Product References
Transcriptional reprogramming of skeletal muscle stem cells by the niche environment.
Nature communications
Lazure F,Farouni R,Sahinyan K,Blackburn DM,Hernández-Corchado A,Perron G,Lu T,Osakwe A,Ragoussis J,Crist C,Perkins TJ,Jahani-Asl A,Najafabadi HS,Soleimani VD
12-4801-82 was used in Flow cytometry/Cell sorting to show that aging leads to a significant transcriptomic shift in their subpopulations accompanied by locus-specific gain and loss of chromatin accessibility and DNA methylation.
Wed Feb 01 00:00:00 EST 2023
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.
Nature
Pernet E,Sun S,Sarden N,Gona S,Nguyen A,Khan N,Mawhinney M,Tran KA,Chronopoulos J,Amberkar D,Sadeghi M,Grant A,Wali S,Prevel R,Ding J,Martin JG,Thanabalasuriar A,Yipp BG,Barreiro LB,Divangahi M
12-4801-82 was used in Flow cytometry/Cell sorting to highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal.
Wed Feb 01 00:00:00 EST 2023
Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression.
Signal transduction and targeted therapy
Liu Y,Shao YH,Zhang JM,Wang Y,Zhou M,Li HQ,Zhang CC,Yu PJ,Gao SJ,Wang XR,Jia LX,Piao CM,Du J,Li YL
12-4801-82 was used in Flow Cytometry to demonstrate that macrophage CARD9 mediates the deterioration of cardiac function and adverse remodeling post-MI via LCN2.
Fri Oct 13 00:00:00 EDT 2023
The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation.
The Journal of biological chemistry
Podolnikova NP,Key S,Wang X,Ugarova TP
12-4801-82 was used in Functional Assay to indicate that Mac-1 forms a lateral complex with CD47, which regulates essential macrophage functions by stabilizing the extended integrin conformation.
Sat Apr 01 00:00:00 EDT 2023
Intravenous Transplantation of an Ischemic-specific Peptide-TPP-mitochondrial Compound Alleviates Myocardial Ischemic Reperfusion Injury.
ACS nano
Sun X,Chen H,Gao R,Qu Y,Huang Y,Zhang N,Hu S,Fan F,Zou Y,Hu K,Chen Z,Ge J,Sun A
12-4801-82 was used in Flow cytometry/Cell sorting to provide promising evidence that the PEP-TPP-mitochondrial compound effectively promotes intravenous mitochondrial transplantation into the ischemic myocardium and subsequently ameliorates myocardial ischemia-reperfusion injury.
Tue Jan 10 00:00:00 EST 2023
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma.
Frontiers in pharmacology
Zhang W,Jiang X,Zou Y,Yuan L,Wang X
12-4801-82 was used in Flow Cytometry to show that the combination of pexidartinib and PD-1 antibody showed a synergy and significantly improved the anti-tumor efficacy, through pexidartinib increasing CD8T/Treg ratio by reducing TAM-derived CCL22.
Tue Mar 28 00:00:00 EDT 2023
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
12-4801-82 was used in Flow Cytometry to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.
Mon Jan 24 00:00:00 EST 2022
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
12-4801-82 was used in Flow Cytometry to establish a tumor-suppressive function of WHSC1 that relays IFN-γ signaling to promote antigen presentation in CRC cells, and provide a rationale for boosting WHSC1 activity in immunotherapy.
Fri Apr 15 00:00:00 EDT 2022
Targeting Fc Receptor-Mediated Effects and the "Don't Eat Me" Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Tian L,Xu B,Teng KY,Song M,Zhu Z,Chen Y,Wang J,Zhang J,Feng M,Kaur B,Rodriguez L,Caligiuri MA,Yu J
12-4801-82 was used in Flow cytometry/Cell sorting to improve therapeutic efficacy while reducing toxicities for ovarian cancer.
Sat Jan 01 00:00:00 EST 2022
Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity.
Oncogene
Zhang T,Wang Y,Li Q,Lin L,Xu C,Xue Y,Hu M,Shi Y,Wang Y
12-4801-82 was used in Flow Cytometry to conclude that IFNα-MSCs represent a novel tumor immunotherapy strategy, especially when combined with PD-L1 blockade.
Tue Mar 01 00:00:00 EST 2022
Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties.
Oncoimmunology
Sommer A,Berndt S,Lerchen HG,Forveille S,Sauvat A,Mumberg D,Kroemer G,Kepp O
12-4801-82 was used in Flow Cytometry to conclude that the antineoplastic effects of TWEAKR-KSPi-ADCs can partly be attributed to its ICD-stimulatory properties.
Fri Apr 08 00:00:00 EDT 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
12-4801-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
12-4801-82 was used in flow cytometry to assess this concept by combining vascular endothelial growth factor (VEGF) pathway inhibitors that remodel the tumor vasculature with the tricyclic antidepressant imipramine, which enhances autophagy in GBM cancer cells and unexpectedly reprograms immunosuppressive tumor-associated macrophages via inhibition of histamine receptor signaling to become immunostimulatory.
Mon Oct 10 00:00:00 EDT 2022
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.
Cell reports
Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ
12-4801-82 was used in Flow Cytometry to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.
Tue Jan 25 00:00:00 EST 2022
Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage-Myofibroblast Transition.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Tang PC,Chung JY,Xue VW,Xiao J,Meng XM,Huang XR,Zhou S,Chan AS,Tsang AC,Cheng AS,Lee TL,Leung KT,Lam EW,To KF,Tang PM,Lan HY
12-4801-82 was used in Immunocytochemistry-immunoflourescence to conclude that MMT may represent a novel therapeutic target of CAF for cancer immunotherapy.
Sat Jan 01 00:00:00 EST 2022
Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy.
Immunity
Denk D,Petrocelli V,Conche C,Drachsler M,Ziegler PK,Braun A,Kress A,Nicolas AM,Mohs K,Becker C,Neurath MF,Farin HF,Buchholz CJ,Andreux PA,Rinsch C,Greten FR
12-4801-82 was used in Sample Preparation to unravel a critical signaling pathway linking mitophagy to T memory stem cell formation and suggest that the metabolic compound Urolithin A represents an option to improve immune therapy.
Tue Nov 08 00:00:00 EST 2022
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Auyeung VC,Downey MS,Thamsen M,Wenger TA,Backes BJ,Sheppard D,Papa FR
12-4801-82 was used in Flow cytometry/Cell sorting to show that the bifunctional kinase/RNase-IRE1α-a central mediator of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress is a critical promoter of DATP abundance and function.
Fri Apr 01 00:00:00 EDT 2022
Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.
Frontiers in immunology
Wong SW,McCarroll J,Hsu K,Geczy CL,Tedla N
12-4801-82 was used in Flow cytometry/Cell sorting to indicate that treatment with S100A8 may favourably modify the lung microenvironment to promote an effective immune response in lungs, thereby representing a new strategy that could complement current immunotherapies in lung cancer.
Mon Jun 06 00:00:00 EDT 2022
Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
Cellular and molecular gastroenterology and hepatology
Hong CH,Ko MS,Kim JH,Cho H,Lee CH,Yoon JE,Yun JY,Baek IJ,Jang JE,Lee SE,Cho YK,Baek JY,Oh SJ,Lee BY,Lim JS,Lee J,Hartig SM,Conde de la Rosa L,Garcia-Ruiz C,Lee KU,Fernández-Checa JC,Choi JW,Kim S,Koh EH
12-4801-82 was used in Flow Cytometry to show that S1PR4 may be a new therapeutic target for NASH that mediates the activation of NLRP3 inflammasome in hepatic macrophages.
Mon Apr 04 00:00:00 EDT 2022
Combination of a STAT3 inhibitor with anti-PD-1 immunotherapy is an effective treatment regimen for a vemurafenib-resistant melanoma.
Molecular therapy oncolytics
Kim TW,Kim Y,Keum H,Jung W,Kang M,Jon S
12-4801-82 was used in Flow cytometry/Cell sorting to investigate the antitumor efficacy and TME remodeling by APTSTAT3-9R, a cell-permeable STAT3 inhibitory peptide, as a strategy to treat vemurafenib-resistant melanoma.
Thu Sep 15 00:00:00 EDT 2022
miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America
Ma C,He D,Tian P,Wang Y,He Y,Wu Q,Jia Z,Zhang X,Zhang P,Ying H,Jin ZB,Hu G
12-4801-82 was used in Flow Cytometry to reveal a crucial TGFβ/miR-182/TLR4 axis for TAM polarization and provide rationale for RNA-based therapeutics of TAM targeting in cancer.
Tue Feb 08 00:00:00 EST 2022
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.
Cell death & disease
Del Rio Oliva M,Basler M
12-4801-82 was used in Flow Cytometry to evaluate the effect of CB-5083 on the immune response in mice by using the lymphocytic choriomeningitis virus (LCMV) as an infection model.
Thu Dec 01 00:00:00 EST 2022
Skin inflammation activates intestinal stromal fibroblasts and promotes colitis.
The Journal of clinical investigation
Dokoshi T,Seidman JS,Cavagnero KJ,Li F,Liggins MC,Taylor BC,Olvera J,Knight R,Chang JT,Salzman NH,Gallo RL
12-4801-82 was used in Flow Cytometry to understand whether fibroblasts participate in the pathogenesis of inflammatory bowel diseases and if hyaluronan could act as a signal from the skin to alter intestinal immune function through effects on fat cell differentiation.
Mon Nov 01 00:00:00 EDT 2021
TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis.
The Journal of clinical investigation
Hou J,Zhang J,Cui P,Zhou Y,Liu C,Wu X,Ji Y,Wang S,Cheng B,Ye H,Shu L,Zhang K,Wang D,Xu J,Shu Q,Colonna M,Fang X
12-4801-82 was used in Flow Cytometry to discover a metabolic coordination between hepatocyte mitochondria and liver macrophages that express triggering receptor expressed on myeloid cells-2 (TREM2).
Mon Feb 15 00:00:00 EST 2021
The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection.
The Journal of clinical investigation
Arnardottir H,Thul S,Pawelzik SC,Karadimou G,Artiach G,Gallina AL,Mysdotter V,Carracedo M,Tarnawski L,Caravaca AS,Baumgartner R,Ketelhuth DF,Olofsson PS,Paulsson-Berne G,Hansson GK,Bäck M
12-4801-82 was used in Flow cytometry/Cell sorting to provide evidence that GPR32 regulates resolution of inflammation and is atheroprotective in vivo.
Wed Dec 15 00:00:00 EST 2021
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway.
The Journal of experimental medicine
Wu T,Liu Q,Li Y,Li H,Chen L,Yang X,Tang Q,Pu S,Kuang J,Li R,Huang Y,Zhang J,Zhang Z,Zhou J,Huang C,Zhang G,Zhao Y,Zou M,Jiang W,Mo L,He J
12-4801 was used in Flow cytometry/Cell sorting to identify that mesencephalic astrocyte-derived neurotrophic factor (Manf) is a feeding-induced hepatokine.
Mon Jun 07 00:00:00 EDT 2021
Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases.
Bone research
Polavaram NS,Dutta S,Islam R,Bag AK,Roy S,Poitz D,Karnes J,Hofbauer LC,Kohli M,Costello BA,Jimenez R,Batra SK,Teply BA,Muders MH,Datta K
12-4801 was used in Flow cytometry/Cell sorting to indicate that targeting NRP2 in prostate cancer cells as well as in the osteoclastic compartment can be beneficial in the treatment of prostate cancer bone metastasis.
Fri May 14 00:00:00 EDT 2021
β-asarone suppresses HCT116 colon cancer cell proliferation and liver metastasis in part by activating the innate immune system.
Oncology letters
Chen M,Zhuang YW,Wu CE,Peng HY,Qian J,Zhou JY
12-4801-82 was used in Flow Cytometry to determine the antineoplastic effect of β-asarone in HCT116 colon cancer cells, either in vitro or in vivo.
Tue Jun 01 00:00:00 EDT 2021
Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice.
Dose-response : a publication of International Hormesis Society
Rey N,Ebrahimian T,Gloaguen C,Kereselidze D,Magneron V,Bontemps CA,Demarquay C,Olsson G,Haghdoost S,Lehoux S,Ebrahimian TG
12-4801-82 was used in Flow Cytometry to investigate the immunomodulatory response of different doses and dose-rates of irradiation in ApoE-/- mice.
Fri Jun 25 00:00:00 EDT 2021
Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury.
