Product References
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
XIAP promotes the expansion and limits the contraction of CD8 T cell response through cell extrinsic and intrinsic mechanisms respectively.
PLoS pathogens
Thakker P,Ariana A,Hajjar S,Cai D,Rijal D,Sad S
12-0452-82 was used in Flow cytometry/Cell sorting to reveal the temporal impact of XIAP in promoting the fitness of activated CD8 T cells through cell extrinsic and intrinsic mechanisms and provide a mechanistic explanation of the phenotype observed in XLP-2 patients.
Thu Jun 01 00:00:00 EDT 2023
IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma.
Haematologica
Pisano MD,Sun F,Cheng Y,Parashar D,Zhou V,Jing X,Sompallae R,Abrudan J,Zimmermann MT,Mathison A,Janz S,Pufall MA
12-0452-82 was used in Flow Cytometry to indicate that the IL6Myc model is useful for studying development of aggressive MM and for developing new treatments against such forms of the disease.
Fri Dec 01 00:00:00 EST 2023
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.
Nature immunology
Subramanian S,Busch CJ,Molawi K,Geirsdottir L,Maurizio J,Vargas Aguilar S,Belahbib H,Gimenez G,Yuda RAA,Burkon M,Favret J,Gholamhosseinian Najjar S,de Laval B,Kandalla PK,Sarrazin S,Alexopoulou L,Sieweke MH
12-0452-82 was used in Flow Cytometry to study long-term mouse ex vivo alveolar macrophage gene expression and culture adaptations.
Tue Mar 01 00:00:00 EST 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
12-0452-82 was used in Flow Cytometry to show that sub-chronic stress increased sphingosine-1-phosphate (S1P) in the mouse colon, possibly due to a decrease in its degradation enzymes and sphingosine kinase 2 (Sphk2).
Tue Mar 08 00:00:00 EST 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
12-0452-82 was used in Flow Cytometry to show that sub-chronic stress increased sphingosine-1-phosphate (S1P) in the mouse colon, possibly due to a decrease in its degradation enzymes and sphingosine kinase 2 (Sphk2).
Tue Mar 08 00:00:00 EST 2022
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
JCI insight
Zhong L,Yao L,Holdreith N,Yu W,Gui T,Miao Z,Elkaim Y,Li M,Gong Y,Pacifici M,Maity A,Busch TM,Joeng KS,Cengel K,Seale P,Tong W,Qin L
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
12-0452-82 was used in Flow cytometry/Cell sorting to provide mechanistic insights on FGF-2 signaling in the modulation of VEGF pathway activation in the NPC microenvironment and propose an effective NPC-targeted therapy by using a clinically available drug.
Fri Aug 19 00:00:00 EDT 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
12-0452-82 was used in Flow cytometry/Cell sorting to provide mechanistic insights on FGF-2 signaling in the modulation of VEGF pathway activation in the NPC microenvironment and propose an effective NPC-targeted therapy by using a clinically available drug.
Fri Aug 19 00:00:00 EDT 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.
The Journal of biological chemistry
Yan Q,Gao H,Yao Q,Ling K,Xiao G
12-0452-82 was used in Flow Cytometry to determine whether phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) plays a role in skeletal development and homeostasis and what the underlying mechanisms are.
Tue Mar 01 00:00:00 EST 2022
Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.
Mucosal immunology
Wittner J,Schulz SR,Steinmetz TD,Berges J,Hauke M,Channell WM,Cunningham AF,Hauser AE,Hutloff A,Mielenz D,Jäck HM,Schuh W
12-0452-82 was used in Flow cytometry/Cell sorting to conclude that KLF2 not only orchestrates the localization of IgA plasma cells by fine-tuning chemokine receptors and adhesion molecules but also controls IgA responses to Salmonella flagellin.
Fri Apr 01 00:00:00 EDT 2022
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Nov 10 00:00:00 EST 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Nov 10 00:00:00 EST 2021
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia.
Infection and immunity
Sen-Kilic E,Blackwood CB,Huckaby AB,Horspool AM,Weaver KL,Malkowski AC,Witt WT,Bevere JR,Damron FH,Barbier M
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Jan 19 00:00:00 EST 2021
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem cell research
Sudo K,Yamazaki S,Wilkinson AC,Nakauchi H,Nakamura Y
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
eLife
Hill DL,Whyte CE,Innocentin S,Lee JL,Dooley J,Wang J,James EA,Lee JC,Kwok WW,Zand MS,Liston A,Carr EJ,Linterman MA
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Nov 02 00:00:00 EDT 2021
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
JCI insight
Wilson CS,Stocks BT,Hoopes EM,Rhoads JP,McNew KL,Major AS,Moore DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Oct 08 00:00:00 EDT 2021
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Nature communications
Shang M,Yang H,Yang R,Chen T,Fu Y,Li Y,Fang X,Zhang K,Zhang J,Li H,Cao X,Gu J,Xiao J,Zhang Q,Liu X,Yu Q,Wang T
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.
The Journal of biological chemistry
Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity.
Cell reports
Wang Y,Song M,Liu M,Zhang G,Zhang X,Li MO,Ma X,Zhang JJ,Huang XY
12-0452-82 was used in Flow Cytometry to investigate the effects of fascin blockade in anti-tumor immune responses in syngeneic mouse models of various cancers.
Tue Apr 06 00:00:00 EDT 2021
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases.
iScience
Xu Y,Liu E,Xie X,Wang J,Zheng H,Ju Y,Chen L,Li C,Zhou X,Li Z,Li X,Meng S
12-0452-82 was used in Flow cytometry/Cell sorting to show that gp96 immunization restricted antibody-induced and Th-induced autoimmune diseases by integrating Treg expansion and activation, indicating its potential clinical usefulness against autoimmune diseases.
Fri Dec 17 00:00:00 EST 2021
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Immunity
Lederer K,Castaño D,Gómez Atria D,Oguin TH,Wang S,Manzoni TB,Muramatsu H,Hogan MJ,Amanat F,Cherubin P,Lundgreen KA,Tam YK,Fan SHY,Eisenlohr LC,Maillard I,Weissman D,Bates P,Krammer F,Sempowski GD,Pardi N,Locci M
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
12-0452-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency.
