Product References
Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.
Cancer immunology, immunotherapy : CII
Symonds ALJ,Miao T,Busharat Z,Li S,Wang P
45-0031-82 was used in Flow cytometry/Cell sorting to conclude that Egr2 and 3 are important for maintaining anti-tumour responses of exhausted CD8 + TILs.
Mon May 01 00:00:00 EDT 2023
A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells.
Frontiers in immunology
Chang D,Zhang H,Ge J,Xing Q,Guo X,Wang X,Dong C
45-0031-82 was used in Flow cytometry/Cell sorting to identify CNS9 as an essential cis-regulatory element controlling the lineage stability and plasticity of ILC3s through modulating expression levels of RORγt protein.
Tue Mar 28 00:00:00 EDT 2023
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
45-0031-82 was used in Flow Cytometry to investigate the postgastrulation functions of ten-eleven translocation (Tet) enzymes.
Fri Mar 04 00:00:00 EST 2022
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma.
EMBO molecular medicine
Domenger A,Choisy C,Baron L,Mayau V,Perthame E,Deriano L,Arnulf B,Bories JC,Dadaglio G,Demangel C
45-0031-82 was used in Flow Cytometry experiments to establish Sec61 blockers as novel anti-MM agents and reveal the interest of targeting both the translocon and the proteasome in proteostasis-addicted tumors.
Mon Mar 07 00:00:00 EST 2022
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa.
Molecular therapy : the journal of the American Society of Gene Therapy
Vesin B,Lopez J,Noirat A,Authié P,Fert I,Le Chevalier F,Moncoq F,Nemirov K,Blanc C,Planchais C,Mouquet H,Guinet F,Hardy D,Vives FL,Gerke C,Anna F,Bourgine M,Majlessi L,Charneau P
45-0031-82 was used in Flow cytometry/Cell sorting to demonstrate the suitability of the LV::SBeta-2P vaccine candidate as an intranasal booster against COVID-19. LV::SBeta-2P vaccination was also fully protective against Omicron infection of the lungs and central nervous system, in the highly susceptible B6.K18-hACE2IP-THV transgenic mice.
Wed Sep 07 00:00:00 EDT 2022
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Cell stem cell
Zhang D,Gao X,Li H,Borger DK,Wei Q,Yang E,Xu C,Pinho S,Frenette PS
45-0031-82 was used in Flow cytometry/Cell sorting to reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
Thu Feb 03 00:00:00 EST 2022
NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes.
Cell death & disease
Xiao P,Takiishi T,Violato NM,Licata G,Dotta F,Sebastiani G,Marselli L,Singh SP,Sze M,Van Loo G,Dejardin E,Gurzov EN,Cardozo AK
45-0031-82 was used in Flow cytometry/Cell sorting to suggest that NIK activation is dispensable for the development of diabetes.
Thu May 19 00:00:00 EDT 2022
The secreted protein Cowpox Virus 14 contributes to viral virulence and immune evasion by engaging Fc-gamma-receptors.
PLoS pathogens
Iyer RF,Edwards DM,Kolb P,Raué HP,Nelson CA,Epperson ML,Slifka MK,Nolz JC,Hengel H,Fremont DH,Früh K
45-0031-82 was used in flow cytometry experiments to suggest that CPXV14 contributes to virulence and immune evasion by binding to host FcγRs.
Thu Sep 01 00:00:00 EDT 2022
Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis.
Cell & bioscience
Zhao X,Liang W,Wang Y,Yi R,Luo L,Wang W,Sun N,Yu M,Xu W,Sheng Q,Lu L,Pang J,Lv Z,Wang F
45-0031-82 was used in Flow Cytometry to examine the ontogeny of intestinal lamina propria lymphocytes in the early life of mice.
Tue Jan 04 00:00:00 EST 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
45-0031-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
45-0031-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Obesity results in adipose tissue T cell exhaustion.
JCI insight
Porsche CE,Delproposto JB,Geletka L,O'Rourke R,Lumeng CN
45-0031-82 was used in Flow Cytometry to assess adipose tissue T cells activation and inflammatory potential within mouse and human stromal vascular fraction.
Thu Apr 22 00:00:00 EDT 2021
Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis.
Scientific reports
Tran A,Scholtes C,Songane M,Champagne C,Galarneau L,Levasseur MP,Fodil N,Dufour CR,Giguère V,Saleh M
45-0031-82 was used in Immunohistochemistry (Paraffin) to report a protective role of estrogen-related receptor alpha in the intestine.
Fri Jul 23 00:00:00 EDT 2021
Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with GMCSF+IFN α Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model.
