Product References
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations.
Oncogene
Pawlikowska P,Delestré L,Gregoricchio S,Oppezzo A,Esposito M,Diop MB,Rosselli F,Guillouf C
25-0452-82 was used in Flow cytometry/Cell sorting to indicate that loss of the FANC pathway, known to control genetic instability, fosters the expansion of leukaemic cells carrying oncogenic mutations rather than mutation formation.
Fri Sep 01 00:00:00 EDT 2023
CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.
Communications biology
Rege SV,Teichert A,Masumi J,Dhande OS,Harish R,Higgins BW,Lopez Y,Akrapongpisak L,Hackbart H,Caryotakis S,Leone DP,Szoke B,Hannestad J,Nikolich K,Braithwaite SP,Minami SS
25-0452-82 was used in Flow cytometry/Cell sorting to indicate the broad therapeutic potential of CCR3 inhibition in a spectrum of neuroinflammatory diseases of aging.
Sat Mar 18 00:00:00 EDT 2023
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
JCI insight
Zhong L,Yao L,Holdreith N,Yu W,Gui T,Miao Z,Elkaim Y,Li M,Gong Y,Pacifici M,Maity A,Busch TM,Joeng KS,Cengel K,Seale P,Tong W,Qin L
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Aug 19 00:00:00 EDT 2022
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.
Nature communications
Schick M,Zhang L,Maurer S,Maurer HC,Isaakaidis K,Schneider L,Patra U,Schunck K,Rohleder E,Hofstetter J,Baluapuri A,Scherger AK,Slotta-Huspenina J,Hettler F,Weber J,Engleitner T,Maresch R,Slawska J,Lewis R,Istvanffy R,Habringer S,Steiger K,Baiker A,Oostendorp RAJ,Miething C,Lenhof HP,Bassermann F,Chapuy B,Wirth M,Wolf E,Rad R,Müller S,Keller U
25-0452-82 was used in Flow Cytometry to identify the SUMO isopeptidase SENP6 as a tumor suppressor that links unrestricted SUMOylation to tumor development and progression.
Wed Jan 12 00:00:00 EST 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Mar 08 00:00:00 EST 2022
Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.
Molecular oncology
Ma W,Wan Y,Zhang J,Yao J,Wang Y,Lu J,Liu H,Huang X,Zhang X,Zhou H,He Y,Wu D,Wang J,Zhao Y
25-0452-82 was used in Flow cytometry/Cell sorting to suggest that targeting the GAS2/CXCR4 axis is a potential therapeutic strategy for T-ALL.
Sat Oct 01 00:00:00 EDT 2022
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity.
Cellular & molecular immunology
Huang X,Hao S,Liu J,Huang Y,Liu M,Xiao C,Wang Y,Pei S,Yu T,Xu J,Wang H,Dai D,Su X,Xiao Y
25-0452-82 was used in Flow Cytometry to elucidate the molecular mechanisms regulating T follicular helper cells.
Thu Apr 01 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice.
European journal of immunology
Monzón-Casanova E,Bates KJ,Smith CWJ,Turner M
25-0452-82 was used in Flow Cytometry to show that the polypyrimidine tract binding proteins (PTBP) PTBP1 and PTBP3 bind to a large and overlapping set of transcripts in B cells.
Wed Sep 01 00:00:00 EDT 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Nov 10 00:00:00 EST 2021
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia.