Cell stem cell
Liang R,Arif T,Kalmykova S,Kasianov A,Lin M,Menon V,Qiu J,Bernitz JM,Moore K,Lin F,Benson DL,Tzavaras N,Mahajan M,Papatsenko D,Ghaffari S
12-0452-82 was used in Flow Cytometry to investigate the overall metabolic properties of hematopoietic stem cells.
Thu Mar 05 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.
Annals of surgery
Moore AL,desJardins-Park HE,Duoto BA,Mascharak S,Murphy MP,Irizarry DM,Foster DS,Jones RE,Barnes LA,Marshall CD,Ransom RC,Wernig G,Longaker MT
12-0452 was used in Flow cytometry/Cell sorting to investigate the effects of local doxycycline administration on skin scarring.
Wed Jul 01 00:00:00 EDT 2020
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Proceedings of the National Academy of Sciences of the United States of America
Tian M,McGovern K,Cheng HL,Waddicor P,Rieble L,Dao M,Chen Y,Kimble MT,Cantor E,Manfredonia N,Judson R,Chapdelaine-Williams A,Cain DW,Haynes BF,Alt FW
12-0452 was used in Flow cytometry/Cell sorting to develop a new approach to test a vaccine which circumvents B cell developmental blocks.
Tue Apr 07 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Frontiers in immunology
Larson SR,Bortell N,Illies A,Crisler WJ,Matsuda JL,Lenz LL
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Jun 14 00:00:00 EDT 2021
BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.
eLife
Li J,Zhang L,Zheng Y,Shao R,Liang Q,Yu W,Wang H,Zou W,Wang D,Xiang J,Lin A
12-0452-82 was used in Flow Cytometry to put forward a model in which inactivation of BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of arthritis, suggesting that BAD may be a potential therapeutic target for RA.
Thu Dec 03 00:00:00 EST 2020
Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain.
eLife
Cabañero D,Ramírez-López A,Drews E,Schmöle A,Otte DM,Wawrzczak-Bargiela A,Huerga Encabo H,Kummer S,Ferrer-Montiel A,Przewlocki R,Zimmer A,Maldonado R
12-0452 was used in Flow cytometry/Cell sorting to study the role of the cannabinoid 2 receptor in regulating spontaneous neuropathic pain through allowing self administration of a CB2 agonist in wildtype and CB2 knockout mice models.
Mon Jul 20 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
12-0452 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.
Cell death & disease
Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M
12-0452 was used in Flow cytometry/Cell sorting to show enhancer of zeste homolog 2 can mediate anti-inflammatory effects by inhibiting RUNX1 in dendritic cells.
Tue Dec 01 00:00:00 EST 2020
Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.
Frontiers in pharmacology
Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y
12-0452-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.
Tue Feb 16 00:00:00 EST 2021
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
12-0452-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 EDT 2021
mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
Science advances
Thumkeo D,Katsura Y,Nishimura Y,Kanchanawong P,Tohyama K,Ishizaki T,Kitajima S,Takahashi C,Hirata T,Watanabe N,Krummel MF,Narumiya S
12-0452 was used in Flow cytometry/Cell sorting to show that spatiotemporal control of Zap70-dependent LAT phosphorylation at the immune synapse is achieved by mDia1/3 regulation of filamentous actin.
Wed Jan 01 00:00:00 EST 2020
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y
12-0452-82 was used in Flow cytometry/Cell sorting to unravel a promising biophotonic strategy for precision treatment of cancer.
Tue Dec 01 00:00:00 EST 2020
Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity.
Cell
Cohen JA,Edwards TN,Liu AW,Hirai T,Jones MR,Wu J,Li Y,Zhang S,Ho J,Davis BM,Albers KM,Kaplan DH
12-0452-82 was used in Flow Cytometry to demonstrate the existence of functional anticipatory innate immunity at sites adjacent to infection that depends on antidromic neuron activation.
Thu Aug 08 00:00:00 EDT 2019
A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation.
Immunity
Roy K,Mitchell S,Liu Y,Ohta S,Lin YS,Metzig MO,Nutt SL,Hoffmann A
12-0452-82 was used in Flow Cytometry to provide a mechanistic explanation of how dysregulation of this bi-stable circuit might result in pathologic B cell population phenotypes and thus offer new avenues for diagnostic stratification and treatment.
Tue Mar 19 00:00:00 EDT 2019
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Cell metabolism
Hao X,Gu H,Chen C,Huang D,Zhao Y,Xie L,Zou Y,Shu HS,Zhang Y,He X,Lai X,Zhang X,Zhou BO,Zhang CC,Chen GQ,Yu Z,Yang Y,Zheng J
12-0452 was used in Flow cytometry/Cell sorting to provide a unique angle for the study of metabolisms in stem cells, and may lead to development of novel strategies for cancer treatment.
Tue Apr 02 00:00:00 EDT 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
12-0452 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Cell stem cell
Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK
12-0452 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.
Thu Apr 04 00:00:00 EDT 2019
p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells.
Stem cells (Dayton, Ohio)
Li X,Wu L,Zopp M,Kopelov S,Du W
12-0452-82 was used in Flow Cytometry to suggest that p53-TIGAR metabolic axis-mediated glycolytic suppression may play a compensatory role in attenuating DNA damage and proliferative exhaustion in FA HSCs.
Mon Jul 01 00:00:00 EDT 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue May 14 00:00:00 EDT 2019
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.
Cell reports
Adane B,Ye H,Khan N,Pei S,Minhajuddin M,Stevens BM,Jones CL,D'Alessandro A,Reisz JA,Zaberezhnyy V,Gasparetto M,Ho TC,Kelly KK,Myers JR,Ashton JM,Siegenthaler J,Kume T,Campbell EL,Pollyea DA,Becker MW,Jordan CT
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Apr 02 00:00:00 EDT 2019
Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H
12-0452-82 was used in Flow Cytometry to reveal a critical role of Lys376-mediated ubiquitination of RIPK1 in suppressing RIPK1 kinase activity-dependent lethal pathways during embryogenesis and RIPK3-dependent inflammation postnatally.
