Product References
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.
Nature
Pernet E,Sun S,Sarden N,Gona S,Nguyen A,Khan N,Mawhinney M,Tran KA,Chronopoulos J,Amberkar D,Sadeghi M,Grant A,Wali S,Prevel R,Ding J,Martin JG,Thanabalasuriar A,Yipp BG,Barreiro LB,Divangahi M
47-4801-82 was used in Flow cytometry/Cell sorting to highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal.
Wed Feb 01 00:00:00 EST 2023
Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.
Nature
Schaefer-Babajew D,Wang Z,Muecksch F,Cho A,Loewe M,Cipolla M,Raspe R,Johnson B,Canis M,DaSilva J,Ramos V,Turroja M,Millard KG,Schmidt F,Witte L,Dizon J,Shimeliovich I,Yao KH,Oliveira TY,Gazumyan A,Gaebler C,Bieniasz PD,Hatziioannou T,Caskey M,Nussenzweig MC
47-4801-82 was used in Flow cytometry/Cell sorting to indicate that pre-existing high-affinity antibodies bias germinal centre and memory B cell selection through two distinct mechanisms: (1) by lowering the activation threshold for B cells, thereby permitting abundant lower-affinity clones to participate in the immune response; and (2) through direct masking of their cognate epitopes.
Sun Jan 01 00:00:00 EST 2023
Continuous germinal center invasion contributes to the diversity of the immune response.
Cell
Hägglöf T,Cipolla M,Loewe M,Chen ST,Mesin L,Hartweger H,ElTanbouly MA,Cho A,Gazumyan A,Ramos V,Stamatatos L,Oliveira TY,Nussenzweig MC,Viant C
47-4801-82 was used in Flow cytometry/Cell sorting to show that naive B cells continuously enter GCs where they compete for T cell help and undergo clonal expansion.
Thu Jan 05 00:00:00 EST 2023
SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models.
Clinical & translational immunology
Synn CB,Kim SE,Lee HK,Kim MH,Kim JH,Lee JM,Jo HN,Lee W,Kim DK,Byeon Y,Kim YS,Yun MR,Park CW,Yun J,Lim S,Heo SG,Yang SD,Lee EJ,Lee S,Choi H,Lee YW,Cho JS,Kim DH,Park S,Kim JH,Choi Y,Lee SS,Ahn BC,Kim CG,Lim SM,Hong MH,Kim HR,Pyo KH,Cho BC
47-4801-82 was used in Flow Cytometry to evaluate the anti-tumor and anti-metastatic activities of SKI-G-801, a small-molecule inhibitor of AXL, alone and in combination with anti-PD-1 therapy.
Fri Apr 29 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
47-4801-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Bifidobacterium longum Ameliorates Ovariectomy-Induced Bone Loss via Enhancing Anti-Osteoclastogenic and Immunomodulatory Potential of Regulatory B Cells (Bregs).
Frontiers in immunology
Sapra L,Shokeen N,Porwal K,Saini C,Bhardwaj A,Mathew M,Mishra PK,Chattopadhyay N,Dar HY,Verma B,Srivastava RK
47-4801-82 was used in Enzyme-linked immunosorbent assay to establish a novel osteo-protective and immunomodulatory potential of BL in augmenting bone health under osteoporotic conditions.
Tue Jun 14 00:00:00 EDT 2022
Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.
The EMBO journal
Wang X,Ray R,Kratochvil S,Melzi E,Lin YC,Giguere S,Xu L,Warner J,Cheon D,Liguori A,Groschel B,Phelps N,Adachi Y,Tingle R,Wu L,Crotty S,Kirsch KH,Nair U,Schief WR,Batista FD
47-4801 was used in Flow cytometry/Cell sorting to report a one-step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.
Fri Jan 15 00:00:00 EST 2021
Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour.
Nature communications
Jeong SH,Yang MJ,Choi S,Kim J,Koh GY
47-4801-82 was used in Flow cytometry/Cell sorting to investigate Stimulator of Interferon Genes (STING) therapy in anti-tumour immunity.
Tue Jul 20 00:00:00 EDT 2021
Expanded renal lymphatics improve recovery following kidney injury.
