Product References
Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.
Journal of experimental & clinical cancer research : CR
Zheng Y,Wang N,Wang S,Zhang J,Yang B,Wang Z
17-4801-82 was used in Flow cytometry/Cell sorting to investigate the impact of chronic psychological stress on breast cancer growth, metastasis, and pre-metastatic niche (PMN) formation.
Sat May 20 00:00:00 EDT 2023
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Nature
Wang D,Townsend LK,DesOrmeaux GJ,Frangos SM,Batchuluun B,Dumont L,Kuhre RE,Ahmadi E,Hu S,Rebalka IA,Gautam J,Jabile MJT,Pileggi CA,Rehal S,Desjardins EM,Tsakiridis EE,Lally JSV,Juracic ES,Tupling AR,Gerstein HC,Paré G,Tsakiridis T,Harper ME,Hawke TJ,Speakman JR,Blondin DP,Holloway GP,Jørgensen SB,Steinberg GR
17-4801-82 was used in Flow cytometry/Cell sorting to indicate that therapeutic targeting of the GDF15-GFRAL pathway may be useful for maintaining energy expenditure in skeletal muscle during caloric restriction.
Sat Jul 01 00:00:00 EDT 2023
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
British journal of pharmacology
Wang Y,Gao J,Yu Y,Zhou L,Wang M,Xue W,Liu B,Wu X,Wu X,Gao H,Shen Y,Xu Q
17-4801-82 was used in flow cytometry to reveal that CA-e is a novel GR modulator with strong potency to attenuate the side effects of GC therapy and can be used as a potential molecular tool for deciphering GR signalling.
Sun Jan 01 00:00:00 EST 2023
Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis.
Cellular & molecular biology letters
Ju C,Ma Y,Zuo X,Wang X,Song Z,Zhang Z,Zhu Z,Li X,Liang Z,Ding T,Hu X,Wang Z
17-4801-82 was used in Flow cytometry/Cell sorting to clarify that the lncRNA TUG1/miR-1192/TLR3 axis is an important pathway for PBM to inhibit M1 macrophage polarization and inflammation, which provides theoretical support for its clinical application in patients with SCI.
Thu Jan 19 00:00:00 EST 2023
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.
Cancer nanotechnology
Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y
17-4801-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.
Tue Apr 25 00:00:00 EDT 2023
Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth.
Journal of nanobiotechnology
Choi H,Yeo M,Kang Y,Kim HJ,Park SG,Jang E,Park SH,Kim E,Kang S
17-4801-82 was used in Flow cytometry/Cell sorting to show that the modular functionalization of protein nanoparticles with multiple metabolic enzymes may offer the opportunity to develop new enzyme complex-based therapeutic tools that can modulate the TME by controlling cancer metabolism.
Tue Jan 03 00:00:00 EST 2023
G9a promotes inflammation in Streptococcus pneumoniae induced pneumonia mice by stimulating M1 macrophage polarization and H3K9me2 methylation in FOXP1 promoter region.
Annals of translational medicine
Li Y,Li G,Zhang L,Li Y,Zhao Z
17-4801-82 was used in Flow cytometry/Cell sorting to conclude that G9a promotes M1 polarization of macrophages by promoting H3K9me2 methylation in the FOXP1 promoter region, promoting an inflammatory response in Spn mice.
Sun May 01 00:00:00 EDT 2022
Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes.
International journal of nanomedicine
Scalzo S,Santos AK,Ferreira HAS,Costa PA,Prazeres PHDM,da Silva NJA,Guimarães LC,E Silva MM,Rodrigues Alves MTR,Viana CTR,Jesus ICG,Rodrigues AP,Birbrair A,Lobo AO,Frezard F,Mitchell MJ,Guatimosim S,Guimaraes PPG
17-4801-82 was used in Flow cytometry/Cell sorting to highlight the potential of LNPs as an efficient delivery vector for pDNA to cardiomyocytes.
Fri Jul 08 00:00:00 EDT 2022
Systemic delivery of a targeted synthetic immunostimulant transforms the immune landscape for effective tumor regression.
Cell chemical biology
Miller CL,Sagiv-Barfi I,Neuhöfer P,Czerwinski DK,Artandi SE,Bertozzi CR,Levy R,Cochran JR
17-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that conjugation to a synthetic tumor-targeted peptide can improve the efficacy of systemically administered immunostimulants and lead to durable anti-tumor immune responses.
Thu Mar 17 00:00:00 EDT 2022
Smad3 Promotes Cancer-Associated Fibroblasts Generation via Macrophage-Myofibroblast Transition.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Tang PC,Chung JY,Xue VW,Xiao J,Meng XM,Huang XR,Zhou S,Chan AS,Tsang AC,Cheng AS,Lee TL,Leung KT,Lam EW,To KF,Tang PM,Lan HY
17-4801-82 was used in Immunocytochemistry-immunoflourescence to conclude that MMT may represent a novel therapeutic target of CAF for cancer immunotherapy.
Sat Jan 01 00:00:00 EST 2022
Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model.
EBioMedicine
Ma JH,Lee E,Yoon SH,Min H,Oh JH,Hwang I,Sung Y,Ryu JH,Bok J,Yu JW
17-4801-82 was used in Flow cytometry/Cell sorting to investigate whether Cryopyrin-associated periodic syndrome-associated mutation in NLRP3 is associated with the progression of hearing loss.
Mon Aug 01 00:00:00 EDT 2022
Photobiomodulation Attenuates Neurotoxic Polarization of Macrophages by Inhibiting the Notch1-HIF-1α/NF-κB Signalling Pathway in Mice With Spinal Cord Injury.
Frontiers in immunology
Ma Y,Li P,Ju C,Zuo X,Li X,Ding T,Liang Z,Zhang J,Li K,Wang X,Zhu Z,Zhang Z,Song Z,Quan H,Hu X,Wang Z
17-4801-82 was used in Flow cytometry/Cell sorting to investigate spinal chord injury treatment with photobiomodulation of macrophages.
Fri Apr 08 00:00:00 EDT 2022
The Time Course of Monocytes Infiltration After Acoustic Overstimulation.
Frontiers in cellular neuroscience
Shin SH,Jung J,Park HR,Sim NS,Choi JY,Bae SH
17-4801-82 was used in Flow cytometry/Cell sorting to investigate time-dependent immune cell infiltration, macrophage transformation, and neutrophil involvement following acoustic stimulation.
Sat Jul 16 00:00:00 EDT 2022
Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.
Frontiers in endocrinology
Yang Y,Liu H,Zhao Y,Geng C,Chao L,Hao A
17-4801-82 was used in Flow cytometry/Cell sorting to reveal that Grim-19 deficiency influences macrophage function, characterized by enhanced proinflammatory cytokines and phagocytic activity, and this might be regulated by autophagy.
Tue Nov 22 00:00:00 EST 2022
Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity.
International journal of molecular sciences
Ortiz-Bonilla CJ,Uccello TP,Gerber SA,Lord EM,Messing EM,Lee YF
17-4801-82 was used in Flow cytometry/Cell sorting to support the potential application of TEVs in personalized medicine, and open new avenues for the development of adjuvant therapies based on patient-derived EVs aimed at preventing disease progression.
Tue Mar 08 00:00:00 EST 2022
CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
Cells
Pannunzio B,Amo-Aparicio J,Julián C,López-Vales R,Peluffo H,Lago N
17-4801-82 was used in Flow cytometry/Cell sorting to show that CD200R1 has a role in mounting a successful acute inflammatory reaction after injury, and contributes to an effective functional recovery.
Mon May 30 00:00:00 EDT 2022
HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation.
Autophagy
Liu J,Wu X,Wang H,Wei J,Wu Q,Wang X,Yan Y,Cui J,Min J,Wang F,Zhou J
17-4801 was used in Flow cytometry/Cell sorting to identify 5 iron metabolism-associated genes specifically affected during RNA virus infection by a high-throughput assay and further found that HFE was a key negative regulator of RIG-I-like receptors (RLR)-mediated type I interferons (IFNs) signaling.
Sun Aug 01 00:00:00 EDT 2021
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.
Basic research in cardiology
Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S
17-4801 was used in Flow cytometry/Cell sorting to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise.
Fri Apr 30 00:00:00 EDT 2021
Interleukin 6 regulates the expression of programmed cell death ligand 1 in thyroid cancer.
Cancer science
Zhang GQ,Jiao Q,Shen CT,Song HJ,Zhang HZ,Qiu ZL,Luo QY
17-4801 was used in Flow cytometry/Cell sorting to investigate the expression of IL-6 and PD-L1 in thyroid cancer, and whether IL-6 regulates the PD-L1 expression.
Mon Mar 01 00:00:00 EST 2021
CD36 deficiency ameliorates drug-induced acute liver injury in mice.
Molecular medicine (Cambridge, Mass.)
Zhang C,Shi X,Su Z,Hu C,Mu X,Pan J,Li M,Teng F,Ling T,Zhao T,Xu C,Ji G,You Q
17-4801-82 was used in Flow Cytometry to demonstrate that CD36 deficiency ameliorated APAP-induced acute liver injury and inflammatory responses by decreasing JNK activation.
Sun Jun 06 00:00:00 EDT 2021
Transient activation of tumoral DNA damage tolerance pathway coupled with immune checkpoint blockade exerts durable tumor regression in mouse melanoma.
Pigment cell & melanoma research
Zhuo M,Gorgun FM,Tyler DS,Englander EW
17-4801-82 was used in Flow cytometry/Cell sorting to expect that this new combination protocol affords insights with clinical relevance that will help expand the range of patients who benefit from ICB therapy.
Sat May 01 00:00:00 EDT 2021
MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway.
Frontiers in pharmacology
Zhu X,Guo Q,Zou J,Wang B,Zhang Z,Wei R,Zhao L,Zhang Y,Chu C,Fu X,Li X
17-4801 was used in Flow cytometry/Cell sorting to confirm that miR-19a-3p, as a direct regulator of STAT1, inhibited M1 macrophages polarization.
Sun May 23 00:00:00 EDT 2021
Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration.
Cell death discovery
Tao Y,Wang F,Xu Z,Lu X,Yang Y,Wu J,Yao C,Yi F,Li J,Huang Z,Liu Y
17-4801-82 was used in Immunohistochemistry (Paraffin) to study the involvement of foamy cells in peripheral nerve regeneration in a GSDMD-/- mouse model.
Mon Jun 14 00:00:00 EDT 2021
Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration.
Cell death discovery
Tao Y,Wang F,Xu Z,Lu X,Yang Y,Wu J,Yao C,Yi F,Li J,Huang Z,Liu Y
17-4801-82 was used in Immunohistochemistry (Paraffin) to study the involvement of foamy cells in peripheral nerve regeneration in a GSDMD-/- mouse model.
Mon Jun 14 00:00:00 EDT 2021
CD5L deficiency attenuate acetaminophen-induced liver damage in mice via regulation of JNK and ERK signaling pathway.
Cell death discovery
Li M,Ling T,Teng F,Hu C,Su Z,Zhang C,Li X,Zhao T,Mu X,Li Y,Pan J,You Q
17-4801-82 was used in Flow Cytometry to reveal that CD5L may be a potential therapeutic target for prevention and treatment of APAP-induced liver injury.
Mon Nov 08 00:00:00 EST 2021
Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis.
Nutrients
Knopp T,Bieler T,Jung R,Ringen J,Molitor M,Jurda A,Münzel T,Waisman A,Wenzel P,Karbach SH,Wild J
17-4801-82 was used in Flow Cytometry to study the influence of dietary protein on psoriasis-like skin disease in mice.
Mon May 31 00:00:00 EDT 2021
Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis.
Parasite immunology
Jebbawi F,Bellanger AP,Lunström-Stadelmann B,Rufener R,Dosch M,Goepfert C,Gottstein B,Millon L,Grandgirard D,Leib SL,Beldi G,Wang J
17-4801-82 was used in Flow cytometry/Cell sorting to suggest that the PD-L1 pathway plays an important role by regulating adaptive and innate immune cells against E. multilocularis infection, with significant modulation of tissue inflammation.
Sun Aug 01 00:00:00 EDT 2021
BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions.
Cell death & disease
Zhang D,Huang J,Wang F,Ding H,Cui Y,Yang Y,Xu J,Luo H,Gao Y,Pan L,Wu Y,Gong Y,Xie L,Liu Z,Qu Y,Zhang L,Liu W,Zhang W,Zhao S,Yi Q,Niu T,Zheng Y
17-4801-82 was used in Flow Cytometry to demonstrate the role of the polycomb-group protein, BMI1, in the modulation of pro-myeloma macrophages.
Sat May 15 00:00:00 EDT 2021
Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.
Physiological reports
Miura I,Komine S,Okada K,Wada S,Warabi E,Uchida F,Oh S,Suzuki H,Mizokami Y,Shoda J
17-4801-82 was used in Flow cytometry/Cell sorting to suggest a molecular mechanism for the beneficial effect of exercise in the management of patients with nonalcoholic fatty liver disease.
Sat May 01 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
17-4801 was used in Flow cytometry/Cell sorting to provide demonstration of DA-DRD5 signaling in colonic macrophages controlling the development of colitis by regulating M1/M2 macrophage polarization.
Mon May 17 00:00:00 EDT 2021
Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins.
Cell chemical biology
Park DD,Chen J,Kudelka MR,Jia N,Haller CA,Kosaraju R,Premji AM,Galizzi M,Nairn AV,Moremen KW,Cummings RD,Chaikof EL
17-4801-82 was used in Flow Cytometry to study the features of glycosylation that are associated with macrophage lineage and polarization in mice.
Thu Apr 15 00:00:00 EDT 2021
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways.
Cell death discovery
Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ
17-4801-82 was used in Flow Cytometry to provide insights into the functional role of bone marrow-derived sesenchymal stem cell in alleviating liver fibrosis.
Mon Sep 13 00:00:00 EDT 2021
Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease.
