Invitrogen

F4/80 Monoclonal Antibody (BM8), PerCP-Cyanine5.5, eBioscience™

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F4/80 Antibody (45-4801-82) in Flow

Staining of mouse resident peritoneal exudate cells with Anti-Mouse CD11b APC (Product # 17-0112-82) and 0.25 µg of Rat IgG2a K Isotype Control PerCP-Cyanine5-5 (Product # 45-4321-80) (left) or 0.25 µg of Anti-Mouse F4/80 Antigen PerCP-Cyanine5-5 (right). Cells in the large scatter population were used for analysis.

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Product Details

45-4801-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Flow Cytometry (Flow)

0.5 µg/test

View 212 publications 212 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Hamster, Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), PerCP-Cyanine5.5, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

BM8

Conjugate

PerCP-Cyanine5.5 PerCP-Cyanine5.5 PerCP-Cyanine5.5

Excitation/Emission Max

489/679 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_914345

Product Specific Information

Description: The BM8 monoclonal antibody reacts with mouse F4/80 antigen, an approximately 160 kDa surface receptor. It belongs to the EGF-TM7 family of proteins. As such it contains seven EGF-like domains on its extracellular N-terminus, seven transmembrane spanning sequences, and an intracellular C-terminal domain showing homology to other TM7 superfamily members. The F4/80 antigen is expressed by a majority of mature macrophages and is one of the best markers for this population of cells. However, other cell types, such as peritoneal eosinophils, Langerhans cells, and some other dendritic cell subtypes, have been reported to express this antigen as well. Expression of F4/80 commences during early myeloid development in vivo and can be upregulated on BM cells stimulated in vitro with M-CSF. Some populations of macrophages, especially in the lymphoid microenvironment, may be devoid of F4/80.

Applications Reported: This BM8 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This BM8 antibody has been tested by flow cytometric analysis of mouse resident peritoneal exudate cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 695 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

F4/80 antigen is a 160 kDa cell surface glycoprotein that is a member of the EGF TM7 family of proteins and shares 68% overall amino acid identity with human EGF module containing mucin like hormone receptor 1 (EMR1). Expression of F4/80 is heterogeneous and is reported to vary during macrophage maturation and activation. The F4/80 antigen is expressed on a wide range of mature tissue macrophages including Kupffer cells, Langerhans, microglia, macrophages located in the gut lamina propria, peritoneal cavity, lung, thymus, bone marrow stroma and macrophages in the red pulp of the spleen. F4/80 expression has also been reported on a subpopulation of dendritic cells but is absent from macrophages located in T cell areas of the spleen and lymph node. The ligands and biological functions of the F4/80 antigen have not yet been determined but recent studies suggest a role for F4/80 in the generation of efferent CD8+ve regulatory T cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.

Redox biology

Tomitsuka Y,Imaeda H,Ito H,Asou I,Ohbayashi M,Ishikawa F,Kuwata H,Hara S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2023

Platelet factors attenuate inflammation and rescue cognition in ageing.

Nature

Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.

iScience

Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Oct 20 00:00:00 EDT 2023

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation.

eLife

Scinicariello S,Soderholm A,Schäfer M,Shulkina A,Schwartz I,Hacker K,Gogova R,Kalis R,Froussios K,Budroni V,Bestehorn A,Clausen T,Kovarik P,Zuber J,Versteeg GA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Mar 24 00:00:00 EDT 2023

Role of low-intensity pulsed ultrasound in regulating macrophage polarization to accelerate tendon-bone interface repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Xu Z,Li S,Wan L,Hu J,Lu H,Zhang T

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2023

A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.

Nature communications

He Y,Ge C,Moreno-Giró À,Xu B,Beusch CM,Sandor K,Su J,Cheng L,Lönnblom E,Lundqvist C,Slot LM,Tong D,Urbonaviciute V,Liang B,Li T,Lahore GF,Aoun M,Malmström V,Rispens T,Ernfors P,Svensson CI,Scherer HU,Toes REM,Gjertsson I,Ekwall O,Zubarev RA,Holmdahl R

45-4801-82 was used in Flow cytometry/Cell sorting to suggest that a subset of anti-citrullinated protein antibodies (ACPAs) have therapeutic potential in rheumatoid arthritis (RA).

Wed Feb 08 00:00:00 EST 2023

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization.

Journal of advanced research

Lee JH,Lee SH,Lee EH,Cho JY,Song DK,Lee YJ,Kwon TK,Oh BC,Cho KW,Osborne TF,Jeon TI,Im SS

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

GPR84 regulates pulmonary inflammation by modulating neutrophil functions.

Acta pharmacologica Sinica

Wang SW,Zhang Q,Lu D,Fang YC,Yan XC,Chen J,Xia ZK,Yuan QT,Chen LH,Zhang YM,Nan FJ,Xie X

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface.

American journal of reproductive immunology (New York, N.Y. : 1989)

An X,Qin J,Hu X,Zhou Y,Fu B,Wei H

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Low-intensity pulsed ultrasound promotes skeletal muscle regeneration via modulating the inflammatory immune microenvironment.

International journal of biological sciences

Qin H,Luo Z,Sun Y,He Z,Qi B,Chen Y,Wang J,Li C,Lin W,Han Z,Zhu Y

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Mar 20 00:00:00 EDT 2023

TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Zhao J,Jia L,Tao Y,Zhao X,Yang J,Lu Y,Yan Y,Mao L,Hu L,Lu J,Guo M,Chen C,Zhou Y,Wen Z,He Z,Xu L

45-4801-82 was used in Flow cytometry/Cell sorting to suggest that the clone selection in thymus in Endotoxin tolerance may confer protection against microbial sepsis.

Wed Mar 01 00:00:00 EST 2023

CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Duan H,Jing L,Xiang J,Ju C,Wu Z,Liu J,Ma X,Chen X,Liu Z,Feng J,Yan X

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Role of circular RNA cdr1as in modulation of macrophage phenotype.

Life sciences

Gonzalez C,Cimini M,Cheng Z,Benedict C,Wang C,Trungcao M,Mallaredy V,Rajan S,Garikipati VNS,Kishore R

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Nov 15 00:00:00 EST 2022

Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.

eLife

Lundahl MLE,Mitermite M,Ryan DG,Case S,Williams NC,Yang M,Lynch RI,Lagan E,Lebre FM,Gorman AL,Stojkovic B,Bracken AP,Frezza C,Sheedy FJ,Scanlan EM,O'Neill LAJ,Gordon SV,Lavelle EC

45-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that activation with IL-4 and IL-13 counterintuitively induces protective innate memory against mycobacterial challenge.

