Product References
Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.
British journal of pharmacology
Liu LW,Xie Y,Li GQ,Zhang T,Sui YH,Zhao ZJ,Zhang YY,Yang WB,Geng XL,Xue DB,Chen H,Wang YW,Lu TQ,Shang LR,Li ZB,Li L,Sun B
25-4801-82 was used in Flow cytometry/Cell sorting to investigate the effect of gut microbiota and microbiota-derived metabolites on AP and further clarify the mechanisms associated with pancreatic damage and inflammation.
Wed Mar 01 00:00:00 EST 2023
Dipeptidyl peptidase 4 inhibitor reduces tumor-associated macrophages and enhances anti-PD-L1-mediated tumor suppression in non-small cell lung cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Zuo B,Li T,Liu X,Wang S,Cheng J,Liu X,Cui W,Shi H,Ling C
25-4801-82 was used in Flow cytometry/Cell sorting to evaluate the combination of a DPP4 inhibitor (anagliptin) and PD-L1 blockade in an NSCLC mouse model.
Wed Nov 01 00:00:00 EDT 2023
SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization.
Journal of advanced research
Lee JH,Lee SH,Lee EH,Cho JY,Song DK,Lee YJ,Kwon TK,Oh BC,Cho KW,Osborne TF,Jeon TI,Im SS
25-4801-82 was used in Flow Cytometry to examined the function of Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) in high-fat/high-sucrose diet (HFHS)-fed mice and investigated its role in the polarization of classical activated macrophages in adipose tissue.
Wed Mar 01 00:00:00 EST 2023
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
25-4801-82 was used in Flow cytometry/Cell sorting to show that platelet factors transfer the benefits of young blood to the ageing brain.
Tue Aug 01 00:00:00 EDT 2023
Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice.
International journal of molecular sciences
Chung KJ,Legaki AI,Papadopoulos G,Gercken B,Gebler J,Schwabe RF,Chavakis T,Chatzigeorgiou A
25-4801-82 was used in Flow cytometry/Cell sorting to study the role of the pro-inflammatory adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) in HSCs in NASH.
Thu Mar 02 00:00:00 EST 2023
Molecular Imaging of Oxygenation Changes during Immunotherapy in Combination with Paclitaxel in Triple Negative Breast Cancer.
Biomedicines
Napier TS,Lynch SE,Lu Y,Song PN,Burns AC,Sorace AG
25-4801-82 was used in Flow cytometry/Cell sorting to provide insights into how PEF protein dynamics affect secretion of important physiological cargoes such as collagen I and significantly impact ER stress.
Wed Jan 04 00:00:00 EST 2023
TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis.
Nature metabolism
Zhang K,Wang Y,Chen S,Mao J,Jin Y,Ye H,Zhang Y,Liu X,Gong C,Cheng X,Huang X,Hoeft A,Chen Q,Li X,Fang X
25-4801-82 was used in Flow cytometry/Cell sorting to suggest that the modulation of TREM2hi Mac1 cells could serve as a therapeutic strategy for sepsis-induced cardiomyopathy (SICM).
Sun Jan 01 00:00:00 EST 2023
The cephalic phase of insulin release is modulated by IL-1β.
Cell metabolism
Wiedemann SJ,Trimigliozzi K,Dror E,Meier DT,Molina-Tijeras JA,Rachid L,Le Foll C,Magnan C,Schulze F,Stawiski M,Häuselmann SP,Méreau H,Böni-Schnetzler M,Donath MY
25-4801-82 was used in Flow cytometry/Cell sorting to describe that this incretin-like effect of IL-1β involves neuronal transmission.
Tue Jul 05 00:00:00 EDT 2022
ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.
Cell death & disease
Grube J,Woitok MM,Mohs A,Erschfeld S,Lynen C,Trautwein C,Otto T
25-4801-82 was used in Flow cytometry/Cell sorting to investigate the role of ferroptosis, a type of programmed cell death involving iron-dependent peroxidation of membrane phospholipids, in liver cancer (hepatocellular carcinoma) using mouse models of chronic injury-dependent HCC formation.
Sat Aug 13 00:00:00 EDT 2022
NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.
Cells
Mainz RE,Albers S,Haque M,Sonntag R,Treichel NS,Clavel T,Latz E,Schneider KM,Trautwein C,Otto T
25-4801-82 was used in Flow cytometry/Cell sorting to evaluate a novel mouse model for ALD characterized by 8-week chronic-plus-binge ethanol administration and to investigate the role of NLRP6 inflammasome for intestinal homeostasis and ALD progression using Nlrp6-/- mice.
Thu Jan 06 00:00:00 EST 2022
Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis.
Cell death & disease
Ding Y,Gong P,Jiang J,Feng C,Li Y,Su X,Bai X,Xu C,Liu C,Yang J,Fang J,Ji X,Chen Y,Li P,Guo L,Shao C,Shi Y
25-4801-82 was used in Flow cytometry/Cell sorting to find that subcutaneous application of umbilical cord-derived MSCs-IT exhibit remarkable TSG-6-mediated therapeutic efficacy on imiquimod (IMQ)-induced psoriasis-like inflammation in mice.
Fri Nov 25 00:00:00 EST 2022
A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis.
Immunology and cell biology
Zhang L,Feng X,Shen Y,Wang Y,Liu Z,Ma Y,Gu Y,Guo G,Duan L,Lu L,Liang Y,Lawrence T,Huang R
25-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that the ZsGreen-expressing YUMM1.7 melanoma model provides a valuable tool for the study of phagocytosis in vivo.
Sat Oct 01 00:00:00 EDT 2022
Host lung microbiota promotes malaria-associated acute respiratory distress syndrome.
Nature communications
Mukherjee D,Chora ÂF,Lone JC,Ramiro RS,Blankenhaus B,Serre K,Ramirez M,Gordo I,Veldhoen M,Varga-Weisz P,Mota MM
25-4801-82 was used in Flow cytometry/Cell sorting to show that the host microbiota is a contributing factor for the development of respiratory distress syndrome and host mortality in the context of malaria infections (malaria-associated acute respiratory distress syndrome, MA-ARDS).
Wed Jun 29 00:00:00 EDT 2022
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
25-4801-82 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 EDT 2022
Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.