Nature communications
Honda M,Kadohisa M,Yoshii D,Komohara Y,Hibi T
12-4801-82 was used in flow cytometry experiments to show, using spinning-disk confocal microscopy, that large F4/80hiGATA6+ peritoneal cavity macrophages promptly accumulate at damaged intestinal sites upon intestinal thermal injury and upon dextran sodium sulfate induced colitis in mice via a direct route from the peritoneal cavity.
Wed Dec 15 00:00:00 EST 2021
Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis.
Scientific reports
Cai C,Zeng D,Gao Q,Ma L,Zeng B,Zhou Y,Wang H
12-4801-82 was used in Flow Cytometry to demonstrate if downregulated ferroportin expression in hepatocytes can promote the proliferation and polarization of macrophages, leading to hepatic fibrosis.
Mon Jun 28 00:00:00 EDT 2021
Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis.
Scientific reports
Cai C,Zeng D,Gao Q,Ma L,Zeng B,Zhou Y,Wang H
12-4801-82 was used in Flow Cytometry to demonstrate if downregulated ferroportin expression in hepatocytes can promote the proliferation and polarization of macrophages, leading to hepatic fibrosis.
Mon Jun 28 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
12-4801-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma.
Nature communications
Xu B,Tian L,Chen J,Wang J,Ma R,Dong W,Li A,Zhang J,Antonio Chiocca E,Kaur B,Feng M,Caligiuri MA,Yu J
12-4801-82 was used in Flow cytometry/Cell sorting to show locoregional control of glioblastoma by an oncolytic herpes virus expressing a full-length anti(α)-human CD47 IgG1 or IgG4 antibody.
Fri Oct 08 00:00:00 EDT 2021
Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.
eLife
Shan Z,Li L,Atkins CL,Wang M,Wen Y,Jeong J,Moreno NF,Feng D,Gui X,Zhang N,Lee CG,Elias JA,Lee WM,Gao B,Lam FW,An Z,Ju C
12-4801-82 was used in Flow Cytometry to unveil a critical role of Chi3l1 in hepatic platelet recruitment during AILI.
Thu Jun 10 00:00:00 EDT 2021
Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.
International journal of molecular sciences
Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI
12-4801-82 was used in Flow Cytometry to suggest butyrate as an SSc treatment.
Tue Mar 09 00:00:00 EST 2021
Roles of lung-recruited monocytes and pulmonary Vascular Endothelial Growth Factor (VEGF) in resolving Ventilator-Induced Lung Injury (VILI).
PloS one
Lin CK,Huang TH,Yang CT,Shi CS
12-4801 was used in Flow cytometry/Cell sorting to identify the phenotypes of monocytes recruited to the lungs during the resolution of VILI and investigated the contributions of monocytes and VEGF to lung repair.
Tue Oct 12 00:00:00 EDT 2021
EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis.
eLife
Mukherjee K,Xue L,Planutis A,Gnanapragasam MN,Chess A,Bieker JJ
12-4801-82 was used in Flow Cytometry to find that fetal liver macrophages exhibit a unique expression signature that differentiates them from erythroid and adult macrophage cells.
Thu Feb 11 00:00:00 EST 2021
CD226 knockout alleviates high-fat diet induced obesity by suppressing proinflammatory macrophage phenotype.
Journal of translational medicine
Ma J,Hu W,Zhang D,Xie J,Duan C,Liu Y,Wang Y,Xu X,Cheng K,Jin B,Zhang Y,Zhuang R
12-4801-82 was used in Immunocytochemistry to show that the costimulatory molecule CD226 was highly expressed on adipose tissue macrophages and knockout of CD226 alleviated obesity caused by high-fat diet.
Thu Nov 25 00:00:00 EST 2021
Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection.
Cell host & microbe
Pham THM,Brewer SM,Thurston T,Massis LM,Honeycutt J,Lugo K,Jacobson AR,Vilches-Moure JG,Hamblin M,Helaine S,Monack DM
12-4801 was used in Flow cytometry/Cell sorting to elucidate a host-pathogen interaction that controls granuloma macrophage polarization and long-term pathogen persistence during Salmonella Typhimurium (STm) infection.
Wed Jan 08 00:00:00 EST 2020
Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation.
The Journal of clinical investigation
McArthur S,Juban G,Gobbetti T,Desgeorges T,Theret M,Gondin J,Toller-Kawahisa JE,Reutelingsperger CP,Chazaud B,Perretti M,Mounier R
12-4801 was used in Flow cytometry/Cell sorting to explore the role of Annexin A1 in skeletal muscle injury regeneration.
Mon Mar 02 00:00:00 EST 2020
YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction.
PLoS biology
Mia MM,Cibi DM,Abdul Ghani SAB,Song W,Tee N,Ghosh S,Mao J,Olson EN,Singh MK
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that expression of YAP and TAZ is increased in macrophages undergoing pro-inflammatory or reparative phenotype changes.
Tue Dec 01 00:00:00 EST 2020
GRP94 regulates M1 macrophage polarization and insulin resistance.
American journal of physiology. Endocrinology and metabolism
Song L,Kim DS,Gou W,Wang J,Wang P,Wei Z,Liu B,Li Z,Gou K,Wang H
12-4801-82 was used in Flow Cytometry to elucidate the mechanism of glucose-regulated protein 94 in insulin resistance and inflammation.
Mon Jun 01 00:00:00 EDT 2020
Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.
The American journal of pathology
Stahl EC,Delgado ER,Alencastro F,LoPresti ST,Wilkinson PD,Roy N,Haschak MJ,Skillen CD,Monga SP,Duncan AW,Brown BN
12-4801-82 was used in Flow Cytometry to perform a comprehensive study of lipid content and inflammatory signature of livers in 19-month-old aged female mice.
Sat Feb 01 00:00:00 EST 2020
A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity.
Frontiers in oncology
Rios-Doria J,Favata M,Lasky K,Feldman P,Lo Y,Yang G,Stevens C,Wen X,Sehra S,Katiyar K,Liu K,Wynn R,Harris JJ,Ye M,Spitz S,Wang X,He C,Li YL,Yao W,Covington M,Scherle P,Koblish H
12-4801-82 was used in Flow Cytometry to support the potential therapeutic utility of INCB081776 as an immunotherapeutic agent capable of both enhancing tumor immune surveillance and blocking tumor cell survival mechanisms.
Tue Jan 12 00:00:00 EST 2021
Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.
American journal of physiology. Gastrointestinal and liver physiology
Okamura T,Hamaguchi M,Bamba R,Nakajima H,Yoshimura Y,Kimura T,Nishida K,Hashimoto Y,Fukuda T,Senmaru T,Fukui M
12-4801-82 was used in Flow cytometry/Cell sorting to suggest that a combination of estrogen and testosterone may be clinically relevant for the treatment of NAFLD in patients with male menopause.
Mon Jun 01 00:00:00 EDT 2020
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway.
OncoTargets and therapy
Zhou B,Li C,Yang Y,Wang Z
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that overexpression of RIG-I promoted apoptosis and death of HCC cells.
Sun Apr 17 00:00:00 EDT 2022
Uncoupling protein-2 regulates M1 macrophage infiltration of gingiva with periodontitis.
Central-European journal of immunology
Yan X,Yuan Z,Bian Y,Jin L,Mao Z,Lei J,Chen N
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that the expression of UCP2 was upregulated in M1 macrophages infiltrating human periodontal tissues with periodontitis.
Mon Sep 28 00:00:00 EDT 2020
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints.
Nature communications
Kong YW,Dreaden EC,Morandell S,Zhou W,Dhara SS,Sriram G,Lam FC,Patterson JC,Quadir M,Dinh A,Shopsowitz KE,Varmeh S,Yilmaz ÖH,Lippard SJ,Reinhardt HC,Hemann MT,Hammond PT,Yaffe MB
12-4801 was used in Flow cytometry/Cell sorting to describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhances a pre-existing synthetic lethal combination.
Mon Aug 17 00:00:00 EDT 2020
IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A+Foxp3+ Cells During Mucosal Infection and Is Dysregulated With Aging.
Frontiers in immunology
Bhaskaran N,Faddoul F,Paes da Silva A,Jayaraman S,Schneider E,Mamileti P,Weinberg A,Pandiyan P
12-4801-82 was used in Flow Cytometry to identify IL-1β/MyD88/Treg axis as a new component that modulates inflammatory responses in oral mucosa.
Mon Jun 28 00:00:00 EDT 2021
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
12-4801 was used in Flow cytometry/Cell sorting to investigate the therapeutic effect of two commercial multispecies probiotics-Lactibiane iki and Vivomixx-on the clinical outcome of established experimental autoimmune encephalomyelitis (EAE).
Tue Apr 07 00:00:00 EDT 2020
TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Cell reports
Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP
12-4801 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.
Tue Apr 07 00:00:00 EDT 2020
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Nature communications
Lang J,Bohn P,Bhat H,Jastrow H,Walkenfort B,Cansiz F,Fink J,Bauer M,Olszewski D,Ramos-Nascimento A,Duhan V,Friedrich SK,Becker KA,Krawczyk A,Edwards MJ,Burchert A,Huber M,Friebus-Kardash J,Göthert JR,Hardt C,Probst HC,Schumacher F,Köhrer K,Kleuser B,Babiychuk EB,Sodeik B,Seibel J,Greber UF,Lang PA,Gulbins E,Lang KS
12-4801-82 was used in Immunohistochemistry to show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs).
Thu Mar 12 00:00:00 EDT 2020
The miR-183/96/182 Cluster Regulates the Functions of Corneal Resident Macrophages.
ImmunoHorizons
Coku A,McClellan SA,Van Buren E,Back JB,Hazlett LD,Xu S
12-4801-82 was used in Flow Cytometry to provide direct evidence that the mouse corneal ResMφ constitutively produce both IL-17f and IL-10.
Wed Nov 18 00:00:00 EST 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
12-4801 was used in Flow cytometry/Cell sorting to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.
Tue Jan 14 00:00:00 EST 2020
Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity.
Cell reports
Zhivaki D,Borriello F,Chow OA,Doran B,Fleming I,Theisen DJ,Pallis P,Shalek AK,Sokol CL,Zanoni I,Kagan JC
12-4801 was used in Flow cytometry/Cell sorting to study how hyperactivating stimuli can induce CTL-mediated anti-tumor immunity against tumors that are both sensitive and resistant to PD-1 inhibitior.
Tue Nov 17 00:00:00 EST 2020
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
Nature communications
Yamamuro T,Kawabata T,Fukuhara A,Saita S,Nakamura S,Takeshita H,Fujiwara M,Enokidani Y,Yoshida G,Tabata K,Hamasaki M,Kuma A,Yamamoto K,Shimomura I,Yoshimori T
12-4801 was used in Flow cytometry/Cell sorting to propose that age-dependent decline in adipose Rubicon exacerbates metabolic disorders by promoting excess autophagic degradation of SRC-1 and TIF2.
Tue Aug 18 00:00:00 EDT 2020
Dendritic Cells and Myeloid Derived Suppressor Cells Fully Responsive to Stimulation via Toll-Like Receptor 4 Are Rapidly Induced from Bone-Marrow Cells by Granulocyte-Macrophage Colony-Stimulating Factor.
Vaccines
Kong YY,Wilson K,Apostolopoulos V,Plebanski M
12-4801 was used in Flow cytometry/Cell sorting to unveiled the role for the rapid initiation of productive immunity by GM-CSF.
Sat Sep 12 00:00:00 EDT 2020
Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis.
Immunity
Deniset JF,Belke D,Lee WY,Jorch SK,Deppermann C,Hassanabad AF,Turnbull JD,Teng G,Rozich I,Hudspeth K,Kanno Y,Brooks SR,Hadjantonakis AK,O'Shea JJ,Weber GF,Fedak PWM,Kubes P
12-4801 was used in Flow cytometry/Cell sorting to find that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling.
Tue Jul 16 00:00:00 EDT 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
12-4801 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response.
Nature cell biology
Salvagno C,Ciampricotti M,Tuit S,Hau CS,van Weverwijk A,Coffelt SB,Kersten K,Vrijland K,Kos K,Ulas T,Song JY,Ooi CH,Rüttinger D,Cassier PA,Jonkers J,Schultze JL,Ries CH,de Visser KE
12-4801-82 was used in Flow Cytometry to investigate the mechanisms underlying the therapeutic benefit of myeloid-targeting agents in combination with chemotherapy.
Mon Apr 01 00:00:00 EDT 2019
MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα.
Cellular & molecular immunology
Jaiswal A,Reddy SS,Maurya M,Maurya P,Barthwal MK
12-4801 was used in Flow cytometry/Cell sorting to study the influence of miR-99a on macrophage phenotype and tissue inflammation.
Wed May 01 00:00:00 EDT 2019
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.
