Product References
Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals.
Oncology research
Wu X,Guan S,Lu Y,Xue J,Yu X,Zhang QI,Wang X,Li T
11-4801-82 was used in Flow cytometry/Cell sorting to conclude that the conditional knockout of SHP-2 can activate the Ang/Tie2-PI3K/Akt/mTOR pathway in TEMs, thereby strengthening tumor micro angiogenesis in the microenvironment and facilitating CRC liver metastasis.
Wed Jun 21 00:00:00 EDT 2023
Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model.
Pharmaceutics
D'Urso A,Oltolina F,Borsotti C,Prat M,Colangelo D,Follenzi A
11-4801-82 was used in Flow cytometry/Cell sorting to provide a novel strategy for the development of new tumor immunotherapies in vivo.
Mon Jun 12 00:00:00 EDT 2023
GPAT3 regulates the synthesis of lipid intermediate LPA and exacerbates Kupffer cell inflammation mediated by the ERK signaling pathway.
Cell death & disease
Fan G,Li Y,Zong Y,Suo X,Jia Y,Gao M,Yang X
11-4801-82 was used in Immunohistochemistry (PFA fixed) to report that glycerol-3-phosphate acyltransferase 3 (GPAT3) plays a key role in Kupffer cells (KCs) inflammation response.
Fri Mar 24 00:00:00 EDT 2023
Dehydration Accelerates Cytogenesis and Cyst Growth in Pkd1-/- Mice by Regulating Macrophage M2 Polarization.
Inflammation
Yang Y,Zhou J,Zhang D,Lv J,Chen M,Wang C,Song M,He F,Song S,Mei C
11-4801-82 was used in Immunohistochemistry to examine whether dehydration, as a common kidney risk factor, could cause cystogenesis in chronic-onset Pkd1-/- mice by regulating macrophage activation.
Tue Aug 01 00:00:00 EDT 2023
Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.
Materials today. Bio
Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L
11-4801-82 was used in Flow cytometry/Cell sorting to develop an oxygen-carrying nanoplatform loaded with perfluorooctyl bromide (PFOB, a second-generation of perfluorocarbon-based blood substitute), IR780 (a photosensitizer) and imiquimod (R837, an immune adjuvant) to reprogram immunosuppressive TME and reinforce photothermal-immunotherapy.
Sat Apr 01 00:00:00 EDT 2023
Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils.
British journal of cancer
Jacenik D,Karagiannidis I,Beswick EJ
11-4801-82 was used in Immunohistochemistry (PFA fixed) to demonstrate the significance of Th2 cells, eosinophils and IL-5 in the inhibition of gastrointestinal tumor growth, and pointed toward tumor microenvironment reprogramming as a Th2 cell-mediated anti-tumorigenic mechanism of action.
Sun Jan 01 00:00:00 EST 2023
Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment.
International journal of biological sciences
Qin H,Luo Z,Sun Y,He Z,Qi B,Chen Y,Wang J,Li C,Lin W,Han Z,Zhu Y
11-4801-82 was used in Flow cytometry/Cell sorting to conclude that the ability of low-intensity pulsed ultrasound (LIPUS) to direct macrophage polarization may be a beneficial target in the clinical treatment of many injuries and inflammatory diseases.
Mon Mar 20 00:00:00 EDT 2023
Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.
Experimental & molecular medicine
Seo SH,Kim E,Yoon M,Lee SH,Park BH,Choi KY
11-4801-82 was used in Enzyme-linked immunosorbent assay to conclude that the pronounced metabolic improvements with the stimulation of liver regeneration by interfering with the CXXC5-Dvl interaction provide a therapeutic approach for NASH.
Thu Sep 01 00:00:00 EDT 2022
Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.
Nature communications
Dai B,Xu J,Li X,Huang L,Hopkins C,Wang H,Yao H,Mi J,Zheng L,Wang J,Tong W,Chow DH,Li Y,He X,Hu P,Chen Z,Zu H,Li Y,Yao Y,Jiang Q,Qin L
11-4801-82 was used in Immunohistochemistry to show that epididymal white adipose tissue-secreted osteopontin induces lipophagocytic mobilization of bone marrow-derived macrophages (BMDMs) to a lipid-rich pool in the bone marrow, promotes bone matrix degradation by activating osteoclasts in high-fat diet-fed mice, and blocks both lipolysis and osteoclastogenesis in BMDMs by limiting the energy regeneration by ATP6V0d2 in lysosomes.
Thu Jan 20 00:00:00 EST 2022
Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages.
Chinese medical journal
Liu X,Jiang Q,Shen S,Hou Y
11-4801-82 was used in Flow cytometry/Cell sorting to suggest that the different outcomes of tumor growth might be attributed to the infiltration of anti-tumor or pro-tumor immune cells, especially M1 or M2 type macrophages into tumor microenvironment.
Fri Aug 05 00:00:00 EDT 2022
Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations.
Cell reports
Leinroth AP,Mirando AJ,Rouse D,Kobayahsi Y,Tata PR,Rueckert HE,Liao Y,Long JT,Chakkalakal JV,Hilton MJ
11-4801-82 was used in Flow cytometry/Cell sorting to identify six distinct Pdgfra+ non-myogenic muscle-resident mesenchymal cell populations that fit within a bipartite differentiation trajectory from a common progenitor.
Tue May 10 00:00:00 EDT 2022
Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages.
Scientific reports
Gulay KCM,Aoshima K,Maekawa N,Suzuki T,Konnai S,Kobayashi A,Kimura T
11-4801-82 was used in Flow Cytometry to valuated two mouse Hemangiosarcoma (HSA) cell lines and one immortalized mouse endothelial cell line for their usefulness as syngeneic models for canine HSA.
Tue Feb 08 00:00:00 EST 2022
Role of circular RNA cdr1as in modulation of macrophage phenotype.
Life sciences
Gonzalez C,Cimini M,Cheng Z,Benedict C,Wang C,Trungcao M,Mallaredy V,Rajan S,Garikipati VNS,Kishore R
11-4801-82 was used in Flow Cytometry to suggest that circ-Cdr1as plays a key role in regulating anti-inflammatory phenotype of macrophages and may potentially be developed as an anti-inflammatory regulator in tissue inflammation.
Tue Nov 15 00:00:00 EST 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
11-4801-82 was used in Flow Cytometry to investigate TβRII and extracellular vesicle delivery in breast cancer to derive targets for immunotherapy.
Mon Aug 01 00:00:00 EDT 2022
Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis.
Developmental cell
Wang W,Prokopec JS,Zhang Y,Sukhoplyasova M,Shinglot H,Wang MT,Linkermann A,Stewart-Ornstein J,Gong YN
11-4801-82 was used in Flow cytometry/Cell sorting to find that cells which undergo limited plasma membrane damage from the pore-forming actions of MLKL, GSDMD, perforin, or detergents experience local activation of PKCs through Ca2+ influx at the damage sites.
Mon Jan 24 00:00:00 EST 2022
STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao Y,Ma C,Chen C,Li S,Wang Y,Yang T,Stetler RA,Bennett MVL,Dixon CE,Chen J,Shi Y
11-4801-82 was used in Flow cytometry/Cell sorting to show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain injury using a mouse model, presenting STAT1 as a promising therapeutic target for TBI.
Wed Sep 28 00:00:00 EDT 2022
Cytosolic Nuclear Sensor Dhx9 Controls Medullary Thymic Epithelial Cell Differentiation by p53-Mediated Pathways.
Frontiers in immunology
Dong X,Zhang J,Zhang Q,Liang Z,Xu Y,Zhao Y,Zhang B
11-4801-82 was used in Flow cytometry/Cell sorting to reveal that Dhx9, a cytosolic nuclear sensor recognizes viral DNA or RNA, playing an important role in mTEC development and function in mice.
Tue Jun 21 00:00:00 EDT 2022
Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.
PLoS pathogens
Demars A,Vitali A,Comein A,Carlier E,Azouz A,Goriely S,Smout J,Flamand V,Van Gysel M,Wouters J,Abendroth J,Edwards TE,Machelart A,Hoffmann E,Brodin P,De Bolle X,Muraille E
11-4801-82 was used in Flow Cytometry to identify the effector mechanisms controlling the early stages of intranasal infection with Brucella in mice.
Wed Sep 01 00:00:00 EDT 2021
TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization.
Oxidative medicine and cellular longevity
Luo Y,Guo J,Jia W,Wu M,Yin F,Niu G,Shih DQ,Targan SR,Zhang X
11-4801-82 was used in Flow cytometry/Cell sorting to investigate the role of TNF-like ligand 1 aberrance (TL1A) in nonalcoholic steatohepatitis (NASH).
Fri Mar 04 00:00:00 EST 2022
Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.
The Journal of reproduction and development
Hirata Y,Katsukura Y,Henmi Y,Ozawa R,Shimazaki S,Kurosawa A,Torii Y,Takahashi H,Iwata H,Kuwayama T,Shirasuna K
11-4801-82 was used in Flow cytometry/Cell sorting to suggest that general cellular senescence programs may not be included in the placenta and that placental functions, including SASP production and immune cell accumulation, gradually decrease in a maternal age-dependent manner, resulting in a higher rate of pregnancy complications.
Fri Aug 27 00:00:00 EDT 2021
Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.
Stem cell research & therapy
Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q
11-4801 was used in Flow cytometry/Cell sorting to indicate that ADM2 enhances diabetic bone regeneration during DO, by attenuating AGE-induced imbalances in macrophage polarization, partly through PPARγ/NF-κB signaling, and improving AGE-impaired osteogenic differentiation of BMSCs simultaneously.
Thu May 13 00:00:00 EDT 2021
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways.
Cell death discovery
Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ
11-4801-82 was used in Flow Cytometry to provide insights into the functional role of bone marrow-derived sesenchymal stem cell in alleviating liver fibrosis.
Mon Sep 13 00:00:00 EDT 2021
Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with GMCSF+IFN α Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model.
Biomedicines
Tham SM,Rahmat JN,Chiong E,Wu Q,Esuvaranathan K,Mahendran R
11-4801-82 was used in Flow cytometry/Cell sorting to evaluate a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains.
Thu Nov 25 00:00:00 EST 2021
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
11-4801-82 was used in Flow Cytometry to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 EST 2021
CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype.