Nature communications
Klapproth E,Witt A,Klose P,Wiedemann J,Vavilthota N,Künzel SR,Kämmerer S,Günscht M,Sprott D,Lesche M,Rost F,Dahl A,Rauch E,Kattner L,Weber S,Mirtschink P,Kopaliani I,Guan K,Lorenz K,Saftig P,Wagner M,El-Armouche A
25-4801-82 was used in Flow cytometry/Cell sorting to demonstrate distinct role of (ADAM10)/CX3CL1 axis in the regulation of neutrophil recruitment early after MI towards improved prognosis.
Sat Dec 10 00:00:00 EST 2022
Circadian Dependence of the Acute Immune Response to Myocardial Infarction.
Frontiers in pharmacology
Kilgallen AB,van den Akker F,Feyen DAM,Crnko S,Snijders Blok CJB,Gremmels H,du Pré BC,Reijers R,Doevendans PA,de Jager SCA,Sluijter JPG,Sampaio-Pinto V,van Laake LW
25-4801-82 was used in Flow cytometry/Cell sorting to characterize the immune response and myocardial damage 3 hours after a MI occurs over a full twenty-four-hour period to investigate the role of the circadian rhythms in this response.
Sat Sep 16 00:00:00 EDT 2023
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.
Nature communications
Schneider KM,Mohs A,Gui W,Galvez EJC,Candels LS,Hoenicke L,Muthukumarasamy U,Holland CH,Elfers C,Kilic K,Schneider CV,Schierwagen R,Strnad P,Wirtz TH,Marschall HU,Latz E,Lelouvier B,Saez-Rodriguez J,de Vos W,Strowig T,Trebicka J,Trautwein C
25-4801-82 was used in Flow cytometry/Cell sorting to demonstrate that gut microbiota closely shapes the hepatic inflammatory microenvironment opening approaches for cancer prevention and therapy.
Fri Jul 08 00:00:00 EDT 2022
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Cell metabolism
Wang L,Wang B,Gasek NS,Zhou Y,Cohn RL,Martin DE,Zuo W,Flynn WF,Guo C,Jellison ER,Kim T,Prata LGPL,Palmer AK,Li M,Inman CL,Barber LS,Al-Naggar IMA,Zhou Y,Du W,Kuchel GA,Meves A,Tchkonia T,Kirkland JL,Robson P,Xu M
25-4801-82 was used in Flow cytometry/Cell sorting to establish that p21high cells within fat are sufficient to cause insulin resistance in vivo.
Tue Jan 04 00:00:00 EST 2022
The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Molecular cell
Huang Z,Liang N,Goñi S,Damdimopoulos A,Wang C,Ballaire R,Jager J,Niskanen H,Han H,Jakobsson T,Bracken AP,Aouadi M,Venteclef N,Kaikkonen MU,Fan R,Treuter E
25-4801-82 was used in Flow Cytometry to investigate a corepressor complex containing GPS2 and SMRT both genome-wide and at the Ccl2 locus, encoding the chemokine CCL2 (MCP-1).
Thu Mar 04 00:00:00 EST 2021
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
The EMBO journal
Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M
25-4801-82 was used in Flow Cytometry to examine myeloid subsets in distinct parts of the eye during homeostasis.
Mon Mar 15 00:00:00 EDT 2021
Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer.
Acta pharmacologica Sinica
Deng Y,Hu JC,He SH,Lou B,Ding TB,Yang JT,Mo MG,Ye DY,Zhou L,Jiang XC,Yu K,Dong JB
25-4801-82 was used in Flow Cytometry to reveal a novel and important role of SMS2 in the protumorigenic function and may offer a new strategy for macrophage-targeted anticancer therapy.
Fri Jan 01 00:00:00 EST 2021
ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages.
Arteriosclerosis, thrombosis, and vascular biology
Kothari V,Tang J,He Y,Kramer F,Kanter JE,Bornfeldt KE
25-4801-82 was used in Flow cytometry/Cell sorting to demonstrate a novel role for ADAM17 in maintaining cholesterol efflux in macrophages, thereby regulating the immune functions of these cells.
Tue Jun 01 00:00:00 EDT 2021
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.
Immunobiology
Yau E,Chen Y,Song C,Webb J,Carillo M,Kawasawa YI,Tang Z,Takahashi Y,Umstead TM,Dovat S,Chroneos ZC
25-4801-82 was used in Flow Cytometry to suggest that the inflammatory differences seen in SP-R210L-deficient macrophages are a result of transcriptional differences that are mediated by epigenetic changes brought about by differential expression of the SP-R210 isoforms.
Mon Nov 01 00:00:00 EDT 2021
Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance.
iScience
Takai J,Shimada T,Nakamura T,Engel JD,Moriguchi T
25-4801-82 was used in Flow Cytometry to examine Gata2-heterozygous mutant (G2 Het) mice as a model for human GATA2 haploinsufficiency.
Fri Aug 20 00:00:00 EDT 2021
Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice.
Science translational medicine
Willis E,Pardi N,Parkhouse K,Mui BL,Tam YK,Weissman D,Hensley SE
25-4801-82 was used in Flow Cytometry to demonstrate that influenza virus-specific maternal antibodies inhibited de novo antibody responses in mouse pups elicited by influenza virus infection or administration of conventional influenza vaccines.
Wed Jan 08 00:00:00 EST 2020
BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B,Harbeson DJ,Shannon CP,Cai B,He D,Ben-Othman R,Francis F,Huang J,Varankovich N,Liu A,Bao W,Bjerregaard-Andersen M,Schaltz-Buchholzer F,Sanca L,Golding CN,Larsen KL,Levy O,Kampmann B,Tan R,Charles A,Wynn JL,Shann F,Aaby P,Benn CS,Tebbutt SJ,Kollmann TR,Amenyogbe N
25-4801 was used in Flow cytometry/Cell sorting to show that BCG was also protective in a mouse model of neonatal polymicrobial sepsis, where it induced granulocyte colony-stimulating factor (G-CSF) within hours of administration.
Wed May 06 00:00:00 EDT 2020
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model.
The Journal of experimental medicine
Reed-Geaghan EG,Croxford AL,Becher B,Landreth GE
25-4801 was used in Flow cytometry/Cell sorting to genetically label different myeloid populations and unequivocally demonstrate that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia.
Mon Apr 06 00:00:00 EDT 2020
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Proceedings of the National Academy of Sciences of the United States of America
Kitchen GB,Cunningham PS,Poolman TM,Iqbal M,Maidstone R,Baxter M,Bagnall J,Begley N,Saer B,Hussell T,Matthews LC,Dockrell DH,Durrington HJ,Gibbs JE,Blaikley JF,Loudon AS,Ray DW
25-4801-82 was used in Flow Cytometry to show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia.
