Invitrogen

CD3e Monoclonal Antibody (145-2C11), PE, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

97 Published Figures

209 References

View all (504) CD3 antibodies

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CD3e Antibody (12-0031-82) in Flow

Staining of C57Bl/6 splenocytes with 0.25 µg of Armenian Hamster IgG Isotype Control PE (Product # 12-4888-81) (blue histogram) or 0.25 µg of Anti-Mouse CD3e PE (purple histogram). Total viable cells were used for analysis.

Product Image Gallery

CD3e Antibody — Cdc42 contributes to HSPC defects in Vav-TRAF6 mice. ( a ) Flow cytometric analysis of donor-derived (gated on CD45.2 + ) myeloid (CD11b + ) and lymphoid (B220 + and CD3 + ) proportions 8 weeks post transplantation for competitively transplanted WT (C57Bl/6) and Vav-TRAF6 LT-HSC cells, and for Vav-TRAF6 LT-HSC cells treated in vitro with CASIN (or DMSO) for 24 h. * P < 0.05. ( b ) Summary of independent experiments of myeloid and lymphoid proportions of donor-derived (gated on CD45.2 + ) peripheral blood shown as a ratio (CD11b/[B220 + CD3]). ( c ) Peripheral blood myeloid (CD11b + ) and lymphoid (B220 + and CD3 + ) chimerism (CD45.2 + ) of donor-derived cells determined 8 weeks after competitive transplantation with Vav-TRAF6 LT-HSC treated with CASIN. ( n = 6 per group). * P < 0.005. ( d ) Donor-derived LT-HSC cells (CD45.2 + ) from Vav-TRAF6 mice and competitor BM cells (CD45.1 + ) were transplanted into lethally irradiated recipient mice (CD45.1 + ). 3 month post-secondary transplantation, the recipients were treated with 30 mg/kg CASIN and vehicle control (PBS) for 16 d. Ratio of donor-derived (gated on CD45.2 + ) and competitor-derived (gated on CD45.1 + ) myeloid (CD11b) and lymphoid (CD3 and B220) cells was determined by flow cytometry 4 weeks post-CASIN treatment in vivo . Donor-derived chimerism is normalized (1.0) for each mouse at week 1 ( n = 5 per group). * P = 0.007. Data are from two experiments ( b - d ; means and s.e.m.). {TM}

Product Details

12-0031-82

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

View 3 publications 3 publications

Flow Cytometry (Flow)

0.5 µg/test

View 205 publications 205 publications

Functional Assay (Functional)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

145-2C11

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_465496

Product Specific Information

Description: The 145-2C11 monoclonal antibody reacts with mouse CD3e, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits, gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Binding of 145-2C11 to TCR initiates the intracellular biochemical pathway resulting in cellular activation, proliferation, and apoptosis depending on specific conditions utilized. 145-2C11 is commonly used as a phenotypic marker for mouse T cells.

Applications Reported: The 145-2C11 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The 145-2C11 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Toxin expression during Staphylococcus aureus infection imprints host immunity to inhibit vaccine efficacy.

NPJ vaccines

Teymournejad O,Li Z,Beesetty P,Yang C,Montgomery CP

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Jan 24 00:00:00 EST 2023

NCR negative group 3 innate lymphoid cell (NCR^- ILC3) participates in abnormal pathology of lung in cigarette smoking-induced COPD mice.

Immunity, inflammation and disease

Chu S,Ma L,Yang X,Xiao B,Liang Y,Zheng S,Li L

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Machine learning approach for quantitative biodosimetry of partial-body or total-body radiation exposures by combining radiation-responsive biomarkers.

Scientific reports

Shuryak I,Nemzow L,Bacon BA,Taveras M,Wu X,Deoli N,Ponnaiya B,Garty G,Brenner DJ,Turner HC

12-0031-82 was used in Flow cytometry/Cell sorting to quantify and distinguish between PBI and TBI exposure via machine learning to a combination of radiation-responsive biomarkers and B and T cell counts.

Wed Jan 18 00:00:00 EST 2023

Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling.

Diabetes

Luan D,Dadpey B,Zaid J,Bridge-Comer PE,DeLuca JH,Xia W,Castle J,Reilly SM

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

miR-4759 suppresses breast cancer through immune checkpoint blockade.

Computational and structural biotechnology journal

Lin YZ,Liu SH,Wu WR,Shen YC,Wang YL,Liao CC,Lin PL,Chang H,Liu LC,Cheng WC,Wang SC

12-0031-82 was used in Flow Cytometry to demonstrate miR-4759 as a novel non-coding RNA which promotes anti-tumor immunity of breast cancer.

Sat Jan 15 00:00:00 EST 2022

Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound.

eLife

Roy R,Zayas J,Singh SK,Delgado K,Wood SJ,Mohamed MF,Frausto DM,Albalawi YA,Price TP,Estupinian R,Giurini EF,Kuzel TM,Zloza A,Reiser J,Shafikhani SH

12-0031-82 was used in Flow cytometry/Cell sorting to posit that CCL3 may have therapeutic potential for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement process which is intended to reset chronic ulcers into acute fresh wounds.

Thu Feb 03 00:00:00 EST 2022

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

Nature communications

Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L

12-0031-82 was used in Flow Cytometry to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.

Wed Feb 16 00:00:00 EST 2022

Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.

iScience

Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR

12-0031-82 was used in Immunohistochemistry to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.

Fri Jul 15 00:00:00 EDT 2022

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level.

Frontiers in pharmacology

Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H

12-0031-82 was used in Flow cytometry/Cell sorting to suggest different biological functions and distinct potential pathogenic genes for thoracic and abdominal aortic aneurysms.

Thu Feb 02 00:00:00 EST 2023

Circadian Dependence of the Acute Immune Response to Myocardial Infarction.

Frontiers in pharmacology

Kilgallen AB,van den Akker F,Feyen DAM,Crnko S,Snijders Blok CJB,Gremmels H,du Pré BC,Reijers R,Doevendans PA,de Jager SCA,Sluijter JPG,Sampaio-Pinto V,van Laake LW

12-0031-82 was used in Flow cytometry/Cell sorting to characterize the immune response and myocardial damage 3 hours after a MI occurs over a full twenty-four-hour period to investigate the role of the circadian rhythms in this response.

Sat Sep 16 00:00:00 EDT 2023

Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier-Free Nanoassembly of Fluorinated Prodrug and siRNA.

Advanced materials (Deerfield Beach, Fla.)

