,Deangelo DJ,Stone RM,Lee JS,Mulligan RC,Ritz J,Dranoff G,Sasada T,Wu CJ
14-4776 was used in Flow cytometry/Cell sorting to develop a method for detecting T-cell reactivity against K562 cell-derived antigens in patients.
Mon Oct 01 00:00:00 EDT 2012
High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma.
Blood
Clark RA,Shackelton JB,Watanabe R,Calarese A,Yamanaka K,Campbell JJ,Teague JE,Kuo HP,Hijnen D,Kupper TS
14-4776 was used in Flow cytometry/Cell sorting to demonstrate that the malignant T-cells in leukemic CTCL can be identified by a unique scatter profile.
Thu Feb 10 00:00:00 EST 2011
Significant mobilization of both conventional and regulatory T cells with AMD3100.
Blood
Kean LS,Sen S,Onabajo O,Singh K,Robertson J,Stempora L,Bonifacino AC,Metzger ME,Promislow DE,Mattapallil JJ,Donahue RE
14-4776 was used in Flow cytometry/Cell sorting to indicate that AMD3100 may mobilize a GVHD-protective T-cell repertoire.
Thu Dec 15 00:00:00 EST 2011
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.
Journal of virology
Vinton C,Klatt NR,Harris LD,Briant JA,Sanders-Beer BE,Herbert R,Woodward R,Silvestri G,Pandrea I,Apetrei C,Hirsch VM,Brenchley JM
14-4776 was used in Flow cytometry/Cell sorting to demonstrate that coevolution with SIV has, in several cases, involved downregulation of receptors for the virus by otherwise-susceptible host target cells.
Thu Sep 01 00:00:00 EDT 2011
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.
Journal of virology
Vinton C,Klatt NR,Harris LD,Briant JA,Sanders-Beer BE,Herbert R,Woodward R,Silvestri G,Pandrea I,Apetrei C,Hirsch VM,Brenchley JM
14-4776 was used in Flow cytometry/Cell sorting to demonstrate that coevolution with SIV has, in several cases, involved downregulation of receptors for the virus by otherwise-susceptible host target cells.
Thu Sep 01 00:00:00 EDT 2011
Decreased AIRE expression and global thymic hypofunction in Down syndrome.
Journal of immunology (Baltimore, Md. : 1950)
Lima FA,Moreira-Filho CA,Ramos PL,Brentani H,Lima Lde A,Arrais M,Bento-de-Souza LC,Bento-de-Souza L,Duarte MI,Coutinho A,Carneiro-Sampaio M
14-4776 was used in Immunohistochemistry to demonstrate that Down syndrome should be considered as a non-monogenic primary immunodeficiency.
Thu Sep 15 00:00:00 EDT 2011
HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance.
Transplantation
Castellaneta A,Mazariegos GV,Nayyar N,Zeevi A,Thomson AW
14-4776 was used in Flow cytometry/Cell sorting to investigate the correlation between HLA-G level on monocytoid dendritic cells and regulatory T cell Foxp3 expression in liver transplant tolerance.
Fri May 27 00:00:00 EDT 2011
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Investigative ophthalmology & visual science
Dasgupta G,Chentoufi AA,You S,Falatoonzadeh P,Urbano LA,Akhtarmalik A,Nguyen K,Ablabutyan L,Nesburn AB,BenMohamed L
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2011
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses.
Investigative ophthalmology & visual science
Dasgupta G,Chentoufi AA,You S,Falatoonzadeh P,Urbano LA,Akhtarmalik A,Nguyen K,Ablabutyan L,Nesburn AB,BenMohamed L
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Tue May 17 00:00:00 EDT 2011
Clinical implications and characteristics of factor forkhead box protein 3 in gastric cancer.
Experimental and therapeutic medicine
Jiang C,Wang W,Yan W,Zhang Y,Yang J,Zhang S,Zhang C,Zhang W,Han W,Wang J,Zhang YQ
14-4776 was used in Immunohistochemistry to evaluate the clinical and biological characteristics of FOXP3 in human gastric cancer.
Fri Jul 01 00:00:00 EDT 2011
Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells.
Journal of experimental & clinical cancer research : CR
Sun J,Yu J,Li H,Yang L,Wei F,Yu W,Liu J,Ren X
14-4776 was used in Western blot to confirm the role of indoleamine 2, 3-dioxygenase in the maturation and development of Tregs in breast cancer patients.
Wed Sep 14 00:00:00 EDT 2011
Rapid temporal control of Foxp3 protein degradation by sirtuin-1.