Tue Jan 21 00:00:00 EST 2020
RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis.
Cell death and differentiation
Chen H,Li Y,Wu J,Li G,Tao X,Lai K,Yuan Y,Zhang X,Zou Z,Xu Y
25-4801-82 was used in Flow Cytometry to demonstrate that RIPK3-mediated necroptosis and GSDMD-mediated pyroptosis collaborated to amply inflammatory signaling and enhance tissue injury in the process of sepsis, which may shed new light on two potential targets of combined therapeutic interventions for this highly lethal disorder.
Tue Sep 01 00:00:00 EDT 2020
Enzalutamide, an Androgen Receptor Antagonist, Enhances Myeloid Cell-Mediated Immune Suppression and Tumor Progression.
Cancer immunology research
Consiglio CR,Udartseva O,Ramsey KD,Bush C,Gollnick SO
25-4801 was used in Flow cytometry/Cell sorting to investigate how AR antagonism affects myeloid cell function and metabolism in an AR-independent murine colon tumor model.
Tue Sep 01 00:00:00 EDT 2020
Evaluation of two methods to isolate Schwann cells from murine sciatic nerve.
Journal of neuroscience methods
Tomlinson JE,Golshadi M,Donahue CJ,Dong L,Cheetham J
25-4801 was used in Flow cytometry/Cell sorting to present two techniques to enrich schwann cells (SC) from other cell populations at the site of peripheral nerve injury.
Sat Feb 01 00:00:00 EST 2020
Transient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases After Intravenous Inoculation in Athymic Mice.
Journal of adolescent and young adult oncology
Harris MA,Hons B,Shekhar TM,Coupland LA,Miles MA,Hawkins CJ
25-4801-82 was used in Flow Cytometry to show that transient Natural Killer cell depletion dramatically enhanced the efficiency of experimental pulmonary osteosarcoma metastasis.
Tue Dec 01 00:00:00 EST 2020
Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway.
Scientific reports
Xue Y,Deng Q,Zhang Q,Ma Z,Chen B,Yu X,Peng H,Yao S,Liu J,Ye Y,Pan G
25-4801-82 was used in Flow cytometry/Cell sorting to elucidate a comprehensive profile of AA metabolites during hepatic inflammation caused by CCl4, highlighting the role of 12-LOX-12-HETE pathway in this process. Gigantol alleviated liver inflammation partly through inhibiting the JNK/cPLA2/12-LOX pathway.
Thu Dec 17 00:00:00 EST 2020
Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.
Cell reports
Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R
25-4801 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.
Tue Feb 04 00:00:00 EST 2020
Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.
Scientific reports
Bonfanti AP,Barreto N,Munhoz J,Caballero M,Cordeiro G,Rocha-E-Silva T,Sutti R,Moura F,Brunetto S,Ramos CD,Thomé R,Verinaud L,Rapôso C
25-4801-82 was used in Flow cytometry/Cell sorting to investigate the effect of Phoneutria nigriventer (PnV) on tumor development in vivo.
Fri Apr 03 00:00:00 EDT 2020
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension.
Nature communications
Oh J,Matkovich SJ,Riek AE,Bindom SM,Shao JS,Head RD,Barve RA,Sands MS,Carmeliet G,Osei-Owusu P,Knutsen RH,Zhang H,Blumer KJ,Nichols CG,Mecham RP,Baldán Á,Benitez BA,Sequeira-Lopez ML,Gomez RA,Bernal-Mizrachi C
25-4801 was used in Flow cytometry/Cell sorting to confirm that macrophage miR-106b-5p secretion from impaired vitamin D receptor signalling causes inflammation-induced hypertension.
Wed Sep 23 00:00:00 EDT 2020
Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression.
Frontiers in immunology
Van Bockstal L,Bulté D,Van den Kerkhof M,Dirkx L,Mabille D,Hendrickx S,Delputte P,Maes L,Caljon G
25-4801-82 was used in Flow Cytometry to assess the impact of type I IFN on macrophage infection with L. infantum and L. donovani and the implication of sialoadhesin as an IFN-inducible surface receptor.
Fri Apr 02 00:00:00 EDT 2021
New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes.
NPJ vaccines
Amacker M,Smardon C,Mason L,Sorrell J,Jeffery K,Adler M,Bhoelan F,Belova O,Spengler M,Punnamoottil B,Schwaller M,Bonduelle O,Combadière B,Stegmann T,Naylor A,Johnson R,Wong D,Fleury S
25-4801 was used in Flow cytometry/Cell sorting to develop "ready to use and all-in-one" thermostable needle-free mucosal vaccines using HIV-1 gp41 virosomes.
Fri Dec 17 00:00:00 EST 2021
Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.
NPJ vaccines
Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M
25-4801 was used in Flow cytometry/Cell sorting to find that blocking IL-4 improved the efficacy of vaccines targeting oxycodone and fentanyl in male and female mice.
Thu Oct 29 00:00:00 EDT 2020
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer.
Journal of hematology & oncology
Lu CS,Shiau AL,Su BH,Hsu TS,Wang CT,Su YC,Tsai MS,Feng YH,Tseng YL,Yen YT,Wu CL,Shieh GS
25-4801 was used in Flow cytometry/Cell sorting to indicate that Oct4 expressed by lung cancer cells promotes M2 macrophage polarization through upregulation of M-CSF secretion, leading to cancer growth and metastasis.
Mon Jun 01 00:00:00 EDT 2020
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.
Redox biology
Xu F,Guo M,Huang W,Feng L,Zhu J,Luo K,Gao J,Zheng B,Kong LD,Pang T,Wu X,Xu Q
25-4801 was used in Flow cytometry/Cell sorting to show a novel function of annexin A5 in hepatic macrophage polarization and HFD-induced nonalcoholic steatohepatitis.
Tue Sep 01 00:00:00 EDT 2020
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.
Nature communications
Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A
25-4801 was used in Flow cytometry/Cell sorting to show that during obesity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance and impaired glucose and lipid metabolism.