Biomedicines
Tham SM,Rahmat JN,Chiong E,Wu Q,Esuvaranathan K,Mahendran R
45-0031-82 was used in Flow cytometry/Cell sorting to evaluate a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains.
Thu Nov 25 00:00:00 EST 2021
Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.
Journal of the American Heart Association
Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS
45-0031-82 was used in Flow Cytometry to demonstrate that Remote Limb Ischemic Postconditioning protects against ischemic brain injury, at least in part by activating and maintaining the Tregs through the nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide hydrate pathway.
Tue Nov 16 00:00:00 EST 2021
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Cell
Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N
45-0031-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.
Thu Jul 23 00:00:00 EDT 2020
The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses.
The Journal of experimental medicine
Chen L,Christian DA,Kochanowsky JA,Phan AT,Clark JT,Wang S,Berry C,Oh J,Chen X,Roos DS,Beiting DP,Koshy AA,Hunter CA
45-0031 was used in Flow cytometry/Cell sorting to investigate the impact of the ability of Toxoplasma gondii injecting the rhoptry kinase ROP16 into host cells on infection.
Mon Mar 02 00:00:00 EST 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
45-0031 was used in Flow cytometry/Cell sorting to study the mechanism by which mesenchymal stem cells can treat steroid resistant acute graft-versus-host disease.
Wed Jan 01 00:00:00 EST 2020
DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.
Journal of cellular and molecular medicine
Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G
45-0031 was used in Flow cytometry/Cell sorting to study DEK-targeting aptamer in EMT-mediated airway remodeling in asthma.
Tue Dec 01 00:00:00 EST 2020
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.
Frontiers in immunology
Briukhovetska D,Ohm B,Mey FT,Aliberti J,Kleingarn M,Huber-Lang M,Karsten CM,Köhl J
45-0031 was used in Flow cytometry/Cell sorting to suggest a model in which the C5a/C5aR1 axis promotes IFN-γ production from NK cells as a mechanism to control acute Toxoplasma gondii infection.
Mon Apr 05 00:00:00 EDT 2021
Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.
Cell reports
Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP
45-0031 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.
Tue Apr 14 00:00:00 EDT 2020
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.
Nature communications
Lang J,Bohn P,Bhat H,Jastrow H,Walkenfort B,Cansiz F,Fink J,Bauer M,Olszewski D,Ramos-Nascimento A,Duhan V,Friedrich SK,Becker KA,Krawczyk A,Edwards MJ,Burchert A,Huber M,Friebus-Kardash J,Göthert JR,Hardt C,Probst HC,Schumacher F,Köhrer K,Kleuser B,Babiychuk EB,Sodeik B,Seibel J,Greber UF,Lang PA,Gulbins E,Lang KS
45-0031-82 was used in Flow Cytometry to show that macrophages take up HSV-1 via endocytosis and transport the virions into multivesicular bodies (MVBs).
Thu Mar 12 00:00:00 EDT 2020
Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.
Immunity
Camara A,Cordeiro OG,Alloush F,Sponsel J,Chypre M,Onder L,Asano K,Tanaka M,Yagita H,Ludewig B,Flacher V,Mueller CG
45-0031 was used in Flow cytometry/Cell sorting to demonstrate that mesenchymal stromal cells created a niche environment with LECs for specialized macrophages to take up residence, complete their differentiation program, and fulfill their immune function.
Tue Jun 18 00:00:00 EDT 2019
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Immunity
Wei SC,Sharma R,Anang NAS,Levine JH,Zhao Y,Mancuso JJ,Setty M,Sharma P,Wang J,Pe'er D,Allison JP
45-0031 was used in Flow cytometry/Cell sorting to implicate negative co-stimulation as a key regulator and determinant of T cell differentiation and suggest that checkpoint blockade might work in part by altering the limits of T cell phenotypes.
Tue Apr 16 00:00:00 EDT 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
45-0031 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
45-0031-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice.
PLoS pathogens
Skalski JH,Limon JJ,Sharma P,Gargus MD,Nguyen C,Tang J,Coelho AL,Hogaboam CM,Crother TR,Underhill DM
45-0031 was used in Flow cytometry/Cell sorting to investigate the effects of the population expansion of commensal fungus Wallemia mellicola without overgrowth of the total fungal community.
Sat Sep 01 00:00:00 EDT 2018
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
45-0031 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.
mBio
Gralinski LE,Sheahan TP,Morrison TE,Menachery VD,Jensen K,Leist SR,Whitmore A,Heise MT,Baric RS
45-0031 was used in Flow cytometry/Cell sorting to study complement signalling as regulating a proinflammatory response to SARS-CoV infection.
Tue Oct 09 00:00:00 EDT 2018
Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing.