Fri Sep 13 00:00:00 EDT 2019
Incorporating B cell activating factor (BAFF) into the membrane of rabies virus (RABV) particles improves the speed and magnitude of vaccine-induced antibody responses.
PLoS neglected tropical diseases
Plummer JR,McGettigan JP
12-0452-82 was used in Flow Cytometry to stand as a potential foundation for exploring other virus membrane-anchored molecular adjuvants to make safer, more effective inactivated RABV-based vaccines.
Fri Nov 01 00:00:00 EDT 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
12-0452 was used in Flow cytometry/Cell sorting to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
Cell research
Chen J,Cai Z,Bai M,Yu X,Zhang C,Cao C,Hu X,Wang L,Su R,Wang D,Wang L,Yao Y,Ye R,Hou B,Yu Y,Yu S,Li J,Xue Y
12-0452 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to identify an RNA-binding protein that is both required and sufficient to define activation-induced cytidine deaminase-binding sites genome-wide in activated B cells.
Mon Oct 01 00:00:00 EDT 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
12-0452 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
The Journal of experimental medicine
Nagase R,Inoue D,Pastore A,Fujino T,Hou HA,Yamasaki N,Goyama S,Saika M,Kanai A,Sera Y,Horikawa S,Ota Y,Asada S,Hayashi Y,Kawabata KC,Takeda R,Tien HF,Honda H,Abdel-Wahab O,Kitamura T
12-0452 was used in Flow cytometry/Cell sorting to study the effects of physiological expression of a C-terminal truncated AsXenopus laevis1 mutant in vivo.
Mon Jun 04 00:00:00 EDT 2018
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation.
Frontiers in immunology
Quinn JL,Kumar G,Agasing A,Ko RM,Axtell RC
12-0452 was used in Flow cytometry/Cell sorting to study how T and B cells cooperate in the pathogenesis of multiple sclerosis.
Mon Apr 08 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
12-0452-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Mar 15 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Betaine Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Dendritic Cell-Derived IL-6 Production and Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Yang C,Lai W,Zhou J,Zheng X,Cai Y,Yang W,Xie S,Gao Y,Du C
12-0452 was used in Flow cytometry/Cell sorting to demonstrate the pivotal roles of betaine in modulating MS pathogenesis and suggested that it may serve as a potential novel drug candidate for the treatment of MS.
Thu Feb 15 00:00:00 EST 2018
Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells.
Experimental hematology
Shi X,Kitano A,Jiang Y,Luu V,Hoegenauer KA,Nakada D
12-0452 was used in Flow cytometry/Cell sorting to establish that the CRISPR/Cas9-mediated multiplex mutagenesis can be used to engineer a variety of murine models of hematological malignancies with complex genetic architectures seen in human disease.
Wed Aug 01 00:00:00 EDT 2018
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Experimental and therapeutic medicine
Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.
Frontiers in immunology
Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Sep 26 00:00:00 EDT 2019
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
12-0452 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.
Oncotarget
Mertens B,Cristina de Araujo Nogueira T,Topalis D,Stranska R,Snoeck R,Andrei G
12-0452 was used in Flow cytometry/Cell sorting to identify the potential use of cidofovir in therapeutic strategies to kill tumour cells and influence the immune system to fight cancer.
Tue Apr 24 00:00:00 EDT 2018
Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice.
Genome biology
Duan J,Lu G,Hong Y,Hu Q,Mai X,Guo J,Si X,Wang F,Zhang Y
12-0452 was used in Flow cytometry/Cell sorting to generate and characterise a mouse strain with dCas9-EGFP ubiquitously expressed in various tissues.
Thu Nov 08 00:00:00 EST 2018
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Cell
Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC
12-0452 was used in Flow cytometry/Cell sorting to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.
Thu Mar 09 00:00:00 EST 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
12-0452 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
12-0452 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.
Pulmonary circulation
Gaskill C,Majka SM
12-0452 was used in Flow cytometry/Cell sorting to describe a protocol to select large quantities of enriched primary human lung microvascular endothelial cells, free from mesenchymal contamination.
Wed Mar 01 00:00:00 EST 2017
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2017
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nature communications
Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
JCI insight
Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
PloS one
Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination.
Nature communications
Zan H,Tat C,Qiu Z,Taylor JR,Guerrero JA,Shen T,Casali P
12-0452 was used in Flow cytometry/Cell sorting to show that Rad52 competes with Ku for binding to S-region DSB free ends.
Wed Feb 08 00:00:00 EST 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
12-0452 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.
Mon Feb 06 00:00:00 EST 2017
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.
PloS one
Patel B,Ismahil MA,Hamid T,Bansal SS,Prabhu SD
12-0452 was used in Flow cytometry/Cell sorting to assess for alterations in MPs.
Thu Aug 10 00:00:00 EDT 2017
Ceramide synthesis regulates T cell activity and GVHD development.
JCI insight
Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ
12-0452 was used in Flow cytometry/Cell sorting to define the involvement of ceramides in the T-cell response to alloantigens present after allogeneic haematopoietic cell transplantation.
Thu May 18 00:00:00 EDT 2017
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
12-0452 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation.
The Journal of clinical investigation
Nguyen HD,Chatterjee S,Haarberg KM,Wu Y,Bastian D,Heinrichs J,Fu J,Daenthanasanmak A,Schutt S,Shrestha S,Liu C,Wang H,Chi H,Mehrotra S,Yu XZ
12-0452 was used in Flow cytometry/Cell sorting to study the metabolic reprogramming of donor T cells following allogeneic haematopoietic cell transplantation.
Fri Apr 01 00:00:00 EDT 2016
NLRP2 controls age-associated maternal fertility.
The Journal of experimental medicine
Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M
12-0452 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.