Wu P,Zhang H,Sun M,Mao S,He Q,Shi Y,Deng Y,Dong Z,Xu Q,Zhao C,Zhang W,Sun B

12-0031-82 was used in flow cytometry to develop a new kind of carrier-free nanoparticle to simultaneously deliver chemotherapeutic drug (doxorubicin, DOX), cytolytic peptide (melittin, MPI), and anti-TOX small interfering RNA (thymocyte selection-associated high mobility group box protein, TOX) using a fluorinated prodrug strategy.

Thu Sep 01 00:00:00 EDT 2022

Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.

Proceedings of the National Academy of Sciences of the United States of America

McCorkell KA,Jayachandran N,Cully MD,Freund-Brown J,Weinkopff T,Monslow J,Hu Y,Puré E,Freedman BD,Alvarez JI,Cancro MP,May MJ

12-0031-82 was used in Flow cytometry/Cell sorting to reveal that IKK-α in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and establish that LEC-intrinsic IKK-α is absolutely essential for LN formation.

Tue Nov 30 00:00:00 EST 2021

A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface.

Journal of cellular and molecular medicine

Wei DP,Li DD,Gu AQ,Ji WH,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Construction of a 3D brain extracellular matrix model to study the interaction between microglia and T cells in co-culture.

The European journal of neuroscience

Frühauf M,Zeitschel U,Höfling C,Ullm F,Rabiger FV,Alber G,Pompe T,Müller U,Roßner S

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity.

The Journal of biological chemistry

McAndrews KM,Che SPY,LeBleu VS,Kalluri R

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Aug 20 00:00:00 EDT 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Sat Jan 30 00:00:00 EST 2021

Obesity results in adipose tissue T cell exhaustion.

JCI insight

Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors.

Cell reports. Medicine

Kosti P,Opzoomer JW,Larios-Martinez KI,Henley-Smith R,Scudamore CL,Okesola M,Taher MYM,Davies DM,Muliaditan T,Larcombe-Young D,Woodman N,Gillett CE,Thavaraj S,Maher J,Arnold JN

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.

Nature communications

Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Jul 14 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.

Nature communications

Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y

12-0031-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.

Wed Aug 11 00:00:00 EDT 2021

Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.

iScience

Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.

Nature immunology

Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT

12-0031 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.

Fri May 01 00:00:00 EDT 2020

Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells.

Cancer immunology research

Wijewarnasuriya D,Bebernitz C,Lopez AV,Rafiq S,Brentjens RJ

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME

12-0031-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.

Sat Feb 01 00:00:00 EST 2020

Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME

Sat Feb 01 00:00:00 EST 2020

Antitumor Effect and Immune Response of Nanosecond Pulsed Electric Fields in Pancreatic Cancer.

Frontiers in oncology

Zhao J,Chen S,Zhu L,Zhang L,Liu J,Xu D,Tian G,Jiang T

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease.

Experimental and therapeutic medicine

Li W,Chen S,Luo Y,Xia Y,Ma Q,Yao Q,Wu J

12-0031 was used in Flow cytometry/Cell sorting to investigate the infiltration of T cells in lesions in the central nervous system, in patients with and without Parkinson's Disease.

Sat Aug 01 00:00:00 EDT 2020

Impact of S1P Mimetics on Mesenteric Ischemia/Reperfusion Injury.

Pharmaceuticals (Basel, Switzerland)

Potì F,Giorgio C,Zini I,Nofer JR,Vivo V,Palese S,Ballabeni V,Barocelli E,Bertoni S

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Oct 09 00:00:00 EDT 2020

CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.

FEBS open bio

Liu Y,Gao Y,Hao H,Hou T

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

IDO1⁺ Paneth cells promote immune escape of colorectal cancer.

Communications biology

Pflügler S,Svinka J,Scharf I,Crncec I,Filipits M,Charoentong P,Tschurtschenthaler M,Kenner L,Awad M,Stift J,Schernthanner M,Bischl R,Herndler-Brandstetter D,Glitzner E,Moll HP,Casanova E,Timelthaler G,Sibilia M,Gnant M,Lax S,Thaler J,Müller M,Strobl B,Mohr T,Kaser A,Trajanoski Z,Heller G,Eferl R

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.

Cell reports

Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Jun 17 00:00:00 EDT 2021

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.

Oncoimmunology

Cervera-Carrascon V,Quixabeira DCA,Santos JM,Havunen R,Zafar S,Hemminki O,Heiniö C,Munaro E,Siurala M,Sorsa S,Mirtti T,Järvinen P,Mildh M,Nisen H,Rannikko A,Anttila M,Kanerva A,Hemminki A

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition.

Oncoimmunology

Cervera-Carrascon V,Quixabeira DCA,Santos JM,Havunen R,Zafar S,Hemminki O,Heiniö C,Munaro E,Siurala M,Sorsa S,Mirtti T,Järvinen P,Mildh M,Nisen H,Rannikko A,Anttila M,Kanerva A,Hemminki A

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

G protein-coupled receptor 68 increases the number of B lymphocytes.

American journal of blood research

He X,Feng S,Hawkins C,Lawley L,Fan W,Xu Y,Zha XM,Fang J

12-0031 was used in Flow cytometry/Cell sorting to indicate that Gpr68 expression is upregulated in hematopoietic cells upon aging and during hematopoietic regeneration that ends up with increased number of B lymphocytes.

Mon Sep 28 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.

STAR protocols

Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jun 19 00:00:00 EDT 2020

Resident macrophages acquire innate immune memory in staphylococcal skin infection.

eLife

Feuerstein R,Forde AJ,Lohrmann F,Kolter J,Ramirez NJ,Zimmermann J,Gomez de Agüero M,Henneke P

12-0031 was used in Flow cytometry/Cell sorting to show that resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.

Wed Jul 08 00:00:00 EDT 2020

Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.

Frontiers in pharmacology

Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y

12-0031-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.

Tue Feb 16 00:00:00 EST 2021

The cis-Regulatory Atlas of the Mouse Immune System.

Cell

Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C

12-0031-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.

Thu Feb 07 00:00:00 EST 2019

Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.

Clinical cancer research : an official journal of the American Association for Cancer Research

Jiang H,Shin DH,Nguyen TT,Fueyo J,Fan X,Henry V,Carrillo CC,Yi Y,Alonso MM,Collier TL,Yuan Y,Lang FF,Gomez-Manzano C

12-0031 was used in Flow cytometry/Cell sorting to show that localized intratumoral injection of Delta-24-RGDOX induces an in situ antovaccination of the treated melanoma, the effect of which changes the immune landscape of the treated mice, resulting in systemic immunity against disseminated s.c. and i.c. tumors.