Physiological reports
Baranwal G,Creed HA,Black LM,Auger A,Quach AM,Vegiraju R,Eckenrode HE,Agarwal A,Rutkowski JM
47-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that increased lymphatic density prior to injury alters the injury recovery response and affords protection from CKD progression.
Mon Nov 01 00:00:00 EDT 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
47-4801-82 was used in Flow Cytometry to analyze the BCRs of different mouse B cell populations for somatic hypermutations, clonal and phylogenic relationships, and their affinity for cognate antigen.
Fri Jun 18 00:00:00 EDT 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
47-4801-82 was used in Flow Cytometry to demonstrate homotypic and heterotypic conjugation of 8 different hemagglutinin trimers.
Fri Oct 15 00:00:00 EDT 2021
Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution.
Nature communications
Lima LG,Ham S,Shin H,Chai EPZ,Lek ESH,Lobb RJ,Müller AF,Mathivanan S,Yeo B,Choi Y,Parker BS,Möller A
47-4801-82 was used in Flow Cytometry to show that microenvironmental cytokines, particularly CCL2, decorate cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs.
Thu Jun 10 00:00:00 EDT 2021
Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution.
Nature communications
Lima LG,Ham S,Shin H,Chai EPZ,Lek ESH,Lobb RJ,Müller AF,Mathivanan S,Yeo B,Choi Y,Parker BS,Möller A
47-4801-82 was used in Flow Cytometry to show that microenvironmental cytokines, particularly CCL2, decorate cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs.
Thu Jun 10 00:00:00 EDT 2021
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
47-4801-82 was used in Flow Cytometry to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 EST 2021
T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.
Nature immunology
Jain A,Irizarry-Caro RA,McDaniel MM,Chawla AS,Carroll KR,Overcast GR,Philip NH,Oberst A,Chervonsky AV,Katz JD,Pasare C
47-4801 was used in Flow cytometry/Cell sorting to describe an inflammasome-independent pathway of IL-1β production that was triggered upon cognate interactions between effector CD4+ T cells and mononuclear phagocytes.
Wed Jan 01 00:00:00 EST 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
47-4801 was used in Flow cytometry/Cell sorting to investigate the impact of the ability of Toxoplasma gondii injecting the rhoptry kinase ROP16 into host cells on infection.
Mon Mar 02 00:00:00 EST 2020
B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.
Cell reports
Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z
47-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that T cell-derived help to B cells in PPs includes SAP-dependent and SAP-independent functions.
Tue Feb 11 00:00:00 EST 2020
L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
Cells
Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC
47-4801 was used in Flow cytometry/Cell sorting to investigate the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis.
Wed Apr 29 00:00:00 EDT 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
47-4801-82 was used in Flow Cytometry to develop an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1 to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires.
Sat Jun 01 00:00:00 EDT 2019
Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Cell
Gauthier L,Morel A,Anceriz N,Rossi B,Blanchard-Alvarez A,Grondin G,Trichard S,Cesari C,Sapet M,Bosco F,Rispaud-Blanc H,Guillot F,Cornen S,Roussel A,Amigues B,Habif G,Caraguel F,Arrufat S,Remark R,Romagné F,Morel Y,Narni-Mancinelli E,Vivier E
47-4801 was used in Flow cytometry/Cell sorting to study a new generation of anti-cancer trifunctional natural killer cell engagers (NKCEs) that target activating receptors NKp46 and CD16.
Thu Jun 13 00:00:00 EDT 2019
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
47-4801-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 EST 2019
Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion.
Cell host & microbe
Thanabalasuriar A,Scott BNV,Peiseler M,Willson ME,Zeng Z,Warrener P,Keller AE,Surewaard BGJ,Dozier EA,Korhonen JT,Cheng LI,Gadjeva M,Stover CK,DiGiandomenico A,Kubes P
47-4801 was used in Flow cytometry/Cell sorting to conclude that blocking both Psl and T3SS together with antibiotic treatment broke down the biofilm and reversed keratitis, suggesting future therapeutic strategies for this intractable infection.
Wed Apr 10 00:00:00 EDT 2019
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.
Nature communications
Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G
47-4801-82 was used in Flow Cytometry to demonstrate that respiratory complex I-deficient tumours survive and carry out angiogenesis, despite their inability to stabilise Hypoxia Inducible Factor-1 alpha.