Med (New York, N.Y.)
Matei DE,Menon M,Alber DG,Smith AM,Nedjat-Shokouhi B,Fasano A,Magill L,Duhlin A,Bitoun S,Gleizes A,Hacein-Bey-Abina S,Manson JJ,Rosser EC,Klein N,Blair PA,Mauri C
17-4801-82 was used in Flow Cytometry to analyze changes in markers of gut permeability, damage, and inflammation in peripheral blood and serum of rheumatoid arthritis patients, as well as relevant organs in engineered arthritic mice.
Fri Jul 09 00:00:00 EDT 2021
Chronic exposure to IL-6 induces a desensitized phenotype of the microglia.
Journal of neuroinflammation
Recasens M,Almolda B,Pérez-Clausell J,Campbell IL,González B,Castellano B
17-4801-82 was used in Flow Cytometry to evaluate the effects of chronic IL-6 production on the immune response associated with CNS-axonal anterograde degeneration.
Fri Jan 22 00:00:00 EST 2021
Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sadhu S,Decker C,Sansbury BE,Marinello M,Seyfried A,Howard J,Mori M,Hosseini Z,Arunachalam T,Finn AV,Lamar JM,Jourd'heuil D,Guo L,MacNamara KC,Spite M,Fredman G
17-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that sublethal radiation drives macrophage senescence and efferocytosis defects and suggest that RvD1 may be a new therapeutic strategy to limit radiation-induced tissue damage.
Fri Oct 01 00:00:00 EDT 2021
Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction.
Journal of leukocyte biology
Zhang J,Wu Q,Yin C,Jia X,Zhao Z,Zhang X,Yuan G,Hu H,Zhao Q
17-4801-82 was used in Flow cytometry/Cell sorting to underscore the critical role of macrophages in bone regeneration and clarify the molecular mechanisms of Ca2+ -mediated osteoinduction by biomaterials, which is of great significance for the future design of biomaterial-oriented tissue regeneration engineering.
Wed Sep 01 00:00:00 EDT 2021
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Immunity
Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.
Tue Aug 18 00:00:00 EDT 2020
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.
Cancer cell
Marjanovic ND,Hofree M,Chan JE,Canner D,Wu K,Trakala M,Hartmann GG,Smith OC,Kim JY,Evans KV,Hudson A,Ashenberg O,Porter CBM,Bejnood A,Subramanian A,Pitter K,Yan Y,Delorey T,Phillips DR,Shah N,Chaudhary O,Tsankov A,Hollmann T,Rekhtman N,Massion PP,Poirier JT,Mazutis L,Li R,Lee JH,Amon A,Rudin CM,Jacks T,Regev A,Tammela T
17-4801-82 was used in Flow Cytometry to profile cellular transcriptomes of lung tumours at different stages.
Mon Aug 10 00:00:00 EDT 2020
Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.
Nano-micro letters
Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y
17-4801-82 was used in Flow Cytometry to demonstrate that biomaterials developed to have specific regulatory capacities for immune cells can be used to control the early inflammatory responses of implanted materials and induce osteogenesis.
Sat Nov 21 00:00:00 EST 2020
Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.
Developmental cell
Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM
17-4801 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.
Mon Apr 20 00:00:00 EDT 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
17-4801-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder.
Mucosal immunology
Bottek J,Soun C,Lill JK,Dixit A,Thiebes S,Beerlage AL,Horstmann M,Urbanek A,Heuer H,Uszkoreit J,Eisenacher M,Bracht T,Sitek B,Hoffmann F,Vijitha N,von Eggeling F,Engel DR
17-4801-82 was used in Immunohistochemistry (PFA fixed) to describe the crosstalk between the infected urothelium and macrophages through IL-6-induced CX3CL1 expression.
Wed Jul 01 00:00:00 EDT 2020
M2 polarization of tumor-associated macrophages is dependent on integrin β3 via peroxisome proliferator-activated receptor-γ up-regulation in breast cancer.
Immunology
Shu Y,Qin M,Song Y,Tang Q,Huang Y,Shen P,Lu Y
17-4801-82 was used in Flow Cytometry to find a connection between integrin β3 and macrophage polarization.
Sat Aug 01 00:00:00 EDT 2020
Deficiency in ZMPSTE24 and resulting farnesyl-prelamin A accumulation only modestly affect mouse adipose tissue stores.
Journal of lipid research
Heizer PJ,Yang Y,Tu Y,Kim PH,Chen NY,Hu Y,Yoshinaga Y,de Jong PJ,Vergnes L,Morales JE,Li RL,Jackson N,Reue K,Young SG,Fong LG
17-4801 was used in Flow cytometry/Cell sorting to generate a conditional knockout Zmpste24 allele and use it to create adipocyte-specific Zmpste24-knockout mice.
Sun Mar 01 00:00:00 EST 2020
Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages.
International journal of molecular medicine
Chen JJ,He YS,Zhong XJ,Cai ZL,Lyu YS,Zhao ZF,Ji K
17-4801 was used in Flow cytometry/Cell sorting to reveal that high rAf RNASET2 activity is required for rAf RNASET2‚induced M2 polarization of macrophages.
Sat Aug 01 00:00:00 EDT 2020
Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.
Journal of cellular and molecular medicine
Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y
17-4801 was used in Flow cytometry/Cell sorting to provide evidence reporting that MSC-secreted EVs carry TGF-β1 to promote M2 polarization of macrophages via modulation of the miR-132/Mycbp2/TSC2 axis.
Sun Nov 01 00:00:00 EDT 2020
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages.
Molecules and cells
Park SM,Do-Thi VA,Lee JO,Lee H,Kim YS
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that IL-9 can induce an anti-metastasis effect by enhancing the polarization and proliferation of M1 macrophages.
Sun May 31 00:00:00 EDT 2020
Immunotherapy of Bacillus Calmette‑Guérin by targeting macrophages against bladder cancer in a NOD/scid IL2Rg‑/‑ mouse model.
Molecular medicine reports
Tan QL,Zhou CY,Cheng L,Luo M,Liu CP,Xu WX,Zhang X,Zeng X
17-4801 was used in Flow cytometry/Cell sorting to investigate the role and potential mechanism of Bacillus Calmette-Guérin (BCG) immunotherapy for bladder cancer (BCa).
Wed Jul 01 00:00:00 EDT 2020
A mouse model of humanized liver shows a human-like lipid profile, but does not form atherosclerotic plaque after western type diet.
Biochemical and biophysical research communications
Sari G,Meester EJ,van der Zee LC,Wouters K,van Lennep JR,Peppelenbosch M,Boonstra A,Van der Heiden K,Mulder MMT,Vanwolleghem T
17-4801 was used in Flow cytometry/Cell sorting to examine the suitability of mice with a humanized liver as a model for lipoprotein studies and studies on plaque formation, given the central role of hepatocytes in lipoprotein synthesis and metabolism.
Thu Apr 02 00:00:00 EDT 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
17-4801 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.
Journal of the American Heart Association
Du LJ,Sun JY,Zhang WC,Wang YL,Zhu H,Liu T,Gao MZ,Zheng C,Zhang YY,Liu Y,Liu Y,Shao S,Zhang XQ,Leng Q,Auwerx J,Duan SZ
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NCOR1 is a critical regulator of macrophage inflammation and proliferation and that deficiency of NCOR1 in macrophages attenuates MI and neointimal hyperplasia.
Tue Aug 04 00:00:00 EDT 2020
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
17-4801 was used in Flow cytometry/Cell sorting to prove decreased miR-103 is involved in RSA by increasing M1 macrophage polarization via promoting STAT1/IRF1 signaling pathway. miR-103 may be explored as a promising diagnostic marker and therapeutic target for RSA.
Fri Nov 12 00:00:00 EST 2021
4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation.
BMC complementary medicine and therapies
Zhou C,Chen R,Gao F,Zhang J,Lu F
17-4801 was used in Flow cytometry/Cell sorting to investigate the effects and mechanisms of 4-HIL on obesity-induced inflammation in RAW264.7 macrophages and 3 T3-L1 adipocytes co-culture system.
Wed Dec 09 00:00:00 EST 2020
Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow.
Cell reports
Paubelle E,Zylbersztejn F,Maciel TT,Carvalho C,Mupo A,Cheok M,Lieben L,Sujobert P,Decroocq J,Yokoyama A,Asnafi V,Macintyre E,Tamburini J,Bardet V,Castaigne S,Preudhomme C,Dombret H,Carmeliet G,Bouscary D,Ginzburg YZ,de Thé H,Benhamou M,Monteiro RC,Vassiliou GS,Hermine O,Moura IC
17-4801 was used in Flow cytometry/Cell sorting to present an unexpected role of VDR in normal hematopoiesis and in leukemogenesis.
Tue Jan 21 00:00:00 EST 2020
PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis.
Theranostics
Jin K,Liu Y,Shi Y,Zhang H,Sun Y,Zhangyuan G,Wang F,Yu W,Wang J,Tao X,Chen X,Zhang W,Sun B
17-4801 was used in Flow cytometry/Cell sorting to indicate that PTPROt plays a dual role in inflammation via the NF-κB signaling pathway in liver macrophages during NASH.
Mon Jul 26 00:00:00 EDT 2021
Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation.
Science advances
Ma C,Yang D,Wang B,Wu C,Wu Y,Li S,Liu X,Lassen K,Dai L,Yang S
17-4801 was used in Flow cytometry/Cell sorting to provide the first demonstration of GSDMD's role in controlling colitis and a detailed delineation of the underlying mechanism.
Fri May 01 00:00:00 EDT 2020
Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome.
Frontiers in immunology
Hou L,Yang L,Chang N,Zhao X,Zhou X,Dong C,Liu F,Yang L,Li L
17-4801 was used in Flow cytometry/Cell sorting to show that targeting macrophage S1PR2 retarded liver inflammation and fibrogenesis via downregulating NLRP3 inflammasome.
Thu Apr 01 00:00:00 EDT 2021
MicroRNAs of the miR-17~9 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression.
eLife
Zhang X,Liu J,Wu L,Hu X
17-4801 was used in Flow cytometry/Cell sorting to identifiy miR-17~92 family miRNAs as crucial regulators of the balance between pro- and anti-inflammatory cytokines and exemplify how macrophage-intrinsic regulatory circuit exerted impactful influence on general physiology.
Thu Nov 05 00:00:00 EST 2020
Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.
Cell reports
Tur J,Pereira-Lopes S,Vico T,Marín EA,Muñoz JP,Hernández-Alvarez M,Cardona PJ,Zorzano A,Lloberas J,Celada A
17-4801 was used in Flow cytometry/Cell sorting to reveal an unexpected contribution of Mfn2 to ROS production and inflammation in macrophages.
Tue Aug 25 00:00:00 EDT 2020
Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.
JCI insight
Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M
17-4801 was used in Flow cytometry/Cell sorting to demonstrate a pivotal role for hyaluronan in successful pregnancy by fine-tuning the periembryo avascular niche and maternal vascular morphogenesis.
Thu Nov 19 00:00:00 EST 2020
Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice.
Journal for immunotherapy of cancer
Selvanesan BC,Meena K,Beck A,Meheus L,Lara O,Rooman I,Gravekamp C
17-4801 was used in Flow cytometry/Cell sorting to highlight the potential of NAM+GEM as immunotherapy for advanced pancreatic cancer.
Sun Nov 01 00:00:00 EDT 2020
NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
EBioMedicine
Wei M,Ma Y,Shen L,Xu Y,Liu L,Bu X,Guo Z,Qin H,Li Z,Wang Z,Wu K,Yao L,Li J,Zhang J
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NDRG2 is an essential colonic epithelial barrier regulator and plays an important role in gut homeostasis maintenance and colitis-associated tumour development.
Sun Nov 01 00:00:00 EDT 2020
Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells.
Cell reports
Clark NM,Martinez LM,Murdock S,deLigio JT,Olex AL,Effi C,Dozmorov MG,Bos PD
17-4801 was used in Flow cytometry/Cell sorting to highlight the strong myeloid dependency of breast cancer and provide the basis for the development of therapeutic strategies based on manipulation of the IFN-γ signaling pathway in monocytes.
Tue Dec 08 00:00:00 EST 2020
Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.
Cells
Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J
17-4801 was used in Flow cytometry/Cell sorting to evaluate the potential of a bivalent carboxylate inhibitor to selectively inhibit the trimeric proteoform of MMP-9 and compare this with a corresponding monovalent inhibitor.
Tue Jul 07 00:00:00 EDT 2020
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.
Nature communications
Yu L,Zhang B,Deochand D,Sacta MA,Coppo M,Shang Y,Guo Z,Zeng X,Rollins DA,Tharmalingam B,Li R,Chinenov Y,Rogatsky I,Hu X
17-4801 was used in Flow cytometry/Cell sorting to study the contribution of post-initiation steps to macrophage activation.
Fri May 08 00:00:00 EDT 2020
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y
17-4801-82 was used in Flow Cytometry to unravel a promising biphotonic strategy for precision treatment of cancer.
Tue Dec 01 00:00:00 EST 2020
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Nature
Mahmoudi S,Mancini E,Xu L,Moore A,Jahanbani F,Hebestreit K,Srinivasan R,Li X,Devarajan K,Prélot L,Ang CE,Shibuya Y,Benayoun BA,Chang ALS,Wernig M,Wysocka J,Longaker MT,Snyder MP,Brunet A
17-4801 was used in Flow cytometry/Cell sorting to show that this variability may reflect distinct stochastic ageing trajectories between individuals, and could help in developing personalized strategies to improve iPS cell generation and wound healing in elderly individuals.
Tue Oct 01 00:00:00 EDT 2019
Metabolic regulation of gene expression by histone lactylation.