Fri Jul 24 00:00:00 EDT 2020
Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
eLife
Kim EH,Woodruff MC,Grigoryan L,Maier B,Lee SH,Mandal P,Cortese M,Natrajan MS,Ravindran R,Ma H,Merad M,Gitlin AD,Mocarski ES,Jacob J,Pulendran B
25-4801 was used in Flow cytometry/Cell sorting to demonstrate that squalene emulsion-based vaccine adjuvants induce antigen-specific CD8 T cell and antibody responses, through RIPK3-dependent and-independent pathways, respectively.
Tue Jun 09 00:00:00 EDT 2020
MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.
Carcinogenesis
Mohs A,Kuttkat N,Otto T,Youssef SA,De Bruin A,Trautwein C
25-4801-82 was used in Flow cytometry/Cell sorting to suggest that signaling of Toll-like receptors through MyD88 in non-parenchymal liver cells is required for carcinogenesis during chronic liver injury.
Wed Apr 22 00:00:00 EDT 2020
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.
Cell
Rojas OL,Pröbstel AK,Porfilio EA,Wang AA,Charabati M,Sun T,Lee DSW,Galicia G,Ramaglia V,Ward LA,Leung LYT,Najafi G,Khaleghi K,Garcillán B,Li A,Besla R,Naouar I,Cao EY,Chiaranunt P,Burrows K,Robinson HG,Allanach JR,Yam J,Luck H,Campbell DJ,Allman D,Brooks DG,Tomura M,Baumann R,Zamvil SS,Bar-Or A,Horwitz MS,Winer DA,Mortha A,Mackay F,Prat A,Osborne LC,Robbins C,Baranzini SE,Gommerman JL
25-4801-82 was used in Flow Cytometry to show that IgA+ plasmablast and/or plasma cells mobilized from the gut play an role in suppressing neuroinflammation.
Thu Jan 24 00:00:00 EST 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
25-4801-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
25-4801 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 EDT 2019
Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages In Vitro and In Vivo.
Mediators of inflammation
de Carvalho Santuchi M,Dutra MF,Vago JP,Lima KM,Galvão I,de Souza-Neto FP,Morais E Silva M,Oliveira AC,de Oliveira FCB,Gonçalves R,Teixeira MM,Sousa LP,Dos Santos RAS,da Silva RF
25-4801 was used in Flow cytometry/Cell sorting to suggest that both Ang-(1-7) and alamandine, through their respective receptors Mas and MrgD, promote an anti-inflammatory reprogramming of M(LPS+IFN-γ)/M1 macrophages under inflammatory circumstances and potentiate the reprogramming induced by IL-4.
Mon Jul 22 00:00:00 EDT 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
25-4801 was used in Flow cytometry/Cell sorting to investigate the antitumor and immunomodulatory effects of CS2164.
Tue Oct 01 00:00:00 EDT 2019
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell stem cell
McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA
25-4801 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.
Thu Aug 01 00:00:00 EDT 2019
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.
Science advances
Lee YS,Riopel M,Cabrales P,Bandyopadhyay GK
25-4801-82 was used in Flow Cytometry to understand obesity-induced changes in liver oxygen homeostasis and find that liver HIF-1α expression was increased mainly by soluble factors released from obese adipocytes, leading to decreased incretin effects.
Mon Jul 01 00:00:00 EDT 2019
Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-traumatic Inflammation.
Frontiers in immunology
Agarwal S,Loder SJ,Cholok D,Li J,Bian G,Yalavarthi S,Li S,Carson WF,Hwang C,Marini S,Pagani C,Edwards N,Delano MJ,Standiford TJ,Knight JS,Kunkel SL,Mishina Y,Ward PA,Levi B
25-4801-82 was used in Flow Cytometry to evaluate the role of neutrophil extracellular traps in linking movement and inflammation.
Fri Oct 30 00:00:00 EDT 2020
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
25-4801 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Nature metabolism
Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM
25-4801-82 was used in Flow Cytometry to demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia.
Tue Jan 01 00:00:00 EST 2019
TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding.
Journal of translational medicine
Liu C,Li P,Li H,Wang S,Ding L,Wang H,Ye H,Jin Y,Hou J,Fang X,Shu Q
25-4801-82 was used in Flow cytometry/Cell sorting to report that level of trigger receptor expressed on myeloid cells 2 (TREM2) in adipose tissue is up-regulated in animal models of obesity.
Mon Sep 02 00:00:00 EDT 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
25-4801-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity.
Cell reports
Hurrell BP,Galle-Treger L,Jahani PS,Howard E,Helou DG,Banie H,Soroosh P,Akbari O
25-4801 was used in Flow cytometry/Cell sorting to investigate the role of TNF/TNFR2 axis in pulmonary ILC2s for possible use in treating ILC2-dependent asthma, in murine and human subjects.
Tue Dec 24 00:00:00 EST 2019
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy.
Cell reports
Hirukawa A,Singh S,Wang J,Rennhack JP,Swiatnicki M,Sanguin-Gendreau V,Zuo D,Daldoul K,Lavoie C,Park M,Andrechek ER,Westbrook TF,Harris LN,Varadan V,Smith HW,Muller WJ
25-4801-82 was used in Flow cytometry/Cell sorting to provide evidence that EZH2 inhibitors promote interferon-driven immune responses that enhance the efficacy of anti-ErbB2 mAbs, suggesting the potential clinical benefit of epigenomic reprogramming by H3K27me3 depletion in Trastuzumab-resistant disease.
Tue Oct 08 00:00:00 EDT 2019
Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Immunity
Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN
25-4801-82 was used in Flow cytometry/Cell sorting to study the role of transient receptor potential melastatin-like 7 in mediating the cytosolic Ca2+ elevations essential for lipopolysaccharide-induced macrophage activation.
Tue Jan 16 00:00:00 EST 2018
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Science translational medicine
Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL
25-4801 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.
Wed Mar 21 00:00:00 EDT 2018
p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.
PLoS biology
Matesanz N,Nikolic I,Leiva M,Pulgarín-Alfaro M,Santamans AM,Bernardo E,Mora A,Herrera-Melle L,Rodríguez E,Beiroa D,Caballero A,Martín-García E,Acín-Pérez R,Hernández-Cosido L,Leiva-Vega L,Torres JL,Centeno F,Nebreda AR,Enríquez JA,Nogueiras R,Marcos M,Sabio G
25-4801 was used in Flow cytometry/Cell sorting to study the effects of a lack of p38α in protecting against high-fat diet-induced obesity.
Sun Jul 01 00:00:00 EDT 2018
Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C).