Brain, behavior, and immunity
Fonseca RC,Bassi GS,Brito CC,Rosa LB,David BA,Araújo AM,Nóbrega N,Diniz AB,Jesus ICG,Barcelos LS,Fontes MAP,Bonaventura D,Kanashiro A,Cunha TM,Guatimosim S,Cardoso VN,Fernandes SOA,Menezes GB,de Lartigue G,Oliveira AG
12-4801-82 was used in Immunohistochemistry, Flow Cytometry to provide new insights into the neural regulation of the immune system in the liver.
Tue Oct 01 00:00:00 EDT 2019
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver.
Brain, behavior, and immunity
Fonseca RC,Bassi GS,Brito CC,Rosa LB,David BA,Araújo AM,Nóbrega N,Diniz AB,Jesus ICG,Barcelos LS,Fontes MAP,Bonaventura D,Kanashiro A,Cunha TM,Guatimosim S,Cardoso VN,Fernandes SOA,Menezes GB,de Lartigue G,Oliveira AG
12-4801-82 was used in Immunohistochemistry, Flow Cytometry to provide new insights into the neural regulation of the immune system in the liver.
Tue Oct 01 00:00:00 EDT 2019
Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion.
Cancer research
Li F,Kitajima S,Kohno S,Yoshida A,Tange S,Sasaki S,Okada N,Nishimoto Y,Muranaka H,Nagatani N,Suzuki M,Masuda S,Thai TC,Nishiuchi T,Tanaka T,Barbie DA,Mukaida N,Takahashi C
12-4801 was used in Flow cytometry/Cell sorting to show that inactivation of the tumour suppressor retinoblastoma leads to a protumoral microenvironment via an increase in the secretion of the chemoattractant CCL2.
Thu Aug 01 00:00:00 EDT 2019
Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.
Cell reports
Tuit S,Salvagno C,Kapellos TS,Hau CS,Seep L,Oestreich M,Klee K,de Visser KE,Ulas T,Schultze JL
12-4801 was used in Flow cytometry/Cell sorting to show that a transgenic mouse tumor model can yield a TAM signature relevant for human breast cancer outcome prognosis and provide a generalizable strategy for determining and applying immune cell signatures provided the murine model reflects the human disease.
Tue Oct 29 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
12-4801 was used in Flow cytometry/Cell sorting to provide genetic evidence supporting that NKG2A and the inhibitory members of Ly49 family receptors synergize to regulate NK cell education.
Fri Nov 01 00:00:00 EDT 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
12-4801-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers.
Nature communications
Zhang F,Parayath NN,Ene CI,Stephan SB,Koehne AL,Coon ME,Holland EC,Stephan MT
12-4801 was used in Flow cytometry/Cell sorting to reprogramme tumor-associated macrophages into tumoricidal cells using mRNA nanoparticles. Local delivery of nanoparticles is a promising theraputic target.
Tue Sep 03 00:00:00 EDT 2019
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
Immunity
Wang M,Zhang S,Zheng G,Huang J,Songyang Z,Zhao X,Lin X
12-4801 was used in Flow cytometry/Cell sorting to show CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis.
Tue Jul 17 00:00:00 EDT 2018
Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection.
Cell metabolism
Tucey TM,Verma J,Harrison PF,Snelgrove SL,Lo TL,Scherer AK,Barugahare AA,Powell DR,Wheeler RT,Hickey MJ,Beilharz TH,Naderer T,Traven A
12-4801 was used in Flow cytometry/Cell sorting to support the importance of maintaining glucose homeostasis for immune cell survival during Candida challenge and for host survival in systemic infection.
Tue May 01 00:00:00 EDT 2018
The β2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.
Cell host & microbe
Gluschko A,Herb M,Wiegmann K,Krut O,Neiss WF,Utermöhlen O,Krönke M,Schramm M
12-4801-82 was used in Flow Cytometry to investigate macrophage response to Listeria monocytogenes infection.
Wed Mar 14 00:00:00 EDT 2018
Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation.
Cellular & molecular immunology
Bussières-Marmen S,Vinette V,Gungabeesoon J,Aubry I,Pérez-Quintero LA,Tremblay ML
12-4801 was used in Flow cytometry/Cell sorting to support the protective function of TC-PTP against inflammatory bowel diseases, independently of its previously demonstrated role in intestinal immunity.
Sun Apr 01 00:00:00 EDT 2018
Insulin resistance causes inflammation in adipose tissue.
The Journal of clinical investigation
Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN
12-4801 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.
Mon Apr 02 00:00:00 EDT 2018
Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Journal of the American Society of Nephrology : JASN
Micanovic R,Khan S,Janosevic D,Lee ME,Hato T,Srour EF,Winfree S,Ghosh J,Tong Y,Rice SE,Dagher PC,Wu XR,El-Achkar TM
12-4801-82 was used in Flow Cytometry to suggest that interstitial THP positively regulates mononuclear phagocyte number, plasticity, and phagocytic activity.
Thu Mar 01 00:00:00 EST 2018
Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
EMBO molecular medicine
Echevarría-Vargas IM,Reyes-Uribe PI,Guterres AN,Yin X,Kossenkov AV,Liu Q,Zhang G,Krepler C,Cheng C,Wei Z,Somasundaram R,Karakousis G,Xu W,Morrissette JJ,Lu Y,Mills GB,Sullivan RJ,Benchun M,Frederick DT,Boland G,Flaherty KT,Weeraratna AT,Herlyn M,Amaravadi R,Schuchter LM,Burd CE,Aplin AE,Xu X,Villanueva J
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that BET proteins are overexpressed in NRAS-mutant melanoma, and that high levels of BRD4 are associated with poor patient survival.
Tue May 01 00:00:00 EDT 2018
Elimination of tumor by CD47/PD-L1 dual-targeting fusion protein that engages innate and adaptive immune responses.
mAbs
Liu B,Guo H,Xu J,Qin T,Guo Q,Gu N,Zhang D,Qian W,Dai J,Hou S,Wang H,Guo Y
12-4801 was used in Flow cytometry/Cell sorting to demonstrate the capacity of an elicited endogenous immune response against tumours and elucidate essential characteristics of synergistic innate and adaptive immune response.
Fri Jan 18 00:00:00 EST 2019
Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function.
Endocrinology
van der Spek AH,Surovtseva OV,Jim KK,van Oudenaren A,Brouwer MC,Vandenbroucke-Grauls CMJE,Leenen PJM,van de Beek D,Hernandez A,Fliers E,Boelen A
12-4801 was used in Flow cytometry/Cell sorting to study the role of optimal intracellular concentrations of the active thyroid hormone triiodothyronine in proinflammatory macrophage function.
Tue May 01 00:00:00 EDT 2018
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
12-4801 was used in Flow cytometry/Cell sorting to show that the deubiquitinase POH1 negatively regulates the immune response triggered by inflammasome activation.
Fri Oct 12 00:00:00 EDT 2018
Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin.
JCI insight
Dokoshi T,Zhang LJ,Nakatsuji T,Adase CA,Sanford JA,Paladini RD,Tanaka H,Fujiya M,Gallo RL
12-4801 was used in Flow cytometry/Cell sorting to suggest hyaluronidase plays an important role in reactive adipogenesis and host defense after injury.
Fri Nov 02 00:00:00 EDT 2018
Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice.
The Journal of biological chemistry
Spurthi KM,Sarikhani M,Mishra S,Desingu PA,Yadav S,Rao S,Maity S,Tamta AK,Kumar S,Majumdar S,Jain A,Raghuraman A,Khan D,Singh I,Samuel RJ,Ramachandra SG,Nandi D,Sundaresan NR
12-4801-82 was used in Flow cytometry/Cell sorting to investigate the role of corticotropin-releasing hormone neurons in the central amygdala.
Fri Aug 24 00:00:00 EDT 2018
AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy.
Cell reports
Juban G,Saclier M,Yacoub-Youssef H,Kernou A,Arnold L,Boisson C,Ben Larbi S,Magnan M,Cuvellier S,Théret M,Petrof BJ,Desguerre I,Gondin J,Mounier R,Chazaud B
12-4801 was used in Flow cytometry/Cell sorting to conclude that an AMPK-LTBP4 axis in inflammatory macrophages controls the production of TGF-β1, which is further activated by and acts on fibroblastic cells, leading to fibrosis in DMD.
Tue Nov 20 00:00:00 EST 2018
Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.
Frontiers in immunology
Lin N,Shay JES,Xie H,Lee DSM,Skuli N,Tang Q,Zhou Z,Azzam A,Meng H,Wang H,FitzGerald GA,Simon MC
12-4801 was used in Flow cytometry/Cell sorting to examine the effects of myeloid hypoxia-inducible factor signalling on acute colitis resolution.
Thu Sep 26 00:00:00 EDT 2019
Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation.
Nature communications
Izumi T,Imai J,Yamamoto J,Kawana Y,Endo A,Sugawara H,Kohata M,Asai Y,Takahashi K,Kodama S,Kaneko K,Gao J,Uno K,Sawada S,Kalinichenko VV,Ishigaki Y,Yamada T,Katagiri H
12-4801 was used in Immunohistochemistry to demonstrate that a vagus-macrophage-hepatocyte link regulates acute liver regeneration following liver injury and that this system is critical for promoting survival.
Thu Dec 13 00:00:00 EST 2018
CD8+ T cells in beige adipogenesis and energy homeostasis.
JCI insight
Moysidou M,Karaliota S,Kodela E,Salagianni M,Koutmani Y,Katsouda A,Kodella K,Tsakanikas P,Ourailidou S,Andreakos E,Kostomitsopoulos N,Skokos D,Chatzigeorgiou A,Chung KJ,Bornstein S,Sleeman MW,Chavakis T,Karalis KP
12-4801 was used in Flow cytometry/Cell sorting to investigate whether lymphocytes participate in the regulation of energy homeostasis in the white adipose tissue.
Thu Mar 08 00:00:00 EST 2018
Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.
Oncotarget
Mertens B,Cristina de Araujo Nogueira T,Topalis D,Stranska R,Snoeck R,Andrei G
12-4801 was used in Flow cytometry/Cell sorting to identify the potential use of cidofovir in therapeutic strategies to kill tumour cells and influence the immune system to fight cancer.
Tue Apr 24 00:00:00 EDT 2018
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Nature communications
Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H
12-4801 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.
Mon Sep 24 00:00:00 EDT 2018
Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.
Journal of thrombosis and haemostasis : JTH
Lai JD,Cartier D,Hartholt RB,Swystun LL,van Velzen AS,den Haan JMM,Hough C,Voorberg J,Lillicrap D
12-4801 was used in Flow cytometry/Cell sorting to assess cellular interactions and expression profiles in hemophilia A mice.
Thu Mar 01 00:00:00 EST 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
12-4801 was used in Flow cytometry/Cell sorting to demonstrate for the first time that type 2 diabetes mellitus induces an haematopoietic stem cell-autonomous mechanism that causes impaired wound healing.
Tue Jan 02 00:00:00 EST 2018
Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging.
EBioMedicine
Lin JB,Sene A,Santeford A,Fujiwara H,Sidhu R,Ligon MM,Shankar VA,Ban N,Mysorekar IU,Ory DS,Apte RS
12-4801 was used in Flow cytometry/Cell sorting to characterise the oxysterol signatures which distinguish age-related macular degeneration from physiologic ageing.
Fri Jun 01 00:00:00 EDT 2018
Hif1α Deletion Limits Tissue Regeneration via Aberrant B Cell Accumulation in Experimental Pancreatitis.
Cell reports
Lee KE,Spata M,Maduka R,Vonderheide RH,Simon MC
12-4801 was used in Flow cytometry/Cell sorting to study the crosstalk between pancreatic hypoxia-inducible factor 1α expression and the B cell trafficking that regulates tissue regeneration.
Tue Jun 19 00:00:00 EDT 2018
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
Nature
Camell CD,Sander J,Spadaro O,Lee A,Nguyen KY,Wing A,Goldberg EL,Youm YH,Brown CW,Elsworth J,Rodeheffer MS,Schultze JL,Dixit VD
12-4801 was used in Flow cytometry/Cell sorting to show that adipose tissue macrophages regulate the age-related reduction in adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.
Thu Oct 05 00:00:00 EDT 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
12-4801 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.
Circulation research
Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R
12-4801 was used in Flow cytometry/Cell sorting to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.
Fri Mar 31 00:00:00 EDT 2017
Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.
Critical care (London, England)
Gutbier B,Jiang X,Dietert K,Ehrler C,Lienau J,Van Slyke P,Kim H,Hoang VC,Maynes JT,Dumont DJ,Gruber AD,Weissmann N,Mitchell TJ,Suttorp N,Witzenrath M
12-4801 was used in Flow cytometry/Cell sorting to show polyethylene glycol-clustered Tie2-binding peptide vasculotide can reduce pulmonary hyperpermeability.