Infection and immunity
Sen-Kilic E,Blackwood CB,Huckaby AB,Horspool AM,Weaver KL,Malkowski AC,Witt WT,Bevere JR,Damron FH,Barbier M
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Jan 19 00:00:00 EST 2021
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem cell research
Sudo K,Yamazaki S,Wilkinson AC,Nakauchi H,Nakamura Y
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
eLife
Hill DL,Whyte CE,Innocentin S,Lee JL,Dooley J,Wang J,James EA,Lee JC,Kwok WW,Zand MS,Liston A,Carr EJ,Linterman MA
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Nov 02 00:00:00 EDT 2021
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
JCI insight
Wilson CS,Stocks BT,Hoopes EM,Rhoads JP,McNew KL,Major AS,Moore DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Oct 08 00:00:00 EDT 2021
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Nature communications
Shang M,Yang H,Yang R,Chen T,Fu Y,Li Y,Fang X,Zhang K,Zhang J,Li H,Cao X,Gu J,Xiao J,Zhang Q,Liu X,Yu Q,Wang T
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.
The Journal of biological chemistry
Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
25-0452-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae.
iScience
Macbeth JC,Liu R,Alavi S,Hsiao A
25-0452-82 was used in Flow cytometry/Cell sorting to suggest that gut microbiome composition at time of infection or vaccination may be pivotal for providing robust mucosal immunity, and suggest a target for improved prophylactic and therapeutic strategies for cholera.
Fri Dec 17 00:00:00 EST 2021
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
25-0452 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Immunity
Lederer K,Castaño D,Gómez Atria D,Oguin TH,Wang S,Manzoni TB,Muramatsu H,Hogan MJ,Amanat F,Cherubin P,Lundgreen KA,Tam YK,Fan SHY,Eisenlohr LC,Maillard I,Weissman D,Bates P,Krammer F,Sempowski GD,Pardi N,Locci M
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Tumor Cell-Derived Angiopoietin-2 Promotes Metastasis in Melanoma.
Cancer research
Abdul Pari AA,Singhal M,Hübers C,Mogler C,Schieb B,Gampp A,Gengenbacher N,Reynolds LE,Terhardt D,Géraud C,Utikal J,Thomas M,Goerdt S,Hodivala-Dilke KM,Augustin HG,Felcht M
25-0452-82 was used in Flow Cytometry to reveal that tumor cells can be a source of ANGPT2 in the tumor microenvironment and that tumor cell-derived ANGPT2 augments metastatic colonization by protecting tumor cells from oxidative stress.
Mon Jun 15 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Frontiers in immunology
Larson SR,Bortell N,Illies A,Crisler WJ,Matsuda JL,Lenz LL
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Jun 14 00:00:00 EDT 2021
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Nature communications
Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF
25-0452 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.
Fri Nov 13 00:00:00 EST 2020
Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.
Cell reports
Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T
25-0452 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.
Tue Jun 16 00:00:00 EDT 2020
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Cell reports
Castro-Dopico T,Fleming A,Dennison TW,Ferdinand JR,Harcourt K,Stewart BJ,Cader Z,Tuong ZK,Jing C,Lok LSC,Mathews RJ,Portet A,Kaser A,Clare S,Clatworthy MR
25-0452 was used in Flow cytometry/Cell sorting to identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.
Tue Jul 07 00:00:00 EDT 2020
Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.
iScience
Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T
25-0452 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.
Fri Jul 24 00:00:00 EDT 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
25-0452-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
25-0452 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
Nature immunology
Hatzi K,Geng H,Doane AS,Meydan C,LaRiviere R,Cardenas M,Duy C,Shen H,Vidal MNC,Baslan T,Mohammad HP,Kruger RG,Shaknovich R,Haberman AM,Inghirami G,Lowe SW,Melnick AM
25-0452 was used in Flow cytometry/Cell sorting to demonstrate that LSD1 modulates enhancer function by forming repression complexes with BCL6 during the humoral immune response.
Tue Jan 01 00:00:00 EST 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue May 14 00:00:00 EDT 2019
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.