Journal of translational medicine
Ma J,Hu W,Zhang D,Xie J,Duan C,Liu Y,Wang Y,Xu X,Cheng K,Jin B,Zhang Y,Zhuang R
11-4801-82 was used in Immunocytochemistry to show that the costimulatory molecule CD226 was highly expressed on adipose tissue macrophages and knockout of CD226 alleviated obesity caused by high-fat diet.
Thu Nov 25 00:00:00 EST 2021
Rapid proliferation due to better metabolic adaptation results in full virulence of a filament-deficient Candida albicans strain.
Nature communications
Dunker C,Polke M,Schulze-Richter B,Schubert K,Rudolphi S,Gressler AE,Pawlik T,Prada Salcedo JP,Niemiec MJ,Slesiona-Künzel S,Swidergall M,Martin R,Dandekar T,Jacobsen ID
11-4801-82 was used in Flow Cytometry to challenge the long-standing hypothesis that hyphae are essential for pathogenesis of systemic candidiasis by C. albicans.
Wed Jun 23 00:00:00 EDT 2021
Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype.
International journal of medical sciences
Liu X,Xu Y,Li Y,Pan Y,Zhao S,Hou Y
11-4801-82 was used in Flow cytometry/Cell sorting to create a nanocomposite of Ferumoxytol (FMT) surface-coated with β-glucan (FMT-β-glucan), which effectively suppressed melanoma growth by promoting the polarization of M1 macrophages in the tumor microenvironment, enhancing the antitumor effect both in vivo and in vitro, likely through the upregulation of Dectin-1 and activation of MAPK and NF-κB signaling pathways in macrophages.
Mon Jan 10 00:00:00 EST 2022
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
11-4801-82 was used in Flow Cytometry to profile cellular transcriptomes of lung tumours at different stages.
Mon Aug 10 00:00:00 EDT 2020
The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
The Journal of experimental medicine
Kang L,Zhang X,Ji L,Kou T,Smith SM,Zhao B,Guo X,Pineda-Torra I,Wu L,Hu X
11-4801-82 was used in Flow Cytometry to demonstrate that colonic macrophage-intrinsic RBP-J dynamically orchestrates intestinal immunity against pathogen infections by interfacing with key immune cells of T and innate lymphoid cell lineages.
Mon Apr 06 00:00:00 EDT 2020
Peripherally derived angiotensin converting enzyme-enhanced macrophages alleviate Alzheimer-related disease.
Brain : a journal of neurology
Koronyo-Hamaoui M,Sheyn J,Hayden EY,Li S,Fuchs DT,Regis GC,Lopes DHJ,Black KL,Bernstein KE,Teplow DB,Fuchs S,Koronyo Y,Rentsendorj A
11-4801 was used in Flow cytometry/Cell sorting to explore the impact of selective and transient angiotensin-converting enzyme overexpression on macrophage behaviour and the relative contribution of bone marrow-derived ACE10 macrophages, but not microglia, in attenuating disease progression.
Wed Jan 01 00:00:00 EST 2020
Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition.
Proceedings of the National Academy of Sciences of the United States of America
Tang PM,Zhang YY,Xiao J,Tang PC,Chung JY,Li J,Xue VW,Huang XR,Chong CC,Ng CF,Lee TL,To KF,Nikolic-Paterson DJ,Lan HY
11-4801-81 was used in Immunocytochemistry, Flow Cytometry to establish a role for Pou4f1 in MMT and renal fibrosis and suggest that Pou4f1 may be a therapeutic target for chronic kidney disease with progressive renal fibrosis.
Tue Aug 25 00:00:00 EDT 2020
Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage-myofibroblast transition.
Proceedings of the National Academy of Sciences of the United States of America
Tang PM,Zhang YY,Xiao J,Tang PC,Chung JY,Li J,Xue VW,Huang XR,Chong CC,Ng CF,Lee TL,To KF,Nikolic-Paterson DJ,Lan HY
11-4801-81 was used in Immunocytochemistry, Flow Cytometry to establish a role for Pou4f1 in MMT and renal fibrosis and suggest that Pou4f1 may be a therapeutic target for chronic kidney disease with progressive renal fibrosis.
Tue Aug 25 00:00:00 EDT 2020
Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury.
Mucosal immunology
Wang C,Li Q,Lv J,Sun X,Cao Y,Yu K,Miao C,Zhang ZS,Yao Z,Wang Q
11-4801 was used in Flow cytometry/Cell sorting to study the role of GM-CSF in HlyA-mediated kidney injury.
Wed Jan 01 00:00:00 EST 2020
Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.
Mucosal immunology
Ge Y,Gong M,Zadeh M,Li J,Abbott JR,Li W,Morel L,Sonon R,Supekar NT,Azadi P,Wang Y,Jones DP,Li S,Mohamadzadeh M
11-4801 was used in Flow cytometry/Cell sorting to study the molecular mechanisms responsible for regulating gut homeostasis.
Wed Jan 01 00:00:00 EST 2020
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
The Journal of investigative dermatology
Weitzmann A,Naumann R,Dudeck A,Zerjatke T,Gerbaulet A,Roers A
11-4801 was used in Flow cytometry/Cell sorting to conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories.
Tue Dec 01 00:00:00 EST 2020
Pre-existing antibody-mediated adverse effects prevent the clinical development of a bacterial anti-inflammatory protein.
Disease models & mechanisms
Tromp AT,Zhao Y,Jongerius I,Heezius ECJM,Abrial P,Ruyken M,van Strijp JAG,de Haas CJC,Spaan AN,van Kessel KPM,Henry T,Haas PA
11-4801 was used in Flow cytometry/Cell sorting to show that the administration of CHIPS in human C5AR1 knock-in mice successfully dampens C5a-mediated neutrophil migration during immune complex-initiated inflammation.
Mon Sep 28 00:00:00 EDT 2020
Mycobacterium tuberculosis Heat-Shock Protein 16.3 Induces Macrophage M2 Polarization Through CCRL2/CX3CR1.
Inflammation
Zhang Y,Li S,Liu Q,Long R,Feng J,Qin H,Li M,Liu L,Luo J
11-4801 was used in Flow cytometry/Cell sorting to provides evidence that Mycobacterium tuberculosis (MTB) Hsp16.3 promotes macrophages to M2 phenotype and explores its underlying mechanism.
Wed Apr 01 00:00:00 EDT 2020
Cardioprotective Effects of Latifolin Against Doxorubicin-Induced Cardiotoxicity by Macrophage Polarization in Mice.
Journal of cardiovascular pharmacology
Zhang N,Shou B,Chen L,Lai X,Luo Y,Meng X,Liu R
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that latifolin prevented DOX-induced cardiac dysfunction and produced macrophage polarization in mice challenged with latifolin.
Mon Jun 01 00:00:00 EDT 2020
Progressive Degenerative Myopathy and Myosteatosis in ASNSD1-Deficient Mice.
Veterinary pathology
Vogel P,Ding ZM,Read R,DaCosta CM,Hansard M,Small DL,Ye GL,Hansen G,Brommage R,Powell DR
11-4801-82 was used in Immunohistochemistry to study the function of the asparagine synthetase domain containing 1 (ASNSD1) protein in vivo using Asnsd1-/- mice.
Tue Sep 01 00:00:00 EDT 2020
Differential Activation of Macrophages Based on Their Environment in Advanced Age.
Chonnam medical journal
Lee DY,Lim JS,Cho KA
11-4801-82 was used in Flow Cytometry to investigate the differential activity of peritoneal macrophages with or without the presence of the inflammatory drug, thioglycollate.
Wed Jan 01 00:00:00 EST 2020
BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.
eLife
Li J,Zhang L,Zheng Y,Shao R,Liang Q,Yu W,Wang H,Zou W,Wang D,Xiang J,Lin A
11-4801-82 was used in Flow Cytometry to put forward a model in which inactivation of BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of arthritis, suggesting that BAD may be a potential therapeutic target for RA.
Thu Dec 03 00:00:00 EST 2020
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF.
Stem cell research & therapy
Martins L,Gallo CC,Honda TSB,Alves PT,Stilhano RS,Rosa DS,Koh TJ,Han SW
11-4801 was used in Flow cytometry/Cell sorting to study the show if increasing the number of M1-like macrophages immediately after traumatic muscle injury can promotes muscle recovery with less fibrosis, and if this can be achieved by the transient expression of GM-CSF.
Fri Nov 06 00:00:00 EST 2020
ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.
Cell reports
Viaud M,Abdel-Wahab O,Gall J,Ivanov S,Guinamard R,Sore S,Merlin J,Ayrault M,Guilbaud E,Jacquel A,Auberger P,Wang N,Levine RL,Tall AR,Yvan-Charvet L
11-4801 was used in Flow cytometry/Cell sorting to identify somatic mutations in ABCA1 that subvert its anti-proliferative and cholesterol efflux functions and permit the progression of myeloid neoplasms.
Tue Mar 10 00:00:00 EDT 2020
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Cell reports
Castro-Dopico T,Fleming A,Dennison TW,Ferdinand JR,Harcourt K,Stewart BJ,Cader Z,Tuong ZK,Jing C,Lok LSC,Mathews RJ,Portet A,Kaser A,Clare S,Clatworthy MR
11-4801 was used in Flow cytometry/Cell sorting to identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.
Tue Jul 07 00:00:00 EDT 2020
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Cell reports
Davidson S,Efremova M,Riedel A,Mahata B,Pramanik J,Huuhtanen J,Kar G,Vento-Tormo R,Hagai T,Chen X,Haniffa MA,Shields JD,Teichmann SA
11-4801-82 was used in Immunohistochemistry to identify complex interplays and increase stromal diversity as a tumor develops, revealing that stromal cells acquire the capacity to modulate immune landscapes from early disease.
Tue May 19 00:00:00 EDT 2020
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.
Nature cell biology
Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,Sreekumar A,Rosen JM,Zhang XH
11-4801 was used in Flow cytometry/Cell sorting to demonstrate diverse myeloid cell frequencies, functionality and potential roles in immunotherapies, and highlight the need to better understand the inter-patient heterogeneity of the myeloid compartment.
Sun Sep 01 00:00:00 EDT 2019
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.
The Journal of clinical investigation
Han YH,Shin KO,Kim JY,Khadka DB,Kim HJ,Lee YM,Cho WJ,Cha JY,Lee BJ,Lee MO
11-4801 was used in Flow cytometry/Cell sorting to study the hepatic microenvironments that support the function of RORa as a polarity regulator.
Mon Mar 11 00:00:00 EDT 2019
Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1.