PloS one
van Loosdregt J,Brunen D,Fleskens V,Pals CE,Lam EW,Coffer PJ
14-4776 was used in Flow cytometry/Cell sorting to support a central role for SIRT1 in the regulation of Foxp3 protein levels and thereby in regulation of Treg suppressive capacity.
Wed Apr 20 00:00:00 EDT 2011
T cell subpopulations in lymph nodes may not be predictive of patient outcome in colorectal cancer.
Journal of experimental & clinical cancer research : CR
Kemp RA,Black MA,McCall J,Yoon HS,Phillips V,Anjomshoaa A,Reeve AE
14-4776 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to indicate that frequency of specific T cell subsets in lymph nodes may not be a useful tool for predicting patient outcome.
Wed Aug 24 00:00:00 EDT 2011
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
Blood
van Loosdregt J,Vercoulen Y,Guichelaar T,Gent YY,Beekman JM,van Beekum O,Brenkman AB,Hijnen DJ,Mutis T,Kalkhoven E,Prakken BJ,Coffer PJ
14-4776 was used in Flow cytometry/Cell sorting to demonstrate that modulation of the acetylation state of Foxp3 regulates Treg numbers and functionality.
Thu Feb 04 00:00:00 EST 2010
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
Blood
van Loosdregt J,Vercoulen Y,Guichelaar T,Gent YY,Beekman JM,van Beekum O,Brenkman AB,Hijnen DJ,Mutis T,Kalkhoven E,Prakken BJ,Coffer PJ
14-4776 was used in Flow cytometry/Cell sorting to demonstrate that modulation of the acetylation state of Foxp3 regulates Treg numbers and functionality.
Thu Feb 04 00:00:00 EST 2010
CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function.
The Journal of experimental medicine
Rivino L,Gruarin P,Häringer B,Steinfelder S,Lozza L,Steckel B,Weick A,Sugliano E,Jarrossay D,Kühl AA,Loddenkemper C,Abrignani S,Sallusto F,Lanzavecchia A,Geginat J
14-4776 was used in Immunohistochemistry to propose that memory T cells, which can participate in secondary immune responses, contribute to the maintenance of tolerance under steady-state conditions.
Mon Mar 15 00:00:00 EDT 2010
An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Larsen CP,Page A,Linzie KH,Russell M,Deane T,Stempora L,Strobert E,Penedo MC,Ward T,Wiseman R,O'Connor D,Miller W,Sen S,Singh K,Kean LS
14-4776 was used in Flow cytometry/Cell sorting to study mixed hematopoietic chimerism and immune tolerance in a novel MHC-defined rhesus macaque model.
Mon Nov 01 00:00:00 EDT 2010
CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection.
The Journal of infectious diseases
Green AM,Mattila JT,Bigbee CL,Bongers KS,Lin PL,Flynn JL
14-4776 was used in Flow cytometry/Cell sorting to investigate CD4 regulatory T cell responses to Mycobacterium tuberculosis infection in cynomolgus macaques.
Sun Aug 15 00:00:00 EDT 2010
Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway.
Molecular cancer therapeutics
Wei J,Barr J,Kong LY,Wang Y,Wu A,Sharma AK,Gumin J,Henry V,Colman H,Priebe W,Sawaya R,Lang FF,Heimberger AB
14-4776 was used in Flow cytometry/Cell sorting to investigate the mechanism by which glioblastoma cancer-initiating cells inhibit T cell proliferation and effector responses.
Fri Jan 01 00:00:00 EST 2010
CD30 discriminates heat shock protein 60-induced FOXP3+ CD4+ T cells with a regulatory phenotype.
Journal of immunology (Baltimore, Md. : 1950)
de Kleer I,Vercoulen Y,Klein M,Meerding J,Albani S,van der Zee R,Sawitzki B,Hamann A,Kuis W,Prakken B
14-4776-82 was used in Flow cytometry to study the ability of CD38 to distinguish between nonsuppressive and suppressive FoxP3(+) regulatory T cells.
Sun Aug 15 00:00:00 EDT 2010
CD40 signalling induces IL-10-producing, tolerogenic dendritic cells.
Experimental dermatology
Tuettenberg A,Fondel S,Steinbrink K,Enk AH,Jonuleit H
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2010
Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis.
PloS one
Smolders J,Peelen E,Thewissen M,Cohen Tervaert JW,Menheere P,Hupperts R,Damoiseaux J
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Dec 13 00:00:00 EST 2010
Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis.