Nature
Zhang D,Tang Z,Huang H,Zhou G,Cui C,Weng Y,Liu W,Kim S,Lee S,Perez-Neut M,Ding J,Czyz D,Hu R,Ye Z,He M,Zheng YG,Shuman HA,Dai L,Ren B,Roeder RG,Becker L,Zhao Y
17-4801 was used in Flow cytometry/Cell sorting to show that lactate-derived lactylation of histone lysine residues serves as an epigenetic modification that directly stimulates gene transcription from chromatin.
Tue Oct 01 00:00:00 EDT 2019
A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages.
Immunity
Buechler MB,Kim KW,Onufer EJ,Williams JW,Little CC,Dominguez CX,Li Q,Sandoval W,Cooper JE,Harris CA,Junttila MR,Randolph GJ,Turley SJ
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the GATA6 transcriptional program is a common feature of macrophages residing in all visceral body cavities.
Tue Jul 16 00:00:00 EDT 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
17-4801-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
17-4801-82 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.
Mon Nov 04 00:00:00 EST 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
17-4801 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 EDT 2019
IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Heinen A,Nederlof R,Panjwani P,Spychala A,Tschaidse T,Reffelt H,Boy J,Raupach A,Gödecke S,Petzsch P,Köhrer K,Grandoch M,Petz A,Fischer JW,Alter C,Vasilevska J,Lang P,Gödecke A
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that short-term insulin-like growth factor 1 treatment for 3 days after acute myocardial infarction improved cardiac function after 1 and 4 weeks.
Wed Jan 02 00:00:00 EST 2019
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.
Cancer immunology research
Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR
17-4801 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.
Mon Apr 01 00:00:00 EDT 2019
Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.
Journal of cellular and molecular medicine
Gu AQ,Li DD,Wei DP,Liu YQ,Ji WH,Yang Y,Lin HY,Peng JP
17-4801 was used in Flow cytometry/Cell sorting to study the relationship between cytochrome P450 26A1 and immune cells during the peri-implantation period in mice.
Thu Aug 01 00:00:00 EDT 2019
The Contribution of the Omentum to the Outcome From Sepsis: An Experimental Animal Study.
Shock (Augusta, Ga.)
Wang AW,Cauvi DM,Hawisher D,Reyes T,Coimbra R,Bickler S,De Maio A
17-4801-82 was used in Flow Cytometry to understand the link between the omentum and possible sepsis.
Sun Dec 01 00:00:00 EST 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
17-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that p53 activation mediated by APG-115 promotes antitumor immunity in the tumor microenvironment (TME) regardless of the Trp53 status of tumors per se.
Thu Nov 28 00:00:00 EST 2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology
Liu C,Whitener RL,Lin A,Xu Y,Chen J,Savinov A,Leiding JW,Wallet MA,Mathews CE
17-4801-82 was used in Flow Cytometry to demonstrate that Ncf1 (p47phox) is required for activation and effector function of CD8+ T cells by acting both intrinsically within the T cell as well as within professional antigen presenting cells.
Wed Sep 09 00:00:00 EDT 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
17-4801 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Nature communications
Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N
17-4801-82 was used in Flow Cytometry to find that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β.
Thu Sep 26 00:00:00 EDT 2019
Mechanical stretch induces hair regeneration through the alternative activation of macrophages.
Nature communications
Chu SY,Chou CH,Huang HD,Yen MH,Hong HC,Chao PH,Wang YH,Chen PY,Nian SX,Chen YR,Liou LY,Liu YC,Chen HM,Lin FM,Chang YT,Chen CC,Lee OK
17-4801 was used in Flow cytometry/Cell sorting to study the mechanism by which mechanical stretch induces hair regeneration.
Wed Apr 03 00:00:00 EDT 2019
The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.
Frontiers in pharmacology
Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK
17-4801 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.
Wed Sep 30 00:00:00 EDT 2020
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.
Cell death discovery
Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J
17-4801-82 was used in Flow Cytometry to identify a direct role of VP1 in EV71-induced pulmonary edema and demonstrate that NETs may be both harmful and beneficial in EV71 infection.
Wed Sep 30 00:00:00 EDT 2020
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
17-4801 was used in Flow cytometry/Cell sorting to reveal a link between mitochondrial function, lysosomal integrity and MHC class I presentation in intestinal epithelial cells.
Thu Jun 28 00:00:00 EDT 2018
Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.
Breast cancer research : BCR
Donzelli S,Milano E,Pruszko M,Sacconi A,Masciarelli S,Iosue I,Melucci E,Gallo E,Terrenato I,Mottolese M,Zylicz M,Zylicz A,Fazi F,Blandino G,Fontemaggi G
17-4801 was used in Flow cytometry/Cell sorting to investigate whether ID4 exerts its pro-angiogenic function while also modulating the activity of tumour-associated macrophages in breast cancer.
Tue Jun 19 00:00:00 EDT 2018
Adipocyte-Derived Exosomes Carrying Sonic Hedgehog Mediate M1 Macrophage Polarization-Induced Insulin Resistance via Ptch and PI3K Pathways.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Song M,Han L,Chen FF,Wang D,Wang F,Zhang L,Wang ZH,Zhong M,Tang MX,Zhang W
17-4801 was used in Flow cytometry/Cell sorting to study the impact of adipocyte-derived exosomes carrying Sonic hedgehog on the pro-inflammatory activation of macrophages and consequently, adipocyte insulin resistance.
Fri Sep 14 00:00:00 EDT 2018
GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function.
Frontiers in immunology
Sun L,Rautela J,Delconte RB,Souza-Fonseca-Guimaraes F,Carrington EM,Schenk RL,Herold MJ,Huntington ND,Lew AM,Xu Y,Zhan Y
17-4801 was used in Flow cytometry/Cell sorting to study whether the dosage of GM-CSF regulates the development of three types of myeloid cells from cultured bone marrow cells.
Fri Sep 20 00:00:00 EDT 2019
CD4+ and CD8+ T Cells Exert Regulatory Properties During Experimental Acute Aristolochic Acid Nephropathy.
Scientific reports
Baudoux T,Husson C,De Prez E,Jadot I,Antoine MH,Nortier JL,Hougardy JM
17-4801-82 was used in Flow Cytometry to investigate the role of T-cell subpopulations in the acute phase of the mouse mode for transient acute proximal tubule necrosis.
Wed Mar 28 00:00:00 EDT 2018
Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression.
Viruses
Marín MQ,Pérez P,Gómez CE,Sorzano CÓS,Esteban M,García-Arriaza J
17-4801 was used in Flow cytometry/Cell sorting to support the consideration of these vectors as potential vaccine candidates against HCV.
Wed Aug 08 00:00:00 EDT 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.
Thu Mar 22 00:00:00 EDT 2018
Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.
The Journal of biological chemistry
Castelblanco M,Lugrin J,Ehirchiou D,Nasi S,Ishii I,So A,Martinon F,Busso N
17-4801 was used in Flow cytometry/Cell sorting to study the effects of exogenous and endogenous hydorgen sulfide (H2S) on NLRP3 inflammasome activation.
Fri Feb 16 00:00:00 EST 2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications
Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA
17-4801 was used in Flow cytometry/Cell sorting to elucidate a novel role for CCR2+ haematopoietic stem cells in overcoming brain tumour resistance to PD-1 checkpoint blockade and adoptive cellular therapy in multiple invasive brain tumour models.
Wed Oct 17 00:00:00 EDT 2018
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Nature communications
Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H
17-4801 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.
Mon Sep 24 00:00:00 EDT 2018
Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency.
Frontiers in cellular neuroscience
Beckers L,Stroobants S,D'Hooge R,Baes M
17-4801 was used in Flow cytometry/Cell sorting to study the impact of microgliosis on neuropathology, behaviour and clinical decline in neuropathological conditions.
Wed Sep 30 00:00:00 EDT 2020
Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae.
Frontiers in immunology
Farhat K,Bodart G,Charlet-Renard C,Desmet CJ,Moutschen M,Beguin Y,Baron F,Melin P,Quatresooz P,Parent AS,Desmecht D,Sirard JC,Salvatori R,Martens H,Geenen VG
17-4801 was used in Flow cytometry/Cell sorting to investigate vaccinal and anti-infectious responses of Ghrh-/- mice against S. pneumoniae, a pathogen carrying T-independent antigens.
Wed Sep 25 00:00:00 EDT 2019
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
17-4801 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
17-4801-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
17-4801 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.
Cell
Ulland TK,Song WM,Huang SC,Ulrich JD,Sergushichev A,Beatty WL,Loboda AA,Zhou Y,Cairns NJ,Kambal A,Loginicheva E,Gilfillan S,Cella M,Virgin HW,Unanue ER,Wang Y,Artyomov MN,Holtzman DM,Colonna M
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that TREM2 enables microglial responses during Alzheimer's disease by sustaining cellular energetic and biosynthetic metabolism.
Thu Aug 10 00:00:00 EDT 2017
Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis.
Cancer cell
Canli Ö,Nicolas AM,Gupta J,Finkelmeier F,Goncharova O,Pesic M,Neumann T,Horst D,Löwer M,Sahin U,Greten FR
17-4801 was used in Flow cytometry/Cell sorting to identify a crosstalk between myeloid cell-derived reactive oxygen species molecules, oxidative DNA damage and tumour necrosis factor α-mediated signalling to orchestrate a tumour-promoting microenvironment causing invasive cancer.
Mon Dec 11 00:00:00 EST 2017
Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.
Cell host & microbe
Thevaranjan N,Puchta A,Schulz C,Naidoo A,Szamosi JC,Verschoor CP,Loukov D,Schenck LP,Jury J,Foley KP,Schertzer JD,Larché MJ,Davidson DJ,Verdú EF,Surette MG,Bowdish DME
17-4801 was used in Flow cytometry/Cell sorting to study the potential of changes to the microbiota as a strategy for reducing age-associated inflammation and the accompanying morbidity.
Wed Apr 12 00:00:00 EDT 2017
Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis.
The Journal of clinical investigation
Kim W,Khan SK,Gvozdenovic-Jeremic J,Kim Y,Dahlman J,Kim H,Park O,Ishitani T,Jho EH,Gao B,Yang Y
17480182 was used in flow cytometry to demonstrate that the Hippo, Wnt/beta-catenin, and Notch pathways interact to regulate liver size and inhibit hepatocellular carcinoma
Tue Jan 03 00:00:00 EST 2017
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
17-4801 was used in Flow cytometry/Cell sorting to demonstrate two distinct signalling pathways for TLR4, one via the BCR and the other through MYD88.
Mon May 01 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
17-4801 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
17-4801-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
17-4801 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy.
International journal of cancer
Santos JM,Havunen R,Siurala M,Cervera-Carrascon V,Tähtinen S,Sorsa S,Anttila M,Karell P,Kanerva A,Hemminki A
17-4801-82 was used in Flow Cytometry to study the efficacy and safety of intratumorally administered IL-2 coding adenoviruses in combination with lymphocyte therapy in Syrian hamsters bearing pancreatic tumours.
Sun Oct 01 00:00:00 EDT 2017
Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.
Oxidative medicine and cellular longevity
Ramadori P,Drescher H,Erschfeld S,Fragoulis A,Kensler TW,Wruck CJ,Cubero FJ,Trautwein C,Streetz KL,Kroy DC
17-4801 was used in Flow cytometry/Cell sorting to elucidate the effect of Nrf2 overactivation on cellular events in c-met deficient hepatocytes.
Wed Jan 31 00:00:00 EST 2018
Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.
Inflammatory bowel diseases
McLean MH,Andrews C,Hanson ML,Baseler WA,Anver MR,Senkevitch E,Staniszewska AK,Smith C,Davies LC,Hixon J,Li W,Shen W,Steidler L,Durum SK
17-4801 was used in Flow cytometry/Cell sorting to define the efficacy of interleukin (IL)-27 in acute severe colitis and characterise novel IL-27-driven mechanisms of immunosuppression in the colonic mucosa.
Wed Nov 01 00:00:00 EDT 2017
Rediscovering peritoneal macrophages in a murine endometriosis model.
Human reproduction (Oxford, England)
Yuan M,Li D,An M,Li Q,Zhang L,Wang G
17-4801 was used in Flow Cytometry to study the role of large and small peritoneal macrophages in endometriosis.
Sun Jan 01 00:00:00 EST 2017
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
17-4801 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 EDT 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that BM-derived DC culture systems were heterogeneous, comprising of non-adherent cells, adherent cells, mixed cells and firmly adherent cells.
Wed Nov 01 00:00:00 EDT 2017
The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.
Cancer prevention research (Philadelphia, Pa.)
Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL
17-4801 was used in Flow cytometry/Cell sorting to study the ability of treprostinil to chemoprevent urethane-induced murine lung adenocarcinoma.
Wed Nov 01 00:00:00 EDT 2017
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration.
BioMed research international
Müller J,von Bernstorff W,Heidecke CD,Schulze T
17-4801 was used in Flow cytometry/Cell sorting to show the expression of different specific S1P receptor profiles may provide a possibility to selectively influence M1- or M2-polarized macrophages.
Fri Apr 28 00:00:00 EDT 2017
Anti-PD-L1 peptide improves survival in sepsis.
The Journal of surgical research
Shindo Y,McDonough JS,Chang KC,Ramachandra M,Sasikumar PG,Hotchkiss RS
17-4801 was used in Flow cytometry/Cell sorting to assess the efficacy of a novel short-acting peptide that inhibits programmed cell death 1 and its ligand signalling, in a clinically relevant second-hit fungal sepsis model.
Wed Feb 01 00:00:00 EST 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.
Nature communications
Liang H,Deng L,Hou Y,Meng X,Huang X,Rao E,Zheng W,Mauceri H,Mack M,Xu M,Fu YX,Weichselbaum RR
17-4801 was used in Flow cytometry/Cell sorting to demonstrate how extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING.
Thu Nov 23 00:00:00 EST 2017
IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.