Frontiers in immunology
Schmidt ST,Pedersen GK,Neustrup MA,Korsholm KS,Rades T,Andersen P,Foged C,Christensen D
25-4801 was used in Flow cytometry/Cell sorting to cAF24a is a promising adjuvant for induction of CTL responses upon s.c. and i.m. immunization.
Mon Jun 10 00:00:00 EDT 2019
Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.
Blood advances
Dangi A,Zhang L,Zhang X,Luo X
25-4801 was used in Flow cytometry/Cell sorting to provide a solid foundation for seeking effective therapies for promoting transplantation tolerance in settings of CMV infection.
Tue Mar 27 00:00:00 EDT 2018
Tumor-associated myeloid cells promote tumorigenesis of non-tumorigenic human and murine prostatic epithelial cell lines.
Cancer immunology, immunotherapy : CII
Sass SN,Ramsey KD,Egan SM,Wang J,Cortes Gomez E,Gollnick SO
25-4801 was used in Flow cytometry/Cell sorting to show that IL-1α inhibition leads to decreased angiogenesis within tumours, suggesting that IL-1α promotes prostate tumor progression.
Fri Jun 01 00:00:00 EDT 2018
Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1hi Monocytes.
Evidence-based complementary and alternative medicine : eCAM
Zhao XA,Chen G,Liu Y,Wu H,Chen J,Xiong Y,Tian C,Jia B,Wang G,Xia J,Chen Y,Wang J,Yan X,Zhang Z,Huang R,Wu C
25-4801 was used in Flow cytometry/Cell sorting to demonstrate that emodin can alleviate the degree of liver fibrosis by reducing infiltration of Gr1hi monocytes.
Thu Oct 01 00:00:00 EDT 2020
CCR2+ Monocyte-Derived Infiltrating Macrophages Are Required for Adverse Cardiac Remodeling During Pressure Overload.
JACC. Basic to translational science
Patel B,Bansal SS,Ismahil MA,Hamid T,Rokosh G,Mack M,Prabhu SD
25-4801 was used in Flow cytometry/Cell sorting to demonstrate that monocyte-derived C-C chemokine receptor 2 macrophages infiltrate the heart early during pressure overload in mice and blocking this response alleviates cardiac fibrosis..
Sun Apr 01 00:00:00 EDT 2018
Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.
Frontiers in immunology
Gubernatorova EO,Gorshkova EA,Namakanova OA,Zvartsev RV,Hidalgo J,Drutskaya MS,Tumanov AV,Nedospasov SA
25-4801 was used in Flow cytometry/Cell sorting to indicate that IL-6 plays a pathogenic role in the HDM-induced asthma model and that lung macrophages and dendritic cells are the predominant sources of pathogenic IL-6 but contribute differently to the disease.
Wed Oct 02 00:00:00 EDT 2019
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.
Cell
Ying W,Riopel M,Bandyopadhyay G,Dong Y,Birmingham A,Seo JB,Ofrecio JM,Wollam J,Hernandez-Carretero A,Fu W,Li P,Olefsky JM
25-4801 was used in Flow cytometry/Cell sorting to study the secretion of exosomes containing miRNA cargo by adipose tissue macrophages.
Thu Oct 05 00:00:00 EDT 2017
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Immunity
Minutti CM,Drube S,Blair N,Schwartz C,McCrae JC,McKenzie AN,Kamradt T,Mokry M,Coffer PJ,Sibilia M,Sijts AJ,Fallon PG,Maizels RM,Zaiss DM
25-4801 was used in Flow cytometry/Cell sorting to reveal a mechanism by which antigen presentation controls the innate effector function of Th2 cells at the site of inflammation.
Tue Oct 17 00:00:00 EDT 2017
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.
Gastroenterology
King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN
25-4801 was used in Flow cytometry/Cell sorting to investigate the role of sphingosine-1-phosphate in the response of hematopoietic stem cells to liver fibrosis in mice.
Sat Jul 01 00:00:00 EDT 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
25-4801 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.
The Journal of clinical investigation
Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM
25-4801 was used in Flow cytometry/Cell sorting to demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitising therapeutics.
Wed Mar 01 00:00:00 EST 2017
IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity.
Journal of immunology (Baltimore, Md. : 1950)
Braune J,Weyer U,Hobusch C,Mauer J,Brüning JC,Bechmann I,Gericke M
25-4801 was used in Flow cytometry/Cell sorting to study how IL-6 acts as a Th2 cytokine in obesity by stimulating M2 polarisation and local adipose tissue macrophages proliferation.
Sat Apr 01 00:00:00 EDT 2017
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice.
BMB reports
Kim OH,Kim H,Kang J,Yang D,Kang YH,Lee DH,Cheon GJ,Park SC,Oh BC
25-4801 was used in Flow cytometry/Cell sorting to identify age-dependent macrophage accumulation in the bone marrow, showing that ageing significantly increases the number of M1 macrophages and impairs polarisation of BMDMs.
Sun Jan 01 00:00:00 EST 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
25-4801 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
Microvasculature remodeling in the mouse lower gut during inflammaging.
Scientific reports
Jeong JH,Kim K,Lim D,Kim KH,Kim HS,Lee S,Song JH,Moon BG,Choy HE,Park SC
25-4801 was used in Flow cytometry/Cell sorting to show that microvessels in aging mouse intestine were progressively deprived of supportive structures, microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin, and became leaky.
Tue Jan 03 00:00:00 EST 2017
Isolation and Analysis of Stromal Vascular Cells from Visceral Adipose Tissue.
Bio-protocol
Vu J,Ying W
25-4801-82 was used in Flow Cytometry to show that these SVCs can be used to examine the population and activation status of immune cells by tracking their cell surface antigens, gene expression, and activation of specific signaling pathways.
Sun Aug 20 00:00:00 EDT 2017
CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
PloS one
Pierce AA,Duwaerts CC,Siao K,Mattis AN,Goodsell A,Baron JL,Maher JJ
25-4801 was used in Flow cytometry/Cell sorting to indicate that CD18 deficiency curbs methionine-choline-deficient mediated liver injury by limiting innate immune cell activation, without compromising intrahepatic cytokine activation.
Wed Oct 25 00:00:00 EDT 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
25-4801 was used in Flow cytometry/Cell sorting to demonstrate in colon and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-L1 expression on both cancer and immune cells in the tumour.
Mon Mar 27 00:00:00 EDT 2017
MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism.