Thu Sep 29 00:00:00 EDT 2022

Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication.

Cell reports

Vu R,Jin S,Sun P,Haensel D,Nguyen QH,Dragan M,Kessenbrock K,Nie Q,Dai X

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2022

PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.

The Journal of experimental medicine

Cheng YW,Zhang ZB,Lan BD,Lin JR,Chen XH,Kong LR,Xu L,Ruan CC,Gao PJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Sep 06 00:00:00 EDT 2021

A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis.

Biomaterials

Keum H,Kim D,Kim J,Kim TW,Whang CH,Jung W,Jon S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Aug 01 00:00:00 EDT 2021

Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.

The EMBO journal

Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Mar 15 00:00:00 EDT 2021

Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases.

Bone research

Polavaram NS,Dutta S,Islam R,Bag AK,Roy S,Poitz D,Karnes J,Hofbauer LC,Kohli M,Costello BA,Jimenez R,Batra SK,Teply BA,Muders MH,Datta K

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri May 14 00:00:00 EDT 2021

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.

Basic research in cardiology

Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Apr 30 00:00:00 EDT 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

45-4801 was used in Flow cytometry/Cell sorting to invetsigate the role of adipocyte-specific Becn1 in adipocyte survival and adipose tissue homeostasis using a lipodystrophy model of mice.

Fri Jan 01 00:00:00 EST 2021

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation.

Diabetes

Jin Y,Ji Y,Song Y,Choe SS,Jeon YG,Na H,Nam TW,Kim HJ,Nahmgoong H,Kim SM,Kim JW,Nam KT,Seong JK,Hwang D,Park CB,Lee IH,Kim JB,Lee HW

45-4801 was used in Flow cytometry/Cell sorting to invetsigate the role of adipocyte-specific Becn1 in adipocyte survival and adipose tissue homeostasis using a lipodystrophy model of mice.

Fri Jan 01 00:00:00 EST 2021

NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation.

Cell proliferation

Chen Y,Yang Q,Lv C,Chen Y,Zhao W,Li W,Chen H,Wang H,Sun W,Yuan H

45-4801-82 was used in Flow Cytometry to reveal that NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation.

Mon Feb 01 00:00:00 EST 2021

Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer.

Cancer science

Zhang GQ,Jiao Q,Shen CT,Song HJ,Zhang HZ,Qiu ZL,Luo QY

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Serum- and Glucocorticoid-Inducible Kinase 1 Promotes Alternative Macrophage Polarization and Restrains Inflammation through FoxO1 and STAT3 Signaling.

Journal of immunology (Baltimore, Md. : 1950)

Ren J,Han X,Lohner H,Liang R,Liang S,Wang H

45-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that SGK1 is critical for macrophage polarization and periodontal bone loss, and to propose a bifurcated signaling circuit by which SGK1 promotes alternative, while suppressing inflammatory, macrophage polarization.

Thu Jul 01 00:00:00 EDT 2021

Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.

Scientific reports

Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon May 24 00:00:00 EDT 2021

Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH.

STAR protocols

Daemen S,Chan MM,Schilling JD

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jun 18 00:00:00 EDT 2021

Generation and utilization of a HEK-293T murine GM-CSF expressing cell line.

PloS one

Robinson EK,Covarrubias S,Zhou S,Carpenter S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Sep 15 00:00:00 EDT 2021

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.

Journal of neuroinflammation

Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Mar 22 00:00:00 EDT 2021

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.

Journal of neuroinflammation

Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Mar 22 00:00:00 EDT 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice.

Frontiers in immunology

Oladiran O,Shi XQ,Fournier S,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Dec 21 00:00:00 EST 2021

Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.

Frontiers in immunology

Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Feb 10 00:00:00 EST 2022

Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi.

Pathogens (Basel, Switzerland)

Medina-Buelvas DM,Rodríguez-Sosa M,Vega L

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Nov 06 00:00:00 EDT 2021

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.

Nature communications

Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N

45-4801-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.

Tue Nov 23 00:00:00 EST 2021

Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.

ACS nano

Ling X,Jiang X,Li Y,Han W,Rodriguez M,Xu Z,Lin W

45-4801-82 was used in flow cytometry to sequential delivery of antiangiogenic and chemotherapeutic agents with bioresponsive NPs activates tumor microenvironments and synergizes with CD40 agonist to regress transplanted tumors and inhibit disseminated tumors in a lung cancer mouse model.

Tue Jan 26 00:00:00 EST 2021

Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.

Nano-micro letters

Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Nov 21 00:00:00 EST 2020

Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis.

Autophagy

Pahari S,Negi S,Aqdas M,Arnett E,Schlesinger LS,Agrewala JN

45-4801-82 was used in Flow Cytometry to invesigate if a unique immunotherapeutic approach involving CLEC4E in conjunction with TLR4 to restrict the survival of mycobacterium tuberculosis through autophagy exists.

Mon Jun 01 00:00:00 EDT 2020

Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells.

Oncogene

Cheng R,Billet S,Liu C,Haldar S,Choudhury D,Tripathi M,Hav M,Merchant A,Hu T,Huang H,Zhou H,Bhowmick NA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Zhao SJ,Liu H,Chen J,Qian DF,Kong FQ,Jie J,Yin GY,Li QQ,Fan J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Neonatal Heart Responds to Pressure Overload With Differential Alterations in Various Cardiomyocyte Maturation Programs That Accommodate Simultaneous Hypertrophy and Hyperplasia.

Frontiers in cell and developmental biology

Ding X,Wang S,Wang Y,Yang J,Bao N,Liu J,Zhang Z

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Dec 18 00:00:00 EST 2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME

45-4801-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.

Sat Feb 01 00:00:00 EST 2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME

Sat Feb 01 00:00:00 EST 2020

Differential Activation of Macrophages Based on Their Environment in Advanced Age.

Chonnam medical journal

Lee DY,Lim JS,Cho KA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.

Scientific reports

Bonfanti AP,Barreto N,Munhoz J,Caballero M,Cordeiro G,Rocha-E-Silva T,Sutti R,Moura F,Brunetto S,Ramos CD,Thomé R,Verinaud L,Rapôso C

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

High-salt diet decreases mechanical thresholds in mice that is mediated by a CCR2-dependent mechanism.