PloS one
Niikura M,Inoue SI,Mineo S,Asahi H,Kobayashi F
17-4801 was used in Flow cytometry/Cell sorting to explore the role of IFN-γ receptor 1 signalling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65.
Wed Nov 29 00:00:00 EST 2017
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy.
Nature communications
Zhu G,Lynn GM,Jacobson O,Chen K,Liu Y,Zhang H,Ma Y,Zhang F,Tian R,Ni Q,Cheng S,Wang Z,Lu N,Yung BC,Wang Z,Lang L,Fu X,Jin A,Weiss ID,Vishwasrao H,Niu G,Shroff H,Klinman DM,Seder RA,Chen X
17-4801-82 was used in Flow cytometry/Cell sorting to develop albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient vaccine delivery and potent cancer immunotherapy.
Tue Dec 05 00:00:00 EST 2017
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.
Scientific reports
Costa-Gouveia J,Pancani E,Jouny S,Machelart A,Delorme V,Salzano G,Iantomasi R,Piveteau C,Queval CJ,Song OR,Flipo M,Deprez B,Saint-André JP,Hureaux J,Majlessi L,Willand N,Baulard A,Brodin P,Gref R
17-4801 was used in Flow cytometry/Cell sorting to pave the way for a future use of pCD NPs for the pulmonary delivery of the [ETH:Booster] pair in TB chemotherapy.
Fri Jul 14 00:00:00 EDT 2017
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
17-4801 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.
Thu Aug 24 00:00:00 EDT 2017
Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6.
Science advances
Kim E,Beon J,Lee S,Park SJ,Ahn H,Kim MG,Park JE,Kim W,Yuk JM,Kang SJ,Lee SH,Jo EK,Seong RH,Kim S
17-4801 was used in Flow cytometry/Cell sorting to investigate how TRAF6 protein stability is controlled in TLR signalling, showing that Inositol polyphosphate multikinase stabilises TRAF6 and promotes TLR-induced inflammation.
Sat Apr 01 00:00:00 EDT 2017
Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.
Oncotarget
Hadjidaniel MD,Muthugounder S,Hung LT,Sheard MA,Shirinbak S,Chan RY,Nakata R,Borriello L,Malvar J,Kennedy RJ,Iwakura H,Akamizu T,Sposto R,Shimada H,DeClerck YA,Asgharzadeh S
17-4801 was used in Flow cytometry/Cell sorting to indicate a novel role of tumour-associated macrophages as inducers of MYC expression in neuroblastomas lacking independent oncogene activation.
Tue Oct 31 00:00:00 EDT 2017
Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.
Frontiers in cellular and infection microbiology
Wang C,Liu P,Luo J,Ding H,Gao Y,Sun L,Luo F,Liu X,He H
17-4801 was used in Flow cytometry/Cell sorting to show geldanamycin plays an important role in attenuating virus infection-induced acute lung injury/acute respiratory distress syndrome by reducing the host's inflammatory responses.
Mon Feb 26 00:00:00 EST 2018
Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.
Journal of hepatology
Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ
17-4801 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.
Fri Jan 01 00:00:00 EST 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
17-4801 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue.
Circulation research
Sun X,Lin J,Zhang Y,Kang S,Belkin N,Wara AK,Icli B,Hamburg NM,Li D,Feinberg MW
17-4801 was used in Flow cytometry/Cell sorting to assess whether microRNA-181b impacts the pathogenesis of insulin resistance by regulating endothelial cell function in adipose tissue during obesity.
Fri Mar 04 00:00:00 EST 2016
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β.
The Journal of clinical investigation
Rackov G,Hernández-Jiménez E,Shokri R,Carmona-Rodríguez L,Mañes S,Álvarez-Mon M,López-Collazo E,Martínez-A C,Balomenos D
17-4801 was used in Flow cytometry/Cell sorting to determine whether p21 regulates macrophage reprogramming by shifting the balance between active p65-p50 and inhibitory p50-p50 NF-κB pathways.
Mon Aug 01 00:00:00 EDT 2016
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
The EMBO journal
Hagemeyer N,Kierdorf K,Frenzel K,Xue J,Ringelhan M,Abdullah Z,Godin I,Wieghofer P,Costa Jordão MJ,Ulas T,Yorgancioglu G,Rosenbauer F,Knolle PA,Heikenwalder M,Schultze JL,Prinz M
17-4801 was used in Flow Cytometry to study the cellular and molecular mechanisms which govern the origin and developmental pathways of tissue macrophages.
Mon Aug 15 00:00:00 EDT 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
17-4801 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 EST 2016
β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.
Mucosal immunology
Schippers A,Muschaweck M,Clahsen T,Tautorat S,Grieb L,Tenbrock K,Gaßler N,Wagner N
17-4801 was used in Flow cytometry/Cell sorting to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of inflammatory bowel disease.
Tue Mar 01 00:00:00 EST 2016
Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype.
The Journal of cell biology
Capote J,Kramerova I,Martinez L,Vetrone S,Barton ER,Sweeney HL,Miceli MC,Spencer MJ
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that OPN ablation promotes muscle repair via macrophage secretion of pro-myogenic growth factors.
Mon Apr 25 00:00:00 EDT 2016
A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection.
PLoS pathogens
Maelfait J,Roose K,Vereecke L,Mc Guire C,Sze M,Schuijs MJ,Willart M,Ibañez LI,Hammad H,Lambrecht BN,Beyaert R,Saelens X,van Loo G
17-4801 was used in Flow cytometry/Cell sorting to investigate the function of A20 in club cells in antiviral immunity, showing that deficiency in A20 protects against influenza virus infection.
Fri Jan 01 00:00:00 EST 2016
CSF-1 receptor signalling is governed by pre-requisite EHD1 mediated receptor display on the macrophage cell surface.
Cellular signalling
Cypher LR,Bielecki TA,Huang L,An W,Iseka F,Tom E,Storck MD,Hoppe AD,Band V,Band H
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying macrophage receptor trafficking.
Thu Sep 01 00:00:00 EDT 2016
Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.
PLoS computational biology
Rex J,Albrecht U,Ehlting C,Thomas M,Zanger UM,Sawodny O,Häussinger D,Ederer M,Feuer R,Bode JG
17-4801 was used in Flow cytometry/Cell sorting to investigate inflammatory gene expression patterns of activated macrophages via model-based characterization.
Fri Jul 01 00:00:00 EDT 2016
Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.
Infection and immunity
Chenery AL,Antignano F,Burrows K,Scheer S,Perona-Wright G,Zaph C
17-4801 was used in Flow cytometry/Cell sorting to study crosstalk between the intestine and lung during disease, showing that low-dose intestinal Trichuris muris infection alters the lung immune microenvironment.
Mon Feb 01 00:00:00 EST 2016
Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Scientific reports
Wezel A,de Vries MR,Maassen JM,Kip P,Peters EA,Karper JC,Kuiper J,Bot I,Quax PHA
17-4801 was used in Flow cytometry/Cell sorting to determine aggravated vein graft disease caused by RP105 deficiency results from an increased local inflammatory response.
Thu Apr 07 00:00:00 EDT 2016
Cathepsin L Helps to Defend Mice from Infection with Influenza A.
PloS one
Xu X,Greenland JR,Gotts JE,Matthay MA,Caughey GH
17-4801 was used in Flow cytometry/Cell sorting to show that cathepsin L supports innate and adaptive responses, confering a survival advantage on mice infected with the orthomyxovirus influenza A.
Tue Jun 20 00:00:00 EDT 2017
Chromatin Remodeler Recruitment during Macrophage Differentiation Facilitates Transcription Factor Binding to Enhancers in Mature Cells.
The Journal of biological chemistry
McAndrew MJ,Gjidoda A,Tagore M,Miksanek T,Floer M
17-4801 was used in Flow cytometry/Cell sorting to demonstrate how macrophage-specific gene enhancers are accessible in differentiating macrophages to facilitate induction into mature cells.
Fri Aug 26 00:00:00 EDT 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
17-4801 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
NADPH Oxidases Are Essential for Macrophage Differentiation.
The Journal of biological chemistry
Xu Q,Choksi S,Qu J,Jang J,Choe M,Banfi B,Engelhardt JF,Liu ZG
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of NOX1 and NOX2 in macrophage differentiation and tumor progression.
Fri Sep 16 00:00:00 EDT 2016
Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14.
mBio
Cicchini L,Westrich JA,Xu T,Vermeer DW,Berger JN,Clambey ET,Lee D,Song JI,Lambert PF,Greer RO,Lee JH,Pyeon D
17-4801 was used in Flow cytometry/Cell sorting to investigate the underlying mechanism of immune suppression induced by HPV oncoprotein E7, showing that there is epigenetic downregulation of CXCL14.
Tue May 03 00:00:00 EDT 2016
Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling.
PLoS genetics
Shen H,Yu X,Yang F,Zhang Z,Shen J,Sun J,Choksi S,Jitkaew S,Shu Y
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism of how cancer cells transform normal fibroblasts into cancer-associated fibroblasts.
Mon Aug 01 00:00:00 EDT 2016
Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.
The Journal of biological chemistry
Takegahara N,Kim H,Mizuno H,Sakaue-Sawano A,Miyawaki A,Tomura M,Kanagawa O,Ishii M,Choi Y
17-4801 was used in Flow cytometry/Cell sorting to determine the mechanisms by which polyploidization of osteoclasts are controlled- an essential process for bone-resorbing activity.
Fri Feb 12 00:00:00 EST 2016
Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae.
PLoS neglected tropical diseases
Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils contribute to early anti-filarial host responses via oxidative burst, degranulation and NETosis.
Fri Apr 01 00:00:00 EDT 2016
MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment.
Nature communications
Wilson R,Espinosa-Diez C,Kanner N,Chatterjee N,Ruhl R,Hipfinger C,Advani SJ,Li J,Khan OF,Franovic A,Weis SM,Kumar S,Coussens LM,Anderson DG,Chen CC,Cheresh DA,Anand S
17-4801 was used in Flow cytometry/Cell sorting to demonstrate a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death.
Fri Nov 25 00:00:00 EST 2016
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
17-4801 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Involvement of TGF-β1/Smad3 Signaling in Carbon Tetrachloride-Induced Acute Liver Injury in Mice.
PloS one
Niu L,Cui X,Qi Y,Xie D,Wu Q,Chen X,Ge J,Liu Z
17-4801 was used in Immunofluorescence to study how the activation of TGF-β signaling contributes to the CCl4-induced acute liver injury.
Mon Jul 10 00:00:00 EDT 2017
Adipose tissue macrophages in non-rodent mammals: a comparative study.
Cell and tissue research
Ampem G,Azegrouz H,Bacsadi Á,Balogh L,Schmidt S,Thuróczy J,Röszer T
17-4801-82 was used in Flow cytometry/Cell sorting to show that the presence of ATMs is a general trait of mammals, and that the interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals.
Mon Feb 01 00:00:00 EST 2016
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.
Oncoimmunology
Holmgaard RB,Brachfeld A,Gasmi B,Jones DR,Mattar M,Doman T,Murphy M,Schaer D,Wolchok JD,Merghoub T
17-4801 was used in Flow cytometry/Cell sorting to show that both CSF-1 and its receptor (CSF-1R) are frequently expressed in tumors from cancer patients, and that this expression correlates with tumor-infiltration of MDSCs.
Fri Jul 01 00:00:00 EDT 2016
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Science (New York, N.Y.)
Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW
17-4801 was used in Flow cytometry/Cell sorting to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.
Fri Jul 31 00:00:00 EDT 2015
High salt primes a specific activation state of macrophages, M(Na).
Cell research
Zhang WC,Zheng XJ,Du LJ,Sun JY,Shen ZX,Shi C,Sun S,Zhang Z,Chen XQ,Qin M,Liu X,Tao J,Jia L,Fan HY,Zhou B,Yu Y,Ying H,Hui L,Liu X,Yi X,Liu X,Zhang L,Duan SZ
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms of high salt in disease risk, showing that it primes a specific activation state of macrophages.
Sat Aug 01 00:00:00 EDT 2015
Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.
Nature immunology
Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.
Fri May 01 00:00:00 EDT 2015
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
17-4801 was used in Flow cytometry/Cell sorting to highlight an unexpected tumor suppressive function of IKKβ/NF-κB in CAFs linked to HGF release.
Mon Dec 14 00:00:00 EST 2015
ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.
EMBO molecular medicine
Li C,Li W,Xiao J,Jiao S,Teng F,Xue S,Zhang C,Sheng C,Leng Q,Rudd CE,Wei B,Wang H
17-4801 was used in Flow cytometry/Cell sorting to investigate the effects of the ADAP-SKAP55 signaling module on cytotoxicity, PD-1 expression, and anti-tumour immunity.
Mon Jun 01 00:00:00 EDT 2015
Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.
Molecular psychiatry
Choi EY,Lim JH,Neuwirth A,Economopoulou M,Chatzigeorgiou A,Chung KJ,Bittner S,Lee SH,Langer H,Samus M,Kim H,Cho GS,Ziemssen T,Bdeir K,Chavakis E,Koh JY,Boon L,Hosur K,Bornstein SR,Meuth SG,Hajishengallis G,Chavakis T
17-4801 was used in Flow cytometry/Cell sorting to provide mechanistic underpinnings for the previous implication of Del-1 as a candidate MS susceptibility gene.
Wed Jul 01 00:00:00 EDT 2015
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
Proceedings of the National Academy of Sciences of the United States of America
Hashimoto-Kataoka T,Hosen N,Sonobe T,Arita Y,Yasui T,Masaki T,Minami M,Inagaki T,Miyagawa S,Sawa Y,Murakami M,Kumanogoh A,Yamauchi-Takihara K,Okumura M,Kishimoto T,Komuro I,Shirai M,Sakata Y,Nakaoka Y
17-4801 was used in Flow cytometry/Cell sorting to suggest that IL-21 promotes PAH in association with M2 macrophage polarisation, downstream of IL-6-signalling.