Nature communications
Li X,Thome S,Ma X,Amrute-Nayak M,Finigan A,Kitt L,Masters L,James JR,Shi Y,Meng G,Mallat Z
25-4801 was used in Flow cytometry/Cell sorting to show that microtubule-affinity regulating kinase 4 binds to NLRP3 and drives it to the microtubule-organizing centre, enabling the formation of one large inflammasome speck complex within a single cell.
Wed Jun 28 00:00:00 EDT 2017
mTOR has distinct functions in generating versus sustaining humoral immunity.
The Journal of clinical investigation
Jones DD,Gaudette BT,Wilmore JR,Chernova I,Bortnick A,Weiss BM,Allman D
25-4801 was used in Flow cytometry/Cell sorting to conclude that mTOR signalling plays critical but diverse roles in early and late phases of antibody responses and plasma cell differentiation.
Tue Nov 01 00:00:00 EDT 2016
Adipose tissue adaptive response to trans-10,cis-12-conjugated linoleic acid engages alternatively activated M2 macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pini M,Touch S,Poirier H,Dalmas E,Niot I,Rouault C,Druart C,Delzenne N,Clément K,André S,Guerre-Millo M
25-4801 was used in Flow cytometry/Cell sorting to reveal a striking resilience of white adipose tissue after a short-term metabolic injury induced by t10,c12-CLA, which relies on alternatively activated M2 macrophage engagement.
Fri Jan 01 00:00:00 EST 2016
Enterococcus durans TN-3 Induces Regulatory T Cells and Suppresses the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis.
PloS one
Kanda T,Nishida A,Ohno M,Imaeda H,Shimada T,Inatomi O,Bamba S,Sugimoto M,Andoh A
25-4801 was used in Flow cytometry/Cell sorting to investigate the effects of E. durans TN-3 on the development of dextran sulfate sodium colitis.
Fri Jul 21 00:00:00 EDT 2017
CUG-binding protein 1 regulates HSC activation and liver fibrogenesis.
Nature communications
Wu X,Wu X,Ma Y,Shao F,Tan Y,Tan T,Gu L,Zhou Y,Sun B,Sun Y,Wu X,Xu Q
25480182 was used in flow cytometry to study the role of CUGBP1 in the profibrotic TGF-beta-dependent activation of hepatic stellate cells
Thu Nov 17 00:00:00 EST 2016
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.
eLife
Barreiro O,Cibrian D,Clemente C,Alvarez D,Moreno V,Valiente Í,Bernad A,Vestweber D,Arroyo AG,Martín P,von Andrian UH,Sánchez Madrid F
25-4801 was used in Flow cytometry/Cell sorting to describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules.
Wed Jun 15 00:00:00 EDT 2016
Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity.
Scientific reports
Chng SH,Kundu P,Dominguez-Brauer C,Teo WL,Kawajiri K,Fujii-Kuriyama Y,Mak TW,Pettersson S
25-4801 was used in Flow cytometry/Cell sorting to explore the contribution of the Aryl hydrocarbon Receptor signalling pathway to the regulation of innate immunity.
Tue Apr 12 00:00:00 EDT 2016
High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance.
PloS one
Pizzolla A,Oh DY,Luong S,Prickett SR,Henstridge DC,Febbraio MA,O'Hehir RE,Rolland JM,Hardy CL
25-4801 was used in Flow cytometry/Cell sorting to study the relationship between a high fat diet and allergic asthma using an induced-respiratory tolerance model in mice.
Wed Jul 26 00:00:00 EDT 2017
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
25-4801 was used in Flow cytometry/Cell sorting to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.
Oncotarget
Yong CS,John LB,Devaud C,Prince MH,Johnstone RW,Trapani JA,Darcy PK,Kershaw MH
25-4801 was used in Flow cytometry/Cell sorting to characterise the function of leukocytes from transgenic mice expressing a chimeric antigen receptor under the control of vav, and determine the ability of these mice to respond to ERB-expressing tumours.
Tue Jun 07 00:00:00 EDT 2016
Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection.
The Journal of clinical investigation
Tzelepis F,Verway M,Daoud J,Gillard J,Hassani-Ardakani K,Dunn J,Downey J,Gentile ME,Jaworska J,Sanchez AM,Nédélec Y,Vali H,Tabrizian M,Kristof AS,King IL,Barreiro LB,Divangahi M
25-4801 was used in Flow cytometry/Cell sorting to investigate the contribution of engulfment ligands to efferocytosis in vivo.
Sun Feb 01 00:00:00 EST 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
25-4801 was used in Flow cytometry/Cell sorting to investigate the role of Ackr1 in chronic inflammation, in particular in atherogenesis, using the apolipoprotein E-deficient mouse model.
Mon Jun 01 00:00:00 EDT 2015
IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis.
Nature communications
Nakamura R,Sene A,Santeford A,Gdoura A,Kubota S,Zapata N,Apte RS
25-4801 was used in Flow cytometry/Cell sorting to aid our understanding of the pathobiology of age-associated diseases and help guide targeted immunotherapy.
Tue Aug 11 00:00:00 EDT 2015
High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability.
PloS one
Johnson AM,Costanzo A,Gareau MG,Armando AM,Quehenberger O,Jameson JM,Olefsky JM
25-4801 was used in Flow cytometry/Cell sorting to show that high fat diet/obesity in mice does not cause monocyte/macrophage infiltration into the intestine or pro-inflammatory changes in gene expression.
Tue Apr 12 00:00:00 EDT 2016
Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.
PloS one
Yong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH
25-4801 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter.
Wed Jun 08 00:00:00 EDT 2016
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Nature medicine
Gibbs J,Ince L,Matthews L,Mei J,Bell T,Yang N,Saer B,Begley N,Poolman T,Pariollaud M,Farrow S,DeMayo F,Hussell T,Worthen GS,Ray D,Loudon A
25-4801 was used in Flow cytometry/Cell sorting to study the regulatory mechanism linking the circadian clock and glucocorticoid hormones, to control time-of-day variation and the magnitude of pulmonary inflammation.
Fri Aug 01 00:00:00 EDT 2014
Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice.
Gastroenterology
Xiao B,Laroui H,Viennois E,Ayyadurai S,Charania MA,Zhang Y,Zhang Z,Baker MT,Zhang B,Gewirtz AT,Merlin D
25-4801 was used in Flow cytometry/Cell sorting to develop an orally delivered hydrogel that releases nanoparticles with CD98 antibodies and siRNA, and test its ability to reduce levels of CD98 in the colons of mice with colitis.