Journal of neuroinflammation

Fan A,Oladiran O,Shi XQ,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

F1000Research

Shiuan E,Inala A,Wang S,Song W,Youngblood V,Chen J,Brantley-Sieders DM

45-4801 was used in Flow cytometry/Cell sorting to study how ephrin-A1 host deficiency affects cancer growth and metastasis in a murine model of breast cancer.

Mon Feb 01 00:00:00 EST 2021

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

F1000Research

Shiuan E,Inala A,Wang S,Song W,Youngblood V,Chen J,Brantley-Sieders DM

45-4801 was used in Flow cytometry/Cell sorting to study how ephrin-A1 host deficiency affects cancer growth and metastasis in a murine model of breast cancer.

Mon Feb 01 00:00:00 EST 2021

MFG-E8 accelerates wound healing in diabetes by regulating "NLRP3 inflammasome-neutrophil extracellular traps" axis.

Cell death discovery

Huang W,Jiao J,Liu J,Huang M,Hu Y,Ran W,Yan L,Xiong Y,Li M,Quan Z,Rao Y,Chen J,Huang Y,Zhang D

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Sep 26 00:00:00 EDT 2023

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer.

Journal of hematology & oncology

Lu CS,Shiau AL,Su BH,Hsu TS,Wang CT,Su YC,Tsai MS,Feng YH,Tseng YL,Yen YT,Wu CL,Shieh GS

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

JCI insight

Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2020

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.

eLife

Kim EH,Woodruff MC,Grigoryan L,Maier B,Lee SH,Mandal P,Cortese M,Natrajan MS,Ravindran R,Ma H,Merad M,Gitlin AD,Mocarski ES,Jacob J,Pulendran B

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Inhibition of Fatty Acid-Binding Protein 4 Attenuated Kidney Fibrosis by Mediating Macrophage-to-Myofibroblast Transition.

Frontiers in immunology

Feng Y,Guo F,Xia Z,Liu J,Mai H,Liang Y,Zhu G,Li Y,Bai L,Li L,Huang R,Shi M,Ma L,Fu P

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Jun 03 00:00:00 EDT 2021

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.

Cells

Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jul 07 00:00:00 EDT 2020

Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.

Nature communications

Yu L,Zhang B,Deochand D,Sacta MA,Coppo M,Shang Y,Guo Z,Zeng X,Rollins DA,Tharmalingam B,Li R,Chinenov Y,Rogatsky I,Hu X

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri May 08 00:00:00 EDT 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.

Cell & bioscience

Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L

45-4801-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.

Sun Apr 17 00:00:00 EDT 2022

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jun 19 00:00:00 EDT 2020

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Nature

Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

CNS neuroscience & therapeutics

Peng J,Wang K,Xiang W,Li Y,Hao Y,Guan Y

45-4801 was used in Flow cytometry/Cell sorting to show rosiglitazone treatment inhibits the proinflammatory polarization of microglia and can rescue neuron loss in the brain after pilocarpine-induced status epilepticus.

Sun Dec 01 00:00:00 EST 2019

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis.

Purinergic signalling

Rothweiler S,Feldbrügge L,Jiang ZG,Csizmadia E,Longhi MS,Vaid K,Enjyoji K,Popov YV,Robson SC

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Sep 01 00:00:00 EDT 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice.

PLoS genetics

Madaro L,Torcinaro A,De Bardi M,Contino FF,Pelizzola M,Diaferia GR,Imeneo G,Bouchè M,Puri PL,De Santa F

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Expression of the Mxra8 Receptor Promotes Alphavirus Infection and Pathogenesis in Mice and Drosophila.

Cell reports

Zhang R,Earnest JT,Kim AS,Winkler ES,Desai P,Adams LJ,Hu G,Bullock C,Gold B,Cherry S,Diamond MS

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Sep 03 00:00:00 EDT 2019

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus.

Frontiers in immunology

Gautam A,Park BK,Kim TH,Akauliya M,Kim D,Maharjan S,Park J,Kim J,Lee H,Park MS,Lee Y,Kwon HJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Aug 17 00:00:00 EDT 2020

Therapeutic ultrasound attenuates DSS-induced colitis through the cholinergic anti-inflammatory pathway.

EBioMedicine

Nunes NS,Chandran P,Sundby M,Visioli F,da Costa Gonçalves F,Burks SR,Paz AH,Frank JA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.

Nature metabolism

Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Critical Illness.

Frontiers in medicine

Hasan S,Johnson MC,Kini AR,Baldea AJ,Muthumalaiappan K

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Nov 03 00:00:00 EST 2020

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

Nature communications

Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Oct 28 00:00:00 EDT 2019

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding.

Journal of translational medicine

Liu C,Li P,Li H,Wang S,Ding L,Wang H,Ye H,Jin Y,Hou J,Fang X,Shu Q

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Sep 02 00:00:00 EDT 2019

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.

Nature communications

Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.

Scientific reports

Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.

Cell death discovery

Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer.

Frontiers in immunology

Martinez LM,Robila V,Clark NM,Du W,Idowu MO,Rutkowski MR,Bos PD

45-4801-82 was used in Flow cytometry/Cell sorting to investigate Treg cell function in the progression from non-invasive to invasive breast cancer lesions.

Tue Sep 29 00:00:00 EDT 2020

HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.

Oncoimmunology

Triulzi T,Forte L,Regondi V,Di Modica M,Ghirelli C,Carcangiu ML,Sfondrini L,Balsari A,Tagliabue E

45-4801 was used in Flow cytometry/Cell sorting to investigate the relationship between HER2 activity and the pro-trastuzumab tumour immune milieu.

Tue Jan 12 00:00:00 EST 2021

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

Nature

Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

Chanzyme TRPM7 Mediates the Ca²⁺ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.

Immunity

Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Apr 02 00:00:00 EDT 2018

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Journal of leukocyte biology

Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.

International journal of obesity (2005)

Chang CJ,Lu CC,Lin CS,Martel J,Ko YF,Ojcius DM,Wu TR,Tsai YH,Yeh TS,Lu JJ,Lai HC,Young JD

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver.

American journal of physiology. Gastrointestinal and liver physiology

Zimmerman KA,Song CJ,Gonzalez-Mize N,Li Z,Yoder BK

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δp66 Borrelia burgdorferi.