Journal of translational medicine
Schaefer JT,Patterson JW,Deacon DH,Smolkin ME,Petroni GR,Jackson EM,Slingluff CL
14-4776 was used in Immunohistochemistry to demonstrate that multipeptide/incomplete Freund's adjuvant vaccine may induce a Th2-dominant microenvironment, which is reversed with repeat vaccination.
Fri Aug 20 00:00:00 EDT 2010
Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies.
Journal of translational medicine
Bonanno G,Procoli A,Mariotti A,Corallo M,Perillo A,Danese S,De Cristofaro R,Scambia G,Rutella S
14-4776 was used in Flow cytometry/Cell sorting to show that Pegfilgrastim induced significant changes in immune cell number and function.
Tue Nov 09 00:00:00 EST 2010
FOXP3 expression and overall survival in breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Merlo A,Casalini P,Carcangiu ML,Malventano C,Triulzi T,Mènard S,Tagliabue E,Balsari A
14-4776 was used in Immunohistochemistry to characterise FOXP3 expression patterns in primary breast carcinoma specimens from patients with breast cancer and assess for prognostic relevance.
Fri Apr 10 00:00:00 EDT 2009
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells.
Blood
Kleinewietfeld M,Starke M,Di Mitri D,Borsellino G,Battistini L,Rötzschke O,Falk K
14-4776 was used in Flow cytometry/Cell sorting to investigate more effective markers for the isolation of Tregs for their use in adoptive transfer.
Thu Jan 22 00:00:00 EST 2009
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.
Blood
Houot R,Goldstein MJ,Kohrt HE,Myklebust JH,Alizadeh AA,Lin JT,Irish JM,Torchia JA,Kolstad A,Chen L,Levy R
14-4776 was used in Flow cytometry/Cell sorting to demonstrate the antitumor effect of anti-CD137 therapy, mediated by natural killer (NK) and CD8 T cells inducing long-lasting immunity.
Thu Oct 15 00:00:00 EDT 2009
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Mandapathil M,Szczepanski MJ,Szajnik M,Ren J,Lenzner DE,Jackson EK,Gorelik E,Lang S,Johnson JT,Whiteside TL
14-4776 was used in Flow cytometry/Cell sorting to evaluate the involvement of the adenosinergic pathway in Treg-mediated suppression in head and neck squamous cell carcinoma (HNSCC) patients.
Thu Oct 15 00:00:00 EDT 2009
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.
Cancer research
Wieczorek G,Asemissen A,Model F,Turbachova I,Floess S,Liebenberg V,Baron U,Stauch D,Kotsch K,Pratschke J,Hamann A,Loddenkemper C,Stein H,Volk HD,Hoffmüller U,Grützkau A,Mustea A,Huehn J,Scheibenbogen C,Olek S
14-4776 was used in Immunohistochemistry to demonstrate a novel method for monitoring Treg cells in human peripheral blood and solid tissues based on Treg-specific DNA demethylation.
Thu Jan 15 00:00:00 EST 2009
Foxp3 regulates megakaryopoiesis and platelet function.
Arteriosclerosis, thrombosis, and vascular biology
Bernard JJ,Seweryniak KE,Koniski AD,Spinelli SL,Blumberg N,Francis CW,Taubman MB,Palis J,Phipps RP
14-4776 was used in Flow cytometry/Cell sorting to study how Foxp3 is needed for proper megakaryopoiesus and plays a role in regulating platelet function.
Sun Nov 01 00:00:00 EDT 2009
Human peripheral gammadelta T cells possess regulatory potential.
Immunology
Kühl AA,Pawlowski NN,Grollich K,Blessenohl M,Westermann J,Zeitz M,Loddenkemper C,Hoffmann JC
14-4776 was used in Immunocytochemistry-immunoflourescence to study the in vitro regulatory potential of peripheral gammadelta T cells.
Tue Dec 01 00:00:00 EST 2009
Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Nagata S,Ise T,Pastan I
Published figure using FOXP3 monoclonal antibody (Product # 14-4776-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2009
Cutting Edge: Responder T cells regulate human DR+ effector regulatory T cell activity via granzyme B.
Journal of immunology (Baltimore, Md. : 1950)
Ashley CW,Baecher-Allan C
14-4776 was used in Flow cytometry/Cell sorting to show that responder cells actively kill effector Tregs by producing Granzyme B in response to strong TCR stimulation.
Thu Oct 15 00:00:00 EDT 2009
Selective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand.