Molecular therapy oncolytics
Zhu Y,Hu X,Feng L,Yang Z,Zhou L,Duan X,Cheng S,Zhang W,Liu B,Zhang K
11-4801-82 was used in Flow Cytometry to develop a novel oncolytic herpes simplex virus 2 (HSV2) encoding an anti-human programmed cell death 1 (PD-1) monoclonal antibody (oHSV2-aPD1) and demostrate its therapeutic efficacy.
Fri Dec 20 00:00:00 EST 2019
BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.
American journal of physiology. Lung cellular and molecular physiology
Britto CJ,Niu N,Khanal S,Huleihel L,Herazo-Maya JD,Thompson A,Sauler M,Slade MD,Sharma L,Dela Cruz CS,Kaminski N,Cohn LE
11-4801-82 was used in Immunohistochemistry to identify a novel role for Bpifa1 in the regulation of Cxcl10-mediated PMN recruitment to the lungs via IFNγ and -λ signaling during acute inflammation.
Fri Feb 01 00:00:00 EST 2019
Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.
Purinergic signalling
Rothweiler S,Feldbrügge L,Jiang ZG,Csizmadia E,Longhi MS,Vaid K,Enjyoji K,Popov YV,Robson SC
11-4801-82 was used in Flow cytometry/Cell sorting to investigate the role of macrophage-expressed CD39 on the development of biliary injury and fibrosis in a mouse model of sclerosing cholangitis.
Sun Sep 01 00:00:00 EDT 2019
Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.
Cell reports
Tuit S,Salvagno C,Kapellos TS,Hau CS,Seep L,Oestreich M,Klee K,de Visser KE,Ulas T,Schultze JL
11-4801 was used in Flow cytometry/Cell sorting to show that a transgenic mouse tumor model can yield a TAM signature relevant for human breast cancer outcome prognosis and provide a generalizable strategy for determining and applying immune cell signatures provided the murine model reflects the human disease.
Tue Oct 29 00:00:00 EDT 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
11-4801-82 was used in Flow cytometry/Cell sorting to show that CD160 is not essential for NKT cell development.
Mon Jul 22 00:00:00 EDT 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
11-4801 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Deficiency in Vascular Smooth Muscle Cells Prevents Arteriovenous Fistula Failure Despite Chronic Kidney Disease.
Journal of the American Heart Association
Ding X,Chen J,Wu C,Wang G,Zhou C,Chen S,Wang K,Zhang A,Ye P,Wu J,Chen S,Zhang H,Xu K,Wang S,Xia J
11-4801 was used in Flow cytometry/Cell sorting to identify nucleotide-binding oligomerization domain-like receptor protein 3 as a possible treatment target for arteriovenous fistula failure.
Tue Jan 08 00:00:00 EST 2019
Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models.
Scientific reports
Kang SA,Park MK,Park SK,Choi JH,Lee DI,Song SM,Yu HS
11-4801-82 was used in Flow cytometry/Cell sorting to compare the effects of M1 and M2 macrophages obtained from Trichinella spiralis-infected mice with those of T. spiralis excretory/secretory (ES) protein-treated macrophages on experimental intestinal inflammation and allergic airway inflammation.
Thu Apr 25 00:00:00 EDT 2019
Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis.
Cell metabolism
Choi WM,Kim HH,Kim MH,Cinar R,Yi HS,Eun HS,Kim SH,Choi YJ,Lee YS,Kim SY,Seo W,Lee JH,Shim YR,Kim YE,Yang K,Ryu T,Hwang JH,Lee CH,Choi HS,Gao B,Kim W,Kim SK,Kunos G,Jeong WI
11-4801-82 was used in Flow cytometry/Cell sorting to investigate hepatocyte cannabinoid receptor-1 in alcoholic liver disease and lipogenesis.
Tue Nov 05 00:00:00 EST 2019
The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.
Scientific reports
Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC
11-4801-82 was used in Flow Cytometry to show that nBMP2 plays a role in Ca2+ response.
Wed Jan 30 00:00:00 EST 2019
Isolating Immune Cells from Mouse Embryonic Skin.
Methods in molecular biology (Clifton, N.J.)
Kurbet AS,Raghavan S
11-4801-82 was used in Flow cytometry/Cell sorting to present a detailed protocol for isolating monocytes, macrophages, and epidermal dendritic T cell populations from embryonic skin.
Mon Jun 03 00:00:00 EDT 2019
Circuit Design Features of a Stable Two-Cell System.
Cell
Zhou X,Franklin RA,Adler M,Jacox JB,Bailis W,Shyer JA,Flavell RA,Mayo A,Alon U,Medzhitov R
11-4801 was used in Flow cytometry/Cell sorting to illustrate principles of cell circuit design and provide a quantitative perspective on cell interactions.
Thu Feb 08 00:00:00 EST 2018
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
11-4801 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.
Immunity
Li J,Lee Y,Li Y,Jiang Y,Lu H,Zang W,Zhao X,Liu L,Chen Y,Tan H,Yang Z,Zhang MQ,Mak TW,Ni L,Dong C
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that increased B7S1 expression in myeloid cells from human hepatocellular carcinoma is correlated with CD8+ T cell dysfunction.
Tue Apr 17 00:00:00 EDT 2018
Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.
Frontiers in immunology
Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ
11-4801 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.
Sun Jan 03 00:00:00 EST 2021
Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.
Journal of leukocyte biology
Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J
11-4801-82 was used in Flow Cytometry to explore a previously unidentified pathway of AMφ-PMN cross-talk, which causes enhanced PMN necroptosis and subsequent exaggerated post-HS lung inflammation.
Thu Feb 01 00:00:00 EST 2018
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing.
The American journal of pathology
Prystaz K,Kaiser K,Kovtun A,Haffner-Luntzer M,Fischer V,Rapp AE,Liedert A,Strauss G,Waetzig GH,Rose-John S,Ignatius A
11-4801 was used in Flow cytometry/Cell sorting to study the mechanisms by which IL-6 regulates bone healing.
Thu Feb 01 00:00:00 EST 2018
Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies.
Disease models & mechanisms
Parada-Kusz M,Penaranda C,Hagedorn EJ,Clatworthy A,Nair AV,Henninger JE,Ernst C,Li B,Riquelme R,Jijon H,Villablanca EJ,Zon LI,Hung D,Allende ML
11-4801 was used in Flow cytometry/Cell sorting to develop a xenotransplantation technique that transiently generates hundreds of haematopoietic tissue chimeric embryos by transplanting murine bone marrow cells into zebrafish blastulae.
Mon Nov 05 00:00:00 EST 2018
The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism.
Journal of immunology (Baltimore, Md. : 1950)
Fensterheim BA,Young JD,Luan L,Kleinbard RR,Stothers CL,Patil NK,McAtee-Pereira AG,Guo Y,Trenary I,Hernandez A,Fults JB,Williams DL,Sherwood ER,Bohannon JK
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that MPLA prompts resistance to infection, in part, by inducing a sustained and dynamic metabolic program in macrophages.
Fri Jun 01 00:00:00 EDT 2018
Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice.
Endocrinology
Endo-Umeda K,Nakashima H,Umeda N,Seki S,Makishima M
11-4801 was used in Flow cytometry/Cell sorting to study the role fof LXRα in the pathogenesis of steatohepatitis.
Thu Mar 01 00:00:00 EST 2018
Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.
Infection and immunity
Denham ST,Verma S,Reynolds RC,Worne CL,Daugherty JM,Lane TE,Brown JCS
11-4801 was used in Flow cytometry/Cell sorting to show that exo-glucuronoxylomannan (exo-GXM) performs a different role from capsule GXM during infection, altering cell size and suppressing inflammation.
Thu Mar 01 00:00:00 EST 2018
Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δp66 Borrelia burgdorferi.
Infection and immunity
Curtis MW,Hahn BL,Zhang K,Li C,Robinson RT,Coburn J
Thu Feb 01 00:00:00 EST 2018
Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma.
Naunyn-Schmiedeberg's archives of pharmacology
Kaiser K,Prystaz K,Vikman A,Haffner-Luntzer M,Bergdolt S,Strauss G,Waetzig GH,Rose-John S,Ignatius A
11-4801 was used in Flow cytometry/Cell sorting to suggest that selective IL-6 trans-signaling inhibition may have therapeutic potential to treat fracture healing complications in patients with concomitant injuries.
Tue May 01 00:00:00 EDT 2018
TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase.
Frontiers in microbiology
Gan T,Yang Y,Hu F,Chen X,Zhou J,Li Y,Xu Y,Wang H,Chen Y,Zhang M
11-4801-82 was used in Flow Cytometry to demonstrate that poly I:C can induce pulmonary neutrophil extracellular traps.
Thu Oct 01 00:00:00 EDT 2020
MAIT cells contribute to protection against lethal influenza infection in vivo.
Nature communications
van Wilgenburg B,Loh L,Chen Z,Pediongco TJ,Wang H,Shi M,Zhao Z,Koutsakos M,Nüssing S,Sant S,Wang Z,D'Souza C,Jia X,Almeida CF,Kostenko L,Eckle SBG,Meehan BS,Kallies A,Godfrey DI,Reading PC,Corbett AJ,McCluskey J,Klenerman P,Kedzierska K,Hinks TSC
11-4801 was used in Flow cytometry/Cell sorting to study the role of mucosal associated invariant T cells in protection against respiratory viral infections.
Fri Nov 09 00:00:00 EST 2018
DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.
The Journal of biological chemistry
Lao Y,Yang K,Wang Z,Sun X,Zou Q,Yu X,Cheng J,Tong X,Yeh ETH,Yang J,Yi J
11-4801 was used in Flow cytometry/Cell sorting to indicate that SENP3 potentiates lipopolysaccharide-induced Toll-like receptor 4 signalling via MKK7 deSUMOylation leading to enhancement in JNK phosphorylation and the downstream events.
Fri Mar 16 00:00:00 EDT 2018
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.
Nature communications
Cambré I,Gaublomme D,Burssens A,Jacques P,Schryvers N,De Muynck A,Meuris L,Lambrecht S,Carter S,de Bleser P,Saeys Y,Van Hoorebeke L,Kollias G,Mack M,Simoens P,Lories R,Callewaert N,Schett G,Elewaut D
11-4801 was used in Flow cytometry/Cell sorting to study the role of mechanical strain in controlling site-specific localisation of inflammation and tissue damage in arthritis.
Mon Nov 05 00:00:00 EST 2018
Adipose PD-L1 Modulates PD-1/PD-L1 Checkpoint Blockade Immunotherapy Efficacy in Breast Cancer.
