Product References
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
45-0452-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
45-0452-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
45-0452-82 was used in Flow cytometry/Cell sorting to demonstrate the effects of myeloid cell leukemia 1 (MCL-1) inhibitor on the intramedullary and extramedullary hematopoietic lineages, which is important for the selection of combinations of antitumor drugs and the prevention of adverse hematopoiesis-related effects.
Tue Mar 28 00:00:00 EDT 2023
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Cancer discovery
Chen S,Vedula RS,Cuevas-Navarro A,Lu B,Hogg SJ,Wang E,Benbarche S,Knorr K,Kim WJ,Stanley RF,Cho H,Erickson C,Singer M,Cui D,Tittley S,Durham BH,Pavletich TS,Fiala E,Walsh MF,Inoue D,Monette S,Taylor J,Rosen N,McCormick F,Lindsley RC,Castel P,Abdel-Wahab O
45-0452-82 was used in Flow cytometry/Cell sorting to reveal proteolysis of non-canonical RAS proteins as novel regulators of HSC self-renewal, define the function of RIT1 and LZTR1 mutations in leukemia, and identify means to overcome drug resistance due to LZTR1 downregulation.
Wed Oct 05 00:00:00 EDT 2022
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts.
The Journal of experimental medicine
Kerdidani D,Aerakis E,Verrou KM,Angelidis I,Douka K,Maniou MA,Stamoulis P,Goudevenou K,Prados A,Tzaferis C,Ntafis V,Vamvakaris I,Kaniaris E,Vachlas K,Sepsas E,Koutsopoulos A,Potaris K,Tsoumakidou M
45-0452-82 was used in Flow cytometry/Cell sorting to characterize in the lungs a subset of antigen-presenting fibroblasts with tumor-suppressive properties and propose that cancer immunotherapies might be strongly dependent on in situ MHCII antigen presentation.
Mon Feb 07 00:00:00 EST 2022
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
JCI insight
Zhong L,Yao L,Holdreith N,Yu W,Gui T,Miao Z,Elkaim Y,Li M,Gong Y,Pacifici M,Maity A,Busch TM,Joeng KS,Cengel K,Seale P,Tong W,Qin L
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Aug 19 00:00:00 EDT 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Mar 08 00:00:00 EST 2022
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.
iScience
Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR
45-0452-82 was used in Flow cytometry/Cell sorting to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.
Fri Jul 15 00:00:00 EDT 2022
A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.
Nature communications
Wu J,Yang K,Cai S,Zhang X,Hu L,Lin F,Wu SQ,Xiao C,Liu WH,Han J
45-0452-82 was used in Flow cytometry/Cell sorting to show that plasma cell differentiation and antibody responses are severely impaired in mice with B-cell-specific deletion of p38α, while B-cell development and the germinal centre B-cell response are spared.
Mon Nov 28 00:00:00 EST 2022
Characterization of the spectrum of trivalent VAV1-mutation-driven tumours using a gene-edited mouse model.
Molecular oncology
Robles-Valero J,Fernández-Nevado L,Cuadrado M,Lorenzo-Martín LF,Fernández-Pisonero I,Abad A,Redín E,Montuenga L,Martín-Zanca D,Bigas A,Mallo M,Dosil M,Bustelo XR
45-0452-82 was used in Flow cytometry/Cell sorting to indicate that VAV1 mutations play critical, although highly cell-type-specific, roles in tumourigenesis.
Sat Oct 01 00:00:00 EDT 2022
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Nov 10 00:00:00 EST 2021
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia.