Mon Dec 12 00:00:00 EST 2016
Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Bajwa A,Huang L,Kurmaeva E,Gigliotti JC,Ye H,Miller J,Rosin DL,Lobo PI,Okusa MD
12-0452 was used in Immunohistochemistry to test the therapeutic advantage of S1pr32/2 bone marrow-derived dendritic cell transfers in kidney ischemia-reperfusion injury.
Fri Apr 01 00:00:00 EDT 2016
Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.
Frontiers in immunology
Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE
12-0452 was used in Flow cytometry/Cell sorting to show that blocking the intrinsic apoptosis pathway with a Bcl-2/Bcl-xL inhibitor (ABT-737) caused a selective depletion of effector T cells and a relative enrichment of Tregs in vivo.
Mon Mar 14 00:00:00 EDT 2016
Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile.
Arthritis research & therapy
van der Velden D,Lagraauw HM,Wezel A,Launay P,Kuiper J,Huizinga TW,Toes RE,Bot I,Stoop JN
12-0452 was used in Flow cytometry/Cell sorting to suggest that mast cells may play a role in the regulation of the adaptive immune response during the development of arthritis.
Mon Jun 13 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models.
Experimental eye research
Liyanage SE,Gardner PJ,Ribeiro J,Cristante E,Sampson RD,Luhmann UF,Ali RR,Bainbridge JW
12-0452 was used in Flow cytometry/Cell sorting to demonstrate a standardised method for the identification and quantification of myeloid cells in diseased tissues.
Sat Oct 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.
Nature communications
Du C,Duan Y,Wei W,Cai Y,Chai H,Lv J,Du X,Zhu J,Xie X
12-0452 was used in Flow cytometry/Cell sorting to show that kappa opioid receptor activation alleviates autoimmune encephalomyelitis and promotes remyelination..
Mon Apr 04 00:00:00 EDT 2016
Enhancement of Oral Tolerance Induction in DO11.10 Mice by Lactobacillus gasseri OLL2809 via Increase of Effector Regulatory T Cells.
PloS one
Aoki-Yoshida A,Yamada K,Hachimura S,Sashihara T,Ikegami S,Shimizu M,Totsuka M
12-0452 was used in Flow cytometry/Cell sorting to evaluate how oral administration of the probiotic LG2809 influences immune cells in an induced oral tolerance mouse model.
Wed Aug 02 00:00:00 EDT 2017
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
12-0452 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
12-0452 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
The development of mixed cryoglobulinemia in Capillaria hepatica-infected mice is associated with the capillaria antigen-induced selective proliferation of splenic B-1a cells in response to interleukin-5 stimulation.
The American journal of pathology
Aihara N,Kamiie J,Yamada M,Shirota K
12-0452 was used in Flow cytometry/Cell sorting to show that type II mixed cryoglobulinemia is induced by Capillaria hepatica infection through a mechanism in which splenic B-1a cells reacting to C.
Thu Jan 01 00:00:00 EST 2015
B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent.
Infection and immunity
Hoyt TR,Dobrinen E,Kochetkova I,Meissner N
12-0452 was used in Flow cytometry/Cell sorting to show how B cells promote the replenishment of depleted bone marrow cells during systemic responses to Pneumocystis lung infection.
Sun Feb 01 00:00:00 EST 2015
Endothelial Gata5 transcription factor regulates blood pressure.
Nature communications
Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Nov 30 00:00:00 EST 2015
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.
Nature communications
Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Jun 24 00:00:00 EDT 2015
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
PloS one
Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA
12-0452 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.
Tue Apr 19 00:00:00 EDT 2016
The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.
PloS one
Vettermann C,Timblin GA,Lim V,Lai EC,Schlissel MS
12-0452 was used in Flow cytometry/Cell sorting to identify the proximal GT promoter as the first cis-element known to regulate the internal order of Jκ rearrangements.
Tue Jan 26 00:00:00 EST 2016
Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma.
Nature communications
Lee CL,Castle KD,Moding EJ,Blum JM,Williams N,Luo L,Ma Y,Borst LB,Kim Y,Kirsch DG
12-0452 was used in Flow cytometry/Cell sorting to show that total-body irradiation promotes the expansion of a rare population of thymocytes that express oncogenic Kras(G12D).
Thu Sep 24 00:00:00 EDT 2015
Acquired initiating mutations in early hematopoietic cells of CLL patients.
Cancer discovery
Damm F,Mylonas E,Cosson A,Yoshida K,Della Valle V,Mouly E,Diop M,Scourzic L,Shiraishi Y,Chiba K,Tanaka H,Miyano S,Kikushige Y,Davi F,Lambert J,Gautheret D,Merle-Béral H,Sutton L,Dessen P,Solary E,Akashi K,Vainchenker W,Mercher T,Droin N,Ogawa S,Nguyen-Khac F,Bernard OA
12-0452 was used in Flow cytometry/Cell sorting to study the presence of mutations in multipotent hematopoietic progenitors from patients with chronic lymphocytic leukemia.
Mon Sep 01 00:00:00 EDT 2014
TLR7 ligand augments GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells.
Cancer immunology research
Narusawa M,Inoue H,Sakamoto C,Matsumura Y,Takahashi A,Inoue T,Watanabe A,Miyamoto S,Miura Y,Hijikata Y,Tanaka Y,Inoue M,Takayama K,Okazaki T,Hasegawa M,Nakanishi Y,Tani K
12-0452 was used in Flow cytometry/Cell sorting to study how the additional use of imiquimod to activate plasmacytoid dendritic cells with type I IFN production could enhance the immunologic antitumor effects of GVAX therapy.
Sun Jun 01 00:00:00 EDT 2014
Age-dependent enterocyte invasion and microcolony formation by Salmonella.
PLoS pathogens
Zhang K,Dupont A,Torow N,Gohde F,Leschner S,Lienenklaus S,Weiss S,Brinkmann MM,Kühnel M,Hensel M,Fulde M,Hornef MW
12-0452 was used in Flow cytometry/Cell sorting to provide important insight in the early steps of Salmonella infection in vivo.