Mon Nov 13 00:00:00 EST 2017
The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation.
Kidney international
Lv LL,Tang PM,Li CJ,You YK,Li J,Huang XR,Ni J,Feng M,Liu BC,Lan HY
12-4801-82 was used in Immunocytochemistry-immunoflourescence to investigate the role of Mincle (macrophage-inducible C-type lectin, Clec4e) in kidney disease.
Wed Mar 01 00:00:00 EST 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
12-4801 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
12-4801 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
12-4801 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.
Frontiers in immunology
Blank T,Goldmann T,Koch M,Amann L,Schön C,Bonin M,Pang S,Prinz M,Burnet M,Wagner JE,Biel M,Michalakis S
12-4801 was used in Flow cytometry/Cell sorting to study microglia activation in the development of retinitis pigmentosa.
Wed Nov 20 00:00:00 EST 2019
1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2-Hemeoxygenase-1-HMGB1 Pathway in Macrophages.
Frontiers in immunology
Rao Z,Zhang N,Xu N,Pan Y,Xiao M,Wu J,Zhou H,Yang S,Chen Y
12-4801 was used in Western Blotting to report that 1,25(OH)2D3 treatment improves the survival rate in LPS-induced mouse sepsis model by blocking high-mobility group box 1 secretion.
Wed Nov 20 00:00:00 EST 2019
Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4+ Th2 responses and promote chronic infection.
Mucosal immunology
Valanparambil RM,Tam M,Jardim A,Geary TG,Stevenson MM
12-4801 was used in Flow cytometry/Cell sorting to study the exact identity and role of the F4/80-CD11b+Gr+ cells accumulating around encysting larvae in intestinal tissue during primary Heligmosomoides polygyrus bakeri infection in mice.
Sun Jan 01 00:00:00 EST 2017
Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition.
Genes & nutrition
Roselli M,Devirgiliis C,Zinno P,Guantario B,Finamore A,Rami R,Perozzi G
12-4801 was used in Flow cytometry/Cell sorting to study, using a mouse model, the effects of supplementary dietary microbes on obesity-associated inflammation and gut microbiota composition.
Thu Oct 01 00:00:00 EDT 2020
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.
Nature communications
Xu WW,Li B,Guan XY,Chung SK,Wang Y,Yip YL,Law SY,Chan KT,Lee NP,Chan KW,Xu LY,Li EM,Tsao SW,He QY,Cheung AL
12-4801 was used in Flow cytometry/Cell sorting to investigate how the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Fri Feb 10 00:00:00 EST 2017
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.
Nature communications
Xu WW,Li B,Guan XY,Chung SK,Wang Y,Yip YL,Law SY,Chan KT,Lee NP,Chan KW,Xu LY,Li EM,Tsao SW,He QY,Cheung AL
12-4801 was used in Flow cytometry/Cell sorting to investigate how the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Fri Feb 10 00:00:00 EST 2017
PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.
Scientific reports
Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X
12480182 was used in immunohistochemistry - frozen section to assess the role of pigment epithelium-derived factor in macrophage recruitment and polarization
Fri Feb 17 00:00:00 EST 2017
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages.
Oncoimmunology
Kersten K,Coffelt SB,Hoogstraat M,Verstegen NJM,Vrijland K,Ciampricotti M,Doornebal CW,Hau CS,Wellenstein MD,Salvagno C,Doshi P,Lips EH,Wessels LFA,de Visser KE
12-4801 was used in Flow cytometry/Cell sorting to demonstrate mammary tumor-derived CCL2 can facilitate the breast cancer-induced pro-metastatic systemic inflammatory gamma delta T cell-IL17–neutrophil axis.
Sat Jan 29 00:00:00 EST 2022
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.
Nature communications
Ratsimandresy RA,Chu LH,Khare S,de Almeida L,Gangopadhyay A,Indramohan M,Misharin AV,Greaves DR,Perlman H,Dorfleutner A,Stehlik C
12-4801 was used in Flow cytometry/Cell sorting to investigate the complex interactions governing inflammasome assembly and function.
Mon Jun 05 00:00:00 EDT 2017
Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy.
JCI insight
Yanagita T,Murata Y,Tanaka D,Motegi SI,Arai E,Daniwijaya EW,Hazama D,Washio K,Saito Y,Kotani T,Ohnishi H,Oldenborg PA,Garcia NV,Miyasaka M,Ishikawa O,Kanai Y,Komori T,Matozaki T
12-4801 was used in Flow cytometry/Cell sorting to show that SIRPα is highly expressed in human renal cell carcinoma and melanoma, and that anti-SIRPα antibody blocks the interaction with CD47, suppressing tumor formation by renal cell carcinoma or melanoma cells.
Thu Jan 12 00:00:00 EST 2017
Gastric TFF1 Expression from Acute to Chronic Helicobacter Infection.
Frontiers in cellular and infection microbiology
Esposito R,Morello S,Vllahu M,Eletto D,Porta A,Tosco A
12-4801 was used in Immunohistochemistry-immunofluorescence to suggest that TFF1 might help cells to counteract bacteria colonization and the development of a chronic inflammation.
Mon Jul 09 00:00:00 EDT 2018
Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury.
Scientific reports
Rossi M,Thierry A,Delbauve S,Preyat N,Soares MP,Roumeguère T,Leo O,Flamand V,Le Moine A,Hougardy JM
12-4801 was used in Flow cytometry/Cell sorting to determine the role of heme oxygenase-1 during renal ischemia-reperfusion injury.
Wed Mar 15 00:00:00 EDT 2017
Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health.
Scientific reports
Novince CM,Whittow CR,Aartun JD,Hathaway JD,Poulides N,Chavez MB,Steinkamp HM,Kirkwood KA,Huang E,Westwater C,Kirkwood KL
12-4801 was used in Flow cytometry/Cell sorting to study the infulence of commensal gut microbiota in the skeletal homeosasis of adult mice.
Tue Jul 18 00:00:00 EDT 2017
Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling.
Oncotarget
Li CG,Yan L,Jing YY,Xu LH,Liang YD,Wei HX,Hu B,Pan H,Zha QB,Ouyang DY,He XH
12-4801 was used in Flow cytometry/Cell sorting to investigate how berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling.
Tue Jan 03 00:00:00 EST 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
12-4801 was used in Flow cytometry/Cell sorting to demonstrate in colon and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-L1 expression on both cancer and immune cells in the tumour.
Mon Mar 27 00:00:00 EDT 2017
Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome.
Nature communications
Douam F,Hrebikova G,Albrecht YE,Sellau J,Sharon Y,Ding Q,Ploss A
12-4801 was used in Flow cytometry/Cell sorting to demonstrate the tracking of and sense viral RNA at single-cell resolution within complex subsets of the human and murine immune system in different mouse models.
Tue Mar 14 00:00:00 EDT 2017
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.
Nature communications
Veglia F,Tyurin VA,Mohammadyani D,Blasi M,Duperret EK,Donthireddy L,Hashimoto A,Kapralov A,Amoscato A,Angelini R,Patel S,Alicea-Torres K,Weiner D,Murphy ME,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
12-4801-82 was used in Functional assays to demonstrate a mechanism regulating cross-presentation in cancer and suggest potential therapeutic avenues.
Thu Dec 14 00:00:00 EST 2017
Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.
Cell death discovery
Kip E,Nazé F,Suin V,Vanden Berghe T,Francart A,Lamoral S,Vandenabeele P,Beyaert R,Van Gucht S,Kalai M
12-4801 was used in Flow cytometry/Cell sorting to examine the role of specific caspases in cell death and disease development upon infection with rabies virus.
Tue Sep 29 00:00:00 EDT 2020
Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.
PloS one
Kawakubo M,Demehri S,Manstein D
12-4801 was used in Flow cytometry/Cell sorting to explore the utility of ablative fractional photothermolysis in treating oncological indications, including induction of local tumour regression and inducing anti-tumour immunity.
Fri Oct 13 00:00:00 EDT 2017
Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.
PloS one
Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ
12-4801 was used in Flow cytometry/Cell sorting to study the effect of biphosphonates suppressed proteosteoclasts releasing PDGF-BB, and their role in coupling angiogenesis and osteogenesis in BRONJ manifestation.
Mon Sep 18 00:00:00 EDT 2017
Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo.
mBio
Douam F,Soto Albrecht YE,Hrebikova G,Sadimin E,Davidson C,Kotenko SV,Ploss A
12-4801 was used in Flow cytometry/Cell sorting to analyse the role of type III interferon (IFN)-mediated signaling in controlling the infection and attenuation of the live attenuated yellow virus strain, YFV-17D.
Tue Aug 15 00:00:00 EDT 2017
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.
Nature immunology
Garaude J,Acín-Pérez R,Martínez-Cano S,Enamorado M,Ugolini M,Nistal-Villán E,Hervás-Stubbs S,Pelegrín P,Sander LE,Enríquez JA,Sancho D
12-4801 was used in Flow cytometry/Cell sorting to identify macrophage ETC complex I adaptations as an early immunological-metabolic transition checkpoint against bacterial infection.
Thu Sep 01 00:00:00 EDT 2016
FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.
The Journal of clinical investigation
Haemmerle M,Bottsford-Miller J,Pradeep S,Taylor ML,Choi HJ,Hansen JM,Dalton HJ,Stone RL,Cho MS,Nick AM,Nagaraja AS,Gutschner T,Gharpure KM,Mangala LS,Rupaimoole R,Han HD,Zand B,Armaiz-Pena GN,Wu SY,Pecot CV,Burns AR,Lopez-Berestein G,Afshar-Kharghan V,Sood AK
12-4801 was used in Flow cytometry/Cell sorting to identify focal adhesion kinase, FAK, as a target for ovarian cancer management in situations in which antiangiogenic agents are withdrawn.
Mon May 02 00:00:00 EDT 2016
Immune activation caused by vascular oxidation promotes fibrosis and hypertension.
The Journal of clinical investigation
Wu J,Saleh MA,Kirabo A,Itani HA,Montaniel KR,Xiao L,Chen W,Mernaugh RL,Cai H,Bernstein KE,Goronzy JJ,Weyand CM,Curci JA,Barbaro NR,Moreno H,Davies SS,Roberts LJ,Madhur MS,Harrison DG
12-4801 was used in Flow cytometry/Cell sorting to explore the physiological consequences of excessive production of reactive oxygen species in vascular tissues.
Fri Jan 01 00:00:00 EST 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
12-4801 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Alternatively activated macrophages determine repair of the infarcted adult murine heart.
The Journal of clinical investigation
Shiraishi M,Shintani Y,Shintani Y,Ishida H,Saba R,Yamaguchi A,Adachi H,Yashiro K,Suzuki K
12-4801 was used in Immunocytochemistry to study repair of the infarcted adult murine heart determined by alternatively activated macrophages.
Wed Jun 01 00:00:00 EDT 2016
The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation.
Nucleic acids research
Tiedje C,Diaz-Muñoz MD,Trulley P,Ahlfors H,Laaß K,Blackshear PJ,Turner M,Gaestel M
12-4801 was used in Flow cytometry/Cell sorting to uncover a role of TTP as a suppressor of feedback inhibitors of inflammation and highlight the importance of TTP activity-regulation by MK2 to control the pro-inflammatory response.
Tue Sep 06 00:00:00 EDT 2016
G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers.
Protein & cell
Li W,Zhang X,Chen Y,Xie Y,Liu J,Feng Q,Wang Y,Yuan W,Ma J
12-4801 was used in Flow cytometry/Cell sorting to indicate that G-CSF is a critical regulating molecule in the migration, proliferation and functional maintenance of myeloid derived suppressor cells.
Mon Feb 01 00:00:00 EST 2016
Leishmania infantum and Leishmania braziliensis: Differences and Similarities to Evade the Innate Immune System.
Frontiers in immunology
Falcão Sde A,Jaramillo TM,Ferreira LG,Bernardes DM,Santana JM,Favali CB
12-4801 was used in Flow cytometry/Cell sorting to investigate the similarities and differences between the ways in which leishmania infantum and leishmania braziliensis evade the innate immune system..
Thu Aug 18 00:00:00 EDT 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
12-4801 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 EST 2016
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.