Tue May 19 00:00:00 EDT 2015
Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice.
British journal of cancer
Tanaka Y,Ito S,Oshino R,Chen N,Nishio N,Isobe K
17-4801 was used in Immunofluorescence to investigate how GADD34 up-regulated pro-inflammatory mediator production, leading to a higher tumour burden following AOM/DSS treatment.
Tue Aug 11 00:00:00 EDT 2015
Conditional IL-4/IL-13-deficient mice reveal a critical role of innate immune cells for protective immunity against gastrointestinal helminths.
Mucosal immunology
Oeser K,Schwartz C,Voehringer D
17-4801 was used in Immunohistochemistry to compare the immune response to Nippostrongylus brasiliensis in wild-type, T cell-specific interleukin (IL)-4/IL-13-deficient and general IL-4/IL-13-deficient mice.
Fri May 01 00:00:00 EDT 2015
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.
Journal of virology
Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T
17-4801 was used in Flow cytometry/Cell sorting to demonstrate the enormous functional and genetic plasticity of monocytes infiltrating the liver after inflammation.
Fri May 01 00:00:00 EDT 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
17-4801 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Antimicrobial agents and chemotherapy
Hilliard JJ,Datta V,Tkaczyk C,Hamilton M,Sadowska A,Jones-Nelson O,O'Day T,Weiss WJ,Szarka S,Nguyen V,Prokai L,Suzich J,Stover CK,Sellman BR
17-4801 was used in Flow cytometry/Cell sorting to characterise MEDI4893* and its therapeutic activity in a dermonecrosis model, showing that MEDI4893* and antibiotic combination therapy improves disease outcome.
Thu Jan 01 00:00:00 EST 2015
Quantifying progression and regression of thrombotic risk in experimental atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Palekar RU,Jallouk AP,Goette MJ,Chen J,Myerson JW,Allen JS,Akk A,Yang L,Tu Y,Miller MJ,Pham CT,Wickline SA,Pan H
17-4801 was used in Flow cytometry/Cell sorting to suggest that excessive permeability to PFC-NP may indicate prothrombotic risk in damaged atherosclerotic vasculature, which resolves within weeks after dietary therapy.
Wed Jul 01 00:00:00 EDT 2015
Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis.
Journal of molecular medicine (Berlin, Germany)
Peng H,Li C,Kadow S,Henry BD,Steinmann J,Becker KA,Riehle A,Beckmann N,Wilker B,Li PL,Pritts T,Edwards MJ,Zhang Y,Gulbins E,Grassmé H
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of the mammalian acid sphingomyelinase (Asm)/ceramide system in the development of lung edema caused by S. aureus.
Mon Jun 01 00:00:00 EDT 2015
A novel flow cytometric method to assess inflammasome formation.
Journal of immunology (Baltimore, Md. : 1950)
Sester DP,Thygesen SJ,Sagulenko V,Vajjhala PR,Cridland JA,Vitak N,Chen KW,Osborne GW,Schroder K,Stacey KJ
17-4801 was used in Flow cytometry/Cell sorting to develop an assay for inflammasome formation, time of flight inflammasome evaluation.
Thu Jan 01 00:00:00 EST 2015
Newly recruited CD11b+, GR-1+, Ly6C(high) myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus.
Journal of immunology (Baltimore, Md. : 1950)
Clements DR,Sterea AM,Kim Y,Helson E,Dean CA,Nunokawa A,Coyle KM,Sharif T,Marcato P,Gujar SA,Lee PW
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that reovirus augments tumour-associated immunosuppression immediately following its therapeutic administration.
Fri May 01 00:00:00 EDT 2015
Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.
Molecular and cellular biology
Fabbiano S,Menacho-Márquez M,Robles-Valero J,Pericacho M,Matesanz-Marín A,García-Macías C,Sevilla MA,Montero MJ,Alarcón B,López-Novoa JM,Martín P,Bustelo XR
17-4801 was used in Flow cytometry/Cell sorting to determine that TREG cells constitute a first protective barrier against hypertension-driven tissue fibrosis.
Thu Oct 01 00:00:00 EDT 2015
Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.
Endocrinology
Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA
17-4801 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.
Thu Oct 01 00:00:00 EDT 2015
Numb is required to prevent p53-dependent senescence following skeletal muscle injury.
Nature communications
Le Roux I,Konge J,Le Cam L,Flamant P,Tajbakhsh S
17-4801 was used in Flow cytometry/Cell sorting to provide insights into the mechanisms regulating senescence in regenerating muscle.
Tue Oct 27 00:00:00 EDT 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 EST 2015
The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.
Nature communications
Liao J,Kapadia VS,Brown LS,Cheong N,Longoria C,Mija D,Ramgopal M,Mirpuri J,McCurnin DC,Savani RC
17-4801 was used in Flow cytometry/Cell sorting to monitor the ratio of IL1β:IL1ra within tracheal aspirates from preterm infants during the development of bronchopulmonary dysplasia.
Fri Nov 27 00:00:00 EST 2015
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.
PloS one
Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ
17-4801 was used in Flow cytometry/Cell sorting to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.
Mon Jun 27 00:00:00 EDT 2016
CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype.
Journal of neuroinflammation
Peluffo H,Solari-Saquieres P,Negro-Demontel ML,Francos-Quijorna I,Navarro X,López-Vales R,Sayós J,Lago N
17-4801 was used in Flow cytometry/Cell sorting to show that the pair CD300f ligand is implicated in Wallerian degeneration and nerve regeneration by modulating both the influx and phenotype of macrophages.
Wed Aug 12 00:00:00 EDT 2015
CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.
PloS one
Mazumdar S,Arendt LM,Phillips S,Sedic M,Kuperwasser C,Gill G
17-4801 was used in Immunofluorescence to investigate the tumourigenic mechanism of action of the co-repressor CoREST1.
Tue Feb 09 00:00:00 EST 2016
Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
PloS one
Lee SW,Park HJ,Jeon SH,Lee C,Seong RH,Park SH,Hong S
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of a SWI3-related gene in experimental autoimmune encephalomyelitis development.
Mon Apr 11 00:00:00 EDT 2016
Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.
PloS one
Kumagai K,Tabu K,Sasaki F,Takami Y,Morinaga Y,Mawatari S,Hashimoto S,Tanoue S,Kanmura S,Tamai T,Moriuchi A,Uto H,Tsubouchi H,Ido A
17-4801 was used in Flow cytometry/Cell sorting to identify the immune cells which respond to acute liver injury and assess their contribution to the repair process.
Mon Jun 20 00:00:00 EDT 2016
CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.
Nature communications
Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C
17-4801 was used in Flow cytometry/Cell sorting to show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2-/- mice from impaired muscle regeneration through altering macrophage function.
Thu Dec 03 00:00:00 EST 2015
Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in Mice.
Scientific reports
Yang L,Han Z,Tian L,Mai P,Zhang Y,Wang L,Li L
17-4801 was used in Flow cytometry/Cell sorting to evaluate the effects of S1P on bone marrow-derived monocyte/macrophage migration in mouse models of cholestatic liver injury, and characterise underlying signalling pathways.
Tue Sep 01 00:00:00 EDT 2015
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Nature
Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that tumour-cell-derived lactic acid has an important signalling role in the induction of tumour-associated macrophage polarization.
Thu Sep 25 00:00:00 EDT 2014
Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain.
The Journal of clinical investigation
Old EA,Nadkarni S,Grist J,Gentry C,Bevan S,Kim KW,Mogg AJ,Perretti M,Malcangio M
17-4801 was used in Flow cytometry/Cell sorting to delineate a pathway for pain that is induced by the chemotherapeutic drug vincristine sulphate.
Thu May 01 00:00:00 EDT 2014
12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
The Journal of experimental medicine
Liu M,Saeki K,Matsunobu T,Okuno T,Koga T,Sugimoto Y,Yokoyama C,Nakamizo S,Kabashima K,Narumiya S,Shimizu T,Yokomizo T
17-4801 was used in Flow cytometry/Cell sorting to demonstrate the potential use of BLT2 agonists as therapeutic agents to accelerate wound healing.
Mon Jun 02 00:00:00 EDT 2014
18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling.
The Journal of experimental medicine
Endo J,Sano M,Isobe Y,Fukuda K,Kang JX,Arai H,Arita M
17-4801 was used in Flow cytometry/Cell sorting to study the ability of an eicosapentaenoic acid metabolite to inhibit macrophage-mediated proinflammatory activation of cardiac fibroblasts.
Mon Jul 28 00:00:00 EDT 2014
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
The EMBO journal
Jurkin J,Henkel T,Nielsen AF,Minnich M,Popow J,Kaufmann T,Heindl K,Hoffmann T,Busslinger M,Martinez J
17-4801 was used in Flow cytometry/Cell sorting to investigate the mammalian ligase required for cleavage of XBP1, showing that tRNA ligase complex mediates splicing of XBP1 mRNA.
Wed Dec 17 00:00:00 EST 2014
Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America
Teijaro JR,Walsh KB,Rice S,Rosen H,Oldstone MB
17-4801 was used in Flow cytometry/Cell sorting to show that sphingosine-1-phosphate-1 receptor agonist treatment suppresses global cytokine amplification during influenza virus infection.
Tue Mar 11 00:00:00 EDT 2014
Age-dependent enterocyte invasion and microcolony formation by Salmonella.
PLoS pathogens
Zhang K,Dupont A,Torow N,Gohde F,Leschner S,Lienenklaus S,Weiss S,Brinkmann MM,Kühnel M,Hensel M,Fulde M,Hornef MW
17-4801 was used in Flow cytometry/Cell sorting to provide important insight in the early steps of Salmonella infection in vivo.
Mon Sep 01 00:00:00 EDT 2014
TLR2 signaling decreases transmission of Streptococcus pneumoniae by limiting bacterial shedding in an infant mouse Influenza A co-infection model.
PLoS pathogens
Richard AL,Siegel SJ,Erikson J,Weiser JN
17-4801 was used in Flow cytometry/Cell sorting to suggest that the innate immune response to influenza virus promotes bacterial shedding.
Fri Aug 01 00:00:00 EDT 2014
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
PLoS pathogens
Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NLRP12/NLRP3-dependent activation of caspase-1 is likely to be a key event in mediating systemic production of IL-1β.
Wed Jan 01 00:00:00 EST 2014
CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo.
Stem cell reports
Spike BT,Kelber JA,Booker E,Kalathur M,Rodewald R,Lipianskaya J,La J,He M,Wright T,Klemke R,Wahl GM,Gray PC
17-4801 was used in Immunofluorescence to identify the CRIPTO/GRP78 pathway as a developmentally conserved regulator of fetal and adult mammary stem cell behavior ex vivo.
Tue Apr 08 00:00:00 EDT 2014
Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.
Atherosclerosis
Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ
17-4801 was used in Flow cytometry/Cell sorting to investigate whether a reduction of inducible nitric oxide synthase-mediated oxidative stress remobilises macrophage-derived foam cells and may reverse atherosclerotic plaque formation.
Tue Jul 01 00:00:00 EDT 2014
Development of a culture system to induce microglia-like cells from haematopoietic cells.
Neuropathology and applied neurobiology
Noto D,Sakuma H,Takahashi K,Saika R,Saga R,Yamada M,Yamamura T,Miyake S
17-4801 was used in Flow cytometry/Cell sorting to outline the conditions and factors necessary for the differentiation of microglia from progenitors.
Wed Oct 01 00:00:00 EDT 2014
Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
Journal of leukocyte biology
Bosmann M,Strobl B,Kichler N,Rigler D,Grailer JJ,Pache F,Murray PJ,Müller M,Ward PA
17-4801 was used in Flow cytometry/Cell sorting to investigate factors governing the gene expression and release of IL-27.
Tue Jul 01 00:00:00 EDT 2014
Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.
Laboratory investigation; a journal of technical methods and pathology
Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS
17-4801 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.
Mon Dec 01 00:00:00 EST 2014
Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.
Journal of immunology (Baltimore, Md. : 1950)
Zasłona Z,Przybranowski S,Wilke C,van Rooijen N,Teitz-Tennenbaum S,Osterholzer JJ,Wilkinson JE,Moore BB,Peters-Golden M
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that rAMs dampen, whereas circulating monocytes promote, early events in allergic lung inflammation.
Wed Oct 15 00:00:00 EDT 2014
Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.
Journal of immunology (Baltimore, Md. : 1950)
Bosmann M,Russkamp NF,Strobl B,Roewe J,Balouzian L,Pache F,Radsak MP,van Rooijen N,Zetoune FS,Sarma JV,Núñez G,Müller M,Murray PJ,Ward PA
17-4801 was used in Flow cytometry/Cell sorting to identify IL-10 as a critical suppressing factor for IL-27(p28) production during infection-associated inflammation.
Mon Dec 01 00:00:00 EST 2014
Increase in hypotonic stress-induced endocytic activity in macrophages via ClC-3.
Molecules and cells
Yan Y,Ding Y,Ming B,Du W,Kong X,Tian L,Zheng F,Fang M,Tan Z,Gong F
17-4801 was used in Flow cytometry/Cell sorting to elucidate whether and how hypotonicity affects immune cell function.
Thu May 01 00:00:00 EDT 2014
Itraconazole, a commonly used antifungal, inhibits Fcγ receptor-mediated phagocytosis: alteration of Fcγ receptor glycosylation and gene expression.
Shock (Augusta, Ga.)
Niño DF,Cauvi DM,De Maio A
17-4801 was used in Immunocytochemistry-immunoflourescence to determine the effects of itraconazole on phagocytosis as a major function of macrophages.
Tue Jul 01 00:00:00 EDT 2014
Itraconazole, a commonly used antifungal, inhibits Fcγ receptor-mediated phagocytosis: alteration of Fcγ receptor glycosylation and gene expression.
Shock (Augusta, Ga.)