Oncoimmunology
Wu B,Sun X,Gupta HB,Yuan B,Li J,Ge F,Chiang HC,Zhang X,Zhang C,Zhang D,Yang J,Hu Y,Curiel TJ,Li R
11-4801 was used in Flow cytometry/Cell sorting to compare the expression of PD-L1 in mature adipocytes versus preadipocytes.
Wed Oct 04 00:00:00 EDT 2023
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates.
mBio
Schager AE,Dominguez-Medina CC,Necchi F,Micoli F,Goh YS,Goodall M,Flores-Langarica A,Bobat S,Cook CNL,Arcuri M,Marini A,King LDW,Morris FC,Anderson G,Toellner KM,Henderson IR,López-Macías C,MacLennan CA,Cunningham AF
11-4801 was used in Flow cytometry/Cell sorting to study how antibody responses to bacterial antigens develop and how vaccines like generalised modules for membrane antigens can work and help prevent infection.
Tue Mar 06 00:00:00 EST 2018
Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.
Arteriosclerosis, thrombosis, and vascular biology
Wang L,Wang Y,Zhang C,Li J,Meng Y,Dou M,Noguchi CT,Di L
11-4801-82 was used in Flow cytometry/Cell sorting to examine the potential mechanism by which GSK3 in modulating obesity-induced visceral adipose tissue (VAT) inflammation.
Sat Sep 01 00:00:00 EDT 2018
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity.
Nature communications
Kubota T,Inoue M,Kubota N,Takamoto I,Mineyama T,Iwayama K,Tokuyama K,Moroi M,Ueki K,Yamauchi T,Kadowaki T
11-4801 was used in Flow cytometry/Cell sorting to study the mechanism by which the downregulation of Irs2 in macrophages is responsible for systemic insulin resistance.
Mon Nov 19 00:00:00 EST 2018
Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes.
JCI insight
Arifuzzaman M,Ang WXG,Choi HW,Nilles ML,St John AL,Abraham SN
11-4801-82 was used in Flow Cytometry to examine how Yersinia pestis converts immunocytes recruited by host to contain the pathogen into vehicles for bacterial dispersal and the role of immune cell death in this context.
Thu Sep 20 00:00:00 EDT 2018
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
11-4801-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
The Journal of clinical investigation
Doran AC,Ozcan L,Cai B,Zheng Z,Fredman G,Rymond CC,Dorweiler B,Sluimer JC,Hsieh J,Kuriakose G,Tall AR,Tabas I
11-4801-82 was used in Flow Cytometry to identify a macrophage CaMKIIγ/ATF6/LXRα/MerTK pathway as a key factor in the development of necrotic atherosclerotic plaques.
Wed Nov 01 00:00:00 EDT 2017
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
The Journal of experimental medicine
Alloatti A,Rookhuizen DC,Joannas L,Carpier JM,Iborra S,Magalhaes JG,Yatim N,Kozik P,Sancho D,Albert ML,Amigorena S
11-4801 was used in Flow cytometry/Cell sorting to determine that Sec22b-dependent cross-presentation in dendritic cells is required to initiate CD8 T cell responses to dead cells, and induce effective anti-tumour immune responses during anti-PD-1 treatment.
Mon Aug 07 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
11-4801 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
11-4801-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Quaking Deficiency Amplifies Inflammation in Experimental Endotoxemia via the Aryl Hydrocarbon Receptor/Signal Transducer and Activator of Transcription 1-NF-κB Pathway.
Frontiers in immunology
Wang L,Zhai DS,Ruan BJ,Xu CM,Ye ZC,Lu HY,Jiang YH,Wang ZY,Xiang A,Yang Y,Yuan JL,Lu ZF
11-4801 was used in Flow cytometry/Cell sorting to suggest a role for QKI in restraining overt innate immune responses by regulating the Ahr/STAT1-NF-κB pathway.
Wed Nov 20 00:00:00 EST 2019
Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.
Journal of lipid research
De Giorgi M,Enjyoji K,Jiang G,Csizmadia E,Mitsuhashi S,Gumina RJ,Smolenski RT,Robson SC
11-4801 was used in Flow cytometry/Cell sorting to further investigate the complex, potentially divergent roles of Cd39 in the development of atherosclerosis in mice.
Sat Jul 01 00:00:00 EDT 2017
Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Houthuijzen JM,Oosterom I,Hudson BD,Hirasawa A,Daenen LGM,McLean CM,Hansen SVF,van Jaarsveld MTM,Peeper DS,Jafari Sadatmand S,Roodhart JML,van de Lest CHA,Ulven T,Ishihara K,Milligan G,Voest EE
11-4801 was used in Flow cytometry/Cell sorting to show that 16:4(n-3) exerts its effect by activating splenic F4/80(+)/CD11b(low) macrophages, which results in production of chemoprotective lysophosphatidylcholines (LPCs).
Mon May 01 00:00:00 EDT 2017
The Cytokine Response to Lipopolysaccharide Does Not Predict the Host Response to Infection.
Journal of immunology (Baltimore, Md. : 1950)
Fensterheim BA,Guo Y,Sherwood ER,Bohannon JK
11-4801 was used in Flow cytometry/Cell sorting to conclude the magnitude of LPS-elicited cytokine production is not indicative of antimicrobial immunity after exposure to TLR ligands.
Sat Apr 15 00:00:00 EDT 2017
Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Movassagh H,Shan L,Mohammed A,Halayko AJ,Gounni AS
11-4801 was used in Flow cytometry/Cell sorting to identify Semaphorin 3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events.
Wed Mar 01 00:00:00 EST 2017
Phenotypic switch in lung interstitial macrophage polarization in an ovalbumin-induced mouse model of asthma.
Experimental and therapeutic medicine
Nie H,Wang A,He Q,Yang Q,Liu L,Zhang G,Huang Y,Ding X,Yu H,Hu S
11-4801-82 was used in Flow Cytometry to observe the phenotypic characteristics of lung interstitial macrophages in an ovalbumin-induced mouse model of asthma.
Tue Aug 01 00:00:00 EDT 2017
Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.
Oncotarget
Zamanian-Daryoush M,Lindner DJ,DiDonato JA,Wagner M,Buffa J,Rayman P,Parks JS,Westerterp M,Tall AR,Hazen SL
11-4801 was used in Flow cytometry/Cell sorting to study the tumour protective and immune regulatory role of circulating cholesterol homeostasis in murine bladder cancer and melanoma.
Fri Sep 22 00:00:00 EDT 2017
Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity.
Wellcome open research
Dutton EE,Camelo A,Sleeman M,Herbst R,Carlesso G,Belz GT,Withers DR
11-4801-82 was used in Flow Cytometry to compare the innate lymphoid cell populations at different sites in mice with defective T cell immunity.
Sat Jan 09 00:00:00 EST 2021
Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.
The Journal of biological chemistry
Guo X,Li T,Xu Y,Xu X,Zhu Z,Zhang Y,Xu J,Xu K,Cheng H,Zhang X,Ke Y
11-4801 was used in Flow cytometry/Cell sorting to study the mechanism by which M2-polarised macrophages are associated with pulmonary fibrosis.
Fri Aug 25 00:00:00 EDT 2017
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Nature communications
Song Y,Lai L,Chong Z,He J,Zhang Y,Xue Y,Xie Y,Chen S,Dong P,Chen L,Chen Z,Dai F,Wan X,Xiao P,Cao X,Liu Y,Wang Q
11-4801 was used in Flow cytometry/Cell sorting to identify FBXW7 as an important interacting partner for RIG-I.
Mon Mar 13 00:00:00 EDT 2017
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs.
Nature communications
Niu Z,Shi Q,Zhang W,Shu Y,Yang N,Chen B,Wang Q,Zhao X,Chen J,Cheng N,Feng X,Hua Z,Ji J,Shen P
11-4801-82 was used in Flow Cytometry to report that caspase-1 promotes tumor-associated macrophage differentiation by cleaving peroxisome proliferator-activated receptor gamma (PPARγ) at Asp64, thus generating a 41 kDa fragment.
Tue Oct 03 00:00:00 EDT 2017
MKL1 expressed in macrophages contributes to the development of murine colitis.
Scientific reports
An J,Nagaishi T,Watabe T,Naruse TK,Watanabe M,Kimura A
11-4801 was used in Flow cytometry/Cell sorting to indicates that MKL1 crucially contributes to the development of colitis via the regulation of the function of macrophages.
Fri Oct 20 00:00:00 EDT 2017
Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity.
The Journal of allergy and clinical immunology
Everaere L,Ait-Yahia S,Molendi-Coste O,Vorng H,Quemener S,LeVu P,Fleury S,Bouchaert E,Fan Y,Duez C,de Nadai P,Staels B,Dombrowicz D,Tsicopoulos A
11-4801 was used in Flow cytometry/Cell sorting to indicate that high-fat diet-induced obesity might exacerbate allergic airway inflammation through mechanisms involving ILC2s and ILC3s.
Tue Nov 01 00:00:00 EDT 2016
Tissue damage negatively regulates LPS-induced macrophage necroptosis.
Cell death and differentiation
Li Z,Scott MJ,Fan EK,Li Y,Liu J,Xiao G,Li S,Billiar TR,Wilson MA,Jiang Y,Fan J
11-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism and role of trauma/tissue damage in the regulation of LPS-induced MΦ necroptosis.
Thu Sep 01 00:00:00 EDT 2016
Critical Role of the Disintegrin Metalloprotease ADAM-like Decysin-1 [ADAMDEC1] for Intestinal Immunity and Inflammation.
Journal of Crohn's & colitis
O'Shea NR,Chew TS,Dunne J,Marnane R,Nedjat-Shokouhi B,Smith PJ,Bloom SL,Smith AM,Segal AW
11-4801 was used in Flow cytometry/Cell sorting to investigate how reduced expression of the ADAMDEC1 peptidase protein may lead to decreased protection from bacterial and chemical insults, characteristic of Crohn's disease.
Thu Dec 01 00:00:00 EST 2016
Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury.
Journal of leukocyte biology
Bohannon JK,Luan L,Hernandez A,Afzal A,Guo Y,Patil NK,Fensterheim B,Sherwood ER
11-4801 was used in Flow cytometry/Cell sorting to provide evidence that monophosphoryl lipid A-induced G-CSF facilitates a robust immune response via neutrophils to the site of infection after burn injury.
