Invitrogen

CD45R (B220) Monoclonal Antibody (RA3-6B2), eFluor™ 615, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

35 Published Figures

42 References

View all (99) B220 (CD45R) antibodies

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Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

CD45R (B220) Antibody in Immunohistochemistry (Frozen) (IHC (F))

FIGURE: 1 / 37

CD45R (B220) Antibody (42-0452-82) in IHC (F)

Immunohistochemistry on frozen mouse spleen using 1 µg/mL Rat IgG2a K Isotype Control eFluor® 615 (left) or 1 µg/mL Anti-Human/Mouse CD45R (B220) eFluor® 615 (right). Nuclei are counterstained with DAPI.

CD45R (B220) Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

CD45R (B220) Antibody in Immunocytochemistry (ICC/IF)

CD45R (B220) Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

CD45R (B220) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD45R (B220) Antibody in Immunohistochemistry (IHC)

CD45R (B220) Antibody in Flow Cytometry (Flow)

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Product Details

42-0452-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 29 publications 29 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

1 µg/mL

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

Assay-Dependent

View 6 publications 6 publications

Flow Cytometry (Flow)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), eFluor™ 615, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

RA3-6B2

Conjugate

eFluor™ 615 eFluor™ 615 eFluor™ 615

Excitation/Emission Max

595/614 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10852702

Product Specific Information

Description: The RA3-6B2 monoclonal antibody reacts with exon A-restricted isoform of mouse CD45, a 220 kDa surface molecule. CD45R/B220 epitope is mainly expressed by the B cell lineage from early Pro-B to mature B cells. However, some activated T cells, lymphokine activated killer cells (LAK), NK cell progenitors in the bone marrow, and T cells of the lpr/lpr mutant mouse also express this antigen.

Applications Reported: This RA3-6B2 antibody has been reported for use in immunohistochemical staining of frozen tissue sections (IHC-F), and immunocytochemistry.

Applications Tested: This RA3-6B2 antibody has been tested by immunohistochemistry on frozen mouse spleen at less than or equal to 1 µg/mL. It is recommended that this antibody be carefully titrated for optimal performance in the assay of interest. This product has not been validated for flow cytometric analysis.

Filter Recommendation: When using this eFluor® 615 antibody conjugate, we recommend a filter that will capture the 615 emission wavelength (for example, Excitation 560/55, 585LP, Emission 645/75). A standard Alexa Fluor® 594 filter is acceptable.

Excitation: 595 nm; Emission: 615 nm.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.

Mucosal immunology

Richmond BW,Mansouri S,Serezani A,Novitskiy S,Blackburn JB,Du RH,Fuseini H,Gutor S,Han W,Schaff J,Vasiukov G,Xin MK,Newcomb DC,Jin L,Blackwell TS,Polosukhin VV

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon Mar 01 00:00:00 EST 2021

Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.

Disease models & mechanisms

Dobosz E,Lorenz G,Ribeiro A,Würf V,Wadowska M,Kotlinowski J,Schmaderer C,Potempa J,Fu M,Koziel J,Lech M

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Thu Mar 18 00:00:00 EDT 2021

Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection.

Frontiers in immunology

Guo L,Li N,Yang Z,Li H,Zheng H,Yang J,Chen Y,Zhao X,Mei J,Shi H,Worthen GS,Liu L

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Tue Feb 08 00:00:00 EST 2022

Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia.

Cell death & disease

Zaccagnini G,Greco S,Longo M,Maimone B,Voellenkle C,Fuschi P,Carrara M,Creo P,Maselli D,Tirone M,Mazzone M,Gaetano C,Spinetti G,Martelli F

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Sat May 01 00:00:00 EDT 2021

Ibrutinib does not prevent kidney fibrosis following acute and chronic injury.

Scientific reports

Belliere J,Casemayou A,Colliou E,El Hachem H,Kounde C,Piedrafita A,Feuillet G,Schanstra JP,Faguer S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon Jun 07 00:00:00 EDT 2021

High-throughput analysis of lung immune cells in a combined murine model of agriculture dust-triggered airway inflammation with rheumatoid arthritis.

PloS one

Gaurav R,Mikuls TR,Thiele GM,Nelson AJ,Niu M,Guda C,Eudy JD,Barry AE,Wyatt TA,Romberger DJ,Duryee MJ,England BR,Poole JA

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Thu Jul 08 00:00:00 EDT 2021

Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.