Journal of immunology (Baltimore, Md. : 1950)
Bohana-Kashtan O,Morisot S,Hildreth R,Brayton C,Levitsky HI,Civin CI
14-4776 was used in Flow cytometry/Cell sorting to investigate T cell ex vivo treatment with soluble Fas ligand as a mechanism to selectively reduce graft-versus-host-disease mediating cells.
Wed Jul 01 00:00:00 EDT 2009
HIV-1 binding to CD4 on CD4+CD25+ regulatory T cells enhances their suppressive function and induces them to home to, and accumulate in, peripheral and mucosal lymphoid tissues: an additional mechanism of immunosuppression.
International immunology
Ji J,Cloyd MW
14-4776 was used in Flow cytometry/Cell sorting to examine the effect that HIV has upon binding to CD4+CD25+ Treg cells.
Sun Mar 01 00:00:00 EST 2009
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Law JP,Hirschkorn DF,Owen RE,Biswas HH,Norris PJ,Lanteri MC
14-4776 was used in Flow cytometry/Cell sorting to develop a multiparameter flow cytometric panel with Foxp3 for optimal identification of Tregs.
Tue Dec 01 00:00:00 EST 2009
Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder.
PloS one
Yamano Y,Araya N,Sato T,Utsunomiya A,Azakami K,Hasegawa D,Izumi T,Fujita H,Aratani S,Yagishita N,Fujii R,Nishioka K,Jacobson S,Nakajima T
14-4776 was used in Flow cytometry/Cell sorting to distinguish the HTLV-1 infected T cell subset contributing to neuroinflammation in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Wed Aug 05 00:00:00 EDT 2009
Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking.
The European respiratory journal
Barceló B,Pons J,Ferrer JM,Sauleda J,Fuster A,Agustí AG
14-4776 was used in Flow cytometry/Cell sorting to indicate a final maturation-activation state of CD8+ T-lymphocytes in chronic obstructive pulmonary disease.
Sat Mar 01 00:00:00 EST 2008
FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions.
Blood
Ahmadzadeh M,Felipe-Silva A,Heemskerk B,Powell DJ,Wunderlich JR,Merino MJ,Rosenberg SA
14-4776 was used in Immunohistochemistry on paraffin embedded tissues to investigate the functional characteristics of Tregs in human tumours.
Mon Dec 15 00:00:00 EST 2008
The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells.
Cancer research
Ebert LM,Tan BS,Browning J,Svobodova S,Russell SE,Kirkpatrick N,Gedye C,Moss D,Ng SP,MacGregor D,Davis ID,Cebon J,Chen W
14-4776 was used in Western Blotting to show that FoxP3 is not only expressed by regulatory T-cells but also by a wide variety of tumor cell lines.
Tue Apr 15 00:00:00 EDT 2008
High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability.
British journal of cancer
Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor M
14-4776 was used in Immunohistochemistry to study the role of forkhead box P3 positive cells in the regulation of the immune response directed against high-level microsatellite instability colorectal cancers at the primary tumour site.
Tue Dec 02 00:00:00 EST 2008
Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes.
Clinical and experimental immunology
Velásquez-Lopera MM,Correa LA,García LF
14-4776-82 was used in Immunohistochemistry to shows the frequency, phenotype and location of DCs and regulatory T cells in deceased organ donors' spleens.
Wed Oct 01 00:00:00 EDT 2008
Fusions of dendritic cells with breast carcinoma stimulate the expansion of regulatory T cells while concomitant exposure to IL-12, CpG oligodeoxynucleotides, and anti-CD3/CD28 promotes the expansion of activated tumor reactive cells.
Journal of immunology (Baltimore, Md. : 1950)
Vasir B,Wu Z,Crawford K,Rosenblatt J,Zarwan C,Bissonnette A,Kufe D,Avigan D
14-4776 was used in Flow cytometry/Cell sorting to examine the biological characteristics of DC/breast carcinoma fusions used as a cancer vaccine, and the nature of the vaccine-mediated T cell response.
Tue Jul 01 00:00:00 EDT 2008
Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Kasprzycka M,Zhang Q,Witkiewicz A,Marzec M,Potoczek M,Liu X,Wang HY,Milone M,Basu S,Mauger J,Choi JK,Abrams JT,Hou JS,Rook AH,Vonderheid E,Woetmann A,Odum N,Wasik MA
14-4776 was used in Western Blotting to investigate the effect of gamma c-signalling cytokines on CD4+ T cells.
Fri Aug 15 00:00:00 EDT 2008
Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells.