Infection and immunity

Curtis MW,Hahn BL,Zhang K,Li C,Robinson RT,Coburn J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.

JCI insight

Barnette DN,Cahill TJ,Gunadasa-Rohling M,Carr CA,Freeman M,Riley PR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Feb 08 00:00:00 EST 2018

Toll-like receptor 2 deficiency hyperactivates the FoxO1 transcription factor and induces aging-associated cardiac dysfunction in mice.

The Journal of biological chemistry

Spurthi KM,Sarikhani M,Mishra S,Desingu PA,Yadav S,Rao S,Maity S,Tamta AK,Kumar S,Majumdar S,Jain A,Raghuraman A,Khan D,Singh I,Samuel RJ,Ramachandra SG,Nandi D,Sundaresan NR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Aug 24 00:00:00 EDT 2018

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1.

The Journal of biological chemistry

Rijal D,Ariana A,Wight A,Kim K,Alturki NA,Aamir Z,Ametepe ES,Korneluk RG,Tiedje C,Menon MB,Gaestel M,McComb S,Sad S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jul 27 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Apr 03 00:00:00 EDT 2018

An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.

Scientific reports

Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Nov 02 00:00:00 EDT 2018

Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.

The Journal of biological chemistry

Hamlin AN,Chinnarasu S,Ding Y,Xian X,Herz J,Jaeschke A,Hui DY

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jun 22 00:00:00 EDT 2018

Characterization of Multiple Cytokine Combinations and TGF-β on Differentiation and Functions of Myeloid-Derived Suppressor Cells.

International journal of molecular sciences

Lee CR,Lee W,Cho SK,Park SG

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Mar 15 00:00:00 EDT 2018

Hypothalamic Macrophage Inducible Nitric Oxide Synthase Mediates Obesity-Associated Hypothalamic Inflammation.

Cell reports

Lee CH,Kim HJ,Lee YS,Kang GM,Lim HS,Lee SH,Song DK,Kwon O,Hwang I,Son M,Byun K,Sung YH,Kim S,Kim JB,Choi EY,Kim YB,Kim K,Kweon MN,Sohn JW,Kim MS

45-4801 was used in Flow cytometry to uncover a critical role for hypothalamic macrophage-expressed inducible nitric oxide synthase in hypothalamic inflammation and abnormal glucose metabolism in cases of overnutrition-induced obesity.

Tue Oct 23 00:00:00 EDT 2018

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression.

Nature communications

Xiang W,Shi R,Kang X,Zhang X,Chen P,Zhang L,Hou A,Wang R,Zhao Y,Zhao K,Liu Y,Ma Y,Luo H,Shang S,Zhang J,He F,Yu S,Gan L,Shi C,Li Y,Yang W,Liang H,Miao H

45-4801 was used in Flow cytometry/Cell sorting to study the effects of a deficiency of monoacylglycerol lipase in tumour-associated macrophages.

Tue Jul 03 00:00:00 EDT 2018

Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy.

Cell stem cell

Lechner AJ,Driver IH,Lee J,Conroy CM,Nagle A,Locksley RM,Rock JR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Jul 06 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.

The Journal of clinical investigation

Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.

The Journal of clinical investigation

Chang SK,Kohlgruber AC,Mizoguchi F,Michelet X,Wolf BJ,Wei K,Lee PY,Lynch L,Duquette D,Ceperuelo-Mallafré V,Banks AS,Brenner MB

45-4801 was used in Flow cytometry/Cell sorting to suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation.

Fri Sep 01 00:00:00 EDT 2017

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

The Journal of experimental medicine

Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Apr 03 00:00:00 EDT 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.

Frontiers in immunology

Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

p40 -Deficient Mice Exhibit Impaired Bacterial Clearance and Enhanced Pro-inflammatory Responses during Salmonella enterica serovar Typhimurium Infection.

Frontiers in immunology

Li Y,Lv M,Su C,Long S,Zhang W,Conway KL,Li W,Xavier RJ,Shi HN

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

CCR2^- and CCR2⁺ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.

Mucosal immunology

Liu J,Xue Y,Dong D,Xiao C,Lin C,Wang H,Song F,Fu T,Wang Z,Chen J,Pan H,Li Y,Cai D,Li Z

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Sep 01 00:00:00 EDT 2017

Evaluation of trained immunity by β-1, 3 (d)-glucan on murine monocytes in vitro and duration of response in vivo.

Immunology and cell biology

Garcia-Valtanen P,Guzman-Genuino RM,Williams DL,Hayball JD,Diener KR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation.

Journal of molecular and cellular cardiology

Lynch TL,Ismahil MA,Jegga AG,Zilliox MJ,Troidl C,Prabhu SD,Sadayappan S

45-4801 was used in Flow cytometry/Cell sorting to show that a robust proinflammatory response occurs in the hearts of mice with dilated cardiomyopathy caused by a mutation in the cardiac myosin binding protein-C gene.

Sun Jan 01 00:00:00 EST 2017

Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria.

Journal of immunology (Baltimore, Md. : 1950)

Li Z,Jiao Y,Fan EK,Scott MJ,Li Y,Li S,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Microarray analysis of circular RNA expression patterns in polarized macrophages.

International journal of molecular medicine

Zhang Y,Zhang Y,Li X,Zhang M,Lv K

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Cancer prevention research (Philadelphia, Pa.)

Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Zoledronic acid inhibits infiltration of tumor-associated macrophages and angiogenesis following transcatheter arterial chemoembolization in rat hepatocellular carcinoma models.

Oncology letters

Zhou DY,Qin J,Huang J,Wang F,Xu GP,Lv YT,Zhang JB,Shen LM

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Phenotypic switch in lung interstitial macrophage polarization in an ovalbumin-induced mouse model of asthma.

Experimental and therapeutic medicine

Nie H,Wang A,He Q,Yang Q,Liu L,Zhang G,Huang Y,Ding X,Yu H,Hu S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.

Scientific reports

Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Jul 31 00:00:00 EDT 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.

eLife

Ku AT,Shaver TM,Rao AS,Howard JM,Rodriguez CN,Miao Q,Garcia G,Le D,Yang D,Borowiak M,Cohen DN,Chitsazzadeh V,Diwan AH,Tsai KY,Nguyen H

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed May 03 00:00:00 EDT 2017

BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.

Scientific reports

Shim DW,Shin WY,Yu SH,Kim BH,Ye SK,Koppula S,Won HS,Kang TB,Lee KH

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 08 00:00:00 EST 2017

Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype.