Infection and immunity
Sen-Kilic E,Blackwood CB,Huckaby AB,Horspool AM,Weaver KL,Malkowski AC,Witt WT,Bevere JR,Damron FH,Barbier M
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Jan 19 00:00:00 EST 2021
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem cell research
Sudo K,Yamazaki S,Wilkinson AC,Nakauchi H,Nakamura Y
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
eLife
Hill DL,Whyte CE,Innocentin S,Lee JL,Dooley J,Wang J,James EA,Lee JC,Kwok WW,Zand MS,Liston A,Carr EJ,Linterman MA
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Nov 02 00:00:00 EDT 2021
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
JCI insight
Wilson CS,Stocks BT,Hoopes EM,Rhoads JP,McNew KL,Major AS,Moore DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Oct 08 00:00:00 EDT 2021
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Nature communications
Shang M,Yang H,Yang R,Chen T,Fu Y,Li Y,Fang X,Zhang K,Zhang J,Li H,Cao X,Gu J,Xiao J,Zhang Q,Liu X,Yu Q,Wang T
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.
The Journal of biological chemistry
Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
45-0452 was used in Flow cytometry/Cell sorting to report enhanced toxicity of combined MDM2i and BETi towards AML cell lines, primary human blasts and mouse models, resulting from BETi's ability to evict an unexpected repressive form of BRD4 from p53 target genes, and hence potentiate MDM2i-induced p53 activation.
Mon Jan 11 00:00:00 EST 2021
Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus.
Frontiers in immunology
Jang A,Sharp R,Wang JM,Feng Y,Wang J,Chen M
45-0452-82 was used in flow cytometry to suggest that autophagy is important for the persistence of autoreactive memory B cells, maintenance of autoantibody production, and sustained glomerulonephritis in pristane-induced lupus.
Fri Dec 10 00:00:00 EST 2021
Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition.
Cell reports
Stephens WZ,Kubinak JL,Ghazaryan A,Bauer KM,Bell R,Buhrke K,Chiaro TR,Weis AM,Tang WW,Monts JK,Soto R,Ekiz HA,O'Connell RM,Round JL
45-0452-82 was used in Flow cytometry/Cell sorting to demonstrate a role for IEC-derived MHC class II in constraining microbiota composition and inducing tolerogenic responses against it.
Tue Nov 02 00:00:00 EDT 2021
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Immunity
Lederer K,Castaño D,Gómez Atria D,Oguin TH,Wang S,Manzoni TB,Muramatsu H,Hogan MJ,Amanat F,Cherubin P,Lundgreen KA,Tam YK,Fan SHY,Eisenlohr LC,Maillard I,Weissman D,Bates P,Krammer F,Sempowski GD,Pardi N,Locci M
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Proceedings of the National Academy of Sciences of the United States of America
Tian M,McGovern K,Cheng HL,Waddicor P,Rieble L,Dao M,Chen Y,Kimble MT,Cantor E,Manfredonia N,Judson R,Chapdelaine-Williams A,Cain DW,Haynes BF,Alt FW
45-0452 was used in Flow cytometry/Cell sorting to develop a new approach to test a vaccine which circumvents B cell developmental blocks.
Tue Apr 07 00:00:00 EDT 2020
Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
PLoS biology
Xiao J,Wang C,Yao JC,Alippe Y,Yang T,Kress D,Sun K,Kostecki KL,Monahan JB,Veis DJ,Abu-Amer Y,Link DC,Mbalaviele G
45-0452 was used in Flow cytometry/Cell sorting to test the hypothesis that lethal radiation damages tissues, thereby unleashing signals that indiscriminately activate the inflammasome pathways in host and transplanted cells.
Sat Aug 01 00:00:00 EDT 2020
Protein tyrosine phosphatase 1B is involved in efficient type I interferon secretion upon viral infection.
Journal of cell science
Reimer E,Stempel M,Chan B,Bley H,Brinkmann MM
45-0452 was used in Flow cytometry/Cell sorting to provide evidence for a novel function of PTP1B that is independent of its phosphatase activity, but requires its localisation to the membrane of the endoplasmic reticulum.
Thu Apr 23 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Frontiers in immunology
Larson SR,Bortell N,Illies A,Crisler WJ,Matsuda JL,Lenz LL
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
45-0452 was used in Flow cytometry/Cell sorting to suggest that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.
Mon Jun 14 00:00:00 EDT 2021
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
45-0452 was used in Flow cytometry/Cell sorting to suggest that targeting Shp1 may be an attractive therapeutic strategy for boosting the immune response to cancer via a mechanism involving both innate and adaptive leukocytes.