Cell reports
Adane B,Ye H,Khan N,Pei S,Minhajuddin M,Stevens BM,Jones CL,D'Alessandro A,Reisz JA,Zaberezhnyy V,Gasparetto M,Ho TC,Kelly KK,Myers JR,Ashton JM,Siegenthaler J,Kume T,Campbell EL,Pollyea DA,Becker MW,Jordan CT
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Apr 02 00:00:00 EDT 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Immunity
Li X,Gadzinsky A,Gong L,Tong H,Calderon V,Li Y,Kitamura D,Klein U,Langdon WY,Hou F,Zou YR,Gu H
25-0452-82 was used in Flow Cytometry to show that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells results in the early exit of high-affinity antigen-specific B cells from the GC reaction and thus impaired clonal expansion.
Tue Mar 20 00:00:00 EDT 2018
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.
Immunity
Evrard M,Kwok IWH,Chong SZ,Teng KWW,Becht E,Chen J,Sieow JL,Penny HL,Ching GC,Devi S,Adrover JM,Li JLY,Liong KH,Tan L,Poon Z,Foo S,Chua JW,Su IH,Balabanian K,Bachelerie F,Biswas SK,Larbi A,Hwang WYK,Madan V,Koeffler HP,Wong SC,Newell EW,Hidalgo A,Ginhoux F,Ng LG
25-0452 was used in Flow cytometry/Cell sorting to identifies specialised bone marrow granulocytic populations that ensure supply under homeostasis and stress responses.
Tue Feb 20 00:00:00 EST 2018
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
25-0452-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Mar 15 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis.
International journal of molecular medicine
Tsunoda T,Doi K,Ishikura S,Luo H,Nishi K,Matsuzaki H,Koyanagi M,Tanaka Y,Okamura T,Shirasawa S
25-0452-82 was used in Flow Cytometry to identify the expression and function of Zfat using ZsGreen signalling in the ZfatZsG/+ reporter mouse model.
Thu Nov 01 00:00:00 EDT 2018
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Experimental and therapeutic medicine
Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.
Frontiers in immunology
Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Sep 26 00:00:00 EDT 2019
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
25-0452 was used in Flow cytometry/Cell sorting to show that the deubiquitinase POH1 negatively regulates the immune response triggered by inflammasome activation.
Fri Oct 12 00:00:00 EDT 2018
TLR9 Signaling Suppresses the Canonical Plasma Cell Differentiation Program in Follicular B Cells.
Frontiers in immunology
Baptista BJA,Granato A,Canto FB,Montalvão F,Tostes L,de Matos Guedes HL,Coutinho A,Bellio M,Vale AM,Nobrega A
25-0452 was used in Flow cytometry/Cell sorting to identify unexpected, opposing roles for Toll-like receptor4 and TLR9 in the control of plasma B cell differentiation programmes.
Mon Sep 30 00:00:00 EDT 2019
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
25-0452 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.
Mon Jul 16 00:00:00 EDT 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
25-0452 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.
Tue Jun 19 00:00:00 EDT 2018
Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.
Journal of thrombosis and haemostasis : JTH
Lai JD,Cartier D,Hartholt RB,Swystun LL,van Velzen AS,den Haan JMM,Hough C,Voorberg J,Lillicrap D
25-0452 was used in Flow cytometry/Cell sorting to assess cellular interactions and expression profiles in hemophilia A mice.
Thu Mar 01 00:00:00 EST 2018
High-affinity IgM+ memory B cells are defective in differentiation into IgM antibody-secreting cells by re-stimulation with a T cell-dependent antigen.
Scientific reports
Tashiro Y,Murakami A,Hara Y,Shimizu T,Kubo M,Goitsuka R,Kishimoto H,Azuma T
25-0452 was used in Flow cytometry/Cell sorting to demonstrate that only non-germinal centre-dependent IgM+ memomry B cells have terminal differential potential to become plasma cell during recall immune response.
Fri Sep 28 00:00:00 EDT 2018
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.
Cell
Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A
25-0452 was used in Flow cytometry/Cell sorting to highlight the impact of dietary vitamin A on the regulation of cell-cycle-mediated stem cell plasticity.
Thu May 18 00:00:00 EDT 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
25-0452 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.