Cell death & disease

Young CA,Rorke EA,Adhikary G,Xu W,Eckert RL

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation.

Particle and fibre toxicology

Jatana S,Palmer BC,Phelan SJ,Gelein R,DeLouise LA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Apr 14 00:00:00 EDT 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Sep 18 00:00:00 EDT 2017

Exercise training enhances in vivo clearance of endotoxin and attenuates inflammatory responses by potentiating Kupffer cell phagocytosis.

Scientific reports

Komine S,Akiyama K,Warabi E,Oh S,Kuga K,Ishige K,Togashi S,Yanagawa T,Shoda J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Sep 20 00:00:00 EDT 2017

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

JCI insight

Sato-Kaneko F,Yao S,Ahmadi A,Zhang SS,Hosoya T,Kaneda MM,Varner JA,Pu M,Messer KS,Guiducci C,Coffman RL,Kitaura K,Matsutani T,Suzuki R,Carson DA,Hayashi T,Cohen EE

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Sep 21 00:00:00 EDT 2017

IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.

Cell reports

Spadaro O,Camell CD,Bosurgi L,Nguyen KY,Youm YH,Rothlin CV,Dixit VD

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Apr 11 00:00:00 EDT 2017

Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.

Frontiers in cellular and infection microbiology

Ahmed N,French T,Rausch S,Kühl A,Hemminger K,Dunay IR,Steinfelder S,Hartmann S

45-4801 was used in Flow cytometry/Cell sorting to conclude a previous T. gondii infection limits a helminth-specific Th2 immune response while promoting a shift toward a Th1-type immune response.

Mon Apr 02 00:00:00 EDT 2018

The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.

Oncoimmunology

Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M

45-4801 was used in Flow cytometry/Cell sorting to genetically investigate the role of the interleukin-1 receptor 1 pathway in breast cancer tumourigenesis and metastasis using a mouse model.

Tue Jan 12 00:00:00 EST 2021

Targeting phosphorylation of STAT3 delays tumor growth in HPV-negative anal squamous cell carcinoma mouse model.

Scientific reports

Bu LL,Li YC,Yu GT,Liu JF,Deng WW,Zhang WF,Zhang L,Sun ZJ

45-4801 was used in Flow cytometry/Cell sorting to conclude that S3I-201 may be a novel therapeutic approach for HPV-negative anal squamous cell carcinoma patients.

Wed Jul 26 00:00:00 EDT 2017

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.

Immunity

Tian Y,Kuo CF,Akbari O,Ou JH

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue May 17 00:00:00 EDT 2016

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.

Cancer discovery

Lee KE,Spata M,Bayne LJ,Buza EL,Durham AC,Allman D,Vonderheide RH,Simon MC

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression.

Hypertension (Dallas, Tex. : 1979)

Wang H,Hou L,Kwak D,Fassett J,Xu X,Chen A,Chen W,Blazar BR,Xu Y,Hall JL,Ge JB,Bache RJ,Chen Y

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4.

Frontiers in immunology

Zhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L

45-4801 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease.

Wed Mar 16 00:00:00 EDT 2022

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer.

Oncogene

Das S,Rachagani S,Sheinin Y,Smith LM,Gurumurthy CB,Roy HK,Batra SK

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu May 19 00:00:00 EDT 2016

A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.

Mucosal immunology

Dagenais M,Dupaul-Chicoine J,Champagne C,Skeldon A,Morizot A,Saleh M

45-4801 was used in Immunofluorescence-paraffin to investigate the function of cellular inhibitors of apoptosis proteins in intestinal cancer and mechanisms in disease pathogenesis.

Fri Jan 01 00:00:00 EST 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Lineage tracing of cells involved in atherosclerosis.

Atherosclerosis

Albarrán-Juárez J,Kaur H,Grimm M,Offermanns S,Wettschureck N

45-4801 was used in Flow cytometry/Cell sorting to identify the origin of vascular smooth muscle cells and macrophages within atherosclerosis lesions.

Mon Aug 01 00:00:00 EDT 2016

Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD.

Journal of lipid research

Chattopadhyay A,Navab M,Hough G,Grijalva V,Mukherjee P,Fogelman HR,Hwang LH,Faull KF,Lusis AJ,Reddy ST,Fogelman AM

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.

Journal of leukocyte biology

Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

Disease models & mechanisms

Chu CJ,Gardner PJ,Copland DA,Liyanage SE,Gonzalez-Cordero A,Kleine Holthaus SM,Luhmann UF,Smith AJ,Ali RR,Dick AD

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma.

Bone

Pagnotti GM,Chan ME,Adler BJ,Shroyer KR,Rubin J,Bain SD,Rubin CT

45-4801 was used in Flow cytometry/Cell sorting to evaluate whether low-intensity vibration can protect bone and bone marrow during myeloma progression.

Thu Sep 01 00:00:00 EDT 2016

Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma.

Bone

Pagnotti GM,Chan ME,Adler BJ,Shroyer KR,Rubin J,Bain SD,Rubin CT

45-4801 was used in Flow cytometry/Cell sorting to evaluate whether low-intensity vibration can protect bone and bone marrow during myeloma progression.

Thu Sep 01 00:00:00 EDT 2016

PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.

Cell death & disease

Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Apr 07 00:00:00 EDT 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Macrophages form functional vascular mimicry channels in vivo.

Scientific reports

Barnett FH,Rosenfeld M,Wood M,Kiosses WB,Usui Y,Marchetti V,Aguilar E,Friedlander M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Nov 11 00:00:00 EST 2016

Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.

Scientific reports

Cousins FL,Kirkwood PM,Saunders PT,Gibson DA

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Nov 09 00:00:00 EST 2016

L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo.

BMC cancer

Cao Y,Feng Y,Zhang Y,Zhu X,Jin F

45-4801 was used in Flow cytometry/Cell sorting to study the effects of L-Arg treatment on inhibition of tumour growth and immunological function.

Wed Jun 01 00:00:00 EDT 2016

Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma.

Oncoimmunology

Bu LL,Yu GT,Deng WW,Mao L,Liu JF,Ma SR,Fan TF,Hall B,Kulkarni AB,Zhang WF,Sun ZJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

Scientific reports

Li SX,Barrett BS,Guo K,Kassiotis G,Hasenkrug KJ,Dittmer U,Gibbert K,Santiago ML

45-4801 was used in Flow cytometry/Cell sorting to investigate the role of Tetherin in counteracting retrovirus replication in vivo.