Fri Feb 22 00:00:00 EST 2019
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
Nature
Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS
47-4801-82 was used in Flow Cytometry to reveal a SLC program that is activated during efferocytosis, identify a previously unknown reliance on aerobic glycolysis during apoptotic cell uptake and show that glycolytic by-products of efferocytosis can influence surrounding cells.
Thu Nov 01 00:00:00 EDT 2018
Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.
The Journal of clinical investigation
Lau A,Chung H,Komada T,Platnich JM,Sandall CF,Choudhury SR,Chun J,Naumenko V,Surewaard BG,Nelson MC,Ulke-Lemée A,Beck PL,Benediktsson H,Jevnikar AM,Snelgrove SL,Hickey MJ,Senger DL,James MT,Macdonald JA,Kubes P,Jenne CN,Muruve DA
47-4801 was used in Flow cytometry/Cell sorting to show that CI-AKI is a multistep process that involves immune surveillance by resident and infiltrating renal phagocytes, Nlrp3-dependent inflammation, and the tubular reabsorption of contrast via dipeptidase-1.
Mon Jul 02 00:00:00 EDT 2018
Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.
Scientific reports
Osum KC,Burrack AL,Martinov T,Sahli NL,Mitchell JS,Tucker CG,Pauken KE,Papas K,Appakalai B,Spanier JA,Fife BT
47-4801 was used in Flow cytometry/Cell sorting to suggest that insulin-producing Β cells respond to pancreatic inflammation and IFN-γ production by upregulating PD-L1 expression to limit self-reactive T cells.
Tue May 29 00:00:00 EDT 2018
BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.
Oncotarget
Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P
47-4801 was used in Flow cytometry/Cell sorting to evaluate the role played by BNIP3 in modulating the interface between B16-F10 melanoma cells and immune cells.
Tue Apr 03 00:00:00 EDT 2018
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
JCI insight
Lee-Sherick AB,Jacobsen KM,Henry CJ,Huey MG,Parker RE,Page LS,Hill AA,Wang X,Frye SV,Earp HS,Jordan CT,DeRyckere D,Graham DK
47-4801 was used in Flow cytometry/Cell sorting to demonstrate both the direct therapeutic effects of MERTK inhibition on leukaemia cells and the induction of anti-leukaemia immunity via suppression of the coinhibitory PD-1 axis.
Fri Nov 02 00:00:00 EDT 2018
CCR7 defines a precursor for murine iNKT cells in thymus and periphery.
eLife
Wang H,Hogquist KA
47-4801 was used in Flow cytometry/Cell sorting to demonstrate that the thymus is both a source of iNKT progenitors and a site of tissue dependent effector cell differentiation.
Mon Aug 13 00:00:00 EDT 2018
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Nature medicine
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Graspeuntner S,Cappelletti M,Wu D,Mukherjee R,Chan CC,Lawson MJ,Klarquist J,Sünderhauf A,Softic S,Kahn CR,Stemmer K,Iwakura Y,Aronow BJ,Karns R,Steinbrecher KA,Karp CL,Sheridan R,Shanmukhappa SK,Reynaud D,Haslam DB,Sina C,Rupp J,Hogan SP,Divanovic S
47-4801 was used in Flow cytometry/Cell sorting to show thermoneutral housing provides a sex-independent model of exacerbated NAFLD in mice and represents a novel approach for interrogation of the cellular and molecular mechanisms underlying disease pathogenesis.
Sat Jul 01 00:00:00 EDT 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
47-4801 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model.
The Prostate
Colinot DL,Garbuz T,Bosland MC,Wang L,Rice SE,Sullivan WJ,Arrizabalaga G,Jerde TJ
47-4801-82 was used in Flow cytometry/Cell sorting to report that T. gondii chronically encysts and induces chronic inflammation within the prostate of any species.
Sat Jul 01 00:00:00 EDT 2017
Upregulation of heme oxygenase-1 in Kupffer cells blocks mast cell degranulation and inhibits dendritic cell migration in vitro.