Nature immunology
Minguet S,Kläsener K,Schaffer AM,Fiala GJ,Osteso-Ibánez T,Raute K,Navarro-Lérida I,Hartl FA,Seidl M,Reth M,Del Pozo MA
25-0452 was used in Flow cytometry/Cell sorting to study the role of Caveolin-1 in controlling the distribution of nanoclusters of isotype-specific B cell antigen receptors on the surface of B cells.
Sun Oct 01 00:00:00 EDT 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis.
Frontiers in neurology
Peake K,Manning J,Lewis CA,Tran K,Rossi F,Krieger C
25-0452 was used in Flow cytometry/Cell sorting to indicate that establishment of high levels of blood and BM chimerism alone is not sufficient to induce BMDC accumulation within the CNS.
Thu Oct 01 00:00:00 EDT 2020
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
25-0452 was used in Flow cytometry/Cell sorting to show EZH2 mediates germinal centre formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.
Thu Oct 12 00:00:00 EDT 2017
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nature communications
Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
JCI insight
Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
PloS one
Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
25-0452 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
IFNγ is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection.
Infection and immunity
Naglak EK,Morrison SG,Morrison RP
25-0452 was used in Flow cytometry/Cell sorting to examine the importance of interferon-gamma in antibody-mediated protection against chlamydia infection.
Tue Nov 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
25-0452 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis.
Cell death & disease
Famili F,Perez LG,Naber BA,Noordermeer JN,Fradkin LG,Staal FJ
25-0452 was used in Flow cytometry/Cell sorting to investigate the role of the non-canonical Wnt receptor Ryk in haematopoiesis and lymphoid development.
Thu Nov 24 00:00:00 EST 2016
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
The Journal of experimental medicine
Fiala GJ,Janowska I,Prutek F,Hobeika E,Satapathy A,Sprenger A,Plum T,Seidl M,Dengjel J,Reth M,Cesca F,Brummer T,Minguet S,Schamel WW
25-0452 was used in Flow cytometry/Cell sorting to study Kidins220/ARMS binding to the B cell antigen receptor and its regulation of B cell development and activation.
Mon Sep 21 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
Annals of neurology
Lehmann-Horn K,Sagan SA,Bernard CC,Sobel RA,Zamvil SS
25-0452 was used in Flow cytometry/Cell sorting to report that the selective inhibition of VLA-4 expression on B cells impedes CNS accumulation of B cells, and recruitment of Th17 cells and macrophages.
Fri May 01 00:00:00 EDT 2015
A CB2-Selective Cannabinoid Suppresses T-Cell Activities and Increases Tregs and IL-10.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Robinson RH,Meissler JJ,Fan X,Yu D,Adler MW,Eisenstein TK
25-0452 was used in Flow cytometry/Cell sorting to support the potential of CB2-selective agonists as useful therapeutic agents to prolong graft survival in transplant patients.
Mon Jun 01 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
25-0452 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hüttl S,Kläsener K,Schweizer M,Schneppenheim J,Oberg HH,Kabelitz D,Reth M,Saftig P,Schröder B
25-0452 was used in Flow cytometry/Cell sorting to demonstrate that tonic as well as BCR-induced activation of the PI3K/Akt pathway is massively compromised in SPPL2a(-/-) B cells.
Sat Aug 15 00:00:00 EDT 2015
Endothelial Gata5 transcription factor regulates blood pressure.
Nature communications
Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Nov 30 00:00:00 EST 2015
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.
Nature communications
Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Jun 24 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
25-0452 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines.
Scientific reports
Szeto GL,Van Egeren D,Worku H,Sharei A,Alejandro B,Park C,Frew K,Brefo M,Mao S,Heimann M,Langer R,Jensen K,Irvine DJ
25-0452 was used in Flow cytometry/Cell sorting to demonstrate proof-of-concept for mechano-poration as an enabling technology for loading B-cells with antigens to prime specific CD8(+)T-cells.