Mon Sep 01 00:00:00 EDT 2014
The Vi capsular polysaccharide enables Salmonella enterica serovar typhi to evade microbe-guided neutrophil chemotaxis.
PLoS pathogens
Wangdi T,Lee CY,Spees AM,Yu C,Kingsbury DD,Winter SE,Hastey CJ,Wilson RP,Heinrich V,Bäumler AJ
12-0452 was used in Flow cytometry/Cell sorting to study how the expression of the Vi capsular polysaccharide of S. Typhi obstructs bacterial-guided neutrophil chemotaxis.
Fri Aug 01 00:00:00 EDT 2014
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Journal of immunology (Baltimore, Md. : 1950)
Park KS,Bayles I,Szlachta-McGinn A,Paul J,Boiko J,Santos P,Liu J,Wang Z,Borghesi L,Milcarek C
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Sat Nov 01 00:00:00 EDT 2014
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Journal of immunology (Baltimore, Md. : 1950)
Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Apr 01 00:00:00 EDT 2014
Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Mercadante AC,Perobelli SM,Alves AP,Gonçalves-Silva T,Mello W,Gomes-Santos AC,Miyoshi A,Azevedo V,Faria AM,Bonomo A
12-0452 was used in Flow cytometry/Cell sorting to suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of graft-versus-leukemia in allogenic HSCT.
Sat Feb 15 00:00:00 EST 2014
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
White CA,Pone EJ,Lam T,Tat C,Hayama KL,Li G,Zan H,Casali P
12-0452 was used in Flow cytometry/Cell sorting to study the epigenetic mechanisms which modulate expression of proteins involved in B cell differentiation and autoimmunity..
Mon Dec 15 00:00:00 EST 2014
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
White CA,Pone EJ,Lam T,Tat C,Hayama KL,Li G,Zan H,Casali P
12-0452 was used in Flow cytometry/Cell sorting to study the epigenetic mechanisms which modulate expression of proteins involved in B cell differentiation and autoimmunity..
Mon Dec 15 00:00:00 EST 2014
TRAF6 is a critical regulator of LMP1 functions in vivo.
International immunology
Arcipowski KM,Stunz LL,Bishop GA
12-0452 was used in Flow cytometry/Cell sorting to investigate TRAF6 as a critical regulator of LMP1 versus CD40 specific B-cell functions in TRAF6-deficient mice.
Sat Mar 01 00:00:00 EST 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-0452 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Targeting multiple types of tumors using NKG2D-coated iron oxide nanoparticles.
Nanotechnology
Wu MR,Cook WJ,Zhang T,Sentman CL
12-0452 was used in Flow cytometry/Cell sorting to develop NKG2D-expressing iron oxide nanoparticles, enabling the targeting of multiple tumour types.
Fri Nov 28 00:00:00 EST 2014
Rhof promotes murine marginal zone B cell development.
Nagoya journal of medical science
Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Aug 01 00:00:00 EDT 2014
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
PloS one
Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
Lactobacillus gasseri SBT2055 induces TGF-β expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine.
PloS one
Sakai F,Hosoya T,Ono-Ohmachi A,Ukibe K,Ogawa A,Moriya T,Kadooka Y,Shiozaki T,Nakagawa H,Nakayama Y,Miyazaki T
12-0452 was used in Flow cytometry/Cell sorting to find that oral administration of LG2055 induced IgA production and increased the rate of IgA(+) cell population in Peyer's patch and in the lamina propria of the mouse small intestine.
Thu May 14 00:00:00 EDT 2015
Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection.
Nature communications
Tamburini BA,Burchill MA,Kedl RM
12-0452 was used in Flow cytometry/Cell sorting to better understand the role for persisting antigen in both vaccine and infectious settings, which could impact future vaccination strategies.
Fri Jun 06 00:00:00 EDT 2014
B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.
Nature medicine
Zouggari Y,Ait-Oufella H,Bonnin P,Simon T,Sage AP,Guérin C,Vilar J,Caligiuri G,Tsiantoulas D,Laurans L,Dumeau E,Kotti S,Bruneval P,Charo IF,Binder CJ,Danchin N,Tedgui A,Tedder TF,Silvestre JS,Mallat Z
12-0452 was used in Flow cytometry/Cell sorting to identify the interaction between mature B lymphocytes and monocytes as a potential therapeutic target after a heart attack.
Tue Oct 01 00:00:00 EDT 2013
Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Nature
Adorno M,Sikandar S,Mitra SS,Kuo A,Nicolis Di Robilant B,Haro-Acosta V,Ouadah Y,Quarta M,Rodriguez J,Qian D,Reddy VM,Cheshier S,Garner CC,Clarke MF
12-0452 was used in Flow cytometry/Cell sorting to demonstrate a role for USP16 in antagonising the self-renewal and senescence pathways in Down's syndrome.
Thu Sep 19 00:00:00 EDT 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
12-0452 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 EST 2013
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
12-0452 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8+ T-cell responses.
Molecular therapy : the journal of the American Society of Gene Therapy
Dietz WM,Skinner NE,Hamilton SE,Jund MD,Heitfeld SM,Litterman AJ,Hwu P,Chen ZY,Salazar AM,Ohlfest JR,Blazar BR,Pennell CA,Osborn MJ
12-0452 was used in Flow cytometry/Cell sorting to determine that intradermal delivery of minicircle DNA may prove more efficacious for prophylaxis than traditional pDNA vaccines.
Thu Aug 01 00:00:00 EDT 2013
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice.
European journal of immunology
Yu Y,Wang D,Kaosaard K,Liu C,Fu J,Haarberg K,Anasetti C,Beg AA,Yu XZ
12-0452 was used in Flow cytometry/Cell sorting to investigate the role of c-Rel in transplant tolerance and graft-versus-host disease (GVHD), showing that it is an essential transcription factor for the development of acute GVHD.
Sun Sep 01 00:00:00 EDT 2013
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.
Journal of leukocyte biology
Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ
12-0452 was used in Flow cytometry/Cell sorting to develop a novel murine strain to allow a better definition of the role of eosinophils in health and disease.