Molecular metabolism
Johnson AR,Qin Y,Cozzo AJ,Freemerman AJ,Huang MJ,Zhao L,Sampey BP,Milner JJ,Beck MA,Damania B,Rashid N,Galanko JA,Lee DP,Edin ML,Zeldin DC,Fueger PT,Dietz B,Stahl A,Wu Y,Mohlke KL,Makowski L
12-4801 was used in Flow cytometry/Cell sorting to outline a novel mechanism for regulating adipose tissue homoeostasis and inflammation through metabolic reprogramming of macrophages; directed by fatty acid transport protein 1.
Fri Jul 01 00:00:00 EDT 2016
Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype.
The Journal of cell biology
Capote J,Kramerova I,Martinez L,Vetrone S,Barton ER,Sweeney HL,Miceli MC,Spencer MJ
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that OPN ablation promotes muscle repair via macrophage secretion of pro-myogenic growth factors.
Mon Apr 25 00:00:00 EDT 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Sun May 01 00:00:00 EDT 2016
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Hilpert C,Sitte S,Matthies A,Voehringer D
12-4801 was used in Flow cytometry/Cell sorting to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.
Sat Oct 01 00:00:00 EDT 2016
An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment.
Journal of immunology (Baltimore, Md. : 1950)
Xu Y,Romero R,Miller D,Kadam L,Mial TN,Plazyo O,Garcia-Flores V,Hassan SS,Xu Z,Tarca AL,Drewlo S,Gomez-Lopez N
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that decidual M1-like macrophages are associated with spontaneous preterm labor.
Tue Mar 15 00:00:00 EDT 2016
Effect of Amblyomma maculatum (Acari: Ixodidae) Saliva on the Acute Cutaneous Immune Response to Rickettsia parkeri Infection in a Murine Model.
Journal of medical entomology
Banajee KH,Verhoeve VI,Harris EK,Macaluso KR
12-4801 was used in Flow cytometry/Cell sorting to investigate whether Amblyomma maculatum saliva enhances Rickettsia parkeri infection via downregulation of the acute cellular and cytokine immune response.
Tue Nov 01 00:00:00 EDT 2016
PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.
Cell death & disease
Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J
12-4801 was used in Flow cytometry/Cell sorting to reveal that Per1 interaction with PPAR-γ prevents an excessive innate immune response in endotoxin-induced liver injury.
Thu Apr 07 00:00:00 EDT 2016
Progesterone Alleviates Endometriosis via Inhibition of Uterine Cell Proliferation, Inflammation and Angiogenesis in an Immunocompetent Mouse Model.
PloS one
Li Y,Adur MK,Kannan A,Davila J,Zhao Y,Nowak RA,Bagchi MK,Bagchi IC,Li Q
12-4801 was used in Immunohistochemistry to investigate the role of progesterone in development of endometriosis.
Tue Jun 06 00:00:00 EDT 2017
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
12-4801 was used in Flow cytometry/Cell sorting to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.
Nature communications
Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC
12-4801 was used in Flow cytometry/Cell sorting to show that TFF2 is released by vagally modulated memory T cells to suppress the expansion of myeloid-derived suppressor cells through CXCR4.
Thu Feb 04 00:00:00 EST 2016
Splenic Leukocytes Traffic to the Thyroid and Produce a Novel TSHβ Isoform during Acute Listeria monocytogenes Infection in Mice.
PloS one
Montufar-Solis D,Klein JR
12-4801 was used in Flow cytometry/Cell sorting to show that within three days of systemic infection of mice with Listeria monocytogenes, splenic leukocytes synthesized elevated levels of TSHβv.
Mon Jul 11 00:00:00 EDT 2016
Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.
Respiratory research
Baker K,Raemdonck K,Dekkak B,Snelgrove RJ,Ford J,Shala F,Belvisi MG,Birrell MA
12-4801 was used in Flow cytometry/Cell sorting to study the role of TRPV1 in rodent models of asthma, showing that TRPV1 KO or pharmacological inhibition of TRPV1 leads to decreased symptoms, suggesting it may be a target for further investigation.
Thu Jun 02 00:00:00 EDT 2016
Fish Oil-Based Fat Emulsion Reduces Acute Kidney Injury and Inflammatory Response in Antibiotic-Treated Polymicrobial Septic Mice.
Nutrients
Shih JM,Shih YM,Pai MH,Hou YC,Yeh CL,Yeh SL
12-4801 was used in Flow cytometry/Cell sorting to suggest that administration of a fish oil-based emulsion attenuates inflammation and offers renal protection under conditions of antibiotic-treated polymicrobial sepsis.
Tue Mar 15 00:00:00 EDT 2016
Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance.
Scientific reports
Winkler JW,Orr SK,Dalli J,Cheng CY,Sanger JM,Chiang N,Petasis NA,Serhan CN
12-4801 was used in Flow cytometry/Cell sorting to identify endogenous resolvin D4 in human tissues that persists late into the resolution phase of acute murine Staphylococcus aureus infections.
Fri Jan 08 00:00:00 EST 2016
Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.
Oncogene
Deguchi A,Tomita T,Ohto U,Takemura K,Kitao A,Akashi-Takamura S,Miyake K,Maru Y
12-4801-82 was used in Flow cytometry/Cell sorting to find that both tumor volume and pulmonary recruitment of myeloid-derived suppressor cells were reduced with the treatment of Eritoran for five consecutive days.
Thu Mar 17 00:00:00 EDT 2016
Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.
Oncoimmunology
Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW
12-4801 was used in Flow cytometry/Cell sorting to advocate the use of protein oxidation-inducing modalities like irradiation for increasing the immunogenicity of tumour lysate/cells used for pulsing DC vaccines.
Mon Feb 01 00:00:00 EST 2016
Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice.
Oncotarget
Pyo KH,Lee YW,Lim SM,Shin EH
12-4801 was used in Flow cytometry/Cell sorting to explore the potential of TgPLP as an adjuvant in autologous whole-tumour-cell vaccines.
Tue Nov 08 00:00:00 EST 2016
Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.
Nature medicine
Dalli J,Chiang N,Serhan CN
12-4801 was used in Flow cytometry/Cell sorting to elucidate the structures of four new host-protective molecules produced in neutrophil-endothelial cocultures that increase with atorvastatin and clear infections.
Tue Sep 01 00:00:00 EDT 2015
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine
Wilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP
12-4801 was used in Flow cytometry/Cell sorting to show AIM2 regulates colon tumorigenesis by reducing activation of both DNA-PK and Akt, suggesting that Akt inhibitors could be used in treatment of certain cancers.
Sat Aug 01 00:00:00 EDT 2015
Therapy-induced tumour secretomes promote resistance and tumour progression.
Nature
Obenauf AC,Zou Y,Ji AL,Vanharanta S,Shu W,Shi H,Kong X,Bosenberg MC,Wiesner T,Rosen N,Lo RS,Massagué J
12-4801 was used in Flow cytometry/Cell sorting to investigate drug resistance to kinase inhibitors in cancer, showing that therapy-induced tumour secretomes promote outgrowth, dissemination and metastasis, and hence tumour progression.
Thu Apr 16 00:00:00 EDT 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
12-4801 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
12-4801 was used in Flow cytometry/Cell sorting to investigate the critical niche components and resident signals required for hematopoietic stem cell induction and self-renewal ex vivo.
Fri May 01 00:00:00 EDT 2015
Macrophage and epithelial cell H-ferritin expression regulates renal inflammation.
Kidney international
Bolisetty S,Zarjou A,Hull TD,Traylor AM,Perianayagam A,Joseph R,Kamal AI,Arosio P,Soares MP,Jeney V,Balla J,George JF,Agarwal A
12-4801 was used in Flow cytometry/Cell sorting to explore the critical role of the heavy subunit of ferritin in tubular-macrophage cross-talk during kidney injury.
Wed Jul 01 00:00:00 EDT 2015
T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.
Journal of the American Society of Nephrology : JASN
Noel S,Martina MN,Bandapalle S,Racusen LC,Potteti HR,Hamad AR,Reddy SP,Rabb H
12-4801 was used in Flow cytometry/Cell sorting to study how T lymphocyte-specific activation of Nrf2 protects from IR-induced AKI, and investigate the novel mechanism of tissue protection behind this.
Tue Dec 01 00:00:00 EST 2015
Limited Efficacy of Antibacterial Vaccination Against Secondary Serotype 3 Pneumococcal Pneumonia Following Influenza Infection.
The Journal of infectious diseases
Metzger DW,Furuya Y,Salmon SL,Roberts S,Sun K
12-4801 was used in Flow cytometry/Cell sorting to show that antibacterial vaccination is only partially effective in protection against secondary serotype 3 pneumococcal pneumonia following influenza.
Sat Aug 01 00:00:00 EDT 2015
The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis.
Journal of virology
Fehr AR,Athmer J,Channappanavar R,Phillips JM,Meyerholz DK,Perlman S
12-4801 was used in Flow cytometry/Cell sorting to study the importance of a specific enzyme on the replication and virulence of a viral pathogen.
Sun Feb 01 00:00:00 EST 2015
Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Csóka B,Németh ZH,Törő G,Idzko M,Zech A,Koscsó B,Spolarics Z,Antonioli L,Cseri K,Erdélyi K,Pacher P,Haskó G
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that targeting P2X7 receptors provides a new opportunity for harnessing an endogenous protective immune mechanism in the treatment of sepsis.
Tue Sep 01 00:00:00 EDT 2015
Bone marrow angiotensin AT2 receptor deficiency aggravates atherosclerosis development by eliminating macrophage liver X receptor-mediated anti-atherogenic actions.
Journal of the renin-angiotensin-aldosterone system : JRAAS
Kato T,Kawahito H,Kishida S,Irie D,Wakana N,Kikai M,Takata H,Ogata T,Ueyama T,Matoba S,Yamada H
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that bone marrow angiotensin II type 2 deficiency aggravates atherosclerosis by eliminating the anti-atherogenic properties of macrophages elicited by liver X receptor Β activation.
Tue Dec 01 00:00:00 EST 2015
Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages.
Infection and immunity
Carrasco SE,Troxell B,Yang Y,Brandt SL,Li H,Sandusky GE,Condon KW,Serezani CH,Yang XF
12-4801 was used in Flow cytometry/Cell sorting to provide evidence that mononuclear phagocytes play a key role in clearance of the ospC mutant and that OspC promotes spirochetes'' evasion of macrophages during early Lyme borreliosis.
Tue Dec 01 00:00:00 EST 2015
The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.
Infection and immunity
Shourian M,Flaczyk A,Angers I,Mindt BC,Fritz JH,Qureshi ST
12-4801 was used in Flow cytometry/Cell sorting to show that Cryptococcus neoformans infected lungs showed a significantly higher number of neutrophils, exudate macrophages, CD11b(+) dendritic cells, and CD4(+) cells in B6.CBA-Cnes2 than in C57BL/6 mice.
Tue Dec 01 00:00:00 EST 2015
Functions of miR-146a and miR-222 in Tumor-associated Macrophages in Breast Cancer.
Scientific reports
Li Y,Zhao L,Shi B,Ma S,Xu Z,Ge Y,Liu Y,Zheng D,Shi J
12-4801 was used in Flow cytometry/Cell sorting to study the role of endogenous miRNAs in controlling the polarisation and function of tumour-associated macrophages in breast cancer.
Tue Dec 22 00:00:00 EST 2015
Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages.
PloS one
Incio J,Suboj P,Chin SM,Vardam-Kaur T,Liu H,Hato T,Babykutty S,Chen I,Deshpande V,Jain RK,Fukumura D
12-4801 was used in Flow cytometry/Cell sorting to examine the effect of metformin on pancreatic stellate cell activity, fibrosis and inflammation in pancreatic ductal adenocarcinomas.
Tue Jun 21 00:00:00 EDT 2016
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Nature communications
Ito M,Shichita T,Okada M,Komine R,Noguchi Y,Yoshimura A,Morita R
12-4801 was used in Flow cytometry/Cell sorting to report that Bruton's tyrosine kinase (BTK) is an essential component of the NLRP3 inflammasome, in which BTK physically interacts with ASC and NLRP3.
Wed Jun 10 00:00:00 EDT 2015
4T1 Murine Mammary Carcinoma Cells Enhance Macrophage-Mediated Innate Inflammatory Responses.
PloS one
Madera L,Greenshields A,Coombs MR,Hoskin DW
12-4801 was used in Flow cytometry/Cell sorting to investigate how cancers affect macrophage-dependent innate host defence, showing that they enhance macrophage-mediated innate inflammatory responses.
Tue May 03 00:00:00 EDT 2016
Differential Contribution of Acute and Chronic Inflammation to the Development of Murine Mammary 4T1 Tumors.
PloS one
Rodrigues Viana CT,Castro PR,Marques SM,Paz Lopes MT,Gonçalves R,Campos PP,Andrade SP
12-4801 was used in Flow cytometry/Cell sorting to investigate the influence of acute and chronic inflammation on the development of a murine mammary tumour.