Fri Nov 15 00:00:00 EST 2019

1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension.

British journal of pharmacology

Mikolajczyk TP,Nosalski R,Skiba DS,Koziol J,Mazur M,Justo-Junior AS,Kowalczyk P,Kusmierczyk Z,Schramm-Luc A,Luc K,Maffia P,Graham D,Kiss AK,Naruszewicz M,Guzik TJ

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2019

CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.

Oncology reports

Li Y,Zhao C,Liu J,Lu Z,Lu M,Gu J,Liu R

12-0031 was used in Flow cytometry/Cell sorting to investigate whether CD1d expression on dendritic cells is capable of enhancing anti-tumour immunity, particularly T-cell related immunity.

Wed May 01 00:00:00 EDT 2019

CD160 serves as a negative regulator of NKT cells in acute hepatic injury.

Nature communications

Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Jul 22 00:00:00 EDT 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

STAT1 signaling shields T cells from NK cell-mediated cytotoxicity.

Nature communications

Kang YH,Biswas A,Field M,Snapper SB

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

Cell stem cell

McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA

12-0031 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.

Thu Aug 01 00:00:00 EDT 2019

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8⁺ Dendritic Cells.

Frontiers in immunology

Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T

12-0031-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.

Tue Oct 27 00:00:00 EDT 2020

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.

Frontiers in immunology

Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ

12-0031-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.

Tue Oct 13 00:00:00 EDT 2020

DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.

Nature medicine

Xiao Q,Wu J,Wang WJ,Chen S,Zheng Y,Yu X,Meeth K,Sahraei M,Bothwell ALM,Chen L,Bosenberg M,Chen J,Sexl V,Sun L,Li L,Tang W,Wu D

12-0031 was used in Flow Cytometry to identify a novel tumour immune-suppressive mechanism and immunotherapeutic targets particularly relevant for colorectal cancers and a subset of melanomas.

Thu Mar 01 00:00:00 EST 2018

Quiescent Tissue Stem Cells Evade Immune Surveillance.

Immunity

Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD

12-0031 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.

Tue Feb 20 00:00:00 EST 2018

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs.

Nature genetics

Gozdecka M,Meduri E,Mazan M,Tzelepis K,Dudek M,Knights AJ,Pardo M,Yu L,Choudhary JS,Metzakopian E,Iyer V,Yun H,Park N,Varela I,Bautista R,Collord G,Dovey O,Garyfallos DA,De Braekeleer E,Kondo S,Cooper J,Göttgens B,Bullinger L,Northcott PA,Adams D,Vassiliou GS,Huntly BJP

12-0031-82 was used in Flow Cytometry to demonstrate concomitant loss/mutation of KDM6A (UTX) and UTY in multiple human cancers.

Fri Jun 01 00:00:00 EDT 2018

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.

The Journal of experimental medicine

Nagase R,Inoue D,Pastore A,Fujino T,Hou HA,Yamasaki N,Goyama S,Saika M,Kanai A,Sera Y,Horikawa S,Ota Y,Asada S,Hayashi Y,Kawabata KC,Takeda R,Tien HF,Honda H,Abdel-Wahab O,Kitamura T

12-0031 was used in Flow cytometry/Cell sorting to study the effects of physiological expression of a C-terminal truncated AsXenopus laevis1 mutant in vivo.

Mon Jun 04 00:00:00 EDT 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

Gli3 in fetal thymic epithelial cells promotes thymocyte positive selection and differentiation by repression of Shh.

Development (Cambridge, England)

Solanki A,Yanez DC,Ross S,Lau CI,Papaioannou E,Li J,Saldaña JI,Crompton T

Wed Jan 31 00:00:00 EST 2018

On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation.

Drug delivery

Shahzad KA,Wan X,Zhang L,Pei W,Zhang A,Younis M,Wang W,Shen C

12-0031 was used in Flow cytometry/Cell sorting to examine the direct and antigen-specific modulation on T cells by nanoparticles and combined use of multiple regulatory molecules.

Thu Nov 01 00:00:00 EDT 2018

Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells.

Experimental hematology

Shi X,Kitano A,Jiang Y,Luu V,Hoegenauer KA,Nakada D

12-0031 was used in Flow cytometry/Cell sorting to establish that the CRISPR/Cas9-mediated multiplex mutagenesis can be used to engineer a variety of murine models of hematological malignancies with complex genetic architectures seen in human disease.

Wed Aug 01 00:00:00 EDT 2018

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Journal of neuroimmunology

Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response.

Scientific reports

Rodríguez-Baena FJ,Redondo-García S,Peris-Torres C,Martino-Echarri E,Fernández-Rodríguez R,Plaza-Calonge MDC,Anderson P,Rodríguez-Manzaneque JC

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Aug 30 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.

Nature communications

Efremova M,Rieder D,Klepsch V,Charoentong P,Finotello F,Hackl H,Hermann-Kleiter N,Löwer M,Baier G,Krogsdam A,Trajanoski Z

12-0031 was used in Flow cytometry/Cell sorting to demonstrate that neutral evolution is another force that contributes to sculpting the tumor and that checkpoint blockade effectively enforces T-cell-dependent immunoselective pressure.

Tue Jan 02 00:00:00 EST 2018

Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer.

Nature communications

Nam J,Son S,Ochyl LJ,Kuai R,Schwendeman A,Moon JJ

12-0031 was used in Flow cytometry/Cell sorting to show that chemo-photothermal therapy tuned to elicit anti-tumour immunity can exert striking therapeutic effects against primary and disseminated tumours.

Wed Mar 14 00:00:00 EDT 2018

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.

Cell reports

Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S

Tue Sep 11 00:00:00 EDT 2018

Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade.

Nature communications

Klepsch V,Hermann-Kleiter N,Do-Dinh P,Jakic B,Offermann A,Efremova M,Sopper S,Rieder D,Krogsdam A,Gamerith G,Perner S,Tzankov A,Trajanoski Z,Wolf D,Baier G

12-0031 was used in Flow cytometry/Cell sorting to define NR2F6 as an intracellular immune checkpoint with potential as a therapeutic target in cancer treatment.