Niño DF,Cauvi DM,De Maio A
17-4801 was used in Immunocytochemistry-immunoflourescence to determine the effects of itraconazole on phagocytosis as a major function of macrophages.
Tue Jul 01 00:00:00 EDT 2014
Core needle biopsy of breast cancer tumors increases distant metastases in a mouse model.
Neoplasia (New York, N.Y.)
Mathenge EG,Dean CA,Clements D,Vaghar-Kashani A,Photopoulos S,Coyle KM,Giacomantonio M,Malueth B,Nunokawa A,Jordan J,Lewis JD,Gujar SA,Marcato P,Lee PW,Giacomantonio CA
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that CNB creates an immunosuppressive tumour microenvironment, increases EMT, and facilitates release of circulating tumour cells, leading to increased metastases.
Sat Nov 01 00:00:00 EDT 2014
The effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure.
Respiratory research
Jones CV,Alikhan MA,O'Reilly M,Sozo F,Williams TM,Harding R,Jenkin G,Ricardo SD
17-4801 was used in Flow cytometry/Cell sorting to examine the effect of CSF-1 administration on lung maturation in a mouse model of neonatal hyperoxia exposure.
Sat Sep 06 00:00:00 EDT 2014
IKKα negatively regulates ASC-dependent inflammasome activation.
Nature communications
Martin BN,Wang C,Willette-Brown J,Herjan T,Gulen MF,Zhou H,Bulek K,Franchi L,Sato T,Alnemri ES,Narla G,Zhong XP,Thomas J,Klinman D,Fitzgerald KA,Karin M,Nuñez G,Dubyak G,Hu Y,Li X
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of IκB kinase α in inflammasome activation, showing that it negatively regulates ASC-dependent activation.
Tue Sep 30 00:00:00 EDT 2014
The monocyte to macrophage transition in the murine sterile wound.
PloS one
Crane MJ,Daley JM,van Houtte O,Brancato SK,Henry WL,Albina JE
17-4801 was used in Flow cytometry/Cell sorting to examine the origin of wound repair macrophages in sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in mice.
Tue Nov 04 00:00:00 EST 2014
Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.
PloS one
Busch M,Westhofen TC,Koch M,Lutz MB,Zernecke A
17-4801 was used in Flow cytometry/Cell sorting to perform a systematic analysis of dendritic cells and their accumulation characteristics during atherogenesis.
Tue Oct 21 00:00:00 EDT 2014
p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression.
Nature communications
Tian L,Choi SC,Murakami Y,Allen J,Morse HC,Qi CF,Krzewski K,Coligan JE
17-4801 was used in Flow cytometry/Cell sorting to identify the mechanism and role of mouse CD300f in apoptotic cell phagocytosis and the maintenance of immune homeostasis.
Mon Mar 07 00:00:00 EST 2016
Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.
The Journal of biological chemistry
Königs V,Jennings R,Vogl T,Horsthemke M,Bachg AC,Xu Y,Grobe K,Brakebusch C,Schwab A,Bähler M,Knaus UG,Hanley PJ
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that Macrophages lacking Rho proteins migrate faster in vitro, which translates to more rapid in vivo monocyte/macrophage recruitment.
Fri Oct 31 00:00:00 EDT 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
17-4801 was used in Immunofluorescence to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.
Nature immunology
Ji Q,Castelli L,Goverman JM
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the role of CD8(+) T cells in the pathogenesis of multiple sclerosis.
Fri Mar 01 00:00:00 EST 2013
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
Nature immunology
Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF
17-4801 was used in Flow cytometry/Cell sorting to investigate how type-2 immunity is affected by STAT5 transcription factor in dendritic cells.
Mon Apr 01 00:00:00 EDT 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of miR-126 and miR-126* in tumour progression.
Fri Mar 01 00:00:00 EST 2013
p62 links β-adrenergic input to mitochondrial function and thermogenesis.
The Journal of clinical investigation
Müller TD,Lee SJ,Jastroch M,Kabra D,Stemmer K,Aichler M,Abplanalp B,Ananthakrishnan G,Bhardwaj N,Collins S,Divanovic S,Endele M,Finan B,Gao Y,Habegger KM,Hembree J,Heppner KM,Hofmann S,Holland J,Küchler D,Kutschke M,Krishna R,Lehti M,Oelkrug R,Ottaway N,Perez-Tilve D,Raver C,Walch AK,Schriever SC,Speakman J,Tseng YH,Diaz-Meco M,Pfluger PT,Moscat J,Tschöp MH
17-4801 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the role of the scaffold protein p62 in the control of metabolic homeostasis and obesity.
Tue Jan 01 00:00:00 EST 2013
Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.
The Journal of experimental medicine
Schreiber HA,Loschko J,Karssemeijer RA,Escolano A,Meredith MM,Mucida D,Guermonprez P,Nussenzweig MC
17-4801 was used in Flow cytometry/Cell sorting to assess the effect of selective depletion of monocytes and macrophages on immune responses to a bacterial pathogen.
Mon Sep 23 00:00:00 EDT 2013
Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes.
EMBO molecular medicine
Soehnlein O,Drechsler M,Döring Y,Lievens D,Hartwig H,Kemmerich K,Ortega-Gómez A,Mandl M,Vijayan S,Projahn D,Garlichs CD,Koenen RR,Hristov M,Lutgens E,Zernecke A,Weber C
17-4801 was used in Flow cytometry/Cell sorting to investigate the differential role of classical and non-classical leukocytes in atheroprogression under high-fat diet, showing that CXCL1 and CCR1/CCR5 are important in the mobilisation and recruitment of classical monocytes in atheroprogression.
Fri Mar 01 00:00:00 EST 2013
VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.
Molecular therapy : the journal of the American Society of Gene Therapy
Currier MA,Eshun FK,Sholl A,Chernoguz A,Crawford K,Divanovic S,Boon L,Goins WF,Frischer JS,Collins MH,Leddon JL,Baird WH,Haseley A,Streby KA,Wang PY,Hendrickson BW,Brekken RA,Kaur B,Hildeman D,Cripe TP
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that systemic VEGF blockade significantly enhances oncolytic herpes simplex virus virotherapy for cancer by enhancing antiangiogenesis and modulating the innate cellular host response.
Wed May 01 00:00:00 EDT 2013
Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice.
Experimental & molecular medicine
Oh YB,Ahn M,Lee SM,Koh HW,Lee SH,Kim SH,Park BH
17-4801 was used in Flow cytometry/Cell sorting to indicate that the inhibition of JAK3 may reduce inflammation-mediated apoptotic damage from myocardial I/R injury.
Fri May 17 00:00:00 EDT 2013
CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Akhtar S,Gremse F,Kiessling F,Weber C,Schober A
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of CXCL12 in the treatment of unstable atherosclerotic lesions.
Mon Apr 01 00:00:00 EDT 2013
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.
Microbes and infection
Schmitt DM,O'Dee DM,Brown MJ,Horzempa J,Russo BC,Morel PA,Nau GJ
17-4801 was used in Flow cytometry/Cell sorting to investigate role of NK cells against F.tularensis infection in vivo, with LVS-vaccinated murine hosts.
Fri Mar 01 00:00:00 EST 2013
Characterization and evaluation of a new oncolytic vaccinia virus strain LIVP6.1.1 for canine cancer therapy.
Bioengineered
Gentschev I,Patil SS,Adelfinger M,Weibel S,Geissinger U,Frentzen A,Chen NG,Yu YA,Zhang Q,Ogilvie G,Szalay AA
17-4801 was used in Flow cytometry/Cell sorting to demonstrate the efficacy of new VACV strain LIVP6.1.1 for canine cancer therapy.
Wed Sep 04 00:00:00 EDT 2013
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Journal of leukocyte biology
Hutchins NA,Wang F,Wang Y,Chung CS,Ayala A
17-4801 was used in Flow cytometry/Cell sorting to study Kupffer cell-mediated potentiation of liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Fri Nov 01 00:00:00 EDT 2013
Loss of CCR5 results in glucose intolerance in diet-induced obese mice.
American journal of physiology. Endocrinology and metabolism
Kennedy A,Webb CD,Hill AA,Gruen ML,Jackson LG,Hasty AH
17-4801 was used in Flow cytometry/Cell sorting to suggest that CCR5 deficiency impairs systemic glucose tolerance as well as adipose tissue and muscle insulin signaling.
Tue Oct 01 00:00:00 EDT 2013
Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1.
Journal of immunology (Baltimore, Md. : 1950)
Yamazaki C,Sugiyama M,Ohta T,Hemmi H,Hamada E,Sasaki I,Fukuda Y,Yano T,Nobuoka M,Hirashima T,Iizuka A,Sato K,Tanaka T,Hoshino K,Kaisho T
17-4801 was used in Immunohistochemistry to track and ablate CD8α(+) dendritic cells in vivo to gather information on their function and behaviour.
Sat Jun 15 00:00:00 EDT 2013
MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx.
Journal of immunology (Baltimore, Md. : 1950)
Dorrington MG,Roche AM,Chauvin SE,Tu Z,Mossman KL,Weiser JN,Bowdish DM
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that macrophage receptor with collagenous structure is an important component of anti-Streptococcus pneumoniae responses in the murine nasopharynx during colonisation.
Tue Jan 01 00:00:00 EST 2013
Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Dunham RM,Thapa M,Velazquez VM,Elrod EJ,Denning TL,Pulendran B,Grakoui A
17-4801 was used in Flow cytometry/Cell sorting to demonstrate a potential Treg enrichment role for hepatic stellate cells, supporting the tolerogenic nature of the liver.
Fri Mar 01 00:00:00 EST 2013
IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock.
Journal of immunology (Baltimore, Md. : 1950)
Siegfried A,Berchtold S,Manncke B,Deuschle E,Reber J,Ott T,Weber M,Kalinke U,Hofer MJ,Hatesuer B,Schughart K,Gailus-Durner V,Fuchs H,Hrabe de Angelis M,Weber F,Hornef MW,Autenrieth IB,Bohn E
17-4801 was used in Flow cytometry/Cell sorting to study the molecular mechanism by which type I interferon signalling amplifies the secretion of lipopolysaccharide-induced proinflammatory cytokines.
Tue Oct 01 00:00:00 EDT 2013
Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury.
American journal of physiology. Renal physiology
Awad AS,Gao T,Gvritishvili A,You H,Liu Y,Cooper TK,Reeves WB,Tombran-Tink J
17-4801 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of the pigment epithelium-derived factor fragment, P78-PEDF, for diabetic nephropathy.
Sun Sep 15 00:00:00 EDT 2013
CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.
Infection and immunity
Guo Y,Sun X,Shibata K,Yamada H,Muta H,Podack ER,Yoshikai Y
17-4801 was used in Flow cytometry/Cell sorting to demonstrate the involvement of CD30 signalling in the production of IL-17A by γδ T cells following BCG infection.
Tue Oct 01 00:00:00 EDT 2013
Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis.
Infection and immunity
Bonne-Année S,Kerepesi LA,Hess JA,O'Connell AE,Lok JB,Nolan TJ,Abraham D
17-4801 was used in Flow cytometry/Cell sorting to demonstrate a novel function by which alternatively activated macrophages control large extracellular parasites.
Sun Sep 01 00:00:00 EDT 2013
CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury.
Shock (Augusta, Ga.)
Bosmann M,Grailer JJ,Russkamp NF,Ruemmler R,Zetoune FS,Sarma JV,Ward PA
17-4801 was used in Flow cytometry/Cell sorting to investigate the production and downstream effects of IL-23 using a mouse model of lipopolysaccharide-induced acute lung injury.
Wed May 01 00:00:00 EDT 2013
Nitric oxide synthase expression correlates with death in an experimental mouse model of dengue with CNS involvement.
Virology journal
de Souza KP,Silva EG,de Oliveira Rocha ES,Figueiredo LB,de Almeida-Leite CM,Arantes RM,de Assis Silva Gomes J,Ferreira GP,de Oliveira JG,Kroon EG,Campos MA
17-4801 was used in Flow cytometry/Cell sorting to study how the neurovirulence of DENV 3 genotype I is associated with a deleterious role of NOS2 in the brain.
Mon Aug 26 00:00:00 EDT 2013
High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.
PLoS neglected tropical diseases
Aulner N,Danckaert A,Rouault-Hardoin E,Desrivot J,Helynck O,Commere PH,Munier-Lehmann H,Späth GF,Shorte SL,Milon G,Prina E
17-4801 was used in Flow cytometry/Cell sorting to develop a novel phenotypic screening assay using virulent Leishmania amastigotes growing inside primary macrophage to identify new chemical entities with bona fide drug potential.
Thu Nov 14 00:00:00 EST 2013
Nogo-receptor 1 deficiency has no influence on immune cell repertoire or function during experimental autoimmune encephalomyelitis.
PloS one
Litwak SA,Payne NL,Campanale N,Ozturk E,Lee JY,Petratos S,Siatskas C,Bakhuraysah M,Bernard CC
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that NgR1 has little if any effects on the repertoire of immune cells, their activation and trafficking to the CNS.
Fri Sep 19 00:00:00 EDT 2014
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
17-4801 was used in Flow cytometry/Cell sorting to show that apolipoprotein A1 potently suppresses tumour growth and metastasis.
Fri Jul 19 00:00:00 EDT 2013
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.
PloS one
Tkaczyk C,Hamilton MM,Datta V,Yang XP,Hilliard JJ,Stephens GL,Sadowska A,Hua L,O'Day T,Suzich J,Stover CK,Sellman BR
17-4801 was used in Flow cytometry/Cell sorting to investigate the effect of alpha toxin on the immune response against soft tissue infections, showing that alpha toxin suppresses effective innate and adaptive immune responses.
Mon Jun 23 00:00:00 EDT 2014
MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice.