Fri May 22 00:00:00 EDT 2015
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.
The Journal of clinical investigation
Cho J,Yusuf R,Kook S,Attar E,Lee D,Park B,Cheng T,Scadden DT,Lee BC
25-0452 was used in Flow cytometry/Cell sorting to study the role of P2Y14 receptors on stem/progenitor cells in modifying cell senescence and cell death in response to tissue stress.
Tue Jul 01 00:00:00 EDT 2014
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Journal of immunology (Baltimore, Md. : 1950)
Park KS,Bayles I,Szlachta-McGinn A,Paul J,Boiko J,Santos P,Liu J,Wang Z,Borghesi L,Milcarek C
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Sat Nov 01 00:00:00 EDT 2014
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Journal of immunology (Baltimore, Md. : 1950)
Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Apr 01 00:00:00 EDT 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
25-0452 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.
Tue Apr 15 00:00:00 EDT 2014
IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.
Journal of immunology (Baltimore, Md. : 1950)
Granato A,Hayashi EA,Baptista BJ,Bellio M,Nobrega A
Sun Jun 15 00:00:00 EDT 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
25-0452 was used in Flow cytometry/Cell sorting to investigate the importance of GM-CSF in the development of severe interstitial lung disease.
Tue Jul 15 00:00:00 EDT 2014
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
White CA,Pone EJ,Lam T,Tat C,Hayama KL,Li G,Zan H,Casali P
25-0452 was used in Flow cytometry/Cell sorting to study the epigenetic mechanisms which modulate expression of proteins involved in B cell differentiation and autoimmunity..
Mon Dec 15 00:00:00 EST 2014
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.
Journal of immunology (Baltimore, Md. : 1950)
White CA,Pone EJ,Lam T,Tat C,Hayama KL,Li G,Zan H,Casali P
25-0452 was used in Flow cytometry/Cell sorting to study the epigenetic mechanisms which modulate expression of proteins involved in B cell differentiation and autoimmunity..
Mon Dec 15 00:00:00 EST 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
25-0452 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 EDT 2014
Rhof promotes murine marginal zone B cell development.
Nagoya journal of medical science
Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Aug 01 00:00:00 EDT 2014
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
PloS one
Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.
PloS one
Vanoaica L,Richman L,Jaworski M,Darshan D,Luther SA,Kühn LC
25-0452 was used in Flow cytometry/Cell sorting to investigate the effect of ferritin H deletion on lymphocytes, showing that it reduces B and T lymphocyte populations.
Tue Jan 13 00:00:00 EST 2015
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
25-0452 was used in Flow cytometry/Cell sorting to investigate the precise role and expression pattern of brain-expressed X-linked genes in endocrine and tissue stem/progenitor cells in mice.
Fri Oct 24 00:00:00 EDT 2014
Dominant lethal pathologies in male mice engineered to contain an X-linked DUX4 transgene.
Cell reports
Dandapat A,Bosnakovski D,Hartweck LM,Arpke RW,Baltgalvis KA,Vang D,Baik J,Darabi R,Perlingeiro RC,Hamra FK,Gupta K,Lowe DA,Kyba M
25-0452 was used in Flow cytometry/Cell sorting to demonstrate a murine model with potential use for testing anti-DUX4 therapies in facioscapulohumeral muscular dystrophy.
Thu Sep 11 00:00:00 EDT 2014
NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.
PloS one
Reed SM,Hagen J,Muniz VP,Rosean TR,Borcherding N,Sciegienka S,Goeken JA,Naumann PW,Zhang W,Tompkins VS,Janz S,Meyerholz DK,Quelle DE
25-0452 was used in Flow cytometry/Cell sorting to investigate the predicted role of the nuclear interactor of ARF and Mdm2 as a tumour suppressor.
Fri Jan 15 00:00:00 EST 2016
Discriminating cellular heterogeneity using microwell-based RNA cytometry.