Fri Apr 01 00:00:00 EDT 2016
Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation.
The FEBS journal
Jin X,Liu L,Zhou Z,Ge J,Yao T,Shen C
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that pioglitazone blocks classical activation of macrophages and attenuates inflammation in mouse models of diabetes.
Wed Jun 01 00:00:00 EDT 2016
Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression.
Journal of diabetes research
Zhou Z,Tang Y,Jin X,Chen C,Lu Y,Liu L,Shen C
11-4801 was used in Flow cytometry/Cell sorting to investigate the use of metformin to treat AGEs-induced inflammatory response in macrophages.
Tue Jun 06 00:00:00 EDT 2017
Activation and increase of radio-sensitive CD11b+ recruited Kupffer cells/macrophages in diet-induced steatohepatitis in FGF5 deficient mice.
Scientific reports
Nakashima H,Nakashima M,Kinoshita M,Ikarashi M,Miyazaki H,Hanaka H,Imaki J,Seki S
11-4801 was used in Flow cytometry/Cell sorting to suggest a role for recruited CD11b+ CD68+ Kupffer cells/MΦs in diet-induced steatohepatitis and fibrosis.
Thu Oct 06 00:00:00 EDT 2016
Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema.
JCI insight
Gardenier JC,Hespe GE,Kataru RP,Savetsky IL,Torrisi JS,Nores GDG,Dayan JJ,Chang D,Zampell J,Martínez-Corral I,Ortega S,Mehrara BJ
11-4801 was used in Flow cytometry/Cell sorting to show that inflammatory changes after lymphatic injury play a key role in the pathophysiology of lymphedema.
Thu Sep 22 00:00:00 EDT 2016
Tim-3 promotes tumor-promoting M2 macrophage polarization by binding to STAT1 and suppressing the STAT1-miR-155 signaling axis.
Oncoimmunology
Jiang X,Zhou T,Xiao Y,Yu J,Dou S,Chen G,Wang R,Xiao H,Hou C,Wang W,Shi Q,Feng J,Ma Y,Shen B,Li Y,Han G
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that Tim-3 polarizes macrophages by directly binding to STAT1 via residue Y256 and Y263 in its intracellular tail and inhibiting the STAT1-miR-155-SOCS1 signaling axis.
Wed Nov 09 00:00:00 EST 2022
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
11-4801 was used in Flow cytometry/Cell sorting to show that EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Thu Jun 02 00:00:00 EDT 2016
Lack of immunoediting in murine pancreatic cancer reversed with neoantigen.
JCI insight
Evans RA,Diamond MS,Rech AJ,Chao T,Richardson MW,Lin JH,Bajor DL,Byrne KT,Stanger BZ,Riley JL,Markosyan N,Winograd R,Vonderheide RH
11-4801 was used in Flow cytometry/Cell sorting to evaluate T cell immunity in an autochthonous mouse model of pancreatic cancer and identify a low mutational burden, absence of predicted neoepitopes derived from tumour mutations, and resistance to checkpoint immunotherapy.
Thu Sep 08 00:00:00 EDT 2016
Splenic Leukocytes Traffic to the Thyroid and Produce a Novel TSHβ Isoform during Acute Listeria monocytogenes Infection in Mice.
PloS one
Montufar-Solis D,Klein JR
11-4801 was used in Immunofluorescence to show that within three days of systemic infection of mice with Listeria monocytogenes, splenic leukocytes synthesized elevated levels of TSHβv.
Mon Jul 11 00:00:00 EDT 2016
Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.
Scientific reports
Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M
11-4801 was used in Flow cytometry/Cell sorting to indicate that NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis.
Mon Jan 18 00:00:00 EST 2016
Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.
Scientific reports
Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M
11-4801 was used in Flow cytometry/Cell sorting to indicate that NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis.
Mon Jan 18 00:00:00 EST 2016
Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease.
Scientific reports
Wu XQ,Yang Y,Li WX,Cheng YH,Li XF,Huang C,Meng XM,Wu BM,Liu XH,Zhang L,Lv XW,Li J
11-4801 was used in Flow cytometry/Cell sorting to unveils the role of TERT in macrophage polarization and the cross-talk between TERT and p65.
Mon Jan 04 00:00:00 EST 2016
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.
The Journal of clinical investigation
Fond AM,Lee CS,Schulman IG,Kiss RS,Ravichandran KS
11-4801 was used in Flow cytometry/Cell sorting to identify a membrane-initiated pathway that is triggered by apoptotic cells to enhance ABCA1 within engulfing phagocytes.
Wed Jul 01 00:00:00 EDT 2015
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm.
Arteriosclerosis, thrombosis, and vascular biology
Usui F,Shirasuna K,Kimura H,Tatsumi K,Kawashima A,Karasawa T,Yoshimura K,Aoki H,Tsutsui H,Noda T,Sagara J,Taniguchi S,Takahashi M
Thu Jan 01 00:00:00 EST 2015
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.
Journal of virology
Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T
11-4801 was used in Flow cytometry/Cell sorting to demonstrate the enormous functional and genetic plasticity of monocytes infiltrating the liver after inflammation.
Fri May 01 00:00:00 EDT 2015
Expression of Blimp-1 in dendritic cells modulates the innate inflammatory response in dextran sodium sulfate-induced colitis.
Molecular medicine (Cambridge, Mass.)
Kim SJ,Goldstein J,Dorso K,Merad M,Mayer L,Crawford JM,Gregersen PK,Diamond B
11-4801 was used in Flow cytometry/Cell sorting to describe a novel mechanism of contribution of Blimp-1 for the pathogenesis of inflammatory bowel diseases.
Tue Mar 24 00:00:00 EDT 2015
Expression of Blimp-1 in dendritic cells modulates the innate inflammatory response in dextran sodium sulfate-induced colitis.
Molecular medicine (Cambridge, Mass.)
Kim SJ,Goldstein J,Dorso K,Merad M,Mayer L,Crawford JM,Gregersen PK,Diamond B
11-4801 was used in Flow cytometry/Cell sorting to describe a novel mechanism of contribution of Blimp-1 for the pathogenesis of inflammatory bowel diseases.
Tue Mar 24 00:00:00 EDT 2015
Macrophages are required for host survival in experimental urogenital schistosomiasis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fu CL,Odegaard JI,Hsieh MH
11-4801 was used in Flow cytometry/Cell sorting to define how macrophages mediate bladder granulomogenesis and fibrosis in a mouse model of urogenital schistosomiasis.
Thu Jan 01 00:00:00 EST 2015
CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice.
Journal of immunology (Baltimore, Md. : 1950)
Burrack KS,Montgomery SA,Homann D,Morrison TE
11-4801 was used in Flow cytometry/Cell sorting to demonstrate an important but limited and tissue-specific role for CD8+ T lymphocytes in the control of pathogenic RRV infection.
Thu Jan 15 00:00:00 EST 2015
B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Wong EB,Soni C,Chan AY,Domeier PP,Abraham T,Limaye N,Khan TN,Elias MJ,Chodisetti SB,Wakeland EK,Rahman ZS
11-4801 was used in Flow cytometry/Cell sorting to investigate the effect of B cell-intrinsic polymorphic SLAM receptors on germinal center B cell tolerance.
Fri May 01 00:00:00 EDT 2015
Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.
International journal for parasitology
Bourke CD,Prendergast CT,Sanin DE,Oulton TE,Hall RJ,Mountford AP
11-4801 was used in Flow cytometry/Cell sorting to indicate that S.mansoni cercariae and their excretory/secretory products act directly upon epidermal keratinocytes.
Sun Mar 01 00:00:00 EST 2015
Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.
American journal of physiology. Renal physiology
Yuan A,Lee Y,Choi U,Moeckel G,Karihaloo A
11-4801 was used in Flow cytometry/Cell sorting to study the expression of CXCR4 following renal injury, and the role it plays in augmenting the fibrotic response.
Sun Mar 01 00:00:00 EST 2015
Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.
BioMed research international
Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC
11-4801-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.
Mon Aug 01 00:00:00 EDT 2016
Neonatal microbial colonization in mice promotes prolonged dominance of CD11b(+)Gr-1(+) cells and accelerated establishment of the CD4(+) T cell population in the spleen.
Immunity, inflammation and disease
Kristensen MB,Metzdorff SB,Bergström A,Damlund DS,Fink LN,Licht TR,Frøkiær H
11-4801 was used in Flow cytometry/Cell sorting to assess the microbial influence on postnatal haematopoiesis.
Tue Sep 01 00:00:00 EDT 2015
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
PloS one
Incio J,Suboj P,Chin SM,Vardam-Kaur T,Liu H,Hato T,Babykutty S,Chen I,Deshpande V,Jain RK,Fukumura D
11-4801 was used in Flow cytometry/Cell sorting to examine the effect of metformin on pancreatic stellate cell activity, fibrosis and inflammation in pancreatic ductal adenocarcinomas.
Tue Jun 21 00:00:00 EDT 2016
Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy.
PloS one
Nishiyama K,Nakashima H,Ikarashi M,Kinoshita M,Nakashima M,Aosasa S,Seki S,Yamamoto J
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of Kupffer cells in liver regeneration after partial hepatectomy in mice.
Mon May 23 00:00:00 EDT 2016
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Nature communications
Ito M,Shichita T,Okada M,Komine R,Noguchi Y,Yoshimura A,Morita R
11-4801 was used in Flow cytometry/Cell sorting to report that Bruton's tyrosine kinase (BTK) is an essential component of the NLRP3 inflammasome, in which BTK physically interacts with ASC and NLRP3.
Wed Jun 10 00:00:00 EDT 2015
Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota.
Nature communications
Chang CJ,Lin CS,Lu CC,Martel J,Ko YF,Ojcius DM,Tseng SF,Wu TR,Chen YY,Young JD,Lai HC
Tue Jun 23 00:00:00 EDT 2015
Infection with Salmonella enterica Serovar Typhimurium Leads to Increased Proportions of F4/80+ Red Pulp Macrophages and Decreased Proportions of B and T Lymphocytes in the Spleen.
PloS one
Rosche KL,Aljasham AT,Kipfer JN,Piatkowski BT,Konjufca V
11-4801 was used in Flow cytometry/Cell sorting to investigate the cause of Salmonella-induced splenomegaly, showing that significantly increased proportions of F4/80+ red pulp macrophages likely play a major role.
Thu Apr 21 00:00:00 EDT 2016
Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs.