Molecular medicine reports
Ma YY,Yang MQ,He ZG,Fan MH,Huang M,Teng F,Wei Q,Li JY
47-4801 was used in Flow cytometry/Cell sorting to investigate upregulation of heme oxygenase-1 (HO-1) in KCs upon interaction with mast cells (MCs), and the effects on dendritic cell (DC) function.
Thu Jun 01 00:00:00 EDT 2017
Cytokine and hormonal regulation of bone marrow immune cell Wnt10b expression.
PloS one
Collins FL,Rios-Arce ND,McCabe LR,Parameswaran N
47-4801 was used in Flow cytometry/Cell sorting to determine the potential regulation of Wnt10b by estrogen and TNFα, showing regulation of expression by cytokines and hormones.
Mon Oct 09 00:00:00 EDT 2017
CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.
The Journal of biological chemistry
Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC
47-4801 was used in Flow cytometry/Cell sorting to study the function of CD36 in malaria immunity.
Fri Jun 02 00:00:00 EDT 2017
Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature.
PloS one
Muley A,Odaka Y,Lewkowich IP,Vemaraju S,Yamaguchi TP,Shawber C,Dickie BH,Lang RA
47-4801 was used in Flow cytometry/Cell sorting to establish that Wnt ligands from macrophages play an important role in development of the lymphatic capillary vessels.
Thu Oct 19 00:00:00 EDT 2017
RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis.
Journal of hepatology
Filliol A,Piquet-Pellorce C,Raguénès-Nicol C,Dion S,Farooq M,Lucas-Clerc C,Vandenabeele P,Bertrand MJM,Le Seyec J,Samson M
47-4801-82 was used in Immunohistochemistry (Frozen) to show that in the presence of LPS liver induced hepatic injury was due to secretion of TNF by liver macrophages, and that RIPK1 acts as a powerful protector of hepatocyte death.
Thu Jun 01 00:00:00 EDT 2017
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kirschbaum K,Sonner JK,Zeller MW,Deumelandt K,Bode J,Sharma R,Krüwel T,Fischer M,Hoffmann A,Costa da Silva M,Muckenthaler MU,Wick W,Tews B,Chen JW,Heiland S,Bendszus M,Platten M,Breckwoldt MO
47480182 was used in flow cytometry to use MRI to track iron oxide nanoparticles in vivo
Tue Nov 15 00:00:00 EST 2016
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
PloS one
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Cappelletti M,Huppert SS,Iwakura Y,Dong C,Shanmukhappa SK,Divanovic S
47-4801 was used in Flow cytometry/Cell sorting to indicate that the IL-17 axis also plays a role in a MCDD-induced model of NAFLD pathogenesis.
Tue Jul 19 00:00:00 EDT 2016
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols
von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC
47-4801-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.
Sat Oct 01 00:00:00 EDT 2016
Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges.
Bioengineering & translational medicine
Margul DJ,Park J,Boehler RM,Smith DR,Johnson MA,McCreedy DA,He T,Ataliwala A,Kukushliev TV,Liang J,Sohrabi A,Goodman AG,Walthers CM,Shea LD,Seidlits SK
47-4801 was used in Flow cytometry/Cell sorting to study the role of anti-inflammatory factors in modulating the inflammatory response following spinal cord injury.
Wed Jun 01 00:00:00 EDT 2016
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.
Aging
Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV
47-4801 was used in Flow cytometry/Cell sorting to investigate the role of p16(Ink4a)/β-gal(pH6)-positive macrophages in aging, which previously was attributed solely to senescent cells.
Fri Jul 01 00:00:00 EDT 2016
Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.
Journal of immunology (Baltimore, Md. : 1950)
Eddens T,Elsegeiny W,Nelson MP,Horne W,Campfield BT,Steele C,Kolls JK
47-4801 was used in Flow cytometry/Cell sorting to examine how CD4(+) T cells contribute to host defence against Pneumocystis.
Wed Jul 01 00:00:00 EDT 2015
Interferon-γ from Brain Leukocytes Enhances Meningitis by Type 4 Streptococcus pneumoniae.
Frontiers in microbiology
Pettini E,Fiorino F,Cuppone AM,Iannelli F,Medaglini D,Pozzi G
47-4801 was used in Flow cytometry/Cell sorting to elucidate the role of IFN-γ in the neuroinflammatory response following type 4 Streptococcus pneumoniae-induced meningitis in mice.