Mon Jun 14 00:00:00 EDT 2021
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
45-0452 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.
Frontiers in pharmacology
Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y
45-0452-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.
Tue Feb 16 00:00:00 EST 2021
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding.
Cell stem cell
Pei W,Shang F,Wang X,Fanti AK,Greco A,Busch K,Klapproth K,Zhang Q,Quedenau C,Sauer S,Feyerabend TB,Höfer T,Rodewald HR
45-0452 was used in Flow cytometry/Cell sorting to develop the PolyloxExpress allele, enabling Cre-recombinase-dependent RNA barcoding in situ.
Thu Sep 03 00:00:00 EDT 2020
Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis.
Cell reports
Ko JH,Kim HJ,Jeong HJ,Lee HJ,Oh JY
45-0452-82 was used in Flow Cytometry to demonstrate the role of mesenchymal stem and stromal cell and macrophage cross-talk in post-injury tissue homeostasis in mice.
Tue Mar 17 00:00:00 EDT 2020
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
45-0452 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Post-transplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression.
The Journal of clinical investigation
Wachsmuth LP,Patterson MT,Eckhaus MA,Venzon DJ,Gress RE,Kanakry CG
45-0452-82 was used in Flow Cytometry to prompt a paradigm-shift in our mechanistic understanding of PTCy.
Tue Mar 26 00:00:00 EDT 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue May 14 00:00:00 EDT 2019
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.
Cell reports
Adane B,Ye H,Khan N,Pei S,Minhajuddin M,Stevens BM,Jones CL,D'Alessandro A,Reisz JA,Zaberezhnyy V,Gasparetto M,Ho TC,Kelly KK,Myers JR,Ashton JM,Siegenthaler J,Kume T,Campbell EL,Pollyea DA,Becker MW,Jordan CT
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Apr 02 00:00:00 EDT 2019
Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses.
Cell reports
Cousin C,Oberkampf M,Felix T,Rosenbaum P,Weil R,Fabrega S,Morante V,Negri D,Cara A,Dadaglio G,Leclerc C
45-0452 was used in Flow cytometry/Cell sorting to demonstrate that integrase-deficient lentiviral vectors can trigger persistent adaptive response by the mediation of a weak and transient innate response alongside the persistence of the vector in tissues.
Tue Jan 29 00:00:00 EST 2019
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Frontiers in immunology
Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ
45-0452-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.
Tue Oct 13 00:00:00 EDT 2020
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Mar 15 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Incorporation of CD40 ligand enhances the immunogenicity of tumor‑associated calcium signal transducer 2 virus‑like particles against lung cancer.
International journal of molecular medicine
Xi W,Ke D,Min L,Lin W,Jiahui Z,Fang L,Zhaowei G,Zhe Z,Xi C,Huizhong Z
45-0452 was used in Flow cytometry/Cell sorting to provide a novel vaccine design by combination of a tumor antigen and an immune adjuvant based on a VLP strategy, which may be potentially applied as an alternative immunotherapeutic option in the treatment of lung cancer.
Fri Jun 01 00:00:00 EDT 2018
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Experimental and therapeutic medicine
Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.
Frontiers in immunology
Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Sep 26 00:00:00 EDT 2019
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
45-0452 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.
Mon Jul 16 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
45-0452 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
45-0452 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
45-0452 was used in Flow cytometry/Cell sorting to report that the GEF Vav1 unexpectedly possesses tumor-suppressor functions in immature T cells.
Mon Nov 13 00:00:00 EST 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.
Mucosal immunology
Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL
45-0452 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.
Mon May 01 00:00:00 EDT 2017
Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.
Journal of immunology (Baltimore, Md. : 1950)
Cecchinato V,Bernasconi E,Speck RF,Proietti M,Sauermann U,D'Agostino G,Danelon G,Rezzonico Jost T,Grassi F,Raeli L,Schöni-Affolter F,Stahl-Hennig C,Uguccioni M
45-0452 was used in Flow cytometry/Cell sorting to investigate how actin polymerization modulation restores lymphocyte migration in response to chemokines in HIV-1 infection.