Mon Jul 01 00:00:00 EDT 2013
Novel apidaecin 1b analogs with superior serum stabilities for treatment of infections by gram-negative pathogens.
Antimicrobial agents and chemotherapy
Berthold N,Czihal P,Fritsche S,Sauer U,Schiffer G,Knappe D,Alber G,Hoffmann R
12-0452 was used in Flow cytometry/Cell sorting to study the effect of modifications to the C-terminus of Api88 on its rate of proteolysis.
Tue Jan 01 00:00:00 EST 2013
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kipari T,Hadoke PW,Iqbal J,Man TY,Miller E,Coutinho AE,Zhang Z,Sullivan KM,Mitic T,Livingstone DE,Schrecker C,Samuel K,White CI,Bouhlel MA,Chinetti-Gbaguidi G,Staels B,Andrew R,Walker BR,Savill JS,Chapman KE,Seckl JR
12-0452 was used in Flow cytometry/Cell sorting to determine the effects of 11Β-Hydroxysteroid dehydrogenase type-1 deficiency on atherosclerosis and its inflammation.
Mon Apr 01 00:00:00 EDT 2013
IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.
Journal of immunology (Baltimore, Md. : 1950)
Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST
12-0452 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.
Sun Sep 01 00:00:00 EDT 2013
Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces.
Journal of immunology (Baltimore, Md. : 1950)
Nam G,Lee YK,Lee HY,Ma MJ,Araki M,Araki K,Lee S,Lee IS,Choi EY
12-0452 was used in Flow cytometry/Cell sorting to explore the interaction between mouse CD99 and its paralog CD99-like 2, and the consequences of this interaction.
Sun Dec 01 00:00:00 EST 2013
Candida albicans stimulates in vivo differentiation of haematopoietic stem and progenitor cells towards macrophages by a TLR2-dependent signalling.
Cellular microbiology
Megías J,Maneu V,Salvador P,Gozalbo D,Gil ML
12-0452 was used in Flow cytometry/Cell sorting to report that haematopoietic stem and progenitor cells sense Candida albicans in vivo and subsequently are directed to produce macrophages by a Toll like receptor 2-dependent signalling.
Mon Jul 01 00:00:00 EDT 2013
Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Dighe AS,Yang S,Madhu V,Balian G,Cui Q
12-0452 was used in Flow cytometry/Cell sorting to investigate whether MSCs can be used for bone repair, showing that interferon gamma and T cells inhibit osteogenesis induced by allogeneic MSCs.
Fri Feb 01 00:00:00 EST 2013
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu Jun 13 00:00:00 EDT 2013
Properties of immature myeloid progenitors with nitric-oxide-dependent immunosuppressive activity isolated from bone marrow of tumor-free mice.
PloS one
Forghani P,Harris W,Giver CR,Mirshafiey A,Galipeau J,Waller EK
12-0452 was used in Flow cytometry/Cell sorting to determine the role of immature myeloid cells in regulating T-cell activation and proliferation in bone marrow.
Thu Jan 23 00:00:00 EST 2014
Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration.
mBio
Spees AM,Wangdi T,Lopez CA,Kingsbury DD,Xavier MN,Winter SE,Tsolis RM,Bäumler AJ
12-0452 was used in Flow cytometry/Cell sorting to identify streptomycin-induced changes in the gut that lower resistance to colonisation by facultative anaerobic bacteria.
Tue Jul 02 00:00:00 EDT 2013
Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease.
Clinical & developmental immunology
Legorreta-Haquet MV,Flores-Fernández R,Blanco-Favela F,Fuentes-Pananá EM,Chávez-Sánchez L,Hernández-González R,Tesoro-Cruz E,Arriaga-Pizano L,Chávez-Rueda AK
12-0452 was used in Flow cytometry/Cell sorting to determine the level of PRL receptor expression during bone-marrow B-cell development and assess relevance in disease outcomes in lupus-prone murine models.
Mon Aug 04 00:00:00 EDT 2014
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
12-0452 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood
Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J
12-0452 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.
Thu Mar 08 00:00:00 EST 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
12-0452-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Cellular & molecular immunology
Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L
12-0452 was used in Flow cytometry/Cell sorting to provide a novel understanding of the interaction between iTregs and DCs, and its role in iTreg-mediated immune suppression.
Thu Mar 01 00:00:00 EST 2012
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
Journal of leukocyte biology
Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E
12-0452 was used in Flow cytometry/Cell sorting to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.
Thu Nov 01 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites.
The Journal of biological chemistry
Gomez IG,Tang J,Wilson CL,Yan W,Heinecke JW,Harlan JM,Raines EW
12-0452 was used in Flow cytometry/Cell sorting to investigate peritonitis-elevated levels of integrin β2 at times when macrophages are exiting the peritoneum.
Fri Feb 10 00:00:00 EST 2012
Role of suppressor of cytokine signaling-1 in murine atherosclerosis.
PloS one
Grothusen C,Schuett H,Hillmer A,Lumpe S,Grote K,Ballmaier M,Bleich A,Glage S,Tietge UJ,Luchtefeld M,Schieffer B
12-0452 was used in Flow cytometry/Cell sorting to investigate the impact of systemic SOCS-1 deficiency on atherogenesis in the low-density lipoprotein receptor deficient murine model of atherosclerosis.
Wed Jul 17 00:00:00 EDT 2013
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions.
Nature immunology
Maul RW,Saribasak H,Martomo SA,McClure RL,Yang W,Vaisman A,Gramlich HS,Schatz DG,Woodgate R,Wilson DM,Gearhart PJ
12-0452 was used in Flow cytometry/Cell sorting to provide direct evidence for the model that AID functions by deaminating cytosine residues in DNA.
Sat Jan 01 00:00:00 EST 2011
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
Blood
Yu Y,Wang D,Liu C,Kaosaard K,Semple K,Anasetti C,Yu XZ
12-0452 was used in Flow cytometry/Cell sorting to indicate that GVHD can be prevented by targeting Th1 and Th17 transcription factors without offsetting GVL activity.
Thu Nov 03 00:00:00 EDT 2011
Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells.