Fri Feb 05 00:00:00 EST 2016

Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity.

JCI insight

Sassmann-Schweda A,Singh P,Tang C,Wietelmann A,Wettschureck N,Offermanns S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu May 19 00:00:00 EDT 2016

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.

Journal of translational medicine

De Cesare M,Sfondrini L,Pennati M,De Marco C,Motta V,Tagliabue E,Deraco M,Balsari A,Zaffaroni N

45-4801 was used in Flow cytometry/Cell sorting to indicate that locally administered CpG-ODN1826 is able to markedly affect the growth of both early- and late-stage DMPM orthotopic xenografts in the absence of severe side effects.

Mon Jan 25 00:00:00 EST 2016

ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.

eLife

Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F

45-4801 was used in Flow cytometry/Cell sorting to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.

Mon Jan 18 00:00:00 EST 2016

Targeting CD73 in the tumor microenvironment with MEDI9447.

Oncoimmunology

Hay CM,Sult E,Huang Q,Mulgrew K,Fuhrmann SR,McGlinchey KA,Hammond SA,Rothstein R,Rios-Doria J,Poon E,Holoweckyj N,Durham NM,Leow CC,Diedrich G,Damschroder M,Herbst R,Hollingsworth RE,Sachsenmeier KF

45-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism of action of MEDI9447 in the tumour microenvironment.

Mon Aug 01 00:00:00 EDT 2016

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.

Scientific reports

Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Jun 02 00:00:00 EDT 2016

Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice.

Scientific reports

Dou GR,Li N,Chang TF,Zhang P,Gao X,Yan XC,Liang L,Han H,Wang YS

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jun 24 00:00:00 EDT 2016

Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner.

Immunity, inflammation and disease

Owusu-Boaitey N,Bauckman KA,Zhang T,Mysorekar IU

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Suppression of Protective Responses upon Activation of L-Type Voltage Gated Calcium Channel in Macrophages during Mycobacterium bovis BCG Infection.

PloS one

Sharma D,Tiwari BK,Mehto S,Antony C,Kak G,Singh Y,Natarajan K

45-4801 was used in Magnetic cell separation to demonstrate a well-orchestrated strategy adopted by mycobacteria to supress protective responses mounted by the host.

Fri Apr 28 00:00:00 EDT 2017

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Nature medicine

Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Host microbiota constantly control maturation and function of microglia in the CNS.

Nature neuroscience

Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation.

Blood

Nair S,Boddupalli CS,Verma R,Liu J,Yang R,Pastores GM,Mistry PK,Dhodapkar MV

45-4801 was used in Flow cytometry/Cell sorting to identify a type II NKT-mediated pathway for glucosphingolipid-mediated dysregulation of humoral immunity and increased risk of B-cell malignancy seen in metabolic lipid disorders.

Thu Feb 19 00:00:00 EST 2015

Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation.

Blood

Nair S,Boddupalli CS,Verma R,Liu J,Yang R,Pastores GM,Mistry PK,Dhodapkar MV

Thu Feb 19 00:00:00 EST 2015

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

The Journal of clinical investigation

Ying W,Tseng A,Chang RC,Morin A,Brehm T,Triff K,Nair V,Zhuang G,Song H,Kanameni S,Wang H,Golding MC,Bazer FW,Chapkin RS,Safe S,Zhou B

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2015

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.

Autophagy

Choi SH,Gonen A,Diehl CJ,Kim J,Almazan F,Witztum JL,Miller YI

45-4801 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms by which SYK regulates MHC-II expression via autophagy in macrophages.

Tue Feb 23 00:00:00 EST 2016

SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL.

Autophagy

Choi SH,Gonen A,Diehl CJ,Kim J,Almazan F,Witztum JL,Miller YI

45-4801 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms by which SYK regulates MHC-II expression via autophagy in macrophages.

Tue Feb 23 00:00:00 EST 2016

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Jul 10 00:00:00 EDT 2015

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

eLife

Freedman TS,Tan YX,Skrzypczynska KM,Manz BN,Sjaastad FV,Goodridge HS,Lowell CA,Weiss A

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Oct 30 00:00:00 EDT 2015

Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism.

Stem cells translational medicine

Morris ME,Beare JE,Reed RM,Dale JR,LeBlanc AJ,Kaufman CL,Zheng H,Ng CK,Williams SK,Hoying JB

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury.

Journal of leukocyte biology

Hwaiz R,Rahman M,Syk I,Zhang E,Thorlacius H

45-4801 was used in Flow cytometry/Cell sorting to assess the role of platelet-derived CCL5 in facilitating sepsis-induced neutrophil accumulation in the lung.

Fri May 01 00:00:00 EDT 2015

Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease.

Disease models & mechanisms

Williams BB,Tebbutt NC,Buchert M,Putoczki TL,Doggett K,Bao S,Johnstone CN,Masson F,Hollande F,Burgess AW,Scott AM,Ernst M,Heath JK

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2015

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.

International journal of obesity (2005)

Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2015

Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.

Journal of immunology (Baltimore, Md. : 1950)

Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S

45-4801 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.

Sat Aug 01 00:00:00 EDT 2015

Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.

Journal of immunology (Baltimore, Md. : 1950)

Cabrera-Perez J,Condotta SA,James BR,Kashem SW,Brincks EL,Rai D,Kucaba TA,Badovinac VP,Griffith TS

45-4801 was used in Flow cytometry/Cell sorting to demonstrate that the recovery of CD4 T cells from sepsis-induced lymphopenia is accompanied by alterations to the composition and function of the Ag-specific CD4 T cell repertoire.

Sun Feb 15 00:00:00 EST 2015

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice.

Endocrinology

Schoiswohl G,Stefanovic-Racic M,Menke MN,Wills RC,Surlow BA,Basantani MK,Sitnick MT,Cai L,Yazbeck CF,Stolz DB,Pulinilkunnil T,O'Doherty RM,Kershaw EE

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2015

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Keswani RK,Yoon GS,Sud S,Stringer KA,Rosania GR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.

American journal of physiology. Renal physiology

Yuan A,Lee Y,Choi U,Moeckel G,Karihaloo A

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia.

Tissue engineering. Part A

Anderson EM,Kwee BJ,Lewin SA,Raimondo T,Mehta M,Mooney DJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection.