Wed Apr 18 00:00:00 EDT 2018

Reduced expression of C/EBPβ-LIP extends health and lifespan in mice.

eLife

Müller C,Zidek LM,Ackermann T,de Jong T,Liu P,Kliche V,Zaini MA,Kortman G,Harkema L,Verbeek DS,Tuckermann JP,von Maltzahn J,de Bruin A,Guryev V,Wang ZQ,Calkhoven CF

12-0031 was used in Flow cytometry/Cell sorting to reveal a role for C/EBPβ in the aging process and suggest that restriction of LIP expression sustains health and fitness.

Mon Jun 04 00:00:00 EDT 2018

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Immunity, inflammation and disease

Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P

12-0031 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.

Fri Jun 01 00:00:00 EDT 2018

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Cell

Kortlever RM,Sodir NM,Wilson CH,Burkhart DL,Pellegrinet L,Brown Swigart L,Littlewood TD,Evan GI

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Nov 30 00:00:00 EST 2017

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Immunity

Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY

12-0031 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.

Tue Nov 21 00:00:00 EST 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Gli1⁺ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Cell stem cell

Schneider RK,Mullally A,Dugourd A,Peisker F,Hoogenboezem R,Van Strien PMH,Bindels EM,Heckl D,Büsche G,Fleck D,Müller-Newen G,Wongboonsin J,Ventura Ferreira M,Puelles VG,Saez-Rodriguez J,Ebert BL,Humphreys BD,Kramann R

12-0031 was used in Flow cytometry/Cell sorting to study the cellular origin of bone marrow fibrosis.

Thu Jun 01 00:00:00 EDT 2017

T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma.

Circulation research

Sun XN,Li C,Liu Y,Du LJ,Zeng MR,Zheng XJ,Zhang WC,Liu Y,Zhu M,Kong D,Zhou L,Lu L,Shen ZX,Yi Y,Du L,Qin M,Liu X,Hua Z,Sun S,Yin H,Zhou B,Yu Y,Zhang Z,Duan SZ

12-0031 was used in Flow cytometry/Cell sorting to determine the role of T-cell mineralocorticoid receptor in blood pressure regulation and explore the mechanism.

Fri May 12 00:00:00 EDT 2017

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.

Circulation research

Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R

12-0031 was used in Flow cytometry/Cell sorting to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.

Fri Mar 31 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

PTEN drives Th17 cell differentiation by preventing IL-2 production.

The Journal of experimental medicine

Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Nov 06 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

12-0031 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.

Mon Jun 05 00:00:00 EDT 2017

Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.

The Journal of allergy and clinical immunology

Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM

12-0031 was used in Flow cytometry/Cell sorting to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.

Wed Feb 01 00:00:00 EST 2017

Combined blockade of the IL-13 and IL-33 pathways leads to a greater inhibition of type 2 inflammation over inhibition of either pathway alone.

The Journal of allergy and clinical immunology

Ramirez-Carrozzi V,Sambandam A,Zhou M,Yan D,Kang J,Wu X,Suto E,Baca M,Austin C,Xu M,Lee W,Pappu R

12003182 was used in flow cytometry to study the effect of IL-13 and IL-33 pathways in dysregulated type 2 inflammation.

Wed Feb 01 00:00:00 EST 2017

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

12-0031-82 was used in Flow cytometry/Cell sorting to show that transfusion of red blood cells expressing self-antigen epitopes can alleviate and even prevent signs of disease in experimental autoimmune encephalomyelitis, as well as maintain normoglycemia in a mouse model of type 1 diabetes.

Tue Mar 21 00:00:00 EDT 2017

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b⁺Ly6G⁺ intratumor myeloid cells through the TICAM-1 signaling pathway.

Cell death and differentiation

Shime H,Matsumoto M,Seya T

12-0031 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.

Wed Mar 01 00:00:00 EST 2017

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice.

Frontiers in immunology

Soldemo M,Àdori M,Stark JM,Feng Y,Tran K,Wilson R,Yang L,Guenaga J,Wyatt RT,Karlsson Hedestam GB

12-0031 was used in Flow cytometry/Cell sorting to investigate if glutaraldehyde fixation affects other aspects of the soluble HIV-1 envelope glycoprotein-specific immune response.

Wed Nov 20 00:00:00 EST 2019

Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells.

Frontiers in immunology

Zayoud M,Marcu-Malina V,Vax E,Jacob-Hirsch J,Elad-Sfadia G,Barshack I,Kloog Y,Goldstein I

12-0031 was used in Flow cytometry/Cell sorting to test the therapeutic and immunomodulatory effects of farnesylthiosalicylic acid and its derivative 5-fluoro-FTS in the rat adjuvant-induced arthritis model.

Wed Nov 20 00:00:00 EST 2019

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.

Journal of leukocyte biology

Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

12-0031 was used in Flow cytometry/Cell sorting to show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans.

Sun Jan 01 00:00:00 EST 2017

Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.

Journal of cellular and molecular medicine

Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Cytochrome P450 26A1 modulates natural killer cells in mouse early pregnancy.

Journal of cellular and molecular medicine

Meng CY,Li ZY,Fang WN,Song ZH,Yang DD,Li DD,Yang Y,Peng JP

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

The common parasite Toxoplasma gondii induces prostatic inflammation and microglandular hyperplasia in a mouse model.

The Prostate

Colinot DL,Garbuz T,Bosland MC,Wang L,Rice SE,Sullivan WJ,Arrizabalaga G,Jerde TJ

12-0031-82 was used in Flow cytometry/Cell sorting to report that T. gondii chronically encysts and induces chronic inflammation within the prostate of any species.

Sat Jul 01 00:00:00 EDT 2017

Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice.

Molecular medicine reports

Tang A,Li C,Chen Z,Li T

12-0031 was used in Flow cytometry/Cell sorting to suggest that anti-CD20 and IL-10 treatment in NOD mice can modulate the immune functions by up-regulating GATA-3 and IL-4 expression as well as down-regulating T-bet and IFN-γ expression.

Sun Oct 01 00:00:00 EDT 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jan 06 00:00:00 EST 2017

The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue.

Nature microbiology

Grau KR,Roth AN,Zhu S,Hernandez A,Colliou N,DiVita BB,Philip DT,Riffe C,Giasson B,Wallet SM,Mohamadzadeh M,Karst SM

12-0031 was used in Flow cytometry/Cell sorting to analyse in vivo norovirus cell tropism in orally inoculated, immunocompetent hosts at the peak of acute infection.