PloS one
Miller AM,Gilchrist DS,Nijjar J,Araldi E,Ramirez CM,Lavery CA,Fernández-Hernando C,McInnes IB,Kurowska-Stolarska M
17-4801 was used in Flow cytometry/Cell sorting to indicate that miR-155 has an important role in regulating lipid metabolism in the liver, hence deregulation could lead to hepatic steatosis in those with diabetes.
Sun Jun 15 00:00:00 EDT 2014
Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.
PloS one
Jupelli M,Shimada K,Chiba N,Slepenkin A,Alsabeh R,Jones HD,Peterson E,Chen S,Arditi M,Crother TR
17-4801 was used in Flow cytometry/Cell sorting to investigate how chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis..
Sat Aug 02 00:00:00 EDT 2014
Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.
Clinical & developmental immunology
Maes W,Verschuere T,Van Hoylandt A,Boon L,Van Gool S
17-4801 was used in Flow cytometry/Cell sorting to evaluate the local elimination of Tregs as a tool for augmentation of the antitumoural response.
Tue Dec 10 00:00:00 EST 2013
Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.
Nature
von Moltke J,Trinidad NJ,Moayeri M,Kintzer AF,Wang SB,van Rooijen N,Brown CR,Krantz BA,Leppla SH,Gronert K,Vance RE
17-4801 was used in Flow cytometry/Cell sorting to identify novel caspase-1 protease functions in vivo using a strategy for cytosolic delivery of bacterial flagellin, a NAIP5 inflammasome ligand.
Thu Oct 04 00:00:00 EDT 2012
Conditional targeting of tumor necrosis factor receptor-associated factor 6 reveals opposing functions of Toll-like receptor signaling in endothelial and myeloid cells in a mouse model of atherosclerosis.
Circulation
Polykratis A,van Loo G,Xanthoulea S,Hellmich M,Pasparakis M
17-4801 was used in Flow cytometry/Cell sorting to study how toll-like receptor-mediated TRAF6 signaling acts in endothelial cells to promote atherosclerosis but displays atheroprotective, antiinflammatory and prosurvival functions in myeloid cells.
Tue Oct 02 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
17-4801 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.
The Journal of experimental medicine
Meredith MM,Liu K,Darrasse-Jeze G,Kamphorst AO,Schreiber HA,Guermonprez P,Idoyaga J,Cheong C,Yao KH,Niec RE,Nussenzweig MC
17-4801 was used in Immunofluorescence to demonstrate that CD11c-expressing non-cDCs make significant contributions to initiating immunity to parasites and tumors.
Mon Jun 04 00:00:00 EDT 2012
Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.
Journal of the American Society of Nephrology : JASN
Schrimpf C,Xin C,Campanholle G,Gill SE,Stallcup W,Lin SL,Davis GE,Gharib SA,Humphreys BD,Duffield JS
17-4801 was used in Flow cytometry/Cell sorting to study the functions for kidney pericytes in microvascular stability.
Tue May 01 00:00:00 EDT 2012
Macrophage p38 mitogen-activated protein kinase activity regulates invariant natural killer T-cell responses during Borrelia burgdorferi infection.
The Journal of infectious diseases
Hawley K,Navasa N,Olson CM,Bates TC,Garg R,Hedrick MN,Conze D,Rincón M,Anguita J
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that p38 mitogen-activated protein kinase-mediated responses are critical components to the immune response to Borrelia burgdorferi.
Sun Jul 15 00:00:00 EDT 2012
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.
PLoS pathogens
Maelfait J,Roose K,Bogaert P,Sze M,Saelens X,Pasparakis M,Carpentier I,van Loo G,Beyaert R
17-4801 was used in Flow cytometry/Cell sorting to examine the role of the ubiquitin-editing protein A20 in the innate immune responses to IAV and other viruses.
Mon Jul 09 00:00:00 EDT 2012
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bosmann M,Sarma JV,Atefi G,Zetoune FS,Ward PA
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that C5a alters the production of cytokines to regulate inflammatory functions.
Sun Apr 01 00:00:00 EDT 2012
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
The American journal of pathology
Piliponsky AM,Chen CC,Rios EJ,Treuting PM,Lahiri A,Abrink M,Pejler G,Tsai M,Galli SJ
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of chymase mouse mast cell protease 4 in a mouse model of sepsis.
Sat Sep 01 00:00:00 EDT 2012
Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.
Journal of immunology (Baltimore, Md. : 1950)
Hasegawa M,Kamada N,Jiao Y,Liu MZ,Núñez G,Inohara N
17-4801 was used in Flow cytometry/Cell sorting to reveal a crucial role for translocated commensals in the recruitment of neutrophils to the C. difficile infected intestine.
Sat Sep 15 00:00:00 EDT 2012
Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950)
Peters NC,Bertholet S,Lawyer PG,Charmoy M,Romano A,Ribeiro-Gomes FL,Stamper LW,Sacks DL
17-4801 was used in Flow cytometry/Cell sorting to assess the immunity generated by recombinant Leishmania polyprotein with GLA vaccination following challenge with L. major.
Thu Nov 15 00:00:00 EST 2012
Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.
Investigative ophthalmology & visual science
Gupta D,Du Y,Piluek J,Jakub AM,Buela KA,Abbott A,Schuman JS,SundarRaj N
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that EP reduces LPS-induced inflammation in the cornea.
Tue Sep 25 00:00:00 EDT 2012
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia.
Experimental gerontology
Boyd AR,Shivshankar P,Jiang S,Berton MT,Orihuela CJ
17-4801 was used in Flow cytometry/Cell sorting to investigate the extent of the impact of age-related deficiencies in Toll-like receptor function.
Sun Jul 01 00:00:00 EDT 2012
Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.
Infection and immunity
Béla SR,Dutra MS,Mui E,Montpetit A,Oliveira FS,Oliveira SC,Arantes RM,Antonelli LR,McLeod R,Gazzinelli RT
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of IRAK4 in Toxoplasma gondii infection, showing that deficiency leads to impaired innate immunity.
Sat Dec 01 00:00:00 EST 2012
MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.
Infection and immunity
Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S
17-4801 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.
Sun Jan 01 00:00:00 EST 2012
Evaluation of in vitro macrophage differentiation during space flight.
Advances in space research : the official journal of the Committee on Space Research (COSPAR)
Ortega MT,Lu N,Chapes SK
17-4801 was used in Flow cytometry/Cell sorting to confirm that space flight can impact the in vitro development of macrophages from mouse bone marrow cells.
Tue May 15 00:00:00 EDT 2012
Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.
PloS one
Gentschev I,Adelfinger M,Josupeit R,Rudolph S,Ehrig K,Donat U,Weibel S,Chen NG,Yu YA,Zhang Q,Heisig M,Thamm D,Stritzker J,Macneill A,Szalay AA
17-4801 was used in Flow cytometry/Cell sorting to describe the establishment of an in vivo model of canine soft tissue sarcoma, allowing preclinical evaluation of oncolytic vaccinia virus for therapy.
Thu Sep 20 00:00:00 EDT 2012
Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.
PloS one
Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS
17-4801 was used in Flow cytometry/Cell sorting to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.
Thu Jun 20 00:00:00 EDT 2013
The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant mice.
PloS one
Bouchery T,Dénécé G,Attout T,Ehrhardt K,Lhermitte-Vallarino N,Hachet-Haas M,Galzi JL,Brotin E,Bachelerie F,Gavotte L,Moulia C,Bain O,Martin C
17-4801 was used in Flow cytometry/Cell sorting to study the dual effect of the CXCL12/CXCR4 axis on the L. sigmodontis life cycle: a host-cell restriction factor for infection, and as a growth factor for worms.
Fri Dec 28 00:00:00 EST 2012
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
17-4801 was used in Flow cytometry/Cell sorting to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.
Thu Mar 28 00:00:00 EDT 2013
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
17-4801 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.
PloS one
Ayna G,Krysko DV,Kaczmarek A,Petrovski G,Vandenabeele P,Fésüs L
17-4801-82 was used in Flow Cytometry to demonstrate that NALP3 performs key upstream functions in inflammasome activation in mouse macrophages engulfing dying autophagic cells.
Tue Nov 27 00:00:00 EST 2012
Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.
European journal of microbiology & immunology
Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D
17-4801 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.
Fri Jun 01 00:00:00 EDT 2012
Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion.
PloS one
Kennedy A,Gruen ML,Gutierrez DA,Surmi BK,Orr JS,Webb CD,Hasty AH
17-4801 was used in Flow cytometry/Cell sorting to investigate the impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion.
Fri Aug 03 00:00:00 EDT 2012
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.
Cell
Teijaro JR,Walsh KB,Cahalan S,Fremgen DM,Roberts E,Scott F,Martinborough E,Peach R,Oldstone MB,Rosen H
17-4801 was used in Flow cytometry/Cell sorting to elucidate cellular and signalling mechanisms that are important in initiating cytokine storm.
Fri Sep 16 00:00:00 EDT 2011
Galectin-9 attenuates acute lung injury by expanding CD14- plasmacytoid dendritic cell-like macrophages.
American journal of respiratory and critical care medicine
Kojima K,Arikawa T,Saita N,Goto E,Tsumura S,Tanaka R,Masunaga A,Niki T,Oomizu S,Hirashima M,Kohrogi H
17-4801 was used in Flow cytometry/Cell sorting to study how Gal-9 attenuates ALI by expanding CD14(-)CD11b(+)Gr-1(+) pDC-like macrophages by preferentially suppressing macrophage functions.
Mon Aug 01 00:00:00 EDT 2011
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.
Blood
McGaha TL,Chen Y,Ravishankar B,van Rooijen N,Karlsson MC
17-4801 was used in Flow cytometry/Cell sorting to support the hypothesis that MZMs are central in the clearance of apoptotic cells to minimize the immunogenicity of autoantigens.
Thu May 19 00:00:00 EDT 2011
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.
The Journal of clinical investigation
Maniati E,Bossard M,Cook N,Candido JB,Emami-Shahri N,Nedospasov SA,Balkwill FR,Tuveson DA,Hagemann T
17-4801 was used in Flow cytometry/Cell sorting to reveal a novel interaction between oncogenic inflammation and the NF-κB pathway.
Thu Dec 01 00:00:00 EST 2011
Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.
The Journal of clinical investigation
Li J,Bessho K,Shivakumar P,Mourya R,Mohanty SK,Dos Santos JL,Miura IK,Porta G,Bezerra JA
17-4801 was used in Flow cytometry/Cell sorting to assess whether Th1-independent mechanisms can activate effector cells to induce biliary atresia.
Tue Nov 01 00:00:00 EDT 2011
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.
Proceedings of the National Academy of Sciences of the United States of America
Enoksson SL,Grasset EK,Hägglöf T,Mattsson N,Kaiser Y,Gabrielsson S,McGaha TL,Scheynius A,Karlsson MC
17-4801 was used in Immunofluorescence to demonstrate a general NKT-mediated mechanism for the regulation of B-cell behaviour in inflammation and autoreactivity.
Tue Dec 20 00:00:00 EST 2011
TLR-2 and TLR-9 are sensors of apoptosis in a mouse model of doxorubicin-induced acute inflammation.
Cell death and differentiation
Krysko DV,Kaczmarek A,Krysko O,Heyndrickx L,Woznicki J,Bogaert P,Cauwels A,Takahashi N,Magez S,Bachert C,Vandenabeele P
17-4801 was used in Flow cytometry/Cell sorting to study the mechanisms used by the innate immune system to sense the immunogenic form of apoptosis induced by anthracycline antibiotics.
Mon Aug 01 00:00:00 EDT 2011
Arginase-2 mediates diabetic renal injury.
Diabetes
Morris SM,Gao T,Cooper TK,Kepka-Lenhart D,Awad AS
17-4801 was used in Flow cytometry/Cell sorting to determine whether renal arginase activity or expression is increased in diabetes and whether arginase plays a role in development of diabetic nephropathy (DN), showing that arginase-2 mediates diabetic renal injury.
Tue Nov 01 00:00:00 EDT 2011
Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.
Diabetes
Gutierrez DA,Kennedy A,Orr JS,Anderson EK,Webb CD,Gerrald WK,Hasty AH
17-4801 was used in Flow cytometry/Cell sorting to determine adipose tissue-specific mechanisms for the delayed impact of CCR2 deficiency on insulin resistance.
Tue Nov 01 00:00:00 EDT 2011
A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages.
PLoS pathogens
Klotz C,Ziegler T,Figueiredo AS,Rausch S,Hepworth MR,Obsivac N,Sers C,Lang R,Hammerstein P,Lucius R,Hartmann S
17-4801 was used in Flow cytometry/Cell sorting to elucidate the signalling events in macrophages triggered by helminth immunomodulator cystatin, showing cytokine signalling is regulated in these macrophages.
Thu Jan 06 00:00:00 EST 2011
Lineage-committed osteoclast precursors circulate in blood and settle down into bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Muto A,Mizoguchi T,Udagawa N,Ito S,Kawahara I,Abiko Y,Arai A,Harada S,Kobayashi Y,Nakamichi Y,Penninger JM,Noguchi T,Takahashi N
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that receptor activator of NF-κB-positive cells isolated from bone marrow and peripheral blood possess characteristics of quiescent osteoclast precursors in mice.
Thu Dec 01 00:00:00 EST 2011
MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bosmann M,Patel VR,Russkamp NF,Pache F,Zetoune FS,Sarma JV,Ward PA
17-4801 was used in Flow cytometry/Cell sorting to study the expression and release of IL-17F and its regulation by the complement system.
Thu Dec 01 00:00:00 EST 2011
Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Jenkinson WE,Parnell SM,Boudil A,Gautreau-Rolland L,Eksteen B,Ezine S,Lane PJ,Jenkinson EJ,Anderson G
17-4801 was used in Flow cytometry/Cell sorting to suggest that the earliest T cell progenitors represent a developmentally homogeneous progenitor pool that ensures the efficient generation of the first cohorts of T cells during thymus development.