Infection and immunity

Zhan R,Han Q,Zhang C,Tian Z,Zhang J

45-4801 was used in Flow cytometry/Cell sorting to investigate the roles of TLR2 and TLR9 in regulating innate immunity against oral infection of Salmonella enterica serovar Typhimurium in mice.

Wed Apr 01 00:00:00 EDT 2015

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.

BioMed research international

Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Mar 18 00:00:00 EDT 2016

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.

PloS one

Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Apr 28 00:00:00 EDT 2016

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.

Oncoimmunology

Le Noci V,Tortoreto M,Gulino A,Storti C,Bianchi F,Zaffaroni N,Tripodo C,Tagliabue E,Balsari A,Sfondrini L

45-4801 was used in Flow cytometry/Cell sorting to evaluated aerosol delivery CpG-ODN combined with Poly(I:C) in the treatment of B16 melanoma lung metastases in C57BL/6 mice.

Thu Oct 01 00:00:00 EDT 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Nature communications

Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Jun 24 00:00:00 EDT 2015

Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.

Nature communications

Kim AY,Park YJ,Pan X,Shin KC,Kwak SH,Bassas AF,Sallam RM,Park KS,Alfadda AA,Xu A,Kim JB

45-4801 was used in Flow cytometry/Cell sorting to highlight a critical role of adiponectin gene epigenetic control by DNMT1 in governing energy homeostasis.

Fri Jul 03 00:00:00 EDT 2015

Structure-based programming of lymph-node targeting in molecular vaccines.

Nature

Liu H,Moynihan KD,Zheng Y,Szeto GL,Li AV,Huang B,Van Egeren DS,Park C,Irvine DJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Mar 27 00:00:00 EDT 2014

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Nature

Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Sep 25 00:00:00 EDT 2014

A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.

Cell metabolism

Hernandez ED,Lee SJ,Kim JY,Duran A,Linares JF,Yajima T,Müller TD,Tschöp MH,Smith SR,Diaz-Meco MT,Moscat J

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Miscellaneous

Tue Sep 02 00:00:00 EDT 2014

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Nature immunology

Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Apr 01 00:00:00 EDT 2014

Macrophages contribute to the cyclic activation of adult hair follicle stem cells.

PLoS biology

Castellana D,Paus R,Perez-Moreno M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2014

Expression of suppressor of cytokine signaling 1 (SOCS1) impairs viral clearance and exacerbates lung injury during influenza infection.

PLoS pathogens

Sun K,Salmon S,Yajjala VK,Bauer C,Metzger DW

45-4801 was used in Flow cytometry/Cell sorting to determine whether SOCS1 regulates antiviral immunity in vivo by generating SOCS1-/-IFN-γ-/- mice.

Mon Dec 01 00:00:00 EST 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

The plexin C1 receptor promotes acute inflammation.

European journal of immunology

König K,Marth L,Roissant J,Granja T,Jennewein C,Devanathan V,Schneider M,Köhler D,Zarbock A,Rosenberger P

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Sep 01 00:00:00 EDT 2014

Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.

Stem cells (Dayton, Ohio)

Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Little MC,Hurst RJ,Else KJ

45-4801 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.

Sat Nov 01 00:00:00 EDT 2014

Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.

Journal of immunology (Baltimore, Md. : 1950)

Bryant J,Lerret NM,Wang JJ,Kang HK,Tasch J,Zhang Z,Luo X

45-4801 was used in Flow cytometry/Cell sorting to investigate the role of MDSCs in the graft protection provided by ECDI-SPs, showing that preemptive donor apoptotic cell infusions induce IFN-γ-producing MDSCs.

Sun Jun 15 00:00:00 EDT 2014

Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation.

PloS one

Karpurapu M,Ranjan R,Deng J,Chung S,Lee YG,Xiao L,Nirujogi TS,Jacobson JR,Park GY,Christman JW

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jan 20 00:00:00 EST 2015

Niacin reverses migratory macrophage foam cell arrest mediated by oxLDL in vitro.

PloS one

Huang H,Koelle P,Fendler M,Schroettle A,Czihal M,Hoffmann U,Kuhlencordt PJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Dec 17 00:00:00 EST 2015

STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.

Nature communications

Zhang H,Hu H,Greeley N,Jin J,Matthews AJ,Ohashi E,Caetano MS,Li HS,Wu X,Mandal PK,McMurray JS,Moghaddam SJ,Sun SC,Watowich SS

45-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism by which STAT3 curbs pro-inflammatory cytokine production mediated by NF-κB signalling, showing that it restrains signalling by suppressing expression of Ubc13.

Mon Dec 15 00:00:00 EST 2014

The monocyte to macrophage transition in the murine sterile wound.

PloS one

Crane MJ,Daley JM,van Houtte O,Brancato SK,Henry WL,Albina JE

45-4801 was used in Flow cytometry/Cell sorting to examine the origin of wound repair macrophages in sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in mice.

Tue Nov 04 00:00:00 EST 2014

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

Modular 'click-in-emulsion' bone-targeted nanogels.

Advanced materials (Deerfield Beach, Fla.)

Heller DA,Levi Y,Pelet JM,Doloff JC,Wallas J,Pratt GW,Jiang S,Sahay G,Schroeder A,Schroeder JE,Chyan Y,Zurenko C,Querbes W,Manzano M,Kohane DS,Langer R,Anderson DG

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Wed Mar 13 00:00:00 EDT 2013

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Blood

Franke K,Kalucka J,Mamlouk S,Singh RP,Muschter A,Weidemann A,Iyengar V,Jahn S,Wieczorek K,Geiger K,Muders M,Sykes AM,Poitz DM,Ripich T,Otto T,Bergmann S,Breier G,Baretton G,Fong GH,Greaves DR,Bornstein S,Chavakis T,Fandrey J,Gassmann M,Wielockx B

45-4801 was used in Flow cytometry/Cell sorting to study the regulatory effects of oxygen-sensitive prolyl hydroxylases on the process of erythropoiesis.

Thu Feb 21 00:00:00 EST 2013

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.

The Journal of experimental medicine

Molofsky AB,Nussbaum JC,Liang HE,Van Dyken SJ,Cheng LE,Mohapatra A,Chawla A,Locksley RM

45-4801 was used in Flow cytometry/Cell sorting to study how ILC2s are resident in visceral adipose tissue and promote eosinophils and alternatively activated macrophages, implicated in metabolic homeostasis.