Sun Jan 01 00:00:00 EST 2017
Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Wiesner DL,Smith KD,Kashem SW,Bohjanen PR,Nielsen K
45-0452 was used in Flow cytometry/Cell sorting to study the lymphocyte subsets responsible for the oesinophil or neutrophil response to infection with Cryptococcus neoformans.
Wed Feb 15 00:00:00 EST 2017
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2017
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nature communications
Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
JCI insight
Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
PloS one
Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors.
Cell reports
Boulianne B,Robinson ME,May PC,Castellano L,Blighe K,Thomas J,Reid A,Müschen M,Apperley JF,Stebbing J,Feldhahn N
45-0452 was used in Flow cytometry/Cell sorting to demonstrate lineage-specific transcription predisposes genes in B cells to DNA damage.
Tue Feb 14 00:00:00 EST 2017
Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.
Scientific reports
Tsiantoulas D,Kiss M,Bartolini-Gritti B,Bergthaler A,Mallat Z,Jumaa H,Binder CJ
45-0452 was used in Flow cytometry/Cell sorting to identify secreted IgM as negative regulators of BCR signalling and suggest that they can act as decoy receptors for self-antigens that are recognised by membrane bound BCRs.
Wed Jun 14 00:00:00 EDT 2017
RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma.
eLife
Arikkatt J,Ullah MA,Short KR,Zhang V,Gan WJ,Loh Z,Werder RB,Simpson J,Sly PD,Mazzone SB,Spann KM,Ferreira MA,Upham JW,Sukkar MB,Phipps S
45-0452 was used in Flow cytometry/Cell sorting to show that RAGE deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice.
Wed Jan 18 00:00:00 EST 2017
Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.
Journal of hepatology
Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ
45-0452 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.
Fri Jan 01 00:00:00 EST 2016
Potential of PEGylated Toll-Like Receptor 7 Ligands for Controlling Inflammation and Functional Changes in Mouse Models of Asthma and Silicosis.
Frontiers in immunology
Ferreira TP,Mariano LL,Ghilosso-Bortolini R,de Arantes AC,Fernandes AJ,Berni M,Cecchinato V,Uguccioni M,Maj R,Barberis A,Silva PM,Martins MA
45-0452 was used in Flow cytometry/Cell sorting to evaluate the therapeutic potential of two PEGylated purine-like compounds characterised by TLR7 partial agonistic activity.
Fri Mar 25 00:00:00 EDT 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
45-0452 was used in Flow cytometry/Cell sorting to identify a novel pathway of cross-talk between macrophages and dendritic cells.
Sat Oct 01 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice.
Infection and immunity
Roffê E,Marino APMP,Weaver J,Wan W,de Araújo FF,Hoffman V,Santiago HC,Murphy PM
45-0452 was used in Flow cytometry/Cell sorting to investigate T. cruzi infection as a trigger of vasculitis.
Fri Apr 01 00:00:00 EDT 2016
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes.
Biology open
Morris JL,Bridson TL,Alim MA,Rush CM,Rudd DM,Govan BL,Ketheesan N
45-0452 was used in Flow cytometry/Cell sorting to develop a novel murine model, based on an energy-dense diet, which closely simulates the development of type 2 diabetes.
Mon Aug 15 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
PloS one
Vicetti Miguel RD,Quispe Calla NE,Pavelko SD,Cherpes TL
45-0452 was used in Flow cytometry/Cell sorting to determine if intravaginal infection with occulogenital Chlamydia trachomatis is a possible mouse model for Chlamydia infection in humans.
Fri Aug 04 00:00:00 EDT 2017
Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation.
Scientific reports
Huang M,Zhang W,Guo J,Wei X,Phiwpan K,Zhang J,Zhou X
45-0452 was used in Flow cytometry/Cell sorting to develop a new transgenic mice model to study the expression and antigen presentation of HLA-I molecules.