The Journal of biological chemistry
Chen R,Zhang K,Chen H,Zhao X,Wang J,Li L,Cong Y,Ju Z,Xu D,Williams BR,Jia J,Liu JP
11-4801 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which TERC and TERT participate in lung diseases.
Fri Dec 25 00:00:00 EST 2015
Muc5b is required for airway defence.
Nature
Roy MG,Livraghi-Butrico A,Fletcher AA,McElwee MM,Evans SE,Boerner RM,Alexander SN,Bellinghausen LK,Song AS,Petrova YM,Tuvim MJ,Adachi R,Romo I,Bordt AS,Bowden MG,Sisson JH,Woodruff PG,Thornton DJ,Rousseau K,De la Garza MM,Moghaddam SJ,Karmouty-Quintana H,Blackburn MR,Drouin SM,Davis CW,Terrell KA,Grubb BR,O'Neal WK,Flores SC,Cota-Gomez A,Lozupone CA,Donnelly JM,Watson AM,Hennessy CE,Keith RC,Yang IV,Barthel L,Henson PM,Janssen WJ,Schwartz DA,Boucher RC,Dickey BF,Evans CM
11-4801 was used in Immunohistochemistry to provide a refined framework for designing targeted therapies to control mucin secretion and restore MCC.
Thu Jan 16 00:00:00 EST 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
11-4801 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.
Circulation research
Weirather J,Hofmann UD,Beyersdorf N,Ramos GC,Vogel B,Frey A,Ertl G,Kerkau T,Frantz S
11-4801 was used in Flow cytometry/Cell sorting to determine the mechanisms by which regulatory T cells promote an appropriate healing response after a heart attack.
Fri Jun 20 00:00:00 EDT 2014
LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis.
The Journal of clinical investigation
Nakamura T,Hamuro J,Takaishi M,Simmons S,Maruyama K,Zaffalon A,Bentley AJ,Kawasaki S,Nagata-Takaoka M,Fullwood NJ,Itami S,Sano S,Ishii M,Barrandon Y,Kinoshita S
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of corneal stem cells in cornea homeostasis, showing that LRIG1 inhibits STAT3-dependent inflammation to maintain homeostasis.
Wed Jan 01 00:00:00 EST 2014
The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor.
Cancer immunology research
Swierczak A,Cook AD,Lenzo JC,Restall CM,Doherty JP,Anderson RL,Hamilton JA
11-4801 was used in Flow cytometry/Cell sorting to investigate the effect of blocking CSF-1R/CSF-1 signalling in breast cancer.
Fri Aug 01 00:00:00 EDT 2014
Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance.
Diabetes
Liu PS,Lin YW,Lee B,McCrady-Spitzer SK,Levine JA,Wei LN
11-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms that regulate the dynamics of adipose tissue macrophages and contribute to adipose tissue remodelling.
Mon Dec 01 00:00:00 EST 2014
The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis.
PLoS pathogens
Dumas A,Amiable N,de Rivero Vaccari JP,Chae JJ,Keane RW,Lacroix S,Vallières L
11-4801 was used in Flow cytometry/Cell sorting to identify the first microbial molecule that activates pyrin, a mechanism by which infections may influence MS and a potential therapeutic target for immune disorders.
Thu May 01 00:00:00 EDT 2014
Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.
Journal of leukocyte biology
Honda H,Nagai Y,Matsunaga T,Okamoto N,Watanabe Y,Tsuneyama K,Hayashi H,Fujii I,Ikutani M,Hirai Y,Muraguchi A,Takatsu K
11-4801 was used in Flow cytometry/Cell sorting to investigate how isoliquiritigenin is a potential drug target for treatment of NLRP3 inflammasome-associated inflammatory diseases.
Mon Dec 01 00:00:00 EST 2014
Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tani Y,Isobe Y,Imoto Y,Segi-Nishida E,Sugimoto Y,Arai H,Arita M
11-4801 was used in Immunocytochemistry to demonstrate that eosinophils control the resolution of inflammation and draining lymph node hypertrophy through proresolving lipid mediators and the CXCL13 pathway.
Mon Sep 01 00:00:00 EDT 2014
Eicosapentaenoic acid is converted via ω-3 epoxygenation to the anti-inflammatory metabolite 12-hydroxy-17,18-epoxyeicosatetraenoic acid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kubota T,Arita M,Isobe Y,Iwamoto R,Goto T,Yoshioka T,Urabe D,Inoue M,Arai H
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that 7,18-epoxyeicosatetraenoic acid (17,18-EpETE) derived from dietary eicosapentaenoic acid is converted to a potent bioactive metabolite 12-OH-17,18-EpETE, which may generate an endogenous anti-inflammatory metabolic pathway.
Sat Feb 01 00:00:00 EST 2014
CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice.
Journal of immunology (Baltimore, Md. : 1950)
Bignon A,Gaudin F,Hémon P,Tharinger H,Mayol K,Walzer T,Loetscher P,Peuchmaur M,Berrebi D,Balabanian K
11-4801 was used in Flow cytometry/Cell sorting to define a pivotal role for CCR4 in the recruitment of T and mononuclear phagocyte cells to inflamed kidneys of lupus-prone mice.
Sat Feb 01 00:00:00 EST 2014
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
International immunology
Iwata A,Kawashima S,Kobayashi M,Okubo A,Kawashima H,Suto A,Hirose K,Nakayama T,Nakajima H
11-4801 was used in Flow cytometry/Cell sorting to indicate the importance of iDCs in the induction of AHR as downstream effector cells in Th2 cell-mediated asthmatic responses.
Sat Feb 01 00:00:00 EST 2014
Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation.
Investigative ophthalmology & visual science
Li X,Gu X,Boyce TM,Zheng M,Reagan AM,Qi H,Mandal N,Cohen AW,Callegan MC,Carr DJ,Elliott MH
11-4801 was used in Flow cytometry/Cell sorting to examine the effect of Caveolin-1 ablation on the sensitivity of the retina to inflammation.
Tue Aug 26 00:00:00 EDT 2014
Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo.
Infection and immunity
Xu SX,Gilmore KJ,Szabo PA,Zeppa JJ,Baroja ML,Haeryfar SM,McCormick JK
11-4801 was used in Flow cytometry/Cell sorting to study host immune responses to superantigen toxins released by S. aureus.
Mon Sep 01 00:00:00 EDT 2014
Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.
PloS one
Nouri M,Bredberg A,Weström B,Lavasani S
11-4801 was used in Flow cytometry/Cell sorting to show that disruption of intestinal homeostasis is an early and immune-mediated event in experimental autoimmune encephalomyelitis.
Thu May 14 00:00:00 EDT 2015
Kynurenine production mediated by indoleamine 2,3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis.
Biochimica et biophysica acta
Ohtaki H,Ito H,Ando K,Ishikawa T,Hoshi M,Ando T,Takamatsu M,Hara A,Moriwaki H,Saito K,Seishima M
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that Kynurenine and interferon induced by administration with hepatitis B virus-specific cytotoxic T lymphocytes are cooperatively involved in the progression of liver injury in acute hepatitis model.
Mon Sep 01 00:00:00 EDT 2014
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
11-4801 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.
Mon Jul 06 00:00:00 EDT 2015
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
PloS one
Ikeda T,Hirata S,Takamatsu K,Haruta M,Tsukamoto H,Ito T,Uchino M,Ando Y,Nagafuchi S,Nishimura Y,Senju S
11-4801 was used in Flow cytometry/Cell sorting to investigate the effect of embryonic stem cell-derived dendritic cells on autoimmunity, showing that suppression of Th1-mediated autoimmunity occurs in NOD and EAE mice.
Thu Dec 17 00:00:00 EST 2015
The macrophage A2B adenosine receptor regulates tissue insulin sensitivity.
PloS one
Johnston-Cox H,Eisenstein AS,Koupenova M,Carroll S,Ravid K
11-4801 was used in Flow cytometry/Cell sorting to determine a mechanism for high fat diet-induced tissue inflammation and insulin resistance.
Mon Jan 12 00:00:00 EST 2015
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
PloS one
Deroost K,Lays N,Pham TT,Baci D,Van den Eynde K,Komuta M,Prato M,Roskams T,Schwarzer E,Opdenakker G,Van den Steen PE
11-4801 was used in Flow cytometry/Cell sorting to elucidate the contribution of hemozoin to hepatic injury in mouse malaria models.
Tue Jan 26 00:00:00 EST 2016
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Nature immunology
Mascanfroni ID,Yeste A,Vieira SM,Burns EJ,Patel B,Sloma I,Wu Y,Mayo L,Ben-Hamo R,Efroni S,Kuchroo VK,Robson SC,Quintana FJ
11-4801 was used in Flow cytometry/Cell sorting to assess the regulation of T cells by dendritic cells.
Tue Oct 01 00:00:00 EDT 2013
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.
The EMBO journal
Petersen B,Wolf M,Austermann J,van Lent P,Foell D,Ahlmann M,Kupas V,Loser K,Sorg C,Roth J,Vogl T
11-4801 was used in Flow cytometry/Cell sorting to study the role of TLR-4 ligand Mrp8/14 in inflammation and adaptive immunity.
Wed Jan 09 00:00:00 EST 2013
Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5.
Autophagy
Song X,Zhang X,Wang X,Zhu F,Guo C,Wang Q,Shi Y,Wang J,Chen Y,Zhang L
11-4801 was used in Flow cytometry/Cell sorting to show that PDCD4 negatively regulates autophagy by targeting ATG5, providing a novel mechanism for tumor suppression.
Wed May 01 00:00:00 EDT 2013
B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells.
Proceedings of the National Academy of Sciences of the United States of America
Kobayashi Y,Iwata A,Suzuki K,Suto A,Kawashima S,Saito Y,Owada T,Kobayashi M,Watanabe N,Nakajima H
11-4801 was used in Flow cytometry/Cell sorting to elucidate the role of BTLA expressed on innate cells for controlling overwhelming immune responses.
Tue Mar 26 00:00:00 EDT 2013
Adipose tissue-specific modulation of galectin expression in lean and obese mice: evidence for regulatory function.
Obesity (Silver Spring, Md.)
Rhodes DH,Pini M,Castellanos KJ,Montero-Melendez T,Cooper D,Perretti M,Fantuzzi G
11-4801 was used in Flow cytometry/Cell sorting to evaluate the modulation of Gal-1, -3, -9 and -12 in visceral (VAT) and subcutaneous (SAT) adipose tissue in mice.