Cellular & molecular immunology
Liu L,Duan L,Gong M,Dai H,Gong Q,Zheng F,Tan Z,Wang C,Gong F,Fang M
12-0452 was used in Flow cytometry/Cell sorting to suggest that donor-derived splenic stromal cells could be used as a therapeutic target to promote transplantation tolerance.
Sat Jan 01 00:00:00 EST 2011
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.
PLoS pathogens
Eitz Ferrer P,Potthoff S,Kirschnek S,Gasteiger G,Kastenmüller W,Ludwig H,Paschen SA,Villunger A,Sutter G,Drexler I,Häcker G
12-0452 was used in Immunocytochemistry to describe a pathway from viral RNA detection during infection to Noxa up-regulation and apoptosis via IRF3 and type I IFN signalling.
Wed Jun 01 00:00:00 EDT 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
12-0452 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.
Thu Dec 15 00:00:00 EST 2011
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Wang L,Du C,Lv J,Wei W,Cui Y,Xie X
12-0452 was used in Flow cytometry/Cell sorting to investigate how anti-asthmatic drugs targeting the cysteinyl leukotrine receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis.
Thu Sep 01 00:00:00 EDT 2011
Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice.
International immunology
Keszei M,Latchman YE,Vanguri VK,Brown DR,Detre C,Morra M,Arancibia-Carcamo CV,Paul E,Calpe S,Castro W,Wang N,Terhorst C,Sharpe AH
12-0452 was used in Flow cytometry/Cell sorting to demonstrate that the Slamf2-/- mutation may have a unique influence on T-cell tolerance and lupus.
Tue Feb 01 00:00:00 EST 2011
mGluR6 transcripts in non-neuronal tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Vardi T,Fina M,Zhang L,Dhingra A,Vardi N
12-0452 was used in Flow cytometry/Cell sorting to study mGluR6 expression by investigating two transgenic mouse lines that express enhanced GFP under control of mGluR6 promoter.
Thu Dec 01 00:00:00 EST 2011
AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4.
Autoimmunity
White CA,Seth Hawkins J,Pone EJ,Yu ES,Al-Qahtani A,Mai T,Zan H,Casali P
12-0452 was used in Flow cytometry/Cell sorting to demonstrate the upregulation of HoxC4 and activation-induced cytidine deaminase expression in systemic lupus erythematosus.
Thu Dec 01 00:00:00 EST 2011
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.
PloS one
Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2011
Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.
PloS one
Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML
12-0452 was used in Flow cytometry/Cell sorting to investigate how C. albicans invasive infection with a low virulence strain results in a rapid expansion of HSPCs.
Tue Feb 28 00:00:00 EST 2012
Study of camelpox virus pathogenesis in athymic nude mice.
PloS one
Duraffour S,Matthys P,van den Oord JJ,De Schutter T,Mitera T,Snoeck R,Andrei G
12-0452 was used in Flow cytometry/Cell sorting to confirm that NMRI immunocompetent mice are resistant to intranasal (i.n.) CMLV infection.
Thu Dec 01 00:00:00 EST 2011
CONTINUOUS REPOPULATION OF LYMPHOCYTE SUBSETS IN TRANSPLANTED MYCOBACTERIAL GRANULOMAS.
European journal of microbiology & immunology
Schreiber HA,Harding JS,Altamirano CJ,Hunt O,Hulseberg PD,Fabry Z,Sandor M
12-0452 was used in Flow cytometry/Cell sorting to study the composition of transplanted mycobacterial granulomas.
Tue Mar 01 00:00:00 EST 2011
Protein kinase D2 is an essential regulator of murine myoblast differentiation.
PloS one
Kleger A,Loebnitz C,Pusapati GV,Armacki M,Müller M,Tümpel S,Illing A,Hartmann D,Brunner C,Liebau S,Rudolph KL,Adler G,Seufferlein T
12-0452 was used in Flow cytometry/Cell sorting to identify protein kinase D2 as a major mediator of muscle cell differentiation in vitro and a potential novel target for the modulation of muscle regeneration.
Thu Jan 27 00:00:00 EST 2011
Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis.
Molecular & cellular proteomics : MCP
Ficarro SB,Zhang Y,Carrasco-Alfonso MJ,Garg B,Adelmant G,Webber JT,Luckey CJ,Marto JA
12-0452 was used in Flow cytometry/Cell sorting to explore two novel multidimensional fractionation strategies for the gathering of phosphoproteomics data.
Tue Nov 01 00:00:00 EDT 2011
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.
Nature immunology
Capasso M,Bhamrah MK,Henley T,Boyd RS,Langlais C,Cain K,Dinsdale D,Pulford K,Khan M,Musset B,Cherny VV,Morgan D,Gascoyne RD,Vigorito E,DeCoursey TE,MacLennan IC,Dyer MJ
12-0452 was used in Flow cytometry/Cell sorting to investigate how HVCN1 modulates BCR signal strength through regulation of BCR-dependent generation of reactive oxygen species.
Mon Mar 01 00:00:00 EST 2010
TLR8 deficiency leads to autoimmunity in mice.
The Journal of clinical investigation
Demaria O,Pagni PP,Traub S,de Gassart A,Branzk N,Murphy AJ,Valenzuela DM,Yancopoulos GD,Flavell RA,Alexopoulou L
12-0452 was used in Flow cytometry/Cell sorting to explore the relationship between TLR8 and TLR7 and autoimmunity in mice.
Fri Oct 01 00:00:00 EDT 2010
B cell depletion reduces the development of atherosclerosis in mice.
The Journal of experimental medicine
Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z
12-0452 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.
Mon Aug 02 00:00:00 EDT 2010
Impaired apoptotic cell clearance in the germinal center by Mer-deficient tingible body macrophages leads to enhanced antibody-forming cell and germinal center responses.
Journal of immunology (Baltimore, Md. : 1950)
Rahman ZS,Shao WH,Khan TN,Zhen Y,Cohen PL
12-0452 was used in Flow cytometry/Cell sorting to demonstrate a critical role for Mer in GC apoptotic cell clearance by TBMΦs.