Nature communications
Sheng C,Yao C,Wang Z,Chen H,Zhao Y,Xu D,Huang H,Huang W,Chen S
45-0031 was used in Flow cytometry/Cell sorting to identify cyclophilin J as a negative feedback regulator of the NF-ΚB signalling pathway.
Mon Oct 22 00:00:00 EDT 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
45-0031 was used in Flow cytometry/Cell sorting to assess the efficacy of a personalised cancer vaccine for eliciting postsurgical tumour specific-immunity.
Wed Apr 18 00:00:00 EDT 2018
Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.
Nature communications
Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS
45-0031 was used in Flow cytometry/Cell sorting to characterise the expression signature that distinguishes arterial endothelial cells from sinusoidal endothelial cells.
Fri Jun 22 00:00:00 EDT 2018
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
Immunity, inflammation and disease
Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P
45-0031 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.
Fri Jun 01 00:00:00 EDT 2018
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.
Immunity
Wu J,Zhang H,Shi X,Xiao X,Fan Y,Minze LJ,Wang J,Ghobrial RM,Xia J,Sciammas R,Li XC,Chen W
45-0031-82 was used in Flow Cytometry to demonstrate that interferon regulatory factor 4 was a key transcriptional determinant controlling T cell responses during transplantation.
Tue Dec 19 00:00:00 EST 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
45-0031 was used in Flow cytometry/Cell sorting to demonstrate that the effects of cytokines regulating haematopoietic stem cell functions are dependent on the producing cell sources.
Wed Mar 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
45-0031 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.
Mon Jun 05 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
45-0031 was used in Flow cytometry/Cell sorting to genetically investigate the role of the interleukin-1 receptor 1 pathway in breast cancer tumourigenesis and metastasis using a mouse model.
Tue Jan 12 00:00:00 EST 2021
Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.
Journal of hepatology
Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ
45-0031 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.
Fri Jan 01 00:00:00 EST 2016
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Nature cell biology
Welte T,Kim IS,Tian L,Gao X,Wang H,Li J,Holdman XB,Herschkowitz JI,Pond A,Xie G,Kurley S,Nguyen T,Liao L,Dobrolecki LE,Pang L,Mo Q,Edwards DP,Huang S,Xin L,Xu J,Li Y,Lewis MT,Wang T,Westbrook TF,Rosen JM,Zhang XH
45003182 was used in flow cytometry to describe the role of mTOR signalling in recruiting pro-tumorigenic myeloid-derived suppressor cells.
Wed Jun 01 00:00:00 EDT 2016
FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal.
The Journal of clinical investigation
Haemmerle M,Bottsford-Miller J,Pradeep S,Taylor ML,Choi HJ,Hansen JM,Dalton HJ,Stone RL,Cho MS,Nick AM,Nagaraja AS,Gutschner T,Gharpure KM,Mangala LS,Rupaimoole R,Han HD,Zand B,Armaiz-Pena GN,Wu SY,Pecot CV,Burns AR,Lopez-Berestein G,Afshar-Kharghan V,Sood AK
45-0031 was used in Flow cytometry/Cell sorting to identify focal adhesion kinase, FAK, as a target for ovarian cancer management in situations in which antiangiogenic agents are withdrawn.
Mon May 02 00:00:00 EDT 2016
A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.
Mucosal immunology
Dagenais M,Dupaul-Chicoine J,Champagne C,Skeldon A,Morizot A,Saleh M
45-0031 was used in Immunofluorescence-paraffin to investigate the function of cellular inhibitors of apoptosis proteins in intestinal cancer and mechanisms in disease pathogenesis.
Fri Jan 01 00:00:00 EST 2016
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Journal of immunology (Baltimore, Md. : 1950)
Skeldon AM,Morizot A,Douglas T,Santoro N,Kursawe R,Kozlitina J,Caprio S,Mehal WZ,Saleh M
45-0031 was used in Flow cytometry/Cell sorting to investigate a role for caspase-11 and caspase-12 in obesity and insulin resistance.
Fri Jan 01 00:00:00 EST 2016
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
International journal of cancer
Geng H,Zhang GM,Xiao H,Yuan Y,Li D,Zhang H,Qiu H,He YF,Feng ZH
Thu Jun 01 00:00:00 EDT 2006
Functional analysis of B and T lymphocyte attenuator engagement on CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Krieg C,Han P,Stone R,Goularte OD,Kaye J
Tue Nov 15 00:00:00 EST 2005
CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response.
Investigative ophthalmology & visual science
Takeuchi A,Usui Y,Takeuchi M,Hattori T,Kezuka T,Suzuki J,Okunuki Y,Iwasaki T,Haino M,Matsushima K,Usui M
Sat Oct 01 00:00:00 EDT 2005