Fri Sep 16 00:00:00 EDT 2016
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.
Nature communications
Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X
45-0452 was used in Flow cytometry/Cell sorting to explore a role of REGγ in the regulation of NFκB and the effect of this on the development of bowel inflammation and associated tumour formation.
Mon Feb 22 00:00:00 EST 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
45-0452-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Nature communications
Spanier JA,Frederick DR,Taylor JJ,Heffernan JR,Kotov DI,Martinov T,Osum KC,Ruggiero JL,Rust BJ,Landry SJ,Jenkins MK,McLachlan JB,Fife BT
45-0452 was used in Flow cytometry/Cell sorting to develop a novel approach for the generation and screening of peptide:MHCII reactive mAbs that exploits the use of recombinant peptide:MHC monomers as immunogens.
Mon Jun 13 00:00:00 EDT 2016
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
eLife
Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F
45-0452 was used in Flow cytometry/Cell sorting to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.
Mon Jan 18 00:00:00 EST 2016
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Nature immunology
Schliehe C,Flynn EK,Vilagos B,Richson U,Swaminanthan S,Bosnjak B,Bauer L,Kandasamy RK,Griesshammer IM,Kosack L,Schmitz F,Litvak V,Sissons J,Lercher A,Bhattacharya A,Khamina K,Trivett AL,Tessarollo L,Mesteri I,Hladik A,Merkler D,Kubicek S,Knapp S,Epstein MM,Symer DE,Aderem A,Bergthaler A
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of Setdb2 in regulation of immune responses during bacterial infection.
Thu Jan 01 00:00:00 EST 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis.
European journal of immunology
Frykman PK,Cheng Z,Wang X,Dhall D
45-0452 was used in Flow cytometry/Cell sorting to investigate how enterocolitis in the Ednrb(-/-) and Edn3(-/-) mice lead to thymic involution, splenic lymphopenia, and suppression of B lymphopoiesis as a consequence of colonic aganglionosis.
Sun Mar 01 00:00:00 EST 2015
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of the Interleukin-1 receptor type 2 (IL-1R2) as a regulator of arthritis, by acting specifically on macrophages as a decoy receptor for IL-1.
Wed Apr 01 00:00:00 EDT 2015
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
Journal of immunology (Baltimore, Md. : 1950)
Cabrera-Perez J,Condotta SA,James BR,Kashem SW,Brincks EL,Rai D,Kucaba TA,Badovinac VP,Griffith TS
45-0452 was used in Flow cytometry/Cell sorting to demonstrate that the recovery of CD4 T cells from sepsis-induced lymphopenia is accompanied by alterations to the composition and function of the Ag-specific CD4 T cell repertoire.
Sun Feb 15 00:00:00 EST 2015
Non-CpG Oligonucleotides Exert Adjuvant Effects by Enhancing Cognate B Cell-T Cell Interactions, Leading to B Cell Activation, Differentiation, and Isotype Switching.
Journal of immunology research
Herbáth M,Papp K,Erdei A,Prechl J
45-0452 was used in Flow cytometry/Cell sorting to propose that non-CpG ODN may perform as better adjuvants when a strong antigen-independent immune activation, elicited by CpG ODNs, is undesirable.
Tue May 24 00:00:00 EDT 2016
The omentum is a site of protective IgM production during intracellular bacterial infection.
Infection and immunity
Jones DD,Racine R,Wittmer ST,Harston L,Papillion AM,Dishaw LM,Randall TD,Woodland DL,Winslow GM
45-0452 was used in Flow cytometry/Cell sorting to identify the omentum as an important auxiliary site of IgM production during intracellular bacterial infection.
Fri May 01 00:00:00 EDT 2015
Endothelial Gata5 transcription factor regulates blood pressure.
Nature communications
Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M
45-0452 was used in Flow cytometry/Cell sorting to study the aetiology of human hypertension, showing that GATA5, an endothelial transcription factor, regulates blood pressure, allowing the development of a new animal model of hypertension for further studies.
Mon Nov 30 00:00:00 EST 2015
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.