Mon Nov 15 00:00:00 EST 2010
CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors.
Journal of immunology (Baltimore, Md. : 1950)
Haynes NM,Hawkins ED,Li M,McLaughlin NM,Hämmerling GJ,Schwendener R,Winoto A,Wensky A,Yagita H,Takeda K,Kershaw MH,Darcy PK,Smyth MJ
12-0452 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms contributing to the antitumour activity of selective antagonism of death receptors 4 and 5, showing that CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy.
Thu Jul 01 00:00:00 EDT 2010
Increased hematopoietic cells in the mertk-/- mouse peritoneal cavity: a result of augmented migration.
Journal of immunology (Baltimore, Md. : 1950)
Williams JC,Wagner NJ,Earp HS,Vilen BJ,Matsushima GK
12-0452 was used in Flow cytometry/Cell sorting to investigate whether Mertk regulates the composition of peritoneal cells that favour an autoimmune phenotype.
Tue Jun 15 00:00:00 EDT 2010
CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1.
Infection and immunity
Charles E,Joshi S,Ash JD,Fox BA,Farris AD,Bzik DJ,Lang ML,Blader IJ
12-0452 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the retina protects itself from CD4 T-cell-mediated immune damage in retinal immune responses.
Sun Aug 01 00:00:00 EDT 2010
Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.
The Journal of biological chemistry
Mai T,Zan H,Zhang J,Hawkins JS,Xu Z,Casali P
12-0452 was used in Flow cytometry/Cell sorting to investigate whether estrogen indirectly regulates AID expression in B cells through activation of the HOXC4/HoxC4 promoter.
Fri Nov 26 00:00:00 EST 2010
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Nature immunology
Park SR,Zan H,Pal Z,Zhang J,Al-Qahtani A,Pone EJ,Xu Z,Mai T,Casali P
12-0452 was used in Flow cytometry/Cell sorting to show that HoxC4 directly activates the Aicda promoter, thereby inducing AID expression, class-switch DNA recombination and somatic hypermutation.
Fri May 01 00:00:00 EDT 2009
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.
Blood
Nakayama J,Yamamoto M,Hayashi K,Satoh H,Bundo K,Kubo M,Goitsuka R,Farrar MA,Kitamura D
12-0452 was used in Flow cytometry/Cell sorting to demonstrate that BLNK normally regulates IL-7-dependent proliferation and survival of pre-B cells through direct inhibition of JAK3.
Thu Feb 12 00:00:00 EST 2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
The Journal of experimental medicine
Lee HK,Zamora M,Linehan MM,Iijima N,Gonzalez D,Haberman A,Iwasaki A
12-0452 was used in Flow cytometry/Cell sorting to to study the differential roles of migratory and resident DC's in T cell priming after mucosal or skin HSV-1 infection.
Mon Feb 16 00:00:00 EST 2009
STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.
Haematologica
Thawani N,Tam M,Stevenson MM
12-0452 was used in Flow cytometry/Cell sorting to investigate the role of STAT6-mediated responses in erythropoietic suppression during acute malaria infection in mice.
Sun Feb 01 00:00:00 EST 2009
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.
European journal of immunology
Aoshi T,Carrero JA,Konjufca V,Koide Y,Unanue ER,Miller MJ
12-0452 was used in Immunohistochemistry to illustrate the changeable nature of the cellular niche of Listeria monocytogenes.
Sun Feb 01 00:00:00 EST 2009
4-1BB functions as a survival factor in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS
12-0452 was used in Immunofluorescence on frozen tissues to investigate the function of CD137 on dendritic cells, showing that it functions as a survival factor.
Wed Apr 01 00:00:00 EDT 2009
Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.
Infection and immunity
Zhou X,Chen Q,Moore J,Kolls JK,Halperin S,Wang J
12-0452 was used in Flow cytometry/Cell sorting to demonstrate that Chlamydia stimulates IL-17/IL-17R-associated responses in Chlamydia-resistant and Chlamydia-susceptible mice.
Sun Nov 01 00:00:00 EDT 2009
Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.
Autoimmunity
Zan H,Zhang J,Ardeshna S,Xu Z,Park SR,Casali P
12-0452 was used in Flow cytometry/Cell sorting to demonstrate that SHM and CSR are dysregulated in lupus-prone mice, as a result of enhanced AID expression.
Sun Feb 01 00:00:00 EST 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
12-0452 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Kasai H,Watanabe A,Lai AY,Kondo M
12-0452 was used in Flow cytometry/Cell sorting to investigate when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice, showing that IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Tue Jul 01 00:00:00 EDT 2008
Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen.
Journal of immunological methods
Jakubzick C,Helft J,Kaplan TJ,Randolph GJ
12-0452 was used in Flow cytometry/Cell sorting to investigate the best approaches to study dendritic cell migration to lung-draining lymph nodes in mice.
Mon Sep 15 00:00:00 EDT 2008
p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
PloS one
Cheng N,van de Wetering CI,Knudson CM
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Apr 02 00:00:00 EDT 2008
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
12-0452-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2007
STAT3 positively regulates an early step in B-cell development.
Blood
Chou WC,Levy DE,Lee CK
12-0452 was used in Flow cytometry/Cell sorting to study the transcription factors required for B lymphocyte development from progenitors in the bone marrow, showing that STAT3 positively regulates an early step in B-cell development.
Wed Nov 01 00:00:00 EST 2006
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Molecular and cellular biology
Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2006
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction.
Molecular and cellular biology
Dai X,Chen Y,Schuman J,Hua Z,Adamson JW,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2006
A role for brain-derived neurotrophic factor in B cell development.
Journal of neuroimmunology
Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA
Wed Jun 01 00:00:00 EDT 2005
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
Molecular and cellular biology
Pan L,Sato S,Frederick JP,Sun XH,Zhuang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 12-0452-82) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 1999
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-RA3-6B2-RE-AV-20170920122035.jpg?time=20240507?time=20240507 "CD45R (B220) Antibody (12-0452-82)")