Nature communications
Dimov IK,Lu R,Lee EP,Seita J,Sahoo D,Park SM,Weissman IL,Lee LP
25-0452 was used in Flow cytometry/Cell sorting to develop a two-stage system to determine cellular heterogeneity.
Tue Mar 25 00:00:00 EDT 2014
Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9.
Molecular therapy. Methods & clinical development
Stitelman DH,Brazelton T,Bora A,Traas J,Merianos D,Limberis M,Davey M,Flake AW
25-0452 was used in Flow cytometry/Cell sorting to study the efficiency of gene transfer via adeno-associated virus vector serotype 2/9 to muscle satellite cells at different developmental stages, to show that higher efficiency of transfer occurs at E16 when satellite cells (muscle stem cells) migrate.
Wed May 27 00:00:00 EDT 2015
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.
Nature immunology
Bermejo DA,Jackson SW,Gorosito-Serran M,Acosta-Rodriguez EV,Amezcua-Vesely MC,Sather BD,Singh AK,Khim S,Mucci J,Liggitt D,Campetella O,Oukka M,Gruppi A,Rawlings DJ
25-0452 was used in Flow cytometry/Cell sorting to study how the generation of IL-17 B cells may be a feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity.
Wed May 01 00:00:00 EDT 2013
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.
The Journal of clinical investigation
Kook S,Cho J,Lee SB,Lee BC
25-0452 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism governing the migration of haematopoietic stem progenitor cells under stress.
Thu Aug 01 00:00:00 EDT 2013
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
25-0452 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
25-0452 was used in Flow cytometry/Cell sorting to understand the function of autophagosome degradation in survival of activated T cells, by comparison of the effects of blocking autophagy at an early (atg5-/-) or late (rab7-/-) stage on T cell biology in mice.
Mon Jul 01 00:00:00 EDT 2013
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.
The Journal of investigative dermatology
Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB
25-0452 was used in Flow cytometry/Cell sorting to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.
Tue Jan 01 00:00:00 EST 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
25-0452 was used in Flow cytometry/Cell sorting to demonstrate that increased expression of Prdm14 drives development of T-Cell acute lymphoblastic leukemia in mice.
Fri Nov 01 00:00:00 EDT 2013
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu Jun 13 00:00:00 EDT 2013
Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.
PloS one
Wu X,Satpathy AT,Kc W,Liu P,Murphy TL,Murphy KM
25-0452 was used in Flow cytometry/Cell sorting to investigate the role of Bcl11a in the development of dendritic cells, showing that it controls Flt3 expression in early hematopoietic progenitors and is required for pDC development.
Fri Jan 10 00:00:00 EST 2014
Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
PloS one
Tornack J,Seiler K,Grützkau A,Grün JR,Onodera M,Melchers F,Tsuneto M
25-0452 was used in Flow cytometry/Cell sorting to suggest that Tal-1 expression is needed to express Runx1 in the mesoderm.
Thu Aug 21 00:00:00 EDT 2014
Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.
PloS one
Billich A,Baumruker T,Beerli C,Bigaud M,Bruns C,Calzascia T,Isken A,Kinzel B,Loetscher E,Metzler B,Mueller M,Nuesslein-Hildesheim B,Kleylein-Sohn B
25-0452 was used in Flow cytometry/Cell sorting to investigate the involvement of Sgpl1 in models of disease, showing that partial deficiency confers protection in EAE.
Tue Sep 17 00:00:00 EDT 2013
The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.
Blood
Seillet C,Laffont S,Trémollières F,Rouquié N,Ribot C,Arnal JF,Douin-Echinard V,Gourdy P,Guéry JC
25-0452 was used in Flow cytometry/Cell sorting to uncover a role for estrogens in regulating the innate functions of plasmacytoid dendritic cells.