Fri Dec 01 00:00:00 EST 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

Suppressive IL-17A⁺Foxp3⁺ and ex-Th17 IL-17A^negFoxp3⁺ T_reg cells are a source of tumour-associated T_reg cells.

Nature communications

Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N

12-0031 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.

Tue Mar 14 00:00:00 EDT 2017

Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.

JCI insight

Ikutani M,Tsuneyama K,Kawaguchi M,Fukuoka J,Kudo F,Nakae S,Arita M,Nagai Y,Takaki S,Takatsu K

12-0031 was used in Flow cytometry/Cell sorting to demonstrate a previously unrecognized mechanism in the development of pulmonary arterial hypertrophy and the causative roles of ILC2 in the process.

Thu Apr 06 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.

The Journal of clinical investigation

Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J

12-0031 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.

Thu Dec 01 00:00:00 EST 2016

Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.

Autophagy

Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Aug 02 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice.

Infection and immunity

Ruan S,Samuelson DR,Assouline B,Morre M,Shellito JE

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

The dual role of NK cells in antitumor reactions triggered by ionizing radiation in combination with hyperthermia.

Oncoimmunology

Finkel P,Frey B,Mayer F,Bösl K,Werthmöller N,Mackensen A,Gaipl US,Ullrich E

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.

Nature communications

Xu Y,Zhao F,Qiu Q,Chen K,Wei J,Kong Q,Gao B,Melo-Cardenas J,Zhang B,Zhang J,Song J,Zhang DD,Zhang J,Fan Y,Li H,Fang D

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jul 15 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.

Nature communications

Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Oct 21 00:00:00 EDT 2016

miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.

Scientific reports

Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B

12-0031 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.

Mon Feb 01 00:00:00 EST 2016

SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.

Oncotarget

Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG

12-0031 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.

Tue Dec 13 00:00:00 EST 2016

The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells.

PloS one

Yasuoka T,Kuwahara M,Yamada T,Maruyama S,Suzuki J,Taniguchi M,Yasukawa M,Yamashita M

12-0031 was used in Flow cytometry/Cell sorting to investigate the impact of Gfi1-deficiency on the differentiation of invariant natural killer T cells in mice.

Tue Jul 18 00:00:00 EDT 2017

Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.

PloS one

Jonas BA,Johnson C,Gratzinger D,Majeti R

12-0031 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.

Wed Jul 26 00:00:00 EDT 2017

Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae.

PLoS neglected tropical diseases

Pionnier N,Brotin E,Karadjian G,Hemon P,Gaudin-Nomé F,Vallarino-Lhermitte N,Nieguitsila A,Fercoq F,Aknin ML,Marin-Esteban V,Chollet-Martin S,Schlecht-Louf G,Bachelerie F,Martin C

12-0031 was used in Flow cytometry/Cell sorting to demonstrate that neutrophils contribute to early anti-filarial host responses via oxidative burst, degranulation and NETosis.

Fri Apr 01 00:00:00 EDT 2016

Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.

Scientific reports

Song ZH,Li ZY,Li DD,Fang WN,Liu HY,Yang DD,Meng CY,Yang Y,Peng JP

12-0031 was used in Flow cytometry/Cell sorting to identify a new mechanism by which seminal plasma could influence inflammation in the uterus through the γδ T/IL-17 pathway.

Mon Apr 25 00:00:00 EDT 2016

Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response.

PloS one

Zákostelská Z,Málková J,Klimešová K,Rossmann P,Hornová M,Novosádová I,Stehlíková Z,Kostovčík M,Hudcovic T,Štepánková R,Jůzlová K,Hercogová J,Tlaskalová-Hogenová H,Kverka M

12-0031 was used in Flow cytometry/Cell sorting to investigate the link between gut microbiota, T cells and the formation of psoriatic lesions in a mouse model of psoriasis.

Wed Jul 26 00:00:00 EDT 2017

GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions.

Nature biotechnology

Agudo J,Ruzo A,Park ES,Sweeney R,Kana V,Wu M,Zhao Y,Egli D,Merad M,Brown BD

12-0031 was used in Flow cytometry/Cell sorting to generate and use GFP-specific CD8 T cells to investigate less understood cell types and their interactions with the immune system.

Tue Dec 01 00:00:00 EST 2015

The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.

Cell

Karreth FA,Reschke M,Ruocco A,Ng C,Chapuy B,Léopold V,Sjoberg M,Keane TM,Verma A,Ala U,Tay Y,Wu D,Seitzer N,Velasco-Herrera Mdel C,Bothmer A,Fung J,Langellotto F,Rodig SJ,Elemento O,Shipp MA,Adams DJ,Chiarle R,Pandolfi PP

12-0031 was used in Flow cytometry/Cell sorting to find that transcriptional or genomic aberrations of BRAFP1 occur frequently in multiple human cancers, including B cell lymphomas.

Thu Apr 09 00:00:00 EDT 2015

Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.

Nature immunology

Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D

12-0031 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.

Fri May 01 00:00:00 EDT 2015

An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.

The Journal of experimental medicine

Hao B,Naik AK,Watanabe A,Tanaka H,Chen L,Richards HW,Kondo M,Taniuchi I,Kohwi Y,Kohwi-Shigematsu T,Krangel MS

12-0031 was used in Flow cytometry/Cell sorting to provide a novel framework for understanding ASE function for gene expression in double-positive thymocytes.

Mon May 04 00:00:00 EDT 2015

Premature thymic involution is independent of structural plasticity of the thymic stroma.

European journal of immunology

Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A

12-0031 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.

Fri May 01 00:00:00 EDT 2015

Activated NKT cells imprint NK-cell differentiation, functionality and education.

European journal of immunology

Riese P,Trittel S,May T,Cicin-Sain L,Chambers BJ,Guzmán CA

12-0031 was used in Flow cytometry/Cell sorting to study the cellular cross-talk between natural killer T cells and natural killer cells.

Mon Jun 01 00:00:00 EDT 2015

Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.

Molecular therapy oncolytics

Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA

12-0031 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.

Wed Apr 27 00:00:00 EDT 2016

Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.

Journal of immunology (Baltimore, Md. : 1950)

Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J

12-0031 was used in Flow cytometry/Cell sorting to study cell-specific deletion of C5aR1 using a GFP-reporter knock-in mouse model.

Sun Feb 15 00:00:00 EST 2015

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

12-0031-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.

Mon Aug 01 00:00:00 EDT 2016

The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Cell reports

Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8⁺ T-cell responses and immune memory.

Oncoimmunology

Wu J,Waxman DJ

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.