Life science alliance

Mendes A,Gigan JP,Rodriguez Rodrigues C,Choteau SA,Sanseau D,Barros D,Almeida C,Camosseto V,Chasson L,Paton AW,Paton JC,Argüello RJ,Lennon-Duménil AM,Gatti E,Pierre P

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon Feb 01 00:00:00 EST 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Thu Oct 07 00:00:00 EDT 2021

Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation.

eLife

Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Protein Assays and Analysis

Thu Dec 02 00:00:00 EST 2021

Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants.

Science advances

Zhang YN,Paynter J,Sou C,Fourfouris T,Wang Y,Abraham C,Ngo T,Zhang Y,He L,Zhu J

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry (Frozen)

Fri Oct 22 00:00:00 EDT 2021

Synergistic factors control kinase-phosphatase organization in B-cells engaged with supported bilayers.

Molecular biology of the cell

Núñez MF,Wisser K,Veatch SL

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunocytochemistry

Thu Mar 19 00:00:00 EDT 2020

Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice.

Pathogens (Basel, Switzerland)

Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Tamas A,Reglodi D,Bereswill S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry (Paraffin)

Wed Sep 30 00:00:00 EDT 2020

Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice.

Pathogens (Basel, Switzerland)

Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Tamas A,Reglodi D,Bereswill S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry (Paraffin)

Wed Sep 30 00:00:00 EDT 2020

Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota.

Pathogens (Basel, Switzerland)

Kløve S,Genger C,Mousavi S,Weschka D,Bereswill S,Heimesaat MM

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon May 18 00:00:00 EDT 2020

Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation.

Frontiers in immunology

Kreimann K,Jang MS,Rong S,Greite R,von Vietinghoff S,Schmitt R,Bräsen JH,Schiffer L,Gerstenberg J,Vijayan V,Dittrich-Breiholz O,Wang L,Karsten CM,Gwinner W,Haller H,Immenschuh S,Gueler F

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon Apr 12 00:00:00 EDT 2021

Overcoming Immunological Challenges to Helper-Dependent Adenoviral Vector-Mediated Long-Term CFTR Expression in Mouse Airways.

Genes

Cao H,Duan R,Hu J

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon May 18 00:00:00 EDT 2020

Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells.

International journal of molecular sciences

Natsume C,Aoki N,Aoyama T,Senda K,Matsui M,Ikegami A,Tanaka K,Azuma YT,Fujita T

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Sun Mar 22 00:00:00 EDT 2020

The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis.

Pathogens (Basel, Switzerland)

Heimesaat MM,Genger C,Klove S,Weschka D,Mousavi S,Bereswill S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Tue Sep 29 00:00:00 EDT 2020

Cep55 overexpression promotes genomic instability and tumorigenesis in mice.

Communications biology

Sinha D,Nag P,Nanayakkara D,Duijf PHG,Burgess A,Raninga P,Smits VAJ,Bain AL,Subramanian G,Wall M,Finnie JW,Kalimutho M,Khanna KK

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Wed Oct 21 00:00:00 EDT 2020

Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.

International journal of molecular sciences

Aung KT,Akiyama K,Kunitomo M,Mun AY,Tosa I,Nguyen HTT,Zhang J,Kohno T,Ono M,Hara ES,Kuboki T

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunocytochemistry

Fri Oct 30 00:00:00 EDT 2020

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon Jul 06 00:00:00 EDT 2020

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Tue Apr 16 00:00:00 EDT 2019

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Tue Apr 16 00:00:00 EDT 2019

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.

Immunity

Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Tue Jan 16 00:00:00 EST 2018

Microbial symbionts regulate the primary Ig repertoire.

The Journal of experimental medicine

Chen Y,Chaudhary N,Yang N,Granato A,Turner JA,Howard SL,Devereaux C,Zuo T,Shrestha A,Goel RR,Neuberg D,Wesemann DR

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Mon May 07 00:00:00 EDT 2018

Anti-inflammatory Effects of the Octapeptide NAP in Human Microbiota-Associated Mice Suffering from Subacute Ileitis.

European journal of microbiology & immunology

Escher U,Giladi E,Dunay IR,Bereswill S,Gozes I,Heimesaat MM

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry (Paraffin)

Mon Jun 25 00:00:00 EDT 2018

Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.

Science translational medicine

Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.

The Journal of experimental medicine

Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Mon Apr 03 00:00:00 EDT 2017

Bmp signaling in colonic mesenchyme regulates stromal microenvironment and protects from polyposis initiation.

International journal of cancer

Allaire JM,Roy SA,Ouellet C,Lemieux É,Jones C,Paquet M,Boudreau F,Perreault N

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Wed Jun 01 00:00:00 EDT 2016

Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.