Thu May 01 00:00:00 EDT 2014
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.
Nature cell biology
Lu H,Clauser KR,Tam WL,Fröse J,Ye X,Eaton EN,Reinhardt F,Donnenberg VS,Bhargava R,Carr SA,Weinberg RA
25-4801 was used in Flow cytometry/Cell sorting to investigate the interactions between cancer stem cells and their surrounding microenvironment.
Sat Nov 01 00:00:00 EDT 2014
VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease.
The Journal of clinical investigation
D'Alessio S,Correale C,Tacconi C,Gandelli A,Pietrogrande G,Vetrano S,Genua M,Arena V,Spinelli A,Peyrin-Biroulet L,Fiocchi C,Danese S
25-4801 was used in Flow cytometry/Cell sorting to provide proof of concept that it may be possible to treat chronic gastrointestinal inflammatory disorders by stimulating lymphatic vessel function and the adaptive immune response.
Mon Sep 01 00:00:00 EDT 2014
Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.
Molecular therapy : the journal of the American Society of Gene Therapy
Devaud C,Westwood JA,John LB,Flynn JK,Paquet-Fifield S,Duong CP,Yong CS,Pegram HJ,Stacker SA,Achen MG,Stewart TJ,Snyder LA,Teng MW,Smyth MJ,Darcy PK,Kershaw MH
25-4801 was used in Flow cytometry/Cell sorting to explore the relationship between tumour microenvironments and efficacy of immunotherapy.
Wed Jan 01 00:00:00 EST 2014
Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.
Molecular therapy : the journal of the American Society of Gene Therapy
Laroui H,Geem D,Xiao B,Viennois E,Rakhya P,Denning T,Merlin D
25-4801 was used in Flow cytometry/Cell sorting to show that CD98 was effectively down-regulated in the intestinal epithelial cells and intestinal macrophages of treated mice.
Wed Jan 01 00:00:00 EST 2014
CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.
Mucosal immunology
Rossini V,Zhurina D,Radulovic K,Manta C,Walther P,Riedel CU,Niess JH
25-4801 was used in Flow cytometry/Cell sorting to study immune cell communication during the development of transfer colitis.
Thu May 01 00:00:00 EDT 2014
Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice.
Journal of immunology (Baltimore, Md. : 1950)
Lam RS,O'Brien-Simpson NM,Lenzo JC,Holden JA,Brammar GC,Walsh KA,McNaughtan JE,Rowler DK,Van Rooijen N,Reynolds EC
25-4801 was used in Flow cytometry/Cell sorting to define the role of the macrophage in the immunopathology of periodontitis.
Mon Sep 01 00:00:00 EDT 2014
The use of anchored agonists of phagocytic receptors for cancer immunotherapy: B16-F10 murine melanoma model.
PloS one
Janotová T,Jalovecká M,Auerová M,Švecová I,Bruzlová P,Maierová V,Kumžáková Z,Cunátová Š,Vlčková Z,Caisová V,Rozsypalová P,Lukáčová K,Vácová N,Wachtlová M,Salát J,Lieskovská J,Kopecký J,Ženka J
25-4801 was used in Flow cytometry/Cell sorting to assess the anti-tumour potential of fusing phagocytic receptor agonists to cancer cells.
Thu Sep 18 00:00:00 EDT 2014
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
25-4801 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 EST 2015
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
The Journal of experimental medicine
Molofsky AB,Nussbaum JC,Liang HE,Van Dyken SJ,Cheng LE,Mohapatra A,Chawla A,Locksley RM
25-4801 was used in Flow cytometry/Cell sorting to study how ILC2s are resident in visceral adipose tissue and promote eosinophils and alternatively activated macrophages, implicated in metabolic homeostasis.
Mon Mar 11 00:00:00 EDT 2013
Glutathione reductase is essential for host defense against bacterial infection.
Free radical biology & medicine
Yan J,Ralston MM,Meng X,Bongiovanni KD,Jones AL,Benndorf R,Nelin LD,Joshua Frazier W,Rogers LK,Smith CV,Liu Y
25-4801 was used in Flow cytometry/Cell sorting to characterise the effects of glutathione reductase deficiency on the innate immune response to a Gram-positive bacterium and lipopolysaccharide.
Thu Aug 01 00:00:00 EDT 2013
Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age.
Journal of immunology (Baltimore, Md. : 1950)
Brubaker AL,Rendon JL,Ramirez L,Choudhry MA,Kovacs EJ
25-4801 was used in Flow cytometry/Cell sorting to deduce the contribution of reduced neutrophil chemotaxis and infiltration to the speed of wound infection healing.
Fri Feb 15 00:00:00 EST 2013
Differential uptake of nanoparticles and microparticles by pulmonary APC subsets induces discrete immunological imprints.
Journal of immunology (Baltimore, Md. : 1950)
Hardy CL,Lemasurier JS,Mohamud R,Yao J,Xiang SD,Rolland JM,O'Hehir RE,Plebanski M
25-4801 was used in Flow cytometry/Cell sorting to study the uptake of different sized particles by lung macrophages and dendritic cells.
Fri Nov 15 00:00:00 EST 2013
Inflammatory monocytes are critical for induction of a polysaccharide-specific antibody response to an intact bacterium.
Journal of immunology (Baltimore, Md. : 1950)
Chen Q,Snapper CM
25-4801 was used in Flow cytometry/Cell sorting to investigate the impact of inflammatory monocytes on humoural immune responses to extracellular bacteria.
Fri Feb 01 00:00:00 EST 2013
Candida albicans stimulates in vivo differentiation of haematopoietic stem and progenitor cells towards macrophages by a TLR2-dependent signalling.
Cellular microbiology
Megías J,Maneu V,Salvador P,Gozalbo D,Gil ML
25-4801 was used in Flow cytometry/Cell sorting to report that haematopoietic stem and progenitor cells sense Candida albicans in vivo and subsequently are directed to produce macrophages by a Toll like receptor 2-dependent signalling.
Mon Jul 01 00:00:00 EDT 2013
G-CSF enhances resolution of Staphylococcus aureus wound infection in an age-dependent manner.
Shock (Augusta, Ga.)
Brubaker AL,Kovacs EJ
25-4801 was used in Flow cytometry/Cell sorting to demonstrate that G-CSF enhances bacterial clearance and wound closure in an age-dependent manner.