PloS one

Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue May 24 00:00:00 EDT 2016

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model.

BMC cancer

Gillgrass AE,Chew MV,Krneta T,Ashkar AA

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2015

Neonatal microbial colonization in mice promotes prolonged dominance of CD11b(+)Gr-1(+) cells and accelerated establishment of the CD4(+) T cell population in the spleen.

Immunity, inflammation and disease

Kristensen MB,Metzdorff SB,Bergström A,Damlund DS,Fink LN,Licht TR,Frøkiær H

12-0031 was used in Flow cytometry/Cell sorting to assess the microbial influence on postnatal haematopoiesis.

Tue Sep 01 00:00:00 EDT 2015

Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.

Journal of translational medicine

Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J

12-0031 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.

Fri Jul 17 00:00:00 EDT 2015

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

PLoS genetics

Gralinski LE,Ferris MT,Aylor DL,Whitmore AC,Green R,Frieman MB,Deming D,Menachery VD,Miller DR,Buus RJ,Bell TA,Churchill GA,Threadgill DW,Katze MG,McMillan L,Valdar W,Heise MT,Pardo-Manuel de Villena F,Baric RS

12-0031 was used in Flow cytometry/Cell sorting to validate the Collaborative Cross platform as a resource for uncovering the genetic contributions of complex traits in microbial diseases, inflammation and viral replication.

Thu Oct 01 00:00:00 EDT 2015

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.

PloS one

Charmsaz S,Beckett K,Smith FM,Bruedigam C,Moore AS,Al-Ejeh F,Lane SW,Boyd AW

12-0031 was used in Flow cytometry/Cell sorting to explore the role of EphA2 in haematopoiesis and leukaemogenesis.

Tue May 03 00:00:00 EDT 2016

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.

Science translational medicine

Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.

Mucosal immunology

Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M

12-0031 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.

Sat Nov 01 00:00:00 EDT 2014

Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection.

PLoS pathogens

Maroof A,Yorgensen YM,Li Y,Evans JT

12-0031 was used in Flow cytometry/Cell sorting to highlight the importance of both route of vaccination and adjuvant selection in vaccine development.

Wed Jan 01 00:00:00 EST 2014

Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion.

European journal of immunology

Larsen J,Dall M,Antvorskov JC,Weile C,Engkilde K,Josefsen K,Buschard K

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.

Journal of leukocyte biology

Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A

12-0031 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.

Sat Nov 01 00:00:00 EDT 2014

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.

Immunology and cell biology

Le Blon D,Hoornaert C,Daans J,Santermans E,Hens N,Goossens H,Berneman Z,Ponsaerts P

12-0031 was used in Flow cytometry/Cell sorting to characterise the distribution of microglia and macrophages in the mouse brain following mesenchymal stem cell implantation, showing that resident immune cells surround the graft site while peripheral immune cells invade the graft.

Mon Sep 01 00:00:00 EDT 2014

Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.

Laboratory investigation; a journal of technical methods and pathology

Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X

12-0031 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..

Sat Feb 01 00:00:00 EST 2014

Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.

Journal of immunology (Baltimore, Md. : 1950)

Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

12-0031 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.

Fri Aug 01 00:00:00 EDT 2014

Specific increase in potency via structure-based design of a TCR.

Journal of immunology (Baltimore, Md. : 1950)

Malecek K,Grigoryan A,Zhong S,Gu WJ,Johnson LA,Rosenberg SA,Cardozo T,Krogsgaard M

12-0031 was used in Flow cytometry/Cell sorting to investigate mutations that can enhance binding affinity of a TCR for adoptive immunotherapy, producing an increase in potency.

Mon Sep 01 00:00:00 EDT 2014

Role of IL-17 and TGF-β in peritoneal adhesion formation after surgical trauma.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Wang G,Wu K,Li W,Zhao E,Shi L,Wang J,Shuai X,Cai K,Lu X,Tao K,Wang G

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2015

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.

PloS one

Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2015

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

CD8+T cell-specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8+T cell accumulation in tumors.

Molecular cancer

Hu J,Zhu S,Xia X,Zhang L,Kleinerman ES,Li S

12-0031 was used in Flow cytometry/Cell sorting to explore the impact of NKG2D expression on CD8+T cell infiltration and antitumour efficacy.

Mon Feb 24 00:00:00 EST 2014

Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.

PloS one

Maneva-Radicheva L,Amatya C,Parker C,Ellefson J,Radichev I,Raghavan A,Charles ML,Williams MS,Robbins MS,Savinov AY

12-0031 was used in Flow cytometry/Cell sorting to reveal that the protein, DM199, may benefit type 1 diabetics by attenuating autoimmunity and improving beta cell health.

Wed Jun 10 00:00:00 EDT 2015

The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition.

Blood

Fleischman AG,Maxson JE,Luty SB,Agarwal A,Royer LR,Abel ML,MacManiman JD,Loriaux MM,Druker BJ,Tyner JW

12-0031 was used in Flow cytometry/Cell sorting to show that a mutation causes a lethal neutrophilic neoplasma in mice that is responsive to JAK inhibition.

Thu Nov 21 00:00:00 EST 2013

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.

The Journal of experimental medicine

Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

12-0031 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.

Mon Apr 08 00:00:00 EDT 2013

Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.

Development (Cambridge, England)

Tober J,Yzaguirre AD,Piwarzyk E,Speck NA

12-0031 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.

Sun Sep 01 00:00:00 EDT 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

A new immuno-, dystrophin-deficient model, the NSG-mdx(4Cv) mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation.

Stem cells (Dayton, Ohio)

Arpke RW,Darabi R,Mader TL,Zhang Y,Toyama A,Lonetree CL,Nash N,Lowe DA,Perlingeiro RC,Kyba M

12-0031 was used in Flow cytometry/Cell sorting to highlight the potency of satellite cells to improve muscle function and the utility of the NSG-mdx(4Cv) model for studies on muscle regeneration.

Thu Aug 01 00:00:00 EDT 2013

High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis.

Clinical and experimental immunology

Wang J,Shan Y,Jiang Z,Feng J,Li C,Ma L,Jiang Y

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Differential effects of aging and sex on stroke induced inflammation across the lifespan.

Experimental neurology

Manwani B,Liu F,Scranton V,Hammond MD,Sansing LH,McCullough LD

12-0031 was used in Flow cytometry/Cell sorting to evaluate the relative contribution of several key factors determining stroke outcome.