Biochemical and biophysical research communications

Qu X,Li J,Baldwin HS

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Fri Feb 12 00:00:00 EST 2016

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Tue Dec 29 00:00:00 EST 2015

The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.

Immunity & ageing : I & A

Matsuda T,Yanase S,Takaoka A,Maruyama M

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Mon Mar 02 00:00:00 EST 2015

Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.

Carcinogenesis

Dabydeen SA,Kang K,Díaz-Cruz ES,Alamri A,Axelrod ML,Bouker KB,Al-Kharboosh R,Clarke R,Hennighausen L,Furth PA

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Thu Jan 01 00:00:00 EST 2015

Limited miR-17-92 overexpression drives hematologic malignancies.

Leukemia research

Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Sun Mar 01 00:00:00 EST 2015

B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.

PloS one

Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Mon Dec 22 00:00:00 EST 2014

Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria.

The EMBO journal

Panda S,Zhang J,Tan NS,Ho B,Ding JL

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Wed Nov 13 00:00:00 EST 2013

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.

eLife

Olive V,Sabio E,Bennett MJ,De Jong CS,Biton A,McGann JC,Greaney SK,Sodir NM,Zhou AY,Balakrishnan A,Foth M,Luftig MA,Goga A,Speed TP,Xuan Z,Evan GI,Wan Y,Minella AC,He L

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Tue Oct 15 00:00:00 EDT 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Fri Feb 01 00:00:00 EST 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Fri Feb 01 00:00:00 EST 2013

Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.

The Journal of comparative neurology

Gautron L,Rutkowski JM,Burton MD,Wei W,Wan Y,Elmquist JK

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunofluorescence

Fri Nov 01 00:00:00 EDT 2013

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.

Immunity

Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S

Published figure using CD45R (B220) monoclonal antibody (Product # 42-0452-82) in Immunohistochemistry

Fri Feb 25 00:00:00 EST 2011

A role for brain-derived neurotrophic factor in B cell development.

Journal of neuroimmunology

Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA

Wed Jun 01 00:00:00 EDT 2005

Bioinformatics

Protein Aliases: CD45; CD45 antigen; L-CA; Leukocyte common antigen; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen

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Gene Aliases: B220; CD45; CD45R; GP180; L-CA; LCA; loc; Ly-5; LY5; Lyt-4; PTPRC; T200

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UniProt ID: (Human) P08575, (Mouse) P06800

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Entrez Gene ID: (Human) 5788, (Mouse) 19264

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Function(s)

protein tyrosine phosphatase activity transmembrane receptor protein tyrosine phosphatase activity protein binding protein kinase binding phosphoprotein phosphatase activity heparin binding hydrolase activity phosphatase activity heparan sulfate proteoglycan binding protein phosphatase protein modifying enzyme

Process(es)

negative regulation of T cell mediated cytotoxicity negative regulation of cytokine-mediated signaling pathway hematopoietic progenitor cell differentiation immunoglobulin biosynthetic process negative regulation of protein kinase activity protein dephosphorylation negative regulation of cell adhesion involved in substrate-bound cell migration cell surface receptor signaling pathway dephosphorylation T cell differentiation positive regulation of B cell proliferation peptidyl-tyrosine dephosphorylation B cell proliferation positive regulation of T cell proliferation cell cycle phase transition positive regulation of protein kinase activity bone marrow development stem cell development T cell receptor signaling pathway B cell receptor signaling pathway positive regulation of antigen receptor-mediated signaling pathway release of sequestered calcium ion into cytosol defense response to virus regulation of cell cycle positive regulation of hematopoietic stem cell migration positive regulation of stem cell proliferation activation of MAPK activity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response mediated by circulating immunoglobulin leukocyte cell-cell adhesion response to gamma radiation B cell differentiation negative regulation of protein autophosphorylation heterotypic cell-cell adhesion T cell proliferation positive regulation of MAPK cascade positive thymic T cell selection negative thymic T cell selection regulation of B cell differentiation positive regulation of T cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of alpha-beta T cell proliferation positive regulation of isotype switching to IgG isotypes negative regulation of peptidyl-tyrosine phosphorylation regulation of B cell receptor signaling pathway regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway

Performance Guarantee

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CD45R (B220) Monoclonal Antibody (RA3-6B2), eFluor™ 615, eBioscience™

CD45R (B220) Antibody (42-0452-82) in IHC (F)

Product Details

42-0452-82

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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