Wed Dec 09 00:00:00 EST 2015
MIF deficiency does not alter glucose homeostasis or adipose tissue inflammatory cell infiltrates during diet-induced obesity.
Obesity (Silver Spring, Md.)
Conine SJ,Cross JV
47-4801 was used in Flow cytometry/Cell sorting to determine the effects of Circulating Macrophage Migration Inhibitory Factor deficiency in a model of high fat diet-induced obesity.
Sat Feb 01 00:00:00 EST 2014
Purinergic signaling on leukocytes infiltrating the LPS-injured lung.
PloS one
Friebe D,Yang T,Schmidt T,Borg N,Steckel B,Ding Z,Schrader J
47-4801 was used in Flow cytometry/Cell sorting to investigate the role of extracellular nucleotides/nucleosides in acute lung injury, showing purinergic signaling on leukocytes infiltrating the injured lung.
Thu Jan 15 00:00:00 EST 2015
Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia.
Biochimica et biophysica acta
Winslow V,Vaivoda R,Vasilyev A,Dombkowski D,Douaidy K,Stark C,Drake J,Guilliams E,Choudhary D,Preffer F,Stoilov I,Christmas P
47-4801 was used in Flow cytometry/Cell sorting to conclude that CYP4F18 is necessary for omega oxidation of leukotriene B4 in neutrophils, and is not compensated by other CYP enzymes.
Sun Jun 01 00:00:00 EDT 2014
mRNA-based vaccines synergize with radiation therapy to eradicate established tumors.
Radiation oncology (London, England)
Fotin-Mleczek M,Zanzinger K,Heidenreich R,Lorenz C,Kowalczyk A,Kallen KJ,Huber SM
47-4801 was used in Flow cytometry/Cell sorting to investigate how mRNA-based vaccines interact with radiation therapy in treating established tumours.
Fri Aug 15 00:00:00 EDT 2014
Ecto-5'-nucleotidase on immune cells protects from adverse cardiac remodeling.
Circulation research
Bönner F,Borg N,Jacoby C,Temme S,Ding Z,Flögel U,Schrader J
47-4801 was used in Flow cytometry/Cell sorting to examine the role of CD73 in cardiac repair and remodelling in mice after reperfused myocardial infarction.
Fri Jul 19 00:00:00 EDT 2013
Promyelocytic leukemia protein modulates establishment and maintenance of latent gammaherpesvirus infection in peritoneal cells.
Journal of virology
Sewatanon J,Liu H,Ling PD
47-4801 was used in Flow cytometry/Cell sorting to suggest that the PML protein can repress the establishment or maintenance of gammaherpesvirus latency in vivo.
Fri Nov 01 00:00:00 EDT 2013
Proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
American journal of physiology. Renal physiology
Li S,Mariappan N,Megyesi J,Shank B,Kannan K,Theus S,Price PM,Duffield JS,Portilla D
47-4801 was used in Flow cytometry/Cell sorting to study how proximal tubule PPARα attenuates renal fibrosis and inflammation caused by unilateral ureteral obstruction.
Sun Sep 01 00:00:00 EDT 2013
Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.
PloS one
Bönner F,Borg N,Burghoff S,Schrader J
47-4801 was used in Flow cytometry/Cell sorting to explore the abundance of CD73 and CD39 on immune cells under control conditions and in response to inflammation.
Thu Aug 30 00:00:00 EDT 2012
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
47-4801 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Nature communications
Frateschi S,Camerer E,Crisante G,Rieser S,Membrez M,Charles RP,Beermann F,Stehle JC,Breiden B,Sandhoff K,Rotman S,Haftek M,Wilson A,Ryser S,Steinhoff M,Coughlin SR,Hummler E
47-4801 was used in Flow cytometry/Cell sorting to study PAR2 as a downstream effector of CAP1/Prss8 in a signalling cascade, potentially providing therapeutic targets for ichthyoses, pruritus and inflammatory skin diseases.
Tue Jan 18 00:00:00 EST 2011
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology
Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ
Sat Oct 01 00:00:00 EDT 2005