Nature communications
Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Jun 24 00:00:00 EDT 2015
A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo.
PloS one
Phiwpan K,Guo J,Zhang W,Hu T,Boruah BM,Zhang J,Zhou X
45-0452 was used in Flow cytometry/Cell sorting to demonstrate a novel approach for detecting miR expression in specific cell types of interest.
Tue Apr 12 00:00:00 EDT 2016
Immature B Cell Egress from Bone Marrow Is SOCS3 Independent.
PloS one
Nadrah K,Beck TC,Pereira JP
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of suppressor of cytokine signaling 3 (SOCS3) in mediating immature B cell egress from the bone marrow, and other biological processes controlled by CXCR4 signalling.
Fri May 06 00:00:00 EDT 2016
Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells.
PloS one
Zhang J,Li L,Baldwin AS,Friedman AD,Paz-Priel I
45-0452 was used in Flow cytometry/Cell sorting to study the effects of IKKβ and NF-κB p65 on hematopoietic lineage commitment and progenitor self-renewal and functional long-term hematopoietic stem cells.
Wed Apr 13 00:00:00 EDT 2016
Essential role for autophagy in the maintenance of immunological memory against influenza infection.
Nature medicine
Chen M,Hong MJ,Sun H,Wang L,Shi X,Gilbert BE,Corry DB,Kheradmand F,Wang J
45-0452 was used in Flow cytometry/Cell sorting to demonstrate autophagy is essential for the survival of virus-specific memory B cells and maintenance of protective antibody responses.
Thu May 01 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
45-0452 was used in Flow cytometry/Cell sorting to study regulation of the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis during autophagy.
Tue Jul 01 00:00:00 EDT 2014
Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Shinoda K,Akiyoshi T,Chase CM,Farkash EA,Ndishabandi DK,Raczek CM,Sebastian DP,Pelle PD,Russell PS,Madsen JC,Colvin RB,Alessandrini A
45-0452 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to investigate the relative contribution of central and peripheral mechanisms to the generation of skin and heart allograft tolerance in murine mixed chimeras.
Wed Oct 01 00:00:00 EDT 2014
The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.
Journal of leukocyte biology
Guo H,Ma O,Friedman AD
45-0452 was used in Flow cytometry/Cell sorting to assess the selectiveness of the C/EBPα enhancer to regulate gene expression in particular cell types.
Mon Sep 01 00:00:00 EDT 2014
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Journal of immunology (Baltimore, Md. : 1950)
Park KS,Bayles I,Szlachta-McGinn A,Paul J,Boiko J,Santos P,Liu J,Wang Z,Borghesi L,Milcarek C
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Sat Nov 01 00:00:00 EDT 2014
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Journal of immunology (Baltimore, Md. : 1950)
Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Apr 01 00:00:00 EDT 2014
Generation of a novel Cr2 gene allele by homologous recombination that abrogates production of Cr2 but is sufficient for expression of Cr1.
Immunobiology
Donius LR,Orlando CM,Weis JJ,Weis JH
45-0452 was used in Flow cytometry/Cell sorting to study how the Cr2KO mouse provides a new model system for the analysis of Cr1 and Cr2 functions in the immune response of the mouse.
Wed Jan 01 00:00:00 EST 2014
Rhof promotes murine marginal zone B cell development.
Nagoya journal of medical science
Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Aug 01 00:00:00 EDT 2014
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
PloS one
Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route.
PloS one
Pisano F,Heine W,Rosenheinrich M,Schweer J,Nuss AM,Dersch P
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of PhoP in oral infections, showing that virulence of Yersinia pseudotuberculosis is influenced by PhoP and intra-species variations.
Thu Nov 12 00:00:00 EST 2015
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
eLife
Kläsener K,Maity PC,Hobeika E,Yang J,Reth M
45-0452 was used in Flow cytometry/Cell sorting to provide direct evidence for the opening of B cell antigen receptor dimers during B cell activation.
Tue Jun 24 00:00:00 EDT 2014
Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.