Mon Apr 18 00:00:00 EDT 2016
Hierarchal Autophagic Divergence of Hematopoietic System.
The Journal of biological chemistry
Cao Y,Zhang S,Yuan N,Wang J,Li X,Xu F,Lin W,Song L,Fang Y,Wang Z,Wang Z,Zhang H,Zhang Y,Zhao W,Hu S,Zhang X,Wang J
12-4801 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells rely on ATG7-dependent canonical autophagy, while terminally differentiated cells can utilise alternative mechanisms of autophagy.
Fri Sep 18 00:00:00 EDT 2015
Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors.
Cell & bioscience
Wang Y,Jiang M,Li Z,Wang J,Du C,Yanyang L,Yu Y,Wang X,Zhang N,Zhao M,Wang L,Li M,Luo F
12-4801 was used in Flow cytometry/Cell sorting to investigate anti-tumour treatment using endostatin and mechanisms of resistance to the treatment.
Fri Dec 25 00:00:00 EST 2015
Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.
Immunity, inflammation and disease
Roberts LM,Ledvina HE,Tuladhar S,Rana D,Steele SP,Sempowski GD,Frelinger JA
12-4801 was used in Flow cytometry/Cell sorting to reveal the myriad of molecular side effects observable after diphtheria toxin-mediated depletion of alveolar macrophages.
Mon Jun 01 00:00:00 EDT 2015
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
12-4801 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 EDT 2016
Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature.
Nature communications
Kolaczkowska E,Jenne CN,Surewaard BG,Thanabalasuriar A,Lee WY,Sanz MJ,Mowen K,Opdenakker G,Kubes P
12-4801 was used in Immunohistochemistry to demonstrate that NETs adhere to the blood vessel wall, persist for at least one day, and retain proteolytic activity.
Thu Mar 26 00:00:00 EDT 2015
A strategy to discover decoy chemokine ligands with an anti-inflammatory activity.
Scientific reports
Abboud D,Daubeuf F,Do QT,Utard V,Villa P,Haiech J,Bonnet D,Hibert M,Bernard P,Galzi JL,Frossard N
12-4801 was used in Flow cytometry/Cell sorting to describe the identification of two chemokines involved in the Th2-type of lung inflammation.
Wed Oct 07 00:00:00 EDT 2015
Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.
The Journal of biological chemistry
Hu N,Qiu Y,Dong F
12-4801 was used in Flow cytometry/Cell sorting to reveal an important mechanism by which G-CSF and M-CSF instruct neutrophil versus monocyte lineage choice.
Fri Oct 02 00:00:00 EDT 2015
Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response.
Stem cell research & therapy
Tan JL,Chan ST,Lo CY,Deane JA,McDonald CA,Bernard CC,Wallace EM,Lim R
12-4801 was used in Flow cytometry/Cell sorting to show that Tregs are required for hAEC-mediated macrophage polarisation and consequential mitigation of bleomycin-induced lung injury.
Thu Jan 29 00:00:00 EST 2015
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface.
Journal of visualized experiments : JoVE
Arenas-Hernandez M,Sanchez-Rodriguez EN,Mial TN,Robertson SA,Gomez-Lopez N
12-4801 was used in Flow cytometry/Cell sorting to isolate high numbers of viable leukocytes (>70%) with sufficiently conserved antigenic and functional properties from murine tissues at the maternal-fetal interface.
Thu May 21 00:00:00 EDT 2015
Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity.
Immunity
Jin J,Hu H,Li HS,Yu J,Xiao Y,Brittain GC,Zou Q,Cheng X,Mallette FA,Watowich SS,Sun SC
12-4801 was used in Flow cytometry/Cell sorting to report that the noncanonical NF-κB pathway is stimulated along with innate immune cell differentiation and viral infections, and has a vital role in negatively regulating type I interferon induction.
Thu Mar 20 00:00:00 EDT 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
12-4801 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
The Journal of experimental medicine
Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR
12-4801 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.
Mon Jul 28 00:00:00 EDT 2014
CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
The Journal of experimental medicine
Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P
12-4801 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.
Mon Dec 15 00:00:00 EST 2014
Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection.
Proceedings of the National Academy of Sciences of the United States of America
Dalli J,Chiang N,Serhan CN
12-4801 was used in Flow cytometry/Cell sorting to identify conserved chemical signals and pathways in mouse, and human tissues that enhance host immune responses to contain infections.
Tue Nov 04 00:00:00 EST 2014
Intravenous injection of MVA virus targets CD8+ lymphocytes to tumors to control tumor growth upon combinatorial treatment with a TLR9 agonist.
Cancer immunology research
Fend L,Gatard-Scheikl T,Kintz J,Gantzer M,Schaedler E,Rittner K,Cochin S,Fournel S,Préville X
12-4801 was used in Flow cytometry/Cell sorting to evaluate the impact of injection routes on therapeutic efficacy of a Modified Vaccinia virus Ankara viral vector expressing the human mucin 1 tumour-associated xeno-antigen.
Mon Dec 01 00:00:00 EST 2014
Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology
Bi X,Zhu X,Gao C,Shewale S,Cao Q,Liu M,Boudyguina E,Gebre AK,Wilson MD,Brown AL,Parks JS
12-4801 was used in Flow cytometry/Cell sorting to assess the atherosclerotic impact of myeloid cell ATP-binding cassette transporter A1.
Mon Sep 01 00:00:00 EDT 2014
A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis.
British journal of pharmacology
Gong W,Hu E,Dou H,Song Y,Yang L,Ji J,Li E,Tan R,Hou Y
12-4801 was used in Flow cytometry/Cell sorting to explore a 1,2-benzenediamine derivative FC-99 as a therapeutic candidate for sepsis.
Sat Nov 01 00:00:00 EDT 2014
Mannose-binding lectin is required for the effective clearance of apoptotic cells by adipose tissue macrophages during obesity.
Diabetes
Stienstra R,Dijk W,van Beek L,Jansen H,Heemskerk M,Houtkooper RH,Denis S,van Harmelen V,Willems van Dijk K,Tack CJ,Kersten S
12-4801 was used in Flow cytometry/Cell sorting to identify a novel role for mannose-binding lectin in the recognition and clearance of apoptotic adipocytes during obesity.
Mon Dec 01 00:00:00 EST 2014
Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy.
Journal of virology
Claudepierre MC,Hortelano J,Schaedler E,Kleinpeter P,Geist M,Remy-Ziller C,Brandely R,Tosch C,Laruelle L,Jawhari A,Menguy T,Marchand JB,Romby P,Schultz P,Hartmann G,Rooke R,Bonnefoy JY,Preville X,Rittner K
12-4801 was used in Flow cytometry/Cell sorting to show that the choice of an appropriate immune modulator can enhance vaccine function.
Thu May 01 00:00:00 EDT 2014
Altered macrophage phenotype transition impairs skeletal muscle regeneration.
The American journal of pathology
Wang H,Melton DW,Porter L,Sarwar ZU,McManus LM,Shireman PK
12-4801 was used in Flow cytometry/Cell sorting to study the effect of varying levels of inflammatory cell phenotypes in injured skeletal muscle on muscle regeneration at different times.
Tue Apr 01 00:00:00 EDT 2014
High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury.
Experimental neurology
Evans TA,Barkauskas DS,Myers JT,Hare EG,You JQ,Ransohoff RM,Huang AY,Silver J
12-4801 was used in Flow cytometry/Cell sorting to explore the in vivo cellular interactions involved in secondary axonal injury.
Tue Apr 01 00:00:00 EDT 2014
Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Little MC,Hurst RJ,Else KJ
12-4801 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.
Sat Nov 01 00:00:00 EDT 2014
Glutamine supplementation attenuates expressions of adhesion molecules and chemokine receptors on T cells in a murine model of acute colitis.
Mediators of inflammation
Hou YC,Wu JM,Wang MY,Wu MH,Chen KY,Yeh SL,Lin MT
12-4801 was used in Flow cytometry/Cell sorting to show that pretreatment with oral glutamine reduces adhesion molecule- and CCR9-expressing T cells, caused by dextran sulfate sodium exposure.
Sat Feb 07 00:00:00 EST 2015
Yersinia pseudotuberculosis efficiently escapes polymorphonuclear neutrophils during early infection.
Infection and immunity
Westermark L,Fahlgren A,Fällman M
12-4801 was used in Flow cytometry/Cell sorting to analyse bacterium-immune cell interactions in the intestinal lymphoid tissues of mice during early Yersinia pseudotuberculosis infection.
Sat Mar 01 00:00:00 EST 2014
Identification of early interactions between Francisella and the host.
Infection and immunity
Roberts LM,Tuladhar S,Steele SP,Riebe KJ,Chen CJ,Cumming RI,Seay S,Frothingham R,Sempowski GD,Kawula TH,Frelinger JA
12-4801 was used in Flow cytometry/Cell sorting to identify the first cells to respond to infections of various pathogens in the lungs of mice.
Sun Jun 01 00:00:00 EDT 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
12-4801-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route.
PloS one
Pisano F,Heine W,Rosenheinrich M,Schweer J,Nuss AM,Dersch P
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of PhoP in oral infections, showing that virulence of Yersinia pseudotuberculosis is influenced by PhoP and intra-species variations.
Thu Nov 12 00:00:00 EST 2015
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
PloS one
Deng B,Wang CW,Arnardottir HH,Li Y,Cheng CY,Dalli J,Serhan CN
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that human macrophages can produce a bioactive product with anti-inflammatory properties, identified in the maresin metabolome as maresin 2.
Mon Mar 30 00:00:00 EDT 2015
Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling.
Oncotarget
Zhang J,Cao J,Ma S,Dong R,Meng W,Ying M,Weng Q,Chen Z,Ma J,Fang Q,He Q,Yang B
12-4801 was used in Flow cytometry/Cell sorting to reveal a novel tumour hypoxia concept involving the macrophage phenotype shift, providing evidence for lung cancer intervention through modulating macrophage phenotype.
Thu Oct 30 00:00:00 EDT 2014
Tumor necrosis factor-α blocks differentiation and enhances suppressive activity of immature myeloid cells during chronic inflammation.
Immunity
Sade-Feldman M,Kanterman J,Ish-Shalom E,Elnekave M,Horwitz E,Baniyash M
12-4801 was used in Flow cytometry/Cell sorting to study how TNF has a fundamental role in promoting an immunosuppressive environment generated during chronic inflammation.
Thu Mar 21 00:00:00 EDT 2013
p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells.
The Journal of experimental medicine
Iannello A,Thompson TW,Ardolino M,Lowe SW,Raulet DH
12-4801 was used in Flow cytometry/Cell sorting to study how NK cells participate in the elimination of senescent tumours.
Mon Sep 23 00:00:00 EDT 2013
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes.
EMBO molecular medicine
Fevre C,Almeida AS,Taront S,Pedron T,Huerre M,Prevost MC,Kieusseian A,Cumano A,Brisse S,Sansonetti PJ,Tournebize R
12-4801 was used in Flow cytometry/Cell sorting to characterise a murine model recapitulating the formation of Mikulicz cells in lungs to assess the cellular origins of Mikulicz cells during K. rhinoscleromatis infection.
Mon Apr 01 00:00:00 EDT 2013
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
12-4801 was used in Flow cytometry/Cell sorting to analyse mesenchymal stem- and T-cell migration during experimental allergic encephalomyelitis.
Wed Mar 06 00:00:00 EST 2013
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Cancer immunology, immunotherapy : CII
Akhmetzyanova I,Zelinskyy G,Schimmer S,Brandau S,Altenhoff P,Sparwasser T,Dittmer U
12-4801 was used in Flow cytometry/Cell sorting to explore the role of effector CD4(+) T cells in the immune control of tumours.
Fri Feb 01 00:00:00 EST 2013
A chemokine-like viral protein enhances alpha interferon production by plasmacytoid dendritic cells but delays CD8+ T cell activation and impairs viral clearance.
Journal of virology
Wikstrom ME,Fleming P,Comerford I,McColl SR,Andoniou CE,Degli-Esposti MA
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that a chemokine-like protein from murine cytomegalovirus activates the early innate immune response and delays adaptive immunity, impairing viral clearance.
Mon Jul 01 00:00:00 EDT 2013
Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response.
International immunology
Müller U,Stenzel W,Piehler D,Grahnert A,Protschka M,Köhler G,Frey O,Held J,Richter T,Eschke M,Kamradt T,Brombacher F,Alber G
12-4801 was used in Flow cytometry/Cell sorting to indicate a key contribution of macrophage IL-4Rα expression to susceptibility in allergic bronchopulmonary mycosis.