Fri Feb 01 00:00:00 EST 2013
Mycophenolic acid derivative 118 improves outcome of skin grafts by suppressing IL-17 production.
Acta pharmacologica Sinica
Kong FY,Chen W,He SJ,Lin ZM,Li X,Zhang XH,Yang XQ,Zhu FH,Tong XK,Zhou Y,Tang W,Duan WH,Zuo JP
11-4801 was used in Flow cytometry/Cell sorting to investigate the interaction between the mycophenolic acid derivative, 118, and the immune environment in a murine allogeneic skin graft model.
Mon Jul 01 00:00:00 EDT 2013
Traumatic brain injury induces macrophage subsets in the brain.
European journal of immunology
Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE
11-4801 was used in Flow cytometry/Cell sorting to better understand the mechanisms involved in the innate inflammatory responses to brain injury.
Thu Aug 01 00:00:00 EDT 2013
Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Frantz S,Hofmann U,Fraccarollo D,Schäfer A,Kranepuhl S,Hagedorn I,Nieswandt B,Nahrendorf M,Wagner H,Bayer B,Pachel C,Schön MP,Kneitz S,Bobinger T,Weidemann F,Ertl G,Bauersachs J
11-4801 was used in Flow cytometry/Cell sorting to show that impaired monocyte/macrophage function appears to be an unrecognized pathophysiological mechanism for left ventricular thrombus development after myocardial infarction.
Fri Mar 01 00:00:00 EST 2013
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.
Journal of immunology (Baltimore, Md. : 1950)
Yang X,Jiang X,Chen G,Xiao Y,Geng S,Kang C,Zhou T,Li Y,Guo X,Xiao H,Hou C,Wang R,Lin Z,Li X,Feng J,Ma Y,Shen B,Li Y,Han G
11-4801 was used in Flow cytometry/Cell sorting to demonstrate a regulatory role for Tim-3 as part of a novel protective mechanism in sepsis victims.
Fri Mar 01 00:00:00 EST 2013
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
11-4801 was used in Flow cytometry/Cell sorting to elucidate the role of LSECtin in pathogenesis of viral infection, showing that its absence led to increased frequency in intrahepatic CTLs, leading to accelerated liver adenovirus clearance.
Mon Apr 15 00:00:00 EDT 2013
Nerves and neovessels inhibit each other in the cornea.
Investigative ophthalmology & visual science
Ferrari G,Hajrasouliha AR,Sadrai Z,Ueno H,Chauhan SK,Dana R
11-4801 was used in Immunohistochemistry to evaluate the regulatory cross-talk of the vascular and neural networks in the cornea of mice.
Mon Jan 28 00:00:00 EST 2013
Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Van De Voort TJ,Felder MA,Yang RK,Sondel PM,Rakhmilevich AL
11-4801 was used in Flow cytometry/Cell sorting to assess the immunomodulatory and antitumour synergy between an agonistic anti-CD40 monoclonal antibody and monophosphoryl lipid A in mice.
Tue Jan 01 00:00:00 EST 2013
Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury.
American journal of physiology. Renal physiology
Huen SC,Moeckel GW,Cantley LG
11-4801 was used in Flow cytometry/Cell sorting to suggest that targeting macrophage-derived TGF-β1 is not an effective therapy for attenuating progressive renal fibrosis after kidney injury.
Thu Aug 15 00:00:00 EDT 2013
Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
PloS one
Wu X,Satpathy AT,Kc W,Liu P,Murphy TL,Murphy KM
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of Bcl11a in the development of dendritic cells, showing that it controls Flt3 expression in early hematopoietic progenitors and is required for pDC development.
Fri Jan 10 00:00:00 EST 2014
A novel probe for the non-invasive detection of tumor-associated inflammation.
Oncoimmunology
Balducci A,Wen Y,Zhang Y,Helfer BM,Hitchens TK,Meng WS,Wesa AK,Janjic JM
11-4801 was used in Flow cytometry/Cell sorting to develop a novel probe for the non-invasive detection of tumor-associated inflammation, with its feasibility demonstrated in a murine breast carcinoma model.
Fri Feb 01 00:00:00 EST 2013
Liver accumulation of Plasmodium chabaudi-infected red blood cells and modulation of regulatory T cell and dendritic cell responses.
PloS one
Medeiros MM,da Silva HB,Reis AS,Barboza R,Thompson J,Lima MR,Marinho CR,Tadokoro CE
11-4801 was used in Flow cytometry/Cell sorting to determine that malaria parasite accumulation could be an escape mechanism to avoid sterile immunity sponsored by a tolerogenic environment.
Wed Dec 17 00:00:00 EST 2014
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.
The Journal of biological chemistry
Jacobson LS,Lima H,Goldberg MF,Gocheva V,Tsiperson V,Sutterwala FS,Joyce JA,Gapp BV,Blomen VA,Chandran K,Brummelkamp TR,Diaz-Griffero F,Brojatsch J
11-4801 was used in Flow cytometry/Cell sorting to investigate how adjuvant-mediated necrotic cell death controls adjuvant-mediated immunity and how this may alter our design of more powerful, safer adjuvants.
Fri Mar 15 00:00:00 EDT 2013
Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.
PloS one
Luo F,Sun X,Wang Y,Wang Q,Wu Y,Pan Q,Fang C,Zhang XL
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of ficolin-2 during Mycobacterium tuberculosis infection.
Sun Jun 15 00:00:00 EDT 2014
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
American journal of clinical and experimental immunology
Noonan T,Lukas S,Peet GW,Pelletier J,Panzenbeck M,Hanidu A,Mazurek S,Wasti R,Rybina I,Roma T,Kronkaitis A,Shoultz A,Souza D,Jiang H,Nabozny G,Modis LK
11-4801 was used in Flow cytometry/Cell sorting to assess the relative contribution of the features of vascular adhesion protein-1 to its function.
Thu Jul 25 00:00:00 EDT 2013
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Immunity
Zeng X,Wei YL,Huang J,Newell EW,Yu H,Kidd BA,Kuhns MS,Waters RW,Davis MM,Weaver CT,Chien YH
11-4801 was used in Flow cytometry/Cell sorting to study the γδ T cell response to the algae protein, phycoerythrin.
Fri Sep 21 00:00:00 EDT 2012
Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice.
Circulation
Hofmann U,Beyersdorf N,Weirather J,Podolskaya A,Bauersachs J,Ertl G,Kerkau T,Frantz S
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of CD4+ T lymphocytes in wound healing after experimental myocardial infarction in mice.
Tue Apr 03 00:00:00 EDT 2012
Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis.
Circulation
Polykratis A,van Loo G,Xanthoulea S,Hellmich M,Pasparakis M
11-4801 was used in Flow cytometry/Cell sorting to study how toll-like receptor-mediated TRAF6 signaling acts in endothelial cells to promote atherosclerosis but displays atheroprotective, antiinflammatory and prosurvival functions in myeloid cells.
Tue Oct 02 00:00:00 EDT 2012
Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.
Blood
Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L
11-4801 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.
Thu May 10 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
11-4801 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
TNF-α mediates macrophage-induced bystander effects through Netrin-1.
Cancer research
Yang Y,Wang X,Moore DR,Lightfoot SA,Huycke MM
11-4801 was used in Immunohistochemistry to define a pathway for macrophage-induced bystander effects in which TNF-a triggers TNFRSF1b receptor signaling, thus increasing production of Netrin-1.
Mon Oct 15 00:00:00 EDT 2012
Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis.
Mucosal immunology
Müller U,Piehler D,Stenzel W,Köhler G,Frey O,Held J,Grahnert A,Richter T,Eschke M,Kamradt T,Brombacher F,Alber G
11-4801 was used in Flow cytometry/Cell sorting to study the function of the interleukin-4 receptor on T helper cells in pulmonary cryptococcosis.
Tue May 01 00:00:00 EDT 2012
A novel mouse model of Schistosoma haematobium egg-induced immunopathology.
PLoS pathogens
Fu CL,Odegaard JI,Herbert DR,Hsieh MH
11-4801 was used in Flow cytometry/Cell sorting to develop a better understanding of the unique pathophysiological mechanisms of epithelial dysfunction, tissue fibrosis, and onogenesis associated with urogenital schistomiasis.
Mon Jul 09 00:00:00 EDT 2012
Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.
The American journal of pathology
Ninković J,Roy S
11-4801 was used in Flow cytometry/Cell sorting to study how long-term morphine treatment can lead to attenuation of actin polymerisation, FcgR-mediated phagocytosis, and decreased bacterial clearance.
Thu Mar 01 00:00:00 EST 2012
Establishment and characterization of a sustained delayed-type hypersensitivity model with arthritic manifestations in C57BL/6J mice.
Arthritis research & therapy
Atkinson SM,Usher PA,Kvist PH,Markholst H,Haase C,Nansen A
11-4801 was used in Flow cytometry/Cell sorting to demonstrate that the DTH-arthritis model could hold potential in the preclinical screening of novel drugs targeting RA.
Thu Jun 07 00:00:00 EDT 2012
Involvement of periostin in regression of hyaloidvascular system during ocular development.
Investigative ophthalmology & visual science
Arima M,Yoshida S,Nakama T,Ishikawa K,Nakao S,Yoshimura T,Asato R,Sassa Y,Kita T,Enaida H,Oshima Y,Matsuda A,Kudo A,Ishibashi T
11-4801 was used in Immunohistochemistry on paraffin embedded tissues to suggest that periostin, which is secreted by the intraocular macrophages, enhances the HVS regression by intensifying the adhesion of macrophages to hyaloid vessels.
Fri Sep 21 00:00:00 EDT 2012
Optimized protocol for the isolation of spleen-resident murine neutrophils.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Coquery CM,Loo W,Buszko M,Lannigan J,Erickson LD
11-4801 was used in Flow cytometry/Cell sorting to develop a protocol to optimally isolate spleen-resistant murine neutrophils.
Sat Sep 01 00:00:00 EDT 2012
Optimized protocol for the isolation of spleen-resident murine neutrophils.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Coquery CM,Loo W,Buszko M,Lannigan J,Erickson LD
11-4801 was used in Flow cytometry/Cell sorting to develop a protocol to optimally isolate spleen-resistant murine neutrophils.
Sat Sep 01 00:00:00 EDT 2012
Nocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in BALB/c mice.