Sun May 01 00:00:00 EDT 2011
Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hasegawa M,Yamazaki T,Kamada N,Tawaratsumida K,Kim YG,Núñez G,Inohara N
17-4801 was used in Flow cytometry/Cell sorting to investigate how Nod1 regulates host susceptibility to C. difficile, and how Nod1-mediated neutrophil recruitment may be an important immune response against the pathogen.
Fri Apr 15 00:00:00 EDT 2011
Genetic variation determines mast cell functions in experimental asthma.
Journal of immunology (Baltimore, Md. : 1950)
Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.
Wed Jun 15 00:00:00 EDT 2011
Evaluation of macrophage plasticity in brown and white adipose tissue.
Cellular immunology
Ortega MT,Xie L,Mora S,Chapes SK
17-4801 was used in Flow cytometry/Cell sorting to investigate the impact of white adipose tissue, brown adipose tissue and in vitro cultured adipocytes on C2D macrophage cell plasticity in different microenvironments.
Fri Dec 09 00:00:00 EST 2011
Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.
American journal of physiology. Renal physiology
Awad AS,Kinsey GR,Khutsishvili K,Gao T,Bolton WK,Okusa MD
17-4801 was used in Flow cytometry/Cell sorting to study the mediation of diabetic renal injury by monocyte/macrophage chemokine receptor CCR2.
Thu Dec 01 00:00:00 EST 2011
Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.
Infection and immunity
Frazer LC,O'Connell CM,Andrews CW,Zurenski MA,Darville T
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of neutrophils in chlamydia-induced pathology.
Sat Oct 01 00:00:00 EDT 2011
Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.
Infection and immunity
Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.
Tue Mar 01 00:00:00 EST 2011
Prolonged chemokine expression and excessive neutrophil infiltration in the lungs of burn-injured mice exposed to ethanol and pulmonary infection.
Shock (Augusta, Ga.)
Murdoch EL,Karavitis J,Deburghgraeve C,Ramirez L,Kovacs EJ
17-4801 was used in Flow cytometry/Cell sorting to examine the cellular composition at 24 and 48 h in the circulation and the alveoli of infected mice given alcohol and burn.
Fri Apr 01 00:00:00 EDT 2011
Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.
The Journal of surgical research
Schneider DF,Palmer JL,Tulley JM,Kovacs EJ,Gamelli RL,Faunce DE
17-4801 was used in Flow cytometry/Cell sorting to explore the effects of purposefully inhibiting natural killer T cell activation on the response to injury.
Tue Nov 01 00:00:00 EDT 2011
Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection.
Parasite immunology
Svensson M,Bell L,Little MC,DeSchoolmeester M,Locksley RM,Else KJ
17-4801 was used in Flow cytometry/Cell sorting to study the accumulation of eosinophils in intestine-draining mesenteric lymph nodes following Trichuris muris infection.
Sat Jan 01 00:00:00 EST 2011
Efficient colonization and therapy of human hepatocellular carcinoma (HCC) using the oncolytic vaccinia virus strain GLV-1h68.
PloS one
Gentschev I,Müller M,Adelfinger M,Weibel S,Grummt F,Zimmermann M,Bitzer M,Heisig M,Zhang Q,Yu YA,Chen NG,Stritzker J,Lauer UM,Szalay AA
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the GLV-1h68 vaccinia virus may have an enormous potential for treatment of human hepatocellular carcinoma in man.
Tue Nov 15 00:00:00 EST 2011
Measurement of tumor cytolysis by macrophages.
Current protocols in immunology
Escórcio-Correia M,Hagemann T
17-4801-82 was used in Flow cytometry/Cell sorting to describe two different protocols for the measurement of tumor cytolysis by macrophages.
Tue Feb 01 00:00:00 EST 2011
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Blood
Huber S,Hoffmann R,Muskens F,Voehringer D
17-4801 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.
Thu Oct 28 00:00:00 EDT 2010
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN
Bajwa A,Jo SK,Ye H,Huang L,Dondeti KR,Rosin DL,Haase VH,Macdonald TL,Lynch KR,Okusa MD
17-4801 was used in Flow cytometry/Cell sorting to investigate the effects of sphingosine-1-phosphate receptor agonists on acute kidney injury.
Tue Jun 01 00:00:00 EDT 2010
Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.
The American journal of pathology
Piliponsky AM,Chen CC,Grimbaldeston MA,Burns-Guydish SM,Hardy J,Kalesnikoff J,Contag CH,Tsai M,Galli SJ
17-4801 was used in Flow cytometry/Cell sorting to investigate the roles of mast cells and their derived proteins in two models of severe bacterial infection.
Mon Feb 01 00:00:00 EST 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
17-4801 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Carrigan SO,Junkins R,Yang YJ,Macneil A,Richardson C,Johnston B,Lin TJ
17-4801 was used in Flow cytometry/Cell sorting to investigate host defence mechanisms involved in P. aeruginosa lung infection.
Wed Sep 15 00:00:00 EDT 2010
The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice.
Toxicology letters
Martin-Murphy BV,Holt MP,Ju C
17-4801 was used in Flow cytometry/Cell sorting to show that damage associated molecular pattern molecules released from damaged and necrotic hepatocytes may link the initial hepatocyte damage and the activation of innate immune cells following Acetaminophen-exposure.
Mon Feb 15 00:00:00 EST 2010
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.
Gastroenterology
Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA
17-4801 was used in Flow cytometry/Cell sorting to study the importance of the chemokine binding protein M3 in enabling distribution of leukocytes throughout the intestine.
Tue Sep 01 00:00:00 EDT 2009
An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.
The Journal of clinical investigation
Tieu BC,Lee C,Sun H,Lejeune W,Recinos A,Ju X,Spratt H,Guo DC,Milewicz D,Tilton RG,Brasier AR
17-4801 was used in Flow cytometry/Cell sorting to identify a vascular inflammatory pathway that contributes to the development of cardiovascular disease.
Tue Dec 01 00:00:00 EST 2009
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN
Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD
17-4801 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.
Sat Aug 01 00:00:00 EDT 2009
Vector transmission of leishmania abrogates vaccine-induced protective immunity.
PLoS pathogens
Peters NC,Kimblin N,Secundino N,Kamhawi S,Lawyer P,Sacks DL
17-4801 was used in Flow cytometry/Cell sorting to identify the critical immunological factors influencing vaccine efficacy following natural transmissions of Leishmania.
Mon Jun 01 00:00:00 EDT 2009
Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
Journal of immunology (Baltimore, Md. : 1950)
Buhtoiarov IN,Rakhmilevich AL,Lanier LL,Ranheim EA,Sondel PM
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms of tumour-macrophage interactions leading to macrophage activation, showing that activation follows ligation of CD40, NKG2D, and CD18 molecules.
Sun Feb 15 00:00:00 EST 2009
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SW,Salek-Ardakani S,Mittler RS,Croft M
17-4801 was used in Flow cytometry/Cell sorting to investigate the potential side effects of immunotherapeutic strategies using Abs against costimulatory molecules.
Mon Jun 01 00:00:00 EDT 2009
Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.
Journal of immunology (Baltimore, Md. : 1950)
Wu W,Mehta H,Chakrabarty K,Booth JL,Duggan ES,Patel KB,Ballard JD,Coggeshall KM,Metcalf JP
17-4801 was used in Flow cytometry/Cell sorting to study how mature and differentiated AM are relatively resistant to the effects of LT as compared with mouse RAW 264.7 macrophages.
Sun Nov 01 00:00:00 EDT 2009
Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin.
Journal of immunology (Baltimore, Md. : 1950)
Wu W,Mehta H,Chakrabarty K,Booth JL,Duggan ES,Patel KB,Ballard JD,Coggeshall KM,Metcalf JP
17-4801 was used in Flow cytometry/Cell sorting to study how mature and differentiated AM are relatively resistant to the effects of LT as compared with mouse RAW 264.7 macrophages.
Sun Nov 01 00:00:00 EDT 2009
An innate response to allogeneic nonself mediated by monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Zecher D,van Rooijen N,Rothstein DM,Shlomchik WD,Lakkis FG
17-4801 was used in Flow cytometry/Cell sorting to investigate how innate immune system distinguishes self-tissues from those of other members of the same species.
Tue Dec 15 00:00:00 EST 2009
Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Stewart TJ,Liewehr DJ,Steinberg SM,Greeneltch KM,Abrams SI
17-4801 was used in Flow cytometry/Cell sorting to investigate the intrinsic molecular events that drive myeloid-derived suppressor cell protumorigenic behavior.
Wed Jul 01 00:00:00 EDT 2009
Shifts in bone marrow cell phenotypes caused by spaceflight.
Journal of applied physiology (Bethesda, Md. : 1985)
Ortega MT,Pecaut MJ,Gridley DS,Stodieck LS,Ferguson V,Chapes SK
17-4801 was used in Flow cytometry/Cell sorting to determine how spaceflight affects differentiation of cells in the granulocytic lineage in mice.
Sun Feb 01 00:00:00 EST 2009
Lymphocytes serve as a reservoir for Listeria monocytogenes growth during infection of mice.
Microbial pathogenesis
McElroy DS,Ashley TJ,D'Orazio SE
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that intracellular L. monocytogenes can survive and multiply in vitro in a variety of transformed cell lines of lymphocytic origin.
Wed Apr 01 00:00:00 EDT 2009
Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy.
PloS one
Dace DS,Khan AA,Stark JL,Kelly J,Cross AH,Apte RS
17-4801 was used in Immunohistochemistry on paraffin embedded tissues to investigate the conditions contributing to the development of CIDP and related conditions.
Tue Sep 22 00:00:00 EDT 2009
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology
Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M
17-4801 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.
Fri Aug 01 00:00:00 EDT 2008
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.
Hepatology (Baltimore, Md.)
You Q,Cheng L,Kedl RM,Ju C
17-4801 was used in Flow cytometry/Cell sorting to examine the ability of Kupffer cells to present antigens and to suppress T cell activation by splenic dendritic cells.
Mon Sep 01 00:00:00 EDT 2008
CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
Journal of the American Society of Nephrology : JASN
Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR
17-4801 was used in Flow cytometry/Cell sorting to identify additional therapeutic chemokine targets for immune-mediated nephritis.
Sun Jun 01 00:00:00 EDT 2008
Diversity of interferon gamma and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis.
Molecular medicine (Cambridge, Mass.)
Flohé SB,Agrawal H,Flohé S,Rani M,Bangen JM,Schade FU
17-4801 was used in Flow cytometry/Cell sorting to test potential immunomodulatory approaches to restore the function of dendritic cells and macrophages during polymicrobial sepsis.
Mon Aug 11 00:00:00 EDT 2008
Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.
Journal of immunology (Baltimore, Md. : 1950)
Menke J,Hsu MY,Byrne KT,Lucas JA,Rabacal WA,Croker BP,Zong XH,Stanley ER,Kelley VR
17-4801 was used in Flow cytometry/Cell sorting to investigate the role of UVB in cutaneous lupus erythematosus, showing that UVB triggers it through a CSF-1-dependent, macrophage-mediated mechanism.
Sat Nov 15 00:00:00 EST 2008
NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection.
Journal of immunology (Baltimore, Md. : 1950)
Wesselkamper SC,Eppert BL,Motz GT,Lau GW,Hassett DJ,Borchers MT
17-4801 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms of NKG2D-mediated clearance of P. aeruginosa.
Wed Oct 15 00:00:00 EDT 2008
G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.
Cellular microbiology
Ingersoll MA,Kline KA,Nielsen HV,Hultgren SJ
17-4801 was used in Flow cytometry/Cell sorting to investigate the mechanism of recruitment of neutrophils to the bladder during urinary tract infection, showing that G-CSF induction early in infection modulates host immunity.
Mon Dec 01 00:00:00 EST 2008
Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response.
Infection and immunity
Guerrero A,Fries BC
17-4801 was used in Flow cytometry/Cell sorting to compare survival rates and characterise the host responses of C. neoformans-resistant mice.
Mon Sep 01 00:00:00 EDT 2008
Hypercholesterolemia impairs immunity to tuberculosis.
Infection and immunity
Martens GW,Arikan MC,Lee J,Ren F,Vallerskog T,Kornfeld H
17-4801 was used in Flow cytometry/Cell sorting to show that ApoE(-/-) deficiency is associated with delayed expression of adaptive immunity to tuberculosis caused by elevated serum cholesterol.
Fri Aug 01 00:00:00 EDT 2008
Tuberculosis susceptibility of diabetic mice.
American journal of respiratory cell and molecular biology
Martens GW,Arikan MC,Lee J,Ren F,Greiner D,Kornfeld H
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that control of Mycobacterium tuberculosis infection is impaired by chronic diabetes.
Thu Nov 01 00:00:00 EDT 2007
Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues.
Molecular and cellular biology
Meuter S,Schaerli P,Roos RS,Brandau O,Bösl MR,von Andrian UH,Moser B
17-4801 was used in Flow cytometry/Cell sorting to investigate the process of dendritic cell recruitment to peripheral tissues, showing that murine CXCL14 is dispensable for dendritic cell function and localisation.
Thu Feb 01 00:00:00 EST 2007
Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment.
Immunity
Nagai Y,Garrett KP,Ohta S,Bahrun U,Kouro T,Akira S,Takatsu K,Kincade PW
17-4801 was used in Flow cytometry/Cell sorting to investigate the expression of toll-like receptors on different hematopoietic stem cells and the mechanism by which they stimulate innate immune system replenishment.
Thu Jun 01 00:00:00 EDT 2006
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.
American journal of physiology. Renal physiology
Awad AS,Ye H,Huang L,Li L,Foss FW,Macdonald TL,Lynch KR,Okusa MD
17-4801 was used in Flow cytometry/Cell sorting to demonstrate that the protective effect of FTY-720 is due primarily to activation of S1P1 receptors.
Thu Jun 01 00:00:00 EDT 2006
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology
Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ
Sat Oct 01 00:00:00 EDT 2005