PloS one
Nagano T,Edamatsu H,Kobayashi K,Takenaka N,Yamamoto M,Sasaki N,Nishimura Y,Kataoka T
45-0452 was used in Flow cytometry/Cell sorting to demonstrate that PLCε is important in bronchial asthma pathogenesis through upregulating inflammatory cytokine production by bronchial epithelial cells.
Wed Jun 10 00:00:00 EDT 2015
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
45-0452 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.
European journal of immunology
Todd EM,Deady LE,Morley SC
45-0452 was used in Flow cytometry/Cell sorting to study the role of L-plastin in the modulation of both T- and B-cell immune responses.
Mon Jul 01 00:00:00 EDT 2013
Sox4 is required for the survival of pro-B cells.
Journal of immunology (Baltimore, Md. : 1950)
Sun B,Mallampati S,Gong Y,Wang D,Lefebvre V,Sun X
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of Sox4 in development of mature B cells, showing that it is required for pro-B cell survival.
Fri Mar 01 00:00:00 EST 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
45-0452 was used in Flow cytometry/Cell sorting to identify a unique function for gV-sPLA2 in the activation and recruitment of immune cells.
Sat Jun 15 00:00:00 EDT 2013
B cell activating factor inhibition impairs bacterial immunity by reducing T cell-independent IgM secretion.
Infection and immunity
Jones DD,Jones M,DeIulio GA,Racine R,MacNamara KC,Winslow GM
45-0452 was used in Flow cytometry/Cell sorting to determine that BAFF signalling can directly regulate secretory processes.
Sun Dec 01 00:00:00 EST 2013
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu Jun 13 00:00:00 EDT 2013
Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.
European journal of immunology
Dahlem T,Cho S,Spangrude GJ,Weis JJ,Weis JH
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional repressor Snai3 protein in the derivation of cells of the haematopoietic system.
Sun Apr 01 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.
PloS one
Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M
45-0452 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.
Tue Jun 11 00:00:00 EDT 2013
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
45-0452 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.
Nature immunology
Yang CY,Best JA,Knell J,Yang E,Sheridan AD,Jesionek AK,Li HS,Rivera RR,Lind KC,D'Cruz LM,Watowich SS,Murre C,Goldrath AW
45-0452 was used in Flow cytometry/Cell sorting to elucidate the mechanisms of regulation of terminal differentiation of CD8(+) T cells.
Sun Nov 06 00:00:00 EDT 2011
The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Giannattasio G,Ohta S,Boyce JR,Xing W,Balestrieri B,Boyce JA
45-0452 was used in Flow cytometry/Cell sorting to reveal the role of P2Y(6) receptors for protecting the lung against exuberant allergen-induced pulmonary inflammation.
Mon Aug 01 00:00:00 EDT 2011
The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Todd EM,Deady LE,Morley SC
45-0452 was used in Flow cytometry/Cell sorting to study the role of the actin-bundling protein L-plastin in B cell chemotaxis.
Thu Sep 15 00:00:00 EDT 2011
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.
PloS one
Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2011
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
45-0452 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
Immature and transitional B cells are latency reservoirs for a gammaherpesvirus.
Journal of virology
Coleman CB,Nealy MS,Tibbetts SA
45-0452 was used in Flow cytometry/Cell sorting to examine whether murine gammaherpesvirus 68 establishes latency in developing B cells during a normal course of infection.
Wed Dec 01 00:00:00 EST 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
45-0452 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
PloS one
Cheng N,van de Wetering CI,Knudson CM
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Apr 02 00:00:00 EDT 2008
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
45-0452 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 EST 2007
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2007
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Molecular and cellular biology
Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2006
A role for brain-derived neurotrophic factor in B cell development.
Journal of neuroimmunology
Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA
Wed Jun 01 00:00:00 EDT 2005
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
Molecular and cellular biology
Pan L,Sato S,Frederick JP,Sun XH,Zhuang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 45-0452-82) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 1999
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-RA3-6B2-RE-AV-20170920122035.jpg?time=20240507?time=20240507 "CD45R (B220) Antibody (45-0452-82)")