Fri Nov 01 00:00:00 EDT 2013

IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.

Journal of immunology (Baltimore, Md. : 1950)

Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST

12-0031 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.

Sun Sep 01 00:00:00 EDT 2013

Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice.

Journal of cancer science & therapy

Zheng D,Chen H,Bartee MY,Williams J,Davids JA,Lomas DA,McFadden G,Lucas AR

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Aug 19 00:00:00 EDT 2013

Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3.

BMC infectious diseases

Zhang NZ,Huang SY,Zhou DH,Chen J,Xu Y,Tian WP,Lu J,Zhu XQ

12-0031 was used in Flow cytometry/Cell sorting to investigate the potentiality of protective immunity from DNA immunization, using the gene encoding calcium-dependent protein kinase 3.

Thu Oct 31 00:00:00 EDT 2013

CD4⁺ but not CD8⁺ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice.

Translational psychiatry

Rattazzi L,Piras G,Ono M,Deacon R,Pariante CM,D'Acquisto F

12-0031 was used in Flow cytometry/Cell sorting to understand the mechanisms linking an immunocompromised state to a variety of mood disorders.

Tue Jul 09 00:00:00 EDT 2013

Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants.

The Journal of biological chemistry

Jacobson LS,Lima H,Goldberg MF,Gocheva V,Tsiperson V,Sutterwala FS,Joyce JA,Gapp BV,Blomen VA,Chandran K,Brummelkamp TR,Diaz-Griffero F,Brojatsch J

12-0031 was used in Flow cytometry/Cell sorting to investigate how adjuvant-mediated necrotic cell death controls adjuvant-mediated immunity and how this may alter our design of more powerful, safer adjuvants.

Fri Mar 15 00:00:00 EDT 2013

Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.

PloS one

Jupelli M,Shimada K,Chiba N,Slepenkin A,Alsabeh R,Jones HD,Peterson E,Chen S,Arditi M,Crother TR

12-0031 was used in Flow cytometry/Cell sorting to investigate how chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis..

Sat Aug 02 00:00:00 EDT 2014

Transcription factor RORα is critical for nuocyte development.

Nature immunology

Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN

12-0031 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.

Sun Jan 22 00:00:00 EST 2012

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.

Blood

Greenbaum AM,Revollo LD,Woloszynek JR,Civitelli R,Link DC

12-0031 was used in Flow cytometry/Cell sorting to investigate whether N-cadherin expression on osteoblast lineage cells regulates HSC function and quiescence, showing that it is not required.

Thu Jul 12 00:00:00 EDT 2012

Thymus-autonomous T cell development in the absence of progenitor import.

The Journal of experimental medicine

Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR

12-0031 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.

Mon Jul 30 00:00:00 EDT 2012

IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin.

The Journal of allergy and clinical immunology

Salmond RJ,Mirchandani AS,Besnard AG,Bain CC,Thomson NC,Liew FY

12-0031 was used in Flow cytometry/Cell sorting to investigate the role of mTOR signalling in the activation of TH2, ILC and IL-33 inflammation responses.

Thu Nov 01 00:00:00 EDT 2012

Pulmonary T cell activation in response to chronic particulate air pollution.

American journal of physiology. Lung cellular and molecular physiology

Deiuliis JA,Kampfrath T,Zhong J,Oghumu S,Maiseyeu A,Chen LC,Sun Q,Satoskar AR,Rajagopalan S

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Feb 15 00:00:00 EST 2012

CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.

Journal of immunology (Baltimore, Md. : 1950)

Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH

12-0031 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.

Wed Feb 15 00:00:00 EST 2012

Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

American journal of physiology. Gastrointestinal and liver physiology

Ernst PB,Erickson LD,Loo WM,Scott KG,Wiznerowicz EB,Brown CC,Torres-Velez FJ,Alam MS,Black SG,McDuffie M,Feldman SH,Wallace JL,McKnight GW,Padol IT,Hunt RH,Tung KS

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

Species-specific activity of glycolipid ligands for invariant NKT cells.

Chembiochem : a European journal of chemical biology

Dangerfield EM,Cheng JM,Knight DA,Weinkove R,Dunbar PR,Hermans IF,Timmer MS,Stocker BL

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Jun 18 00:00:00 EDT 2012

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF.

The Journal of biological chemistry

Badeaux AI,Yang Y,Cardenas K,Vemulapalli V,Chen K,Kusewitt D,Richie E,Li W,Bedford MT

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Jan 02 00:00:00 EST 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.

European journal of microbiology & immunology

Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D

12-0031 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.

Fri Jun 01 00:00:00 EDT 2012

RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.

Immunity

Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F

12-0031 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.

Fri Mar 25 00:00:00 EDT 2011

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.

The Journal of experimental medicine

Christopher MJ,Rao M,Liu F,Woloszynek JR,Link DC

12-0031 was used in Flow cytometry/Cell sorting to suggest a model in which G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance.

Mon Feb 14 00:00:00 EST 2011

A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice.

Toxicology

Mustafa A,Holladay SD,Witonsky S,Sponenberg DP,Karpuzoglu E,Gogal RM

12-0031 was used in Flow cytometry/Cell sorting to investigate the effect of prenatal TCDD on the postnatal autoimmune status of C57BL/6 mice.

Sun Dec 18 00:00:00 EST 2011

Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.

Biology of reproduction

Meng J,Greenlee AR,Taub CJ,Braun RE

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2011

Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis.

Infection and immunity

Hsieh SH,Lin JS,Huang JH,Wu SY,Chu CL,Kung JT,Wu-Hsieh BA

12-0031 was used in Immunofluorescence on frozen tissues to investigate the effect of immunisation with apoptotic phagocytes containing heat-killed Histoplasma, showing that it activates functional CD8(+) T cells to protect against histoplasmosis.

Tue Nov 01 00:00:00 EDT 2011

Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo.

PloS one

Fuertes Marraco SA,Scott CL,Bouillet P,Ives A,Masina S,Vremec D,Jansen ES,O'Reilly LA,Schneider P,Fasel N,Shortman K,Strasser A,Acha-Orbea H

12-0031 was used in Flow cytometry/Cell sorting to elucidate the possible apoptotic mechanisms that control activated dendritic cell lifespan in response to PAMPs.

Fri Sep 30 00:00:00 EDT 2011

Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol.

PloS one

Hegde VL,Nagarkatti PS,Nagarkatti M

12-0031 was used in Flow cytometry/Cell sorting to ameliorate experimental autoimmune hepatitis following activation of TRPV1 receptors in myeloid-derived suppressor cells by cannabidiol.