Thu Aug 01 00:00:00 EDT 2013
GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.
Endocrinology
Panjwani N,Mulvihill EE,Longuet C,Yusta B,Campbell JE,Brown TJ,Streutker C,Holland D,Cao X,Baggio LL,Drucker DJ
12-4801 was used in Flow cytometry/Cell sorting to illustrate the actions of GLP-1R agonists on atherosclerosis, and indirect GLP-1R actions for the control of hepatic lipid accumulation.
Tue Jan 01 00:00:00 EST 2013
Mechanism and implications of CXCR4-mediated integrin activation by Porphyromonas gingivalis.
Molecular oral microbiology
Hajishengallis G,McIntosh ML,Nishiyama SI,Yoshimura F
12-4801 was used in Flow cytometry/Cell sorting to indicate that the interaction of Porphyromonas gingivalis with CXCR4 leads to inhibition of antimicrobial responses and enhancement of pro-adhesive responses.
Thu Aug 01 00:00:00 EDT 2013
Absence of platelet endothelial cell adhesion molecule 1, PECAM-1/CD31, in vivo increases resistance to Salmonella enterica serovar Typhimurium in mice.
Infection and immunity
Lovelace MD,Yap ML,Yip J,Muller W,Wijburg O,Jackson DE
12-4801 was used in Flow cytometry/Cell sorting to determine the functional role of PECAM-1 in susceptibility to murine primary in vivo infection with Salmonella enterica serovar Typhimurium and in in vitro inflammatory responses of peritoneal macrophages.
Sat Jun 01 00:00:00 EDT 2013
Properties of immature myeloid progenitors with nitric-oxide-dependent immunosuppressive activity isolated from bone marrow of tumor-free mice.
PloS one
Forghani P,Harris W,Giver CR,Mirshafiey A,Galipeau J,Waller EK
12-4801 was used in Flow cytometry/Cell sorting to determine the role of immature myeloid cells in regulating T-cell activation and proliferation in bone marrow.
Thu Jan 23 00:00:00 EST 2014
Macrophage migration inhibitory factor receptor CD74 mediates alphavirus-induced arthritis and myositis in murine models of alphavirus infection.
Arthritis and rheumatism
Herrero LJ,Sheng KC,Jian P,Taylor A,Her Z,Herring BL,Chow A,Leo YS,Hickey MJ,Morand EF,Ng LF,Bucala R,Mahalingam S
12-4801 was used in Flow cytometry/Cell sorting to investigate the role that CD74 plays in the immunopathogenesis of arthritic alphavirus infection and myositis in mice.
Tue Oct 01 00:00:00 EDT 2013
A missing PD-L1/PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner.
PloS one
Schuster C,Brosi H,Stifter K,Boehm BO,Schirmbeck R
12-4801 was used in Immunohistochemistry to study the induction of preproinsulin-specific CD8(+) T-cell responses and experimental autoimmune diabetes by DNA-based immunisation in several mouse models.
Tue Apr 08 00:00:00 EDT 2014
Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation.
PloS one
Ma S,Richardson JA,Bitmansour A,Solberg TD,Pidikiti R,Song K,Stojadinovic S,Vitetta ES,Meyer JJ
12-4801 was used in Flow cytometry/Cell sorting to investigate the effects of partial depletion of regulatory T cells alongside ionizing radiation on inflammation and tissue injury in mice.
Mon Jul 29 00:00:00 EDT 2013
Low frequency magnetic fields enhance antitumor immune response against mouse H22 hepatocellular carcinoma.
PloS one
Nie Y,Chen Y,Mou Y,Weng L,Xu Z,Du Y,Wang W,Hou Y,Wang T
12-4801 was used in Flow cytometry/Cell sorting to investigate the inhibitory effect of magnetic fields on tumour growth and its relatedness to the improvement of immune function.
Thu Sep 18 00:00:00 EDT 2014
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
Nature immunology
Xu H,Zhu J,Smith S,Foldi J,Zhao B,Chung AY,Outtz H,Kitajewski J,Shi C,Weber S,Saftig P,Li Y,Ozato K,Blobel CP,Ivashkiv LB,Hu X
12-4801 was used in Flow cytometry/Cell sorting to show that RBP-J augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classically activated M1 macrophages, and thus of innate immune responses to Listeria monocytogenes.
Sun May 20 00:00:00 EDT 2012
On the role of regulatory T cells during viral-induced inflammatory lesions.
Journal of immunology (Baltimore, Md. : 1950)
Veiga-Parga T,Suryawanshi A,Mulik S,Giménez F,Sharma S,Sparwasser T,Rouse BT
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3(+)CD4(+) Tregs during ongoing inflammatory reactions in ocular HSV-1 infection.
Sat Dec 15 00:00:00 EST 2012
Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hayashi C,Papadopoulos G,Gudino CV,Weinberg EO,Barth KR,Madrigal AG,Chen Y,Ning H,LaValley M,Gibson FC,Hamilton JA,Genco CA
12-4801 was used in Flow cytometry/Cell sorting to elucidate the cellular mechanisms that induce the development of atherosclerosis in response to chronic infection.
Mon Oct 01 00:00:00 EDT 2012
Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.
Journal of neuroinflammation
Horiuchi M,Wakayama K,Itoh A,Kawai K,Pleasure D,Ozato K,Itoh T
12-4801 was used in Flow cytometry/Cell sorting to compare microglial function in wild type and IRF8-deficient mice.
Fri Sep 28 00:00:00 EDT 2012
In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice.
Malaria research and treatment
Frita R,Carapau D,Mota MM,Hänscheid T
12-4801 was used in Flow cytometry/Cell sorting to report the long-term in vivo kinetics of Hemozoin in diverse organs in a murine model of malaria infection.
Thu Aug 23 00:00:00 EDT 2012
Characterization of omental immune aggregates during establishment of a latent gammaherpesvirus infection.
PloS one
Gray KS,Collins CM,Speck SH
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of the omentum in gammaherpesvirus pathogenesis during early MHV68 infection and long-term latency.
Tue Feb 19 00:00:00 EST 2013
Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein.
Nature
Park D,Han CZ,Elliott MR,Kinchen JM,Trampont PC,Das S,Collins S,Lysiak JJ,Hoehn KL,Ravichandran KS
12-4801 was used in Immunohistochemistry to show that mitochondrial membrane potential and Ucp2 are key molecular determinants of apoptotic cell clearance in mice.
Sun Aug 21 00:00:00 EDT 2011
RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Immunity
Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F
12-4801 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.
Fri Mar 25 00:00:00 EDT 2011
Indoleamine 2,3-dioxygenase and regulatory dendritic cells contribute to the allograft protection induced by infusion of donor-specific splenic stromal cells.
Cellular & molecular immunology
Liu L,Duan L,Gong M,Dai H,Gong Q,Zheng F,Tan Z,Wang C,Gong F,Fang M
12-4801 was used in Flow cytometry/Cell sorting to suggest that donor-derived splenic stromal cells could be used as a therapeutic target to promote transplantation tolerance.
Sat Jan 01 00:00:00 EST 2011
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
The Journal of clinical investigation
Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL
12-4801 was used in Flow cytometry/Cell sorting to investigate the relative contributions of different APC populations in IBD, showing that CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses.
Thu Dec 01 00:00:00 EST 2011
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.
The Journal of clinical investigation
Li J,Bessho K,Shivakumar P,Mourya R,Mohanty SK,Dos Santos JL,Miura IK,Porta G,Bezerra JA
12-4801 was used in Flow cytometry/Cell sorting to assess whether Th1-independent mechanisms can activate effector cells to induce biliary atresia.
Tue Nov 01 00:00:00 EDT 2011
Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.
PLoS biology
Toh B,Wang X,Keeble J,Sim WJ,Khoo K,Wong WC,Kato M,Prevost-Blondel A,Thiery JP,Abastado JP
12-4801 was used in Flow cytometry/Cell sorting to show that myeloid-derived suppressor cells preferentially infiltrate the primary tumour and actively promote cancer cell dissemination by inducing epithelial-mesenchymal transition.
Thu Sep 01 00:00:00 EDT 2011
Morphine, but not trauma, sensitizes to systemic Acinetobacter baumannii infection.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Breslow JM,Monroy MA,Daly JM,Meissler JJ,Gaughan J,Adler MW,Eisenstein TK
12-4801 was used in Flow cytometry/Cell sorting to support the hypothesis that morphine increases the likelihood of Acinetobacter infection in mice models.
Thu Dec 01 00:00:00 EST 2011
Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent.
Journal of virology
Heiber JF,Barber GN
12-4801 was used in Flow cytometry/Cell sorting to investigate the potential of p53-incorporating-VSV for the design of VSV therapies and as a basis for VSV-based vaccines.
Sat Oct 01 00:00:00 EDT 2011
Lineage-committed osteoclast precursors circulate in blood and settle down into bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Muto A,Mizoguchi T,Udagawa N,Ito S,Kawahara I,Abiko Y,Arai A,Harada S,Kobayashi Y,Nakamichi Y,Penninger JM,Noguchi T,Takahashi N
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that receptor activator of NF-κB-positive cells isolated from bone marrow and peripheral blood possess characteristics of quiescent osteoclast precursors in mice.
Thu Dec 01 00:00:00 EST 2011
Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss.
Sleep
Wisor JP,Clegern WC,Schmidt MA
12-4801 was used in Flow cytometry/Cell sorting to describe the baseline electroencephalographic sleep phenotype and the biochemical and electroencephalographic responses to sleep loss in TLR4-deficient mice.
Sat Oct 01 00:00:00 EDT 2011
Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice.
Immunology and cell biology
Liu G,Ma H,Qiu L,Li L,Cao Y,Ma J,Zhao Y
12-4801 was used in Flow cytometry/Cell sorting to provide evidence to support the unknown pathways for CD4(+)CD25(+) Treg cells to regulate innate immunity by promoting the differentiation of M2 macrophages as well as by inhibiting M1 macrophage induction by CD4(+)CD25(-) T cells in mice.
Sat Jan 01 00:00:00 EST 2011
Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Manthey HD,Thomas AC,Shiels IA,Zernecke A,Woodruff TM,Rolfe B,Taylor SM
12-4801 was used in Flow cytometry/Cell sorting to provide evidence for a proatherogenic role for C5a and identifies the CD88 antagonist PMX53 as a potential antiatherosclerotic drug.
Fri Jul 01 00:00:00 EDT 2011
Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.
Journal of immunology (Baltimore, Md. : 1950)
Bonnefoy F,Perruche S,Couturier M,Sedrati A,Sun Y,Tiberghien P,Gaugler B,Saas P
12-4801 was used in Flow cytometry/Cell sorting to indicate that PDCs are the major APC involved in Treg stimulation and generation in an immunosuppressive environment obtained through apoptotic cell infusion.
Sun May 15 00:00:00 EDT 2011
Plasmacytoid dendritic cells play a major role in apoptotic leukocyte-induced immune modulation.
Journal of immunology (Baltimore, Md. : 1950)
Bonnefoy F,Perruche S,Couturier M,Sedrati A,Sun Y,Tiberghien P,Gaugler B,Saas P
12-4801 was used in Flow cytometry/Cell sorting to indicate that PDCs are the major APC involved in Treg stimulation and generation in an immunosuppressive environment obtained through apoptotic cell infusion.
Sun May 15 00:00:00 EDT 2011
Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Legutko A,Marichal T,Fiévez L,Bedoret D,Mayer A,de Vries H,Klotz L,Drion PV,Heirman C,Cataldo D,Louis R,Thielemans K,Andris F,Leo O,Lekeux P,Desmet CJ,Bureau F
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of sirtuins in inflammation, showing that Sirtuin 1 promotes Th2 responses and airway allergy by repressing PPAR-γ activity.
Tue Nov 01 00:00:00 EDT 2011
Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice.
Journal of immunology (Baltimore, Md. : 1950)
Yu S,Cantorna MT
12-4801 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D deficiency on iNKT cells in mice.
Tue Feb 01 00:00:00 EST 2011
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component.
Journal of immunology (Baltimore, Md. : 1950)
Zhang W,Xu W,Xiong S
12-4801 was used in Flow cytometry/Cell sorting to discover a mechanism responsible for modulation of macrophage polarization in lupus nephritis, opening a potential therapeutic avenue for SLE.
Mon Aug 15 00:00:00 EDT 2011
Membrane-associated CD93 regulates leukocyte migration and C1q-hemolytic activity during murine peritonitis.