Mon Mar 11 00:00:00 EDT 2013

Dose-dense chemotherapy improves mechanisms of antitumor immune response.

Cancer research

Chang CL,Hsu YT,Wu CC,Lai YZ,Wang C,Yang YC,Wu TC,Hung CF

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

S-layer protein mediates the stimulatory effect of Lactobacillus helveticus MIMLh5 on innate immunity.

Applied and environmental microbiology

Taverniti V,Stuknyte M,Minuzzo M,Arioli S,De Noni I,Scabiosi C,Cordova ZM,Junttila I,Hämäläinen S,Turpeinen H,Mora D,Karp M,Pesu M,Guglielmetti S

45-4801 was used in Flow cytometry/Cell sorting to demonstrate the potential for L. helveticus surface-layer protein A to induce the host's defences against infections.

Fri Feb 01 00:00:00 EST 2013

Dietary oleic acid increases m2 macrophages in the mesenteric adipose tissue.

PloS one

Camell C,Smith CW

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon May 12 00:00:00 EDT 2014

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.

Blood

He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Oct 11 00:00:00 EDT 2012

Induction of autophagy is essential for monocyte-macrophage differentiation.

Blood

Zhang Y,Morgan MJ,Chen K,Choksi S,Liu ZG

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Mar 22 00:00:00 EDT 2012

A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade.

Molecular therapy : the journal of the American Society of Gene Therapy

Agudo J,Ruzo A,Kitur K,Sachidanandam R,Blander JM,Brown BD

45-4801 was used in Flow cytometry/Cell sorting to characterise the transient innate immune reaction to lentiviral vector, and evaluate a means for its prevention during LV-mediated gene transfer.

Sat Dec 01 00:00:00 EST 2012

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Dalli J,Jones CP,Cavalcanti DM,Farsky SH,Perretti M,Rankin SM

45-4801 was used in Immunohistochemistry to identify a role of the anti-inflammatory molecule annexin A1 in the regulation of CXCR4(hi) neutrophil migration to bone marrow.

Sun Jan 01 00:00:00 EST 2012

Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanisms.

The American journal of pathology

Ninković J,Roy S

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

Effect of the poly(ethylene glycol) (PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration.

Molecular pharmaceutics

Zhan X,Tran KK,Shen H

45-4801 was used in Flow cytometry/Cell sorting to study the effect of PEGylation on the lymphatic trafficking and accumulation of particles in draining lymph nodes.

Mon Dec 03 00:00:00 EST 2012

Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis.

Toxicological sciences : an official journal of the Society of Toxicology

Beamer CA,Seaver BP,Shepherd DM

45-4801 was used in Flow cytometry/Cell sorting to investigate the numerous physiological roles of the aryl hydrocarbon receptor using a mouse model.

Sun Apr 01 00:00:00 EDT 2012

Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice.

Biology of sex differences

Roberts BJ,Dragon JA,Moussawi M,Huber SA

45-4801 was used in Flow cytometry/Cell sorting to determine which TLRs show differential expression in CVB3 infected mice corresponding to male susceptibility and female resistance in Coxsackievirus B3.

Sat Dec 15 00:00:00 EST 2012

An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.

PloS one

Bongfen SE,Rodrigue-Gervais IG,Berghout J,Torre S,Cingolani P,Wiltshire SA,Leiva-Torres GA,Letourneau L,Sladek R,Blanchette M,Lathrop M,Behr MA,Gruenheid S,Vidal SM,Saleh M,Gros P

45-4801 was used in Flow cytometry/Cell sorting to identify host proteins involved in cerebral malaria pathogenesis.

Fri Jun 29 00:00:00 EDT 2012

The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury.

PloS one

König K,Köhler D,Granja T,Jennewein C,Tran N,Mirakaj V,Kröhnert F,Rosenberger P

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Apr 02 00:00:00 EDT 2013

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain.

Journal of neuroinflammation

Howe CL,Lafrance-Corey RG,Sundsbak RS,Lafrance SJ

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Mar 09 00:00:00 EST 2012

PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis.

PloS one

Comerford I,Litchfield W,Kara E,McColl SR

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Feb 26 00:00:00 EST 2013

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.

Blood

Cudejko C,Wouters K,Fuentes L,Hannou SA,Paquet C,Bantubungi K,Bouchaert E,Vanhoutte J,Fleury S,Remy P,Tailleux A,Chinetti-Gbaguidi G,Dombrowicz D,Staels B,Paumelle R

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2011

DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity.

Journal of immunology (Baltimore, Md. : 1950)

Guerriero JL,Ditsworth D,Catanzaro JM,Sabino G,Furie MB,Kew RR,Crawford HC,Zong WX

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Mar 15 00:00:00 EDT 2011

Myeloid cells migrate in response to IL-24.

Cytokine

Buzas K,Oppenheim JJ,Zack Howard OM

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2011

Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344.

PloS one

Xie P,Kamei M,Suzuki M,Matsumura N,Nishida K,Sakimoto S,Sakaguchi H,Nishida K

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Mon Apr 23 00:00:00 EDT 2012

Loss of negative feedback control of nuclear factor-kappaB2 activity in lymphocytes leads to fatal lung inflammation.

The American journal of pathology

Yang L,Cui H,Wang Z,Zhang B,Ding J,Liu L,Ding HF

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2010

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.

Nature immunology

Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M

Published figure using F4/80 monoclonal antibody (Product # 45-4801-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2008

Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.

Journal of leukocyte biology

Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ

Sat Oct 01 00:00:00 EDT 2005

Bioinformatics

Protein Aliases: Adhesion G protein-coupled receptor E1; Cell surface glycoprotein F4/80; EGF-like module containing, mucin-like, hormone receptor-like sequence 1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; lymphocyte antigen 71

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Gene Aliases: Adgre1; DD7A5-7; EGF-TM7; Emr1; F4/80; Gpf480; Ly71; TM7LN3

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UniProt ID: (Mouse) Q61549

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Entrez Gene ID: (Mouse) 13733

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Function(s)

signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity calcium ion binding G-protein coupled receptor

Process(es)

signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway

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F4/80 Monoclonal Antibody (BM8), PerCP-Cyanine5.5, eBioscience™

F4/80 Antibody (45-4801-82) in Flow

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45-4801-82

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Immunohistochemistry (Frozen) (IHC (F))

Flow Cytometry (Flow)

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