Thu Jan 12 00:00:00 EST 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
25-0452-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
25-0452 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 EST 2012
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
The Journal of experimental medicine
Kaji T,Ishige A,Hikida M,Taka J,Hijikata A,Kubo M,Nagashima T,Takahashi Y,Kurosaki T,Okada M,Ohara O,Rajewsky K,Takemori T
25-0452 was used in Flow cytometry/Cell sorting to reveal distinct cellular pathways that select germline-encoded and somatically mutated antibodies into immunological memory.
Mon Oct 22 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
Effect of the poly(ethylene glycol) (PEG) density on the access and uptake of particles by antigen-presenting cells (APCs) after subcutaneous administration.
Molecular pharmaceutics
Zhan X,Tran KK,Shen H
25-0452 was used in Flow cytometry/Cell sorting to study the effect of PEGylation on the lymphatic trafficking and accumulation of particles in draining lymph nodes.
Mon Dec 03 00:00:00 EST 2012
Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
International immunology
Iseki M,Omori-Miyake M,Xu W,Sun X,Takaki S,Rawlings DJ,Ziegler SF
25-0452 was used in Flow cytometry/Cell sorting to demonstrate that thymic stromal lymphopoietin levels are an important factor in B-cell homeostasis and humoral autoimmunity.
Thu Mar 01 00:00:00 EST 2012
Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells.
Molecular & cellular proteomics : MCP
Klimmeck D,Hansson J,Raffel S,Vakhrushev SY,Trumpp A,Krijgsveld J
25-0452 was used in Flow cytometry/Cell sorting to discern the distinct signatures of multipotent progenitors and myeloid committed cells.
Wed Aug 01 00:00:00 EDT 2012
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.
Blood
Tian L,Altin JA,Makaroff LE,Franckaert D,Cook MC,Goodnow CC,Dooley J,Liston A
25-0452 was used in Flow cytometry/Cell sorting to demonstrate that Th2-driven diseases may be more responsive to regulatory T-cell manipulation.
Thu Aug 18 00:00:00 EDT 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
25-0452 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants.
The Journal of experimental medicine
Purtha WE,Tedder TF,Johnson S,Bhattacharya D,Diamond MS
25-0452 was used in Flow cytometry/Cell sorting to study the ability of memory B cells to target mutant viral epitopes.
Mon Dec 19 00:00:00 EST 2011
T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.
PLoS pathogens
Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ
25-0452 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.
Wed Jun 01 00:00:00 EDT 2011
A novel platform to produce human monoclonal antibodies: The next generation of therapeutic human monoclonal antibodies discovery.
mAbs
Duvall M,Bradley N,Fiorini RN
25-0452 was used in Flow cytometry/Cell sorting to study platforms upon which to produce therapeutic human monoclonal antibodies.
Mon Aug 15 00:00:00 EDT 2011
Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Merck E,Lees RK,Voyle RB,Held W,MacDonald HR
25-0452 was used in Flow cytometry/Cell sorting to investigate the role of Ly49D-mediated ITAM signaling, showing that it impairs development by bypassing the pre-TCR checkpoint.
Fri Jul 01 00:00:00 EDT 2011
Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Kaplan IM,Morisot S,Heiser D,Cheng WC,Kim MJ,Civin CI
25-0452 was used in Flow cytometry/Cell sorting to characterise hematopoiesis in TTP KO mice to show that TTP is a master regulator of inflammatory cytokine expression during homeostasis that controls granulocyte production.
Tue Mar 01 00:00:00 EST 2011
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.
PloS one
Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2011
Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice.
Journal of parasitology research
Bockstal V,Geurts N,Magez S
25-0452 was used in Flow cytometry/Cell sorting to investigate the effects of a blood-stage Plasmodium chabaudi infection in the spleen and bone marrow of mice.
Thu Jul 14 00:00:00 EDT 2011
Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.