Tue Oct 01 00:00:00 EDT 2013
Two-photon microscopy imaging of thy1GFP-M transgenic mice: a novel animal model to investigate brain dendritic cell subsets in vivo.
PloS one
Laperchia C,Allegra Mascaro AL,Sacconi L,Andrioli A,Mattè A,De Franceschi L,Grassi-Zucconi G,Bentivoglio M,Buffelli M,Pavone FS
25-4801 was used in Flow cytometry/Cell sorting to employ a transgenic mouse model to study professional antigen-presenting cells in the brain.
Mon Jul 29 00:00:00 EDT 2013
Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.
PLoS pathogens
Lionakis MS,Fischer BG,Lim JK,Swamydas M,Wan W,Richard Lee CC,Cohen JI,Scheinberg P,Gao JL,Murphy PM
25-4801 was used in Flow cytometry/Cell sorting to show that mice lacking the chemokine receptor Ccr1 have improved renal function and survival without affecting the tissue fungal burden.
Mon Dec 17 00:00:00 EST 2012
Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.
Journal of immunology (Baltimore, Md. : 1950)
Yan J,Meng X,Wancket LM,Lintner K,Nelin LD,Chen B,Francis KP,Smith CV,Rogers LK,Liu Y
25-4801 was used in Flow cytometry/Cell sorting to study how glutathione reductase mediated redox regulation is crucial for bacterial clearance during host defence against bacterial challenge.
Thu Mar 01 00:00:00 EST 2012
Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion.
Infection and immunity
Smith KA,Harcus Y,Garbi N,Hämmerling GJ,MacDonald AS,Maizels RM
25-4801 was used in Flow cytometry/Cell sorting to investigate the type 2 response to intestinal nematode parasites, showing that it is induced redundantly and acts autonomously following CD11c(+) cell depletion.
Mon Oct 01 00:00:00 EDT 2012
The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfection.
Infection and immunity
Riley MM,Zurenski MA,Frazer LC,O'Connell CM,Andrews CW,Mintus M,Darville T
25-4801 was used in Flow cytometry/Cell sorting to indicate that exposure to a live vaccine with virulent chlamydiae promotes anamnestic antibody and T cell responses that protect the oviduct from pathology.
Fri Jun 01 00:00:00 EDT 2012
A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.
Chemistry & biology
Verdoes M,Edgington LE,Scheeren FA,Leyva M,Blum G,Weiskopf K,Bachmann MH,Ellman JA,Bogyo M
25-4801 was used in Flow cytometry/Cell sorting to study how BMV083 may be a valuable in vivo reporter for tumor-associated macrophages.
Fri May 25 00:00:00 EDT 2012
A Francisella tularensis live vaccine strain that improves stimulation of antigen-presenting cells does not enhance vaccine efficacy.
PloS one
Schmitt DM,O'Dee DM,Horzempa J,Carlson PE,Russo BC,Bales JM,Brown MJ,Nau GJ
25-4801 was used in Flow cytometry/Cell sorting to examine whether the interaction of genetically modified Francisella tularensis live vaccine strains with human antigen-presenting cells correlates with vaccine effectiveness.
Mon Jun 18 00:00:00 EDT 2012
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.
Blood
Choi H,Lee RH,Bazhanov N,Oh JY,Prockop DJ
25-4801 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which hMSCs repair tissues and modulate immune systems, showing that secretion of TSG-6 attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling.
Thu Jul 14 00:00:00 EDT 2011
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
The Journal of clinical investigation
Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL
25-4801 was used in Flow cytometry/Cell sorting to investigate the relative contributions of different APC populations in IBD, showing that CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses.
Thu Dec 01 00:00:00 EST 2011
Organ-specific innate immune responses in a mouse model of invasive candidiasis.
Journal of innate immunity
Lionakis MS,Lim JK,Lee CC,Murphy PM
25-4801 was used in Flow cytometry/Cell sorting to provide the first detailed analysis of leukocyte subsets accumulating in different target organs during invasive candidiasis.
Fri Jun 17 00:00:00 EDT 2011
Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis.
The American journal of pathology
Piehler D,Stenzel W,Grahnert A,Held J,Richter L,Köhler G,Richter T,Eschke M,Alber G,Müller U
25-4801 was used in Flow cytometry/Cell sorting to investigate the time course of IL-4 production and its innate cellular source in mice infected intranasally with Cryptococcus neoformans.
Mon Aug 01 00:00:00 EDT 2011
Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses.
Journal of immunology (Baltimore, Md. : 1950)
Brown KL,Poon GF,Birkenhead D,Pena OM,Falsafi R,Dahlgren C,Karlsson A,Bylund J,Hancock RE,Johnson P
25-4801 was used in Flow cytometry/Cell sorting to demonstrate the selective ability of LL-37 to decrease M1-BMDM, M2-BMDM, and tissue macrophage production of the proinflammatory cytokine TNF-α in response to LPS in mice.
Sun May 01 00:00:00 EDT 2011
Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.
Journal of immunology (Baltimore, Md. : 1950)
Denning TL,Norris BA,Medina-Contreras O,Manicassamy S,Geem D,Madan R,Karp CL,Pulendran B
25-4801 was used in Flow cytometry/Cell sorting to systematically evaluate the phenotype, function and regional localisation of intestinal APCs.
Fri Jul 15 00:00:00 EDT 2011
An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes.
Journal of immunological methods
Brubaker AL,Schneider DF,Palmer JL,Faunce DE,Kovacs EJ
25-4801 was used in Flow cytometry/Cell sorting to develop a method for preparing wound cell suspensions for further study.
Fri Oct 28 00:00:00 EDT 2011
Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.
PloS one
Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML
25-4801 was used in Flow cytometry/Cell sorting to investigate how C. albicans invasive infection with a low virulence strain results in a rapid expansion of HSPCs.
Tue Feb 28 00:00:00 EST 2012
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
The Journal of clinical investigation
Tsou CL,Peters W,Si Y,Slaymaker S,Aslanian AM,Weisberg SP,Mack M,Charo IF
25-4801 was used in Flow cytometry/Cell sorting to report that CC chemokine receptor 2 is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2(-/-) mice.
Sun Apr 01 00:00:00 EDT 2007
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology
Geutskens SB,Otonkoski T,Pulkkinen MA,Drexhage HA,Leenen PJ
Sat Oct 01 00:00:00 EDT 2005