Fri Apr 01 00:00:00 EDT 2011

Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

Immunity

Ohnmacht C,Schwartz C,Panzer M,Schiedewitz I,Naumann R,Voehringer D

12-0031 was used in Flow cytometry/Cell sorting to demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation.

Fri Sep 24 00:00:00 EDT 2010

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.

Blood

Huber S,Hoffmann R,Muskens F,Voehringer D

12-0031 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.

Thu Oct 28 00:00:00 EDT 2010

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.

Proceedings of the National Academy of Sciences of the United States of America

Létourneau S,van Leeuwen EM,Krieg C,Martin C,Pantaleo G,Sprent J,Surh CD,Boyman O

12-0031 was used in Flow cytometry/Cell sorting to show that IL-2 receptor alpha subunit CD25 plays a crucial role in IL-2 homeostasis.

Tue Feb 02 00:00:00 EST 2010

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice.

Obesity (Silver Spring, Md.)

Strissel KJ,DeFuria J,Shaul ME,Bennett G,Greenberg AS,Obin MS

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2010

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Gastroenterology

Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2009

Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection.

Brain, behavior, and immunity

Steelman AJ,Dean DD,Young CR,Smith R,Prentice TW,Meagher MW,Welsh CJ

12-0031 was used in Flow cytometry/Cell sorting to examine how stress during acute TMEV infection alters virus-specific cell mediated responses, showing that stress-induced immunosuppression enhances viral persistence.

Sat Aug 01 00:00:00 EDT 2009

Tracking epitope-specific T cells.

Nature protocols

Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Tue Jun 30 00:00:00 EDT 2009

STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.

Haematologica

Thawani N,Tam M,Stevenson MM

12-0031 was used in Flow cytometry/Cell sorting to investigate the role of STAT6-mediated responses in erythropoietic suppression during acute malaria infection in mice.

Sun Feb 01 00:00:00 EST 2009

Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor.

Journal of leukocyte biology

Evans DL,Connor MA,Moss LD,Lackay S,Leary JH,Krunkosky T,Jaso-Friedmann L

12-0031 was used in Flow cytometry/Cell sorting to identify and investigate the function of a H1x-like protein.

Wed Jul 01 00:00:00 EDT 2009

Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.

BMC microbiology

Petersen A,Heegaard PM,Pedersen AL,Andersen JB,Sørensen RB,Frøkiaer H,Lahtinen SJ,Ouwehand AC,Poulsen M,Licht TR

12-0031 was used in Flow cytometry/Cell sorting to examine whether Salmonella infection could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles.

Mon Nov 30 00:00:00 EST 2009

Psychological stress exacerbates primary vaginal herpes simplex virus type 1 (HSV-1) infection by impairing both innate and adaptive immune responses.

Brain, behavior, and immunity

Ashcraft KA,Bonneau RH

12-0031 was used in Flow cytometry/Cell sorting to determine the effect of psychological stress on the immune response to, and pathogenesis of, vaginal herpes simplex virus infection.

Sat Nov 01 00:00:00 EDT 2008

Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.

International archives of allergy and immunology

Muralimohan G,Rossi RJ,Vella AT

12-0031 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.

Tue Sep 09 00:00:00 EDT 2008

p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.

PloS one

Cheng N,van de Wetering CI,Knudson CM

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2008

Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.

European journal of immunology

Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ

12-0031-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.

Thu Nov 01 00:00:00 EDT 2007

Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.

Infection and immunity

Schierloh P,Yokobori N,Alemán M,Landoni V,Geffner L,Musella RM,Castagnino J,Baldini M,Abbate E,de la Barrera SS,Sasiain MC

12-0031 was used in Flow cytometry/Cell sorting to study how the interplay between M. tuberculosis and NK cells/APC triggering IFN-gamma may play a beneficial role in tuberculous pleurisy by helping to maintain a type 1 profile.

Thu Nov 01 00:00:00 EDT 2007

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.

International journal of experimental pathology

DuPré SA,Redelman D,Hunter KW

Published figure using CD3e monoclonal antibody (Product # 12-0031-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2007

Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.

Blood

Takizawa H,Kubo-Akashi C,Nobuhisa I,Kwon SM,Iseki M,Taga T,Takatsu K,Takaki S

12-0031 was used in Flow cytometry/Cell sorting to investigate the potential of Lnk for augmented engraftment of HSCs.

Sat Apr 01 00:00:00 EST 2006

HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.

International journal of cancer

Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH

Thu Jun 01 00:00:00 EDT 2006

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.

The Journal of experimental medicine

Setoguchi R,Hori S,Takahashi T,Sakaguchi S

12-0031 was used in Flow cytometry/Cell sorting to evidence the homeostatic maintenance of Foxp3-expressing CD25+CD4+ regulatory T cells by interleukin (IL)-2, the neutralisation of which, produces a wide spectrum of T cell-mediated autoimmune diseases.

Mon Mar 07 00:00:00 EST 2005

Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Krieg C,Han P,Stone R,Goularte OD,Kaye J

Tue Nov 15 00:00:00 EST 2005

CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.

Investigative ophthalmology & visual science

Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M

Sat Oct 01 00:00:00 EDT 2005

Bioinformatics

Protein Aliases: CD247; CD247 antigen; CD3 antigen, zeta polypeptide; CD3 TCR complex; CD3-zeta/eta; CD3d; CD3e; CD3g; FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex

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Gene Aliases: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; Cd247; CD3; Cd3-eta; Cd3-zeta; Cd3d; Cd3e; CD3epsilon; Cd3g; Cd3h; Cd3z; Cd3zeta; Ctg-3; Ctg3; T3d; T3e; T3g; T3z; Tcrk; Tcrz

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UniProt ID: (Mouse) P24161, (Mouse) P04235, (Mouse) P22646, (Mouse) P11942

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Entrez Gene ID: (Mouse) 12503, (Mouse) 12500, (Mouse) 12501, (Mouse) 12502

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Function(s)

transmembrane signaling receptor activity protein binding identical protein binding protein heterodimerization activity signal transducer activity SH3 domain binding defense/immunity protein immunoglobulin receptor superfamily

Process(es)

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CD3e Monoclonal Antibody (145-2C11), PE, eBioscience™

CD3e Antibody (12-0031-82) in Flow

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12-0031-82

Immunohistochemistry (Frozen) (IHC (F))

Flow Cytometry (Flow)

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