Infection and immunity
Trevino-Villarreal JH,Vera-Cabrera L,Valero-Guillén PL,Salinas-Carmona MC
11-4801 was used in Flow cytometry/Cell sorting to investigate the parthenogenesis of Nocardia brasiliensis infection, showing that N.brasiliensis cell wall lipids modulate macrophage and dendritic responses, leading to actinomycetoma.
Mon Oct 01 00:00:00 EDT 2012
Comparison of blood monocytes and adipose tissue macrophages in a mouse model diet-induced weight gain.
Comparative medicine
McFarlin BK,Carpenter KC,Strohacker K,Breslin WL
11-4801 was used in Flow cytometry/Cell sorting to compare blood monocytes and adipose tissue macrophages in diet-induced weight gain in mice.
Sat Dec 01 00:00:00 EST 2012
Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.
PloS one
Menning A,Walter A,Rudolph M,Gashaw I,Fritzemeier KH,Roese L
11-4801 was used in Flow cytometry/Cell sorting to investigate mechanisms underlying pathogenesis of menstrual disorders, showing that granulocytes and vascularisation regulate uterine bleeding and tissue remodelling.
Thu Jan 10 00:00:00 EST 2013
Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling.
Malaria journal
Fu Y,Ding Y,Zhou T,Fu X,Xu W
11-4801 was used in Flow cytometry/Cell sorting to study the immune response following infection of a lethal or non-lethal strain of rodent malaria parasites.
Sun Apr 01 00:00:00 EDT 2012
Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells.
Immunity
Ma G,Pan PY,Eisenstein S,Divino CM,Lowell CA,Takai T,Chen SH
11-4801 was used in Immunofluorescence to examine the role of paired immunoglobulin-like receptor B (PIR-B) in tumour-induced immunity.
Fri Mar 25 00:00:00 EDT 2011
Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.
Blood
Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA
11-4801 was used in Flow cytometry/Cell sorting to reveal a molecular mechanism by which chronic exposure to IFN-γ induces expression of IRF-1 and ultimately induces anaemia.
Thu Sep 01 00:00:00 EDT 2011
Distinct macrophage phenotypes contribute to kidney injury and repair.
Journal of the American Society of Nephrology : JASN
Lee S,Huen S,Nishio H,Nishio S,Lee HK,Choi BS,Ruhrberg C,Cantley LG
11-4801 was used in Immunofluorescence on frozen tissues to investigate the role of macrophages in ischemic kidney injury, showing that distinct macrophage phenotypes contribute to kidney injury and repair.
Tue Feb 01 00:00:00 EST 2011
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology
Buhtoiarov IN,Sondel PM,Wigginton JM,Buhtoiarova TN,Yanke EM,Mahvi DA,Rakhmilevich AL
11-4801 was used in Flow cytometry/Cell sorting to show that chemotherapy and anti-CD40 + CpG-ODN IT synergise in the induction of anti-tumour effects which are associated with the phenotypic repolarisation of tumour-associated Mφ.
Tue Feb 01 00:00:00 EST 2011
The tumor suppressor ARF regulates innate immune responses in mice.
Journal of immunology (Baltimore, Md. : 1950)
Través PG,López-Fontal R,Luque A,Hortelano S
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of the tumour suppressor alternative reading frame (ARF) in the regulation of innate immunity in mice.
Thu Dec 15 00:00:00 EST 2011
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Xu W,Xiong S
11-4801 was used in Flow cytometry/Cell sorting to discover a mechanism responsible for modulation of macrophage polarization in lupus nephritis, opening a potential therapeutic avenue for SLE.
Mon Aug 15 00:00:00 EDT 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
11-4801 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.
Thu Dec 15 00:00:00 EST 2011
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G
11-4801 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.
Sun May 01 00:00:00 EDT 2011
Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration.
Journal of cellular and molecular medicine
Carmona R,Cano E,Grueso E,Ruiz-Villalba A,Bera TK,Gaztambide J,Segovia JC,Muñoz-Chápuli R
11-4801 was used in Flow cytometry/Cell sorting to show that peritoneal regeneration involves the recruitment of bone marrow derived cells which display expression of mesothelial markers (particularly mesothelin), and adhere to the damaged surfaces.
Sun May 01 00:00:00 EDT 2011
Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.
Infection and immunity
Frazer LC,O'Connell CM,Andrews CW,Zurenski MA,Darville T
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of neutrophils in chlamydia-induced pathology.
Sat Oct 01 00:00:00 EDT 2011
CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.
The Journal of experimental medicine
Zhou J,Tang PC,Qin L,Gayed PM,Li W,Skokos EA,Kyriakides TR,Pober JS,Tellides G
11-4801 was used in Immunofluorescence to reveal a CXCR3-dependent accumulation and activation of perivascular macrophages as a necessary step in homeostatic arterial remodeling triggered by hemodynamic stress in mice and possibly in humans as well.
Mon Aug 30 00:00:00 EDT 2010
17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Calippe B,Douin-Echinard V,Delpy L,Laffargue M,Lélu K,Krust A,Pipy B,Bayard F,Arnal JF,Guéry JC,Gourdy P
11-4801 was used in Flow cytometry/Cell sorting to investigate the effect of 17β-estradiol on macrophage effector functions under inflammatory conditions in vivo.
Thu Jul 15 00:00:00 EDT 2010
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
11-4801 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 EST 2010
CD40 expression levels modulate regulatory T cells in Leishmania donovani infection.
Journal of immunology (Baltimore, Md. : 1950)
Martin S,Agarwal R,Murugaiyan G,Saha B
11-4801 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell-expressed CD40 in the generation of Tregs.
Thu Jul 01 00:00:00 EDT 2010
IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.
International immunology
Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN
11-4801 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.
Thu Apr 01 00:00:00 EDT 2010
CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.
Infection and immunity
Eppert BL,Motz GT,Wortham BW,Flury JL,Borchers MT
11-4801 was used in Flow cytometry/Cell sorting to investigate the roles of CCR7 in the host defense against pulmonary infection, showing that CCR7 deficiency leads to leukocyte activation and increased infection clearance.
Sat May 01 00:00:00 EDT 2010
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
11-4801 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Type I interferon modulates monocyte recruitment and maturation in chronic inflammation.
The American journal of pathology
Lee PY,Li Y,Kumagai Y,Xu Y,Weinstein JS,Kellner ES,Nacionales DC,Butfiloski EJ,van Rooijen N,Akira S,Sobel ES,Satoh M,Reeves WH
11-4801 was used in Flow cytometry/Cell sorting to define the mechanisms underlying the sustained influx of monocytes observable during chronic inflammation.
Sun Nov 01 00:00:00 EDT 2009
Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching.
International immunology
Matheson LS,Osborn MJ,Smith JA,Corcos D,Hamon M,Chaouaf R,Coadwell J,Morgan G,Oxley D,Brüggemann M
11-4801 was used in Flow cytometry/Cell sorting to study the novel class of heavy-chain immunoglobulin with covalently linked alpha chains produced in light-chain deficient mice.
Sat Aug 01 00:00:00 EDT 2009
Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblasts.
Endocrinology
Wittrant Y,Gorin Y,Mohan S,Wagner B,Abboud-Werner SL
11-4801 was used in Flow cytometry/Cell sorting to provide evidence that osteoblasts express colony-stimulating factor-1 (CSF-1) receptor and are a target for CSF-1 ligand.
Sun Nov 01 00:00:00 EDT 2009
Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis.
Immunity
Tsujimura Y,Obata K,Mukai K,Shindou H,Yoshida M,Nishikado H,Kawano Y,Minegishi Y,Shimizu T,Karasuyama H
11-4801 was used in Flow cytometry/Cell sorting to highlight a pivotal role for basophils in vivo and contrast two major, distinct pathways leading to allergen-induced systemic anaphylaxis.
Tue Apr 01 00:00:00 EDT 2008
cAMP modulates macrophage development by suppressing M-CSF-induced MAPKs activation.
Cellular & molecular immunology
Zhu N,Cui J,Qiao C,Li Y,Ma Y,Zhang J,Shen B
11-4801 was used in Flow cytometry/Cell sorting to explore the effects of cAMP on macrophage development using a model of bone marrow-derived murine macrophages.
Tue Apr 01 00:00:00 EDT 2008
Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS.
Glia
de Haas AH,Boddeke HW,Biber K
11-4801 was used in Flow cytometry/Cell sorting to evaluate the existence of distinct microglia phenotypes in various regions of the healthy, adult mouse central nervous system.
Sun Jun 01 00:00:00 EDT 2008
Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation.
Journal of virology
Lacasse P,Denis J,Lapointe R,Leclerc D,Lamarre A
11-4801 was used in Flow cytometry/Cell sorting to demonstrate the efficiency of a plant virus-based vaccination platform in inducing DC maturation leading to protective CTL responses.
Tue Jan 01 00:00:00 EST 2008
Enhancement by tumor necrosis factor alpha of dengue virus-induced endothelial cell production of reactive nitrogen and oxygen species is key to hemorrhage development.
Journal of virology
Yen YT,Chen HC,Lin YD,Shieh CC,Wu-Hsieh BA
11-4801 was used in Immunofluorescence to show that dengue virus actively infects the endothelium at 12 h and 24 h after inoculation.
Mon Dec 01 00:00:00 EST 2008
Role of interferon in homologous and heterologous rotavirus infection in the intestines and extraintestinal organs of suckling mice.
Journal of virology
Feng N,Kim B,Fenaux M,Nguyen H,Vo P,Omary MB,Greenberg HB
11-4801 was used in Immunohistochemistry to indicate that interferon system inhibition of intestinal and extraintestinal viral replication in suckling mice varies between heterologous and homologous rotavirus strains.
Fri Aug 01 00:00:00 EDT 2008
Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling.
Journal of virology
Purtha WE,Chachu KA,Virgin HW,Diamond MS
11-4801 was used in Flow cytometry/Cell sorting to suggest that early B-cell activation after WNV infection is immunoglobulin receptor and macrophage independent, and requires signalling through the type 1 IFN-alpha/beta receptor.
Sat Nov 01 00:00:00 EDT 2008
Macrophages express multiple ligands for gammadelta TCRs.
Molecular immunology
Aydintug MK,Roark CL,Chain JL,Born WK,O'Brien RL
11-4801 was used in Flow cytometry/Cell sorting to detect and track the ligands of of two gammadelta T cell subsets common in the mouse using soluble multimerised gammadelta T cell receptors.
Sun Jun 01 00:00:00 EDT 2008
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology
Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ
Sat Oct 01 00:00:00 EDT 2005