Journal of molecular biology
Corpora T,Roudaia L,Oo ZM,Chen W,Manuylova E,Cai X,Chen MJ,Cierpicki T,Speck NA,Bushweller JH
25-0452 was used in Flow cytometry/Cell sorting to elucidate the structure and function of the AML1-ETO NHR3-PKA(RIIα) complex.
Fri Sep 24 00:00:00 EDT 2010
Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Elftman MD,Hunzeker JT,Mellinger JC,Bonneau RH,Norbury CC,Truckenmiller ME
25-0452 was used in Flow cytometry/Cell sorting to investigate the specific mechanism for psychological stress-induced suppression of immune responses.
Mon Feb 15 00:00:00 EST 2010
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.
Experimental hematology
Challen GA,Goodell MA
25-0452 was used in Flow cytometry/Cell sorting to study how Runx1 isoforms hold similar functions in adult hematopoietic stem cells, but show differential expression patterns during hematopoietic development.
Sat May 01 00:00:00 EDT 2010
Additive and global functions of HoxA cluster genes in mesoderm derivatives.
Developmental biology
Di-Poï N,Koch U,Radtke F,Duboule D
25-0452 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.
Sat May 15 00:00:00 EDT 2010
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function.
Blood
Lee JJ,Rauter I,Garibyan L,Ozcan E,Sannikova T,Dillon SR,Cruz AC,Siegel RM,Bram R,Jabara H,Geha RS
25-0452 was used in Flow cytometry/Cell sorting to define the consequence of the A181E mutation on TACI function.
Thu Sep 10 00:00:00 EDT 2009
Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement.
Journal of immunology (Baltimore, Md. : 1950)
Yunk L,Meng W,Cohen PL,Eisenberg RA,Luning Prak ET
25-0452 was used in Flow cytometry/Cell sorting to investigate the antibody heavy chain rearrangement that preceeds B cell receptor expression.
Wed Jul 01 00:00:00 EDT 2009
IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Kasai H,Watanabe A,Lai AY,Kondo M
25-0452 was used in Flow cytometry/Cell sorting to investigate when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice, showing that IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Tue Jul 01 00:00:00 EDT 2008
Homologous recombination is necessary for normal lymphocyte development.
Molecular and cellular biology
Caddle LB,Hasham MG,Schott WH,Shirley BJ,Mills KD
25-0452 was used in Flow cytometry/Cell sorting to discover that homologous recombination is necessary for normal lymphocyte development.
Tue Apr 01 00:00:00 EDT 2008
p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
PloS one
Cheng N,van de Wetering CI,Knudson CM
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Apr 02 00:00:00 EDT 2008
Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis.
European journal of immunology
Sireci G,Russo D,Dieli F,Porcelli SA,Taniguchi M,La Manna MP,Di Liberto D,Scarpa F,Salerno A
25-0452 was used in Flow cytometry/Cell sorting to study renal functions and autoantibody production in aged Ja281 KO mice lacking iNKT cells.
Thu Feb 01 00:00:00 EST 2007
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2007
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Molecular and cellular biology
Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2006
Type I interferons protect mice against enterovirus 71 infection.
The Journal of general virology
Liu ML,Lee YP,Wang YF,Lei HY,Liu CC,Wang SM,Su IJ,Wang JR,Yeh TM,Chen SH,Yu CK
25-0452 was used in Flow cytometry/Cell sorting to investigate the contribution of type I interferons to protection against infection with enterovirus 71, showing that they are protective.
Thu Dec 01 00:00:00 EST 2005
A role for brain-derived neurotrophic factor in B cell development.
Journal of neuroimmunology
Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA
Wed Jun 01 00:00:00 EDT 2005
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
Molecular and cellular biology
Pan L,Sato S,Frederick JP,Sun XH,Zhuang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 25-0452-82) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 1999
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-RA3-6B2-RE-AV-20170920122035.jpg?time=20240507?time=20240507 "CD45R (B220) Antibody (25-0452-82)")