International immunology
Nagar M,Vernitsky H,Cohen Y,Dominissini D,Berkun Y,Rechavi G,Amariglio N,Goldstein I
14-4776 was used in Flow cytometry/Cell sorting to investigate the mode of de novo activation-dependent expression of FOXP3 in conventional human CD4+ T cells.
Fri Aug 01 00:00:00 EDT 2008
Foxp3 expression in human cancer cells.
Journal of translational medicine
Karanikas V,Speletas M,Zamanakou M,Kalala F,Loules G,Kerenidi T,Barda AK,Gourgoulianis KI,Germenis AE
14-4776 was used in Flow cytometry/Cell sorting to show evidence that Foxp3 expression can characterizes tumor cells of various tissue origins.
Tue Apr 22 00:00:00 EDT 2008
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation
Humblet-Baron S,Sather B,Anover S,Becker-Herman S,Kasprowicz DJ,Khim S,Nguyen T,Hudkins-Loya K,Alpers CE,Ziegler SF,Ochs H,Torgerson T,Campbell DJ,Rawlings DJ
14-4776 was used in Flow cytometry/Cell sorting to investigate whether alterations in Treg function might explain Wiskott-Aldrich syndrome pathology, showing that WASp is required for Treg homeostasis.
Thu Feb 01 00:00:00 EST 2007
Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection.
The Journal of experimental medicine
Lühn K,Simmons CP,Moran E,Dung NT,Chau TN,Quyen NT,Thao le TT,Van Ngoc T,Dung NM,Wills B,Farrar J,McMichael AJ,Dong T,Rowland-Jones S
14-4776 was used in Flow cytometry/Cell sorting to investigate whether a defective population of Tregs can contribute to immunopathology in severe dengue disease.
Mon May 14 00:00:00 EDT 2007
FOXP3 regulates TLR10 expression in human T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Bell MP,Svingen PA,Rahman MK,Xiong Y,Faubion WA
Wed Aug 01 00:00:00 EDT 2007
Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Powell DJ,Felipe-Silva A,Merino MJ,Ahmadzadeh M,Allen T,Levy C,White DE,Mavroukakis S,Kreitman RJ,Rosenberg SA,Pastan I
14-4776 was used in Flow cytometry/Cell sorting to suggest that more comprehensive Treg cell elimination may be required to bolster antitumor responses in patients with metastatic melanoma.
Mon Oct 01 00:00:00 EDT 2007
Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Powell DJ,Felipe-Silva A,Merino MJ,Ahmadzadeh M,Allen T,Levy C,White DE,Mavroukakis S,Kreitman RJ,Rosenberg SA,Pastan I
14-4776 was used in Flow cytometry/Cell sorting to suggest that more comprehensive Treg cell elimination may be required to bolster antitumor responses in patients with metastatic melanoma.
Mon Oct 01 00:00:00 EDT 2007
Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B.
International immunology
Yang G,Liu A,Xie Q,Guo TB,Wan B,Zhou B,Zhang JZ
14-4776 was used in Immunohistochemistry to examine the role of CD4+CD25+Foxp3+ regulatory T cells in disease activity and viral clearance in hepatitis B infection.
Thu Feb 01 00:00:00 EST 2007
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.
Blood
Ahmadzadeh M,Rosenberg SA
Wed Mar 15 00:00:00 EST 2006
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Blood
Epple HJ,Loddenkemper C,Kunkel D,Tröger H,Maul J,Moos V,Berg E,Ullrich R,Schulzke JD,Stein H,Duchmann R,Zeitz M,Schneider T
Wed Nov 01 00:00:00 EST 2006
Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.
Cancer research
Fecci PE,Mitchell DA,Whitesides JF,Xie W,Friedman AH,Archer GE,Herndon JE,Bigner DD,Dranoff G,Sampson JH
14-4776 was used in Flow cytometry/Cell sorting to demonstrate the differential numbers and proportions of CD4(+) and Tregs in patients with malignant glioma.
Wed Mar 15 00:00:00 EST 2006
In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer.
Journal of translational medicine
Loddenkemper C,Schernus M,Noutsias M,Stein H,Thiel E,Nagorsen D
14-4776 was used in Immunohistochemistry to analyse Treg infiltration in situ in colorectal cancer patients and investigate its relationship with disease stage, systemic T cell response, and survival.
Wed Dec 13 00:00:00 EST 2006
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Hillsamer P,Banham AH,Kim CH
Sat Oct 01 00:00:00 EDT 2005