Journal of immunology (Baltimore, Md. : 1950)
Greenlee-Wacker MC,Briseño C,Galvan M,Moriel G,Velázquez P,Bohlson SS
12-4801 was used in Flow cytometry/Cell sorting to demonstrate and understand a heightened susceptibility to thioglycollate-induced peritonitis in CD93(-/-) mice.
Thu Sep 15 00:00:00 EDT 2011
Pseudomonas aeruginosa elastase provides an escape from phagocytosis by degrading the pulmonary surfactant protein-A.
PloS one
Kuang Z,Hao Y,Walling BE,Jeffries JL,Ohman DE,Lau GW
12-4801 was used in Flow cytometry/Cell sorting to study how P. aeruginosa secretions grant protection against SP-A-mediated opsonisation.
Fri Mar 16 00:00:00 EDT 2012
Study of camelpox virus pathogenesis in athymic nude mice.
PloS one
Duraffour S,Matthys P,van den Oord JJ,De Schutter T,Mitera T,Snoeck R,Andrei G
12-4801 was used in Flow cytometry/Cell sorting to confirm that NMRI immunocompetent mice are resistant to intranasal (i.n.) CMLV infection.
Thu Dec 01 00:00:00 EST 2011
Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol.
PloS one
Hegde VL,Nagarkatti PS,Nagarkatti M
12-4801 was used in Flow cytometry/Cell sorting to ameliorate experimental autoimmune hepatitis following activation of TRPV1 receptors in myeloid-derived suppressor cells by cannabidiol.
Fri Apr 01 00:00:00 EDT 2011
Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages.
Cell research
Wang Q,Ni H,Lan L,Wei X,Xiang R,Wang Y
12-4801 was used in Flow cytometry/Cell sorting to open new insights into how to reverse M2d macrophage-induced immune tolerance to improve the efficacy of immunotherapeutic approaches.
Tue Jun 01 00:00:00 EDT 2010
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Blood
Huber S,Hoffmann R,Muskens F,Voehringer D
12-4801 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.
Thu Oct 28 00:00:00 EDT 2010
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.)
Kohli R,Kirby M,Xanthakos SA,Softic S,Feldstein AE,Saxena V,Tang PH,Miles L,Miles MV,Balistreri WF,Woods SC,Seeley RJ
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that nongenetically modified mice maintained on an HFHC diet in addition to developing obesity have increased hepatic ROS and a NASH-like phenotype with significant fibrosis.
Wed Sep 01 00:00:00 EDT 2010
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America
Rodriguez-Manzanet R,Sanjuan MA,Wu HY,Quintana FJ,Xiao S,Anderson AC,Weiner HL,Green DR,Kuchroo VK
12-4801 was used in Flow cytometry/Cell sorting to investigate the significance of interactions between TIM-4 and phophatidylserine, showing that TIM-4 deficiency leads to T and B cell hyperactivity and autoimmunity.
Tue May 11 00:00:00 EDT 2010
T cell immunoglobulin- and mucin-domain-containing molecule-4 attenuates concanavalin A-induced hepatitis by regulating macrophage.
Journal of leukocyte biology
Xu L,Qi J,Zhao P,Liang X,Ju Y,Liu P,Liu B,Guo C,Zhang L,Ma C,Gao L
12-4801 was used in Flow cytometry/Cell sorting to study how Tim-4 plays an important role in alleviating liver damage through inhibition of macrophage activity.
Sun Aug 01 00:00:00 EDT 2010
MCP1 directs trafficking of hematopoietic stem cell-derived fibroblast precursors in solid tumor.
The American journal of pathology
Abangan RS,Williams CR,Mehrotra M,Duncan JD,Larue AC
12-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms regulating recruitment and homing of HSC-derived carcinoma-associated fibroblasts to the tumour microenvironment, showing that MCP1 directs trafficking.
Thu Apr 01 00:00:00 EDT 2010
A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Journal of immunology (Baltimore, Md. : 1950)
Anthony DA,Andrews DM,Chow M,Watt SV,House C,Akira S,Bird PI,Trapani JA,Smyth MJ
12-4801 was used in Flow cytometry/Cell sorting to demonstrate that granzymes should be considered as potential key regulators of inflammation.
Sun Aug 01 00:00:00 EDT 2010
17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Calippe B,Douin-Echinard V,Delpy L,Laffargue M,Lélu K,Krust A,Pipy B,Bayard F,Arnal JF,Guéry JC,Gourdy P
12-4801 was used in Flow cytometry/Cell sorting to investigate the effect of 17β-estradiol on macrophage effector functions under inflammatory conditions in vivo.
Thu Jul 15 00:00:00 EDT 2010
Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Hinson ER,Joshi NS,Chen JH,Rahner C,Jung YW,Wang X,Kaech SM,Cresswell P
12-4801 was used in Flow cytometry/Cell sorting to analyse viperin expression in vivo during two conditions which induce high and low levels of type 1 IFNs respectively.
Sat May 15 00:00:00 EDT 2010
Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis.
Infection and immunity
Correia A,Lermann U,Teixeira L,Cerca F,Botelho S,da Costa RM,Sampaio P,Gärtner F,Morschhäuser J,Vilanova M,Pais C
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence in a murine model of hematogenously disseminated candidiasis.
Mon Nov 01 00:00:00 EDT 2010
Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.
Infection and immunity
Shen Y,Kawamura I,Nomura T,Tsuchiya K,Hara H,Dewamitta SR,Sakai S,Qu H,Daim S,Yamamoto T,Mitsuyama M
12-4801 was used in Flow cytometry/Cell sorting to investigate receptor activation facilitating the phagocytosis of Listeria monocytogenes.
Tue Jun 01 00:00:00 EDT 2010
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
The Journal of clinical investigation
Bedoret D,Wallemacq H,Marichal T,Desmet C,Quesada Calvo F,Henry E,Closset R,Dewals B,Thielen C,Gustin P,de Leval L,Van Rooijen N,Le Moine A,Vanderplasschen A,Cataldo D,Drion PV,Moser M,Lekeux P,Bureau F
12-4801 was used in Flow cytometry/Cell sorting to reveal a crucial role for IMs in maintaining immune homeostasis in the respiratory tract.
Tue Dec 01 00:00:00 EST 2009
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.
The Journal of clinical investigation
Chou MY,Fogelstrand L,Hartvigsen K,Hansen LF,Woelkers D,Shaw PX,Choi J,Perkmann T,Bäckhed F,Miller YI,Hörkkö S,Corr M,Witztum JL,Binder CJ
12-4801 was used in Flow cytometry/Cell sorting to propose novel insights into the functions of natural Abs (NAbs) in host health and disease, in particular chronic inflammatory diseases such as atherosclerosis.
Fri May 01 00:00:00 EDT 2009
Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site.
Cancer research
Li B,Vincent A,Cates J,Brantley-Sieders DM,Polk DB,Young PP
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of TNF-alpha in endothelial differentiation of myeloid progenitors in tumours.
Thu Jan 01 00:00:00 EST 2009
Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.
Molecular therapy : the journal of the American Society of Gene Therapy
Devey L,Ferenbach D,Mohr E,Sangster K,Bellamy CO,Hughes J,Wigmore SJ
12-4801 was used in Flow cytometry/Cell sorting to study ischemia reperfusion injury protection in the liver by tissue-resident macrophages via a heme oxygenase-1-dependent mechanism.
Thu Jan 01 00:00:00 EST 2009
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice.
Diabetes
Parker MJ,Xue S,Alexander JJ,Wasserfall CH,Campbell-Thompson ML,Battaglia M,Gregori S,Mathews CE,Song S,Troutt M,Eisenbeis S,Williams J,Schatz DA,Haller MJ,Atkinson MA
12-4801 was used in Flow cytometry/Cell sorting to investigate the use of ATG and GCSF in therapies to reverse overt hyperglycaemia in a diabetic mouse model.
Thu Oct 01 00:00:00 EDT 2009
A possible contribution of retinoids to regulation of fetal B lymphopoiesis.
European journal of immunology
Chen X,Welner RS,Kincade PW
12-4801 was used in Flow cytometry/Cell sorting to determine that retinoids may partially account for rapid differentiation in foetal life, but not for all unique features of foetal progenitors.
Tue Sep 01 00:00:00 EDT 2009
Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro.
Mechanisms of ageing and development
Liang S,Domon H,Hosur KB,Wang M,Hajishengallis G
12-4801 was used in Flow cytometry/Cell sorting to investigate age-dependent expression differences in selected Toll-like and other pattern-recognition receptors, receptors involved in inflammatory amplification, and in transmembrane and intracellular regulators of inflammatory signaling.
Sat Aug 01 00:00:00 EDT 2009
Stimulation of the molecule 4-1BB enhances host defense against Listeria monocytogenes infection in mice by inducing rapid infiltration and activation of neutrophils and monocytes.
Infection and immunity
Lee SC,Ju SA,Sung BH,Heo SK,Cho HR,Lee EA,Kim JD,Lee IH,Park SM,Nguyen QT,Suh JH,Kim BS
12-4801 was used in Immunohistochemistry-immunofluorescence to study the role of tumour necrosis factor receptor family molecule 4-1BB in the stimulation of neutrophils during the early phase of Listeria monocytogenes infection.
Fri May 01 00:00:00 EDT 2009
Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy.
PloS one
Dace DS,Khan AA,Stark JL,Kelly J,Cross AH,Apte RS
12-4801 was used in Flow cytometry/Cell sorting to investigate the conditions contributing to the development of CIDP and related conditions.
Tue Sep 22 00:00:00 EDT 2009
MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
PloS one
Kumamoto Y,Denda-Nagai K,Aida S,Higashi N,Irimura T
12-4801 was used in Immunohistochemistry on frozen tissues to investigate the functional and phenotypic differences between Langerhans and dermal dendritic cells, showing that macrophage galactose-type C-type lectin (MGL) 2 is only expression in dermal dendritic cells, which are sufficient to initiate contact hypersensitivity in vivo.
Thu Aug 06 00:00:00 EDT 2009
Endothelial cells support persistent gammaherpesvirus 68 infection.
PLoS pathogens
Suárez AL,van Dyk LF
12-4801 was used in Magnetic cell separation to investigate the role of endothelial cells in gammaherpesvirus 68 infection.
Fri Sep 12 00:00:00 EDT 2008
Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.
International archives of allergy and immunology
Muralimohan G,Rossi RJ,Vella AT
12-4801 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.
Tue Sep 09 00:00:00 EDT 2008
Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112.
Infection and immunity
Hall JD,Woolard MD,Gunn BM,Craven RR,Taft-Benz S,Frelinger JA,Kawula TH
12-4801 was used in Flow cytometry/Cell sorting to investigate the impact of Francisella tularensis inhalation on host cell repertoire and function in the lung.
Mon Dec 01 00:00:00 EST 2008
Genomic island 2 of Brucella melitensis is a major virulence determinant: functional analyses of genomic islands.
Journal of bacteriology
Rajashekara G,Covert J,Petersen E,Eskra L,Splitter G
12-4801 was used in Flow cytometry/Cell sorting to investigate how the I0999 sequence might function as a transporter to help facilitate the transport or linking of the O antigen to the LPS.
Mon Sep 01 00:00:00 EDT 2008
Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists
Hou Y,Li F,Karin M,Ostrowski MC
12-4801 was used in Flow cytometry/Cell sorting to describe the IKKβ/NF-κB signalling pathway involved in embryonic angiogenesis, which Ikkβ locus disruption in foetal liver vasculature revealed to be responsible for regulation of hepatocyte proliferation and apoptosis, however not for hematopoiesis.
Wed Oct 01 00:00:00 EDT 2008
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
PloS one
Banerjee R,Mosley RL,Reynolds AD,Dhar A,Jackson-Lewis V,Gordon PH,Przedborski S,Gendelman HE
12-4801 was used in Flow cytometry/Cell sorting to investigate the role of T cell immunity in human G93A SOD1 Tg mice and in ALS patients.
Wed Jul 23 00:00:00 EDT 2008
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
The Journal of experimental medicine
Laky K,Fowlkes BJ
12-4801 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.
Mon Sep 03 00:00:00 EDT 2007
Leishmania-derived murine monocyte chemoattractant protein 1 enhances the recruitment of a restrictive population of CC chemokine receptor 2-positive macrophages.
Infection and immunity
Conrad SM,Strauss-Ayali D,Field AE,Mack M,Mosser DM
12-4801 was used in Flow cytometry/Cell sorting to suggests that parasite-derived MCP-1 can recruit a subset of macrophages into lesions that can be stimulated to efficiently kill Leishmania parasites.
Thu Feb 01 00:00:00 EST 2007
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology
Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ
Sat Oct 01 00:00:00 EDT 2005
